Last updated: 2022-08-20

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File Version Author Date Message
Rmd b427d90 abalan2 2022-08-19 added table S20
html b427d90 abalan2 2022-08-19 added table S20
Cancer type RAS Non-RAS Non-RAS alteration type RAS(n) non-RAS(n) Group Mean 2.5% 97.5% n_eff Rhat 00 10 01 11 Driver -log10(p)
colorectal cancer RAS_12-61 SPEN Any mutation 375 11 TMB quintile 4 -0.65 -1.89 0.52 1567.85 1.00 409 371 7 4 FALSE 0.53
colorectal cancer RAS_12-61 SPEN Any mutation 340 31 TMB quintile 5 -0.42 -1.15 0.30 1577.73 1.00 273 326 17 14 FALSE 0.62
colorectal cancer RAS_12-61 SPEN Any mutation 39 107 TMB quintile 6 -0.83 -1.53 -0.12 1256.67 1.00 50 22 90 17 FALSE 1.73
melanoma RAS_12-61 SPEN Any mutation 163 55 TMB quintile 5 0.13 -0.44 0.72 1551.42 1.00 210 139 31 24 FALSE 0.18
melanoma RAS_12-61 SPEN Any mutation 10 56 TMB quintile 6 -0.06 -1.31 1.22 1612.58 1.00 34 4 50 6 FALSE 0.03
non-small cell lung cancer RAS_12-61 SPEN Any mutation 267 15 TMB quintile 4 -1.27 -2.66 -0.16 1478.70 1.00 482 265 13 2 FALSE 1.37
non-small cell lung cancer RAS_12-61 SPEN Any mutation 476 87 TMB quintile 5 -0.79 -1.32 -0.28 1489.92 1.00 710 456 67 20 FALSE 2.49
uterine cancer RAS_12-61 SPEN Any mutation 71 37 TMB quintile 5 0.51 -0.21 1.24 1484.69 1.00 170 57 23 14 FALSE 0.77
uterine cancer RAS_12-61 SPEN Any mutation 15 77 TMB quintile 6 -0.56 -1.64 0.56 1330.89 1.00 23 6 68 9 FALSE 0.49
colorectal cancer RAS_12-61 SPEN Any mutation 754 149 TMB overall -0.60 -2.58 1.49 1423.08 1.00 732 719 114 35 FALSE 0.25
melanoma RAS_12-61 SPEN Any mutation 173 111 TMB overall 0.03 -2.46 2.44 1518.03 1.00 244 143 81 30 FALSE 0.01
non-small cell lung cancer RAS_12-61 SPEN Any mutation 743 102 TMB overall -1.00 -2.63 0.65 1421.98 1.00 1192 721 80 22 FALSE 0.66
uterine cancer RAS_12-61 SPEN Any mutation 86 114 TMB overall -0.02 -2.80 2.64 1611.37 1.00 193 63 91 23 FALSE 0.00
colorectal cancer RAS_12-61 KMT2C Any mutation 367 12 TMB quintile 4 -0.42 -1.55 0.63 1578.07 1.00 399 362 7 5 FALSE 0.34
colorectal cancer RAS_12-61 KMT2C Any mutation 320 61 TMB quintile 5 -0.58 -1.12 -0.04 1432.68 1.00 240 295 36 25 FALSE 1.43
colorectal cancer RAS_12-61 KMT2C Any mutation 47 116 TMB quintile 6 -0.34 -1.01 0.33 1315.00 1.00 51 21 90 26 FALSE 0.52
melanoma RAS_12-61 KMT2C Any mutation 157 85 TMB quintile 5 -0.30 -0.81 0.22 1247.58 1.00 176 127 55 30 FALSE 0.60
melanoma RAS_12-61 KMT2C Any mutation 10 54 TMB quintile 6 -0.38 -1.61 0.85 1553.59 1.00 24 4 48 6 FALSE 0.26
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 159 13 TMB quintile 3 -1.04 -2.46 0.10 1460.96 1.00 451 158 12 1 FALSE 0.92
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 267 36 TMB quintile 4 -0.31 -1.04 0.40 1466.55 1.00 469 256 25 11 FALSE 0.41
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 476 155 TMB quintile 5 -0.35 -0.70 0.01 1547.17 1.00 648 427 106 49 FALSE 1.23
uterine cancer RAS_12-61 KMT2C Any mutation 68 42 TMB quintile 5 -0.66 -1.58 0.10 1397.71 1.00 147 60 34 8 FALSE 0.91
uterine cancer RAS_12-61 KMT2C Any mutation 13 91 TMB quintile 6 -1.77 -3.01 -0.58 1448.30 1.00 15 7 85 6 FALSE 2.36
colorectal cancer RAS_12-61 KMT2C Any mutation 734 189 TMB overall -0.45 -2.28 1.48 1355.53 1.00 690 678 133 56 FALSE 0.20
melanoma RAS_12-61 KMT2C Any mutation 167 139 TMB overall -0.30 -2.32 2.04 1504.93 1.00 200 131 103 36 FALSE 0.11
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 902 204 TMB overall -0.58 -1.73 0.53 1443.05 1.00 1568 841 143 61 FALSE 0.51
uterine cancer RAS_12-61 KMT2C Any mutation 81 133 TMB overall -1.08 -3.61 1.77 1426.94 1.00 162 67 119 14 FALSE 0.38
cancer of unknown primary RAS_12-61 TP53 Any mutation 30 39 TMB quintile 2 -0.04 -0.81 0.76 1262.86 1.00 60 18 27 12 TRUE 0.03
cancer of unknown primary RAS_12-61 TP53 Any mutation 40 74 TMB quintile 3 -0.32 -0.94 0.35 1412.72 1.00 50 21 55 19 TRUE 0.49
cancer of unknown primary RAS_12-61 TP53 Any mutation 40 87 TMB quintile 4 -0.83 -1.50 -0.17 1443.10 1.00 37 23 70 17 TRUE 1.87
cancer of unknown primary RAS_12-61 TP53 Any mutation 49 153 TMB quintile 5 -0.84 -1.45 -0.22 1331.44 1.00 35 21 125 28 TRUE 2.11
colorectal cancer RAS_12-61 TP53 Any mutation 28 104 TMB quintile 2 -1.31 -2.06 -0.53 1517.90 1.00 21 13 89 15 TRUE 3.11
colorectal cancer RAS_12-61 TP53 Any mutation 193 411 TMB quintile 3 -1.50 -2.02 -1.03 1540.23 1.00 24 61 279 132 TRUE 9.10
colorectal cancer RAS_12-61 TP53 Any mutation 387 655 TMB quintile 4 -1.22 -1.57 -0.87 1395.91 1.00 51 124 392 263 TRUE 11.22
colorectal cancer RAS_12-61 TP53 Any mutation 363 423 TMB quintile 5 -0.53 -0.86 -0.24 1449.90 1.00 95 154 214 209 TRUE 3.13
colorectal cancer RAS_12-61 TP53 Any mutation 45 78 TMB quintile 6 -0.47 -1.08 0.20 1412.72 1.00 66 26 59 19 TRUE 0.81
melanoma RAS_12-61 TP53 Any mutation 17 14 TMB quintile 3 -1.35 -3.77 0.26 1496.19 1.00 81 17 14 0 TRUE 0.73
melanoma RAS_12-61 TP53 Any mutation 22 16 TMB quintile 4 0.31 -0.87 1.40 1330.98 1.00 72 17 11 5 TRUE 0.23
melanoma RAS_12-61 TP53 Any mutation 165 119 TMB quintile 5 -0.28 -0.72 0.15 1586.89 1.00 167 123 77 42 TRUE 0.68
melanoma RAS_12-61 TP53 Any mutation 11 52 TMB quintile 6 0.15 -0.94 1.28 1388.73 1.00 26 3 44 8 TRUE 0.10
non-small cell lung cancer RAS_12-61 TP53 Any mutation 83 180 TMB quintile 2 -1.13 -1.68 -0.58 1537.65 1.00 199 64 161 19 TRUE 4.10
non-small cell lung cancer RAS_12-61 TP53 Any mutation 159 324 TMB quintile 3 -1.56 -1.95 -1.19 1329.64 1.00 194 121 286 38 TRUE 14.52
non-small cell lung cancer RAS_12-61 TP53 Any mutation 270 450 TMB quintile 4 -1.41 -1.72 -1.11 1475.00 1.00 162 176 356 94 TRUE 18.70
non-small cell lung cancer RAS_12-61 TP53 Any mutation 491 996 TMB quintile 5 -1.74 -2.01 -1.47 1536.96 1.00 105 227 732 264 TRUE 34.74
pancreatic cancer RAS_12-61 TP53 Any mutation 277 216 TMB quintile 2 2.65 2.07 3.41 1382.04 1.00 62 68 7 209 TRUE 14.81
pancreatic cancer RAS_12-61 TP53 Any mutation 459 392 TMB quintile 3 2.51 2.03 3.02 1245.46 1.00 49 85 18 374 TRUE 34.74
pancreatic cancer RAS_12-61 TP53 Any mutation 243 206 TMB quintile 4 2.15 1.52 2.71 1369.65 1.00 25 53 16 190 TRUE 11.44
pancreatic cancer RAS_12-61 TP53 Any mutation 38 34 TMB quintile 5 1.98 1.16 2.71 1328.23 1.00 11 11 7 27 TRUE 6.17
uterine cancer RAS_12-61 TP53 Any mutation 14 77 TMB quintile 2 -1.18 -2.03 -0.38 1407.15 1.00 59 10 73 4 TRUE 2.25
uterine cancer RAS_12-61 TP53 Any mutation 27 167 TMB quintile 3 -1.16 -1.86 -0.46 1590.27 1.00 68 16 156 11 TRUE 2.98
uterine cancer RAS_12-61 TP53 Any mutation 48 132 TMB quintile 4 -1.37 -2.02 -0.79 1485.36 1.00 76 36 120 12 TRUE 4.83
uterine cancer RAS_12-61 TP53 Any mutation 73 68 TMB quintile 5 -0.68 -1.31 -0.08 1656.66 1.00 144 59 54 14 TRUE 1.52
uterine cancer RAS_12-61 TP53 Any mutation 11 39 TMB quintile 6 -0.96 -1.86 -0.05 1699.54 1.00 31 7 35 4 TRUE 1.42
cancer of unknown primary RAS_12-61 TP53 Any mutation 163 378 TMB overall -0.61 -1.43 0.16 1452.88 1.00 183 85 300 78 TRUE 0.89
colorectal cancer RAS_12-61 TP53 Any mutation 1016 1671 TMB overall -1.00 -1.83 -0.14 1392.35 1.00 257 378 1033 638 TRUE 1.71
melanoma RAS_12-61 TP53 Any mutation 215 201 TMB overall -0.28 -1.67 0.91 1423.09 1.00 346 160 146 55 TRUE 0.17
non-small cell lung cancer RAS_12-61 TP53 Any mutation 1003 1950 TMB overall -1.45 -2.36 -0.58 1485.47 1.00 660 588 1535 415 TRUE 3.01
pancreatic cancer RAS_12-61 TP53 Any mutation 1017 848 TMB overall 2.32 1.70 2.92 1134.10 1.00 147 217 48 800 TRUE 13.28
uterine cancer RAS_12-61 TP53 Any mutation 173 483 TMB overall -1.05 -1.72 -0.37 1420.44 1.00 378 128 438 45 TRUE 2.75
colorectal cancer RAS_12-61 ATRX Any mutation 375 19 TMB quintile 4 -0.56 -1.44 0.29 1368.82 1.00 404 368 12 7 TRUE 0.68
colorectal cancer RAS_12-61 ATRX Any mutation 338 35 TMB quintile 5 -0.60 -1.23 0.07 1664.89 1.00 269 324 21 14 TRUE 1.13
colorectal cancer RAS_12-61 ATRX Any mutation 42 59 TMB quintile 6 -0.24 -0.91 0.50 1415.35 1.00 73 28 45 14 TRUE 0.28
melanoma RAS_12-61 ATRX Any mutation 162 58 TMB quintile 5 -0.30 -0.89 0.28 1323.07 1.00 209 142 38 20 TRUE 0.52
melanoma RAS_12-61 ATRX Any mutation 8 30 TMB quintile 6 -3.02 -8.22 -0.40 1433.25 1.00 46 8 30 0 TRUE 0.86
non-small cell lung cancer RAS_12-61 ATRX Any mutation 267 32 TMB quintile 4 0.04 -0.65 0.69 1480.76 1.00 476 255 20 12 TRUE 0.04
non-small cell lung cancer RAS_12-61 ATRX Any mutation 481 160 TMB quintile 5 0.12 -0.22 0.45 1591.41 1.00 673 416 95 65 TRUE 0.31
uterine cancer RAS_12-61 ATRX Any mutation 14 11 TMB quintile 2 -2.30 -6.24 0.14 1374.48 1.00 120 14 11 0 TRUE 0.83
uterine cancer RAS_12-61 ATRX Any mutation 26 14 TMB quintile 3 -2.44 -5.76 -0.11 1437.18 1.00 201 26 14 0 TRUE 0.96
uterine cancer RAS_12-61 ATRX Any mutation 70 19 TMB quintile 5 -0.60 -1.88 0.49 1482.72 1.00 179 66 15 4 TRUE 0.50
uterine cancer RAS_12-61 ATRX Any mutation 12 112 TMB quintile 6 -1.18 -2.33 -0.03 1470.37 1.00 23 5 105 7 TRUE 1.33
colorectal cancer RAS_12-61 ATRX Any mutation 755 113 TMB overall -0.45 -1.85 1.04 1403.82 1.00 746 720 78 35 TRUE 0.26
melanoma RAS_12-61 ATRX Any mutation 170 88 TMB overall -1.42 -4.96 1.34 1547.82 1.00 255 150 68 20 TRUE 0.45
non-small cell lung cancer RAS_12-61 ATRX Any mutation 748 192 TMB overall 0.09 -1.20 1.38 1551.49 1.00 1149 671 115 77 TRUE 0.05
uterine cancer RAS_12-61 ATRX Any mutation 122 156 TMB overall -1.57 -3.75 0.30 1442.51 1.00 523 111 145 11 TRUE 0.87
colorectal cancer RAS_12-61 ATR Any mutation 339 35 TMB quintile 5 -0.54 -1.22 0.15 1466.63 1.00 268 324 20 15 FALSE 0.94
colorectal cancer RAS_12-61 ATR Any mutation 42 65 TMB quintile 6 -0.87 -1.70 -0.11 1456.84 1.00 74 32 55 10 FALSE 1.49
non-small cell lung cancer RAS_12-61 ATR Any mutation 159 12 TMB quintile 3 -0.50 -1.67 0.56 1438.94 1.00 457 157 10 2 FALSE 0.42
non-small cell lung cancer RAS_12-61 ATR Any mutation 268 15 TMB quintile 4 -0.07 -0.94 0.82 1341.06 1.00 487 262 9 6 FALSE 0.05
non-small cell lung cancer RAS_12-61 ATR Any mutation 475 93 TMB quintile 5 -0.22 -0.68 0.20 1297.41 1.00 688 444 62 31 FALSE 0.51
colorectal cancer RAS_12-61 ATR Any mutation 381 100 TMB overall -0.69 -3.01 1.77 1405.21 1.00 342 356 75 25 FALSE 0.25
non-small cell lung cancer RAS_12-61 ATR Any mutation 902 120 TMB overall -0.25 -1.26 0.76 1618.20 1.00 1632 863 81 39 FALSE 0.21
non-small cell lung cancer RAS_12-61 PDGFRA Any mutation 267 16 TMB quintile 4 -0.07 -0.99 0.85 1474.49 1.00 485 261 10 6 TRUE 0.05
non-small cell lung cancer RAS_12-61 PDGFRA Any mutation 476 115 TMB quintile 5 -0.29 -0.70 0.13 1351.43 1.00 676 439 78 37 TRUE 0.75
non-small cell lung cancer RAS_12-61 PDGFRA Any mutation 743 131 TMB overall -0.21 -1.96 1.58 1582.11 1.00 1161 700 88 43 TRUE 0.09
colorectal cancer RAS_12-61 FBXW7 Any mutation 192 22 TMB quintile 3 -0.50 -1.35 0.29 1433.67 1.00 280 186 16 6 TRUE 0.64
colorectal cancer RAS_12-61 FBXW7 Any mutation 381 85 TMB quintile 4 0.22 -0.21 0.65 1268.58 1.00 381 336 40 45 TRUE 0.49
colorectal cancer RAS_12-61 FBXW7 Any mutation 357 160 TMB quintile 5 0.39 0.04 0.74 1357.62 1.00 232 258 61 99 TRUE 1.54
colorectal cancer RAS_12-61 FBXW7 Any mutation 38 65 TMB quintile 6 0.42 -0.23 1.09 1445.67 1.00 66 18 45 20 TRUE 0.64
uterine cancer RAS_12-61 FBXW7 Any mutation 26 30 TMB quintile 3 -0.36 -1.56 0.71 1494.89 1.00 188 24 28 2 TRUE 0.27
uterine cancer RAS_12-61 FBXW7 Any mutation 48 29 TMB quintile 4 0.17 -0.71 0.96 1537.09 1.00 159 41 22 7 TRUE 0.16
uterine cancer RAS_12-61 FBXW7 Any mutation 70 30 TMB quintile 5 0.41 -0.35 1.16 1207.62 1.00 173 59 19 11 TRUE 0.54
uterine cancer RAS_12-61 FBXW7 Any mutation 14 47 TMB quintile 6 0.48 -0.52 1.51 1416.17 1.00 25 4 37 10 TRUE 0.45
colorectal cancer RAS_12-61 FBXW7 Any mutation 968 332 TMB overall 0.15 -0.86 1.08 1434.16 1.00 959 798 162 170 TRUE 0.12
uterine cancer RAS_12-61 FBXW7 Any mutation 158 136 TMB overall 0.17 -0.92 1.28 961.07 1.00 545 128 106 30 TRUE 0.12
uterine cancer RAS_12-61 NSD1 Any mutation 73 46 TMB quintile 5 -0.20 -0.93 0.49 1252.32 1.00 165 62 35 11 FALSE 0.24
uterine cancer RAS_12-61 NSD1 Any mutation 17 69 TMB quintile 6 0.50 -0.68 1.89 1432.73 1.00 21 3 55 14 FALSE 0.37
uterine cancer RAS_12-61 NSD1 Any mutation 90 115 TMB overall 0.17 -2.24 2.79 1333.56 1.00 186 65 90 25 FALSE 0.05
colorectal cancer RAS_12-61 FLT4 Any mutation 375 20 TMB quintile 4 -0.02 -0.85 0.83 1527.40 1.00 406 365 10 10 TRUE 0.02
colorectal cancer RAS_12-61 FLT4 Any mutation 339 40 TMB quintile 5 -0.50 -1.10 0.13 1569.68 1.00 268 322 23 17 TRUE 0.92
colorectal cancer RAS_12-61 FLT4 Any mutation 40 72 TMB quintile 6 -0.33 -1.08 0.43 1514.89 1.00 59 24 56 16 TRUE 0.41
non-small cell lung cancer RAS_12-61 FLT4 Any mutation 267 14 TMB quintile 4 0.32 -0.61 1.38 1310.97 1.00 488 260 7 7 TRUE 0.28
non-small cell lung cancer RAS_12-61 FLT4 Any mutation 476 74 TMB quintile 5 -0.19 -0.68 0.32 1414.87 1.00 702 451 49 25 TRUE 0.33
colorectal cancer RAS_12-61 FLT4 Any mutation 754 132 TMB overall -0.27 -1.86 1.49 1401.88 1.00 733 711 89 43 TRUE 0.12
non-small cell lung cancer RAS_12-61 FLT4 Any mutation 743 88 TMB overall 0.09 -1.47 1.86 1426.44 1.00 1190 711 56 32 TRUE 0.04
colorectal cancer RAS_12-61 PTPRD Any mutation 338 29 TMB quintile 5 -0.87 -1.65 -0.14 1551.42 1.00 271 328 19 10 FALSE 1.57
colorectal cancer RAS_12-61 PTPRD Any mutation 38 61 TMB quintile 6 -0.56 -1.34 0.21 1367.07 1.00 72 27 50 11 FALSE 0.81
melanoma RAS_12-61 PTPRD Any mutation 169 147 TMB quintile 5 -0.32 -0.74 0.12 1442.35 1.00 164 118 96 51 FALSE 0.86
melanoma RAS_12-61 PTPRD Any mutation 13 115 TMB quintile 6 -0.15 -1.40 1.43 1617.08 1.00 19 2 104 11 FALSE 0.08
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 159 16 TMB quintile 3 0.15 -0.94 1.17 1223.60 1.00 457 154 11 5 FALSE 0.11
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 268 53 TMB quintile 4 0.58 0.02 1.15 1490.80 1.00 468 242 27 26 FALSE 1.40
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 495 298 TMB quintile 5 -0.01 -0.28 0.24 1489.22 1.00 596 380 183 115 FALSE 0.02
colorectal cancer RAS_12-61 PTPRD Any mutation 376 90 TMB overall -0.67 -3.00 1.65 1538.76 1.00 343 355 69 21 FALSE 0.25
melanoma RAS_12-61 PTPRD Any mutation 182 262 TMB overall -0.20 -2.57 2.61 1462.12 1.00 183 120 200 62 FALSE 0.06
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 923 384 TMB overall 0.18 -1.49 1.84 1346.14 1.00 1528 776 237 147 FALSE 0.08
melanoma RAS_12-61 PIK3C2G Any mutation 159 99 TMB quintile 5 -0.03 -0.50 0.42 1532.12 1.00 174 119 59 40 FALSE 0.05
melanoma RAS_12-61 PIK3C2G Any mutation 14 85 TMB quintile 6 -0.19 -1.38 1.15 1447.50 1.00 17 3 74 11 FALSE 0.11
non-small cell lung cancer RAS_12-61 PIK3C2G Any mutation 267 12 TMB quintile 4 -0.28 -1.42 0.78 1245.60 1.00 484 263 8 4 FALSE 0.21
non-small cell lung cancer RAS_12-61 PIK3C2G Any mutation 474 103 TMB quintile 5 -0.40 -0.85 0.01 1291.06 1.00 679 443 72 31 FALSE 1.16
melanoma RAS_12-61 PIK3C2G Any mutation 173 184 TMB overall -0.07 -2.60 2.39 1615.92 1.00 191 122 133 51 FALSE 0.02
non-small cell lung cancer RAS_12-61 PIK3C2G Any mutation 741 115 TMB overall -0.30 -2.04 1.63 1342.25 1.00 1163 706 80 35 FALSE 0.13
colorectal cancer RAS_12-61 CREBBP Any mutation 375 17 TMB quintile 4 -0.88 -2.01 0.08 1370.09 1.00 404 370 12 5 TRUE 0.97
colorectal cancer RAS_12-61 CREBBP Any mutation 341 49 TMB quintile 5 -0.24 -0.80 0.34 1593.53 1.00 267 317 25 24 TRUE 0.38
colorectal cancer RAS_12-61 CREBBP Any mutation 48 116 TMB quintile 6 -0.57 -1.18 0.09 1514.97 1.00 42 22 90 26 TRUE 1.10
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 159 11 TMB quintile 3 -0.18 -1.30 0.93 1414.85 1.00 459 156 8 3 TRUE 0.12
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 267 12 TMB quintile 4 -0.26 -1.28 0.79 1262.95 1.00 487 263 8 4 TRUE 0.20
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 474 106 TMB quintile 5 -0.32 -0.75 0.09 1556.61 1.00 685 441 73 33 TRUE 0.88
colorectal cancer RAS_12-61 CREBBP Any mutation 764 182 TMB overall -0.50 -2.33 1.33 1388.26 1.00 713 709 127 55 TRUE 0.24
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 900 129 TMB overall -0.24 -1.38 0.92 1265.32 1.00 1631 860 89 40 TRUE 0.17
colorectal cancer RAS_12-61 AXIN2 Any mutation 375 20 TMB quintile 4 0.52 -0.33 1.46 1016.30 1.00 409 362 7 13 TRUE 0.61
colorectal cancer RAS_12-61 AXIN2 Any mutation 338 27 TMB quintile 5 -0.70 -1.51 0.08 1452.14 1.00 272 328 17 10 TRUE 1.08
colorectal cancer RAS_12-61 AXIN2 Any mutation 38 63 TMB quintile 6 -0.45 -1.25 0.31 1493.35 1.00 69 26 51 12 TRUE 0.59
colorectal cancer RAS_12-61 AXIN2 Any mutation 751 110 TMB overall -0.22 -1.96 1.50 1374.20 1.00 750 716 75 35 TRUE 0.09
non-small cell lung cancer RAS_12-61 DOT1L Any mutation 267 24 TMB quintile 4 -0.47 -1.27 0.23 1491.91 1.00 479 261 18 6 FALSE 0.67
non-small cell lung cancer RAS_12-61 DOT1L Any mutation 475 75 TMB quintile 5 -0.27 -0.72 0.20 1521.93 1.00 699 450 50 25 FALSE 0.57
non-small cell lung cancer RAS_12-61 DOT1L Any mutation 742 99 TMB overall -0.36 -1.34 0.66 1460.50 1.00 1178 711 68 31 FALSE 0.33
colorectal cancer RAS_12-61 PTPRS Any mutation 188 17 TMB quintile 3 -0.78 -1.92 0.24 1461.57 1.00 281 184 13 4 FALSE 0.82
colorectal cancer RAS_12-61 PTPRS Any mutation 367 34 TMB quintile 4 0.01 -0.67 0.70 1440.87 1.00 389 350 17 17 FALSE 0.01
colorectal cancer RAS_12-61 PTPRS Any mutation 324 74 TMB quintile 5 -0.31 -0.78 0.16 1540.22 1.00 237 289 39 35 FALSE 0.66
colorectal cancer RAS_12-61 PTPRS Any mutation 44 128 TMB quintile 6 -0.25 -0.91 0.47 1408.75 1.00 35 14 98 30 FALSE 0.32
colorectal cancer RAS_12-61 PTPRS Any mutation 923 253 TMB overall -0.35 -1.81 1.08 1567.64 1.00 942 837 167 86 FALSE 0.20
colorectal cancer RAS_12-61 SMARCA4 Any mutation 375 16 TMB quintile 4 -0.79 -1.86 0.24 1450.08 1.00 405 370 11 5 FALSE 0.86
colorectal cancer RAS_12-61 SMARCA4 Any mutation 339 47 TMB quintile 5 -0.60 -1.19 0.00 1400.64 1.00 263 320 28 19 FALSE 1.31
colorectal cancer RAS_12-61 SMARCA4 Any mutation 43 100 TMB quintile 6 -0.22 -0.88 0.46 1453.00 1.00 55 20 77 23 FALSE 0.30
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 160 35 TMB quintile 3 0.56 -0.09 1.22 1404.06 1.00 450 145 20 15 FALSE 1.02
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 268 67 TMB quintile 4 0.05 -0.41 0.52 1441.75 1.00 455 244 43 24 FALSE 0.08
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 479 194 TMB quintile 5 -0.12 -0.43 0.18 1478.57 1.00 630 410 125 69 FALSE 0.33
uterine cancer RAS_12-61 SMARCA4 Any mutation 72 39 TMB quintile 5 -0.59 -1.50 0.18 1528.81 1.00 168 65 32 7 FALSE 0.76
uterine cancer RAS_12-61 SMARCA4 Any mutation 15 52 TMB quintile 6 0.13 -0.86 1.14 1521.79 1.00 26 5 42 10 FALSE 0.09
colorectal cancer RAS_12-61 SMARCA4 Any mutation 757 163 TMB overall -0.49 -2.22 1.29 1419.88 1.00 723 710 116 47 FALSE 0.24
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 907 296 TMB overall 0.16 -0.70 0.98 1460.15 1.00 1535 799 188 108 FALSE 0.15
uterine cancer RAS_12-61 SMARCA4 Any mutation 87 91 TMB overall -0.26 -2.42 1.94 1743.70 1.00 194 70 74 17 FALSE 0.09
colorectal cancer RAS_12-61 PTPRT Any mutation 192 18 TMB quintile 3 0.59 -0.27 1.51 1397.74 1.00 288 181 7 11 FALSE 0.71
colorectal cancer RAS_12-61 PTPRT Any mutation 375 39 TMB quintile 4 -0.94 -1.65 -0.23 1620.29 1.00 387 365 29 10 FALSE 2.11
colorectal cancer RAS_12-61 PTPRT Any mutation 340 59 TMB quintile 5 -0.41 -0.93 0.12 1482.37 1.00 256 314 33 26 FALSE 0.90
colorectal cancer RAS_12-61 PTPRT Any mutation 43 66 TMB quintile 6 0.48 -0.20 1.20 1545.16 1.00 72 21 44 22 FALSE 0.78
melanoma RAS_12-61 PTPRT Any mutation 176 200 TMB quintile 5 0.10 -0.28 0.50 1581.91 1.00 153 95 119 81 FALSE 0.22
melanoma RAS_12-61 PTPRT Any mutation 22 153 TMB quintile 6 1.82 -0.48 5.76 1413.67 1.00 13 0 131 22 FALSE 0.50
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 159 17 TMB quintile 3 -0.24 -1.48 0.77 1376.22 1.00 454 155 13 4 FALSE 0.18
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 268 38 TMB quintile 4 0.02 -0.65 0.68 1473.24 1.00 471 254 24 14 FALSE 0.03
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 483 272 TMB quintile 5 -0.48 -0.75 -0.20 1381.19 1.00 600 403 192 80 FALSE 3.00
colorectal cancer RAS_12-61 PTPRT Any mutation 950 182 TMB overall -0.08 -1.20 1.08 1506.57 1.00 1003 881 113 69 FALSE 0.05
melanoma RAS_12-61 PTPRT Any mutation 198 353 TMB overall 0.88 -2.38 4.72 1475.90 1.00 166 95 250 103 FALSE 0.21
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 911 348 TMB overall -0.29 -2.08 1.61 1272.75 1.00 1530 812 249 99 FALSE 0.12
non-small cell lung cancer RAS_12-61 HGF Any mutation 267 27 TMB quintile 4 -0.32 -1.22 0.54 1588.66 1.00 477 259 19 8 FALSE 0.33
non-small cell lung cancer RAS_12-61 HGF Any mutation 476 138 TMB quintile 5 0.11 -0.27 0.45 1496.85 1.00 673 419 81 57 FALSE 0.25
non-small cell lung cancer RAS_12-61 HGF Any mutation 744 180 TMB overall -0.09 -2.34 2.18 1563.69 1.00 1157 678 114 66 FALSE 0.03
colorectal cancer RAS_12-61 PIK3CA Any mutation 194 51 TMB quintile 3 0.92 0.37 1.50 1461.15 1.00 277 162 19 32 TRUE 2.80
colorectal cancer RAS_12-61 PIK3CA Any mutation 378 146 TMB quintile 4 0.46 0.09 0.84 1625.24 1.00 356 295 63 83 TRUE 1.91
colorectal cancer RAS_12-61 PIK3CA Any mutation 352 209 TMB quintile 5 0.41 0.09 0.75 1507.04 1.00 214 225 82 127 TRUE 1.76
colorectal cancer RAS_12-61 PIK3CA Any mutation 44 95 TMB quintile 6 0.40 -0.22 1.04 1497.03 1.00 56 16 67 28 TRUE 0.66
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 83 18 TMB quintile 2 -0.77 -1.78 0.04 1504.36 1.00 341 82 17 1 TRUE 0.97
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 159 34 TMB quintile 3 -0.23 -0.91 0.44 1542.72 1.00 442 150 25 9 TRUE 0.31
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 268 56 TMB quintile 4 -0.66 -1.26 -0.12 1516.03 1.00 451 256 44 12 TRUE 1.64
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 475 123 TMB quintile 5 -0.41 -0.81 -0.04 1477.57 1.00 671 438 86 37 TRUE 1.46
uterine cancer RAS_12-61 PIK3CA Any mutation 14 33 TMB quintile 2 -0.04 -1.20 0.99 1187.21 1.00 102 11 30 3 TRUE 0.02
uterine cancer RAS_12-61 PIK3CA Any mutation 26 103 TMB quintile 3 0.18 -0.55 0.92 1520.70 1.00 134 14 91 12 TRUE 0.19
uterine cancer RAS_12-61 PIK3CA Any mutation 54 121 TMB quintile 4 0.66 0.09 1.24 1583.07 1.00 105 20 87 34 TRUE 1.63
uterine cancer RAS_12-61 PIK3CA Any mutation 86 196 TMB quintile 5 0.15 -0.34 0.61 1636.64 1.00 89 32 142 54 TRUE 0.26
uterine cancer RAS_12-61 PIK3CA Any mutation 18 95 TMB quintile 6 0.33 -0.72 1.40 1470.03 1.00 13 2 79 16 TRUE 0.28
colorectal cancer RAS_12-61 PIK3CA Any mutation 968 501 TMB overall 0.54 -0.36 1.46 1267.79 1.00 903 698 231 270 TRUE 0.62
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 985 231 TMB overall -0.52 -1.17 0.08 1406.39 1.00 1905 926 172 59 TRUE 0.95
uterine cancer RAS_12-61 PIK3CA Any mutation 198 548 TMB overall 0.26 -0.54 1.06 1593.32 1.00 443 79 429 119 TRUE 0.28
colorectal cancer RAS_12-61 ALK Any mutation 375 20 TMB quintile 4 0.30 -0.54 1.16 1449.81 1.00 408 363 8 12 TRUE 0.31
colorectal cancer RAS_12-61 ALK Any mutation 338 42 TMB quintile 5 -0.28 -0.84 0.34 1602.33 1.00 268 318 22 20 TRUE 0.45
colorectal cancer RAS_12-61 ALK Any mutation 40 45 TMB quintile 6 -0.57 -1.43 0.24 1646.99 1.00 78 32 37 8 TRUE 0.76
melanoma RAS_12-61 ALK Any mutation 162 76 TMB quintile 5 0.10 -0.41 0.59 1492.46 1.00 199 130 44 32 TRUE 0.17
melanoma RAS_12-61 ALK Any mutation 9 51 TMB quintile 6 0.69 -0.66 2.27 1374.16 1.00 33 2 44 7 TRUE 0.44
non-small cell lung cancer RAS_12-61 ALK Any mutation 159 13 TMB quintile 3 -0.76 -2.26 0.48 1378.69 1.00 457 157 11 2 TRUE 0.56
non-small cell lung cancer RAS_12-61 ALK Any mutation 267 22 TMB quintile 4 0.12 -0.75 0.95 1171.92 1.00 483 258 13 9 TRUE 0.11
non-small cell lung cancer RAS_12-61 ALK Any mutation 474 118 TMB quintile 5 -0.07 -0.48 0.30 1736.86 1.00 681 430 74 44 TRUE 0.15
colorectal cancer RAS_12-61 ALK Any mutation 753 107 TMB overall -0.16 -1.60 1.31 1395.06 1.00 754 713 67 40 TRUE 0.08
melanoma RAS_12-61 ALK Any mutation 171 127 TMB overall 0.37 -2.05 3.14 1483.54 1.00 232 132 88 39 TRUE 0.11
non-small cell lung cancer RAS_12-61 ALK Any mutation 901 164 TMB overall -0.50 -2.32 1.11 1568.68 1.00 1629 846 109 55 TRUE 0.25
colorectal cancer RAS_12-61 RNF43 Any mutation 192 12 TMB quintile 3 -1.31 -2.95 -0.10 1394.90 1.00 285 190 10 2 TRUE 1.16
colorectal cancer RAS_12-61 RNF43 Any mutation 375 30 TMB quintile 4 -0.69 -1.45 0.04 1481.60 1.00 397 365 20 10 TRUE 1.13
colorectal cancer RAS_12-61 RNF43 Any mutation 343 76 TMB quintile 5 -1.17 -1.72 -0.68 1528.82 1.00 243 321 54 22 TRUE 4.96
colorectal cancer RAS_12-61 RNF43 Any mutation 48 146 TMB quintile 6 -0.41 -1.09 0.30 1364.71 1.00 34 15 113 33 TRUE 0.61
colorectal cancer RAS_12-61 RNF43 Any mutation 958 264 TMB overall -0.91 -2.37 0.55 1499.23 1.00 959 891 197 67 TRUE 0.67
colorectal cancer RAS_12-61 PTEN Any mutation 375 29 TMB quintile 4 0.47 -0.27 1.22 1285.80 1.00 406 357 11 18 TRUE 0.65
colorectal cancer RAS_12-61 PTEN Any mutation 341 69 TMB quintile 5 -0.54 -1.02 -0.05 1277.28 1.00 260 313 41 28 TRUE 1.49
colorectal cancer RAS_12-61 PTEN Any mutation 46 80 TMB quintile 6 0.14 -0.53 0.76 1424.26 1.00 67 23 57 23 TRUE 0.18
non-small cell lung cancer RAS_12-61 PTEN Any mutation 159 17 TMB quintile 3 -1.66 -2.90 -0.58 1422.69 1.00 451 158 16 1 TRUE 2.32
non-small cell lung cancer RAS_12-61 PTEN Any mutation 267 27 TMB quintile 4 -1.95 -3.45 -0.96 1300.06 1.00 470 266 26 1 TRUE 2.76
non-small cell lung cancer RAS_12-61 PTEN Any mutation 474 75 TMB quintile 5 -1.20 -1.84 -0.65 1234.05 1.00 694 460 61 14 TRUE 4.08
uterine cancer RAS_12-61 PTEN Any mutation 14 16 TMB quintile 2 -0.24 -1.85 1.16 1383.54 1.00 117 13 15 1 TRUE 0.12
uterine cancer RAS_12-61 PTEN Any mutation 29 63 TMB quintile 3 0.67 -0.11 1.42 1462.31 1.00 177 18 52 11 TRUE 1.07
uterine cancer RAS_12-61 PTEN Any mutation 58 120 TMB quintile 4 0.31 -0.26 0.87 1526.91 1.00 119 29 91 29 TRUE 0.56
uterine cancer RAS_12-61 PTEN Any mutation 112 315 TMB quintile 5 0.65 0.07 1.31 1420.92 1.00 55 14 217 98 TRUE 1.44
uterine cancer RAS_12-61 PTEN Any mutation 21 103 TMB quintile 6 1.36 -0.01 3.10 1457.39 1.00 13 0 82 21 TRUE 1.04
colorectal cancer RAS_12-61 PTEN Any mutation 762 178 TMB overall 0.03 -1.55 1.60 1357.26 1.00 733 693 109 69 TRUE 0.01
non-small cell lung cancer RAS_12-61 PTEN Any mutation 900 119 TMB overall -1.61 -2.68 -0.74 1238.98 1.00 1615 884 103 16 TRUE 2.85
uterine cancer RAS_12-61 PTEN Any mutation 234 617 TMB overall 0.54 -0.74 1.74 1404.67 1.00 481 74 457 160 TRUE 0.41
colorectal cancer RAS_12-61 BCOR Any mutation 375 11 TMB quintile 4 0.38 -0.74 1.58 1353.59 1.00 412 368 4 7 FALSE 0.30
colorectal cancer RAS_12-61 BCOR Any mutation 338 39 TMB quintile 5 -0.20 -0.83 0.42 1424.36 1.00 271 319 20 19 FALSE 0.27
colorectal cancer RAS_12-61 BCOR Any mutation 43 57 TMB quintile 6 0.06 -0.66 0.76 1655.67 1.00 72 27 41 16 FALSE 0.06
non-small cell lung cancer RAS_12-61 BCOR Any mutation 267 22 TMB quintile 4 -0.13 -0.91 0.60 1407.33 1.00 481 260 15 7 FALSE 0.13
non-small cell lung cancer RAS_12-61 BCOR Any mutation 480 92 TMB quintile 5 0.24 -0.17 0.67 1348.61 1.00 700 439 51 41 FALSE 0.60
uterine cancer RAS_12-61 BCOR Any mutation 48 19 TMB quintile 4 0.37 -0.69 1.30 1507.87 1.00 168 42 13 6 FALSE 0.33
uterine cancer RAS_12-61 BCOR Any mutation 72 69 TMB quintile 5 0.30 -0.28 0.87 1492.73 1.00 149 50 47 22 FALSE 0.51
uterine cancer RAS_12-61 BCOR Any mutation 10 46 TMB quintile 6 -0.88 -2.14 0.35 1566.06 1.00 29 7 43 3 FALSE 0.78
colorectal cancer RAS_12-61 BCOR Any mutation 756 107 TMB overall 0.09 -1.58 1.87 1388.39 1.00 755 714 65 42 FALSE 0.04
non-small cell lung cancer RAS_12-61 BCOR Any mutation 747 114 TMB overall 0.05 -1.24 1.21 1581.56 1.00 1181 699 66 48 FALSE 0.03
uterine cancer RAS_12-61 BCOR Any mutation 130 134 TMB overall -0.07 -1.71 1.39 1493.84 1.00 346 99 103 31 FALSE 0.03
colorectal cancer RAS_12-61 CTNNB1 Any mutation 192 38 TMB quintile 3 0.74 0.15 1.36 1440.79 1.00 281 170 16 22 TRUE 1.75
colorectal cancer RAS_12-61 CTNNB1 Any mutation 376 35 TMB quintile 4 0.74 0.14 1.39 1440.72 1.00 405 352 11 24 TRUE 1.62
colorectal cancer RAS_12-61 CTNNB1 Any mutation 340 48 TMB quintile 5 0.31 -0.22 0.88 1332.99 1.00 269 311 19 29 TRUE 0.56
colorectal cancer RAS_12-61 CTNNB1 Any mutation 38 35 TMB quintile 6 0.43 -0.30 1.20 1534.22 1.00 81 27 24 11 TRUE 0.61
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 83 12 TMB quintile 2 -0.92 -2.07 0.04 1714.52 1.00 347 82 11 1 TRUE 1.06
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 159 22 TMB quintile 3 -1.32 -2.74 -0.36 1436.01 1.00 445 159 22 0 TRUE 1.50
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 269 33 TMB quintile 4 -0.40 -1.03 0.24 1276.11 1.00 474 258 22 11 TRUE 0.61
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 474 47 TMB quintile 5 -0.79 -1.44 -0.24 1505.23 1.00 713 463 36 11 TRUE 2.05
uterine cancer RAS_12-61 CTNNB1 Any mutation 26 28 TMB quintile 3 -1.98 -3.50 -0.76 1374.40 1.00 187 26 28 0 TRUE 2.36
uterine cancer RAS_12-61 CTNNB1 Any mutation 48 33 TMB quintile 4 -1.52 -2.65 -0.48 1549.11 1.00 151 45 30 3 TRUE 2.25
uterine cancer RAS_12-61 CTNNB1 Any mutation 70 61 TMB quintile 5 -1.80 -2.78 -0.96 1566.92 1.00 138 66 57 4 TRUE 4.03
uterine cancer RAS_12-61 CTNNB1 Any mutation 10 15 TMB quintile 6 -1.67 -3.08 -0.35 1520.12 1.00 39 9 14 1 TRUE 1.88
colorectal cancer RAS_12-61 CTNNB1 Any mutation 946 156 TMB overall 0.55 -0.24 1.39 1361.30 1.00 1036 860 70 86 TRUE 0.71
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 985 114 TMB overall -0.85 -1.69 -0.15 1310.85 1.00 1979 962 91 23 TRUE 1.52
uterine cancer RAS_12-61 CTNNB1 Any mutation 154 137 TMB overall -1.73 -2.81 -0.76 1443.68 1.00 515 146 129 8 TRUE 3.09
cancer of unknown primary RAS_12-61 ARID1A Any mutation 39 15 TMB quintile 4 0.08 -0.99 1.09 1419.68 1.00 93 34 10 5 TRUE 0.05
cancer of unknown primary RAS_12-61 ARID1A Any mutation 48 62 TMB quintile 5 -0.42 -1.15 0.30 1571.21 1.00 104 37 51 11 TRUE 0.62
cancer of unknown primary RAS_12-61 ARID1A Any mutation 7 16 TMB quintile 6 0.38 -0.96 1.81 1567.51 1.00 8 2 11 5 TRUE 0.23
colorectal cancer RAS_12-61 ARID1A Any mutation 376 32 TMB quintile 4 0.01 -0.69 0.72 1499.94 1.00 400 360 16 16 TRUE 0.01
colorectal cancer RAS_12-61 ARID1A Any mutation 346 116 TMB quintile 5 -0.90 -1.32 -0.49 1398.54 1.00 232 306 76 40 TRUE 4.74
colorectal cancer RAS_12-61 ARID1A Any mutation 52 155 TMB quintile 6 -0.12 -0.78 0.54 1445.74 1.00 39 14 117 38 TRUE 0.14
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 159 12 TMB quintile 3 -0.30 -1.48 0.73 1391.96 1.00 458 156 9 3 TRUE 0.23
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 267 56 TMB quintile 4 -0.24 -0.86 0.32 1252.07 1.00 459 250 39 17 TRUE 0.38
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 484 187 TMB quintile 5 -0.34 -0.66 -0.01 1442.97 1.00 632 424 127 60 TRUE 1.37
pancreatic cancer RAS_12-61 ARID1A Any mutation 277 13 TMB quintile 2 -0.81 -1.67 0.05 1670.97 1.00 64 269 5 8 TRUE 1.16
pancreatic cancer RAS_12-61 ARID1A Any mutation 458 44 TMB quintile 3 -0.18 -0.87 0.61 1488.26 1.00 60 420 6 38 TRUE 0.20
pancreatic cancer RAS_12-61 ARID1A Any mutation 245 45 TMB quintile 4 -0.07 -0.80 0.69 1242.73 1.00 33 207 7 38 TRUE 0.07
pancreatic cancer RAS_12-61 ARID1A Any mutation 39 17 TMB quintile 5 0.15 -0.84 1.13 1471.87 1.00 14 27 5 12 TRUE 0.12
uterine cancer RAS_12-61 ARID1A Any mutation 26 28 TMB quintile 3 0.30 -0.82 1.31 1489.28 1.00 192 22 24 4 TRUE 0.23
uterine cancer RAS_12-61 ARID1A Any mutation 52 77 TMB quintile 4 0.96 0.35 1.53 1485.78 1.00 135 26 51 26 TRUE 2.78
uterine cancer RAS_12-61 ARID1A Any mutation 99 307 TMB quintile 5 0.42 -0.17 1.03 1451.48 1.00 56 15 223 84 TRUE 0.77
uterine cancer RAS_12-61 ARID1A Any mutation 19 108 TMB quintile 6 1.37 -0.32 3.53 1501.13 1.00 9 0 89 19 TRUE 0.81
cancer of unknown primary RAS_12-61 ARID1A Any mutation 94 93 TMB overall 0.03 -1.23 1.37 1445.79 1.00 205 73 72 21 TRUE 0.02
colorectal cancer RAS_12-61 ARID1A Any mutation 774 303 TMB overall -0.33 -2.22 1.52 1271.87 1.00 671 680 209 94 TRUE 0.14
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 910 255 TMB overall -0.26 -1.43 0.92 1595.70 1.00 1549 830 175 80 TRUE 0.18
pancreatic cancer RAS_12-61 ARID1A Any mutation 1019 119 TMB overall -0.23 -1.08 0.66 1542.74 1.00 171 923 23 96 TRUE 0.22
uterine cancer RAS_12-61 ARID1A Any mutation 196 520 TMB overall 0.76 -0.83 2.50 1433.39 1.00 392 63 387 133 TRUE 0.44
colorectal cancer RAS_12-61 PIK3R1 Any mutation 375 22 TMB quintile 4 0.05 -0.74 0.87 1622.91 1.00 406 364 11 11 TRUE 0.05
colorectal cancer RAS_12-61 PIK3R1 Any mutation 339 29 TMB quintile 5 0.15 -0.54 0.87 1561.82 1.00 278 322 12 17 TRUE 0.17
colorectal cancer RAS_12-61 PIK3R1 Any mutation 41 56 TMB quintile 6 0.22 -0.49 0.90 1423.68 1.00 75 25 40 16 TRUE 0.27
uterine cancer RAS_12-61 PIK3R1 Any mutation 26 40 TMB quintile 3 -0.96 -2.16 0.04 1474.23 1.00 181 24 38 2 TRUE 1.01
uterine cancer RAS_12-61 PIK3R1 Any mutation 50 68 TMB quintile 4 -0.74 -1.47 -0.01 1493.97 1.00 132 41 59 9 TRUE 1.32
uterine cancer RAS_12-61 PIK3R1 Any mutation 82 117 TMB quintile 5 0.05 -0.44 0.56 1374.08 1.00 127 47 82 35 TRUE 0.08
uterine cancer RAS_12-61 PIK3R1 Any mutation 10 37 TMB quintile 6 -1.45 -2.92 -0.23 1557.87 1.00 26 9 36 1 TRUE 1.44
colorectal cancer RAS_12-61 PIK3R1 Any mutation 755 107 TMB overall 0.15 -1.45 1.67 1537.68 1.00 759 711 63 44 TRUE 0.07
uterine cancer RAS_12-61 PIK3R1 Any mutation 168 262 TMB overall -0.77 -1.77 0.17 1520.38 1.00 466 121 215 47 TRUE 0.92
melanoma RAS_12-61 IKZF1 Any mutation 162 57 TMB quintile 5 0.02 -0.55 0.55 1470.11 1.00 210 139 34 23 TRUE 0.02
melanoma RAS_12-61 IKZF1 Any mutation 12 44 TMB quintile 6 0.58 -0.52 1.84 1455.51 1.00 38 4 36 8 TRUE 0.48
melanoma RAS_12-61 IKZF1 Any mutation 174 101 TMB overall 0.28 -1.94 2.59 1645.64 1.00 248 143 70 31 TRUE 0.09
colorectal cancer RAS_12-61 FAT1 Any mutation 375 17 TMB quintile 4 -0.39 -1.40 0.54 1705.48 1.00 407 368 10 7 FALSE 0.37
colorectal cancer RAS_12-61 FAT1 Any mutation 340 64 TMB quintile 5 -1.04 -1.58 -0.50 1416.09 1.00 251 320 44 20 FALSE 3.86
colorectal cancer RAS_12-61 FAT1 Any mutation 54 145 TMB quintile 6 -0.30 -0.92 0.35 1657.29 1.00 44 19 110 35 FALSE 0.44
melanoma RAS_12-61 FAT1 Any mutation 163 86 TMB quintile 5 0.09 -0.38 0.56 1532.54 1.00 195 127 50 36 FALSE 0.15
melanoma RAS_12-61 FAT1 Any mutation 11 50 TMB quintile 6 0.61 -0.58 1.83 1527.28 1.00 36 3 42 8 FALSE 0.49
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 159 16 TMB quintile 3 0.07 -1.06 1.14 1426.96 1.00 456 154 11 5 FALSE 0.05
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 267 43 TMB quintile 4 -0.49 -1.19 0.19 1472.28 1.00 468 256 32 11 FALSE 0.79
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 479 227 TMB quintile 5 -0.22 -0.52 0.08 1289.22 1.00 618 401 149 78 FALSE 0.83
uterine cancer RAS_12-61 FAT1 Any mutation 71 49 TMB quintile 5 -0.27 -1.03 0.42 1533.54 1.00 165 60 38 11 FALSE 0.34
uterine cancer RAS_12-61 FAT1 Any mutation 15 115 TMB quintile 6 -0.51 -1.72 0.88 1399.44 1.00 14 3 103 12 FALSE 0.35
colorectal cancer RAS_12-61 FAT1 Any mutation 769 226 TMB overall -0.59 -2.72 1.43 1470.64 1.00 702 707 164 62 FALSE 0.25
melanoma RAS_12-61 FAT1 Any mutation 174 136 TMB overall 0.34 -1.94 2.54 1447.46 1.00 231 130 92 44 FALSE 0.12
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 906 300 TMB overall -0.20 -1.84 1.45 1397.78 1.00 1549 811 205 95 FALSE 0.09
uterine cancer RAS_12-61 FAT1 Any mutation 86 164 TMB overall -0.38 -3.24 2.42 1320.37 1.00 179 63 141 23 FALSE 0.10
colorectal cancer RAS_12-61 CIC Any mutation 375 17 TMB quintile 4 0.05 -0.87 1.02 1399.58 1.00 409 366 8 9 TRUE 0.04
colorectal cancer RAS_12-61 CIC Any mutation 341 40 TMB quintile 5 -0.62 -1.31 0.01 1198.72 1.00 266 325 24 16 TRUE 1.19
colorectal cancer RAS_12-61 CIC Any mutation 40 79 TMB quintile 6 -0.53 -1.19 0.14 1450.18 1.00 61 25 64 15 TRUE 0.87
colorectal cancer RAS_12-61 CIC Any mutation 756 136 TMB overall -0.38 -2.06 1.45 1516.20 1.00 736 716 96 40 TRUE 0.18
colorectal cancer RAS_12-61 NCOR1 Any mutation 375 16 TMB quintile 4 -0.29 -1.23 0.68 1680.75 1.00 407 368 9 7 FALSE 0.26
colorectal cancer RAS_12-61 NCOR1 Any mutation 339 32 TMB quintile 5 -0.96 -1.73 -0.28 1421.65 1.00 271 329 22 10 FALSE 1.98
colorectal cancer RAS_12-61 NCOR1 Any mutation 42 81 TMB quintile 6 0.23 -0.47 0.87 1219.03 1.00 62 19 58 23 FALSE 0.29
non-small cell lung cancer RAS_12-61 NCOR1 Any mutation 267 21 TMB quintile 4 -0.76 -1.74 0.01 1356.98 1.00 479 263 17 4 FALSE 1.08
non-small cell lung cancer RAS_12-61 NCOR1 Any mutation 477 71 TMB quintile 5 -0.46 -0.94 0.04 1364.70 1.00 705 456 50 21 FALSE 1.13
colorectal cancer RAS_12-61 NCOR1 Any mutation 756 129 TMB overall -0.35 -2.11 1.50 1257.91 1.00 740 716 89 40 FALSE 0.16
non-small cell lung cancer RAS_12-61 NCOR1 Any mutation 744 92 TMB overall -0.60 -1.81 0.51 1517.25 1.00 1184 719 67 25 FALSE 0.54
colorectal cancer RAS_12-61 POLE Any mutation 338 38 TMB quintile 5 -0.75 -1.40 -0.07 1599.44 1.00 266 324 24 14 TRUE 1.56
colorectal cancer RAS_12-61 POLE Any mutation 44 93 TMB quintile 6 0.17 -0.54 0.87 1484.56 1.00 57 18 67 26 TRUE 0.20
non-small cell lung cancer RAS_12-61 POLE Any mutation 267 20 TMB quintile 4 0.12 -0.69 0.92 1591.05 1.00 483 259 12 8 TRUE 0.11
non-small cell lung cancer RAS_12-61 POLE Any mutation 476 102 TMB quintile 5 0.31 -0.12 0.70 1578.61 1.00 698 430 56 46 TRUE 0.88
uterine cancer RAS_12-61 POLE Any mutation 70 24 TMB quintile 5 -0.16 -1.18 0.72 1691.61 1.00 176 64 18 6 TRUE 0.13
uterine cancer RAS_12-61 POLE Any mutation 14 80 TMB quintile 6 0.07 -1.17 1.48 1433.02 1.00 20 3 69 11 TRUE 0.04
colorectal cancer RAS_12-61 POLE Any mutation 382 131 TMB overall -0.28 -2.77 2.32 1443.53 1.00 323 342 91 40 TRUE 0.08
non-small cell lung cancer RAS_12-61 POLE Any mutation 743 122 TMB overall 0.19 -1.19 1.53 1483.40 1.00 1181 689 68 54 TRUE 0.11
uterine cancer RAS_12-61 POLE Any mutation 84 104 TMB overall -0.08 -3.08 2.64 1514.27 1.00 196 67 87 17 TRUE 0.02
non-small cell lung cancer RAS_12-61 NOTCH2 Any mutation 268 16 TMB quintile 4 0.31 -0.60 1.35 1389.23 1.00 484 260 8 8 TRUE 0.27
non-small cell lung cancer RAS_12-61 NOTCH2 Any mutation 473 81 TMB quintile 5 -0.44 -0.92 0.04 1396.05 1.00 694 450 58 23 TRUE 1.12
non-small cell lung cancer RAS_12-61 NOTCH2 Any mutation 741 97 TMB overall -0.04 -1.79 2.02 1654.11 1.00 1178 710 66 31 TRUE 0.02
colorectal cancer RAS_12-61 TGFBR2 Any mutation 339 47 TMB quintile 5 -0.33 -0.90 0.24 1476.24 1.00 267 317 25 22 TRUE 0.59
colorectal cancer RAS_12-61 TGFBR2 Any mutation 38 57 TMB quintile 6 -0.20 -0.92 0.54 1579.67 1.00 62 24 43 14 TRUE 0.23
colorectal cancer RAS_12-61 TGFBR2 Any mutation 377 104 TMB overall -0.25 -2.18 1.77 1462.49 1.00 329 341 68 36 TRUE 0.10
colorectal cancer RAS_12-61 KMT2A Any mutation 375 16 TMB quintile 4 -0.50 -1.48 0.41 1490.97 1.00 406 369 10 6 FALSE 0.53
colorectal cancer RAS_12-61 KMT2A Any mutation 339 43 TMB quintile 5 -0.42 -1.06 0.14 1374.23 1.00 267 320 24 19 FALSE 0.77
colorectal cancer RAS_12-61 KMT2A Any mutation 44 84 TMB quintile 6 -0.08 -0.75 0.57 1602.76 1.00 65 23 63 21 FALSE 0.08
melanoma RAS_12-61 KMT2A Any mutation 162 69 TMB quintile 5 -0.18 -0.71 0.33 1402.62 1.00 204 137 44 25 FALSE 0.30
melanoma RAS_12-61 KMT2A Any mutation 9 62 TMB quintile 6 0.41 -0.90 1.91 1442.95 1.00 30 2 55 7 FALSE 0.24
non-small cell lung cancer RAS_12-61 KMT2A Any mutation 267 16 TMB quintile 4 -0.32 -1.32 0.62 1423.57 1.00 484 262 11 5 FALSE 0.31
non-small cell lung cancer RAS_12-61 KMT2A Any mutation 475 80 TMB quintile 5 -0.34 -0.83 0.12 1450.02 1.00 698 450 55 25 FALSE 0.77
uterine cancer RAS_12-61 KMT2A Any mutation 70 27 TMB quintile 5 0.04 -0.87 0.89 1365.42 1.00 174 62 19 8 FALSE 0.04
uterine cancer RAS_12-61 KMT2A Any mutation 13 76 TMB quintile 6 -0.51 -1.66 0.60 1265.95 1.00 24 5 68 8 FALSE 0.42
colorectal cancer RAS_12-61 KMT2A Any mutation 758 143 TMB overall -0.36 -2.10 1.34 1486.57 1.00 738 712 97 46 FALSE 0.17
melanoma RAS_12-61 KMT2A Any mutation 171 131 TMB overall 0.14 -2.38 2.83 1481.36 1.00 234 139 99 32 FALSE 0.04
non-small cell lung cancer RAS_12-61 KMT2A Any mutation 742 96 TMB overall -0.32 -1.80 1.04 1466.50 1.00 1182 712 66 30 FALSE 0.19
uterine cancer RAS_12-61 KMT2A Any mutation 83 103 TMB overall -0.26 -3.23 2.44 1332.12 1.00 198 67 87 16 FALSE 0.07
melanoma RAS_12-61 PAK7 Any mutation 161 135 TMB quintile 5 -0.34 -0.78 0.06 1534.96 1.00 151 113 87 48 FALSE 0.95
melanoma RAS_12-61 PAK7 Any mutation 10 75 TMB quintile 6 -1.75 -3.06 -0.54 1375.69 1.00 15 6 71 4 FALSE 2.09
non-small cell lung cancer RAS_12-61 PAK7 Any mutation 267 13 TMB quintile 4 0.00 -1.11 0.96 1586.05 1.00 484 262 8 5 FALSE 0.00
non-small cell lung cancer RAS_12-61 PAK7 Any mutation 474 95 TMB quintile 5 0.08 -0.34 0.51 1481.88 1.00 695 436 57 38 FALSE 0.14
melanoma RAS_12-61 PAK7 Any mutation 171 210 TMB overall -0.98 -3.36 1.46 1497.32 1.00 166 119 158 52 FALSE 0.39
non-small cell lung cancer RAS_12-61 PAK7 Any mutation 741 108 TMB overall 0.03 -1.65 1.57 1469.29 1.00 1179 698 65 43 FALSE 0.01
non-small cell lung cancer RAS_12-61 STAG2 Any mutation 267 19 TMB quintile 4 0.01 -0.74 0.76 1278.82 1.00 483 260 12 7 TRUE 0.01
non-small cell lung cancer RAS_12-61 STAG2 Any mutation 475 76 TMB quintile 5 0.17 -0.29 0.61 1547.47 1.00 710 443 44 32 TRUE 0.34
non-small cell lung cancer RAS_12-61 STAG2 Any mutation 742 95 TMB overall 0.11 -0.99 1.35 1550.08 1.00 1193 703 56 39 TRUE 0.07
melanoma RAS_12-61 TERT Any mutation 19 17 TMB quintile 2 1.42 0.37 2.45 1529.57 1.00 95 12 10 7 TRUE 2.13
melanoma RAS_12-61 TERT Any mutation 17 29 TMB quintile 3 0.25 -0.84 1.22 1444.76 1.00 71 12 24 5 TRUE 0.19
melanoma RAS_12-61 TERT Any mutation 24 57 TMB quintile 4 0.78 -0.14 1.71 1519.16 1.00 42 8 41 16 TRUE 1.06
melanoma RAS_12-61 TERT Any mutation 180 396 TMB quintile 5 0.61 0.06 1.20 1539.30 1.00 40 17 233 163 TRUE 1.38
melanoma RAS_12-61 TERT Any mutation 17 106 TMB quintile 6 1.23 -0.23 3.17 1579.68 1.00 12 0 89 17 TRUE 0.79
non-small cell lung cancer RAS_12-61 TERT Any mutation 160 13 TMB quintile 3 0.42 -0.45 1.44 1328.23 1.00 460 154 7 6 TRUE 0.42
non-small cell lung cancer RAS_12-61 TERT Any mutation 267 34 TMB quintile 4 0.16 -0.47 0.76 1511.44 1.00 475 254 21 13 TRUE 0.20
non-small cell lung cancer RAS_12-61 TERT Any mutation 476 98 TMB quintile 5 0.03 -0.40 0.43 1492.89 1.00 693 439 61 37 TRUE 0.05
melanoma RAS_12-61 TERT Any mutation 257 605 TMB overall 0.84 -0.44 2.14 1363.30 1.00 260 49 397 208 TRUE 0.71
non-small cell lung cancer RAS_12-61 TERT Any mutation 903 145 TMB overall 0.21 -0.66 1.15 1475.23 1.00 1628 847 89 56 TRUE 0.19
colorectal cancer RAS_12-61 BRCA2 Any mutation 375 21 TMB quintile 4 -0.29 -1.18 0.61 1522.67 1.00 404 366 12 9 TRUE 0.30
colorectal cancer RAS_12-61 BRCA2 Any mutation 343 48 TMB quintile 5 -0.20 -0.77 0.38 1541.17 1.00 267 319 24 24 TRUE 0.31
colorectal cancer RAS_12-61 BRCA2 Any mutation 46 116 TMB quintile 6 -0.55 -1.23 0.10 1445.70 1.00 57 24 94 22 TRUE 0.97
non-small cell lung cancer RAS_12-61 BRCA2 Any mutation 267 23 TMB quintile 4 -0.29 -1.20 0.61 1200.42 1.00 480 260 16 7 TRUE 0.27
non-small cell lung cancer RAS_12-61 BRCA2 Any mutation 476 89 TMB quintile 5 -0.36 -0.83 0.11 1497.73 1.00 691 448 61 28 TRUE 0.90
uterine cancer RAS_12-61 BRCA2 Any mutation 70 29 TMB quintile 5 -0.74 -1.83 0.26 1587.02 1.00 168 65 24 5 TRUE 0.82
uterine cancer RAS_12-61 BRCA2 Any mutation 12 93 TMB quintile 6 -1.04 -2.18 0.25 1384.13 1.00 21 5 86 7 TRUE 1.03
colorectal cancer RAS_12-61 BRCA2 Any mutation 764 185 TMB overall -0.34 -2.07 1.34 1427.76 1.00 728 709 130 55 TRUE 0.16
non-small cell lung cancer RAS_12-61 BRCA2 Any mutation 744 126 TMB overall -0.19 -2.55 2.31 1320.41 1.00 1180 708 90 36 TRUE 0.06
uterine cancer RAS_12-61 BRCA2 Any mutation 82 122 TMB overall -0.82 -3.65 2.06 1523.35 1.00 189 70 110 12 TRUE 0.26
colorectal cancer RAS_12-61 NOTCH3 Any mutation 192 12 TMB quintile 3 0.51 -0.58 1.62 1603.70 1.00 290 185 5 7 TRUE 0.44
colorectal cancer RAS_12-61 NOTCH3 Any mutation 375 17 TMB quintile 4 0.09 -0.90 1.00 1538.23 1.00 408 366 8 9 TRUE 0.07
colorectal cancer RAS_12-61 NOTCH3 Any mutation 338 50 TMB quintile 5 -0.59 -1.19 -0.02 1398.78 1.00 263 318 30 20 TRUE 1.35
colorectal cancer RAS_12-61 NOTCH3 Any mutation 40 120 TMB quintile 6 -0.48 -1.23 0.19 1363.50 1.00 42 17 97 23 TRUE 0.74
melanoma RAS_12-61 NOTCH3 Any mutation 160 67 TMB quintile 5 -0.58 -1.14 0.00 1403.57 1.00 195 140 47 20 TRUE 1.28
melanoma RAS_12-61 NOTCH3 Any mutation 9 57 TMB quintile 6 -1.30 -2.72 0.00 1424.44 1.00 29 6 54 3 TRUE 1.21
non-small cell lung cancer RAS_12-61 NOTCH3 Any mutation 267 21 TMB quintile 4 -0.14 -1.09 0.74 1640.75 1.00 482 260 14 7 TRUE 0.12
non-small cell lung cancer RAS_12-61 NOTCH3 Any mutation 474 82 TMB quintile 5 -0.21 -0.68 0.24 1597.89 1.00 700 446 54 28 TRUE 0.43
colorectal cancer RAS_12-61 NOTCH3 Any mutation 945 199 TMB overall -0.10 -1.71 1.51 1516.18 1.00 1003 886 140 59 TRUE 0.04
melanoma RAS_12-61 NOTCH3 Any mutation 169 124 TMB overall -0.93 -3.20 1.40 1519.65 1.00 224 146 101 23 TRUE 0.38
non-small cell lung cancer RAS_12-61 NOTCH3 Any mutation 742 114 TMB overall -0.03 -2.07 2.21 1623.59 1.00 1191 706 78 36 TRUE 0.01
colorectal cancer RAS_12-61 NOTCH4 Any mutation 367 21 TMB quintile 4 -0.17 -1.02 0.68 1346.97 1.00 396 357 11 10 TRUE 0.17
colorectal cancer RAS_12-61 NOTCH4 Any mutation 320 37 TMB quintile 5 -1.06 -1.73 -0.39 1326.36 1.00 244 309 26 11 TRUE 2.62
colorectal cancer RAS_12-61 NOTCH4 Any mutation 42 59 TMB quintile 6 -0.34 -1.06 0.39 1498.39 1.00 65 28 45 14 TRUE 0.45
melanoma RAS_12-61 NOTCH4 Any mutation 157 81 TMB quintile 5 0.06 -0.42 0.55 1468.20 1.00 184 123 47 34 TRUE 0.09
melanoma RAS_12-61 NOTCH4 Any mutation 12 64 TMB quintile 6 0.47 -0.86 2.06 1549.88 1.00 20 2 54 10 TRUE 0.28
non-small cell lung cancer RAS_12-61 NOTCH4 Any mutation 267 17 TMB quintile 4 -0.87 -2.02 0.10 1462.26 1.00 478 264 14 3 TRUE 0.95
non-small cell lung cancer RAS_12-61 NOTCH4 Any mutation 473 107 TMB quintile 5 -0.26 -0.65 0.12 1690.75 1.00 678 437 71 36 TRUE 0.70
colorectal cancer RAS_12-61 NOTCH4 Any mutation 729 117 TMB overall -0.51 -1.98 1.08 1483.09 1.00 705 694 82 35 TRUE 0.30
melanoma RAS_12-61 NOTCH4 Any mutation 169 145 TMB overall 0.27 -2.30 2.97 1523.83 1.00 204 125 101 44 TRUE 0.08
non-small cell lung cancer RAS_12-61 NOTCH4 Any mutation 740 124 TMB overall -0.53 -2.32 1.32 1555.79 1.00 1156 701 85 39 TRUE 0.27
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 83 12 TMB quintile 2 0.80 -0.27 1.82 1409.37 1.00 351 78 7 5 FALSE 0.90
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 159 50 TMB quintile 3 1.10 0.53 1.66 1483.75 1.00 442 134 25 25 FALSE 3.82
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 269 129 TMB quintile 4 0.62 0.24 0.99 1264.15 1.00 429 208 68 61 FALSE 2.96
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 480 336 TMB quintile 5 -0.14 -0.41 0.14 1380.38 1.00 545 360 216 120 FALSE 0.52
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 991 527 TMB overall 0.59 -0.44 1.56 1434.58 1.00 1767 780 316 211 FALSE 0.58
non-small cell lung cancer RAS_12-61 KDM5C Any mutation 267 16 TMB quintile 4 -0.16 -1.07 0.68 1346.98 1.00 484 262 11 5 FALSE 0.14
non-small cell lung cancer RAS_12-61 KDM5C Any mutation 476 70 TMB quintile 5 0.22 -0.27 0.71 1261.96 1.00 713 445 39 31 FALSE 0.43
non-small cell lung cancer RAS_12-61 KDM5C Any mutation 743 86 TMB overall 0.05 -1.31 1.31 1322.91 1.00 1197 707 50 36 FALSE 0.03
melanoma RAS_12-61 CDKN2A Any mutation 164 80 TMB quintile 5 0.01 -0.49 0.48 1441.90 1.00 195 131 47 33 TRUE 0.01
melanoma RAS_12-61 CDKN2A Any mutation 8 34 TMB quintile 6 -1.00 -2.57 0.30 1467.97 1.00 32 6 32 2 TRUE 0.79
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 159 33 TMB quintile 3 0.15 -0.62 0.83 1322.42 1.00 446 148 22 11 TRUE 0.17
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 267 43 TMB quintile 4 -0.29 -0.93 0.33 1458.57 1.00 466 254 30 13 TRUE 0.44
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 480 178 TMB quintile 5 -0.83 -1.19 -0.47 1513.76 1.00 621 440 138 40 TRUE 4.97
pancreatic cancer RAS_12-61 CDKN2A Any mutation 277 34 TMB quintile 2 1.44 0.57 2.55 1396.31 1.00 68 244 1 33 TRUE 2.35
pancreatic cancer RAS_12-61 CDKN2A Any mutation 465 146 TMB quintile 3 1.75 1.02 2.56 1468.83 1.00 61 324 5 141 TRUE 5.04
pancreatic cancer RAS_12-61 CDKN2A Any mutation 248 96 TMB quintile 4 1.77 0.98 2.65 1512.23 1.00 35 157 5 91 TRUE 4.58
melanoma RAS_12-61 CDKN2A Any mutation 172 114 TMB overall -0.48 -2.76 1.51 1477.56 1.00 227 137 79 35 TRUE 0.18
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 906 254 TMB overall -0.30 -1.27 0.65 1390.78 1.00 1533 842 190 64 TRUE 0.28
pancreatic cancer RAS_12-61 CDKN2A Any mutation 990 276 TMB overall 1.64 0.70 2.73 1314.82 1.00 164 725 11 265 TRUE 2.92
non-small cell lung cancer RAS_12-61 EPHB1 Any mutation 267 19 TMB quintile 4 0.13 -0.84 1.03 1516.81 1.00 484 259 11 8 FALSE 0.11
non-small cell lung cancer RAS_12-61 EPHB1 Any mutation 476 117 TMB quintile 5 -0.73 -1.18 -0.30 1525.33 1.00 665 447 88 29 FALSE 2.95
non-small cell lung cancer RAS_12-61 EPHB1 Any mutation 744 152 TMB overall -0.85 -3.55 1.57 1506.13 1.00 1157 707 115 37 FALSE 0.30
uterine cancer RAS_12-61 PPP2R1A Any mutation 26 44 TMB quintile 3 -0.28 -1.21 0.62 1529.93 1.00 177 21 39 5 FALSE 0.26
uterine cancer RAS_12-61 PPP2R1A Any mutation 48 46 TMB quintile 4 -0.50 -1.29 0.24 1414.00 1.00 143 41 39 7 FALSE 0.71
uterine cancer RAS_12-61 PPP2R1A Any mutation 70 25 TMB quintile 5 -0.54 -1.45 0.25 1188.21 1.00 172 65 20 5 FALSE 0.68
uterine cancer RAS_12-61 PPP2R1A Any mutation 11 30 TMB quintile 6 -0.81 -2.05 0.24 1514.36 1.00 35 9 28 2 FALSE 0.81
uterine cancer RAS_12-61 PPP2R1A Any mutation 155 145 TMB overall -0.54 -1.39 0.32 1469.52 1.00 527 136 126 19 FALSE 0.67
colorectal cancer RAS_12-61 ERBB3 Any mutation 376 27 TMB quintile 4 -0.16 -0.91 0.55 1278.29 1.00 401 364 15 12 TRUE 0.18
colorectal cancer RAS_12-61 ERBB3 Any mutation 338 39 TMB quintile 5 0.19 -0.46 0.81 1504.74 1.00 273 315 16 23 TRUE 0.25
colorectal cancer RAS_12-61 ERBB3 Any mutation 39 51 TMB quintile 6 0.41 -0.33 1.14 1359.55 1.00 79 23 35 16 TRUE 0.56
colorectal cancer RAS_12-61 ERBB3 Any mutation 753 117 TMB overall 0.14 -1.14 1.54 1434.23 1.00 753 702 66 51 TRUE 0.07
colorectal cancer RAS_12-61 SMAD4 Any mutation 193 51 TMB quintile 3 0.06 -0.41 0.53 1468.86 1.00 267 171 29 22 TRUE 0.10
colorectal cancer RAS_12-61 SMAD4 Any mutation 378 129 TMB quintile 4 0.22 -0.14 0.56 1493.11 1.00 358 310 61 68 TRUE 0.65
colorectal cancer RAS_12-61 SMAD4 Any mutation 347 138 TMB quintile 5 0.06 -0.30 0.42 1339.39 1.00 232 273 64 74 TRUE 0.12
colorectal cancer RAS_12-61 SMAD4 Any mutation 39 31 TMB quintile 6 -0.01 -0.65 0.62 1598.62 1.00 86 31 23 8 TRUE 0.01
non-small cell lung cancer RAS_12-61 SMAD4 Any mutation 159 21 TMB quintile 3 -0.60 -1.35 0.11 1474.14 1.00 449 156 18 3 TRUE 0.97
non-small cell lung cancer RAS_12-61 SMAD4 Any mutation 267 36 TMB quintile 4 -0.56 -1.19 0.03 1587.08 1.00 471 259 28 8 TRUE 1.12
non-small cell lung cancer RAS_12-61 SMAD4 Any mutation 474 49 TMB quintile 5 -0.42 -0.93 0.10 1468.71 1.00 716 458 33 16 TRUE 0.92
pancreatic cancer RAS_12-61 SMAD4 Any mutation 277 37 TMB quintile 2 0.52 -0.21 1.32 1337.50 1.00 65 244 4 33 TRUE 0.73
pancreatic cancer RAS_12-61 SMAD4 Any mutation 461 119 TMB quintile 3 0.56 -0.01 1.15 1651.18 1.00 55 353 11 108 TRUE 1.20
pancreatic cancer RAS_12-61 SMAD4 Any mutation 242 82 TMB quintile 4 0.94 0.28 1.66 1478.18 1.00 34 166 6 76 TRUE 2.04
pancreatic cancer RAS_12-61 SMAD4 Any mutation 40 25 TMB quintile 5 0.99 0.19 1.91 1400.62 1.00 13 20 5 20 TRUE 1.58
colorectal cancer RAS_12-61 SMAD4 Any mutation 957 349 TMB overall 0.08 -0.48 0.65 1578.40 1.00 943 785 177 172 TRUE 0.11
non-small cell lung cancer RAS_12-61 SMAD4 Any mutation 900 106 TMB overall -0.53 -1.16 0.10 1570.43 1.00 1636 873 79 27 TRUE 0.99
pancreatic cancer RAS_12-61 SMAD4 Any mutation 1020 263 TMB overall 0.75 -0.03 1.55 1228.21 1.00 167 783 26 237 TRUE 1.20
colorectal cancer RAS_12-61 ATM Any mutation 379 46 TMB quintile 4 0.30 -0.26 0.86 1618.46 1.00 397 353 20 26 TRUE 0.51
colorectal cancer RAS_12-61 ATM Any mutation 344 78 TMB quintile 5 -0.24 -0.72 0.21 1652.37 1.00 251 306 40 38 TRUE 0.51
colorectal cancer RAS_12-61 ATM Any mutation 44 94 TMB quintile 6 -0.08 -0.73 0.57 1337.79 1.00 65 22 72 22 TRUE 0.09
non-small cell lung cancer RAS_12-61 ATM Any mutation 83 15 TMB quintile 2 0.93 0.09 1.72 1567.32 1.00 350 77 9 6 TRUE 1.63
non-small cell lung cancer RAS_12-61 ATM Any mutation 159 20 TMB quintile 3 0.95 0.22 1.67 1531.45 1.00 457 149 10 10 TRUE 2.07
non-small cell lung cancer RAS_12-61 ATM Any mutation 275 76 TMB quintile 4 1.25 0.79 1.69 1531.37 1.00 470 227 28 48 TRUE 7.17
non-small cell lung cancer RAS_12-61 ATM Any mutation 488 166 TMB quintile 5 0.75 0.42 1.08 1475.29 1.00 678 399 77 89 TRUE 5.17
uterine cancer RAS_12-61 ATM Any mutation 71 46 TMB quintile 5 -0.38 -1.17 0.32 1495.95 1.00 164 61 36 10 TRUE 0.50
uterine cancer RAS_12-61 ATM Any mutation 13 101 TMB quintile 6 -0.75 -1.96 0.49 1661.20 1.00 17 4 92 9 TRUE 0.63
colorectal cancer RAS_12-61 ATM Any mutation 767 218 TMB overall -0.02 -1.44 1.43 1236.36 1.00 713 681 132 86 TRUE 0.01
non-small cell lung cancer RAS_12-61 ATM Any mutation 1005 277 TMB overall 0.98 0.31 1.70 1533.01 1.00 1955 852 124 153 TRUE 2.23
uterine cancer RAS_12-61 ATM Any mutation 84 147 TMB overall -0.52 -3.27 2.27 1567.72 1.00 181 65 128 19 TRUE 0.15
non-small cell lung cancer RAS_12-61 RB1 Any mutation 159 33 TMB quintile 3 -1.34 -2.24 -0.60 1442.26 1.00 436 157 31 2 TRUE 2.81
non-small cell lung cancer RAS_12-61 RB1 Any mutation 267 50 TMB quintile 4 -1.11 -1.77 -0.49 1390.11 1.00 453 259 42 8 TRUE 3.18
non-small cell lung cancer RAS_12-61 RB1 Any mutation 474 124 TMB quintile 5 -0.93 -1.36 -0.53 1506.99 1.00 657 447 97 27 TRUE 4.80
non-small cell lung cancer RAS_12-61 RB1 Any mutation 900 207 TMB overall -1.14 -1.85 -0.45 1370.10 1.00 1546 863 170 37 TRUE 2.88
cancer of unknown primary RAS_12-61 KMT2D Any mutation 40 14 TMB quintile 3 -1.65 -3.39 -0.14 1477.87 1.00 92 39 13 1 FALSE 1.26
cancer of unknown primary RAS_12-61 KMT2D Any mutation 39 11 TMB quintile 4 -0.37 -1.76 0.91 1453.61 1.00 95 36 8 3 FALSE 0.23
cancer of unknown primary RAS_12-61 KMT2D Any mutation 46 67 TMB quintile 5 -0.80 -1.56 -0.07 1554.13 1.00 95 36 57 10 FALSE 1.42
colorectal cancer RAS_12-61 KMT2D Any mutation 375 27 TMB quintile 4 -0.69 -1.53 0.08 1494.38 1.00 399 366 18 9 FALSE 1.01
colorectal cancer RAS_12-61 KMT2D Any mutation 344 104 TMB quintile 5 -0.78 -1.21 -0.35 1473.47 1.00 245 306 66 38 FALSE 3.34
colorectal cancer RAS_12-61 KMT2D Any mutation 63 245 TMB quintile 6 -0.36 -1.30 0.64 1467.52 1.00 13 6 188 57 FALSE 0.33
melanoma RAS_12-61 KMT2D Any mutation 170 112 TMB quintile 5 0.06 -0.36 0.50 1430.92 1.00 187 124 66 46 FALSE 0.11
melanoma RAS_12-61 KMT2D Any mutation 17 91 TMB quintile 6 1.38 -0.03 3.33 1540.39 1.00 27 1 75 16 FALSE 0.96
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 159 15 TMB quintile 3 -0.21 -1.41 0.88 1448.20 1.00 456 155 11 4 FALSE 0.14
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 267 42 TMB quintile 4 -0.26 -0.94 0.36 1423.99 1.00 469 254 29 13 FALSE 0.35
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 481 251 TMB quintile 5 -0.77 -1.09 -0.45 1304.80 1.00 594 419 189 62 FALSE 5.57
uterine cancer RAS_12-61 KMT2D Any mutation 48 14 TMB quintile 4 -0.72 -2.38 0.63 1577.62 1.00 170 46 12 2 FALSE 0.46
uterine cancer RAS_12-61 KMT2D Any mutation 75 129 TMB quintile 5 -0.34 -0.86 0.18 1566.12 1.00 113 46 100 29 FALSE 0.71
uterine cancer RAS_12-61 KMT2D Any mutation 15 109 TMB quintile 6 -0.80 -1.98 0.38 1409.18 1.00 14 4 98 11 FALSE 0.73
cancer of unknown primary RAS_12-61 KMT2D Any mutation 130 123 TMB overall -0.84 -2.44 0.79 1706.85 1.00 285 112 105 18 FALSE 0.51
colorectal cancer RAS_12-61 KMT2D Any mutation 782 376 TMB overall -0.62 -3.21 1.66 1492.66 1.00 657 678 272 104 FALSE 0.22
melanoma RAS_12-61 KMT2D Any mutation 187 203 TMB overall 0.71 -1.98 3.79 1598.72 1.00 214 125 141 62 FALSE 0.20
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 908 320 TMB overall -0.70 -2.36 0.89 1541.45 1.00 1526 829 241 79 FALSE 0.42
uterine cancer RAS_12-61 KMT2D Any mutation 138 252 TMB overall -0.56 -2.70 1.53 1197.15 1.00 297 96 210 42 FALSE 0.23
colorectal cancer RAS_12-61 TSC2 Any mutation 341 42 TMB quintile 5 -0.51 -1.13 0.14 1514.97 1.00 268 323 24 18 TRUE 0.96
colorectal cancer RAS_12-61 TSC2 Any mutation 39 56 TMB quintile 6 -0.23 -0.95 0.49 1591.51 1.00 72 26 43 13 TRUE 0.27
colorectal cancer RAS_12-61 TSC2 Any mutation 380 98 TMB overall -0.35 -2.56 1.85 1248.30 1.00 340 349 67 31 TRUE 0.13
colorectal cancer RAS_12-61 APC Any mutation 29 78 TMB quintile 2 -0.78 -1.51 -0.11 1573.07 1.00 49 19 68 10 TRUE 1.59
colorectal cancer RAS_12-61 APC Any mutation 226 428 TMB quintile 3 -0.41 -0.75 -0.04 1504.12 1.00 84 74 276 152 TRUE 1.62
colorectal cancer RAS_12-61 APC Any mutation 534 966 TMB quintile 4 0.15 -0.20 0.47 1474.87 1.00 83 69 501 465 TRUE 0.43
colorectal cancer RAS_12-61 APC Any mutation 561 822 TMB quintile 5 0.87 0.54 1.21 1113.28 1.00 93 58 319 503 TRUE 6.37
colorectal cancer RAS_12-61 APC Any mutation 76 225 TMB quintile 6 0.14 -0.40 0.73 1294.73 1.00 36 11 160 65 TRUE 0.20
melanoma RAS_12-61 APC Any mutation 160 67 TMB quintile 5 -0.49 -1.05 0.06 1477.39 1.00 203 140 47 20 TRUE 1.07
melanoma RAS_12-61 APC Any mutation 9 50 TMB quintile 6 0.19 -1.05 1.60 1543.49 1.00 35 3 44 6 TRUE 0.11
non-small cell lung cancer RAS_12-61 APC Any mutation 159 20 TMB quintile 3 -0.34 -1.19 0.47 1542.85 1.00 452 154 15 5 TRUE 0.38
non-small cell lung cancer RAS_12-61 APC Any mutation 267 31 TMB quintile 4 -0.94 -1.86 -0.24 1490.31 1.00 468 263 27 4 TRUE 1.64
non-small cell lung cancer RAS_12-61 APC Any mutation 477 101 TMB quintile 5 -0.13 -0.56 0.28 1393.18 1.00 691 440 64 37 TRUE 0.27
uterine cancer RAS_12-61 APC Any mutation 71 35 TMB quintile 5 -0.14 -0.96 0.61 1404.99 1.00 174 62 26 9 TRUE 0.13
uterine cancer RAS_12-61 APC Any mutation 16 84 TMB quintile 6 -0.81 -1.83 0.27 1400.57 1.00 24 7 75 9 TRUE 0.87
colorectal cancer RAS_12-61 APC Any mutation 1426 2519 TMB overall 0.00 -0.59 0.61 1471.61 1.00 345 231 1324 1195 TRUE 0.01
melanoma RAS_12-61 APC Any mutation 169 117 TMB overall -0.15 -2.47 2.32 1420.95 1.00 238 143 91 26 TRUE 0.05
non-small cell lung cancer RAS_12-61 APC Any mutation 903 152 TMB overall -0.47 -1.34 0.35 1481.36 1.00 1611 857 106 46 TRUE 0.54
uterine cancer RAS_12-61 APC Any mutation 87 119 TMB overall -0.43 -2.95 2.16 1539.88 1.00 198 69 101 18 TRUE 0.12
colorectal cancer RAS_12-61 ERBB2 Any mutation 375 17 TMB quintile 4 -0.37 -1.30 0.49 1460.96 1.00 406 368 10 7 TRUE 0.38
colorectal cancer RAS_12-61 ERBB2 Any mutation 338 33 TMB quintile 5 -0.46 -1.14 0.20 1507.32 1.00 269 324 19 14 TRUE 0.74
colorectal cancer RAS_12-61 ERBB2 Any mutation 38 42 TMB quintile 6 0.18 -0.56 0.96 1099.23 1.00 82 26 30 12 TRUE 0.19
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 83 14 TMB quintile 2 -2.02 -3.47 -0.85 1471.06 1.00 344 83 14 0 TRUE 2.65
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 159 27 TMB quintile 3 -1.45 -2.46 -0.41 1415.37 1.00 444 155 23 4 TRUE 2.23
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 267 32 TMB quintile 4 -2.32 -3.82 -1.32 1530.93 1.00 465 267 32 0 TRUE 3.62
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 474 40 TMB quintile 5 -1.73 -2.60 -0.97 1477.48 1.00 717 469 35 5 TRUE 4.48
colorectal cancer RAS_12-61 ERBB2 Any mutation 751 92 TMB overall -0.22 -1.66 1.22 1251.65 1.00 757 718 59 33 TRUE 0.12
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 983 113 TMB overall -1.87 -2.83 -1.00 1308.27 1.00 1970 974 104 9 TRUE 4.10
uterine cancer RAS_12-61 JAK1 Any mutation 75 88 TMB quintile 5 0.11 -0.44 0.67 1493.22 1.00 148 51 64 24 TRUE 0.16
uterine cancer RAS_12-61 JAK1 Any mutation 14 52 TMB quintile 6 1.00 -0.12 2.44 1464.95 1.00 26 2 40 12 TRUE 0.88
uterine cancer RAS_12-61 JAK1 Any mutation 89 140 TMB overall 0.51 -1.45 2.79 1484.74 1.00 174 53 104 36 TRUE 0.20
colorectal cancer RAS_12-61 ARID2 Any mutation 375 12 TMB quintile 4 -0.38 -1.44 0.71 1479.65 1.00 409 370 7 5 FALSE 0.31
colorectal cancer RAS_12-61 ARID2 Any mutation 339 31 TMB quintile 5 -0.14 -0.81 0.59 1170.03 1.00 274 323 15 16 FALSE 0.16
colorectal cancer RAS_12-61 ARID2 Any mutation 38 66 TMB quintile 6 -0.32 -1.02 0.44 1324.80 1.00 64 24 52 14 FALSE 0.42
melanoma RAS_12-61 ARID2 Any mutation 167 83 TMB quintile 5 0.04 -0.44 0.49 1397.45 1.00 200 133 49 34 FALSE 0.05
melanoma RAS_12-61 ARID2 Any mutation 10 53 TMB quintile 6 0.14 -1.13 1.40 1339.08 1.00 43 4 47 6 FALSE 0.08
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 159 19 TMB quintile 3 -0.71 -1.75 0.15 1459.06 1.00 450 157 17 2 FALSE 0.84
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 267 35 TMB quintile 4 -0.09 -0.73 0.56 1352.43 1.00 475 254 22 13 FALSE 0.10
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 475 111 TMB quintile 5 -0.31 -0.72 0.09 1276.89 1.00 683 440 76 35 FALSE 0.84
colorectal cancer RAS_12-61 ARID2 Any mutation 752 109 TMB overall -0.27 -2.10 1.69 1515.79 1.00 747 717 74 35 FALSE 0.11
melanoma RAS_12-61 ARID2 Any mutation 177 136 TMB overall 0.09 -2.42 2.43 1426.08 1.00 243 137 96 40 FALSE 0.03
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 901 165 TMB overall -0.37 -1.26 0.42 1563.05 1.00 1608 851 115 50 FALSE 0.42
colorectal cancer RAS_12-61 MTOR Any mutation 375 19 TMB quintile 4 0.91 0.02 1.93 1439.80 1.00 411 361 5 14 TRUE 1.21
colorectal cancer RAS_12-61 MTOR Any mutation 339 40 TMB quintile 5 0.03 -0.58 0.66 1484.92 1.00 270 317 18 22 TRUE 0.04
colorectal cancer RAS_12-61 MTOR Any mutation 43 70 TMB quintile 6 -0.16 -0.85 0.54 1456.75 1.00 66 26 53 17 TRUE 0.19
non-small cell lung cancer RAS_12-61 MTOR Any mutation 159 14 TMB quintile 3 -0.38 -1.46 0.46 1495.33 1.00 455 157 12 2 TRUE 0.38
non-small cell lung cancer RAS_12-61 MTOR Any mutation 268 21 TMB quintile 4 0.07 -0.65 0.79 1592.13 1.00 483 259 12 9 TRUE 0.07
non-small cell lung cancer RAS_12-61 MTOR Any mutation 476 70 TMB quintile 5 -0.05 -0.53 0.41 1372.90 1.00 705 450 44 26 TRUE 0.07
colorectal cancer RAS_12-61 MTOR Any mutation 757 129 TMB overall 0.25 -1.53 2.16 1263.93 1.00 747 704 76 53 TRUE 0.10
non-small cell lung cancer RAS_12-61 MTOR Any mutation 903 105 TMB overall -0.12 -0.94 0.64 1591.92 1.00 1643 866 68 37 TRUE 0.12
colorectal cancer RAS_12-61 NOTCH1 Any mutation 339 48 TMB quintile 5 -1.23 -1.89 -0.62 1553.89 1.00 256 326 35 13 TRUE 3.67
colorectal cancer RAS_12-61 NOTCH1 Any mutation 53 112 TMB quintile 6 0.52 -0.15 1.22 1337.08 1.00 52 15 74 38 TRUE 0.89
non-small cell lung cancer RAS_12-61 NOTCH1 Any mutation 267 15 TMB quintile 4 -0.57 -1.61 0.47 1338.20 1.00 484 263 11 4 TRUE 0.56
non-small cell lung cancer RAS_12-61 NOTCH1 Any mutation 475 97 TMB quintile 5 -0.57 -1.03 -0.12 1408.62 1.00 683 449 71 26 TRUE 1.87
colorectal cancer RAS_12-61 NOTCH1 Any mutation 392 160 TMB overall -0.31 -2.77 2.28 1465.31 1.00 308 341 109 51 TRUE 0.09
non-small cell lung cancer RAS_12-61 NOTCH1 Any mutation 742 112 TMB overall -0.54 -2.19 1.19 1346.33 1.00 1167 712 82 30 TRUE 0.28
colorectal cancer RAS_12-61 SETD2 Any mutation 192 11 TMB quintile 3 -1.74 -3.55 -0.33 1519.96 1.00 286 191 10 1 FALSE 1.45
colorectal cancer RAS_12-61 SETD2 Any mutation 339 31 TMB quintile 5 -1.30 -2.12 -0.55 1563.21 1.00 267 331 23 8 FALSE 2.93
colorectal cancer RAS_12-61 SETD2 Any mutation 43 64 TMB quintile 6 -0.24 -0.98 0.46 1529.46 1.00 68 27 48 16 FALSE 0.30
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 83 14 TMB quintile 2 -1.01 -2.57 0.08 1569.37 1.00 344 83 14 0 FALSE 0.84
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 160 22 TMB quintile 3 -0.88 -2.14 0.01 1725.55 1.00 452 158 20 2 FALSE 1.00
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 268 59 TMB quintile 4 -0.26 -0.82 0.26 1523.05 1.00 462 250 41 18 FALSE 0.46
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 482 110 TMB quintile 5 0.09 -0.30 0.47 1468.88 1.00 693 436 64 46 FALSE 0.18
colorectal cancer RAS_12-61 SETD2 Any mutation 574 106 TMB overall -1.03 -2.74 0.82 1443.95 1.00 621 549 81 25 FALSE 0.60
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 993 205 TMB overall -0.51 -1.44 0.24 1477.44 1.00 1951 927 139 66 FALSE 0.65
non-small cell lung cancer RAS_12-61 PBRM1 Any mutation 269 21 TMB quintile 4 0.24 -0.58 1.15 1437.62 1.00 485 259 11 10 TRUE 0.23
non-small cell lung cancer RAS_12-61 PBRM1 Any mutation 474 79 TMB quintile 5 -0.51 -1.05 -0.04 1580.56 1.00 700 453 58 21 TRUE 1.30
non-small cell lung cancer RAS_12-61 PBRM1 Any mutation 743 100 TMB overall -0.15 -1.68 1.45 1473.87 1.00 1185 712 69 31 TRUE 0.07
colorectal cancer RAS_12-61 EPHA3 Any mutation 376 17 TMB quintile 4 -0.14 -1.05 0.77 1560.21 1.00 407 368 9 8 FALSE 0.12
colorectal cancer RAS_12-61 EPHA3 Any mutation 338 41 TMB quintile 5 -0.01 -0.62 0.61 1589.14 1.00 270 316 19 22 FALSE 0.01
colorectal cancer RAS_12-61 EPHA3 Any mutation 40 44 TMB quintile 6 0.06 -0.71 0.84 1526.42 1.00 79 28 32 12 FALSE 0.06
melanoma RAS_12-61 EPHA3 Any mutation 164 57 TMB quintile 5 0.79 0.26 1.38 1384.78 1.00 218 131 24 33 FALSE 2.26
melanoma RAS_12-61 EPHA3 Any mutation 8 45 TMB quintile 6 0.36 -0.95 1.73 1548.73 1.00 35 3 40 5 FALSE 0.22
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 159 15 TMB quintile 3 0.54 -0.44 1.47 1340.26 1.00 458 153 9 6 FALSE 0.57
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 267 28 TMB quintile 4 0.58 -0.19 1.34 1498.87 1.00 481 253 14 14 FALSE 0.89
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 481 182 TMB quintile 5 0.05 -0.27 0.38 1416.68 1.00 650 409 110 72 FALSE 0.11
colorectal cancer RAS_12-61 EPHA3 Any mutation 754 102 TMB overall -0.02 -1.64 1.52 1583.66 1.00 756 712 60 42 FALSE 0.01
melanoma RAS_12-61 EPHA3 Any mutation 172 102 TMB overall 0.50 -2.10 3.08 1476.51 1.00 253 134 64 38 FALSE 0.15
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 908 237 TMB overall 0.39 -1.23 2.22 1484.21 1.00 1597 815 144 93 FALSE 0.19
melanoma RAS_12-61 KDR Any mutation 160 64 TMB quintile 5 -0.16 -0.68 0.37 1358.11 1.00 200 136 40 24 TRUE 0.25
melanoma RAS_12-61 KDR Any mutation 11 62 TMB quintile 6 -0.21 -1.35 1.07 1517.79 1.00 27 4 55 7 TRUE 0.13
non-small cell lung cancer RAS_12-61 KDR Any mutation 267 21 TMB quintile 4 0.32 -0.52 1.18 1310.15 1.00 484 257 11 10 TRUE 0.34
non-small cell lung cancer RAS_12-61 KDR Any mutation 477 109 TMB quintile 5 -0.24 -0.67 0.14 1482.68 1.00 678 441 73 36 TRUE 0.59
melanoma RAS_12-61 KDR Any mutation 171 126 TMB overall -0.21 -2.68 2.32 1571.35 1.00 227 140 95 31 TRUE 0.06
non-small cell lung cancer RAS_12-61 KDR Any mutation 744 130 TMB overall 0.03 -1.77 1.94 1638.93 1.00 1162 698 84 46 TRUE 0.01
colorectal cancer RAS_12-61 PTCH1 Any mutation 339 35 TMB quintile 5 -0.88 -1.56 -0.16 1558.77 1.00 266 327 23 12 TRUE 1.85
colorectal cancer RAS_12-61 PTCH1 Any mutation 46 99 TMB quintile 6 -0.16 -0.81 0.48 1301.68 1.00 53 21 74 25 TRUE 0.20
colorectal cancer RAS_12-61 PTCH1 Any mutation 385 134 TMB overall -0.52 -3.17 1.91 1620.20 1.00 319 348 97 37 TRUE 0.17
colorectal cancer RAS_12-61 TET1 Any mutation 320 26 TMB quintile 5 -0.68 -1.49 0.07 1375.88 1.00 255 310 16 10 FALSE 1.10
colorectal cancer RAS_12-61 TET1 Any mutation 44 67 TMB quintile 6 0.19 -0.47 0.88 1430.54 1.00 71 24 47 20 FALSE 0.24
non-small cell lung cancer RAS_12-61 TET1 Any mutation 267 16 TMB quintile 4 -0.67 -1.85 0.48 1513.58 1.00 480 263 12 4 FALSE 0.57
non-small cell lung cancer RAS_12-61 TET1 Any mutation 476 89 TMB quintile 5 -0.16 -0.63 0.28 1437.27 1.00 694 444 57 32 FALSE 0.31
colorectal cancer RAS_12-61 TET1 Any mutation 364 93 TMB overall -0.27 -2.73 2.12 1448.67 1.00 326 334 63 30 FALSE 0.09
non-small cell lung cancer RAS_12-61 TET1 Any mutation 744 120 TMB overall -0.99 -3.58 1.39 1512.04 1.00 1178 708 84 36 FALSE 0.37
uterine cancer RAS_12-61 FGFR2 Any mutation 48 23 TMB quintile 4 -1.39 -2.63 -0.20 1515.68 1.00 162 45 20 3 TRUE 1.58
uterine cancer RAS_12-61 FGFR2 Any mutation 70 52 TMB quintile 5 -1.89 -2.98 -1.00 1300.89 1.00 149 67 49 3 TRUE 3.65
uterine cancer RAS_12-61 FGFR2 Any mutation 10 18 TMB quintile 6 -2.00 -3.85 -0.64 1382.46 1.00 38 10 18 0 TRUE 1.84
uterine cancer RAS_12-61 FGFR2 Any mutation 128 93 TMB overall -1.75 -3.09 -0.65 1455.53 1.00 349 122 87 6 TRUE 2.32
non-small cell lung cancer RAS_12-61 TBX3 Any mutation 267 11 TMB quintile 4 -0.16 -1.35 1.00 1569.09 1.00 488 263 7 4 FALSE 0.10
non-small cell lung cancer RAS_12-61 TBX3 Any mutation 474 108 TMB quintile 5 -0.33 -0.73 0.07 1570.77 1.00 683 440 74 34 FALSE 0.94
non-small cell lung cancer RAS_12-61 TBX3 Any mutation 741 119 TMB overall -0.26 -2.27 1.63 1560.57 1.00 1171 703 81 38 FALSE 0.10
colorectal cancer RAS_12-61 SMAD3 Any mutation 192 12 TMB quintile 3 0.04 -0.91 0.94 1485.42 1.00 288 187 7 5 TRUE 0.04
colorectal cancer RAS_12-61 SMAD3 Any mutation 378 27 TMB quintile 4 0.14 -0.53 0.81 1500.23 1.00 405 364 13 14 TRUE 0.16
colorectal cancer RAS_12-61 SMAD3 Any mutation 345 44 TMB quintile 5 0.71 0.13 1.34 1232.44 1.00 276 313 12 32 TRUE 1.62
colorectal cancer RAS_12-61 SMAD3 Any mutation 38 23 TMB quintile 6 0.13 -0.78 0.97 1491.87 1.00 89 32 17 6 TRUE 0.11
colorectal cancer RAS_12-61 SMAD3 Any mutation 953 106 TMB overall 0.26 -0.58 1.11 1482.90 1.00 1058 896 49 57 TRUE 0.26
melanoma RAS_12-61 NTRK3 Any mutation 164 58 TMB quintile 5 -0.16 -0.70 0.43 1482.55 1.00 205 142 36 22 FALSE 0.23
melanoma RAS_12-61 NTRK3 Any mutation 9 42 TMB quintile 6 -0.39 -1.66 0.79 1377.48 1.00 35 5 38 4 FALSE 0.27
non-small cell lung cancer RAS_12-61 NTRK3 Any mutation 269 31 TMB quintile 4 1.04 0.39 1.74 1532.30 1.00 484 250 12 19 FALSE 2.47
non-small cell lung cancer RAS_12-61 NTRK3 Any mutation 478 144 TMB quintile 5 0.11 -0.25 0.47 1601.39 1.00 673 419 85 59 FALSE 0.25
melanoma RAS_12-61 NTRK3 Any mutation 173 100 TMB overall -0.27 -2.38 1.89 1253.32 1.00 240 147 74 26 FALSE 0.10
non-small cell lung cancer RAS_12-61 NTRK3 Any mutation 749 195 TMB overall 0.65 -1.76 3.32 1499.63 1.00 1164 669 115 80 FALSE 0.22
colorectal cancer RAS_12-61 GRIN2A Any mutation 375 30 TMB quintile 4 -0.53 -1.26 0.16 1429.75 1.00 397 364 19 11 FALSE 0.82
colorectal cancer RAS_12-61 GRIN2A Any mutation 339 42 TMB quintile 5 -0.59 -1.20 0.04 1350.42 1.00 263 322 25 17 FALSE 1.19
colorectal cancer RAS_12-61 GRIN2A Any mutation 38 59 TMB quintile 6 -0.38 -1.16 0.36 1507.37 1.00 70 26 47 12 FALSE 0.51
melanoma RAS_12-61 GRIN2A Any mutation 171 166 TMB quintile 5 -0.45 -0.83 -0.06 1598.11 1.00 156 117 112 54 FALSE 1.56
melanoma RAS_12-61 GRIN2A Any mutation 16 124 TMB quintile 6 0.48 -0.98 2.54 1456.49 1.00 17 1 109 15 FALSE 0.22
non-small cell lung cancer RAS_12-61 GRIN2A Any mutation 159 17 TMB quintile 3 0.56 -0.32 1.45 1279.02 1.00 458 151 9 8 FALSE 0.68
non-small cell lung cancer RAS_12-61 GRIN2A Any mutation 267 39 TMB quintile 4 0.25 -0.37 0.86 1466.30 1.00 473 251 23 16 FALSE 0.37
non-small cell lung cancer RAS_12-61 GRIN2A Any mutation 478 124 TMB quintile 5 -0.16 -0.55 0.21 1421.77 1.00 672 436 82 42 FALSE 0.38
colorectal cancer RAS_12-61 GRIN2A Any mutation 752 131 TMB overall -0.48 -1.86 0.94 1552.88 1.00 730 712 91 40 FALSE 0.31
melanoma RAS_12-61 GRIN2A Any mutation 187 290 TMB overall -0.03 -2.66 2.90 1453.13 1.00 173 118 221 69 FALSE 0.01
non-small cell lung cancer RAS_12-61 GRIN2A Any mutation 904 180 TMB overall 0.22 -0.71 1.32 1351.52 1.00 1603 838 114 66 FALSE 0.18
uterine cancer RAS_12-61 CTCF Any mutation 48 12 TMB quintile 4 0.43 -0.77 1.56 1393.78 1.00 173 44 8 4 FALSE 0.33
uterine cancer RAS_12-61 CTCF Any mutation 72 103 TMB quintile 5 0.14 -0.40 0.66 1419.07 1.00 123 43 74 29 FALSE 0.22
uterine cancer RAS_12-61 CTCF Any mutation 12 48 TMB quintile 6 0.55 -0.62 1.82 1463.86 1.00 24 3 39 9 FALSE 0.42
uterine cancer RAS_12-61 CTCF Any mutation 132 163 TMB overall 0.39 -1.25 2.19 1452.99 1.00 320 90 121 42 FALSE 0.19
non-small cell lung cancer RAS_12-61 STK11 Any mutation 83 12 TMB quintile 2 1.67 0.75 2.69 1374.88 1.00 354 75 4 8 TRUE 3.08
non-small cell lung cancer RAS_12-61 STK11 Any mutation 161 78 TMB quintile 3 1.60 1.12 2.11 1567.43 1.00 434 116 33 45 TRUE 9.59
non-small cell lung cancer RAS_12-61 STK11 Any mutation 270 161 TMB quintile 4 1.47 1.13 1.82 1521.33 1.00 435 169 60 101 TRUE 15.65
non-small cell lung cancer RAS_12-61 STK11 Any mutation 478 283 TMB quintile 5 0.31 0.03 0.60 1433.19 1.00 599 355 160 123 TRUE 1.46
non-small cell lung cancer RAS_12-61 STK11 Any mutation 992 534 TMB overall 1.25 0.20 2.29 1364.53 1.00 1822 715 257 277 TRUE 1.83
colorectal cancer RAS_12-61 ASXL1 Any mutation 375 15 TMB quintile 4 0.08 -0.90 1.04 1427.72 1.00 409 367 7 8 TRUE 0.06
colorectal cancer RAS_12-61 ASXL1 Any mutation 338 30 TMB quintile 5 -0.19 -0.90 0.53 1472.67 1.00 274 323 15 15 TRUE 0.22
colorectal cancer RAS_12-61 ASXL1 Any mutation 40 57 TMB quintile 6 -0.29 -1.04 0.44 1549.96 1.00 67 27 44 13 TRUE 0.35
colorectal cancer RAS_12-61 ASXL1 Any mutation 753 102 TMB overall -0.14 -1.93 1.46 1460.43 1.00 750 717 66 36 TRUE 0.06
colorectal cancer RAS_12-61 EP300 Any mutation 338 39 TMB quintile 5 -1.15 -1.90 -0.48 1274.29 1.00 262 327 28 11 TRUE 2.95
colorectal cancer RAS_12-61 EP300 Any mutation 44 72 TMB quintile 6 0.16 -0.56 0.86 1372.06 1.00 69 23 51 21 TRUE 0.18
non-small cell lung cancer RAS_12-61 EP300 Any mutation 475 77 TMB quintile 5 -0.42 -0.95 0.05 1239.11 1.00 700 452 54 23 TRUE 1.05
uterine cancer RAS_12-61 EP300 Any mutation 71 39 TMB quintile 5 0.18 -0.59 0.90 1559.42 1.00 168 59 27 12 TRUE 0.20
uterine cancer RAS_12-61 EP300 Any mutation 14 53 TMB quintile 6 0.10 -0.97 1.15 1499.22 1.00 27 5 44 9 TRUE 0.07
colorectal cancer RAS_12-61 EP300 Any mutation 382 111 TMB overall -0.47 -2.92 2.14 1048.62 1.00 331 350 79 32 TRUE 0.15
non-small cell lung cancer RAS_12-61 EP300 Any mutation 475 77 TMB overall -0.37 -4.64 3.84 1365.66 1.00 700 452 54 23 TRUE 0.08
uterine cancer RAS_12-61 EP300 Any mutation 85 92 TMB overall 0.14 -2.09 2.34 1364.63 1.00 195 64 71 21 TRUE 0.04
colorectal cancer RAS_12-61 ERBB4 Any mutation 375 22 TMB quintile 4 0.03 -0.76 0.84 1459.39 1.00 406 364 11 11 TRUE 0.02
colorectal cancer RAS_12-61 ERBB4 Any mutation 339 45 TMB quintile 5 -0.18 -0.76 0.36 1483.44 1.00 266 317 23 22 TRUE 0.28
colorectal cancer RAS_12-61 ERBB4 Any mutation 44 61 TMB quintile 6 0.73 0.07 1.41 1453.12 1.00 76 21 38 23 TRUE 1.47
melanoma RAS_12-61 ERBB4 Any mutation 163 92 TMB quintile 5 -0.33 -0.82 0.12 1500.91 1.00 186 132 61 31 TRUE 0.75
melanoma RAS_12-61 ERBB4 Any mutation 19 89 TMB quintile 6 1.21 -0.31 3.20 1498.68 1.00 19 1 71 18 TRUE 0.77
non-small cell lung cancer RAS_12-61 ERBB4 Any mutation 267 25 TMB quintile 4 -0.29 -1.19 0.53 1360.80 1.00 478 259 17 8 TRUE 0.29
non-small cell lung cancer RAS_12-61 ERBB4 Any mutation 479 148 TMB quintile 5 -0.60 -1.00 -0.21 1326.57 1.00 661 439 108 40 TRUE 2.56
colorectal cancer RAS_12-61 ERBB4 Any mutation 758 128 TMB overall 0.20 -1.36 1.74 1579.96 1.00 748 702 72 56 TRUE 0.10
melanoma RAS_12-61 ERBB4 Any mutation 182 181 TMB overall 0.41 -2.35 3.73 1524.12 1.00 205 133 132 49 TRUE 0.11
non-small cell lung cancer RAS_12-61 ERBB4 Any mutation 747 185 TMB overall -0.90 -3.38 1.16 1491.76 1.00 1147 699 137 48 TRUE 0.37
colorectal cancer RAS_12-61 MED12 Any mutation 376 18 TMB quintile 4 -0.02 -0.88 0.85 1686.37 1.00 407 367 9 9 TRUE 0.01
colorectal cancer RAS_12-61 MED12 Any mutation 338 28 TMB quintile 5 -0.06 -0.78 0.68 1453.73 1.00 277 323 13 15 TRUE 0.07
colorectal cancer RAS_12-61 MED12 Any mutation 41 59 TMB quintile 6 -0.08 -0.81 0.63 1492.80 1.00 69 26 44 15 TRUE 0.08
non-small cell lung cancer RAS_12-61 MED12 Any mutation 159 23 TMB quintile 3 -0.21 -0.96 0.54 1688.04 1.00 450 153 17 6 TRUE 0.24
non-small cell lung cancer RAS_12-61 MED12 Any mutation 267 32 TMB quintile 4 -0.32 -0.96 0.27 1410.64 1.00 472 258 23 9 TRUE 0.51
non-small cell lung cancer RAS_12-61 MED12 Any mutation 478 101 TMB quintile 5 -0.20 -0.62 0.17 1391.62 1.00 687 444 67 34 TRUE 0.50
uterine cancer RAS_12-61 MED12 Any mutation 14 13 TMB quintile 2 -1.64 -4.07 0.17 1375.81 1.00 118 14 13 0 TRUE 0.87
uterine cancer RAS_12-61 MED12 Any mutation 26 16 TMB quintile 3 -0.43 -1.93 0.95 1466.49 1.00 201 24 14 2 TRUE 0.25
uterine cancer RAS_12-61 MED12 Any mutation 48 20 TMB quintile 4 -1.06 -2.48 0.13 1491.50 1.00 163 46 18 2 TRUE 0.95
uterine cancer RAS_12-61 MED12 Any mutation 70 31 TMB quintile 5 -0.21 -1.09 0.62 1559.25 1.00 173 62 23 8 TRUE 0.21
uterine cancer RAS_12-61 MED12 Any mutation 11 58 TMB quintile 6 -1.83 -3.35 -0.57 1464.75 1.00 24 9 56 2 TRUE 2.02
colorectal cancer RAS_12-61 MED12 Any mutation 755 105 TMB overall -0.06 -1.65 1.64 1265.30 1.00 753 716 66 39 TRUE 0.03
non-small cell lung cancer RAS_12-61 MED12 Any mutation 904 156 TMB overall -0.25 -0.95 0.44 1544.18 1.00 1609 855 107 49 TRUE 0.31
uterine cancer RAS_12-61 MED12 Any mutation 169 138 TMB overall -0.99 -2.28 0.22 1386.77 1.00 679 155 124 14 TRUE 0.92
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 83 29 TMB quintile 2 0.32 -0.39 0.94 1490.14 1.00 335 77 23 6 FALSE 0.46
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 159 46 TMB quintile 3 0.42 -0.11 0.93 1487.31 1.00 437 144 31 15 FALSE 0.92
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 268 90 TMB quintile 4 0.80 0.39 1.23 1571.45 1.00 453 220 42 48 FALSE 3.87
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 483 200 TMB quintile 5 0.77 0.50 1.06 1376.12 1.00 667 374 91 109 FALSE 6.81
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 993 365 TMB overall 0.58 0.06 1.07 1529.08 1.00 1892 815 187 178 FALSE 1.53
colorectal cancer RAS_12-61 NF1 Any mutation 375 13 TMB quintile 4 -1.58 -3.05 -0.40 1395.01 1.00 406 373 11 2 TRUE 1.62
colorectal cancer RAS_12-61 NF1 Any mutation 339 34 TMB quintile 5 -0.46 -1.13 0.21 1462.02 1.00 269 324 19 15 TRUE 0.75
colorectal cancer RAS_12-61 NF1 Any mutation 41 86 TMB quintile 6 -0.42 -1.09 0.27 1450.52 1.00 65 24 69 17 TRUE 0.65
melanoma RAS_12-61 NF1 Any mutation 17 13 TMB quintile 3 0.27 -1.30 1.62 1290.08 1.00 84 14 10 3 TRUE 0.15
melanoma RAS_12-61 NF1 Any mutation 22 11 TMB quintile 4 -2.32 -5.96 -0.14 1468.91 1.00 74 22 11 0 TRUE 0.93
melanoma RAS_12-61 NF1 Any mutation 165 162 TMB quintile 5 -1.06 -1.51 -0.63 1481.60 1.00 156 129 126 36 TRUE 5.47
melanoma RAS_12-61 NF1 Any mutation 15 100 TMB quintile 6 1.11 -0.71 3.88 1442.55 1.00 12 0 85 15 TRUE 0.47
non-small cell lung cancer RAS_12-61 NF1 Any mutation 159 25 TMB quintile 3 -0.80 -1.74 0.12 1423.96 1.00 447 155 21 4 TRUE 1.06
non-small cell lung cancer RAS_12-61 NF1 Any mutation 267 59 TMB quintile 4 -1.18 -1.91 -0.55 1497.50 1.00 452 259 51 8 TRUE 3.15
non-small cell lung cancer RAS_12-61 NF1 Any mutation 481 216 TMB quintile 5 -0.55 -0.86 -0.24 1654.09 1.00 623 420 155 61 TRUE 3.13
uterine cancer RAS_12-61 NF1 Any mutation 70 38 TMB quintile 5 -0.80 -1.76 0.09 1361.96 1.00 167 64 32 6 TRUE 1.04
uterine cancer RAS_12-61 NF1 Any mutation 13 73 TMB quintile 6 -0.88 -2.01 0.28 1234.41 1.00 23 6 66 7 TRUE 0.90
colorectal cancer RAS_12-61 NF1 Any mutation 755 133 TMB overall -0.80 -2.72 1.17 1511.49 1.00 740 721 99 34 TRUE 0.40
melanoma RAS_12-61 NF1 Any mutation 219 286 TMB overall -0.49 -2.62 1.53 1351.61 1.00 326 165 232 54 TRUE 0.20
non-small cell lung cancer RAS_12-61 NF1 Any mutation 907 300 TMB overall -0.84 -1.89 0.10 1371.19 1.00 1522 834 227 73 TRUE 1.02
uterine cancer RAS_12-61 NF1 Any mutation 83 111 TMB overall -0.83 -3.22 1.42 1441.86 1.00 190 70 98 13 TRUE 0.31
melanoma RAS_12-61 FLT1 Any mutation 161 60 TMB quintile 5 -0.16 -0.76 0.43 1597.47 1.00 202 139 38 22 FALSE 0.22
melanoma RAS_12-61 FLT1 Any mutation 14 56 TMB quintile 6 1.85 0.42 3.74 1549.23 1.00 34 1 43 13 FALSE 1.47
non-small cell lung cancer RAS_12-61 FLT1 Any mutation 267 21 TMB quintile 4 0.90 0.07 1.84 1691.91 1.00 488 254 8 13 FALSE 1.27
non-small cell lung cancer RAS_12-61 FLT1 Any mutation 477 99 TMB quintile 5 -0.42 -0.88 0.01 1306.17 1.00 686 448 70 29 FALSE 1.19
melanoma RAS_12-61 FLT1 Any mutation 175 116 TMB overall 0.75 -2.38 3.75 1526.67 1.00 236 140 81 35 FALSE 0.20
non-small cell lung cancer RAS_12-61 FLT1 Any mutation 744 120 TMB overall 0.23 -1.91 2.44 1524.95 1.00 1174 702 78 42 FALSE 0.08
uterine cancer RAS_12-61 RASA1 Any mutation 70 25 TMB quintile 5 -0.91 -2.20 0.18 1494.60 1.00 173 66 21 4 FALSE 0.88
uterine cancer RAS_12-61 RASA1 Any mutation 10 70 TMB quintile 6 -2.48 -4.25 -1.01 1366.89 1.00 21 8 68 2 FALSE 2.65
uterine cancer RAS_12-61 RASA1 Any mutation 80 95 TMB overall -1.55 -4.39 1.54 1573.71 1.00 194 74 89 6 FALSE 0.54
colorectal cancer RAS_12-61 EPHA5 Any mutation 375 18 TMB quintile 4 -0.29 -1.24 0.62 1469.44 1.00 406 367 10 8 FALSE 0.27
colorectal cancer RAS_12-61 EPHA5 Any mutation 339 52 TMB quintile 5 -0.52 -1.12 0.04 1579.25 1.00 260 317 30 22 FALSE 1.11
colorectal cancer RAS_12-61 EPHA5 Any mutation 40 66 TMB quintile 6 -0.56 -1.32 0.20 1480.43 1.00 70 28 54 12 FALSE 0.83
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 267 48 TMB quintile 4 0.44 -0.14 1.02 1496.51 1.00 470 245 26 22 FALSE 0.86
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 479 191 TMB quintile 5 0.09 -0.20 0.40 1427.95 1.00 649 402 114 77 FALSE 0.25
colorectal cancer RAS_12-61 EPHA5 Any mutation 754 136 TMB overall -0.44 -2.05 1.18 1206.56 1.00 736 712 94 42 FALSE 0.23
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 747 250 TMB overall 0.25 -1.45 2.31 1519.12 1.00 1129 647 150 100 FALSE 0.10
colorectal cancer RAS_12-61 AR Any mutation 375 21 TMB quintile 4 -0.85 -1.82 -0.01 1364.49 1.01 401 369 15 6 TRUE 1.18
colorectal cancer RAS_12-61 AR Any mutation 339 34 TMB quintile 5 -0.68 -1.43 0.00 1529.77 1.00 268 326 21 13 TRUE 1.24
colorectal cancer RAS_12-61 AR Any mutation 41 55 TMB quintile 6 0.23 -0.48 0.93 1292.03 1.00 73 24 38 17 TRUE 0.29
non-small cell lung cancer RAS_12-61 AR Any mutation 267 16 TMB quintile 4 0.11 -0.82 1.03 1473.02 1.00 486 260 9 7 TRUE 0.09
non-small cell lung cancer RAS_12-61 AR Any mutation 477 77 TMB quintile 5 -0.26 -0.76 0.22 1539.07 1.00 702 452 52 25 TRUE 0.53
colorectal cancer RAS_12-61 AR Any mutation 755 110 TMB overall -0.45 -2.12 1.03 1182.09 1.00 742 719 74 36 TRUE 0.26
non-small cell lung cancer RAS_12-61 AR Any mutation 744 93 TMB overall -0.07 -1.47 1.65 1492.66 1.00 1188 712 61 32 TRUE 0.03
colorectal cancer RAS_12-61 ROS1 Any mutation 375 14 TMB quintile 4 -1.25 -2.48 -0.13 1621.67 1.00 405 372 11 3 TRUE 1.46
colorectal cancer RAS_12-61 ROS1 Any mutation 338 24 TMB quintile 5 -0.94 -1.76 -0.14 1478.89 1.00 272 330 16 8 TRUE 1.58
colorectal cancer RAS_12-61 ROS1 Any mutation 43 61 TMB quintile 6 -0.32 -1.09 0.40 1560.71 1.00 74 29 47 14 TRUE 0.40
melanoma RAS_12-61 ROS1 Any mutation 165 139 TMB quintile 5 -0.30 -0.71 0.09 1593.23 1.00 169 118 92 47 TRUE 0.81
melanoma RAS_12-61 ROS1 Any mutation 15 103 TMB quintile 6 0.85 -0.57 2.74 1524.17 1.00 22 1 89 14 TRUE 0.48
non-small cell lung cancer RAS_12-61 ROS1 Any mutation 267 13 TMB quintile 4 -1.72 -3.61 -0.34 1653.70 1.00 483 266 12 1 TRUE 1.46
non-small cell lung cancer RAS_12-61 ROS1 Any mutation 475 80 TMB quintile 5 -0.87 -1.41 -0.37 1569.44 1.00 691 457 62 18 TRUE 3.01
colorectal cancer RAS_12-61 ROS1 Any mutation 756 99 TMB overall -0.83 -2.42 1.04 1342.92 1.00 751 731 74 25 TRUE 0.49
melanoma RAS_12-61 ROS1 Any mutation 180 242 TMB overall 0.27 -2.45 3.12 1539.36 1.00 191 119 181 61 TRUE 0.08
non-small cell lung cancer RAS_12-61 ROS1 Any mutation 742 93 TMB overall -1.25 -3.15 0.58 1397.87 1.00 1174 723 74 19 TRUE 0.77
colorectal cancer RAS_12-61 PIK3CG Any mutation 375 16 TMB quintile 4 -0.78 -1.77 0.18 1552.54 1.00 405 370 11 5 FALSE 0.96
colorectal cancer RAS_12-61 PIK3CG Any mutation 338 38 TMB quintile 5 -0.43 -1.13 0.23 1349.76 1.00 267 321 21 17 FALSE 0.70
colorectal cancer RAS_12-61 PIK3CG Any mutation 41 45 TMB quintile 6 -0.34 -1.11 0.44 1513.44 1.00 80 31 35 10 FALSE 0.41
melanoma RAS_12-61 PIK3CG Any mutation 159 43 TMB quintile 5 -0.34 -1.01 0.28 1438.42 1.00 211 145 29 14 FALSE 0.52
melanoma RAS_12-61 PIK3CG Any mutation 12 56 TMB quintile 6 1.09 -0.19 2.70 1527.68 1.00 35 2 46 10 FALSE 0.84
non-small cell lung cancer RAS_12-61 PIK3CG Any mutation 267 16 TMB quintile 4 0.45 -0.55 1.44 1389.46 1.00 487 259 8 8 FALSE 0.43
non-small cell lung cancer RAS_12-61 PIK3CG Any mutation 478 150 TMB quintile 5 -0.17 -0.54 0.16 1434.99 1.00 665 426 98 52 FALSE 0.47
colorectal cancer RAS_12-61 PIK3CG Any mutation 754 99 TMB overall -0.51 -1.87 0.97 1561.57 1.00 752 722 67 32 FALSE 0.33
melanoma RAS_12-61 PIK3CG Any mutation 171 99 TMB overall 0.34 -2.36 3.11 1442.64 1.00 246 147 75 24 FALSE 0.09
non-small cell lung cancer RAS_12-61 PIK3CG Any mutation 745 166 TMB overall 0.14 -1.84 2.10 1338.06 1.00 1152 685 106 60 FALSE 0.05
non-small cell lung cancer RAS_12-61 EGFR Any mutation 83 200 TMB quintile 2 -4.93 -7.08 -3.40 1110.49 1.00 180 83 200 0 TRUE 6.31
non-small cell lung cancer RAS_12-61 EGFR Any mutation 159 287 TMB quintile 3 -4.79 -6.53 -3.56 1462.67 1.00 238 158 286 1 TRUE 9.66
non-small cell lung cancer RAS_12-61 EGFR Any mutation 267 256 TMB quintile 4 -4.02 -5.09 -3.18 1508.70 1.00 307 263 252 4 TRUE 15.41
non-small cell lung cancer RAS_12-61 EGFR Any mutation 475 175 TMB quintile 5 -1.94 -2.50 -1.42 1434.31 1.00 632 456 156 19 TRUE 12.76
non-small cell lung cancer RAS_12-61 EGFR Any mutation 984 918 TMB overall -3.87 -5.40 -2.77 1407.28 1.00 1357 960 894 24 TRUE 8.05
colorectal cancer RAS_12-61 ARID1B Any mutation 375 13 TMB quintile 4 -0.94 -2.08 0.20 1646.85 1.00 408 371 9 4 TRUE 0.97
colorectal cancer RAS_12-61 ARID1B Any mutation 339 46 TMB quintile 5 -1.18 -1.83 -0.53 1508.99 1.00 257 326 33 13 TRUE 3.32
colorectal cancer RAS_12-61 ARID1B Any mutation 37 79 TMB quintile 6 -0.94 -1.76 -0.22 1370.36 1.00 56 25 67 12 TRUE 1.78
non-small cell lung cancer RAS_12-61 ARID1B Any mutation 159 11 TMB quintile 3 -0.65 -1.89 0.43 1525.34 1.00 458 157 9 2 TRUE 0.59
non-small cell lung cancer RAS_12-61 ARID1B Any mutation 267 16 TMB quintile 4 -1.01 -2.23 -0.06 1428.74 1.00 482 265 14 2 TRUE 1.14
non-small cell lung cancer RAS_12-61 ARID1B Any mutation 476 77 TMB quintile 5 -0.25 -0.73 0.20 1426.79 1.00 701 450 51 26 TRUE 0.54
uterine cancer RAS_12-61 ARID1B Any mutation 74 59 TMB quintile 5 0.03 -0.60 0.65 1661.97 1.00 155 57 42 17 TRUE 0.03
uterine cancer RAS_12-61 ARID1B Any mutation 10 48 TMB quintile 6 -0.48 -1.71 0.71 1567.82 1.00 25 5 43 5 TRUE 0.37
colorectal cancer RAS_12-61 ARID1B Any mutation 751 138 TMB overall -0.99 -2.69 0.88 1400.45 1.00 721 722 109 29 TRUE 0.56
non-small cell lung cancer RAS_12-61 ARID1B Any mutation 902 104 TMB overall -0.65 -1.75 0.30 1497.41 1.00 1641 872 74 30 TRUE 0.66
uterine cancer RAS_12-61 ARID1B Any mutation 84 107 TMB overall -0.19 -2.40 1.98 1494.08 1.00 180 62 85 22 TRUE 0.07
non-small cell lung cancer RAS_12-61 MET Any mutation 83 21 TMB quintile 2 -0.91 -1.97 0.01 1454.42 1.00 340 81 19 2 TRUE 1.16
non-small cell lung cancer RAS_12-61 MET Any mutation 159 30 TMB quintile 3 -1.00 -1.99 -0.18 1495.63 1.00 446 156 27 3 TRUE 1.55
non-small cell lung cancer RAS_12-61 MET Any mutation 267 34 TMB quintile 4 -1.42 -2.51 -0.60 1577.32 1.00 469 265 32 2 TRUE 2.35
non-small cell lung cancer RAS_12-61 MET Any mutation 474 47 TMB quintile 5 -0.22 -0.80 0.38 1438.91 1.00 723 455 28 19 TRUE 0.33
non-small cell lung cancer RAS_12-61 MET Any mutation 983 132 TMB overall -0.89 -1.73 -0.19 1488.74 1.00 1978 957 106 26 TRUE 1.68
colorectal cancer RAS_12-61 BRAF Any mutation 192 27 TMB quintile 3 -1.97 -3.13 -0.94 1371.04 1.00 271 189 24 3 TRUE 3.37
colorectal cancer RAS_12-61 BRAF Any mutation 375 60 TMB quintile 4 -2.10 -2.83 -1.43 1469.01 1.00 363 368 53 7 TRUE 8.17
colorectal cancer RAS_12-61 BRAF Any mutation 339 104 TMB quintile 5 -2.88 -3.58 -2.25 1528.28 1.00 194 331 96 8 TRUE 15.97
colorectal cancer RAS_12-61 BRAF Any mutation 39 59 TMB quintile 6 -1.41 -2.28 -0.57 1286.69 1.00 61 31 51 8 TRUE 3.03
melanoma RAS_12-61 BRAF Any mutation 18 16 TMB quintile 2 -2.67 -4.80 -0.80 1436.02 1.00 88 18 16 0 TRUE 2.23
melanoma RAS_12-61 BRAF Any mutation 17 27 TMB quintile 3 -2.93 -5.12 -1.28 1540.85 1.00 66 17 27 0 TRUE 2.66
melanoma RAS_12-61 BRAF Any mutation 22 53 TMB quintile 4 -2.31 -3.53 -1.24 1430.94 1.00 34 19 50 3 TRUE 4.13
melanoma RAS_12-61 BRAF Any mutation 163 170 TMB quintile 5 -2.20 -2.70 -1.71 1449.26 1.00 104 141 148 22 TRUE 17.25
melanoma RAS_12-61 BRAF Any mutation 8 17 TMB quintile 6 -2.05 -3.90 -0.36 1135.83 1.00 46 7 16 1 TRUE 1.63
non-small cell lung cancer RAS_12-61 BRAF Any mutation 83 11 TMB quintile 2 -1.76 -3.80 -0.34 1601.44 1.00 347 83 11 0 TRUE 1.40
non-small cell lung cancer RAS_12-61 BRAF Any mutation 159 13 TMB quintile 3 -1.89 -3.88 -0.59 1386.24 1.00 454 159 13 0 TRUE 1.56
non-small cell lung cancer RAS_12-61 BRAF Any mutation 267 46 TMB quintile 4 -1.21 -2.04 -0.50 1571.32 1.00 457 260 39 7 TRUE 2.73
non-small cell lung cancer RAS_12-61 BRAF Any mutation 474 101 TMB quintile 5 -0.66 -1.11 -0.22 1563.92 1.00 677 447 74 27 TRUE 2.42
colorectal cancer RAS_12-61 BRAF Any mutation 945 250 TMB overall -2.08 -3.04 -1.08 1522.33 1.00 889 919 224 26 TRUE 4.57
melanoma RAS_12-61 BRAF Any mutation 228 283 TMB overall -2.42 -3.72 -1.20 1547.39 1.00 338 202 257 26 TRUE 3.94
non-small cell lung cancer RAS_12-61 BRAF Any mutation 983 171 TMB overall -1.37 -2.53 -0.36 1390.36 1.00 1935 949 137 34 TRUE 1.84
colorectal cancer RAS_12-61 B2M Any mutation 325 50 TMB quintile 5 -0.96 -1.54 -0.33 1404.13 1.00 249 309 34 16 FALSE 2.68
colorectal cancer RAS_12-61 B2M Any mutation 48 79 TMB quintile 6 0.36 -0.30 1.00 1463.87 1.00 67 22 53 26 FALSE 0.55
colorectal cancer RAS_12-61 B2M Any mutation 373 129 TMB overall -0.30 -2.58 1.88 1593.68 1.00 316 331 87 42 FALSE 0.10
colorectal cancer RAS_12-61 CARD11 Any mutation 375 28 TMB quintile 4 0.15 -0.54 0.84 1496.11 1.00 403 360 13 15 FALSE 0.17
colorectal cancer RAS_12-61 CARD11 Any mutation 339 43 TMB quintile 5 -0.39 -1.01 0.22 1485.47 1.00 264 320 24 19 FALSE 0.69
colorectal cancer RAS_12-61 CARD11 Any mutation 41 52 TMB quintile 6 0.42 -0.27 1.14 1414.43 1.00 77 24 35 17 FALSE 0.61
melanoma RAS_12-61 CARD11 Any mutation 161 63 TMB quintile 5 -0.52 -1.10 0.05 1459.98 1.00 201 142 44 19 FALSE 1.11
melanoma RAS_12-61 CARD11 Any mutation 8 45 TMB quintile 6 -0.42 -1.69 0.87 1467.29 1.00 32 4 41 4 FALSE 0.27
non-small cell lung cancer RAS_12-61 CARD11 Any mutation 267 18 TMB quintile 4 0.01 -0.87 0.85 1489.21 1.00 484 260 11 7 FALSE 0.01
non-small cell lung cancer RAS_12-61 CARD11 Any mutation 477 97 TMB quintile 5 0.00 -0.43 0.41 1562.89 1.00 692 440 60 37 FALSE 0.01
colorectal cancer RAS_12-61 CARD11 Any mutation 755 123 TMB overall 0.07 -1.38 1.49 1494.49 1.00 744 704 72 51 FALSE 0.03
melanoma RAS_12-61 CARD11 Any mutation 169 108 TMB overall -0.44 -2.68 1.91 1397.62 1.00 233 146 85 23 FALSE 0.15
non-small cell lung cancer RAS_12-61 CARD11 Any mutation 744 115 TMB overall 0.00 -1.41 1.56 1324.77 1.00 1176 700 71 44 FALSE 0.00
non-small cell lung cancer RAS_12-61 INPP4B Any mutation 267 17 TMB quintile 4 0.41 -0.40 1.21 1599.14 1.00 486 259 9 8 FALSE 0.50
non-small cell lung cancer RAS_12-61 INPP4B Any mutation 478 87 TMB quintile 5 0.64 0.22 1.09 1602.23 1.00 713 432 41 46 FALSE 2.46
non-small cell lung cancer RAS_12-61 INPP4B Any mutation 745 104 TMB overall 0.55 -0.65 1.89 1422.54 1.00 1199 691 50 54 FALSE 0.42
non-small cell lung cancer RAS_12-61 NFE2L2 Any mutation 267 31 TMB quintile 4 -0.86 -1.60 -0.19 1463.27 1.00 476 261 25 6 FALSE 1.81
non-small cell lung cancer RAS_12-61 NFE2L2 Any mutation 476 83 TMB quintile 5 -0.80 -1.30 -0.30 1530.60 1.00 690 457 64 19 FALSE 2.79
non-small cell lung cancer RAS_12-61 NFE2L2 Any mutation 743 114 TMB overall -0.84 -1.73 -0.02 1496.36 1.00 1166 718 89 25 FALSE 1.24
colorectal cancer RAS_12-61 SOX9 Any mutation 192 17 TMB quintile 3 -0.04 -0.87 0.80 1464.70 1.00 285 185 10 7 FALSE 0.03
colorectal cancer RAS_12-61 SOX9 Any mutation 379 85 TMB quintile 4 0.28 -0.14 0.72 1472.84 1.00 377 333 39 46 FALSE 0.70
colorectal cancer RAS_12-61 SOX9 Any mutation 345 107 TMB quintile 5 0.04 -0.35 0.48 1253.11 1.00 244 287 49 58 FALSE 0.08
colorectal cancer RAS_12-61 SOX9 Any mutation 40 50 TMB quintile 6 0.59 -0.07 1.27 1409.80 1.00 78 22 32 18 FALSE 1.05
colorectal cancer RAS_12-61 SOX9 Any mutation 956 259 TMB overall 0.22 -0.68 1.10 1579.24 1.00 984 827 130 129 FALSE 0.21
colorectal cancer RAS_12-61 SMAD2 Any mutation 375 29 TMB quintile 4 0.07 -0.58 0.71 1506.27 1.00 402 361 15 14 TRUE 0.08
colorectal cancer RAS_12-61 SMAD2 Any mutation 342 53 TMB quintile 5 0.53 0.01 1.05 1269.83 1.00 273 307 18 35 TRUE 1.30
colorectal cancer RAS_12-61 SMAD2 Any mutation 38 16 TMB quintile 6 0.50 -0.43 1.42 1500.09 1.00 97 32 10 6 TRUE 0.57
colorectal cancer RAS_12-61 SMAD2 Any mutation 755 98 TMB overall 0.35 -0.57 1.34 1450.22 1.00 772 700 43 55 TRUE 0.35
melanoma RAS_12-61 TP63 Any mutation 158 95 TMB quintile 5 -0.05 -0.54 0.41 1379.15 1.00 175 120 57 38 FALSE 0.08
melanoma RAS_12-61 TP63 Any mutation 8 69 TMB quintile 6 -0.93 -2.42 0.49 1653.56 1.00 14 3 64 5 FALSE 0.67
melanoma RAS_12-61 TP63 Any mutation 166 164 TMB overall -0.48 -3.22 2.25 1433.34 1.00 189 123 121 43 FALSE 0.14
non-small cell lung cancer RAS_12-61 GLI1 Any mutation 250 16 TMB quintile 4 0.35 -0.45 1.22 1446.86 1.00 424 242 8 8 FALSE 0.38
non-small cell lung cancer RAS_12-61 GLI1 Any mutation 434 77 TMB quintile 5 0.27 -0.18 0.70 1631.72 1.00 630 400 43 34 FALSE 0.61
non-small cell lung cancer RAS_12-61 GLI1 Any mutation 684 93 TMB overall 0.32 -1.03 1.74 1346.75 1.00 1054 642 51 42 FALSE 0.19
colorectal cancer RAS_12-61 ZFHX3 Any mutation 342 14 TMB quintile 4 0.23 -0.72 1.25 1579.04 1.00 372 334 6 8 FALSE 0.18
colorectal cancer RAS_12-61 ZFHX3 Any mutation 314 63 TMB quintile 5 -0.40 -0.89 0.11 1630.41 1.00 236 286 35 28 FALSE 0.90
colorectal cancer RAS_12-61 ZFHX3 Any mutation 46 143 TMB quintile 6 -0.12 -0.83 0.60 1480.36 1.00 37 13 110 33 FALSE 0.13
melanoma RAS_12-61 ZFHX3 Any mutation 156 62 TMB quintile 5 -0.15 -0.71 0.41 1249.30 1.00 196 133 39 23 FALSE 0.21
melanoma RAS_12-61 ZFHX3 Any mutation 7 78 TMB quintile 6 -0.03 -1.47 1.50 1526.26 1.00 34 2 73 5 FALSE 0.01
non-small cell lung cancer RAS_12-61 ZFHX3 Any mutation 147 13 TMB quintile 3 -0.95 -2.41 0.08 1577.24 1.00 411 146 12 1 FALSE 0.87
non-small cell lung cancer RAS_12-61 ZFHX3 Any mutation 249 30 TMB quintile 4 -0.39 -1.10 0.29 1372.07 1.00 409 240 21 9 FALSE 0.54
non-small cell lung cancer RAS_12-61 ZFHX3 Any mutation 434 112 TMB quintile 5 -0.24 -0.66 0.15 1481.59 1.00 601 396 74 38 FALSE 0.60
uterine cancer RAS_12-61 ZFHX3 Any mutation 44 13 TMB quintile 4 -0.16 -1.55 1.10 1491.90 1.00 151 41 10 3 FALSE 0.09
uterine cancer RAS_12-61 ZFHX3 Any mutation 72 105 TMB quintile 5 0.00 -0.58 0.57 1505.04 1.00 123 44 77 28 FALSE 0.00
uterine cancer RAS_12-61 ZFHX3 Any mutation 16 92 TMB quintile 6 -0.78 -1.85 0.27 1526.79 1.00 19 6 82 10 FALSE 0.82
colorectal cancer RAS_12-61 ZFHX3 Any mutation 702 220 TMB overall -0.07 -2.08 2.36 1302.61 1.00 645 633 151 69 FALSE 0.02
melanoma RAS_12-61 ZFHX3 Any mutation 163 140 TMB overall -0.13 -2.76 2.77 1629.15 1.00 230 135 112 28 FALSE 0.03
non-small cell lung cancer RAS_12-61 ZFHX3 Any mutation 830 155 TMB overall -0.52 -1.57 0.40 1517.77 1.00 1421 782 107 48 FALSE 0.50
uterine cancer RAS_12-61 ZFHX3 Any mutation 132 210 TMB overall -0.30 -2.11 1.46 1659.21 1.00 293 91 169 41 FALSE 0.13
colorectal cancer RAS_12-61 MGA Any mutation 342 15 TMB quintile 4 -0.96 -2.12 0.04 1551.67 1.00 368 338 11 4 FALSE 1.12
colorectal cancer RAS_12-61 MGA Any mutation 314 46 TMB quintile 5 -0.30 -0.94 0.28 1564.82 1.00 241 292 24 22 FALSE 0.50
colorectal cancer RAS_12-61 MGA Any mutation 39 58 TMB quintile 6 -0.11 -0.87 0.59 1483.72 1.00 64 24 43 15 FALSE 0.11
non-small cell lung cancer RAS_12-61 MGA Any mutation 147 14 TMB quintile 3 0.21 -0.70 1.12 1486.80 1.00 415 142 9 5 FALSE 0.19
non-small cell lung cancer RAS_12-61 MGA Any mutation 249 24 TMB quintile 4 0.12 -0.63 0.89 1543.55 1.00 416 239 14 10 FALSE 0.13
non-small cell lung cancer RAS_12-61 MGA Any mutation 437 140 TMB quintile 5 -0.02 -0.38 0.34 1494.56 1.00 596 384 87 53 FALSE 0.04
uterine cancer RAS_12-61 MGA Any mutation 66 24 TMB quintile 5 -0.40 -1.50 0.56 1514.40 1.00 166 61 19 5 FALSE 0.35
uterine cancer RAS_12-61 MGA Any mutation 16 82 TMB quintile 6 0.28 -0.99 1.66 1411.80 1.00 21 3 69 13 FALSE 0.17
colorectal cancer RAS_12-61 MGA Any mutation 695 119 TMB overall -0.43 -1.99 1.13 1596.72 1.00 673 654 78 41 FALSE 0.23
non-small cell lung cancer RAS_12-61 MGA Any mutation 833 178 TMB overall 0.10 -0.97 1.16 1520.38 1.00 1427 765 110 68 FALSE 0.07
uterine cancer RAS_12-61 MGA Any mutation 82 106 TMB overall -0.07 -2.99 2.82 1336.10 1.00 187 64 88 18 FALSE 0.02
colorectal cancer RAS_12-61 KMT2B Any mutation 178 54 TMB quintile 5 -0.15 -0.74 0.40 1310.33 1.00 129 151 27 27 FALSE 0.22
colorectal cancer RAS_12-61 KMT2B Any mutation 26 115 TMB quintile 6 1.49 0.02 3.49 1509.05 1.00 21 1 90 25 FALSE 1.02
uterine cancer RAS_12-61 KMT2B Any mutation 60 95 TMB quintile 5 0.18 -0.37 0.78 1495.75 1.00 95 32 67 28 FALSE 0.26
uterine cancer RAS_12-61 KMT2B Any mutation 11 67 TMB quintile 6 -0.28 -1.70 1.30 1477.73 1.00 8 2 58 9 FALSE 0.15
colorectal cancer RAS_12-61 KMT2B Any mutation 204 169 TMB overall 0.59 -2.91 3.93 1420.21 1.00 150 152 117 52 FALSE 0.14
uterine cancer RAS_12-61 KMT2B Any mutation 71 162 TMB overall 0.03 -2.26 2.55 1271.45 1.00 103 34 125 37 FALSE 0.01
colorectal cancer RAS_12-61 TCF7L2 Any mutation 178 35 TMB quintile 3 0.13 -0.51 0.79 1490.09 1.00 244 162 19 16 FALSE 0.16
colorectal cancer RAS_12-61 TCF7L2 Any mutation 346 79 TMB quintile 4 0.25 -0.22 0.71 1447.39 1.00 342 303 36 43 FALSE 0.56
colorectal cancer RAS_12-61 TCF7L2 Any mutation 319 108 TMB quintile 5 -0.01 -0.41 0.38 1384.87 1.00 218 261 50 58 FALSE 0.03
colorectal cancer RAS_12-61 TCF7L2 Any mutation 37 70 TMB quintile 6 0.04 -0.61 0.73 1400.15 1.00 55 19 52 18 FALSE 0.04
colorectal cancer RAS_12-61 TCF7L2 Any mutation 880 292 TMB overall 0.10 -0.83 0.95 1489.43 1.00 859 745 157 135 FALSE 0.08
colorectal cancer RAS_12-61 ANKRD11 Any mutation 334 11 TMB quintile 4 0.01 -1.11 1.16 1351.15 1.00 363 328 5 6 FALSE 0.00
colorectal cancer RAS_12-61 ANKRD11 Any mutation 295 43 TMB quintile 5 -1.58 -2.35 -0.90 1340.70 1.00 215 286 34 9 FALSE 4.37
colorectal cancer RAS_12-61 ANKRD11 Any mutation 41 86 TMB quintile 6 -0.14 -0.81 0.52 1655.89 1.00 55 20 65 21 FALSE 0.17
colorectal cancer RAS_12-61 ANKRD11 Any mutation 670 140 TMB overall -0.59 -2.57 1.48 1455.58 1.00 633 634 104 36 FALSE 0.24
colorectal cancer RAS_12-61 POLD1 Any mutation 315 20 TMB quintile 5 -0.26 -1.10 0.65 1564.38 1.00 256 305 10 10 TRUE 0.25
colorectal cancer RAS_12-61 POLD1 Any mutation 38 83 TMB quintile 6 -0.44 -1.18 0.31 1571.27 1.00 52 21 66 17 TRUE 0.61
colorectal cancer RAS_12-61 POLD1 Any mutation 353 103 TMB overall -0.31 -3.15 2.58 1589.17 1.00 308 326 76 27 TRUE 0.08
melanoma RAS_12-61 PREX2 Any mutation 98 89 TMB quintile 5 0.09 -0.44 0.63 1462.66 1.00 95 61 52 37 FALSE 0.14
melanoma RAS_12-61 PREX2 Any mutation 13 76 TMB quintile 6 0.56 -0.96 2.58 1639.67 1.00 12 1 64 12 FALSE 0.28
non-small cell lung cancer RAS_12-61 PREX2 Any mutation 140 14 TMB quintile 4 -0.33 -1.28 0.62 1251.99 1.00 210 135 9 5 FALSE 0.30
non-small cell lung cancer RAS_12-61 PREX2 Any mutation 243 84 TMB quintile 5 -0.37 -0.86 0.11 1576.93 1.00 327 217 58 26 FALSE 0.87
melanoma RAS_12-61 PREX2 Any mutation 111 165 TMB overall 0.30 -2.42 3.07 1625.16 1.00 107 62 116 49 FALSE 0.09
non-small cell lung cancer RAS_12-61 PREX2 Any mutation 383 98 TMB overall -0.34 -1.81 1.04 1464.17 1.00 537 352 67 31 FALSE 0.19
colorectal cancer RAS_12-61 AMER1 Any mutation 192 13 TMB quintile 3 0.96 0.05 1.97 1418.31 1.00 291 183 4 9 FALSE 1.28
colorectal cancer RAS_12-61 AMER1 Any mutation 375 38 TMB quintile 4 0.96 0.31 1.68 1451.94 1.00 407 348 11 27 FALSE 2.32
colorectal cancer RAS_12-61 AMER1 Any mutation 338 62 TMB quintile 5 0.68 0.15 1.22 1500.48 1.00 268 296 20 42 FALSE 1.85
colorectal cancer RAS_12-61 AMER1 Any mutation 43 55 TMB quintile 6 0.81 0.13 1.50 1424.06 1.00 76 22 34 21 FALSE 1.66
non-small cell lung cancer RAS_12-61 AMER1 Any mutation 267 18 TMB quintile 4 0.99 0.08 1.98 1376.01 1.00 488 256 7 11 FALSE 1.35
non-small cell lung cancer RAS_12-61 AMER1 Any mutation 479 107 TMB quintile 5 0.48 0.09 0.88 1574.24 1.00 701 426 54 53 FALSE 1.75
colorectal cancer RAS_12-61 AMER1 Any mutation 948 168 TMB overall 0.84 -0.24 1.98 1204.23 1.00 1042 849 69 99 FALSE 0.85
non-small cell lung cancer RAS_12-61 AMER1 Any mutation 747 142 TMB overall 0.62 -1.96 3.28 1439.04 1.00 1199 682 77 65 FALSE 0.20
melanoma RAS_12-61 EPHA7 Any mutation 157 89 TMB quintile 5 -0.05 -0.50 0.39 1358.74 1.00 184 122 54 35 FALSE 0.08
melanoma RAS_12-61 EPHA7 Any mutation 8 63 TMB quintile 6 -0.32 -1.68 1.12 1451.82 1.00 27 3 58 5 FALSE 0.18
non-small cell lung cancer RAS_12-61 EPHA7 Any mutation 249 14 TMB quintile 4 -0.25 -1.20 0.70 1362.66 1.00 420 244 9 5 FALSE 0.21
non-small cell lung cancer RAS_12-61 EPHA7 Any mutation 433 101 TMB quintile 5 -0.39 -0.84 0.03 1532.02 1.00 607 402 70 31 FALSE 1.09
melanoma RAS_12-61 EPHA7 Any mutation 165 152 TMB overall -0.20 -2.71 2.22 1018.53 1.00 211 125 112 40 FALSE 0.06
non-small cell lung cancer RAS_12-61 EPHA7 Any mutation 682 115 TMB overall -0.32 -2.05 1.61 1365.24 1.00 1027 646 79 36 FALSE 0.15
uterine cancer RAS_12-61 INPPL1 Any mutation 59 82 TMB quintile 5 0.24 -0.36 0.84 1570.22 1.00 93 33 56 26 FALSE 0.38
uterine cancer RAS_12-61 INPPL1 Any mutation 12 40 TMB quintile 6 0.08 -0.94 1.19 1550.23 1.00 16 4 32 8 FALSE 0.06
uterine cancer RAS_12-61 INPPL1 Any mutation 71 122 TMB overall 0.22 -1.21 1.78 1618.38 1.00 109 37 88 34 FALSE 0.11
colorectal cancer KRAS_12-61 SPEN Any mutation 341 11 TMB quintile 4 -0.47 -1.68 0.61 1383.80 1.00 443 337 7 4 FALSE 0.36
colorectal cancer KRAS_12-61 SPEN Any mutation 315 31 TMB quintile 5 -0.24 -0.94 0.50 1659.50 1.00 298 301 17 14 FALSE 0.29
colorectal cancer KRAS_12-61 SPEN Any mutation 36 107 TMB quintile 6 -0.75 -1.48 -0.06 1312.51 1.00 52 20 91 16 FALSE 1.41
non-small cell lung cancer KRAS_12-61 SPEN Any mutation 262 15 TMB quintile 4 -1.25 -2.63 -0.16 1389.51 1.00 487 260 13 2 FALSE 1.28
non-small cell lung cancer KRAS_12-61 SPEN Any mutation 456 87 TMB quintile 5 -0.79 -1.29 -0.31 1376.17 1.00 729 437 68 19 FALSE 2.58
uterine cancer KRAS_12-61 SPEN Any mutation 63 37 TMB quintile 5 0.70 -0.07 1.45 1431.48 1.00 178 49 23 14 FALSE 1.19
uterine cancer KRAS_12-61 SPEN Any mutation 10 77 TMB quintile 6 -0.95 -2.23 0.32 1509.82 1.00 24 5 72 5 FALSE 0.79
colorectal cancer KRAS_12-61 SPEN Any mutation 692 149 TMB overall -0.49 -2.61 1.67 1362.35 1.00 793 658 115 34 FALSE 0.19
non-small cell lung cancer KRAS_12-61 SPEN Any mutation 718 102 TMB overall -1.01 -2.69 0.60 1587.56 1.00 1216 697 81 21 FALSE 0.65
uterine cancer KRAS_12-61 SPEN Any mutation 73 114 TMB overall -0.09 -3.07 3.10 1451.64 1.00 202 54 95 19 FALSE 0.02
colorectal cancer KRAS_12-61 KMT2C Any mutation 333 12 TMB quintile 4 -0.23 -1.42 0.89 1486.42 1.00 433 328 7 5 FALSE 0.16
colorectal cancer KRAS_12-61 KMT2C Any mutation 296 61 TMB quintile 5 -0.54 -1.07 0.00 1388.37 1.00 262 273 38 23 FALSE 1.35
colorectal cancer KRAS_12-61 KMT2C Any mutation 43 116 TMB quintile 6 -0.44 -1.15 0.28 1419.46 1.00 52 20 93 23 FALSE 0.64
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 155 13 TMB quintile 3 -1.05 -2.64 0.09 1409.53 1.00 455 154 12 1 FALSE 0.90
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 262 36 TMB quintile 4 -0.30 -0.93 0.35 1495.16 1.00 474 251 25 11 FALSE 0.42
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 455 155 TMB quintile 5 -0.40 -0.76 -0.05 1362.25 1.00 665 410 110 45 FALSE 1.50
uterine cancer KRAS_12-61 KMT2C Any mutation 60 42 TMB quintile 5 -0.64 -1.62 0.21 1384.78 1.00 154 53 35 7 FALSE 0.79
uterine cancer KRAS_12-61 KMT2C Any mutation 10 91 TMB quintile 6 -1.08 -2.40 0.24 1523.66 1.00 18 4 85 6 FALSE 0.95
colorectal cancer KRAS_12-61 KMT2C Any mutation 672 189 TMB overall -0.38 -2.33 1.56 1392.80 1.00 747 621 138 51 FALSE 0.16
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 872 204 TMB overall -0.58 -1.81 0.53 1180.93 1.00 1594 815 147 57 FALSE 0.50
uterine cancer KRAS_12-61 KMT2C Any mutation 70 133 TMB overall -0.78 -3.38 1.78 1511.52 1.00 172 57 120 13 FALSE 0.26
cancer of unknown primary KRAS_12-61 TP53 Any mutation 29 39 TMB quintile 2 0.09 -0.71 0.93 1382.81 1.00 61 17 27 12 TRUE 0.09
cancer of unknown primary KRAS_12-61 TP53 Any mutation 36 74 TMB quintile 3 -0.07 -0.74 0.59 1377.89 1.00 54 17 55 19 TRUE 0.07
cancer of unknown primary KRAS_12-61 TP53 Any mutation 37 87 TMB quintile 4 -0.73 -1.44 -0.10 1418.97 1.00 39 21 71 16 TRUE 1.46
cancer of unknown primary KRAS_12-61 TP53 Any mutation 44 153 TMB quintile 5 -0.79 -1.43 -0.18 1621.22 1.00 37 19 128 25 TRUE 1.85
colorectal cancer KRAS_12-61 TP53 Any mutation 27 104 TMB quintile 2 -1.39 -2.17 -0.65 1429.48 1.00 21 13 90 14 TRUE 3.43
colorectal cancer KRAS_12-61 TP53 Any mutation 176 411 TMB quintile 3 -1.39 -1.86 -0.95 1479.35 1.00 29 56 291 120 TRUE 8.65
colorectal cancer KRAS_12-61 TP53 Any mutation 352 655 TMB quintile 4 -1.22 -1.56 -0.89 1366.41 1.00 58 117 420 235 TRUE 11.52
colorectal cancer KRAS_12-61 TP53 Any mutation 337 423 TMB quintile 5 -0.62 -0.93 -0.31 1598.88 1.00 101 148 234 189 TRUE 4.17
colorectal cancer KRAS_12-61 TP53 Any mutation 40 78 TMB quintile 6 -0.72 -1.39 -0.06 1504.12 1.00 67 25 63 15 TRUE 1.44
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 83 180 TMB quintile 2 -1.14 -1.70 -0.62 1568.84 1.00 199 64 161 19 TRUE 4.30
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 155 324 TMB quintile 3 -1.56 -1.96 -1.16 1531.26 1.00 197 118 287 37 TRUE 13.41
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 265 450 TMB quintile 4 -1.48 -1.78 -1.17 1138.62 1.00 162 176 361 89 TRUE 20.65
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 470 996 TMB quintile 5 -1.79 -2.06 -1.53 1507.02 1.00 108 224 750 246 TRUE 37.62
pancreatic cancer KRAS_12-61 TP53 Any mutation 277 216 TMB quintile 2 2.63 2.08 3.36 1276.87 1.00 62 68 7 209 TRUE 14.88
pancreatic cancer KRAS_12-61 TP53 Any mutation 455 392 TMB quintile 3 2.53 2.08 3.00 1441.98 1.00 52 82 19 373 TRUE 37.62
pancreatic cancer KRAS_12-61 TP53 Any mutation 241 206 TMB quintile 4 2.23 1.63 2.75 1262.21 1.00 27 51 16 190 TRUE 13.61
pancreatic cancer KRAS_12-61 TP53 Any mutation 38 34 TMB quintile 5 2.04 1.18 2.70 1154.40 1.00 11 11 7 27 TRUE 6.94
uterine cancer KRAS_12-61 TP53 Any mutation 13 77 TMB quintile 2 -1.19 -2.07 -0.38 1509.14 1.00 60 9 73 4 TRUE 2.27
uterine cancer KRAS_12-61 TP53 Any mutation 27 167 TMB quintile 3 -1.18 -1.82 -0.52 1333.73 1.00 68 16 156 11 TRUE 3.33
uterine cancer KRAS_12-61 TP53 Any mutation 44 132 TMB quintile 4 -1.37 -2.00 -0.73 1515.84 1.00 79 33 121 11 TRUE 4.46
uterine cancer KRAS_12-61 TP53 Any mutation 64 68 TMB quintile 5 -1.05 -1.74 -0.35 1362.39 1.00 148 55 59 9 TRUE 2.64
uterine cancer KRAS_12-61 TP53 Any mutation 8 39 TMB quintile 6 -1.07 -2.03 -0.06 1543.52 1.00 33 5 36 3 TRUE 1.47
cancer of unknown primary KRAS_12-61 TP53 Any mutation 149 378 TMB overall -0.45 -1.21 0.38 1392.60 1.00 193 75 304 74 TRUE 0.56
colorectal cancer KRAS_12-61 TP53 Any mutation 932 1671 TMB overall -1.08 -1.79 -0.34 1425.85 1.00 276 359 1098 573 TRUE 2.44
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 973 1950 TMB overall -1.48 -2.32 -0.57 1530.74 1.00 666 582 1559 391 TRUE 3.23
pancreatic cancer KRAS_12-61 TP53 Any mutation 1011 848 TMB overall 2.35 1.77 2.93 1261.82 1.00 152 212 49 799 TRUE 37.62
uterine cancer KRAS_12-61 TP53 Any mutation 156 483 TMB overall -1.16 -1.83 -0.53 1530.42 1.00 388 118 445 38 TRUE 3.27
colorectal cancer KRAS_12-61 ATRX Any mutation 341 19 TMB quintile 4 -0.61 -1.51 0.31 1540.09 1.00 437 335 13 6 TRUE 0.73
colorectal cancer KRAS_12-61 ATRX Any mutation 313 35 TMB quintile 5 -0.45 -1.14 0.22 1558.66 1.00 294 299 21 14 TRUE 0.71
colorectal cancer KRAS_12-61 ATRX Any mutation 39 59 TMB quintile 6 -0.22 -1.02 0.51 1444.87 1.00 75 26 46 13 TRUE 0.25
non-small cell lung cancer KRAS_12-61 ATRX Any mutation 262 32 TMB quintile 4 0.06 -0.61 0.70 1434.30 1.00 481 250 20 12 TRUE 0.07
non-small cell lung cancer KRAS_12-61 ATRX Any mutation 461 160 TMB quintile 5 0.19 -0.14 0.52 1091.53 1.00 693 396 95 65 TRUE 0.56
uterine cancer KRAS_12-61 ATRX Any mutation 13 11 TMB quintile 2 -2.09 -5.71 0.32 1611.39 1.00 121 13 11 0 TRUE 0.74
uterine cancer KRAS_12-61 ATRX Any mutation 26 14 TMB quintile 3 -2.28 -5.80 0.03 1335.32 1.00 201 26 14 0 TRUE 0.88
uterine cancer KRAS_12-61 ATRX Any mutation 62 19 TMB quintile 5 -0.44 -1.75 0.69 1424.87 1.00 187 58 15 4 TRUE 0.32
uterine cancer KRAS_12-61 ATRX Any mutation 9 112 TMB quintile 6 -0.82 -2.18 0.56 1542.28 1.00 25 3 106 6 TRUE 0.63
colorectal cancer KRAS_12-61 ATRX Any mutation 693 113 TMB overall -0.43 -1.91 1.07 1296.88 1.00 806 660 80 33 TRUE 0.25
non-small cell lung cancer KRAS_12-61 ATRX Any mutation 723 192 TMB overall 0.11 -1.23 1.37 1505.24 1.00 1174 646 115 77 TRUE 0.06
uterine cancer KRAS_12-61 ATRX Any mutation 110 156 TMB overall -1.34 -3.65 0.62 1466.64 1.00 534 100 146 10 TRUE 0.69
colorectal cancer KRAS_12-61 ATR Any mutation 314 35 TMB quintile 5 -0.38 -1.06 0.29 1384.79 1.00 293 299 20 15 FALSE 0.58
colorectal cancer KRAS_12-61 ATR Any mutation 38 65 TMB quintile 6 -1.02 -1.91 -0.22 1501.21 1.00 76 30 57 8 FALSE 1.73
non-small cell lung cancer KRAS_12-61 ATR Any mutation 155 12 TMB quintile 3 -0.44 -1.58 0.59 1570.57 1.00 461 153 10 2 FALSE 0.37
non-small cell lung cancer KRAS_12-61 ATR Any mutation 263 15 TMB quintile 4 -0.02 -0.94 0.92 1620.33 1.00 492 257 9 6 FALSE 0.01
non-small cell lung cancer KRAS_12-61 ATR Any mutation 455 93 TMB quintile 5 -0.20 -0.62 0.25 1573.66 1.00 707 425 63 30 FALSE 0.42
colorectal cancer KRAS_12-61 ATR Any mutation 352 100 TMB overall -0.69 -3.18 1.66 1541.26 1.00 369 329 77 23 FALSE 0.25
non-small cell lung cancer KRAS_12-61 ATR Any mutation 873 120 TMB overall -0.22 -1.23 0.86 1585.66 1.00 1660 835 82 38 FALSE 0.17
non-small cell lung cancer KRAS_12-61 PDGFRA Any mutation 262 16 TMB quintile 4 -0.32 -1.30 0.59 1457.59 1.00 489 257 11 5 TRUE 0.29
non-small cell lung cancer KRAS_12-61 PDGFRA Any mutation 456 115 TMB quintile 5 -0.28 -0.67 0.11 1484.33 1.00 695 420 79 36 TRUE 0.74
non-small cell lung cancer KRAS_12-61 PDGFRA Any mutation 718 131 TMB overall -0.28 -1.93 1.50 1605.59 1.00 1184 677 90 41 TRUE 0.13
colorectal cancer KRAS_12-61 FBXW7 Any mutation 175 22 TMB quintile 3 -0.75 -1.78 0.12 1262.43 1.00 295 171 18 4 TRUE 0.92
colorectal cancer KRAS_12-61 FBXW7 Any mutation 347 85 TMB quintile 4 0.20 -0.24 0.61 1348.62 1.00 411 306 44 41 TRUE 0.44
colorectal cancer KRAS_12-61 FBXW7 Any mutation 332 160 TMB quintile 5 0.48 0.14 0.82 1508.69 1.00 254 236 64 96 TRUE 2.15
colorectal cancer KRAS_12-61 FBXW7 Any mutation 34 65 TMB quintile 6 0.40 -0.29 1.11 1448.14 1.00 68 16 47 18 TRUE 0.57
uterine cancer KRAS_12-61 FBXW7 Any mutation 26 30 TMB quintile 3 -0.33 -1.62 0.76 1354.42 1.00 188 24 28 2 TRUE 0.24
uterine cancer KRAS_12-61 FBXW7 Any mutation 44 29 TMB quintile 4 0.28 -0.58 1.09 1671.61 1.00 163 37 22 7 TRUE 0.30
uterine cancer KRAS_12-61 FBXW7 Any mutation 62 30 TMB quintile 5 0.45 -0.32 1.22 1331.41 1.00 180 52 20 10 TRUE 0.59
uterine cancer KRAS_12-61 FBXW7 Any mutation 10 47 TMB quintile 6 0.66 -0.43 1.94 1332.64 1.00 27 2 39 8 TRUE 0.55
colorectal cancer KRAS_12-61 FBXW7 Any mutation 888 332 TMB overall 0.10 -0.90 1.12 1500.62 1.00 1028 729 173 159 TRUE 0.08
uterine cancer KRAS_12-61 FBXW7 Any mutation 142 136 TMB overall 0.25 -0.84 1.38 1226.45 1.00 558 115 109 27 TRUE 0.18
uterine cancer KRAS_12-61 NSD1 Any mutation 65 46 TMB quintile 5 -0.14 -0.94 0.59 1602.32 1.00 172 55 36 10 FALSE 0.15
uterine cancer KRAS_12-61 NSD1 Any mutation 14 69 TMB quintile 6 1.33 -0.09 3.28 1520.88 1.00 23 1 56 13 FALSE 0.90
uterine cancer KRAS_12-61 NSD1 Any mutation 79 115 TMB overall 0.48 -2.34 3.24 1424.45 1.00 195 56 92 23 FALSE 0.14
colorectal cancer KRAS_12-61 FLT4 Any mutation 341 20 TMB quintile 4 -0.49 -1.43 0.37 1506.06 1.00 437 334 13 7 TRUE 0.55
colorectal cancer KRAS_12-61 FLT4 Any mutation 314 40 TMB quintile 5 -0.78 -1.47 -0.11 1428.82 1.00 289 301 27 13 TRUE 1.56
colorectal cancer KRAS_12-61 FLT4 Any mutation 37 72 TMB quintile 6 -0.20 -0.94 0.50 1494.13 1.00 62 21 56 16 TRUE 0.23
non-small cell lung cancer KRAS_12-61 FLT4 Any mutation 262 14 TMB quintile 4 0.33 -0.60 1.32 1475.90 1.00 493 255 7 7 TRUE 0.29
non-small cell lung cancer KRAS_12-61 FLT4 Any mutation 456 74 TMB quintile 5 -0.16 -0.70 0.30 1577.48 1.00 721 432 50 24 TRUE 0.29
colorectal cancer KRAS_12-61 FLT4 Any mutation 692 132 TMB overall -0.48 -2.13 1.15 1431.37 1.00 788 656 96 36 TRUE 0.26
non-small cell lung cancer KRAS_12-61 FLT4 Any mutation 718 88 TMB overall 0.07 -1.44 1.76 1364.35 1.00 1214 687 57 31 TRUE 0.03
colorectal cancer KRAS_12-61 PTPRD Any mutation 313 29 TMB quintile 5 -0.74 -1.54 0.01 1380.51 1.00 296 303 19 10 FALSE 1.23
colorectal cancer KRAS_12-61 PTPRD Any mutation 35 61 TMB quintile 6 -0.74 -1.59 0.10 1379.48 1.00 73 26 52 9 FALSE 1.08
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 155 16 TMB quintile 3 -0.12 -1.28 0.96 1405.60 1.00 460 151 12 4 FALSE 0.08
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 263 53 TMB quintile 4 0.52 -0.02 1.06 1611.42 1.00 472 238 28 25 FALSE 1.23
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 474 298 TMB quintile 5 -0.01 -0.27 0.25 1441.03 1.00 612 364 188 110 FALSE 0.03
colorectal cancer KRAS_12-61 PTPRD Any mutation 348 90 TMB overall -0.67 -2.90 1.60 1478.47 1.00 369 329 71 19 FALSE 0.25
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 893 384 TMB overall 0.08 -1.48 1.84 1523.86 1.00 1551 753 244 140 FALSE 0.03
non-small cell lung cancer KRAS_12-61 PIK3C2G Any mutation 262 12 TMB quintile 4 -0.28 -1.36 0.79 1427.76 1.00 489 258 8 4 FALSE 0.21
non-small cell lung cancer KRAS_12-61 PIK3C2G Any mutation 454 103 TMB quintile 5 -0.37 -0.82 0.06 1279.02 1.00 698 424 73 30 FALSE 0.96
non-small cell lung cancer KRAS_12-61 PIK3C2G Any mutation 716 115 TMB overall -0.32 -2.08 1.51 1540.19 1.00 1187 682 81 34 FALSE 0.15
colorectal cancer KRAS_12-61 CREBBP Any mutation 341 17 TMB quintile 4 -1.01 -2.13 0.02 1284.12 1.00 437 337 13 4 TRUE 1.16
colorectal cancer KRAS_12-61 CREBBP Any mutation 316 49 TMB quintile 5 -0.09 -0.71 0.48 1251.98 1.00 292 292 25 24 TRUE 0.12
colorectal cancer KRAS_12-61 CREBBP Any mutation 41 116 TMB quintile 6 -0.81 -1.55 -0.11 1280.26 1.00 43 21 96 20 TRUE 1.51
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 155 11 TMB quintile 3 -0.14 -1.34 1.00 1430.46 1.00 463 152 8 3 TRUE 0.09
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 262 12 TMB quintile 4 -0.24 -1.29 0.78 1383.91 1.00 492 258 8 4 TRUE 0.19
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 454 106 TMB quintile 5 -0.25 -0.67 0.19 1593.51 1.00 705 421 73 33 TRUE 0.59
colorectal cancer KRAS_12-61 CREBBP Any mutation 698 182 TMB overall -0.60 -2.47 1.42 1393.72 1.00 772 650 134 48 TRUE 0.28
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 871 129 TMB overall -0.22 -1.35 0.88 1526.39 1.00 1660 831 89 40 TRUE 0.16
colorectal cancer KRAS_12-61 AXIN2 Any mutation 341 20 TMB quintile 4 0.50 -0.36 1.40 1475.20 1.00 442 329 8 12 TRUE 0.59
colorectal cancer KRAS_12-61 AXIN2 Any mutation 313 27 TMB quintile 5 -0.54 -1.31 0.21 1522.31 1.00 297 303 17 10 TRUE 0.78
colorectal cancer KRAS_12-61 AXIN2 Any mutation 35 63 TMB quintile 6 -0.44 -1.26 0.34 1531.07 1.00 71 24 52 11 TRUE 0.57
colorectal cancer KRAS_12-61 AXIN2 Any mutation 689 110 TMB overall -0.14 -1.84 1.59 1487.71 1.00 810 656 77 33 TRUE 0.06
non-small cell lung cancer KRAS_12-61 DOT1L Any mutation 262 24 TMB quintile 4 -0.38 -1.20 0.23 64.31 1.04 484 256 18 6 FALSE 0.51
non-small cell lung cancer KRAS_12-61 DOT1L Any mutation 455 75 TMB quintile 5 -0.21 -0.74 0.21 65.44 1.04 718 431 51 24 FALSE 0.40
non-small cell lung cancer KRAS_12-61 DOT1L Any mutation 717 99 TMB overall -0.31 -1.38 0.53 385.66 1.01 1202 687 69 30 FALSE 0.29
colorectal cancer KRAS_12-61 PTPRS Any mutation 171 17 TMB quintile 3 -0.65 -1.79 0.36 1640.63 1.00 298 167 13 4 FALSE 0.64
colorectal cancer KRAS_12-61 PTPRS Any mutation 333 34 TMB quintile 4 0.21 -0.47 0.88 1543.57 1.00 423 316 17 17 FALSE 0.26
colorectal cancer KRAS_12-61 PTPRS Any mutation 300 74 TMB quintile 5 -0.18 -0.65 0.29 1521.99 1.00 260 266 40 34 FALSE 0.35
colorectal cancer KRAS_12-61 PTPRS Any mutation 41 128 TMB quintile 6 -0.07 -0.78 0.68 1574.37 1.00 37 12 99 29 FALSE 0.07
colorectal cancer KRAS_12-61 PTPRS Any mutation 845 253 TMB overall -0.19 -1.60 1.23 1545.64 1.00 1018 761 169 84 FALSE 0.10
colorectal cancer KRAS_12-61 SMARCA4 Any mutation 341 16 TMB quintile 4 -0.92 -2.06 0.08 1397.44 1.00 438 337 12 4 FALSE 1.01
colorectal cancer KRAS_12-61 SMARCA4 Any mutation 314 47 TMB quintile 5 -0.52 -1.13 0.08 1592.87 1.00 287 296 29 18 FALSE 1.06
colorectal cancer KRAS_12-61 SMARCA4 Any mutation 40 100 TMB quintile 6 -0.37 -1.06 0.35 1378.50 1.00 55 20 80 20 FALSE 0.50
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 156 35 TMB quintile 3 0.59 -0.08 1.27 1398.27 1.00 454 141 20 15 FALSE 1.05
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 263 67 TMB quintile 4 0.03 -0.49 0.52 1437.98 1.00 459 240 44 23 FALSE 0.04
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 459 194 TMB quintile 5 -0.11 -0.44 0.18 1535.32 1.00 647 393 128 66 FALSE 0.32
uterine cancer KRAS_12-61 SMARCA4 Any mutation 64 39 TMB quintile 5 -0.38 -1.30 0.46 1388.17 1.00 176 57 32 7 FALSE 0.41
uterine cancer KRAS_12-61 SMARCA4 Any mutation 12 52 TMB quintile 6 0.50 -0.72 1.76 1426.05 1.00 28 3 43 9 FALSE 0.37
colorectal cancer KRAS_12-61 SMARCA4 Any mutation 695 163 TMB overall -0.54 -2.26 1.35 1559.71 1.00 780 653 121 42 FALSE 0.26
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 878 296 TMB overall 0.17 -0.59 0.97 1488.34 1.00 1560 774 192 104 FALSE 0.18
uterine cancer KRAS_12-61 SMARCA4 Any mutation 76 91 TMB overall 0.04 -2.19 2.59 1603.64 1.00 204 60 75 16 FALSE 0.01
colorectal cancer KRAS_12-61 PTPRT Any mutation 175 18 TMB quintile 3 0.52 -0.33 1.40 1535.52 1.00 304 165 8 10 FALSE 0.60
colorectal cancer KRAS_12-61 PTPRT Any mutation 341 39 TMB quintile 4 -0.91 -1.67 -0.21 1210.87 1.00 420 332 30 9 FALSE 1.97
colorectal cancer KRAS_12-61 PTPRT Any mutation 315 59 TMB quintile 5 -0.40 -0.96 0.17 1420.34 1.00 279 291 35 24 FALSE 0.82
colorectal cancer KRAS_12-61 PTPRT Any mutation 39 66 TMB quintile 6 0.34 -0.32 1.02 1654.50 1.00 73 20 47 19 FALSE 0.50
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 155 17 TMB quintile 3 -0.23 -1.39 0.85 1365.07 1.00 458 151 13 4 FALSE 0.16
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 263 38 TMB quintile 4 0.05 -0.63 0.74 1592.84 1.00 476 249 24 14 FALSE 0.06
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 463 272 TMB quintile 5 -0.51 -0.80 -0.21 1516.28 1.00 615 388 197 75 FALSE 3.08
colorectal cancer KRAS_12-61 PTPRT Any mutation 870 182 TMB overall -0.13 -1.22 1.05 1588.64 1.00 1076 808 120 62 FALSE 0.09
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 882 348 TMB overall -0.26 -2.08 1.78 1398.80 1.00 1554 788 254 94 FALSE 0.10
non-small cell lung cancer KRAS_12-61 HGF Any mutation 262 27 TMB quintile 4 -0.31 -1.20 0.48 1522.01 1.00 482 254 19 8 FALSE 0.32
non-small cell lung cancer KRAS_12-61 HGF Any mutation 456 138 TMB quintile 5 0.09 -0.26 0.44 1228.57 1.00 690 402 84 54 FALSE 0.20
non-small cell lung cancer KRAS_12-61 HGF Any mutation 719 180 TMB overall -0.03 -2.08 2.29 1553.89 1.00 1179 656 117 63 FALSE 0.01
colorectal cancer KRAS_12-61 PIK3CA Any mutation 177 51 TMB quintile 3 0.92 0.39 1.49 1574.57 1.00 292 147 21 30 TRUE 2.90
colorectal cancer KRAS_12-61 PIK3CA Any mutation 343 146 TMB quintile 4 0.58 0.23 0.93 1374.43 1.00 388 263 66 80 TRUE 3.03
colorectal cancer KRAS_12-61 PIK3CA Any mutation 327 209 TMB quintile 5 0.41 0.09 0.74 1510.93 1.00 231 208 90 119 TRUE 1.81
colorectal cancer KRAS_12-61 PIK3CA Any mutation 40 95 TMB quintile 6 0.48 -0.19 1.15 1408.61 1.00 58 14 69 26 TRUE 0.79
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 83 18 TMB quintile 2 -0.75 -1.75 0.12 1614.12 1.00 341 82 17 1 TRUE 0.96
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 155 34 TMB quintile 3 -0.20 -0.89 0.49 1388.16 1.00 446 146 25 9 TRUE 0.25
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 263 56 TMB quintile 4 -0.62 -1.21 -0.05 1484.02 1.00 456 251 44 12 TRUE 1.47
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 455 123 TMB quintile 5 -0.34 -0.75 0.01 1510.21 1.00 691 418 86 37 TRUE 1.10
uterine cancer KRAS_12-61 PIK3CA Any mutation 13 33 TMB quintile 2 -0.04 -1.13 0.94 1461.59 1.00 103 10 30 3 TRUE 0.03
uterine cancer KRAS_12-61 PIK3CA Any mutation 26 103 TMB quintile 3 0.18 -0.57 0.94 1518.81 1.00 134 14 91 12 TRUE 0.20
uterine cancer KRAS_12-61 PIK3CA Any mutation 48 121 TMB quintile 4 0.60 0.05 1.20 1542.99 1.00 107 18 91 30 TRUE 1.36
uterine cancer KRAS_12-61 PIK3CA Any mutation 78 196 TMB quintile 5 0.13 -0.38 0.64 1602.70 1.00 92 29 147 49 TRUE 0.21
uterine cancer KRAS_12-61 PIK3CA Any mutation 10 95 TMB quintile 6 -0.16 -1.28 0.94 1380.99 1.00 13 2 87 8 TRUE 0.11
colorectal cancer KRAS_12-61 PIK3CA Any mutation 887 501 TMB overall 0.59 -0.38 1.59 1324.02 1.00 969 632 246 255 TRUE 0.67
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 956 231 TMB overall -0.47 -1.10 0.12 1479.56 1.00 1934 897 172 59 TRUE 0.89
uterine cancer KRAS_12-61 PIK3CA Any mutation 175 548 TMB overall 0.13 -0.69 1.04 1581.09 1.00 449 73 446 102 TRUE 0.12
colorectal cancer KRAS_12-61 ALK Any mutation 341 20 TMB quintile 4 0.30 -0.53 1.11 1617.07 1.00 441 330 9 11 TRUE 0.31
colorectal cancer KRAS_12-61 ALK Any mutation 313 42 TMB quintile 5 -0.20 -0.82 0.41 1440.31 1.00 292 294 23 19 TRUE 0.27
colorectal cancer KRAS_12-61 ALK Any mutation 37 45 TMB quintile 6 -0.45 -1.34 0.38 1540.99 1.00 81 29 37 8 TRUE 0.53
non-small cell lung cancer KRAS_12-61 ALK Any mutation 155 13 TMB quintile 3 -0.80 -2.27 0.54 1464.94 1.00 461 153 11 2 TRUE 0.60
non-small cell lung cancer KRAS_12-61 ALK Any mutation 262 22 TMB quintile 4 -0.06 -1.01 0.75 1431.05 1.00 487 254 14 8 TRUE 0.05
non-small cell lung cancer KRAS_12-61 ALK Any mutation 454 118 TMB quintile 5 -0.12 -0.53 0.28 1521.06 1.00 698 413 77 41 TRUE 0.26
colorectal cancer KRAS_12-61 ALK Any mutation 691 107 TMB overall -0.10 -1.53 1.41 1570.54 1.00 814 653 69 38 TRUE 0.05
non-small cell lung cancer KRAS_12-61 ALK Any mutation 872 164 TMB overall -0.61 -2.24 0.96 1450.04 1.00 1654 821 113 51 TRUE 0.34
colorectal cancer KRAS_12-61 RNF43 Any mutation 175 12 TMB quintile 3 -1.15 -2.66 0.20 1174.11 1.01 302 173 10 2 TRUE 0.95
colorectal cancer KRAS_12-61 RNF43 Any mutation 341 30 TMB quintile 4 -0.50 -1.31 0.23 1443.58 1.00 431 331 20 10 TRUE 0.70
colorectal cancer KRAS_12-61 RNF43 Any mutation 318 76 TMB quintile 5 -0.98 -1.49 -0.45 1591.39 1.00 268 296 54 22 TRUE 3.83
colorectal cancer KRAS_12-61 RNF43 Any mutation 43 146 TMB quintile 6 -0.47 -1.22 0.25 1407.67 1.00 35 14 117 29 TRUE 0.70
colorectal cancer KRAS_12-61 RNF43 Any mutation 877 264 TMB overall -0.78 -2.39 0.76 1551.63 1.00 1036 814 201 63 TRUE 0.50
colorectal cancer KRAS_12-61 PTEN Any mutation 341 29 TMB quintile 4 0.49 -0.22 1.21 1379.00 1.00 439 324 12 17 TRUE 0.78
colorectal cancer KRAS_12-61 PTEN Any mutation 315 69 TMB quintile 5 -0.49 -1.01 -0.01 1406.24 1.00 284 289 43 26 TRUE 1.27
colorectal cancer KRAS_12-61 PTEN Any mutation 40 80 TMB quintile 6 -0.22 -0.94 0.48 1480.73 1.00 67 23 63 17 TRUE 0.26
non-small cell lung cancer KRAS_12-61 PTEN Any mutation 155 17 TMB quintile 3 -1.60 -3.00 -0.58 1683.63 1.00 455 154 16 1 TRUE 2.03
non-small cell lung cancer KRAS_12-61 PTEN Any mutation 262 27 TMB quintile 4 -1.90 -3.27 -0.95 1571.90 1.00 475 261 26 1 TRUE 2.82
non-small cell lung cancer KRAS_12-61 PTEN Any mutation 454 75 TMB quintile 5 -1.12 -1.74 -0.56 1554.83 1.00 714 440 61 14 TRUE 3.73
uterine cancer KRAS_12-61 PTEN Any mutation 13 16 TMB quintile 2 -0.21 -1.90 1.17 1608.53 1.00 118 12 15 1 TRUE 0.10
uterine cancer KRAS_12-61 PTEN Any mutation 29 63 TMB quintile 3 0.67 -0.10 1.42 1445.74 1.00 177 18 52 11 TRUE 1.05
uterine cancer KRAS_12-61 PTEN Any mutation 54 120 TMB quintile 4 0.38 -0.17 0.96 1442.23 1.00 122 26 92 28 TRUE 0.68
uterine cancer KRAS_12-61 PTEN Any mutation 102 315 TMB quintile 5 0.83 0.22 1.50 1445.16 1.00 58 11 224 91 TRUE 1.95
uterine cancer KRAS_12-61 PTEN Any mutation 14 103 TMB quintile 6 1.08 -0.37 2.86 1515.96 1.00 13 0 89 14 TRUE 0.74
colorectal cancer KRAS_12-61 PTEN Any mutation 696 178 TMB overall -0.07 -1.65 1.54 1440.01 1.00 790 636 118 60 TRUE 0.03
non-small cell lung cancer KRAS_12-61 PTEN Any mutation 871 119 TMB overall -1.52 -2.65 -0.64 1391.53 1.00 1644 855 103 16 TRUE 2.60
uterine cancer KRAS_12-61 PTEN Any mutation 212 617 TMB overall 0.54 -0.65 1.71 1432.52 1.00 488 67 472 145 TRUE 0.43
colorectal cancer KRAS_12-61 BCOR Any mutation 341 11 TMB quintile 4 0.52 -0.56 1.72 1373.31 1.00 446 334 4 7 FALSE 0.43
colorectal cancer KRAS_12-61 BCOR Any mutation 313 39 TMB quintile 5 -0.17 -0.84 0.45 1585.33 1.00 295 295 21 18 FALSE 0.21
colorectal cancer KRAS_12-61 BCOR Any mutation 37 57 TMB quintile 6 -0.22 -0.98 0.52 1489.12 1.00 74 25 45 12 FALSE 0.24
non-small cell lung cancer KRAS_12-61 BCOR Any mutation 262 22 TMB quintile 4 -0.09 -0.87 0.60 1555.64 1.00 486 255 15 7 FALSE 0.08
non-small cell lung cancer KRAS_12-61 BCOR Any mutation 460 92 TMB quintile 5 0.31 -0.09 0.70 1558.55 1.00 720 419 51 41 FALSE 0.89
uterine cancer KRAS_12-61 BCOR Any mutation 44 19 TMB quintile 4 0.22 -0.89 1.21 1541.95 1.00 171 39 14 5 FALSE 0.17
uterine cancer KRAS_12-61 BCOR Any mutation 64 69 TMB quintile 5 0.31 -0.32 0.90 1545.12 1.00 155 44 49 20 FALSE 0.51
uterine cancer KRAS_12-61 BCOR Any mutation 7 46 TMB quintile 6 -0.89 -2.32 0.40 1452.49 1.00 31 5 44 2 FALSE 0.69
colorectal cancer KRAS_12-61 BCOR Any mutation 691 107 TMB overall 0.05 -1.64 1.85 1507.02 1.00 815 654 70 37 FALSE 0.02
non-small cell lung cancer KRAS_12-61 BCOR Any mutation 722 114 TMB overall 0.11 -1.18 1.23 1571.03 1.00 1206 674 66 48 FALSE 0.07
uterine cancer KRAS_12-61 BCOR Any mutation 115 134 TMB overall -0.12 -1.71 1.31 1592.69 1.00 357 88 107 27 FALSE 0.05
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 175 38 TMB quintile 3 0.69 0.06 1.28 1433.21 1.00 296 155 18 20 TRUE 1.57
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 342 35 TMB quintile 4 0.76 0.18 1.41 1199.75 1.00 438 319 12 23 TRUE 1.76
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 315 48 TMB quintile 5 0.24 -0.33 0.78 1131.79 1.00 291 289 22 26 TRUE 0.40
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 35 35 TMB quintile 6 0.54 -0.19 1.28 1389.39 1.00 84 24 24 11 TRUE 0.82
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 83 12 TMB quintile 2 -0.85 -1.95 0.13 1473.41 1.00 347 82 11 1 TRUE 0.97
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 155 22 TMB quintile 3 -1.26 -2.69 -0.30 1493.04 1.00 449 155 22 0 TRUE 1.46
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 264 33 TMB quintile 4 -0.37 -1.08 0.33 1521.04 1.00 479 253 22 11 TRUE 0.53
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 454 47 TMB quintile 5 -0.72 -1.34 -0.15 1267.30 1.00 733 443 36 11 TRUE 1.70
uterine cancer KRAS_12-61 CTNNB1 Any mutation 26 28 TMB quintile 3 -2.19 -3.95 -0.98 1241.03 1.00 187 26 28 0 TRUE 2.54
uterine cancer KRAS_12-61 CTNNB1 Any mutation 44 33 TMB quintile 4 -1.67 -2.91 -0.59 1503.11 1.00 155 41 30 3 TRUE 2.34
uterine cancer KRAS_12-61 CTNNB1 Any mutation 62 61 TMB quintile 5 -2.01 -3.10 -1.12 1382.81 1.00 145 59 58 3 TRUE 3.95
uterine cancer KRAS_12-61 CTNNB1 Any mutation 7 15 TMB quintile 6 -2.12 -3.89 -0.76 1252.31 1.00 41 7 15 0 TRUE 2.14
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 867 156 TMB overall 0.58 -0.24 1.50 1485.59 1.00 1109 787 76 80 TRUE 0.77
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 956 114 TMB overall -0.80 -1.67 -0.06 1597.11 1.00 2008 933 91 23 TRUE 1.26
uterine cancer KRAS_12-61 CTNNB1 Any mutation 139 137 TMB overall -1.98 -3.22 -0.99 1362.90 1.00 528 133 131 6 TRUE 3.25
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 36 15 TMB quintile 4 -0.42 -1.67 0.73 1504.95 1.00 94 33 12 3 TRUE 0.32
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 43 62 TMB quintile 5 -0.55 -1.36 0.17 1532.00 1.00 107 34 53 9 TRUE 0.79
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 6 16 TMB quintile 6 0.62 -0.79 2.38 1483.31 1.00 9 1 11 5 TRUE 0.36
colorectal cancer KRAS_12-61 ARID1A Any mutation 342 32 TMB quintile 4 0.06 -0.66 0.77 1240.16 1.00 433 327 17 15 TRUE 0.06
colorectal cancer KRAS_12-61 ARID1A Any mutation 320 116 TMB quintile 5 -0.80 -1.21 -0.40 1487.17 1.00 256 282 78 38 TRUE 3.92
colorectal cancer KRAS_12-61 ARID1A Any mutation 46 155 TMB quintile 6 -0.18 -0.93 0.51 1475.88 1.00 40 13 122 33 TRUE 0.20
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 155 12 TMB quintile 3 -0.27 -1.31 0.78 1617.29 1.00 462 152 9 3 TRUE 0.20
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 262 56 TMB quintile 4 -0.20 -0.80 0.33 1487.83 1.00 464 245 39 17 TRUE 0.31
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 464 187 TMB quintile 5 -0.26 -0.56 0.07 1386.17 1.00 652 404 127 60 TRUE 0.90
pancreatic cancer KRAS_12-61 ARID1A Any mutation 277 13 TMB quintile 2 -0.83 -1.70 0.03 1478.93 1.00 64 269 5 8 TRUE 1.19
pancreatic cancer KRAS_12-61 ARID1A Any mutation 454 44 TMB quintile 3 -0.16 -0.82 0.63 1060.75 1.00 64 416 6 38 TRUE 0.18
pancreatic cancer KRAS_12-61 ARID1A Any mutation 243 45 TMB quintile 4 -0.15 -0.86 0.55 1730.98 1.00 34 206 8 37 TRUE 0.18
pancreatic cancer KRAS_12-61 ARID1A Any mutation 39 17 TMB quintile 5 0.15 -0.75 1.10 1527.55 1.00 14 27 5 12 TRUE 0.13
uterine cancer KRAS_12-61 ARID1A Any mutation 26 28 TMB quintile 3 0.33 -0.86 1.40 1534.51 1.00 192 22 24 4 TRUE 0.25
uterine cancer KRAS_12-61 ARID1A Any mutation 48 77 TMB quintile 4 1.14 0.50 1.75 1525.50 1.00 139 22 51 26 TRUE 3.48
uterine cancer KRAS_12-61 ARID1A Any mutation 89 307 TMB quintile 5 0.70 0.03 1.43 1344.35 1.00 60 11 229 78 TRUE 1.33
uterine cancer KRAS_12-61 ARID1A Any mutation 13 108 TMB quintile 6 1.14 -0.55 3.37 1515.01 1.00 9 0 95 13 TRUE 0.60
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 85 93 TMB overall -0.07 -1.45 1.47 1128.41 1.00 210 68 76 17 TRUE 0.03
colorectal cancer KRAS_12-61 ARID1A Any mutation 708 303 TMB overall -0.30 -2.18 1.65 1684.45 1.00 729 622 217 86 TRUE 0.12
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 881 255 TMB overall -0.25 -1.35 0.88 1573.44 1.00 1578 801 175 80 TRUE 0.18
pancreatic cancer KRAS_12-61 ARID1A Any mutation 1013 119 TMB overall -0.26 -1.11 0.59 1388.84 1.00 176 918 24 95 TRUE 0.25
uterine cancer KRAS_12-61 ARID1A Any mutation 176 520 TMB overall 0.78 -0.65 2.31 1460.03 1.00 400 55 399 121 TRUE 0.48
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 341 22 TMB quintile 4 -0.15 -0.97 0.63 1492.66 1.00 438 332 13 9 TRUE 0.15
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 314 29 TMB quintile 5 0.18 -0.54 0.91 1579.34 1.00 302 298 13 16 TRUE 0.20
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 38 56 TMB quintile 6 0.20 -0.50 0.90 1660.17 1.00 77 23 41 15 TRUE 0.24
uterine cancer KRAS_12-61 PIK3R1 Any mutation 26 40 TMB quintile 3 -0.86 -1.97 0.12 1613.39 1.00 181 24 38 2 TRUE 0.93
uterine cancer KRAS_12-61 PIK3R1 Any mutation 46 68 TMB quintile 4 -0.58 -1.39 0.11 1536.13 1.00 136 37 59 9 TRUE 0.92
uterine cancer KRAS_12-61 PIK3R1 Any mutation 72 117 TMB quintile 5 0.07 -0.46 0.61 1549.35 1.00 133 41 86 31 TRUE 0.10
uterine cancer KRAS_12-61 PIK3R1 Any mutation 7 37 TMB quintile 6 -1.14 -2.67 0.00 1549.53 1.00 29 6 36 1 TRUE 1.06
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 693 107 TMB overall 0.05 -1.39 1.55 1535.30 1.00 817 653 67 40 TRUE 0.02
uterine cancer KRAS_12-61 PIK3R1 Any mutation 151 262 TMB overall -0.64 -1.63 0.18 1711.71 1.00 479 108 219 43 TRUE 0.77
colorectal cancer KRAS_12-61 FAT1 Any mutation 341 17 TMB quintile 4 -0.46 -1.49 0.51 1550.24 1.00 440 335 11 6 FALSE 0.43
colorectal cancer KRAS_12-61 FAT1 Any mutation 315 64 TMB quintile 5 -0.85 -1.39 -0.31 1197.60 1.00 276 295 44 20 FALSE 2.65
colorectal cancer KRAS_12-61 FAT1 Any mutation 51 145 TMB quintile 6 -0.06 -0.72 0.65 1525.31 1.00 47 16 110 35 FALSE 0.07
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 155 16 TMB quintile 3 -0.20 -1.33 0.83 1403.67 1.00 459 151 12 4 FALSE 0.14
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 262 43 TMB quintile 4 -0.47 -1.16 0.20 1518.36 1.00 473 251 32 11 FALSE 0.74
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 459 227 TMB quintile 5 -0.18 -0.47 0.12 1503.23 1.00 636 383 151 76 FALSE 0.61
uterine cancer KRAS_12-61 FAT1 Any mutation 63 49 TMB quintile 5 -0.21 -1.00 0.49 1478.46 1.00 172 53 39 10 FALSE 0.23
uterine cancer KRAS_12-61 FAT1 Any mutation 12 115 TMB quintile 6 0.44 -1.14 2.51 1491.07 1.00 16 1 104 11 FALSE 0.20
colorectal cancer KRAS_12-61 FAT1 Any mutation 707 226 TMB overall -0.45 -2.40 1.51 1276.47 1.00 763 646 165 61 FALSE 0.19
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 877 300 TMB overall -0.25 -1.73 1.39 1429.99 1.00 1575 785 208 92 FALSE 0.13
uterine cancer KRAS_12-61 FAT1 Any mutation 75 164 TMB overall 0.13 -2.78 3.31 1513.29 1.00 188 54 143 21 FALSE 0.03
colorectal cancer KRAS_12-61 CIC Any mutation 341 17 TMB quintile 4 0.03 -0.92 1.00 1604.64 1.00 442 333 9 8 TRUE 0.02
colorectal cancer KRAS_12-61 CIC Any mutation 316 40 TMB quintile 5 -0.45 -1.10 0.21 1541.67 1.00 291 300 24 16 TRUE 0.78
colorectal cancer KRAS_12-61 CIC Any mutation 37 79 TMB quintile 6 -0.36 -1.06 0.34 1404.55 1.00 64 22 64 15 TRUE 0.48
colorectal cancer KRAS_12-61 CIC Any mutation 694 136 TMB overall -0.29 -2.07 1.50 1428.26 1.00 797 655 97 39 TRUE 0.13
colorectal cancer KRAS_12-61 NCOR1 Any mutation 341 16 TMB quintile 4 -0.36 -1.37 0.55 1175.01 1.00 440 335 10 6 FALSE 0.33
colorectal cancer KRAS_12-61 NCOR1 Any mutation 314 32 TMB quintile 5 -0.81 -1.56 -0.09 1624.14 1.00 296 304 22 10 FALSE 1.50
colorectal cancer KRAS_12-61 NCOR1 Any mutation 38 81 TMB quintile 6 0.24 -0.47 0.97 1531.69 1.00 64 17 60 21 FALSE 0.29
non-small cell lung cancer KRAS_12-61 NCOR1 Any mutation 262 21 TMB quintile 4 -0.74 -1.66 0.03 1417.38 1.00 484 258 17 4 FALSE 1.07
non-small cell lung cancer KRAS_12-61 NCOR1 Any mutation 457 71 TMB quintile 5 -0.47 -1.01 0.04 1595.37 1.00 724 437 51 20 FALSE 1.11
colorectal cancer KRAS_12-61 NCOR1 Any mutation 693 129 TMB overall -0.34 -2.03 1.45 1571.09 1.00 800 656 92 37 FALSE 0.15
non-small cell lung cancer KRAS_12-61 NCOR1 Any mutation 719 92 TMB overall -0.61 -1.84 0.50 1477.37 1.00 1208 695 68 24 FALSE 0.56
colorectal cancer KRAS_12-61 POLE Any mutation 313 38 TMB quintile 5 -0.60 -1.30 0.05 1604.88 1.00 291 299 24 14 TRUE 1.09
colorectal cancer KRAS_12-61 POLE Any mutation 39 93 TMB quintile 6 0.15 -0.57 0.87 1720.20 1.00 59 16 70 23 TRUE 0.17
non-small cell lung cancer KRAS_12-61 POLE Any mutation 262 20 TMB quintile 4 0.00 -0.85 0.81 1451.98 1.00 487 255 13 7 TRUE 0.00
non-small cell lung cancer KRAS_12-61 POLE Any mutation 456 102 TMB quintile 5 0.33 -0.07 0.72 1381.36 1.00 717 411 57 45 TRUE 0.95
uterine cancer KRAS_12-61 POLE Any mutation 62 24 TMB quintile 5 -0.01 -0.99 0.86 1590.15 1.00 184 56 18 6 TRUE 0.00
uterine cancer KRAS_12-61 POLE Any mutation 9 80 TMB quintile 6 0.03 -1.41 1.68 1487.10 1.00 21 2 73 7 TRUE 0.01
colorectal cancer KRAS_12-61 POLE Any mutation 352 131 TMB overall -0.21 -2.64 2.21 1532.65 1.00 350 315 94 37 TRUE 0.06
non-small cell lung cancer KRAS_12-61 POLE Any mutation 718 122 TMB overall 0.20 -1.19 1.50 1465.06 1.00 1204 666 70 52 TRUE 0.11
uterine cancer KRAS_12-61 POLE Any mutation 71 104 TMB overall 0.04 -2.99 3.14 1521.09 1.00 205 58 91 13 TRUE 0.01
non-small cell lung cancer KRAS_12-61 NOTCH2 Any mutation 263 16 TMB quintile 4 0.08 -0.83 1.03 1537.97 1.00 488 256 9 7 TRUE 0.06
non-small cell lung cancer KRAS_12-61 NOTCH2 Any mutation 453 81 TMB quintile 5 -0.50 -1.00 -0.01 1528.14 1.00 712 432 60 21 TRUE 1.28
non-small cell lung cancer KRAS_12-61 NOTCH2 Any mutation 716 97 TMB overall -0.16 -1.73 1.65 1413.15 1.00 1200 688 69 28 TRUE 0.07
colorectal cancer KRAS_12-61 TGFBR2 Any mutation 314 47 TMB quintile 5 -0.24 -0.82 0.34 1281.20 1.00 291 293 26 21 TRUE 0.37
colorectal cancer KRAS_12-61 TGFBR2 Any mutation 35 57 TMB quintile 6 -0.01 -0.83 0.74 1367.94 1.00 65 21 43 14 TRUE 0.01
colorectal cancer KRAS_12-61 TGFBR2 Any mutation 349 104 TMB overall -0.14 -2.16 1.98 1516.07 1.00 356 314 69 35 TRUE 0.05
colorectal cancer KRAS_12-61 KMT2A Any mutation 341 16 TMB quintile 4 -0.62 -1.67 0.31 1557.60 1.00 439 336 11 5 FALSE 0.69
colorectal cancer KRAS_12-61 KMT2A Any mutation 314 43 TMB quintile 5 -0.36 -0.99 0.25 1580.89 1.00 291 296 25 18 FALSE 0.58
colorectal cancer KRAS_12-61 KMT2A Any mutation 41 84 TMB quintile 6 -0.04 -0.73 0.66 1558.90 1.00 67 21 64 20 FALSE 0.04
non-small cell lung cancer KRAS_12-61 KMT2A Any mutation 262 16 TMB quintile 4 -0.37 -1.34 0.58 1185.52 1.00 489 257 11 5 FALSE 0.35
non-small cell lung cancer KRAS_12-61 KMT2A Any mutation 455 80 TMB quintile 5 -0.44 -0.96 0.05 1242.76 1.00 715 433 58 22 FALSE 1.12
uterine cancer KRAS_12-61 KMT2A Any mutation 62 27 TMB quintile 5 0.04 -0.88 0.89 1457.01 1.00 181 55 20 7 FALSE 0.03
uterine cancer KRAS_12-61 KMT2A Any mutation 9 76 TMB quintile 6 -0.25 -1.64 1.28 1422.64 1.00 26 3 70 6 FALSE 0.13
colorectal cancer KRAS_12-61 KMT2A Any mutation 696 143 TMB overall -0.28 -1.86 1.27 1485.75 1.00 797 653 100 43 FALSE 0.14
non-small cell lung cancer KRAS_12-61 KMT2A Any mutation 717 96 TMB overall -0.40 -1.89 1.17 1359.85 1.00 1204 690 69 27 FALSE 0.22
uterine cancer KRAS_12-61 KMT2A Any mutation 71 103 TMB overall -0.03 -2.78 2.81 1245.39 1.00 207 58 90 13 FALSE 0.01
non-small cell lung cancer KRAS_12-61 PAK7 Any mutation 262 13 TMB quintile 4 0.01 -1.01 1.07 1558.51 1.00 489 257 8 5 FALSE 0.01
non-small cell lung cancer KRAS_12-61 PAK7 Any mutation 454 95 TMB quintile 5 0.11 -0.33 0.51 1393.44 1.00 714 417 58 37 FALSE 0.21
non-small cell lung cancer KRAS_12-61 PAK7 Any mutation 716 108 TMB overall 0.04 -1.68 1.60 1424.78 1.00 1203 674 66 42 FALSE 0.02
non-small cell lung cancer KRAS_12-61 STAG2 Any mutation 262 19 TMB quintile 4 -0.14 -0.97 0.61 1377.81 1.00 487 256 13 6 TRUE 0.14
non-small cell lung cancer KRAS_12-61 STAG2 Any mutation 455 76 TMB quintile 5 0.16 -0.30 0.61 1347.86 1.00 729 424 45 31 TRUE 0.30
non-small cell lung cancer KRAS_12-61 STAG2 Any mutation 717 95 TMB overall -0.02 -1.29 1.23 1478.11 1.00 1216 680 58 37 TRUE 0.01
non-small cell lung cancer KRAS_12-61 TERT Any mutation 156 13 TMB quintile 3 0.45 -0.43 1.43 1509.15 1.00 464 150 7 6 TRUE 0.45
non-small cell lung cancer KRAS_12-61 TERT Any mutation 262 34 TMB quintile 4 0.18 -0.45 0.81 1527.35 1.00 480 249 21 13 TRUE 0.24
non-small cell lung cancer KRAS_12-61 TERT Any mutation 456 98 TMB quintile 5 0.06 -0.38 0.46 1492.59 1.00 712 420 62 36 TRUE 0.10
non-small cell lung cancer KRAS_12-61 TERT Any mutation 874 145 TMB overall 0.23 -0.65 1.22 1377.97 1.00 1656 819 90 55 TRUE 0.22
colorectal cancer KRAS_12-61 BRCA2 Any mutation 341 21 TMB quintile 4 -0.14 -1.03 0.71 1499.10 1.00 438 332 12 9 TRUE 0.12
colorectal cancer KRAS_12-61 BRCA2 Any mutation 317 48 TMB quintile 5 -0.29 -0.86 0.28 1337.41 1.00 290 296 27 21 TRUE 0.48
colorectal cancer KRAS_12-61 BRCA2 Any mutation 43 116 TMB quintile 6 -0.73 -1.44 -0.05 1416.02 1.00 57 24 97 19 TRUE 1.41
non-small cell lung cancer KRAS_12-61 BRCA2 Any mutation 262 23 TMB quintile 4 -0.28 -1.26 0.56 1488.37 1.00 485 255 16 7 TRUE 0.26
non-small cell lung cancer KRAS_12-61 BRCA2 Any mutation 456 89 TMB quintile 5 -0.27 -0.75 0.20 1556.33 1.00 711 428 61 28 TRUE 0.59
uterine cancer KRAS_12-61 BRCA2 Any mutation 62 29 TMB quintile 5 -0.57 -1.62 0.35 1599.52 1.00 176 57 24 5 TRUE 0.58
uterine cancer KRAS_12-61 BRCA2 Any mutation 9 93 TMB quintile 6 -1.09 -2.45 0.32 1660.83 1.00 22 4 88 5 TRUE 0.92
colorectal cancer KRAS_12-61 BRCA2 Any mutation 701 185 TMB overall -0.37 -2.03 1.44 1463.78 1.00 785 652 136 49 TRUE 0.17
non-small cell lung cancer KRAS_12-61 BRCA2 Any mutation 719 126 TMB overall -0.17 -2.37 2.30 1603.07 1.00 1205 683 90 36 TRUE 0.05
uterine cancer KRAS_12-61 BRCA2 Any mutation 71 122 TMB overall -0.77 -3.44 2.16 1602.34 1.00 198 61 112 10 TRUE 0.23
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 175 12 TMB quintile 3 0.69 -0.42 1.86 1222.22 1.00 307 168 5 7 TRUE 0.64
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 341 17 TMB quintile 4 0.26 -0.65 1.23 1581.90 1.00 442 332 8 9 TRUE 0.24
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 313 50 TMB quintile 5 -0.58 -1.19 0.01 1453.81 1.00 286 295 32 18 TRUE 1.26
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 36 120 TMB quintile 6 -0.70 -1.45 0.03 1508.82 1.00 42 17 101 19 TRUE 1.20
non-small cell lung cancer KRAS_12-61 NOTCH3 Any mutation 262 21 TMB quintile 4 -0.13 -1.09 0.72 1313.06 1.00 487 255 14 7 TRUE 0.11
non-small cell lung cancer KRAS_12-61 NOTCH3 Any mutation 454 82 TMB quintile 5 -0.20 -0.67 0.26 1391.07 1.00 719 427 55 27 TRUE 0.38
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 865 199 TMB overall -0.07 -1.63 1.57 1383.47 1.00 1077 812 146 53 TRUE 0.03
non-small cell lung cancer KRAS_12-61 NOTCH3 Any mutation 717 114 TMB overall -0.06 -2.38 2.33 1450.15 1.00 1215 682 79 35 TRUE 0.02
colorectal cancer KRAS_12-61 NOTCH4 Any mutation 333 21 TMB quintile 4 0.00 -0.84 0.81 1330.26 1.00 430 323 11 10 TRUE 0.00
colorectal cancer KRAS_12-61 NOTCH4 Any mutation 296 37 TMB quintile 5 -1.03 -1.82 -0.35 1223.55 1.01 267 286 27 10 TRUE 2.23
colorectal cancer KRAS_12-61 NOTCH4 Any mutation 39 59 TMB quintile 6 -0.19 -0.97 0.53 1358.24 1.00 68 25 45 14 TRUE 0.20
non-small cell lung cancer KRAS_12-61 NOTCH4 Any mutation 262 17 TMB quintile 4 -0.86 -1.97 0.15 1195.43 1.00 483 259 14 3 TRUE 0.93
non-small cell lung cancer KRAS_12-61 NOTCH4 Any mutation 453 107 TMB quintile 5 -0.27 -0.71 0.15 1509.60 1.00 696 419 73 34 TRUE 0.69
colorectal cancer KRAS_12-61 NOTCH4 Any mutation 668 117 TMB overall -0.40 -1.97 1.19 1485.02 1.00 765 634 83 34 TRUE 0.21
non-small cell lung cancer KRAS_12-61 NOTCH4 Any mutation 715 124 TMB overall -0.51 -2.17 1.24 1428.14 1.00 1179 678 87 37 TRUE 0.26
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 83 12 TMB quintile 2 0.80 -0.24 1.77 1509.55 1.00 351 78 7 5 FALSE 0.91
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 155 50 TMB quintile 3 1.13 0.58 1.71 1616.49 1.00 446 130 25 25 FALSE 4.12
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 264 129 TMB quintile 4 0.66 0.28 1.03 1331.00 1.00 434 203 68 61 FALSE 3.23
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 460 336 TMB quintile 5 -0.12 -0.39 0.13 1493.50 1.00 561 344 220 116 FALSE 0.44
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 962 527 TMB overall 0.61 -0.38 1.64 1532.43 1.00 1792 755 320 207 FALSE 0.63
non-small cell lung cancer KRAS_12-61 KDM5C Any mutation 262 16 TMB quintile 4 -0.10 -1.04 0.73 1435.04 1.00 489 257 11 5 FALSE 0.08
non-small cell lung cancer KRAS_12-61 KDM5C Any mutation 456 70 TMB quintile 5 0.30 -0.16 0.77 1495.63 1.00 733 425 39 31 FALSE 0.70
non-small cell lung cancer KRAS_12-61 KDM5C Any mutation 718 86 TMB overall 0.11 -1.24 1.36 1508.84 1.00 1222 682 50 36 FALSE 0.07
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 155 33 TMB quintile 3 0.19 -0.51 0.91 1451.95 1.00 450 144 22 11 TRUE 0.22
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 262 43 TMB quintile 4 -0.25 -0.88 0.36 1510.54 1.00 471 249 30 13 TRUE 0.36
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 460 178 TMB quintile 5 -0.76 -1.10 -0.41 1564.74 1.00 641 420 138 40 TRUE 4.52
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 277 34 TMB quintile 2 1.47 0.57 2.56 1325.37 1.00 68 244 1 33 TRUE 2.47
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 461 146 TMB quintile 3 1.83 1.12 2.64 1399.86 1.00 65 320 5 141 TRUE 5.67
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 246 96 TMB quintile 4 1.81 0.96 2.68 1446.05 1.00 37 155 5 91 TRUE 4.50
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 877 254 TMB overall -0.30 -1.24 0.69 1571.20 1.00 1562 813 190 64 TRUE 0.27
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 984 276 TMB overall 1.68 0.82 2.69 1464.28 1.00 170 719 11 265 TRUE 3.22
non-small cell lung cancer KRAS_12-61 EPHB1 Any mutation 262 19 TMB quintile 4 0.18 -0.77 1.07 1452.36 1.00 489 254 11 8 FALSE 0.15
non-small cell lung cancer KRAS_12-61 EPHB1 Any mutation 456 117 TMB quintile 5 -0.65 -1.08 -0.22 1420.03 1.00 685 427 88 29 FALSE 2.55
non-small cell lung cancer KRAS_12-61 EPHB1 Any mutation 719 152 TMB overall -0.82 -3.60 1.71 1227.64 1.00 1182 682 115 37 FALSE 0.27
uterine cancer KRAS_12-61 PPP2R1A Any mutation 26 44 TMB quintile 3 -0.22 -1.10 0.65 1489.23 1.00 177 21 39 5 FALSE 0.22
uterine cancer KRAS_12-61 PPP2R1A Any mutation 44 46 TMB quintile 4 -0.39 -1.15 0.37 1495.59 1.00 147 37 39 7 FALSE 0.49
uterine cancer KRAS_12-61 PPP2R1A Any mutation 62 25 TMB quintile 5 -0.58 -1.54 0.28 1618.57 1.00 179 58 21 4 FALSE 0.67
uterine cancer KRAS_12-61 PPP2R1A Any mutation 8 30 TMB quintile 6 -0.60 -1.74 0.44 1480.89 1.00 38 6 28 2 FALSE 0.57
uterine cancer KRAS_12-61 PPP2R1A Any mutation 140 145 TMB overall -0.44 -1.29 0.42 1494.78 1.00 541 122 127 18 FALSE 0.51
colorectal cancer KRAS_12-61 ERBB3 Any mutation 342 27 TMB quintile 4 -0.14 -0.87 0.59 1514.21 1.00 434 331 16 11 TRUE 0.16
colorectal cancer KRAS_12-61 ERBB3 Any mutation 313 39 TMB quintile 5 0.04 -0.58 0.69 1624.34 1.00 295 293 19 20 TRUE 0.04
colorectal cancer KRAS_12-61 ERBB3 Any mutation 36 51 TMB quintile 6 0.29 -0.44 1.01 1558.13 1.00 80 22 37 14 TRUE 0.36
colorectal cancer KRAS_12-61 ERBB3 Any mutation 691 117 TMB overall 0.02 -1.32 1.33 1447.24 1.00 809 646 72 45 TRUE 0.01
colorectal cancer KRAS_12-61 SMAD4 Any mutation 176 51 TMB quintile 3 0.12 -0.39 0.62 1484.45 1.00 284 154 29 22 TRUE 0.18
colorectal cancer KRAS_12-61 SMAD4 Any mutation 343 129 TMB quintile 4 -0.02 -0.36 0.33 1372.76 1.00 380 288 74 55 TRUE 0.04
colorectal cancer KRAS_12-61 SMAD4 Any mutation 320 138 TMB quintile 5 0.00 -0.36 0.36 1414.58 1.00 252 253 71 67 TRUE 0.00
colorectal cancer KRAS_12-61 SMAD4 Any mutation 36 31 TMB quintile 6 -0.19 -0.92 0.43 1328.21 1.00 87 30 25 6 TRUE 0.24
non-small cell lung cancer KRAS_12-61 SMAD4 Any mutation 155 21 TMB quintile 3 -0.55 -1.32 0.14 1381.62 1.00 453 152 18 3 TRUE 0.87
non-small cell lung cancer KRAS_12-61 SMAD4 Any mutation 262 36 TMB quintile 4 -0.52 -1.16 0.08 1485.28 1.00 476 254 28 8 TRUE 1.01
non-small cell lung cancer KRAS_12-61 SMAD4 Any mutation 454 49 TMB quintile 5 -0.35 -0.88 0.21 1437.12 1.00 736 438 33 16 TRUE 0.67
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 277 37 TMB quintile 2 0.54 -0.17 1.39 1434.32 1.00 65 244 4 33 TRUE 0.78
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 457 119 TMB quintile 3 0.64 0.07 1.23 1614.62 1.00 59 349 11 108 TRUE 1.49
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 240 82 TMB quintile 4 0.99 0.32 1.76 1612.69 1.00 36 164 6 76 TRUE 2.29
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 40 25 TMB quintile 5 1.03 0.22 1.90 1493.01 1.00 13 20 5 20 TRUE 1.80
colorectal cancer KRAS_12-61 SMAD4 Any mutation 875 349 TMB overall -0.03 -0.58 0.48 1257.96 1.00 1003 725 199 150 TRUE 0.04
non-small cell lung cancer KRAS_12-61 SMAD4 Any mutation 871 106 TMB overall -0.47 -1.14 0.11 1332.70 1.00 1665 844 79 27 TRUE 0.86
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 1014 263 TMB overall 0.79 0.07 1.59 1458.15 1.00 173 777 26 237 TRUE 1.39
colorectal cancer KRAS_12-61 ATM Any mutation 345 46 TMB quintile 4 0.20 -0.37 0.76 1380.67 1.00 428 322 23 23 TRUE 0.30
colorectal cancer KRAS_12-61 ATM Any mutation 319 78 TMB quintile 5 -0.06 -0.51 0.39 1464.50 1.00 276 281 40 38 TRUE 0.11
colorectal cancer KRAS_12-61 ATM Any mutation 41 94 TMB quintile 6 -0.02 -0.71 0.62 1361.26 1.00 67 20 73 21 TRUE 0.02
non-small cell lung cancer KRAS_12-61 ATM Any mutation 83 15 TMB quintile 2 0.93 0.08 1.70 1288.57 1.00 350 77 9 6 TRUE 1.66
non-small cell lung cancer KRAS_12-61 ATM Any mutation 155 20 TMB quintile 3 0.97 0.26 1.71 1444.95 1.00 461 145 10 10 TRUE 2.05
non-small cell lung cancer KRAS_12-61 ATM Any mutation 270 76 TMB quintile 4 1.27 0.84 1.75 1443.19 1.00 475 222 28 48 TRUE 7.44
non-small cell lung cancer KRAS_12-61 ATM Any mutation 468 166 TMB quintile 5 0.80 0.47 1.11 1585.09 1.00 697 380 78 88 TRUE 6.19
uterine cancer KRAS_12-61 ATM Any mutation 63 46 TMB quintile 5 -0.50 -1.31 0.29 1628.26 1.00 170 55 38 8 TRUE 0.64
uterine cancer KRAS_12-61 ATM Any mutation 10 101 TMB quintile 6 -0.73 -2.01 0.56 1511.13 1.00 18 3 94 7 TRUE 0.57
colorectal cancer KRAS_12-61 ATM Any mutation 705 218 TMB overall 0.06 -1.43 1.55 1414.94 1.00 771 623 136 82 TRUE 0.03
non-small cell lung cancer KRAS_12-61 ATM Any mutation 976 277 TMB overall 1.00 0.30 1.71 1267.81 1.00 1983 824 125 152 TRUE 2.39
uterine cancer KRAS_12-61 ATM Any mutation 73 147 TMB overall -0.64 -3.17 1.97 1513.24 1.00 188 58 132 15 TRUE 0.21
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 155 33 TMB quintile 3 -1.36 -2.28 -0.59 1536.78 1.00 440 153 31 2 TRUE 2.84
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 262 50 TMB quintile 4 -1.22 -1.91 -0.58 1400.24 1.00 457 255 43 7 TRUE 3.58
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 454 124 TMB quintile 5 -0.98 -1.41 -0.56 1460.68 1.00 675 429 99 25 TRUE 5.20
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 871 207 TMB overall -1.19 -1.92 -0.51 1315.23 1.00 1572 837 173 34 TRUE 3.14
cancer of unknown primary KRAS_12-61 KMT2D Any mutation 36 14 TMB quintile 3 -1.41 -3.35 0.12 1568.39 1.00 96 35 13 1 FALSE 0.99
cancer of unknown primary KRAS_12-61 KMT2D Any mutation 36 11 TMB quintile 4 -0.19 -1.52 1.07 1595.29 1.00 98 33 8 3 FALSE 0.11
cancer of unknown primary KRAS_12-61 KMT2D Any mutation 41 67 TMB quintile 5 -0.74 -1.56 0.03 1477.70 1.00 99 32 58 9 FALSE 1.18
colorectal cancer KRAS_12-61 KMT2D Any mutation 341 27 TMB quintile 4 -0.70 -1.59 0.13 1238.09 1.00 432 333 19 8 FALSE 0.94
colorectal cancer KRAS_12-61 KMT2D Any mutation 319 104 TMB quintile 5 -0.70 -1.13 -0.27 1448.68 1.00 268 283 68 36 FALSE 2.84
colorectal cancer KRAS_12-61 KMT2D Any mutation 55 245 TMB quintile 6 -0.54 -1.48 0.44 1179.98 1.00 13 6 196 49 FALSE 0.59
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 155 15 TMB quintile 3 -0.18 -1.38 0.85 1420.88 1.00 460 151 11 4 FALSE 0.12
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 262 42 TMB quintile 4 -0.23 -0.95 0.44 1342.25 1.00 474 249 29 13 FALSE 0.29
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 459 251 TMB quintile 5 -0.80 -1.13 -0.50 1460.52 1.00 611 402 194 57 FALSE 5.98
uterine cancer KRAS_12-61 KMT2D Any mutation 44 14 TMB quintile 4 -0.59 -2.27 0.72 1258.26 1.00 174 42 12 2 FALSE 0.36
uterine cancer KRAS_12-61 KMT2D Any mutation 67 129 TMB quintile 5 -0.24 -0.80 0.29 1442.31 1.00 119 40 102 27 FALSE 0.41
uterine cancer KRAS_12-61 KMT2D Any mutation 12 109 TMB quintile 6 -0.66 -1.95 0.74 1306.00 1.00 15 3 100 9 FALSE 0.47
cancer of unknown primary KRAS_12-61 KMT2D Any mutation 117 123 TMB overall -0.54 -2.18 1.12 1262.20 1.00 297 100 106 17 FALSE 0.29
colorectal cancer KRAS_12-61 KMT2D Any mutation 715 376 TMB overall -0.57 -2.81 1.73 1487.25 1.00 713 622 283 93 FALSE 0.20
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 877 320 TMB overall -0.70 -2.47 0.88 1581.58 1.00 1552 803 246 74 FALSE 0.41
uterine cancer KRAS_12-61 KMT2D Any mutation 123 252 TMB overall -0.52 -2.57 1.49 1521.51 1.00 308 85 214 38 FALSE 0.21
colorectal cancer KRAS_12-61 TSC2 Any mutation 316 42 TMB quintile 5 -0.45 -1.12 0.19 1633.17 1.00 292 299 25 17 TRUE 0.77
colorectal cancer KRAS_12-61 TSC2 Any mutation 36 56 TMB quintile 6 -0.38 -1.21 0.39 1433.06 1.00 73 25 45 11 TRUE 0.46
colorectal cancer KRAS_12-61 TSC2 Any mutation 352 98 TMB overall -0.39 -2.43 1.64 1248.59 1.00 365 324 70 28 TRUE 0.16
colorectal cancer KRAS_12-61 APC Any mutation 28 78 TMB quintile 2 -0.74 -1.44 -0.06 1630.92 1.00 50 18 68 10 TRUE 1.44
colorectal cancer KRAS_12-61 APC Any mutation 207 428 TMB quintile 3 -0.43 -0.78 -0.06 1466.68 1.00 89 69 290 138 TRUE 1.72
colorectal cancer KRAS_12-61 APC Any mutation 482 966 TMB quintile 4 -0.03 -0.35 0.31 1666.30 1.00 84 68 552 414 TRUE 0.07
colorectal cancer KRAS_12-61 APC Any mutation 519 822 TMB quintile 5 0.74 0.40 1.07 1443.90 1.00 96 55 358 464 TRUE 4.88
colorectal cancer KRAS_12-61 APC Any mutation 69 225 TMB quintile 6 0.00 -0.58 0.59 1467.55 1.00 36 11 167 58 TRUE 0.00
non-small cell lung cancer KRAS_12-61 APC Any mutation 155 20 TMB quintile 3 -0.32 -1.20 0.51 1467.66 1.00 456 150 15 5 TRUE 0.34
non-small cell lung cancer KRAS_12-61 APC Any mutation 262 31 TMB quintile 4 -0.91 -1.86 -0.12 1206.36 1.00 473 258 27 4 TRUE 1.44
non-small cell lung cancer KRAS_12-61 APC Any mutation 457 101 TMB quintile 5 -0.15 -0.59 0.27 1406.50 1.00 709 422 66 35 TRUE 0.32
uterine cancer KRAS_12-61 APC Any mutation 63 35 TMB quintile 5 0.05 -0.82 0.85 1518.69 1.00 182 54 26 9 TRUE 0.04
uterine cancer KRAS_12-61 APC Any mutation 11 84 TMB quintile 6 -0.81 -2.00 0.38 1522.69 1.00 26 5 78 6 TRUE 0.72
colorectal cancer KRAS_12-61 APC Any mutation 1305 2519 TMB overall -0.08 -0.71 0.51 1322.72 1.00 355 221 1435 1084 TRUE 0.10
non-small cell lung cancer KRAS_12-61 APC Any mutation 874 152 TMB overall -0.47 -1.40 0.35 1362.00 1.00 1638 830 108 44 TRUE 0.57
uterine cancer KRAS_12-61 APC Any mutation 74 119 TMB overall -0.38 -2.93 2.26 1567.23 1.00 208 59 104 15 TRUE 0.11
colorectal cancer KRAS_12-61 ERBB2 Any mutation 341 17 TMB quintile 4 -0.41 -1.36 0.47 1596.79 1.00 439 335 11 6 TRUE 0.43
colorectal cancer KRAS_12-61 ERBB2 Any mutation 313 33 TMB quintile 5 -0.31 -1.01 0.35 1352.07 1.00 294 299 19 14 TRUE 0.42
colorectal cancer KRAS_12-61 ERBB2 Any mutation 35 42 TMB quintile 6 0.32 -0.46 1.09 1572.64 1.00 85 23 30 12 TRUE 0.37
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 83 14 TMB quintile 2 -2.19 -3.70 -1.05 1497.80 1.00 344 83 14 0 TRUE 3.00
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 155 27 TMB quintile 3 -1.80 -2.90 -0.74 1487.65 1.00 447 152 24 3 TRUE 3.03
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 262 32 TMB quintile 4 -2.44 -3.89 -1.42 1583.69 1.00 470 262 32 0 TRUE 3.98
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 454 40 TMB quintile 5 -1.96 -2.89 -1.12 1653.62 1.00 736 450 36 4 TRUE 4.76
colorectal cancer KRAS_12-61 ERBB2 Any mutation 689 92 TMB overall -0.16 -1.73 1.18 1370.30 1.00 818 657 60 32 TRUE 0.09
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 954 113 TMB overall -2.09 -3.11 -1.18 1513.93 1.00 1997 947 106 7 TRUE 4.74
uterine cancer KRAS_12-61 JAK1 Any mutation 67 88 TMB quintile 5 0.25 -0.34 0.83 1335.65 1.00 155 44 65 23 TRUE 0.41
uterine cancer KRAS_12-61 JAK1 Any mutation 10 52 TMB quintile 6 1.16 -0.20 3.10 1418.26 1.00 27 1 43 9 TRUE 0.77
uterine cancer KRAS_12-61 JAK1 Any mutation 77 140 TMB overall 0.64 -1.37 3.13 1398.95 1.00 182 45 108 32 TRUE 0.25
colorectal cancer KRAS_12-61 ARID2 Any mutation 341 12 TMB quintile 4 -0.22 -1.29 0.78 1389.53 1.00 443 336 7 5 FALSE 0.17
colorectal cancer KRAS_12-61 ARID2 Any mutation 314 31 TMB quintile 5 0.03 -0.67 0.78 1520.25 1.00 299 298 15 16 FALSE 0.03
colorectal cancer KRAS_12-61 ARID2 Any mutation 35 66 TMB quintile 6 -0.29 -1.02 0.46 1528.30 1.00 66 22 53 13 FALSE 0.35
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 155 19 TMB quintile 3 -0.66 -1.75 0.22 1488.74 1.00 454 153 17 2 FALSE 0.75
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 262 35 TMB quintile 4 -0.05 -0.70 0.56 1575.64 1.00 480 249 22 13 FALSE 0.05
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 455 111 TMB quintile 5 -0.23 -0.66 0.16 1558.06 1.00 703 420 76 35 FALSE 0.59
colorectal cancer KRAS_12-61 ARID2 Any mutation 690 109 TMB overall -0.12 -1.83 1.78 1448.49 1.00 808 656 75 34 FALSE 0.05
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 872 165 TMB overall -0.32 -1.23 0.45 1534.90 1.00 1637 822 115 50 FALSE 0.35
colorectal cancer KRAS_12-61 MTOR Any mutation 341 19 TMB quintile 4 1.09 0.17 2.04 1358.04 1.00 445 327 5 14 TRUE 1.68
colorectal cancer KRAS_12-61 MTOR Any mutation 314 40 TMB quintile 5 0.00 -0.63 0.65 1413.09 1.00 293 294 20 20 TRUE 0.00
colorectal cancer KRAS_12-61 MTOR Any mutation 40 70 TMB quintile 6 -0.12 -0.84 0.61 1425.44 1.00 68 24 54 16 TRUE 0.13
non-small cell lung cancer KRAS_12-61 MTOR Any mutation 155 14 TMB quintile 3 -0.32 -1.31 0.46 1561.51 1.00 459 153 12 2 TRUE 0.32
non-small cell lung cancer KRAS_12-61 MTOR Any mutation 263 21 TMB quintile 4 -0.04 -0.76 0.63 1405.93 1.00 487 255 13 8 TRUE 0.03
non-small cell lung cancer KRAS_12-61 MTOR Any mutation 456 70 TMB quintile 5 0.02 -0.44 0.45 1521.65 1.00 725 430 44 26 TRUE 0.03
colorectal cancer KRAS_12-61 MTOR Any mutation 695 129 TMB overall 0.32 -1.76 2.20 1519.68 1.01 806 645 79 50 TRUE 0.13
non-small cell lung cancer KRAS_12-61 MTOR Any mutation 874 105 TMB overall -0.10 -0.92 0.65 1484.77 1.00 1671 838 69 36 TRUE 0.09
colorectal cancer KRAS_12-61 NOTCH1 Any mutation 314 48 TMB quintile 5 -1.28 -1.97 -0.62 1655.92 1.00 279 303 37 11 TRUE 3.69
colorectal cancer KRAS_12-61 NOTCH1 Any mutation 48 112 TMB quintile 6 0.46 -0.29 1.19 1547.48 1.00 53 14 78 34 TRUE 0.68
non-small cell lung cancer KRAS_12-61 NOTCH1 Any mutation 262 15 TMB quintile 4 -0.53 -1.59 0.43 1433.44 1.00 489 258 11 4 TRUE 0.54
non-small cell lung cancer KRAS_12-61 NOTCH1 Any mutation 455 97 TMB quintile 5 -0.57 -1.07 -0.11 1414.09 1.00 702 430 72 25 TRUE 1.72
colorectal cancer KRAS_12-61 NOTCH1 Any mutation 362 160 TMB overall -0.35 -3.00 2.35 1570.22 1.00 332 317 115 45 TRUE 0.10
non-small cell lung cancer KRAS_12-61 NOTCH1 Any mutation 717 112 TMB overall -0.58 -2.26 1.08 1485.46 1.00 1191 688 83 29 TRUE 0.32
colorectal cancer KRAS_12-61 SETD2 Any mutation 175 11 TMB quintile 3 -1.63 -3.45 -0.27 1670.94 1.00 303 174 10 1 FALSE 1.31
colorectal cancer KRAS_12-61 SETD2 Any mutation 314 31 TMB quintile 5 -1.13 -1.92 -0.38 1512.06 1.00 292 306 23 8 FALSE 2.31
colorectal cancer KRAS_12-61 SETD2 Any mutation 40 64 TMB quintile 6 -0.11 -0.82 0.61 1515.71 1.00 71 24 48 16 FALSE 0.12
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 83 14 TMB quintile 2 -0.98 -2.49 0.12 1330.27 1.00 344 83 14 0 FALSE 0.86
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 156 22 TMB quintile 3 -0.82 -1.87 0.04 1380.26 1.00 456 154 20 2 FALSE 1.02
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 263 59 TMB quintile 4 -0.21 -0.76 0.29 1369.02 1.00 467 245 41 18 FALSE 0.37
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 462 110 TMB quintile 5 0.08 -0.30 0.48 1306.56 1.00 711 418 66 44 FALSE 0.17
colorectal cancer KRAS_12-61 SETD2 Any mutation 529 106 TMB overall -0.91 -2.60 0.80 1479.88 1.00 666 504 81 25 FALSE 0.54
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 964 205 TMB overall -0.48 -1.38 0.23 1339.12 1.00 1978 900 141 64 FALSE 0.58
non-small cell lung cancer KRAS_12-61 PBRM1 Any mutation 264 21 TMB quintile 4 0.28 -0.57 1.18 1348.15 1.00 490 254 11 10 TRUE 0.27
non-small cell lung cancer KRAS_12-61 PBRM1 Any mutation 454 79 TMB quintile 5 -0.51 -1.06 0.01 1408.23 1.00 719 434 59 20 TRUE 1.27
non-small cell lung cancer KRAS_12-61 PBRM1 Any mutation 718 100 TMB overall -0.10 -1.54 1.63 1422.56 1.00 1209 688 70 30 TRUE 0.04
colorectal cancer KRAS_12-61 EPHA3 Any mutation 342 17 TMB quintile 4 -0.19 -1.11 0.70 1388.41 1.00 440 335 10 7 FALSE 0.16
colorectal cancer KRAS_12-61 EPHA3 Any mutation 313 41 TMB quintile 5 0.04 -0.55 0.65 1445.98 1.00 294 292 20 21 FALSE 0.04
colorectal cancer KRAS_12-61 EPHA3 Any mutation 37 44 TMB quintile 6 0.04 -0.79 0.81 1423.97 1.00 81 26 33 11 FALSE 0.03
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 155 15 TMB quintile 3 0.57 -0.44 1.53 1526.89 1.00 462 149 9 6 FALSE 0.57
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 262 28 TMB quintile 4 0.60 -0.11 1.31 1375.39 1.00 486 248 14 14 FALSE 0.97
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 461 182 TMB quintile 5 -0.01 -0.35 0.29 1542.19 1.00 665 394 115 67 FALSE 0.03
colorectal cancer KRAS_12-61 EPHA3 Any mutation 692 102 TMB overall -0.05 -1.42 1.34 1420.19 1.00 815 653 63 39 FALSE 0.02
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 879 237 TMB overall 0.38 -1.23 2.16 1283.58 1.00 1621 791 149 88 FALSE 0.18
non-small cell lung cancer KRAS_12-61 KDR Any mutation 262 21 TMB quintile 4 0.36 -0.47 1.18 1485.43 1.00 489 252 11 10 TRUE 0.40
non-small cell lung cancer KRAS_12-61 KDR Any mutation 457 109 TMB quintile 5 -0.22 -0.62 0.17 1405.62 1.00 697 422 74 35 TRUE 0.54
non-small cell lung cancer KRAS_12-61 KDR Any mutation 719 130 TMB overall 0.08 -1.51 1.83 1205.92 1.00 1186 674 85 45 TRUE 0.04
colorectal cancer KRAS_12-61 PTCH1 Any mutation 314 35 TMB quintile 5 -0.72 -1.46 -0.04 1522.95 1.00 291 302 23 12 TRUE 1.37
colorectal cancer KRAS_12-61 PTCH1 Any mutation 43 99 TMB quintile 6 0.03 -0.64 0.70 1580.81 1.00 56 18 74 25 TRUE 0.03
colorectal cancer KRAS_12-61 PTCH1 Any mutation 357 134 TMB overall -0.37 -3.07 2.24 1574.61 1.00 347 320 97 37 TRUE 0.11
colorectal cancer KRAS_12-61 TET1 Any mutation 296 26 TMB quintile 5 -0.69 -1.51 0.12 1328.32 1.00 278 287 17 9 FALSE 1.02
colorectal cancer KRAS_12-61 TET1 Any mutation 41 67 TMB quintile 6 0.10 -0.57 0.78 1517.81 1.00 72 23 49 18 FALSE 0.11
non-small cell lung cancer KRAS_12-61 TET1 Any mutation 262 16 TMB quintile 4 -0.64 -1.95 0.45 1418.99 1.00 485 258 12 4 FALSE 0.55
non-small cell lung cancer KRAS_12-61 TET1 Any mutation 456 89 TMB quintile 5 -0.15 -0.63 0.30 1472.75 1.00 713 425 58 31 FALSE 0.27
colorectal cancer KRAS_12-61 TET1 Any mutation 337 93 TMB overall -0.35 -3.04 2.36 1442.95 1.00 350 310 66 27 FALSE 0.11
non-small cell lung cancer KRAS_12-61 TET1 Any mutation 719 120 TMB overall -1.06 -3.92 1.54 1522.48 1.00 1202 684 85 35 FALSE 0.36
uterine cancer KRAS_12-61 FGFR2 Any mutation 44 23 TMB quintile 4 -1.28 -2.73 0.03 1492.28 1.00 166 41 20 3 TRUE 1.18
uterine cancer KRAS_12-61 FGFR2 Any mutation 62 52 TMB quintile 5 -2.05 -3.36 -0.94 1463.93 1.00 156 60 50 2 TRUE 3.06
uterine cancer KRAS_12-61 FGFR2 Any mutation 7 18 TMB quintile 6 -2.08 -4.39 -0.56 1429.03 1.00 41 7 18 0 TRUE 1.53
uterine cancer KRAS_12-61 FGFR2 Any mutation 113 93 TMB overall -1.79 -3.42 -0.50 1306.83 1.00 363 108 88 5 TRUE 1.80
non-small cell lung cancer KRAS_12-61 TBX3 Any mutation 262 11 TMB quintile 4 -0.16 -1.28 0.99 1386.93 1.00 493 258 7 4 FALSE 0.11
non-small cell lung cancer KRAS_12-61 TBX3 Any mutation 454 108 TMB quintile 5 -0.28 -0.70 0.14 1568.23 1.00 702 421 75 33 FALSE 0.73
non-small cell lung cancer KRAS_12-61 TBX3 Any mutation 716 119 TMB overall -0.22 -2.02 1.62 1454.13 1.00 1195 679 82 37 FALSE 0.09
colorectal cancer KRAS_12-61 SMAD3 Any mutation 175 12 TMB quintile 3 -0.07 -1.04 0.83 1395.61 1.00 304 171 8 4 TRUE 0.06
colorectal cancer KRAS_12-61 SMAD3 Any mutation 344 27 TMB quintile 4 0.26 -0.35 0.92 1662.91 1.00 439 330 13 14 TRUE 0.35
colorectal cancer KRAS_12-61 SMAD3 Any mutation 319 44 TMB quintile 5 0.54 -0.03 1.13 1490.56 1.00 298 291 16 28 TRUE 1.13
colorectal cancer KRAS_12-61 SMAD3 Any mutation 35 23 TMB quintile 6 0.22 -0.68 1.08 1328.36 1.00 92 29 17 6 TRUE 0.22
colorectal cancer KRAS_12-61 SMAD3 Any mutation 873 106 TMB overall 0.22 -0.66 1.09 1703.37 1.00 1133 821 54 52 TRUE 0.22
non-small cell lung cancer KRAS_12-61 NTRK3 Any mutation 264 31 TMB quintile 4 1.07 0.38 1.79 1494.35 1.00 489 245 12 19 FALSE 2.46
non-small cell lung cancer KRAS_12-61 NTRK3 Any mutation 458 144 TMB quintile 5 0.12 -0.25 0.48 1501.54 1.00 691 401 87 57 FALSE 0.29
non-small cell lung cancer KRAS_12-61 NTRK3 Any mutation 724 195 TMB overall 0.61 -1.76 3.12 1492.45 1.00 1187 646 117 78 FALSE 0.21
colorectal cancer KRAS_12-61 GRIN2A Any mutation 341 30 TMB quintile 4 -0.35 -1.12 0.37 1255.25 1.00 431 330 19 11 FALSE 0.46
colorectal cancer KRAS_12-61 GRIN2A Any mutation 314 42 TMB quintile 5 -0.43 -1.04 0.16 1408.56 1.00 288 297 25 17 FALSE 0.78
colorectal cancer KRAS_12-61 GRIN2A Any mutation 35 59 TMB quintile 6 -0.24 -1.00 0.49 1239.74 1.00 73 23 47 12 FALSE 0.27
non-small cell lung cancer KRAS_12-61 GRIN2A Any mutation 155 17 TMB quintile 3 0.59 -0.30 1.53 1450.31 1.00 462 147 9 8 FALSE 0.71
non-small cell lung cancer KRAS_12-61 GRIN2A Any mutation 262 39 TMB quintile 4 0.17 -0.40 0.78 1573.86 1.00 477 247 24 15 FALSE 0.24
non-small cell lung cancer KRAS_12-61 GRIN2A Any mutation 458 124 TMB quintile 5 -0.09 -0.50 0.29 1474.23 1.00 692 416 82 42 FALSE 0.19
colorectal cancer KRAS_12-61 GRIN2A Any mutation 690 131 TMB overall -0.32 -1.76 1.10 1281.30 1.00 792 650 91 40 FALSE 0.19
non-small cell lung cancer KRAS_12-61 GRIN2A Any mutation 875 180 TMB overall 0.21 -0.72 1.19 1508.35 1.00 1631 810 115 65 FALSE 0.18
uterine cancer KRAS_12-61 CTCF Any mutation 44 12 TMB quintile 4 -0.22 -1.70 1.04 1178.43 1.00 175 42 10 2 FALSE 0.12
uterine cancer KRAS_12-61 CTCF Any mutation 64 103 TMB quintile 5 0.31 -0.26 0.86 1482.19 1.00 130 36 75 28 FALSE 0.56
uterine cancer KRAS_12-61 CTCF Any mutation 8 48 TMB quintile 6 0.92 -0.49 2.69 1496.93 1.00 26 1 41 7 FALSE 0.59
uterine cancer KRAS_12-61 CTCF Any mutation 116 163 TMB overall 0.34 -1.38 2.21 1609.10 1.00 331 79 126 37 FALSE 0.15
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 83 12 TMB quintile 2 1.64 0.69 2.66 1524.17 1.00 354 75 4 8 TRUE 2.95
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 157 78 TMB quintile 3 1.46 1.00 1.94 1327.84 1.00 435 115 36 42 TRUE 8.80
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 265 161 TMB quintile 4 1.51 1.14 1.86 1642.28 1.00 440 164 60 101 TRUE 37.62
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 458 283 TMB quintile 5 0.34 0.07 0.60 1401.17 1.00 616 338 163 120 TRUE 1.89
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 963 534 TMB overall 1.22 0.25 2.31 1595.59 1.00 1845 692 263 271 TRUE 1.74
colorectal cancer KRAS_12-61 ASXL1 Any mutation 341 15 TMB quintile 4 -0.55 -1.60 0.41 1536.39 1.00 440 336 10 5 TRUE 0.55
colorectal cancer KRAS_12-61 ASXL1 Any mutation 313 30 TMB quintile 5 -0.23 -0.98 0.48 1460.78 1.00 298 299 16 14 TRUE 0.27
colorectal cancer KRAS_12-61 ASXL1 Any mutation 34 57 TMB quintile 6 -1.01 -1.83 -0.17 1546.73 1.00 67 27 50 7 TRUE 1.73
colorectal cancer KRAS_12-61 ASXL1 Any mutation 688 102 TMB overall -0.59 -2.34 1.09 1445.87 1.00 805 662 76 26 TRUE 0.31
colorectal cancer KRAS_12-61 EP300 Any mutation 313 39 TMB quintile 5 -1.11 -1.85 -0.43 1440.39 1.00 286 303 29 10 TRUE 2.61
colorectal cancer KRAS_12-61 EP300 Any mutation 40 72 TMB quintile 6 0.12 -0.56 0.86 1479.33 1.00 71 21 53 19 TRUE 0.14
non-small cell lung cancer KRAS_12-61 EP300 Any mutation 455 77 TMB quintile 5 -0.49 -1.02 0.02 1398.97 1.00 718 434 56 21 TRUE 1.19
uterine cancer KRAS_12-61 EP300 Any mutation 63 39 TMB quintile 5 0.21 -0.61 0.93 1509.17 1.00 175 52 28 11 TRUE 0.23
uterine cancer KRAS_12-61 EP300 Any mutation 10 53 TMB quintile 6 -0.10 -1.29 1.13 1530.85 1.00 28 4 47 6 TRUE 0.06
colorectal cancer KRAS_12-61 EP300 Any mutation 353 111 TMB overall -0.46 -2.81 1.89 1452.27 1.00 357 324 82 29 TRUE 0.16
non-small cell lung cancer KRAS_12-61 EP300 Any mutation 455 77 TMB overall -0.38 -4.22 4.45 1454.79 1.00 718 434 56 21 TRUE 0.07
uterine cancer KRAS_12-61 EP300 Any mutation 73 92 TMB overall 0.06 -2.06 2.49 1311.05 1.00 203 56 75 17 TRUE 0.02
colorectal cancer KRAS_12-61 ERBB4 Any mutation 341 22 TMB quintile 4 0.19 -0.59 0.97 1280.54 1.00 440 330 11 11 TRUE 0.19
colorectal cancer KRAS_12-61 ERBB4 Any mutation 314 45 TMB quintile 5 -0.03 -0.62 0.55 1744.79 1.00 291 292 23 22 TRUE 0.04
colorectal cancer KRAS_12-61 ERBB4 Any mutation 41 61 TMB quintile 6 0.80 0.13 1.49 1393.23 1.00 78 19 39 22 TRUE 1.63
non-small cell lung cancer KRAS_12-61 ERBB4 Any mutation 262 25 TMB quintile 4 -0.24 -1.14 0.59 1550.73 1.00 483 254 17 8 TRUE 0.24
non-small cell lung cancer KRAS_12-61 ERBB4 Any mutation 459 148 TMB quintile 5 -0.56 -0.93 -0.19 1408.33 1.00 680 420 109 39 TRUE 2.37
colorectal cancer KRAS_12-61 ERBB4 Any mutation 696 128 TMB overall 0.31 -1.16 1.84 1243.51 1.00 809 641 73 55 TRUE 0.16
non-small cell lung cancer KRAS_12-61 ERBB4 Any mutation 722 185 TMB overall -0.84 -3.12 1.20 1597.02 1.00 1171 675 138 47 TRUE 0.36
colorectal cancer KRAS_12-61 MED12 Any mutation 342 18 TMB quintile 4 0.16 -0.73 1.09 1395.24 1.00 441 333 9 9 TRUE 0.14
colorectal cancer KRAS_12-61 MED12 Any mutation 313 28 TMB quintile 5 0.10 -0.65 0.85 1540.04 1.00 302 298 13 15 TRUE 0.10
colorectal cancer KRAS_12-61 MED12 Any mutation 38 59 TMB quintile 6 -0.05 -0.81 0.68 1484.78 1.00 71 24 45 14 TRUE 0.05
non-small cell lung cancer KRAS_12-61 MED12 Any mutation 155 23 TMB quintile 3 -0.42 -1.25 0.30 1548.84 1.00 452 151 19 4 TRUE 0.55
non-small cell lung cancer KRAS_12-61 MED12 Any mutation 262 32 TMB quintile 4 -0.36 -1.02 0.26 1380.78 1.00 477 253 23 9 TRUE 0.57
non-small cell lung cancer KRAS_12-61 MED12 Any mutation 458 101 TMB quintile 5 -0.21 -0.62 0.19 1315.75 1.00 706 425 68 33 TRUE 0.51
uterine cancer KRAS_12-61 MED12 Any mutation 13 13 TMB quintile 2 -1.43 -3.79 0.30 1433.88 1.00 119 13 13 0 TRUE 0.76
uterine cancer KRAS_12-61 MED12 Any mutation 26 16 TMB quintile 3 -0.42 -1.93 0.91 1414.21 1.00 201 24 14 2 TRUE 0.25
uterine cancer KRAS_12-61 MED12 Any mutation 44 20 TMB quintile 4 -0.97 -2.37 0.30 1401.30 1.00 167 42 18 2 TRUE 0.79
uterine cancer KRAS_12-61 MED12 Any mutation 62 31 TMB quintile 5 -0.24 -1.18 0.58 1461.25 1.00 180 55 24 7 TRUE 0.23
uterine cancer KRAS_12-61 MED12 Any mutation 8 58 TMB quintile 6 -1.43 -2.99 -0.09 1463.77 1.00 27 6 56 2 TRUE 1.25
colorectal cancer KRAS_12-61 MED12 Any mutation 693 105 TMB overall 0.07 -1.74 1.68 1605.95 1.00 814 655 67 38 TRUE 0.03
non-small cell lung cancer KRAS_12-61 MED12 Any mutation 875 156 TMB overall -0.33 -1.04 0.34 1453.44 1.00 1635 829 110 46 TRUE 0.46
uterine cancer KRAS_12-61 MED12 Any mutation 153 138 TMB overall -0.90 -2.28 0.29 1607.90 1.00 694 140 125 13 TRUE 0.81
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 83 29 TMB quintile 2 0.34 -0.38 0.94 1272.98 1.00 335 77 23 6 FALSE 0.50
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 155 46 TMB quintile 3 0.45 -0.02 0.95 1230.70 1.00 441 140 31 15 FALSE 1.11
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 263 90 TMB quintile 4 0.80 0.42 1.19 1274.33 1.00 457 216 43 47 FALSE 4.33
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 462 200 TMB quintile 5 0.79 0.48 1.06 1409.76 1.00 685 356 94 106 FALSE 7.07
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 963 365 TMB overall 0.59 0.07 1.09 1535.57 1.00 1918 789 191 174 FALSE 1.59
colorectal cancer KRAS_12-61 NF1 Any mutation 341 13 TMB quintile 4 -1.46 -3.09 -0.25 1593.38 1.00 440 339 11 2 TRUE 1.35
colorectal cancer KRAS_12-61 NF1 Any mutation 314 34 TMB quintile 5 -0.44 -1.12 0.20 1453.55 1.00 293 300 20 14 TRUE 0.68
colorectal cancer KRAS_12-61 NF1 Any mutation 38 86 TMB quintile 6 -0.39 -1.14 0.33 1356.42 1.00 67 22 70 16 TRUE 0.51
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 155 25 TMB quintile 3 -0.81 -1.74 0.11 1665.19 1.00 451 151 21 4 TRUE 1.07
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 262 59 TMB quintile 4 -1.19 -1.94 -0.56 1423.47 1.00 457 254 51 8 TRUE 3.15
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 460 216 TMB quintile 5 -0.65 -0.99 -0.34 1324.12 1.00 637 406 162 54 TRUE 3.99
uterine cancer KRAS_12-61 NF1 Any mutation 62 38 TMB quintile 5 -0.86 -1.93 0.11 1454.85 1.00 174 57 33 5 TRUE 1.04
uterine cancer KRAS_12-61 NF1 Any mutation 8 73 TMB quintile 6 -1.02 -2.47 0.39 1413.34 1.00 25 4 69 4 TRUE 0.79
colorectal cancer KRAS_12-61 NF1 Any mutation 693 133 TMB overall -0.73 -2.69 1.04 1584.19 1.00 800 661 101 32 TRUE 0.36
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 877 300 TMB overall -0.88 -1.82 0.08 1655.17 1.00 1545 811 234 66 TRUE 1.21
uterine cancer KRAS_12-61 NF1 Any mutation 70 111 TMB overall -0.86 -3.44 1.87 1454.67 1.00 199 61 102 9 TRUE 0.29
non-small cell lung cancer KRAS_12-61 FLT1 Any mutation 262 21 TMB quintile 4 0.90 0.06 1.78 1401.14 1.00 493 249 8 13 FALSE 1.33
non-small cell lung cancer KRAS_12-61 FLT1 Any mutation 457 99 TMB quintile 5 -0.33 -0.79 0.10 1513.54 1.00 706 428 70 29 FALSE 0.85
non-small cell lung cancer KRAS_12-61 FLT1 Any mutation 719 120 TMB overall 0.25 -1.65 2.34 1484.91 1.00 1199 677 78 42 FALSE 0.10
uterine cancer KRAS_12-61 RASA1 Any mutation 62 25 TMB quintile 5 -0.74 -2.01 0.38 1564.28 1.00 181 58 21 4 FALSE 0.65
uterine cancer KRAS_12-61 RASA1 Any mutation 7 70 TMB quintile 6 -1.89 -3.62 -0.42 1353.46 1.00 24 5 68 2 FALSE 1.72
uterine cancer KRAS_12-61 RASA1 Any mutation 69 95 TMB overall -1.23 -3.94 1.49 1463.26 1.00 205 63 89 6 FALSE 0.42
colorectal cancer KRAS_12-61 EPHA5 Any mutation 341 18 TMB quintile 4 -0.56 -1.53 0.40 1412.65 1.00 438 335 12 6 FALSE 0.63
colorectal cancer KRAS_12-61 EPHA5 Any mutation 314 52 TMB quintile 5 -0.44 -1.05 0.09 1620.58 1.00 284 293 31 21 FALSE 0.88
colorectal cancer KRAS_12-61 EPHA5 Any mutation 37 66 TMB quintile 6 -0.90 -1.76 -0.13 1468.64 1.00 70 28 57 9 FALSE 1.52
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 262 48 TMB quintile 4 0.36 -0.22 0.92 1316.89 1.00 474 241 27 21 FALSE 0.67
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 458 191 TMB quintile 5 0.01 -0.31 0.33 1543.98 1.00 664 387 120 71 FALSE 0.03
colorectal cancer KRAS_12-61 EPHA5 Any mutation 692 136 TMB overall -0.61 -2.10 0.86 1380.56 1.00 792 656 100 36 FALSE 0.38
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 721 250 TMB overall 0.25 -1.45 2.28 1367.42 1.00 1148 628 157 93 FALSE 0.11
colorectal cancer KRAS_12-61 AR Any mutation 341 21 TMB quintile 4 -1.15 -2.20 -0.26 1618.77 1.00 433 337 17 4 TRUE 1.60
colorectal cancer KRAS_12-61 AR Any mutation 314 34 TMB quintile 5 -0.53 -1.23 0.11 1350.74 1.00 293 301 21 13 TRUE 0.93
colorectal cancer KRAS_12-61 AR Any mutation 36 55 TMB quintile 6 0.06 -0.72 0.80 1458.42 1.00 75 22 41 14 TRUE 0.05
non-small cell lung cancer KRAS_12-61 AR Any mutation 262 16 TMB quintile 4 0.12 -0.79 1.05 1249.43 1.00 491 255 9 7 TRUE 0.10
non-small cell lung cancer KRAS_12-61 AR Any mutation 457 77 TMB quintile 5 -0.29 -0.80 0.20 1365.73 1.00 720 434 54 23 TRUE 0.60
colorectal cancer KRAS_12-61 AR Any mutation 691 110 TMB overall -0.52 -1.96 1.04 1596.06 1.00 801 660 79 31 TRUE 0.32
non-small cell lung cancer KRAS_12-61 AR Any mutation 719 93 TMB overall -0.11 -1.64 1.30 1517.66 1.00 1211 689 63 30 TRUE 0.05
colorectal cancer KRAS_12-61 ROS1 Any mutation 341 14 TMB quintile 4 -1.50 -2.94 -0.33 1519.95 1.00 438 339 12 2 TRUE 1.63
colorectal cancer KRAS_12-61 ROS1 Any mutation 313 24 TMB quintile 5 -0.98 -1.88 -0.16 1484.01 1.00 296 306 17 7 TRUE 1.62
colorectal cancer KRAS_12-61 ROS1 Any mutation 40 61 TMB quintile 6 -0.19 -0.90 0.50 1593.15 1.00 77 26 47 14 TRUE 0.21
non-small cell lung cancer KRAS_12-61 ROS1 Any mutation 262 13 TMB quintile 4 -1.75 -3.47 -0.49 1415.74 1.00 488 261 12 1 TRUE 1.58
non-small cell lung cancer KRAS_12-61 ROS1 Any mutation 455 80 TMB quintile 5 -1.12 -1.70 -0.56 1522.83 1.00 707 441 66 14 TRUE 3.86
colorectal cancer KRAS_12-61 ROS1 Any mutation 694 99 TMB overall -0.87 -2.52 0.89 1529.77 1.00 811 671 76 23 TRUE 0.52
non-small cell lung cancer KRAS_12-61 ROS1 Any mutation 717 93 TMB overall -1.39 -3.32 0.39 1652.17 1.00 1195 702 78 15 TRUE 0.92
colorectal cancer KRAS_12-61 PIK3CG Any mutation 341 16 TMB quintile 4 -0.62 -1.59 0.32 1470.63 1.00 439 336 11 5 FALSE 0.69
colorectal cancer KRAS_12-61 PIK3CG Any mutation 313 38 TMB quintile 5 -0.36 -0.98 0.23 1502.96 1.00 291 297 22 16 FALSE 0.59
colorectal cancer KRAS_12-61 PIK3CG Any mutation 38 45 TMB quintile 6 -0.21 -1.08 0.57 1505.90 1.00 83 28 35 10 FALSE 0.22
non-small cell lung cancer KRAS_12-61 PIK3CG Any mutation 262 16 TMB quintile 4 -0.03 -1.01 0.92 1510.71 1.00 490 256 10 6 FALSE 0.03
non-small cell lung cancer KRAS_12-61 PIK3CG Any mutation 458 150 TMB quintile 5 -0.23 -0.62 0.14 1368.81 1.00 681 410 102 48 FALSE 0.64
colorectal cancer KRAS_12-61 PIK3CG Any mutation 692 99 TMB overall -0.38 -1.76 1.06 1264.28 1.00 813 661 68 31 FALSE 0.22
non-small cell lung cancer KRAS_12-61 PIK3CG Any mutation 720 166 TMB overall -0.14 -2.06 1.71 1489.69 1.00 1171 666 112 54 FALSE 0.06
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 83 200 TMB quintile 2 -5.30 -8.15 -3.40 1465.96 1.00 180 83 200 0 TRUE 4.88
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 155 287 TMB quintile 3 -5.61 -8.23 -3.95 1456.58 1.00 241 155 287 0 TRUE 6.16
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 262 256 TMB quintile 4 -4.03 -5.03 -3.17 1481.40 1.00 312 258 252 4 TRUE 16.40
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 455 175 TMB quintile 5 -1.84 -2.42 -1.35 1596.54 1.00 652 436 156 19 TRUE 10.76
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 955 918 TMB overall -4.15 -6.00 -2.69 1338.84 1.00 1385 932 895 23 TRUE 6.22
colorectal cancer KRAS_12-61 ARID1B Any mutation 341 13 TMB quintile 4 -0.76 -2.01 0.30 1573.16 1.00 442 337 9 4 TRUE 0.71
colorectal cancer KRAS_12-61 ARID1B Any mutation 314 46 TMB quintile 5 -1.14 -1.84 -0.48 1342.03 1.00 281 302 34 12 TRUE 2.99
colorectal cancer KRAS_12-61 ARID1B Any mutation 34 79 TMB quintile 6 -1.07 -1.87 -0.27 1443.33 1.00 57 24 69 10 TRUE 2.12
non-small cell lung cancer KRAS_12-61 ARID1B Any mutation 155 11 TMB quintile 3 -0.62 -1.81 0.40 1467.77 1.00 462 153 9 2 TRUE 0.58
non-small cell lung cancer KRAS_12-61 ARID1B Any mutation 262 16 TMB quintile 4 -0.97 -2.20 -0.01 1536.70 1.00 487 260 14 2 TRUE 1.08
non-small cell lung cancer KRAS_12-61 ARID1B Any mutation 456 77 TMB quintile 5 -0.24 -0.74 0.24 1399.91 1.00 720 431 52 25 TRUE 0.50
uterine cancer KRAS_12-61 ARID1B Any mutation 66 59 TMB quintile 5 0.24 -0.43 0.88 1356.27 1.00 163 49 42 17 TRUE 0.34
uterine cancer KRAS_12-61 ARID1B Any mutation 7 48 TMB quintile 6 -0.18 -1.62 1.17 1461.18 1.00 27 3 44 4 TRUE 0.10
colorectal cancer KRAS_12-61 ARID1B Any mutation 689 138 TMB overall -0.94 -2.58 0.78 1458.29 1.00 780 663 112 26 TRUE 0.55
non-small cell lung cancer KRAS_12-61 ARID1B Any mutation 873 104 TMB overall -0.63 -1.77 0.36 1685.88 1.00 1669 844 75 29 TRUE 0.61
uterine cancer KRAS_12-61 ARID1B Any mutation 73 107 TMB overall 0.03 -2.23 2.38 1512.27 1.00 190 52 86 21 TRUE 0.01
non-small cell lung cancer KRAS_12-61 MET Any mutation 83 21 TMB quintile 2 -0.89 -1.91 -0.04 1568.32 1.00 340 81 19 2 TRUE 1.19
non-small cell lung cancer KRAS_12-61 MET Any mutation 155 30 TMB quintile 3 -0.99 -1.94 -0.19 1674.63 1.00 450 152 27 3 TRUE 1.55
non-small cell lung cancer KRAS_12-61 MET Any mutation 262 34 TMB quintile 4 -1.37 -2.49 -0.54 1487.86 1.00 474 260 32 2 TRUE 2.28
non-small cell lung cancer KRAS_12-61 MET Any mutation 454 47 TMB quintile 5 -0.18 -0.81 0.40 1371.18 1.00 743 435 28 19 TRUE 0.26
non-small cell lung cancer KRAS_12-61 MET Any mutation 954 132 TMB overall -0.85 -1.74 -0.12 1668.12 1.00 2007 928 106 26 TRUE 1.47
colorectal cancer KRAS_12-61 BRAF Any mutation 175 27 TMB quintile 3 -1.96 -3.10 -0.86 1593.05 1.00 288 172 24 3 TRUE 3.36
colorectal cancer KRAS_12-61 BRAF Any mutation 341 60 TMB quintile 4 -2.32 -3.22 -1.52 1498.95 1.00 395 336 55 5 TRUE 7.12
colorectal cancer KRAS_12-61 BRAF Any mutation 314 104 TMB quintile 5 -2.85 -3.60 -2.18 1562.06 1.00 218 307 97 7 TRUE 15.03
colorectal cancer KRAS_12-61 BRAF Any mutation 34 59 TMB quintile 6 -2.07 -3.10 -1.17 1390.74 1.00 62 30 55 4 TRUE 4.31
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 83 11 TMB quintile 2 -1.68 -3.38 -0.36 1231.65 1.00 347 83 11 0 TRUE 1.45
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 155 13 TMB quintile 3 -1.83 -3.68 -0.52 1697.87 1.00 458 155 13 0 TRUE 1.67
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 262 46 TMB quintile 4 -1.20 -1.96 -0.48 1502.31 1.00 462 255 39 7 TRUE 2.78
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 454 101 TMB quintile 5 -0.87 -1.36 -0.38 1248.60 1.00 692 432 79 22 TRUE 3.37
colorectal cancer KRAS_12-61 BRAF Any mutation 864 250 TMB overall -2.29 -3.30 -1.23 1560.23 1.00 963 845 231 19 TRUE 4.99
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 954 171 TMB overall -1.38 -2.55 -0.45 1599.38 1.00 1959 925 142 29 TRUE 2.03
colorectal cancer KRAS_12-61 B2M Any mutation 301 50 TMB quintile 5 -0.79 -1.43 -0.21 1419.69 1.00 273 285 34 16 FALSE 2.04
colorectal cancer KRAS_12-61 B2M Any mutation 44 79 TMB quintile 6 0.24 -0.44 0.92 1522.34 1.00 68 21 56 23 FALSE 0.32
colorectal cancer KRAS_12-61 B2M Any mutation 345 129 TMB overall -0.24 -2.41 2.01 1588.38 1.00 341 306 90 39 FALSE 0.08
colorectal cancer KRAS_12-61 CARD11 Any mutation 341 28 TMB quintile 4 -0.10 -0.79 0.66 1480.34 1.00 434 329 16 12 FALSE 0.10
colorectal cancer KRAS_12-61 CARD11 Any mutation 314 43 TMB quintile 5 -0.34 -0.93 0.27 1590.76 1.00 288 296 25 18 FALSE 0.57
colorectal cancer KRAS_12-61 CARD11 Any mutation 38 52 TMB quintile 6 0.41 -0.33 1.12 1296.07 1.00 79 22 36 16 FALSE 0.58
non-small cell lung cancer KRAS_12-61 CARD11 Any mutation 262 18 TMB quintile 4 0.05 -0.80 0.92 1428.84 1.00 489 255 11 7 FALSE 0.04
non-small cell lung cancer KRAS_12-61 CARD11 Any mutation 457 97 TMB quintile 5 0.02 -0.41 0.41 1426.90 1.00 711 421 61 36 FALSE 0.03
colorectal cancer KRAS_12-61 CARD11 Any mutation 693 123 TMB overall -0.01 -1.39 1.37 1268.36 1.00 801 647 77 46 FALSE 0.00
non-small cell lung cancer KRAS_12-61 CARD11 Any mutation 719 115 TMB overall 0.04 -1.53 1.51 1481.08 1.00 1200 676 72 43 FALSE 0.02
non-small cell lung cancer KRAS_12-61 INPP4B Any mutation 262 17 TMB quintile 4 0.41 -0.45 1.26 1425.42 1.00 491 254 9 8 FALSE 0.45
non-small cell lung cancer KRAS_12-61 INPP4B Any mutation 458 87 TMB quintile 5 0.52 0.07 0.94 1587.98 1.00 729 416 45 42 FALSE 1.69
non-small cell lung cancer KRAS_12-61 INPP4B Any mutation 720 104 TMB overall 0.44 -0.94 1.69 1344.34 1.00 1220 670 54 50 FALSE 0.31
non-small cell lung cancer KRAS_12-61 NFE2L2 Any mutation 262 31 TMB quintile 4 -0.96 -1.69 -0.22 1368.93 1.00 481 256 25 6 FALSE 2.16
non-small cell lung cancer KRAS_12-61 NFE2L2 Any mutation 455 83 TMB quintile 5 -1.00 -1.58 -0.48 1383.33 1.00 707 440 68 15 FALSE 3.65
non-small cell lung cancer KRAS_12-61 NFE2L2 Any mutation 717 114 TMB overall -0.95 -1.81 0.08 1461.60 1.00 1188 696 93 21 FALSE 1.48
colorectal cancer KRAS_12-61 SOX9 Any mutation 175 17 TMB quintile 3 0.08 -0.78 0.91 1623.62 1.00 302 168 10 7 FALSE 0.07
colorectal cancer KRAS_12-61 SOX9 Any mutation 345 85 TMB quintile 4 0.25 -0.17 0.66 1410.14 1.00 407 303 43 42 FALSE 0.61
colorectal cancer KRAS_12-61 SOX9 Any mutation 320 107 TMB quintile 5 0.18 -0.24 0.58 1564.57 1.00 268 263 50 57 FALSE 0.41
colorectal cancer KRAS_12-61 SOX9 Any mutation 37 50 TMB quintile 6 0.50 -0.19 1.20 1488.46 1.00 79 21 34 16 FALSE 0.81
colorectal cancer KRAS_12-61 SOX9 Any mutation 877 259 TMB overall 0.25 -0.63 1.12 1539.54 1.00 1056 755 137 122 FALSE 0.24
colorectal cancer KRAS_12-61 SMAD2 Any mutation 341 29 TMB quintile 4 0.23 -0.41 0.89 1508.82 1.00 436 327 15 14 TRUE 0.32
colorectal cancer KRAS_12-61 SMAD2 Any mutation 317 53 TMB quintile 5 0.60 0.07 1.12 1368.44 1.00 297 283 19 34 TRUE 1.58
colorectal cancer KRAS_12-61 SMAD2 Any mutation 35 16 TMB quintile 6 0.63 -0.28 1.50 1537.59 1.00 100 29 10 6 TRUE 0.76
colorectal cancer KRAS_12-61 SMAD2 Any mutation 693 98 TMB overall 0.48 -0.50 1.40 1595.61 1.00 833 639 44 54 TRUE 0.49
non-small cell lung cancer KRAS_12-61 GLI1 Any mutation 245 16 TMB quintile 4 0.37 -0.50 1.28 1531.13 1.00 429 237 8 8 FALSE 0.39
non-small cell lung cancer KRAS_12-61 GLI1 Any mutation 417 77 TMB quintile 5 0.27 -0.22 0.74 1496.42 1.00 646 384 44 33 FALSE 0.60
non-small cell lung cancer KRAS_12-61 GLI1 Any mutation 662 93 TMB overall 0.34 -1.01 2.01 1526.49 1.00 1075 621 52 41 FALSE 0.20
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 310 14 TMB quintile 4 0.11 -0.96 1.20 1466.57 1.00 403 303 7 7 FALSE 0.08
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 290 63 TMB quintile 5 -0.32 -0.83 0.19 1516.45 1.00 259 263 36 27 FALSE 0.63
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 41 143 TMB quintile 6 -0.33 -1.04 0.43 1426.35 1.00 37 13 115 28 FALSE 0.43
non-small cell lung cancer KRAS_12-61 ZFHX3 Any mutation 144 13 TMB quintile 3 -0.90 -2.38 0.16 1629.15 1.00 414 143 12 1 FALSE 0.81
non-small cell lung cancer KRAS_12-61 ZFHX3 Any mutation 244 30 TMB quintile 4 -0.37 -1.09 0.31 1187.38 1.00 414 235 21 9 FALSE 0.52
non-small cell lung cancer KRAS_12-61 ZFHX3 Any mutation 417 112 TMB quintile 5 -0.22 -0.63 0.17 1471.94 1.00 617 380 75 37 FALSE 0.55
uterine cancer KRAS_12-61 ZFHX3 Any mutation 40 13 TMB quintile 4 -0.02 -1.41 1.18 1441.50 1.00 155 37 10 3 FALSE 0.01
uterine cancer KRAS_12-61 ZFHX3 Any mutation 64 105 TMB quintile 5 0.19 -0.40 0.75 1207.59 1.00 130 37 78 27 FALSE 0.28
uterine cancer KRAS_12-61 ZFHX3 Any mutation 13 92 TMB quintile 6 -0.44 -1.62 0.73 1511.74 1.00 21 4 83 9 FALSE 0.33
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 641 220 TMB overall -0.14 -2.12 1.92 1255.55 1.00 699 579 158 62 FALSE 0.05
non-small cell lung cancer KRAS_12-61 ZFHX3 Any mutation 805 155 TMB overall -0.49 -1.51 0.41 1468.29 1.00 1445 758 108 47 FALSE 0.50
uterine cancer KRAS_12-61 ZFHX3 Any mutation 117 210 TMB overall -0.07 -2.08 1.84 1689.06 1.00 306 78 171 39 FALSE 0.03
colorectal cancer KRAS_12-61 MGA Any mutation 310 15 TMB quintile 4 -0.79 -1.96 0.22 1226.69 1.00 400 306 11 4 FALSE 0.83
colorectal cancer KRAS_12-61 MGA Any mutation 290 46 TMB quintile 5 -0.12 -0.70 0.48 1465.08 1.00 265 268 24 22 FALSE 0.17
colorectal cancer KRAS_12-61 MGA Any mutation 35 58 TMB quintile 6 -0.30 -1.09 0.46 1272.78 1.00 65 23 46 12 FALSE 0.35
non-small cell lung cancer KRAS_12-61 MGA Any mutation 144 14 TMB quintile 3 0.18 -0.77 1.16 1340.77 1.00 418 139 9 5 FALSE 0.15
non-small cell lung cancer KRAS_12-61 MGA Any mutation 244 24 TMB quintile 4 -0.12 -0.91 0.67 1375.73 1.00 419 236 16 8 FALSE 0.12
non-small cell lung cancer KRAS_12-61 MGA Any mutation 419 140 TMB quintile 5 -0.01 -0.36 0.34 1549.30 1.00 612 368 89 51 FALSE 0.03
uterine cancer KRAS_12-61 MGA Any mutation 58 24 TMB quintile 5 -0.50 -1.74 0.52 1360.97 1.00 173 54 20 4 FALSE 0.42
uterine cancer KRAS_12-61 MGA Any mutation 13 82 TMB quintile 6 1.16 -0.40 3.40 1077.73 1.00 23 1 70 12 FALSE 0.67
colorectal cancer KRAS_12-61 MGA Any mutation 635 119 TMB overall -0.40 -1.97 1.37 1506.61 1.00 730 597 81 38 FALSE 0.20
non-small cell lung cancer KRAS_12-61 MGA Any mutation 807 178 TMB overall 0.02 -0.99 1.11 1319.05 1.00 1449 743 114 64 FALSE 0.01
uterine cancer KRAS_12-61 MGA Any mutation 71 106 TMB overall 0.26 -2.73 3.39 1507.28 1.00 196 55 90 16 FALSE 0.06
colorectal cancer KRAS_12-61 KMT2B Any mutation 163 54 TMB quintile 5 -0.04 -0.63 0.54 1515.18 1.00 143 137 28 26 FALSE 0.05
colorectal cancer KRAS_12-61 KMT2B Any mutation 24 115 TMB quintile 6 1.43 -0.09 3.53 1399.35 1.00 21 1 92 23 FALSE 0.91
uterine cancer KRAS_12-61 KMT2B Any mutation 55 95 TMB quintile 5 0.35 -0.25 0.95 1510.03 1.00 99 28 68 27 FALSE 0.57
uterine cancer KRAS_12-61 KMT2B Any mutation 7 67 TMB quintile 6 1.18 -0.87 4.88 1390.95 1.00 10 0 60 7 FALSE 0.37
colorectal cancer KRAS_12-61 KMT2B Any mutation 187 169 TMB overall 0.55 -2.80 3.83 1511.06 1.00 164 138 120 49 FALSE 0.13
uterine cancer KRAS_12-61 KMT2B Any mutation 62 162 TMB overall 0.70 -1.89 3.96 1535.70 1.00 109 28 128 34 FALSE 0.20
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 162 35 TMB quintile 3 0.20 -0.48 0.84 1570.36 1.00 259 147 20 15 FALSE 0.26
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 314 79 TMB quintile 4 0.28 -0.17 0.74 1653.62 1.00 371 274 39 40 FALSE 0.67
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 295 108 TMB quintile 5 -0.09 -0.48 0.32 1305.08 1.00 236 243 56 52 FALSE 0.17
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 34 70 TMB quintile 6 0.22 -0.46 0.92 1554.18 1.00 58 16 52 18 FALSE 0.26
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 805 292 TMB overall 0.15 -0.77 1.10 1559.03 1.00 924 680 167 125 FALSE 0.13
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 302 11 TMB quintile 4 0.21 -0.98 1.45 1665.05 1.00 395 296 5 6 FALSE 0.13
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 272 43 TMB quintile 5 -1.39 -2.15 -0.65 1563.46 1.00 238 263 34 9 FALSE 3.46
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 38 86 TMB quintile 6 0.07 -0.65 0.75 1775.07 1.00 58 17 65 21 FALSE 0.07
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 612 140 TMB overall -0.31 -2.24 1.75 1326.89 1.00 691 576 104 36 FALSE 0.12
colorectal cancer KRAS_12-61 POLD1 Any mutation 291 20 TMB quintile 5 -0.10 -0.98 0.80 1446.83 1.00 280 281 10 10 TRUE 0.08
colorectal cancer KRAS_12-61 POLD1 Any mutation 34 83 TMB quintile 6 -0.60 -1.40 0.18 1332.14 1.00 53 20 69 14 TRUE 0.87
colorectal cancer KRAS_12-61 POLD1 Any mutation 325 103 TMB overall -0.29 -3.14 2.77 1621.37 1.00 333 301 79 24 TRUE 0.08
non-small cell lung cancer KRAS_12-61 PREX2 Any mutation 137 14 TMB quintile 4 -0.30 -1.33 0.65 1529.49 1.00 213 132 9 5 FALSE 0.26
non-small cell lung cancer KRAS_12-61 PREX2 Any mutation 235 84 TMB quintile 5 -0.38 -0.86 0.09 1267.54 1.00 334 210 59 25 FALSE 0.89
non-small cell lung cancer KRAS_12-61 PREX2 Any mutation 372 98 TMB overall -0.37 -1.94 1.14 1323.63 1.00 547 342 68 30 FALSE 0.20
colorectal cancer KRAS_12-61 AMER1 Any mutation 175 13 TMB quintile 3 0.80 -0.11 1.75 1377.40 1.00 307 167 5 8 FALSE 0.98
colorectal cancer KRAS_12-61 AMER1 Any mutation 341 38 TMB quintile 4 0.69 0.06 1.34 1427.81 1.00 437 318 15 23 FALSE 1.44
colorectal cancer KRAS_12-61 AMER1 Any mutation 313 62 TMB quintile 5 0.54 0.04 1.07 1600.28 1.00 289 275 24 38 FALSE 1.37
colorectal cancer KRAS_12-61 AMER1 Any mutation 40 55 TMB quintile 6 0.81 0.13 1.51 1344.33 1.00 78 20 35 20 FALSE 1.61
non-small cell lung cancer KRAS_12-61 AMER1 Any mutation 262 18 TMB quintile 4 1.03 0.07 2.06 1459.23 1.00 493 251 7 11 FALSE 1.42
non-small cell lung cancer KRAS_12-61 AMER1 Any mutation 459 107 TMB quintile 5 0.50 0.10 0.89 1446.85 1.00 720 407 55 52 FALSE 1.92
colorectal cancer KRAS_12-61 AMER1 Any mutation 869 168 TMB overall 0.70 -0.37 1.84 1486.11 1.00 1111 780 79 89 FALSE 0.66
non-small cell lung cancer KRAS_12-61 AMER1 Any mutation 722 142 TMB overall 0.70 -1.69 3.42 1508.19 1.00 1223 658 78 64 FALSE 0.24
non-small cell lung cancer KRAS_12-61 EPHA7 Any mutation 244 14 TMB quintile 4 -0.23 -1.23 0.80 1544.41 1.00 425 239 9 5 FALSE 0.19
non-small cell lung cancer KRAS_12-61 EPHA7 Any mutation 416 101 TMB quintile 5 -0.36 -0.82 0.07 1443.37 1.00 623 386 71 30 FALSE 0.90
non-small cell lung cancer KRAS_12-61 EPHA7 Any mutation 660 115 TMB overall -0.28 -2.00 1.61 1499.60 1.00 1048 625 80 35 FALSE 0.13
uterine cancer KRAS_12-61 INPPL1 Any mutation 53 82 TMB quintile 5 0.33 -0.30 0.94 1508.78 1.00 97 29 58 24 FALSE 0.52
uterine cancer KRAS_12-61 INPPL1 Any mutation 8 40 TMB quintile 6 0.31 -0.94 1.79 1405.12 1.00 18 2 34 6 FALSE 0.19
uterine cancer KRAS_12-61 INPPL1 Any mutation 61 122 TMB overall 0.34 -1.33 2.19 1481.64 1.00 115 31 92 30 FALSE 0.16
melanoma NRAS_12-61 SPEN Any mutation 150 55 TMB quintile 5 -0.18 -0.79 0.39 1624.84 1.00 218 131 36 19 FALSE 0.26
melanoma NRAS_12-61 SPEN Any mutation 6 56 TMB quintile 6 -1.12 -2.80 0.44 1477.74 1.00 34 4 54 2 FALSE 0.72
melanoma NRAS_12-61 SPEN Any mutation 156 111 TMB overall -0.57 -3.30 2.05 1636.82 1.00 252 135 90 21 FALSE 0.18
melanoma NRAS_12-61 KMT2C Any mutation 143 85 TMB quintile 5 -0.39 -0.92 0.10 1497.26 1.00 186 117 59 26 FALSE 0.85
melanoma NRAS_12-61 KMT2C Any mutation 7 54 TMB quintile 6 -1.04 -2.53 0.31 1533.13 1.00 24 4 51 3 FALSE 0.82
melanoma NRAS_12-61 KMT2C Any mutation 150 139 TMB overall -0.65 -3.01 1.88 1578.54 1.00 210 121 110 29 FALSE 0.22
melanoma NRAS_12-61 TP53 Any mutation 14 14 TMB quintile 3 -1.38 -3.98 0.27 1306.19 1.00 84 14 14 0 TRUE 0.70
melanoma NRAS_12-61 TP53 Any mutation 19 16 TMB quintile 4 0.10 -1.11 1.24 1451.24 1.00 74 15 12 4 TRUE 0.06
melanoma NRAS_12-61 TP53 Any mutation 151 119 TMB quintile 5 -0.26 -0.69 0.19 1146.54 1.00 178 112 80 39 TRUE 0.60
melanoma NRAS_12-61 TP53 Any mutation 7 52 TMB quintile 6 -0.45 -1.74 0.83 1435.36 1.00 26 3 48 4 TRUE 0.31
melanoma NRAS_12-61 TP53 Any mutation 191 201 TMB overall -0.48 -1.85 0.85 1310.19 1.00 362 144 154 47 TRUE 0.32
melanoma NRAS_12-61 ATRX Any mutation 148 58 TMB quintile 5 -0.34 -0.94 0.26 1363.85 1.00 221 130 40 18 TRUE 0.57
melanoma NRAS_12-61 ATRX Any mutation 6 30 TMB quintile 6 -2.83 -7.85 -0.28 1156.20 1.00 48 6 30 0 TRUE 0.76
melanoma NRAS_12-61 ATRX Any mutation 154 88 TMB overall -1.45 -4.94 1.28 1269.60 1.00 269 136 70 18 TRUE 0.46
melanoma NRAS_12-61 PTPRD Any mutation 156 147 TMB quintile 5 -0.30 -0.73 0.12 1501.85 1.00 173 109 100 47 FALSE 0.76
melanoma NRAS_12-61 PTPRD Any mutation 11 115 TMB quintile 6 0.32 -1.15 2.38 1336.06 1.00 20 1 105 10 FALSE 0.14
melanoma NRAS_12-61 PTPRD Any mutation 167 262 TMB overall 0.02 -2.50 2.96 1486.08 1.00 193 110 205 57 FALSE 0.00
melanoma NRAS_12-61 PIK3C2G Any mutation 145 99 TMB quintile 5 0.01 -0.47 0.47 1551.96 1.00 185 108 62 37 FALSE 0.02
melanoma NRAS_12-61 PIK3C2G Any mutation 9 85 TMB quintile 6 -0.24 -1.60 1.37 1519.90 1.00 18 2 78 7 FALSE 0.12
melanoma NRAS_12-61 PIK3C2G Any mutation 154 184 TMB overall -0.10 -2.74 2.77 1398.98 1.00 203 110 140 44 FALSE 0.03
melanoma NRAS_12-61 PTPRT Any mutation 159 200 TMB quintile 5 -0.07 -0.45 0.31 1592.07 1.00 158 90 131 69 FALSE 0.14
melanoma NRAS_12-61 PTPRT Any mutation 13 153 TMB quintile 6 1.40 -0.98 5.86 1406.31 1.00 13 0 140 13 FALSE 0.37
melanoma NRAS_12-61 PTPRT Any mutation 172 353 TMB overall 0.54 -2.60 4.72 1371.37 1.00 171 90 271 82 FALSE 0.12
melanoma NRAS_12-61 ALK Any mutation 148 76 TMB quintile 5 -0.26 -0.86 0.26 1502.68 1.00 205 124 52 24 TRUE 0.47
melanoma NRAS_12-61 ALK Any mutation 7 51 TMB quintile 6 0.32 -1.16 1.87 1526.33 1.00 33 2 46 5 TRUE 0.17
melanoma NRAS_12-61 ALK Any mutation 155 127 TMB overall -0.02 -2.32 2.60 1455.46 1.00 238 126 98 29 TRUE 0.01
melanoma NRAS_12-61 IKZF1 Any mutation 148 57 TMB quintile 5 -0.29 -0.87 0.27 1312.61 1.00 219 130 39 18 TRUE 0.48
melanoma NRAS_12-61 IKZF1 Any mutation 7 44 TMB quintile 6 -0.52 -2.07 0.82 1578.36 1.00 38 4 41 3 TRUE 0.32
melanoma NRAS_12-61 IKZF1 Any mutation 155 101 TMB overall -0.40 -2.77 2.06 1430.70 1.00 257 134 80 21 TRUE 0.13
melanoma NRAS_12-61 FAT1 Any mutation 149 86 TMB quintile 5 -0.29 -0.80 0.20 1470.18 1.00 200 122 59 27 FALSE 0.58
melanoma NRAS_12-61 FAT1 Any mutation 8 50 TMB quintile 6 0.54 -0.92 2.21 1503.78 1.00 37 2 44 6 FALSE 0.32
melanoma NRAS_12-61 FAT1 Any mutation 157 136 TMB overall 0.06 -2.49 2.90 1576.16 1.00 237 124 103 33 FALSE 0.02
melanoma NRAS_12-61 KMT2A Any mutation 149 69 TMB quintile 5 -0.11 -0.66 0.46 1609.63 1.00 216 125 45 24 FALSE 0.16
melanoma NRAS_12-61 KMT2A Any mutation 6 62 TMB quintile 6 -0.12 -1.64 1.57 1455.67 1.00 30 2 58 4 FALSE 0.06
melanoma NRAS_12-61 KMT2A Any mutation 155 131 TMB overall -0.14 -2.90 2.75 1521.02 1.00 246 127 103 28 FALSE 0.04
melanoma NRAS_12-61 PAK7 Any mutation 147 135 TMB quintile 5 -0.45 -0.87 -0.01 1300.20 1.00 158 106 94 41 FALSE 1.38
melanoma NRAS_12-61 PAK7 Any mutation 8 75 TMB quintile 6 -1.34 -2.75 0.01 1379.76 1.00 17 4 71 4 FALSE 1.27
melanoma NRAS_12-61 PAK7 Any mutation 155 210 TMB overall -0.85 -3.05 1.64 1464.38 1.00 175 110 165 45 FALSE 0.34
melanoma NRAS_12-61 TERT Any mutation 16 17 TMB quintile 2 1.74 0.58 2.84 1576.65 1.00 98 9 10 7 TRUE 2.61
melanoma NRAS_12-61 TERT Any mutation 14 29 TMB quintile 3 0.54 -0.66 1.70 1521.98 1.00 74 9 24 5 TRUE 0.45
melanoma NRAS_12-61 TERT Any mutation 21 57 TMB quintile 4 0.99 0.06 1.96 1385.17 1.00 44 6 42 15 TRUE 1.36
melanoma NRAS_12-61 TERT Any mutation 164 396 TMB quintile 5 0.45 -0.15 1.07 1458.43 1.00 40 17 249 147 TRUE 0.85
melanoma NRAS_12-61 TERT Any mutation 11 106 TMB quintile 6 1.05 -0.57 3.06 1513.40 1.00 12 0 95 11 TRUE 0.61
melanoma NRAS_12-61 TERT Any mutation 226 605 TMB overall 0.94 -0.35 2.32 1446.59 1.00 268 41 420 185 TRUE 0.76
melanoma NRAS_12-61 NOTCH3 Any mutation 147 67 TMB quintile 5 -0.42 -0.98 0.13 1365.20 1.00 208 127 47 20 TRUE 0.84
melanoma NRAS_12-61 NOTCH3 Any mutation 6 57 TMB quintile 6 -2.05 -4.34 -0.33 1654.07 1.00 30 5 56 1 TRUE 1.39
melanoma NRAS_12-61 NOTCH3 Any mutation 153 124 TMB overall -1.12 -3.85 1.68 1500.00 1.00 238 132 103 21 TRUE 0.39
melanoma NRAS_12-61 NOTCH4 Any mutation 143 81 TMB quintile 5 -0.21 -0.74 0.31 1539.43 1.00 191 116 54 27 TRUE 0.37
melanoma NRAS_12-61 NOTCH4 Any mutation 9 64 TMB quintile 6 0.09 -1.28 1.61 1403.00 1.00 20 2 57 7 TRUE 0.04
melanoma NRAS_12-61 NOTCH4 Any mutation 152 145 TMB overall -0.05 -2.52 2.81 1450.13 1.00 211 118 111 34 TRUE 0.01
melanoma NRAS_12-61 CDKN2A Any mutation 151 80 TMB quintile 5 -0.03 -0.54 0.46 1397.37 1.00 205 121 50 30 TRUE 0.04
melanoma NRAS_12-61 CDKN2A Any mutation 6 34 TMB quintile 6 -0.67 -2.24 0.80 1527.89 1.00 34 4 32 2 TRUE 0.41
melanoma NRAS_12-61 CDKN2A Any mutation 157 114 TMB overall -0.35 -2.77 1.73 1587.94 1.00 239 125 82 32 TRUE 0.11
melanoma NRAS_12-61 KMT2D Any mutation 157 112 TMB quintile 5 0.16 -0.28 0.60 1373.20 1.00 199 112 67 45 FALSE 0.32
melanoma NRAS_12-61 KMT2D Any mutation 11 91 TMB quintile 6 0.86 -0.58 2.75 1164.70 1.00 27 1 81 10 FALSE 0.47
melanoma NRAS_12-61 KMT2D Any mutation 168 203 TMB overall 0.44 -2.37 3.42 1295.50 1.00 226 113 148 55 FALSE 0.13
colorectal cancer NRAS_12-61 APC Any mutation 19 428 TMB quintile 3 0.31 -0.65 1.26 1406.05 1.00 153 5 414 14 TRUE 0.27
colorectal cancer NRAS_12-61 APC Any mutation 52 966 TMB quintile 4 1.43 0.43 2.77 1248.86 1.00 151 1 915 51 TRUE 1.78
colorectal cancer NRAS_12-61 APC Any mutation 47 822 TMB quintile 5 0.82 -0.04 1.78 1556.98 1.00 147 4 779 43 TRUE 1.10
melanoma NRAS_12-61 APC Any mutation 147 67 TMB quintile 5 -0.62 -1.22 -0.03 1527.09 1.00 213 130 50 17 TRUE 1.41
melanoma NRAS_12-61 APC Any mutation 6 50 TMB quintile 6 -0.49 -2.00 1.17 1475.71 1.00 35 3 47 3 TRUE 0.26
colorectal cancer NRAS_12-61 APC Any mutation 119 2519 TMB overall 0.36 -0.94 1.56 1576.44 1.00 565 11 2411 108 TRUE 0.24
melanoma NRAS_12-61 APC Any mutation 153 117 TMB overall -0.53 -2.88 1.84 1478.96 1.00 248 133 97 20 TRUE 0.18
melanoma NRAS_12-61 ARID2 Any mutation 154 83 TMB quintile 5 0.05 -0.40 0.54 1313.73 1.00 211 122 51 32 FALSE 0.08
melanoma NRAS_12-61 ARID2 Any mutation 6 53 TMB quintile 6 -0.87 -2.60 0.58 1580.34 1.00 43 4 51 2 FALSE 0.57
melanoma NRAS_12-61 ARID2 Any mutation 160 136 TMB overall -0.37 -2.81 2.07 1465.68 1.00 254 126 102 34 FALSE 0.12
melanoma NRAS_12-61 EPHA3 Any mutation 149 57 TMB quintile 5 0.49 -0.06 1.08 1507.82 1.00 227 122 30 27 FALSE 1.05
melanoma NRAS_12-61 EPHA3 Any mutation 6 45 TMB quintile 6 0.39 -1.03 2.03 1407.34 1.00 36 2 41 4 FALSE 0.20
melanoma NRAS_12-61 EPHA3 Any mutation 155 102 TMB overall 0.39 -2.29 2.98 1377.98 1.00 263 124 71 31 FALSE 0.12
melanoma NRAS_12-61 KDR Any mutation 147 64 TMB quintile 5 -0.07 -0.62 0.48 1577.71 1.00 212 124 41 23 TRUE 0.09
melanoma NRAS_12-61 KDR Any mutation 8 62 TMB quintile 6 -0.24 -1.62 1.13 1165.92 1.00 28 3 57 5 TRUE 0.14
melanoma NRAS_12-61 KDR Any mutation 155 126 TMB overall -0.17 -2.71 2.42 1600.96 1.00 240 127 98 28 TRUE 0.05
melanoma NRAS_12-61 NTRK3 Any mutation 151 58 TMB quintile 5 -0.09 -0.68 0.46 1475.37 1.00 217 130 37 21 FALSE 0.12
melanoma NRAS_12-61 NTRK3 Any mutation 6 42 TMB quintile 6 -0.85 -2.57 0.68 1340.31 1.00 36 4 40 2 FALSE 0.53
melanoma NRAS_12-61 NTRK3 Any mutation 157 100 TMB overall -0.45 -2.88 2.04 1104.89 1.00 253 134 77 23 FALSE 0.15
melanoma NRAS_12-61 GRIN2A Any mutation 158 166 TMB quintile 5 -0.47 -0.88 -0.06 1559.47 1.00 164 109 117 49 FALSE 1.56
melanoma NRAS_12-61 GRIN2A Any mutation 11 124 TMB quintile 6 0.12 -1.37 2.23 1358.48 1.00 17 1 114 10 FALSE 0.05
melanoma NRAS_12-61 GRIN2A Any mutation 169 290 TMB overall -0.13 -2.72 3.13 1441.03 1.00 181 110 231 59 FALSE 0.03
melanoma NRAS_12-61 ERBB4 Any mutation 150 92 TMB quintile 5 -0.43 -0.94 0.07 1537.66 1.00 195 123 65 27 TRUE 1.02
melanoma NRAS_12-61 ERBB4 Any mutation 11 89 TMB quintile 6 0.60 -0.91 2.88 1554.90 1.00 19 1 79 10 TRUE 0.28
melanoma NRAS_12-61 ERBB4 Any mutation 161 181 TMB overall 0.09 -2.85 3.42 1450.83 1.00 214 124 144 37 TRUE 0.02
melanoma NRAS_12-61 NF1 Any mutation 14 13 TMB quintile 3 -0.16 -2.05 1.41 1615.76 1.00 86 12 11 2 TRUE 0.07
melanoma NRAS_12-61 NF1 Any mutation 19 11 TMB quintile 4 -2.29 -5.90 -0.07 1343.27 1.00 77 19 11 0 TRUE 0.97
melanoma NRAS_12-61 NF1 Any mutation 149 162 TMB quintile 5 -1.37 -1.85 -0.88 1353.95 1.00 162 123 136 26 TRUE 7.42
melanoma NRAS_12-61 NF1 Any mutation 12 100 TMB quintile 6 0.83 -0.94 3.48 1533.90 1.00 12 0 88 12 TRUE 0.34
melanoma NRAS_12-61 NF1 Any mutation 194 286 TMB overall -0.70 -2.64 1.37 1660.31 1.00 337 154 246 40 TRUE 0.31
melanoma NRAS_12-61 FLT1 Any mutation 148 60 TMB quintile 5 -0.20 -0.80 0.40 1406.64 1.00 213 128 40 20 FALSE 0.30
melanoma NRAS_12-61 FLT1 Any mutation 8 56 TMB quintile 6 1.11 -0.48 3.11 1390.56 1.00 34 1 49 7 FALSE 0.62
melanoma NRAS_12-61 FLT1 Any mutation 156 116 TMB overall 0.31 -2.57 3.34 1495.93 1.00 247 129 89 27 FALSE 0.08
melanoma NRAS_12-61 ROS1 Any mutation 152 139 TMB quintile 5 -0.36 -0.80 0.08 1331.14 1.00 177 110 97 42 TRUE 0.94
melanoma NRAS_12-61 ROS1 Any mutation 12 103 TMB quintile 6 1.98 -0.33 6.15 1378.70 1.00 23 0 91 12 TRUE 0.62
melanoma NRAS_12-61 ROS1 Any mutation 164 242 TMB overall 0.68 -2.85 4.35 1646.44 1.00 200 110 188 54 TRUE 0.15
melanoma NRAS_12-61 PIK3CG Any mutation 146 43 TMB quintile 5 -0.33 -1.00 0.33 1551.26 1.00 223 133 30 13 FALSE 0.48
melanoma NRAS_12-61 PIK3CG Any mutation 8 56 TMB quintile 6 0.49 -0.90 2.21 1514.24 1.00 35 2 50 6 FALSE 0.28
melanoma NRAS_12-61 PIK3CG Any mutation 154 99 TMB overall 0.06 -2.64 2.95 1595.77 1.00 258 135 80 19 FALSE 0.02
melanoma NRAS_12-61 BRAF Any mutation 15 16 TMB quintile 2 -2.77 -5.20 -0.86 1153.96 1.00 91 15 16 0 TRUE 1.91
melanoma NRAS_12-61 BRAF Any mutation 14 27 TMB quintile 3 -2.95 -5.11 -1.28 1546.71 1.00 69 14 27 0 TRUE 2.51
melanoma NRAS_12-61 BRAF Any mutation 19 53 TMB quintile 4 -2.50 -3.95 -1.32 1455.67 1.00 36 17 51 2 TRUE 3.77
melanoma NRAS_12-61 BRAF Any mutation 149 170 TMB quintile 5 -2.35 -2.95 -1.81 1409.30 1.00 113 132 153 17 TRUE 15.60
melanoma NRAS_12-61 BRAF Any mutation 6 17 TMB quintile 6 -1.99 -3.89 -0.20 1126.69 1.00 48 5 16 1 TRUE 1.46
melanoma NRAS_12-61 BRAF Any mutation 203 283 TMB overall -2.50 -3.87 -1.32 1524.61 1.00 357 183 263 20 TRUE 3.90
melanoma NRAS_12-61 CARD11 Any mutation 148 63 TMB quintile 5 -0.54 -1.19 0.00 1450.18 1.00 212 131 46 17 FALSE 1.12
melanoma NRAS_12-61 CARD11 Any mutation 6 45 TMB quintile 6 -1.08 -2.83 0.50 1488.90 1.00 32 4 43 2 FALSE 0.72
melanoma NRAS_12-61 CARD11 Any mutation 154 108 TMB overall -0.80 -3.23 1.61 1553.48 1.00 244 135 89 19 FALSE 0.31
melanoma NRAS_12-61 TP63 Any mutation 145 95 TMB quintile 5 0.00 -0.50 0.48 1494.67 1.00 186 109 59 36 FALSE 0.00
melanoma NRAS_12-61 TP63 Any mutation 6 69 TMB quintile 6 -1.35 -3.01 0.23 1494.51 1.00 14 3 66 3 FALSE 1.03
melanoma NRAS_12-61 TP63 Any mutation 151 164 TMB overall -0.62 -3.14 2.09 1476.81 1.00 200 112 125 39 FALSE 0.19
melanoma NRAS_12-61 ZFHX3 Any mutation 142 62 TMB quintile 5 -0.48 -1.08 0.10 1475.16 1.00 204 125 45 17 FALSE 0.98
melanoma NRAS_12-61 ZFHX3 Any mutation 6 78 TMB quintile 6 -0.28 -1.96 1.46 1421.73 1.00 34 2 74 4 FALSE 0.13
melanoma NRAS_12-61 ZFHX3 Any mutation 148 140 TMB overall -0.32 -3.11 2.41 1524.23 1.00 238 127 119 21 FALSE 0.09
melanoma NRAS_12-61 PREX2 Any mutation 91 89 TMB quintile 5 0.06 -0.47 0.62 1468.03 1.00 99 57 55 34 FALSE 0.08
melanoma NRAS_12-61 PREX2 Any mutation 8 76 TMB quintile 6 0.03 -1.58 1.97 1505.82 1.00 12 1 69 7 FALSE 0.01
melanoma NRAS_12-61 PREX2 Any mutation 99 165 TMB overall 0.06 -2.51 2.94 1551.18 1.00 111 58 124 41 FALSE 0.01
melanoma NRAS_12-61 EPHA7 Any mutation 144 89 TMB quintile 5 -0.11 -0.60 0.35 1445.16 1.00 193 113 58 31 FALSE 0.19
melanoma NRAS_12-61 EPHA7 Any mutation 6 63 TMB quintile 6 -0.82 -2.34 0.64 1457.34 1.00 27 3 60 3 FALSE 0.56
melanoma NRAS_12-61 EPHA7 Any mutation 150 152 TMB overall -0.47 -2.91 2.02 1481.47 1.00 220 116 118 34 FALSE 0.15
colorectal cancer RAS_12 SPEN Any mutation 282 11 TMB quintile 4 -0.19 -1.41 0.98 1330.93 1.00 502 278 7 4 FALSE 0.12
colorectal cancer RAS_12 SPEN Any mutation 235 31 TMB quintile 5 0.01 -0.73 0.69 1464.28 1.00 376 223 19 12 FALSE 0.01
colorectal cancer RAS_12 SPEN Any mutation 20 107 TMB quintile 6 -0.44 -1.29 0.42 1425.33 1.00 62 10 97 10 FALSE 0.48
non-small cell lung cancer RAS_12 SPEN Any mutation 231 15 TMB quintile 4 -1.12 -2.40 -0.03 1376.11 1.00 518 229 13 2 FALSE 1.14
non-small cell lung cancer RAS_12 SPEN Any mutation 397 87 TMB quintile 5 -0.88 -1.47 -0.33 1194.19 1.00 784 382 72 15 FALSE 2.64
uterine cancer RAS_12 SPEN Any mutation 53 37 TMB quintile 5 0.62 -0.22 1.36 1497.05 1.00 185 42 26 11 FALSE 0.90
colorectal cancer RAS_12 SPEN Any mutation 537 149 TMB overall -0.21 -2.23 1.77 1344.70 1.00 940 511 123 26 FALSE 0.08
non-small cell lung cancer RAS_12 SPEN Any mutation 628 102 TMB overall -0.98 -2.56 0.59 1376.40 1.00 1302 611 85 17 FALSE 0.70
uterine cancer RAS_12 SPEN Any mutation 58 114 TMB overall 1.13 -2.10 4.99 1416.78 1.00 214 42 98 16 FALSE 0.29
colorectal cancer RAS_12 KMT2C Any mutation 275 12 TMB quintile 4 -0.31 -1.48 0.87 1473.44 1.00 490 271 8 4 FALSE 0.22
colorectal cancer RAS_12 KMT2C Any mutation 218 61 TMB quintile 5 -0.72 -1.36 -0.11 1419.09 1.00 331 204 47 14 FALSE 1.67
colorectal cancer RAS_12 KMT2C Any mutation 26 116 TMB quintile 6 -0.05 -0.88 0.78 1526.56 1.00 62 10 100 16 FALSE 0.04
non-small cell lung cancer RAS_12 KMT2C Any mutation 130 13 TMB quintile 3 -0.84 -2.33 0.31 1449.33 1.00 480 129 12 1 FALSE 0.69
non-small cell lung cancer RAS_12 KMT2C Any mutation 231 36 TMB quintile 4 -0.12 -0.81 0.56 1646.83 1.00 505 220 25 11 FALSE 0.13
non-small cell lung cancer RAS_12 KMT2C Any mutation 397 155 TMB quintile 5 -0.32 -0.71 0.04 1505.04 1.00 719 356 114 41 FALSE 1.04
uterine cancer RAS_12 KMT2C Any mutation 51 42 TMB quintile 5 -0.60 -1.60 0.31 1459.02 1.00 162 45 36 6 FALSE 0.67
colorectal cancer RAS_12 KMT2C Any mutation 519 189 TMB overall -0.34 -2.37 1.66 1384.95 1.00 883 485 155 34 FALSE 0.13
non-small cell lung cancer RAS_12 KMT2C Any mutation 758 204 TMB overall -0.39 -1.62 0.71 1448.49 1.00 1704 705 151 53 FALSE 0.31
uterine cancer RAS_12 KMT2C Any mutation 54 133 TMB overall -0.68 -3.74 2.45 1499.19 1.00 183 46 125 8 FALSE 0.19
cancer of unknown primary RAS_12 TP53 Any mutation 23 39 TMB quintile 2 -0.12 -0.89 0.73 1543.96 1.00 64 14 30 9 TRUE 0.11
cancer of unknown primary RAS_12 TP53 Any mutation 34 74 TMB quintile 3 -0.20 -0.87 0.46 1308.47 1.00 54 17 57 17 TRUE 0.25
cancer of unknown primary RAS_12 TP53 Any mutation 36 87 TMB quintile 4 -0.69 -1.40 -0.03 1552.45 1.00 40 20 71 16 TRUE 1.33
cancer of unknown primary RAS_12 TP53 Any mutation 38 153 TMB quintile 5 -0.62 -1.30 0.01 1421.31 1.00 41 15 130 23 TRUE 1.23
colorectal cancer RAS_12 TP53 Any mutation 17 104 TMB quintile 2 -1.42 -2.28 -0.58 1213.63 1.00 25 9 96 8 TRUE 3.04
colorectal cancer RAS_12 TP53 Any mutation 148 411 TMB quintile 3 -1.27 -1.74 -0.81 1584.58 1.00 37 48 311 100 TRUE 7.46
colorectal cancer RAS_12 TP53 Any mutation 291 655 TMB quintile 4 -1.18 -1.51 -0.85 1376.75 1.00 73 102 466 189 TRUE 11.06
colorectal cancer RAS_12 TP53 Any mutation 253 423 TMB quintile 5 -0.60 -0.92 -0.28 1590.76 1.00 134 115 285 138 TRUE 3.61
colorectal cancer RAS_12 TP53 Any mutation 24 78 TMB quintile 6 -0.72 -1.51 0.08 1527.21 1.00 77 15 69 9 TRUE 1.10
non-small cell lung cancer RAS_12 TP53 Any mutation 75 180 TMB quintile 2 -1.21 -1.79 -0.68 1518.52 1.00 204 59 164 16 TRUE 4.56
non-small cell lung cancer RAS_12 TP53 Any mutation 130 324 TMB quintile 3 -1.40 -1.82 -1.01 1431.86 1.00 218 97 291 33 TRUE 10.80
non-small cell lung cancer RAS_12 TP53 Any mutation 232 450 TMB quintile 4 -1.54 -1.87 -1.22 1391.22 1.00 178 160 378 72 TRUE 20.34
non-small cell lung cancer RAS_12 TP53 Any mutation 411 996 TMB quintile 5 -1.72 -1.99 -1.45 1478.98 1.00 130 202 787 209 TRUE 36.59
pancreatic cancer RAS_12 TP53 Any mutation 252 216 TMB quintile 2 1.75 1.35 2.23 1466.03 1.00 68 62 26 190 TRUE 14.61
pancreatic cancer RAS_12 TP53 Any mutation 421 392 TMB quintile 3 1.78 1.42 2.13 1212.17 1.00 59 75 46 346 TRUE 36.59
pancreatic cancer RAS_12 TP53 Any mutation 217 206 TMB quintile 4 1.48 1.01 1.90 1494.66 1.00 30 48 37 169 TRUE 9.66
pancreatic cancer RAS_12 TP53 Any mutation 34 34 TMB quintile 5 1.48 0.85 2.01 1434.09 1.00 13 9 9 25 TRUE 6.12
uterine cancer RAS_12 TP53 Any mutation 13 77 TMB quintile 2 -1.48 -2.64 -0.48 1555.57 1.00 59 10 74 3 TRUE 2.36
uterine cancer RAS_12 TP53 Any mutation 25 167 TMB quintile 3 -1.25 -1.99 -0.51 1440.06 1.00 69 15 157 10 TRUE 3.06
uterine cancer RAS_12 TP53 Any mutation 40 132 TMB quintile 4 -1.67 -2.39 -0.94 1566.86 1.00 80 32 124 8 TRUE 5.15
uterine cancer RAS_12 TP53 Any mutation 53 68 TMB quintile 5 -0.90 -1.67 -0.18 1420.21 1.00 159 44 59 9 TRUE 1.68
cancer of unknown primary RAS_12 TP53 Any mutation 135 378 TMB overall -0.51 -1.28 0.29 1381.91 1.00 200 68 311 67 TRUE 0.69
colorectal cancer RAS_12 TP53 Any mutation 733 1671 TMB overall -1.05 -1.79 -0.26 1238.34 1.00 346 289 1227 444 TRUE 2.17
non-small cell lung cancer RAS_12 TP53 Any mutation 848 1950 TMB overall -1.47 -2.25 -0.69 1539.73 1.00 730 518 1620 330 TRUE 3.82
pancreatic cancer RAS_12 TP53 Any mutation 924 848 TMB overall 1.62 1.18 2.07 1479.49 1.00 170 194 118 730 TRUE 12.22
uterine cancer RAS_12 TP53 Any mutation 133 483 TMB overall -1.40 -2.18 -0.66 1441.65 1.00 403 103 453 30 TRUE 3.33
colorectal cancer RAS_12 ATRX Any mutation 282 19 TMB quintile 4 -0.10 -1.05 0.73 1271.31 1.00 497 275 12 7 TRUE 0.08
colorectal cancer RAS_12 ATRX Any mutation 233 35 TMB quintile 5 -0.18 -0.91 0.50 1564.09 1.00 372 221 23 12 TRUE 0.22
colorectal cancer RAS_12 ATRX Any mutation 20 59 TMB quintile 6 -0.92 -2.06 0.08 1486.05 1.00 85 16 55 4 TRUE 1.08
non-small cell lung cancer RAS_12 ATRX Any mutation 231 32 TMB quintile 4 -0.12 -0.85 0.50 1593.47 1.00 509 222 23 9 TRUE 0.14
non-small cell lung cancer RAS_12 ATRX Any mutation 403 160 TMB quintile 5 0.24 -0.10 0.58 1466.34 1.00 745 344 101 59 TRUE 0.76
uterine cancer RAS_12 ATRX Any mutation 13 11 TMB quintile 2 -2.48 -6.36 0.27 1135.56 1.00 121 13 11 0 TRUE 0.85
uterine cancer RAS_12 ATRX Any mutation 24 14 TMB quintile 3 -2.62 -6.30 -0.06 1557.62 1.00 203 24 14 0 TRUE 0.97
uterine cancer RAS_12 ATRX Any mutation 52 19 TMB quintile 5 -0.68 -2.29 0.57 1448.43 1.00 196 49 16 3 TRUE 0.46
colorectal cancer RAS_12 ATRX Any mutation 535 113 TMB overall -0.45 -2.09 1.26 1519.21 1.00 954 512 90 23 TRUE 0.22
non-small cell lung cancer RAS_12 ATRX Any mutation 634 192 TMB overall 0.05 -1.43 1.35 1511.64 1.00 1254 566 124 68 TRUE 0.03
uterine cancer RAS_12 ATRX Any mutation 91 156 TMB overall -1.83 -4.23 0.30 1328.31 1.00 547 87 152 4 TRUE 0.95
colorectal cancer RAS_12 ATR Any mutation 233 35 TMB quintile 5 -1.14 -2.10 -0.33 1496.19 1.00 365 227 29 6 FALSE 1.99
colorectal cancer RAS_12 ATR Any mutation 23 65 TMB quintile 6 -0.48 -1.42 0.45 1459.35 1.00 90 16 58 7 FALSE 0.49
non-small cell lung cancer RAS_12 ATR Any mutation 130 12 TMB quintile 3 -0.47 -1.78 0.57 1565.41 1.00 486 128 10 2 FALSE 0.38
non-small cell lung cancer RAS_12 ATR Any mutation 231 15 TMB quintile 4 -0.57 -1.60 0.35 1500.80 1.00 521 228 12 3 FALSE 0.60
non-small cell lung cancer RAS_12 ATR Any mutation 397 93 TMB quintile 5 -0.22 -0.68 0.23 1466.13 1.00 761 371 67 26 FALSE 0.46
colorectal cancer RAS_12 ATR Any mutation 256 100 TMB overall -0.78 -2.92 1.48 1515.35 1.00 455 243 87 13 FALSE 0.32
non-small cell lung cancer RAS_12 ATR Any mutation 758 120 TMB overall -0.41 -1.49 0.51 1735.55 1.00 1768 727 89 31 FALSE 0.38
non-small cell lung cancer RAS_12 PDGFRA Any mutation 231 16 TMB quintile 4 -0.15 -1.15 0.84 1533.24 1.00 520 226 11 5 TRUE 0.12
non-small cell lung cancer RAS_12 PDGFRA Any mutation 398 115 TMB quintile 5 -0.23 -0.64 0.16 1455.75 1.00 749 366 83 32 TRUE 0.57
non-small cell lung cancer RAS_12 PDGFRA Any mutation 629 131 TMB overall -0.20 -1.95 1.57 1258.45 1.00 1269 592 94 37 TRUE 0.09
colorectal cancer RAS_12 FBXW7 Any mutation 147 22 TMB quintile 3 -0.64 -1.67 0.22 1496.75 1.00 323 143 18 4 TRUE 0.77
colorectal cancer RAS_12 FBXW7 Any mutation 285 85 TMB quintile 4 -0.10 -0.57 0.36 1436.16 1.00 461 256 56 29 TRUE 0.17
colorectal cancer RAS_12 FBXW7 Any mutation 249 160 TMB quintile 5 0.31 -0.03 0.66 1429.45 1.00 312 178 89 71 TRUE 1.12
colorectal cancer RAS_12 FBXW7 Any mutation 20 65 TMB quintile 6 -0.43 -1.37 0.44 1392.66 1.00 71 13 58 7 TRUE 0.45
uterine cancer RAS_12 FBXW7 Any mutation 24 30 TMB quintile 3 -0.84 -2.55 0.44 1398.05 1.00 189 23 29 1 TRUE 0.56
uterine cancer RAS_12 FBXW7 Any mutation 40 29 TMB quintile 4 -0.08 -1.05 0.86 1707.89 1.00 165 35 24 5 TRUE 0.06
uterine cancer RAS_12 FBXW7 Any mutation 52 30 TMB quintile 5 0.66 -0.14 1.41 1615.39 1.00 190 42 20 10 TRUE 1.00
colorectal cancer RAS_12 FBXW7 Any mutation 701 332 TMB overall -0.24 -1.25 0.77 1442.03 1.00 1167 590 221 111 TRUE 0.19
uterine cancer RAS_12 FBXW7 Any mutation 120 136 TMB overall 0.13 -1.27 1.51 1344.13 1.00 573 100 116 20 TRUE 0.07
uterine cancer RAS_12 NSD1 Any mutation 55 46 TMB quintile 5 0.10 -0.67 0.87 1408.26 1.00 182 45 36 10 FALSE 0.10
uterine cancer RAS_12 NSD1 Any mutation 59 115 TMB overall 0.68 -2.46 4.37 1632.64 1.00 206 45 101 14 FALSE 0.16
colorectal cancer RAS_12 FLT4 Any mutation 282 20 TMB quintile 4 -0.15 -1.03 0.70 1492.50 1.00 496 275 13 7 TRUE 0.13
colorectal cancer RAS_12 FLT4 Any mutation 234 40 TMB quintile 5 -0.49 -1.25 0.20 1497.15 1.00 367 223 29 11 TRUE 0.75
colorectal cancer RAS_12 FLT4 Any mutation 23 72 TMB quintile 6 0.18 -0.74 1.04 1421.03 1.00 72 11 60 12 TRUE 0.16
non-small cell lung cancer RAS_12 FLT4 Any mutation 231 14 TMB quintile 4 0.53 -0.48 1.61 1510.38 1.00 524 224 7 7 TRUE 0.50
non-small cell lung cancer RAS_12 FLT4 Any mutation 398 74 TMB quintile 5 -0.23 -0.77 0.27 1431.24 1.00 775 378 54 20 TRUE 0.41
colorectal cancer RAS_12 FLT4 Any mutation 539 132 TMB overall -0.16 -1.91 1.45 1345.91 1.00 935 509 102 30 TRUE 0.07
non-small cell lung cancer RAS_12 FLT4 Any mutation 629 88 TMB overall 0.14 -1.40 2.11 1624.96 1.00 1299 602 61 27 TRUE 0.06
colorectal cancer RAS_12 PTPRD Any mutation 233 29 TMB quintile 5 -0.71 -1.58 0.09 1350.90 1.00 373 226 22 7 FALSE 1.01
colorectal cancer RAS_12 PTPRD Any mutation 20 61 TMB quintile 6 -0.49 -1.55 0.46 1466.55 1.00 85 14 55 6 FALSE 0.48
non-small cell lung cancer RAS_12 PTPRD Any mutation 130 16 TMB quintile 3 -0.31 -1.65 0.90 1489.09 1.00 484 127 13 3 FALSE 0.20
non-small cell lung cancer RAS_12 PTPRD Any mutation 232 53 TMB quintile 4 0.39 -0.20 0.97 1569.60 1.00 499 211 32 21 FALSE 0.73
non-small cell lung cancer RAS_12 PTPRD Any mutation 409 298 TMB quintile 5 -0.16 -0.46 0.12 1620.47 1.00 655 321 210 88 FALSE 0.55
colorectal cancer RAS_12 PTPRD Any mutation 253 90 TMB overall -0.60 -2.80 1.75 1344.67 1.00 458 240 77 13 FALSE 0.21
non-small cell lung cancer RAS_12 PTPRD Any mutation 771 384 TMB overall -0.32 -2.28 1.64 1332.38 1.00 1645 659 272 112 FALSE 0.13
non-small cell lung cancer RAS_12 PIK3C2G Any mutation 231 12 TMB quintile 4 -0.49 -1.78 0.66 1270.23 1.00 519 228 9 3 FALSE 0.37
non-small cell lung cancer RAS_12 PIK3C2G Any mutation 396 103 TMB quintile 5 -0.49 -0.96 -0.02 1437.20 1.00 750 372 79 24 FALSE 1.37
non-small cell lung cancer RAS_12 PIK3C2G Any mutation 627 115 TMB overall -0.49 -2.41 1.38 1379.55 1.00 1269 600 88 27 FALSE 0.22
colorectal cancer RAS_12 CREBBP Any mutation 282 17 TMB quintile 4 -1.02 -2.30 0.04 1515.42 1.00 495 279 14 3 TRUE 1.03
colorectal cancer RAS_12 CREBBP Any mutation 236 49 TMB quintile 5 -0.26 -0.85 0.33 1458.09 1.00 364 220 33 16 TRUE 0.39
colorectal cancer RAS_12 CREBBP Any mutation 28 116 TMB quintile 6 -0.04 -0.81 0.79 1402.39 1.00 54 10 98 18 TRUE 0.03
non-small cell lung cancer RAS_12 CREBBP Any mutation 130 11 TMB quintile 3 0.03 -1.21 1.10 1528.10 1.00 488 127 8 3 TRUE 0.02
non-small cell lung cancer RAS_12 CREBBP Any mutation 231 12 TMB quintile 4 -0.07 -1.15 0.95 1347.92 1.00 523 227 8 4 TRUE 0.05
non-small cell lung cancer RAS_12 CREBBP Any mutation 396 106 TMB quintile 5 -0.31 -0.76 0.12 1547.36 1.00 757 369 79 27 TRUE 0.73
colorectal cancer RAS_12 CREBBP Any mutation 546 182 TMB overall -0.44 -2.40 1.37 1375.61 1.00 913 509 145 37 TRUE 0.18
non-small cell lung cancer RAS_12 CREBBP Any mutation 757 129 TMB overall -0.11 -1.23 1.17 1583.09 1.00 1768 723 95 34 TRUE 0.06
colorectal cancer RAS_12 AXIN2 Any mutation 282 20 TMB quintile 4 0.39 -0.49 1.26 1474.30 1.00 499 272 10 10 TRUE 0.42
colorectal cancer RAS_12 AXIN2 Any mutation 233 27 TMB quintile 5 -0.78 -1.74 0.09 1299.78 1.00 373 227 21 6 TRUE 1.00
colorectal cancer RAS_12 AXIN2 Any mutation 20 63 TMB quintile 6 -1.06 -2.21 -0.09 1143.37 1.00 79 16 59 4 TRUE 1.25
colorectal cancer RAS_12 AXIN2 Any mutation 535 110 TMB overall -0.49 -2.27 1.21 1417.64 1.00 951 515 90 20 TRUE 0.23
non-small cell lung cancer RAS_12 DOT1L Any mutation 231 24 TMB quintile 4 -0.30 -1.12 0.42 1329.60 1.00 515 225 18 6 FALSE 0.36
non-small cell lung cancer RAS_12 DOT1L Any mutation 397 75 TMB quintile 5 -0.17 -0.64 0.33 1387.05 1.00 774 375 53 22 FALSE 0.30
non-small cell lung cancer RAS_12 DOT1L Any mutation 628 99 TMB overall -0.22 -1.10 0.72 1387.91 1.00 1289 600 71 28 FALSE 0.18
colorectal cancer RAS_12 PTPRS Any mutation 143 17 TMB quintile 3 -0.46 -1.54 0.57 1428.65 1.00 326 139 13 4 FALSE 0.39
colorectal cancer RAS_12 PTPRS Any mutation 275 34 TMB quintile 4 0.04 -0.69 0.75 1435.56 1.00 477 262 21 13 FALSE 0.04
colorectal cancer RAS_12 PTPRS Any mutation 221 74 TMB quintile 5 -0.24 -0.76 0.25 1516.30 1.00 329 197 50 24 FALSE 0.45
colorectal cancer RAS_12 PTPRS Any mutation 25 128 TMB quintile 6 -0.41 -1.29 0.44 1265.99 1.00 40 9 112 16 FALSE 0.46
colorectal cancer RAS_12 PTPRS Any mutation 664 253 TMB overall -0.29 -1.75 1.18 1285.54 1.00 1172 607 196 57 FALSE 0.16
colorectal cancer RAS_12 SMARCA4 Any mutation 282 16 TMB quintile 4 -0.61 -1.78 0.44 1683.54 1.00 497 278 12 4 FALSE 0.55
colorectal cancer RAS_12 SMARCA4 Any mutation 234 47 TMB quintile 5 -0.28 -0.91 0.37 1295.70 1.00 364 219 32 15 FALSE 0.41
colorectal cancer RAS_12 SMARCA4 Any mutation 24 100 TMB quintile 6 0.02 -0.81 0.92 1483.95 1.00 65 10 86 14 FALSE 0.02
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 131 35 TMB quintile 3 0.82 0.14 1.51 1436.40 1.00 479 116 20 15 FALSE 1.71
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 232 67 TMB quintile 4 0.15 -0.40 0.63 1488.12 1.00 489 210 45 22 FALSE 0.24
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 400 194 TMB quintile 5 -0.09 -0.45 0.23 1401.36 1.00 698 342 136 58 FALSE 0.22
uterine cancer RAS_12 SMARCA4 Any mutation 54 39 TMB quintile 5 -0.23 -1.14 0.60 1443.73 1.00 186 47 32 7 FALSE 0.22
colorectal cancer RAS_12 SMARCA4 Any mutation 540 163 TMB overall -0.29 -2.18 1.74 1451.98 1.00 926 507 130 33 FALSE 0.12
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 763 296 TMB overall 0.27 -0.63 1.17 1433.58 1.00 1666 668 201 95 FALSE 0.26
uterine cancer RAS_12 SMARCA4 Any mutation 56 91 TMB overall -0.44 -3.24 2.45 1543.55 1.00 216 48 83 8 FALSE 0.12
colorectal cancer RAS_12 PTPRT Any mutation 147 18 TMB quintile 3 0.36 -0.54 1.19 1373.22 1.00 330 139 10 8 FALSE 0.37
colorectal cancer RAS_12 PTPRT Any mutation 282 39 TMB quintile 4 -1.26 -2.17 -0.48 1559.68 1.00 475 277 34 5 FALSE 2.41
colorectal cancer RAS_12 PTPRT Any mutation 235 59 TMB quintile 5 -0.59 -1.21 -0.03 1686.03 1.00 350 220 44 15 FALSE 1.28
colorectal cancer RAS_12 PTPRT Any mutation 22 66 TMB quintile 6 0.21 -0.62 1.00 1430.87 1.00 82 11 55 11 FALSE 0.21
non-small cell lung cancer RAS_12 PTPRT Any mutation 130 17 TMB quintile 3 -0.02 -1.19 0.98 1383.80 1.00 483 126 13 4 FALSE 0.01
non-small cell lung cancer RAS_12 PTPRT Any mutation 231 38 TMB quintile 4 -0.13 -0.85 0.60 1596.06 1.00 505 220 27 11 FALSE 0.14
non-small cell lung cancer RAS_12 PTPRT Any mutation 405 272 TMB quintile 5 -0.40 -0.72 -0.08 1518.09 1.00 667 336 203 69 FALSE 1.85
colorectal cancer RAS_12 PTPRT Any mutation 686 182 TMB overall -0.34 -1.56 0.86 1454.35 1.00 1237 647 143 39 FALSE 0.24
non-small cell lung cancer RAS_12 PTPRT Any mutation 766 348 TMB overall -0.51 -2.80 1.47 1642.53 1.00 1660 682 264 84 FALSE 0.20
non-small cell lung cancer RAS_12 HGF Any mutation 231 27 TMB quintile 4 -0.31 -1.26 0.52 1350.17 1.00 512 224 20 7 FALSE 0.31
non-small cell lung cancer RAS_12 HGF Any mutation 398 138 TMB quintile 5 -0.24 -0.64 0.15 1534.26 1.00 733 359 99 39 FALSE 0.61
non-small cell lung cancer RAS_12 HGF Any mutation 629 180 TMB overall -0.71 -3.43 1.84 1457.46 1.00 1252 583 134 46 FALSE 0.23
colorectal cancer RAS_12 PIK3CA Any mutation 149 51 TMB quintile 3 0.75 0.17 1.32 1501.96 1.00 315 124 26 25 TRUE 1.99
colorectal cancer RAS_12 PIK3CA Any mutation 285 146 TMB quintile 4 0.53 0.19 0.88 1218.96 1.00 434 217 78 68 TRUE 2.48
colorectal cancer RAS_12 PIK3CA Any mutation 240 209 TMB quintile 5 0.07 -0.27 0.40 1463.41 1.00 278 161 130 79 TRUE 0.17
colorectal cancer RAS_12 PIK3CA Any mutation 23 95 TMB quintile 6 -0.31 -1.09 0.45 1691.74 1.00 60 12 84 11 TRUE 0.35
non-small cell lung cancer RAS_12 PIK3CA Any mutation 75 18 TMB quintile 2 -0.69 -1.62 0.14 1575.56 1.00 349 74 17 1 TRUE 0.89
non-small cell lung cancer RAS_12 PIK3CA Any mutation 130 34 TMB quintile 3 -0.49 -1.23 0.15 1236.16 1.00 467 125 29 5 TRUE 0.77
non-small cell lung cancer RAS_12 PIK3CA Any mutation 232 56 TMB quintile 4 -0.55 -1.13 0.00 1620.40 1.00 486 221 45 11 TRUE 1.26
non-small cell lung cancer RAS_12 PIK3CA Any mutation 397 123 TMB quintile 5 -0.16 -0.57 0.22 1523.15 1.00 749 360 86 37 TRUE 0.37
uterine cancer RAS_12 PIK3CA Any mutation 13 33 TMB quintile 2 -0.29 -1.47 0.80 1319.51 1.00 102 11 31 2 TRUE 0.21
uterine cancer RAS_12 PIK3CA Any mutation 24 103 TMB quintile 3 0.05 -0.76 0.84 1518.12 1.00 134 14 93 10 TRUE 0.04
uterine cancer RAS_12 PIK3CA Any mutation 45 121 TMB quintile 4 0.70 0.08 1.33 1500.56 1.00 109 16 92 29 TRUE 1.53
uterine cancer RAS_12 PIK3CA Any mutation 66 196 TMB quintile 5 0.48 -0.10 1.02 1488.46 1.00 101 20 150 46 TRUE 1.05
colorectal cancer RAS_12 PIK3CA Any mutation 697 501 TMB overall 0.26 -0.71 1.21 1436.49 1.00 1087 514 318 183 TRUE 0.23
non-small cell lung cancer RAS_12 PIK3CA Any mutation 834 231 TMB overall -0.47 -1.11 0.10 1408.89 1.00 2051 780 177 54 TRUE 0.90
uterine cancer RAS_12 PIK3CA Any mutation 152 548 TMB overall 0.17 -0.73 1.06 1380.41 1.00 461 61 457 91 TRUE 0.15
colorectal cancer RAS_12 ALK Any mutation 282 20 TMB quintile 4 -0.69 -1.69 0.23 1408.50 1.00 494 277 15 5 TRUE 0.77
colorectal cancer RAS_12 ALK Any mutation 233 42 TMB quintile 5 -0.87 -1.64 -0.20 1259.35 1.00 362 224 33 9 TRUE 1.69
colorectal cancer RAS_12 ALK Any mutation 20 45 TMB quintile 6 -0.98 -2.21 0.07 1315.47 1.00 93 17 42 3 TRUE 1.03
non-small cell lung cancer RAS_12 ALK Any mutation 130 13 TMB quintile 3 -0.55 -2.12 0.81 1272.61 1.00 486 128 11 2 TRUE 0.33
non-small cell lung cancer RAS_12 ALK Any mutation 231 22 TMB quintile 4 0.17 -0.70 1.03 1526.47 1.00 518 223 14 8 TRUE 0.16
non-small cell lung cancer RAS_12 ALK Any mutation 396 118 TMB quintile 5 -0.06 -0.48 0.34 1450.07 1.00 752 359 81 37 TRUE 0.10
colorectal cancer RAS_12 ALK Any mutation 535 107 TMB overall -0.82 -2.27 0.60 1426.13 1.00 949 518 90 17 TRUE 0.60
non-small cell lung cancer RAS_12 ALK Any mutation 757 164 TMB overall -0.34 -2.33 1.59 1535.41 1.00 1765 710 117 47 TRUE 0.14
colorectal cancer RAS_12 RNF43 Any mutation 147 12 TMB quintile 3 -0.98 -2.44 0.29 1273.21 1.00 330 145 10 2 TRUE 0.76
colorectal cancer RAS_12 RNF43 Any mutation 282 30 TMB quintile 4 -0.53 -1.38 0.27 1136.47 1.00 488 274 22 8 TRUE 0.70
colorectal cancer RAS_12 RNF43 Any mutation 238 76 TMB quintile 5 -0.91 -1.50 -0.38 1553.53 1.00 342 222 60 16 TRUE 2.75
colorectal cancer RAS_12 RNF43 Any mutation 25 146 TMB quintile 6 -0.58 -1.40 0.29 1583.08 1.00 40 9 130 16 TRUE 0.77
colorectal cancer RAS_12 RNF43 Any mutation 692 264 TMB overall -0.73 -2.26 0.87 1427.03 1.00 1200 650 222 42 TRUE 0.45
colorectal cancer RAS_12 PTEN Any mutation 282 29 TMB quintile 4 -0.05 -0.82 0.69 1434.13 1.00 492 271 18 11 TRUE 0.05
colorectal cancer RAS_12 PTEN Any mutation 233 69 TMB quintile 5 -0.88 -1.51 -0.32 1518.80 1.00 354 219 55 14 TRUE 2.50
colorectal cancer RAS_12 PTEN Any mutation 24 80 TMB quintile 6 -0.30 -1.12 0.50 1362.78 1.00 76 14 70 10 TRUE 0.32
non-small cell lung cancer RAS_12 PTEN Any mutation 130 17 TMB quintile 3 -1.46 -2.78 -0.36 1368.57 1.00 480 129 16 1 TRUE 1.79
non-small cell lung cancer RAS_12 PTEN Any mutation 231 27 TMB quintile 4 -1.73 -3.18 -0.75 1413.16 1.00 506 230 26 1 TRUE 2.31
non-small cell lung cancer RAS_12 PTEN Any mutation 396 75 TMB quintile 5 -1.02 -1.61 -0.42 1470.63 1.00 771 383 62 13 TRUE 2.94
uterine cancer RAS_12 PTEN Any mutation 13 16 TMB quintile 2 -0.29 -2.07 1.22 1365.96 1.00 118 12 15 1 TRUE 0.14
uterine cancer RAS_12 PTEN Any mutation 26 63 TMB quintile 3 0.48 -0.38 1.30 1402.04 1.00 178 17 54 9 TRUE 0.57
uterine cancer RAS_12 PTEN Any mutation 49 120 TMB quintile 4 0.50 -0.10 1.07 1415.63 1.00 126 22 93 27 TRUE 1.02
uterine cancer RAS_12 PTEN Any mutation 82 315 TMB quintile 5 0.51 -0.14 1.19 1602.83 1.00 58 11 244 71 TRUE 0.87
uterine cancer RAS_12 PTEN Any mutation 6 103 TMB quintile 6 0.39 -1.18 2.35 1345.39 1.00 13 0 97 6 TRUE 0.18
colorectal cancer RAS_12 PTEN Any mutation 539 178 TMB overall -0.43 -1.99 1.18 1451.88 1.00 922 504 143 35 TRUE 0.23
non-small cell lung cancer RAS_12 PTEN Any mutation 757 119 TMB overall -1.39 -2.58 -0.44 1453.38 1.00 1757 742 104 15 TRUE 2.03
uterine cancer RAS_12 PTEN Any mutation 176 617 TMB overall 0.30 -1.02 1.67 1552.00 1.00 493 62 503 114 TRUE 0.19
colorectal cancer RAS_12 BCOR Any mutation 282 11 TMB quintile 4 0.49 -0.64 1.66 1484.50 1.00 504 276 5 6 FALSE 0.41
colorectal cancer RAS_12 BCOR Any mutation 233 39 TMB quintile 5 0.04 -0.65 0.70 1401.70 1.00 372 218 24 15 FALSE 0.04
colorectal cancer RAS_12 BCOR Any mutation 23 57 TMB quintile 6 -0.77 -1.79 0.15 1517.27 1.00 81 18 52 5 FALSE 0.90
non-small cell lung cancer RAS_12 BCOR Any mutation 231 22 TMB quintile 4 0.02 -0.77 0.71 1406.88 1.00 517 224 15 7 FALSE 0.01
non-small cell lung cancer RAS_12 BCOR Any mutation 401 92 TMB quintile 5 0.27 -0.16 0.70 1346.08 1.00 773 366 57 35 FALSE 0.65
uterine cancer RAS_12 BCOR Any mutation 40 19 TMB quintile 4 0.10 -1.08 1.17 1560.75 1.00 174 36 15 4 FALSE 0.07
uterine cancer RAS_12 BCOR Any mutation 54 69 TMB quintile 5 0.33 -0.32 0.96 1437.63 1.00 162 37 52 17 FALSE 0.51
colorectal cancer RAS_12 BCOR Any mutation 538 107 TMB overall -0.08 -2.00 2.03 1534.32 1.00 957 512 81 26 FALSE 0.03
non-small cell lung cancer RAS_12 BCOR Any mutation 632 114 TMB overall 0.14 -1.01 1.26 1530.74 1.00 1290 590 72 42 FALSE 0.10
uterine cancer RAS_12 BCOR Any mutation 96 134 TMB overall 0.00 -1.80 1.67 1727.63 1.00 371 74 112 22 FALSE 0.00
colorectal cancer RAS_12 CTNNB1 Any mutation 147 38 TMB quintile 3 0.60 -0.06 1.25 1536.77 1.00 321 130 21 17 TRUE 1.14
colorectal cancer RAS_12 CTNNB1 Any mutation 283 35 TMB quintile 4 0.62 0.00 1.25 1583.99 1.00 493 264 16 19 TRUE 1.21
colorectal cancer RAS_12 CTNNB1 Any mutation 235 48 TMB quintile 5 0.12 -0.44 0.66 1513.17 1.00 364 216 29 19 TRUE 0.18
colorectal cancer RAS_12 CTNNB1 Any mutation 21 35 TMB quintile 6 -0.17 -1.24 0.72 1515.51 1.00 91 17 31 4 TRUE 0.13
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 75 12 TMB quintile 2 -0.86 -1.89 0.04 1564.86 1.00 355 74 11 1 TRUE 1.08
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 130 22 TMB quintile 3 -1.12 -2.33 -0.25 1324.29 1.00 474 130 22 0 TRUE 1.44
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 233 33 TMB quintile 4 -0.58 -1.24 0.07 1488.28 1.00 507 225 25 8 TRUE 1.03
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 396 47 TMB quintile 5 -0.70 -1.36 -0.10 1436.45 1.00 790 386 37 10 TRUE 1.55
uterine cancer RAS_12 CTNNB1 Any mutation 24 28 TMB quintile 3 -2.22 -4.26 -0.85 1314.78 1.01 189 24 28 0 TRUE 1.91
uterine cancer RAS_12 CTNNB1 Any mutation 40 33 TMB quintile 4 -1.48 -2.78 -0.29 1483.89 1.00 159 37 30 3 TRUE 1.72
uterine cancer RAS_12 CTNNB1 Any mutation 52 61 TMB quintile 5 -2.12 -3.42 -1.08 1491.72 1.00 154 50 59 2 TRUE 3.34
colorectal cancer RAS_12 CTNNB1 Any mutation 686 156 TMB overall 0.29 -0.52 1.15 1646.67 1.00 1269 627 97 59 TRUE 0.31
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 834 114 TMB overall -0.81 -1.57 -0.11 1378.73 1.00 2126 815 95 19 TRUE 1.50
uterine cancer RAS_12 CTNNB1 Any mutation 118 137 TMB overall -1.96 -3.35 -0.81 1462.75 1.00 548 113 132 5 TRUE 2.58
cancer of unknown primary RAS_12 ARID1A Any mutation 35 15 TMB quintile 4 -0.04 -1.21 0.99 1558.12 1.00 96 31 11 4 TRUE 0.02
cancer of unknown primary RAS_12 ARID1A Any mutation 37 62 TMB quintile 5 -0.32 -1.09 0.46 1355.88 1.00 113 28 53 9 TRUE 0.38
cancer of unknown primary RAS_12 ARID1A Any mutation 7 16 TMB quintile 6 0.41 -0.84 1.85 1381.37 1.00 8 2 11 5 TRUE 0.26
colorectal cancer RAS_12 ARID1A Any mutation 283 32 TMB quintile 4 0.36 -0.33 1.04 1681.44 1.00 492 268 17 15 TRUE 0.52
colorectal cancer RAS_12 ARID1A Any mutation 238 116 TMB quintile 5 -0.81 -1.30 -0.35 1357.58 1.00 326 212 90 26 TRUE 3.05
colorectal cancer RAS_12 ARID1A Any mutation 29 155 TMB quintile 6 -0.32 -1.16 0.54 1503.14 1.00 44 9 135 20 TRUE 0.34
non-small cell lung cancer RAS_12 ARID1A Any mutation 130 12 TMB quintile 3 -0.15 -1.32 0.93 1446.40 1.00 487 127 9 3 TRUE 0.10
non-small cell lung cancer RAS_12 ARID1A Any mutation 231 56 TMB quintile 4 -0.48 -1.12 0.08 1557.98 1.00 490 219 44 12 TRUE 0.91
non-small cell lung cancer RAS_12 ARID1A Any mutation 405 187 TMB quintile 5 -0.28 -0.63 0.06 1504.12 1.00 702 354 136 51 TRUE 0.96
pancreatic cancer RAS_12 ARID1A Any mutation 252 13 TMB quintile 2 -0.95 -1.85 -0.09 1545.83 1.00 87 246 7 6 TRUE 1.46
pancreatic cancer RAS_12 ARID1A Any mutation 420 44 TMB quintile 3 0.04 -0.59 0.77 1380.15 1.00 97 383 7 37 TRUE 0.05
pancreatic cancer RAS_12 ARID1A Any mutation 219 45 TMB quintile 4 -0.16 -0.81 0.45 1318.27 1.00 54 186 12 33 TRUE 0.21
pancreatic cancer RAS_12 ARID1A Any mutation 35 17 TMB quintile 5 0.00 -0.87 0.90 1268.29 1.00 16 25 7 10 TRUE 0.00
uterine cancer RAS_12 ARID1A Any mutation 24 28 TMB quintile 3 0.41 -0.77 1.46 1510.42 1.00 194 20 24 4 TRUE 0.33
uterine cancer RAS_12 ARID1A Any mutation 44 77 TMB quintile 4 1.24 0.60 1.92 1561.53 1.00 142 19 52 25 TRUE 3.61
uterine cancer RAS_12 ARID1A Any mutation 74 307 TMB quintile 5 0.70 0.01 1.47 1357.29 1.00 62 9 242 65 TRUE 1.18
cancer of unknown primary RAS_12 ARID1A Any mutation 79 93 TMB overall 0.01 -1.40 1.33 1621.44 1.00 217 61 75 18 TRUE 0.01
colorectal cancer RAS_12 ARID1A Any mutation 550 303 TMB overall -0.24 -2.13 1.68 1575.86 1.00 862 489 242 61 TRUE 0.10
non-small cell lung cancer RAS_12 ARID1A Any mutation 766 255 TMB overall -0.30 -1.45 0.88 1465.39 1.00 1679 700 189 66 TRUE 0.22
pancreatic cancer RAS_12 ARID1A Any mutation 926 119 TMB overall -0.28 -1.13 0.56 1396.39 1.00 254 840 33 86 TRUE 0.29
uterine cancer RAS_12 ARID1A Any mutation 145 520 TMB overall 0.60 -1.12 2.35 1427.25 1.00 407 48 423 97 TRUE 0.31
colorectal cancer RAS_12 PIK3R1 Any mutation 282 22 TMB quintile 4 -0.04 -0.87 0.76 1596.99 1.00 496 274 14 8 TRUE 0.03
colorectal cancer RAS_12 PIK3R1 Any mutation 234 29 TMB quintile 5 0.38 -0.37 1.13 1351.96 1.00 380 220 15 14 TRUE 0.50
colorectal cancer RAS_12 PIK3R1 Any mutation 22 56 TMB quintile 6 -0.20 -1.15 0.64 1533.39 1.00 85 15 49 7 TRUE 0.17
uterine cancer RAS_12 PIK3R1 Any mutation 24 40 TMB quintile 3 -0.86 -2.07 0.20 1482.31 1.00 183 22 38 2 TRUE 0.86
uterine cancer RAS_12 PIK3R1 Any mutation 42 68 TMB quintile 4 -0.52 -1.30 0.18 1217.74 1.00 140 33 59 9 TRUE 0.77
uterine cancer RAS_12 PIK3R1 Any mutation 58 117 TMB quintile 5 -0.43 -1.05 0.14 1548.88 1.00 135 39 98 19 TRUE 0.83
colorectal cancer RAS_12 PIK3R1 Any mutation 538 107 TMB overall 0.01 -1.57 1.48 1477.86 1.00 961 509 78 29 TRUE 0.01
uterine cancer RAS_12 PIK3R1 Any mutation 126 262 TMB overall -0.76 -1.84 0.22 1411.60 1.00 491 96 232 30 TRUE 0.81
colorectal cancer RAS_12 FAT1 Any mutation 282 17 TMB quintile 4 -0.20 -1.26 0.79 1479.70 1.00 499 276 11 6 FALSE 0.16
colorectal cancer RAS_12 FAT1 Any mutation 235 64 TMB quintile 5 -0.83 -1.47 -0.25 1504.50 1.00 350 221 50 14 FALSE 2.17
colorectal cancer RAS_12 FAT1 Any mutation 25 145 TMB quintile 6 -0.86 -1.68 -0.07 1104.18 1.00 51 12 132 13 FALSE 1.40
non-small cell lung cancer RAS_12 FAT1 Any mutation 130 16 TMB quintile 3 0.05 -1.12 1.09 1630.74 1.00 484 126 12 4 FALSE 0.03
non-small cell lung cancer RAS_12 FAT1 Any mutation 231 43 TMB quintile 4 -0.29 -1.00 0.39 1422.34 1.00 504 220 32 11 FALSE 0.38
non-small cell lung cancer RAS_12 FAT1 Any mutation 401 227 TMB quintile 5 -0.26 -0.58 0.05 1350.79 1.00 681 338 164 63 FALSE 1.00
uterine cancer RAS_12 FAT1 Any mutation 53 49 TMB quintile 5 0.06 -0.77 0.83 1479.48 1.00 182 43 39 10 FALSE 0.06
colorectal cancer RAS_12 FAT1 Any mutation 542 226 TMB overall -0.65 -2.93 1.46 1433.84 1.00 900 509 193 33 FALSE 0.27
non-small cell lung cancer RAS_12 FAT1 Any mutation 762 300 TMB overall -0.42 -2.17 1.36 1099.14 1.00 1676 684 222 78 FALSE 0.19
uterine cancer RAS_12 FAT1 Any mutation 57 164 TMB overall 0.40 -2.96 4.35 1489.82 1.00 199 43 150 14 FALSE 0.08
colorectal cancer RAS_12 CIC Any mutation 282 17 TMB quintile 4 0.09 -0.83 1.02 1467.52 1.00 500 275 10 7 TRUE 0.07
colorectal cancer RAS_12 CIC Any mutation 235 40 TMB quintile 5 -0.24 -0.87 0.39 1242.74 1.00 369 222 27 13 TRUE 0.33
colorectal cancer RAS_12 CIC Any mutation 22 79 TMB quintile 6 -0.14 -0.98 0.68 1599.25 1.00 74 12 69 10 TRUE 0.13
colorectal cancer RAS_12 CIC Any mutation 539 136 TMB overall -0.09 -1.87 1.63 1365.68 1.00 943 509 106 30 TRUE 0.04
colorectal cancer RAS_12 NCOR1 Any mutation 282 16 TMB quintile 4 -0.63 -1.77 0.37 1517.07 1.00 497 278 12 4 FALSE 0.59
colorectal cancer RAS_12 NCOR1 Any mutation 234 32 TMB quintile 5 -0.78 -1.65 -0.03 1401.38 1.00 373 227 25 7 FALSE 1.21
colorectal cancer RAS_12 NCOR1 Any mutation 23 81 TMB quintile 6 0.23 -0.63 1.08 1559.50 1.00 71 10 68 13 FALSE 0.23
non-small cell lung cancer RAS_12 NCOR1 Any mutation 231 21 TMB quintile 4 -0.58 -1.54 0.22 1307.68 1.00 515 227 17 4 FALSE 0.72
non-small cell lung cancer RAS_12 NCOR1 Any mutation 399 71 TMB quintile 5 -0.32 -0.84 0.18 1457.82 1.00 781 380 52 19 FALSE 0.63
colorectal cancer RAS_12 NCOR1 Any mutation 539 129 TMB overall -0.37 -2.21 1.56 1590.00 1.00 941 515 105 24 FALSE 0.15
non-small cell lung cancer RAS_12 NCOR1 Any mutation 630 92 TMB overall -0.44 -1.50 0.65 1378.47 1.00 1296 607 69 23 FALSE 0.39
colorectal cancer RAS_12 POLE Any mutation 233 38 TMB quintile 5 -0.56 -1.34 0.14 1683.51 1.00 367 223 28 10 TRUE 0.87
colorectal cancer RAS_12 POLE Any mutation 23 93 TMB quintile 6 0.01 -0.85 0.89 1603.34 1.00 65 10 80 13 TRUE 0.01
non-small cell lung cancer RAS_12 POLE Any mutation 231 20 TMB quintile 4 0.14 -0.70 0.97 1573.26 1.00 518 224 13 7 TRUE 0.14
non-small cell lung cancer RAS_12 POLE Any mutation 398 102 TMB quintile 5 0.33 -0.07 0.73 1458.08 1.00 770 358 62 40 TRUE 0.95
uterine cancer RAS_12 POLE Any mutation 52 24 TMB quintile 5 0.27 -0.75 1.26 1590.20 1.00 194 46 18 6 TRUE 0.22
colorectal cancer RAS_12 POLE Any mutation 256 131 TMB overall -0.27 -2.83 2.46 1614.36 1.00 432 233 108 23 TRUE 0.08
non-small cell lung cancer RAS_12 POLE Any mutation 629 122 TMB overall 0.23 -1.30 1.59 1644.97 1.00 1288 582 75 47 TRUE 0.13
uterine cancer RAS_12 POLE Any mutation 55 104 TMB overall 0.71 -2.87 4.91 1489.78 1.00 217 46 95 9 TRUE 0.15
non-small cell lung cancer RAS_12 NOTCH2 Any mutation 231 16 TMB quintile 4 0.01 -0.90 0.95 1461.68 1.00 519 225 10 6 TRUE 0.01
non-small cell lung cancer RAS_12 NOTCH2 Any mutation 395 81 TMB quintile 5 -0.49 -1.05 0.03 1529.19 1.00 767 377 63 18 TRUE 1.13
non-small cell lung cancer RAS_12 NOTCH2 Any mutation 626 97 TMB overall -0.27 -1.80 1.48 1509.19 1.00 1286 602 73 24 TRUE 0.14
colorectal cancer RAS_12 TGFBR2 Any mutation 234 47 TMB quintile 5 -0.39 -1.02 0.22 1456.69 1.00 364 220 33 14 TRUE 0.64
colorectal cancer RAS_12 TGFBR2 Any mutation 21 57 TMB quintile 6 -0.39 -1.35 0.55 1387.55 1.00 72 14 50 7 TRUE 0.38
colorectal cancer RAS_12 TGFBR2 Any mutation 255 104 TMB overall -0.30 -2.53 2.12 1576.20 1.00 436 234 83 21 TRUE 0.11
colorectal cancer RAS_12 KMT2A Any mutation 282 16 TMB quintile 4 -0.36 -1.46 0.60 1340.73 1.00 498 277 11 5 FALSE 0.32
colorectal cancer RAS_12 KMT2A Any mutation 233 43 TMB quintile 5 -0.48 -1.18 0.16 1432.84 1.00 366 221 31 12 FALSE 0.79
colorectal cancer RAS_12 KMT2A Any mutation 21 84 TMB quintile 6 -0.52 -1.44 0.35 1332.93 1.00 75 13 76 8 FALSE 0.60
non-small cell lung cancer RAS_12 KMT2A Any mutation 231 16 TMB quintile 4 -0.24 -1.21 0.72 1412.41 1.00 520 226 11 5 FALSE 0.20
non-small cell lung cancer RAS_12 KMT2A Any mutation 396 80 TMB quintile 5 -0.49 -1.00 0.01 1464.66 1.00 770 378 62 18 FALSE 1.15
uterine cancer RAS_12 KMT2A Any mutation 52 27 TMB quintile 5 -0.53 -1.71 0.52 1526.94 1.00 188 48 23 4 FALSE 0.46
colorectal cancer RAS_12 KMT2A Any mutation 536 143 TMB overall -0.46 -2.32 1.27 1456.79 1.00 939 511 118 25 FALSE 0.22
non-small cell lung cancer RAS_12 KMT2A Any mutation 627 96 TMB overall -0.38 -1.83 1.00 1665.65 1.00 1290 604 73 23 FALSE 0.22
uterine cancer RAS_12 KMT2A Any mutation 55 103 TMB overall -0.47 -3.69 2.89 1488.74 1.00 216 49 97 6 FALSE 0.11
non-small cell lung cancer RAS_12 PAK7 Any mutation 231 13 TMB quintile 4 -0.14 -1.22 0.86 1438.98 1.00 519 227 9 4 FALSE 0.10
non-small cell lung cancer RAS_12 PAK7 Any mutation 396 95 TMB quintile 5 -0.03 -0.46 0.40 1556.39 1.00 765 366 65 30 FALSE 0.05
non-small cell lung cancer RAS_12 PAK7 Any mutation 627 108 TMB overall -0.09 -1.78 1.56 1560.56 1.00 1284 593 74 34 FALSE 0.04
non-small cell lung cancer RAS_12 STAG2 Any mutation 231 19 TMB quintile 4 -0.01 -0.88 0.72 1507.18 1.00 518 225 13 6 TRUE 0.01
non-small cell lung cancer RAS_12 STAG2 Any mutation 397 76 TMB quintile 5 0.16 -0.32 0.62 1274.45 1.00 783 370 49 27 TRUE 0.29
non-small cell lung cancer RAS_12 STAG2 Any mutation 628 95 TMB overall 0.08 -1.22 1.28 1562.07 1.00 1301 595 62 33 TRUE 0.05
non-small cell lung cancer RAS_12 TERT Any mutation 131 13 TMB quintile 3 0.61 -0.28 1.65 1636.52 1.00 489 125 7 6 TRUE 0.64
non-small cell lung cancer RAS_12 TERT Any mutation 231 34 TMB quintile 4 0.13 -0.55 0.76 1720.77 1.00 509 220 23 11 TRUE 0.16
non-small cell lung cancer RAS_12 TERT Any mutation 398 98 TMB quintile 5 0.03 -0.40 0.44 1428.33 1.00 765 367 67 31 TRUE 0.04
non-small cell lung cancer RAS_12 TERT Any mutation 760 145 TMB overall 0.27 -0.58 1.28 1673.66 1.00 1763 712 97 48 TRUE 0.24
colorectal cancer RAS_12 BRCA2 Any mutation 282 21 TMB quintile 4 -0.48 -1.45 0.42 1374.22 1.00 494 276 15 6 TRUE 0.51
colorectal cancer RAS_12 BRCA2 Any mutation 235 48 TMB quintile 5 -0.42 -1.05 0.21 1399.18 1.00 365 221 34 14 TRUE 0.72
colorectal cancer RAS_12 BRCA2 Any mutation 21 116 TMB quintile 6 -0.94 -1.86 -0.10 1679.27 1.00 68 13 108 8 TRUE 1.43
non-small cell lung cancer RAS_12 BRCA2 Any mutation 231 23 TMB quintile 4 -0.12 -1.04 0.68 1354.93 1.00 516 224 16 7 TRUE 0.10
non-small cell lung cancer RAS_12 BRCA2 Any mutation 398 89 TMB quintile 5 -0.24 -0.72 0.21 1472.32 1.00 766 373 64 25 TRUE 0.50
uterine cancer RAS_12 BRCA2 Any mutation 52 29 TMB quintile 5 -0.60 -1.79 0.40 1430.79 1.00 185 48 25 4 TRUE 0.55
colorectal cancer RAS_12 BRCA2 Any mutation 538 185 TMB overall -0.59 -2.48 1.21 1456.91 1.00 927 510 157 28 TRUE 0.27
non-small cell lung cancer RAS_12 BRCA2 Any mutation 629 126 TMB overall -0.60 -3.47 1.93 1727.78 1.00 1291 597 94 32 TRUE 0.18
uterine cancer RAS_12 BRCA2 Any mutation 55 122 TMB overall -0.66 -3.85 2.57 1661.75 1.00 210 49 116 6 TRUE 0.17
colorectal cancer RAS_12 NOTCH3 Any mutation 147 12 TMB quintile 3 0.57 -0.57 1.67 1492.79 1.00 334 141 6 6 TRUE 0.51
colorectal cancer RAS_12 NOTCH3 Any mutation 282 17 TMB quintile 4 0.10 -0.90 1.03 1469.14 1.00 499 275 10 7 TRUE 0.08
colorectal cancer RAS_12 NOTCH3 Any mutation 233 50 TMB quintile 5 -0.92 -1.63 -0.24 1312.92 1.00 358 223 40 10 TRUE 1.99
colorectal cancer RAS_12 NOTCH3 Any mutation 22 120 TMB quintile 6 -0.96 -1.85 -0.10 1250.33 1.00 47 12 110 10 TRUE 1.52
non-small cell lung cancer RAS_12 NOTCH3 Any mutation 231 21 TMB quintile 4 -0.22 -1.19 0.72 1466.42 1.00 517 225 15 6 TRUE 0.18
non-small cell lung cancer RAS_12 NOTCH3 Any mutation 396 82 TMB quintile 5 -0.23 -0.80 0.25 1393.31 1.00 773 373 59 23 TRUE 0.42
colorectal cancer RAS_12 NOTCH3 Any mutation 684 199 TMB overall -0.28 -1.81 1.42 1511.46 1.00 1238 651 166 33 TRUE 0.14
non-small cell lung cancer RAS_12 NOTCH3 Any mutation 627 114 TMB overall -0.56 -3.24 2.26 1470.96 1.00 1299 598 85 29 TRUE 0.16
colorectal cancer RAS_12 NOTCH4 Any mutation 275 21 TMB quintile 4 -0.68 -1.65 0.22 1170.62 1.00 483 270 16 5 TRUE 0.79
colorectal cancer RAS_12 NOTCH4 Any mutation 218 37 TMB quintile 5 -0.39 -1.11 0.28 1455.36 1.00 346 207 26 11 TRUE 0.55
colorectal cancer RAS_12 NOTCH4 Any mutation 22 59 TMB quintile 6 -0.39 -1.33 0.56 1414.09 1.00 78 15 52 7 TRUE 0.38
non-small cell lung cancer RAS_12 NOTCH4 Any mutation 231 17 TMB quintile 4 -0.75 -1.91 0.26 1351.24 1.00 514 228 14 3 TRUE 0.78
non-small cell lung cancer RAS_12 NOTCH4 Any mutation 395 107 TMB quintile 5 -0.29 -0.74 0.14 1247.35 1.00 749 366 78 29 TRUE 0.68
colorectal cancer RAS_12 NOTCH4 Any mutation 515 117 TMB overall -0.49 -2.06 1.05 1495.15 1.00 907 492 94 23 TRUE 0.28
non-small cell lung cancer RAS_12 NOTCH4 Any mutation 626 124 TMB overall -0.51 -2.24 1.08 1091.97 1.00 1263 594 92 32 TRUE 0.28
non-small cell lung cancer RAS_12 KEAP1 Any mutation 75 12 TMB quintile 2 0.52 -0.58 1.54 1394.97 1.00 358 71 8 4 FALSE 0.48
non-small cell lung cancer RAS_12 KEAP1 Any mutation 130 50 TMB quintile 3 0.65 0.06 1.23 1428.56 1.00 463 113 33 17 FALSE 1.50
non-small cell lung cancer RAS_12 KEAP1 Any mutation 233 129 TMB quintile 4 0.50 0.12 0.85 1443.46 1.00 455 182 78 51 FALSE 2.08
non-small cell lung cancer RAS_12 KEAP1 Any mutation 400 336 TMB quintile 5 -0.18 -0.46 0.09 1450.88 1.00 602 303 239 97 FALSE 0.71
non-small cell lung cancer RAS_12 KEAP1 Any mutation 838 527 TMB overall 0.37 -0.65 1.39 1375.84 1.00 1878 669 358 169 FALSE 0.33
non-small cell lung cancer RAS_12 KDM5C Any mutation 231 16 TMB quintile 4 -0.19 -1.23 0.67 1475.90 1.00 519 227 12 4 FALSE 0.16
non-small cell lung cancer RAS_12 KDM5C Any mutation 398 70 TMB quintile 5 0.26 -0.23 0.77 1641.43 1.00 787 371 43 27 FALSE 0.51
non-small cell lung cancer RAS_12 KDM5C Any mutation 629 86 TMB overall 0.06 -1.31 1.24 1572.48 1.00 1306 598 55 31 FALSE 0.03
non-small cell lung cancer RAS_12 CDKN2A Any mutation 130 33 TMB quintile 3 0.41 -0.33 1.17 1457.73 1.00 475 119 22 11 TRUE 0.54
non-small cell lung cancer RAS_12 CDKN2A Any mutation 231 43 TMB quintile 4 -0.26 -0.93 0.36 1332.85 1.00 500 220 32 11 TRUE 0.38
non-small cell lung cancer RAS_12 CDKN2A Any mutation 402 178 TMB quintile 5 -0.71 -1.12 -0.34 1370.54 1.00 694 367 143 35 TRUE 3.52
pancreatic cancer RAS_12 CDKN2A Any mutation 252 34 TMB quintile 2 0.85 0.17 1.69 1469.34 1.00 90 222 4 30 TRUE 1.66
pancreatic cancer RAS_12 CDKN2A Any mutation 427 146 TMB quintile 3 1.20 0.68 1.75 1467.86 1.00 91 294 13 133 TRUE 4.87
pancreatic cancer RAS_12 CDKN2A Any mutation 223 96 TMB quintile 4 1.24 0.68 1.86 1498.72 1.00 54 138 11 85 TRUE 4.30
non-small cell lung cancer RAS_12 CDKN2A Any mutation 763 254 TMB overall -0.20 -1.22 0.79 1453.14 1.00 1669 706 197 57 TRUE 0.16
pancreatic cancer RAS_12 CDKN2A Any mutation 902 276 TMB overall 1.10 0.37 1.89 1459.11 1.00 235 654 28 248 TRUE 2.41
non-small cell lung cancer RAS_12 EPHB1 Any mutation 231 19 TMB quintile 4 0.16 -0.78 1.10 1438.91 1.00 519 224 12 7 FALSE 0.12
non-small cell lung cancer RAS_12 EPHB1 Any mutation 398 117 TMB quintile 5 -0.69 -1.13 -0.24 1420.42 1.00 738 374 93 24 FALSE 2.46
non-small cell lung cancer RAS_12 EPHB1 Any mutation 629 152 TMB overall -0.68 -3.70 2.32 1450.06 1.00 1266 598 121 31 FALSE 0.19
uterine cancer RAS_12 PPP2R1A Any mutation 24 44 TMB quintile 3 -0.43 -1.49 0.55 1457.77 1.00 178 20 40 4 FALSE 0.38
uterine cancer RAS_12 PPP2R1A Any mutation 40 46 TMB quintile 4 -0.52 -1.41 0.27 1554.66 1.00 150 34 40 6 FALSE 0.64
uterine cancer RAS_12 PPP2R1A Any mutation 52 25 TMB quintile 5 -0.76 -1.85 0.23 1631.00 1.00 188 49 22 3 FALSE 0.82
uterine cancer RAS_12 PPP2R1A Any mutation 118 145 TMB overall -0.71 -1.86 0.32 1512.00 1.00 558 105 132 13 FALSE 0.71
colorectal cancer RAS_12 ERBB3 Any mutation 283 27 TMB quintile 4 0.10 -0.71 0.88 1383.81 1.00 493 272 16 11 TRUE 0.10
colorectal cancer RAS_12 ERBB3 Any mutation 233 39 TMB quintile 5 -0.11 -0.79 0.57 1457.58 1.00 369 219 25 14 TRUE 0.13
colorectal cancer RAS_12 ERBB3 Any mutation 20 51 TMB quintile 6 -0.72 -1.89 0.28 1179.63 1.00 86 16 47 4 TRUE 0.73
colorectal cancer RAS_12 ERBB3 Any mutation 536 117 TMB overall -0.26 -1.89 1.16 1436.86 1.00 948 507 88 29 TRUE 0.14
colorectal cancer RAS_12 SMAD4 Any mutation 148 51 TMB quintile 3 0.21 -0.29 0.74 1535.77 1.00 309 129 32 19 TRUE 0.36
colorectal cancer RAS_12 SMAD4 Any mutation 284 129 TMB quintile 4 0.15 -0.20 0.51 1370.50 1.00 434 234 79 50 TRUE 0.38
colorectal cancer RAS_12 SMAD4 Any mutation 241 138 TMB quintile 5 0.12 -0.24 0.48 1623.03 1.00 318 187 84 54 TRUE 0.28
colorectal cancer RAS_12 SMAD4 Any mutation 21 31 TMB quintile 6 -0.07 -0.84 0.63 1378.64 1.00 100 17 27 4 TRUE 0.06
non-small cell lung cancer RAS_12 SMAD4 Any mutation 130 21 TMB quintile 3 -0.45 -1.18 0.23 1581.37 1.00 478 127 18 3 TRUE 0.65
non-small cell lung cancer RAS_12 SMAD4 Any mutation 231 36 TMB quintile 4 -0.40 -1.03 0.20 1453.57 1.00 507 223 28 8 TRUE 0.68
non-small cell lung cancer RAS_12 SMAD4 Any mutation 396 49 TMB quintile 5 -0.36 -0.89 0.17 1505.68 1.00 791 383 36 13 TRUE 0.74
pancreatic cancer RAS_12 SMAD4 Any mutation 252 37 TMB quintile 2 0.36 -0.28 1.08 1404.63 1.00 88 221 6 31 TRUE 0.52
pancreatic cancer RAS_12 SMAD4 Any mutation 422 119 TMB quintile 3 0.27 -0.20 0.71 1354.41 1.00 84 324 21 98 TRUE 0.60
pancreatic cancer RAS_12 SMAD4 Any mutation 217 82 TMB quintile 4 0.45 -0.09 1.02 1212.18 1.00 50 150 15 67 TRUE 0.94
pancreatic cancer RAS_12 SMAD4 Any mutation 35 25 TMB quintile 5 0.59 -0.19 1.34 1532.14 1.00 15 18 8 17 TRUE 0.82
colorectal cancer RAS_12 SMAD4 Any mutation 694 349 TMB overall 0.09 -0.50 0.64 1357.38 1.00 1161 567 222 127 TRUE 0.13
non-small cell lung cancer RAS_12 SMAD4 Any mutation 757 106 TMB overall -0.41 -1.08 0.22 1480.93 1.00 1776 733 82 24 TRUE 0.69
pancreatic cancer RAS_12 SMAD4 Any mutation 926 263 TMB overall 0.41 -0.31 1.16 1165.33 1.00 237 713 50 213 TRUE 0.58
colorectal cancer RAS_12 ATM Any mutation 285 46 TMB quintile 4 0.26 -0.33 0.85 1173.13 1.00 485 265 26 20 TRUE 0.41
colorectal cancer RAS_12 ATM Any mutation 238 78 TMB quintile 5 -0.10 -0.58 0.39 1515.69 1.00 347 210 50 28 TRUE 0.16
colorectal cancer RAS_12 ATM Any mutation 22 94 TMB quintile 6 -0.68 -1.55 0.17 1565.90 1.00 73 14 86 8 TRUE 0.94
non-small cell lung cancer RAS_12 ATM Any mutation 75 15 TMB quintile 2 0.83 -0.03 1.65 1481.87 1.00 357 70 10 5 TRUE 1.30
non-small cell lung cancer RAS_12 ATM Any mutation 130 20 TMB quintile 3 0.83 0.07 1.57 1320.57 1.00 484 122 12 8 TRUE 1.56
non-small cell lung cancer RAS_12 ATM Any mutation 239 76 TMB quintile 4 1.28 0.84 1.74 1572.61 1.00 503 194 31 45 TRUE 7.60
non-small cell lung cancer RAS_12 ATM Any mutation 409 166 TMB quintile 5 0.70 0.38 1.03 1404.03 1.00 744 333 90 76 TRUE 4.60
uterine cancer RAS_12 ATM Any mutation 53 46 TMB quintile 5 -0.23 -1.15 0.58 1538.51 1.00 180 45 38 8 TRUE 0.23
colorectal cancer RAS_12 ATM Any mutation 545 218 TMB overall -0.15 -1.71 1.51 1465.13 1.00 905 489 162 56 TRUE 0.07
non-small cell lung cancer RAS_12 ATM Any mutation 853 277 TMB overall 0.91 0.20 1.59 1522.40 1.00 2088 719 143 134 TRUE 1.93
uterine cancer RAS_12 ATM Any mutation 57 147 TMB overall -0.34 -3.03 2.80 1381.90 1.00 200 46 136 11 TRUE 0.09
non-small cell lung cancer RAS_12 RB1 Any mutation 130 33 TMB quintile 3 -1.33 -2.32 -0.53 1427.95 1.00 465 128 31 2 TRUE 2.51
non-small cell lung cancer RAS_12 RB1 Any mutation 231 50 TMB quintile 4 -1.25 -1.99 -0.61 1349.62 1.00 487 225 44 6 TRUE 3.29
non-small cell lung cancer RAS_12 RB1 Any mutation 396 124 TMB quintile 5 -1.09 -1.58 -0.61 1457.68 1.00 727 377 105 19 TRUE 4.94
non-small cell lung cancer RAS_12 RB1 Any mutation 757 207 TMB overall -1.22 -2.03 -0.52 1149.76 1.01 1679 730 180 27 TRUE 3.05
cancer of unknown primary RAS_12 KMT2D Any mutation 34 14 TMB quintile 3 -1.44 -3.23 0.04 1337.99 1.00 98 33 13 1 FALSE 1.08
cancer of unknown primary RAS_12 KMT2D Any mutation 35 11 TMB quintile 4 -0.24 -1.66 1.08 1365.82 1.00 99 32 8 3 FALSE 0.14
cancer of unknown primary RAS_12 KMT2D Any mutation 35 67 TMB quintile 5 -0.89 -1.79 -0.10 1465.87 1.00 103 28 60 7 FALSE 1.37
colorectal cancer RAS_12 KMT2D Any mutation 282 27 TMB quintile 4 -0.53 -1.42 0.27 1594.19 1.00 490 275 20 7 FALSE 0.65
colorectal cancer RAS_12 KMT2D Any mutation 239 104 TMB quintile 5 -0.58 -1.07 -0.10 1400.11 1.00 339 212 77 27 FALSE 1.78
colorectal cancer RAS_12 KMT2D Any mutation 34 245 TMB quintile 6 -0.23 -1.32 1.05 1416.71 1.00 16 3 214 31 FALSE 0.15
non-small cell lung cancer RAS_12 KMT2D Any mutation 130 15 TMB quintile 3 0.05 -1.20 1.15 1606.11 1.00 485 126 11 4 FALSE 0.03
non-small cell lung cancer RAS_12 KMT2D Any mutation 231 42 TMB quintile 4 -0.26 -0.98 0.41 1383.15 1.00 503 220 31 11 FALSE 0.33
non-small cell lung cancer RAS_12 KMT2D Any mutation 400 251 TMB quintile 5 -0.75 -1.08 -0.41 1501.29 1.00 663 350 201 50 FALSE 4.72
uterine cancer RAS_12 KMT2D Any mutation 40 14 TMB quintile 4 -0.54 -2.22 0.82 1613.80 1.00 178 38 12 2 FALSE 0.31
uterine cancer RAS_12 KMT2D Any mutation 54 129 TMB quintile 5 -0.60 -1.26 0.05 1309.47 1.00 123 36 111 18 FALSE 1.20
cancer of unknown primary RAS_12 KMT2D Any mutation 109 123 TMB overall -0.74 -2.32 0.88 1404.13 1.00 303 94 108 15 FALSE 0.45
colorectal cancer RAS_12 KMT2D Any mutation 555 376 TMB overall -0.46 -2.89 2.11 1427.20 1.00 845 490 311 65 FALSE 0.15
non-small cell lung cancer RAS_12 KMT2D Any mutation 761 320 TMB overall -0.52 -2.33 1.18 1511.26 1.00 1659 696 255 65 FALSE 0.26
uterine cancer RAS_12 KMT2D Any mutation 98 252 TMB overall -0.59 -2.83 1.56 1588.87 1.00 318 75 229 23 FALSE 0.23
colorectal cancer RAS_12 TSC2 Any mutation 236 42 TMB quintile 5 -0.45 -1.16 0.20 1525.73 1.00 367 224 30 12 TRUE 0.72
colorectal cancer RAS_12 TSC2 Any mutation 21 56 TMB quintile 6 -0.03 -0.93 0.85 1644.13 1.00 85 13 48 8 TRUE 0.02
colorectal cancer RAS_12 TSC2 Any mutation 257 98 TMB overall -0.21 -2.62 2.03 1641.21 1.00 452 237 78 20 TRUE 0.07
colorectal cancer RAS_12 APC Any mutation 18 78 TMB quintile 2 -0.88 -1.77 -0.10 1260.65 1.00 55 13 73 5 TRUE 1.40
colorectal cancer RAS_12 APC Any mutation 176 428 TMB quintile 3 -0.16 -0.52 0.22 1248.02 1.00 106 52 304 124 TRUE 0.40
colorectal cancer RAS_12 APC Any mutation 395 966 TMB quintile 4 -0.08 -0.42 0.27 1529.70 1.00 94 58 629 337 TRUE 0.19
colorectal cancer RAS_12 APC Any mutation 379 822 TMB quintile 5 0.40 0.03 0.75 1599.35 1.00 104 47 490 332 TRUE 1.56
colorectal cancer RAS_12 APC Any mutation 42 225 TMB quintile 6 0.24 -0.45 0.98 1473.02 1.00 43 4 187 38 TRUE 0.28
non-small cell lung cancer RAS_12 APC Any mutation 130 20 TMB quintile 3 -0.23 -1.12 0.71 1582.72 1.00 481 125 15 5 TRUE 0.21
non-small cell lung cancer RAS_12 APC Any mutation 231 31 TMB quintile 4 -0.99 -1.93 -0.22 1370.37 1.00 503 228 28 3 TRUE 1.57
non-small cell lung cancer RAS_12 APC Any mutation 399 101 TMB quintile 5 -0.37 -0.83 0.06 1511.47 1.00 758 373 75 26 TRUE 1.00
uterine cancer RAS_12 APC Any mutation 52 35 TMB quintile 5 -0.24 -1.28 0.63 1448.60 1.00 190 46 29 6 TRUE 0.21
colorectal cancer RAS_12 APC Any mutation 1010 2519 TMB overall -0.10 -0.76 0.54 1440.22 1.00 402 174 1683 836 TRUE 0.11
non-small cell lung cancer RAS_12 APC Any mutation 760 152 TMB overall -0.53 -1.40 0.38 1319.67 1.00 1742 726 118 34 TRUE 0.63
uterine cancer RAS_12 APC Any mutation 57 119 TMB overall -0.01 -2.79 3.00 1454.78 1.00 220 47 109 10 TRUE 0.00
colorectal cancer RAS_12 ERBB2 Any mutation 282 17 TMB quintile 4 -0.68 -1.75 0.32 1480.80 1.00 496 278 13 4 TRUE 0.69
colorectal cancer RAS_12 ERBB2 Any mutation 233 33 TMB quintile 5 -0.82 -1.68 -0.04 1405.70 1.00 367 226 26 7 TRUE 1.29
colorectal cancer RAS_12 ERBB2 Any mutation 20 42 TMB quintile 6 0.20 -0.81 1.17 1625.72 1.00 95 13 35 7 TRUE 0.16
non-small cell lung cancer RAS_12 ERBB2 Any mutation 75 14 TMB quintile 2 -2.88 -4.45 -1.53 1513.45 1.00 352 75 14 0 TRUE 3.89
non-small cell lung cancer RAS_12 ERBB2 Any mutation 130 27 TMB quintile 3 -2.60 -4.14 -1.31 1452.42 1.00 471 128 25 2 TRUE 3.64
non-small cell lung cancer RAS_12 ERBB2 Any mutation 231 32 TMB quintile 4 -2.97 -4.59 -1.75 1583.24 1.00 501 231 32 0 TRUE 4.26
non-small cell lung cancer RAS_12 ERBB2 Any mutation 396 40 TMB quintile 5 -2.88 -4.36 -1.69 1348.67 1.00 791 395 39 1 TRUE 4.53
colorectal cancer RAS_12 ERBB2 Any mutation 535 92 TMB overall -0.45 -1.97 1.08 1423.22 1.00 958 517 74 18 TRUE 0.25
non-small cell lung cancer RAS_12 ERBB2 Any mutation 832 113 TMB overall -2.82 -4.31 -1.66 1412.86 1.00 2115 829 110 3 TRUE 4.68
uterine cancer RAS_12 JAK1 Any mutation 56 88 TMB quintile 5 0.01 -0.62 0.62 1612.69 1.00 160 39 71 17 TRUE 0.01
uterine cancer RAS_12 JAK1 Any mutation 59 140 TMB overall 0.41 -2.23 3.88 1456.48 1.00 188 39 120 20 TRUE 0.11
colorectal cancer RAS_12 ARID2 Any mutation 282 12 TMB quintile 4 -0.64 -1.98 0.59 1447.56 1.00 500 279 9 3 FALSE 0.49
colorectal cancer RAS_12 ARID2 Any mutation 234 31 TMB quintile 5 0.14 -0.62 0.85 1499.15 1.00 376 221 18 13 FALSE 0.15
colorectal cancer RAS_12 ARID2 Any mutation 20 66 TMB quintile 6 -0.42 -1.38 0.46 1353.76 1.00 75 13 59 7 FALSE 0.42
non-small cell lung cancer RAS_12 ARID2 Any mutation 130 19 TMB quintile 3 -0.79 -2.00 0.12 1276.29 1.00 478 129 18 1 FALSE 0.85
non-small cell lung cancer RAS_12 ARID2 Any mutation 231 35 TMB quintile 4 -0.13 -0.82 0.57 1453.13 1.00 509 220 24 11 FALSE 0.15
non-small cell lung cancer RAS_12 ARID2 Any mutation 397 111 TMB quintile 5 -0.22 -0.62 0.20 1438.46 1.00 757 366 80 31 FALSE 0.51
colorectal cancer RAS_12 ARID2 Any mutation 536 109 TMB overall -0.28 -2.22 1.66 1427.54 1.00 951 513 86 23 FALSE 0.11
non-small cell lung cancer RAS_12 ARID2 Any mutation 758 165 TMB overall -0.38 -1.29 0.40 1446.70 1.00 1744 715 122 43 FALSE 0.41
colorectal cancer RAS_12 MTOR Any mutation 282 19 TMB quintile 4 0.95 0.04 1.95 1590.77 1.00 502 270 7 12 TRUE 1.36
colorectal cancer RAS_12 MTOR Any mutation 234 40 TMB quintile 5 -0.23 -0.96 0.42 1286.38 1.01 366 221 27 13 TRUE 0.29
colorectal cancer RAS_12 MTOR Any mutation 22 70 TMB quintile 6 -0.74 -1.76 0.21 1095.70 1.00 76 16 64 6 TRUE 0.83
non-small cell lung cancer RAS_12 MTOR Any mutation 130 14 TMB quintile 3 -0.35 -1.45 0.53 1455.86 1.00 484 128 12 2 TRUE 0.32
non-small cell lung cancer RAS_12 MTOR Any mutation 231 21 TMB quintile 4 -0.42 -1.24 0.36 1396.43 1.00 515 227 17 4 TRUE 0.49
non-small cell lung cancer RAS_12 MTOR Any mutation 398 70 TMB quintile 5 0.09 -0.39 0.55 1419.05 1.00 782 373 45 25 TRUE 0.16
colorectal cancer RAS_12 MTOR Any mutation 538 129 TMB overall 0.00 -1.91 1.94 1555.62 1.00 944 507 98 31 TRUE 0.00
non-small cell lung cancer RAS_12 MTOR Any mutation 759 105 TMB overall -0.22 -1.10 0.58 1511.81 1.00 1781 728 74 31 TRUE 0.22
colorectal cancer RAS_12 NOTCH1 Any mutation 233 48 TMB quintile 5 -1.31 -2.15 -0.56 1274.82 1.00 356 226 41 7 TRUE 2.93
colorectal cancer RAS_12 NOTCH1 Any mutation 28 112 TMB quintile 6 0.39 -0.46 1.35 1427.93 1.00 59 8 92 20 TRUE 0.43
non-small cell lung cancer RAS_12 NOTCH1 Any mutation 231 15 TMB quintile 4 -0.67 -1.81 0.37 1441.33 1.00 519 228 12 3 TRUE 0.64
non-small cell lung cancer RAS_12 NOTCH1 Any mutation 397 97 TMB quintile 5 -0.48 -0.98 -0.01 1512.71 1.00 758 374 74 23 TRUE 1.27
colorectal cancer RAS_12 NOTCH1 Any mutation 261 160 TMB overall -0.42 -3.10 2.54 1670.93 1.00 415 234 133 27 TRUE 0.12
non-small cell lung cancer RAS_12 NOTCH1 Any mutation 628 112 TMB overall -0.56 -2.24 1.17 1641.20 1.00 1277 602 86 26 TRUE 0.30
colorectal cancer RAS_12 SETD2 Any mutation 147 11 TMB quintile 3 -2.84 -6.05 -0.76 1461.60 1.00 330 147 11 0 FALSE 1.49
colorectal cancer RAS_12 SETD2 Any mutation 233 31 TMB quintile 5 -1.93 -3.23 -0.83 1485.33 1.00 368 230 28 3 FALSE 2.81
colorectal cancer RAS_12 SETD2 Any mutation 22 64 TMB quintile 6 -1.14 -2.22 -0.20 1432.72 1.00 78 17 59 5 FALSE 1.50
non-small cell lung cancer RAS_12 SETD2 Any mutation 75 14 TMB quintile 2 -0.87 -2.30 0.15 1569.97 1.00 352 75 14 0 FALSE 0.77
non-small cell lung cancer RAS_12 SETD2 Any mutation 131 22 TMB quintile 3 -0.72 -1.74 0.17 1490.42 1.00 481 129 20 2 FALSE 0.83
non-small cell lung cancer RAS_12 SETD2 Any mutation 232 59 TMB quintile 4 -0.27 -0.84 0.25 1474.83 1.00 495 217 44 15 FALSE 0.48
non-small cell lung cancer RAS_12 SETD2 Any mutation 403 110 TMB quintile 5 0.05 -0.36 0.45 1553.32 1.00 764 365 72 38 FALSE 0.09
colorectal cancer RAS_12 SETD2 Any mutation 402 106 TMB overall -1.92 -4.13 0.00 1539.47 1.00 776 394 98 8 FALSE 1.24
non-small cell lung cancer RAS_12 SETD2 Any mutation 841 205 TMB overall -0.45 -1.31 0.28 1503.03 1.00 2092 786 150 55 FALSE 0.56
non-small cell lung cancer RAS_12 PBRM1 Any mutation 233 21 TMB quintile 4 0.24 -0.55 1.12 1129.43 1.00 520 224 12 9 TRUE 0.24
non-small cell lung cancer RAS_12 PBRM1 Any mutation 396 79 TMB quintile 5 -0.36 -0.93 0.17 1558.69 1.00 776 377 60 19 TRUE 0.74
non-small cell lung cancer RAS_12 PBRM1 Any mutation 629 100 TMB overall -0.07 -1.55 1.39 1267.79 1.00 1296 601 72 28 TRUE 0.03
colorectal cancer RAS_12 EPHA3 Any mutation 283 17 TMB quintile 4 -0.42 -1.46 0.51 1395.08 1.00 497 278 12 5 FALSE 0.41
colorectal cancer RAS_12 EPHA3 Any mutation 233 41 TMB quintile 5 -0.18 -0.84 0.46 1318.79 1.00 367 219 27 14 FALSE 0.23
colorectal cancer RAS_12 EPHA3 Any mutation 20 44 TMB quintile 6 -0.58 -1.74 0.44 1505.82 1.00 91 16 40 4 FALSE 0.55
non-small cell lung cancer RAS_12 EPHA3 Any mutation 130 15 TMB quintile 3 0.48 -0.68 1.50 1598.14 1.00 486 125 10 5 FALSE 0.41
non-small cell lung cancer RAS_12 EPHA3 Any mutation 231 28 TMB quintile 4 0.50 -0.28 1.26 1340.17 1.00 515 219 16 12 FALSE 0.71
non-small cell lung cancer RAS_12 EPHA3 Any mutation 403 182 TMB quintile 5 -0.06 -0.39 0.26 1550.65 1.00 713 346 125 57 FALSE 0.13
colorectal cancer RAS_12 EPHA3 Any mutation 536 102 TMB overall -0.40 -1.81 1.20 1420.20 1.00 955 513 79 23 FALSE 0.22
non-small cell lung cancer RAS_12 EPHA3 Any mutation 764 237 TMB overall 0.02 -1.83 1.82 1635.30 1.00 1722 690 163 74 FALSE 0.01
non-small cell lung cancer RAS_12 KDR Any mutation 231 21 TMB quintile 4 0.53 -0.24 1.37 1393.03 1.00 520 221 11 10 TRUE 0.68
non-small cell lung cancer RAS_12 KDR Any mutation 399 109 TMB quintile 5 -0.17 -0.63 0.25 1581.58 1.00 751 368 78 31 TRUE 0.36
non-small cell lung cancer RAS_12 KDR Any mutation 630 130 TMB overall 0.14 -1.46 1.93 1419.82 1.00 1271 589 89 41 TRUE 0.06
colorectal cancer RAS_12 PTCH1 Any mutation 233 35 TMB quintile 5 -1.17 -2.09 -0.36 1301.98 1.00 366 227 29 6 TRUE 2.07
colorectal cancer RAS_12 PTCH1 Any mutation 21 99 TMB quintile 6 -0.49 -1.39 0.40 1612.07 1.00 63 11 89 10 TRUE 0.57
colorectal cancer RAS_12 PTCH1 Any mutation 254 134 TMB overall -0.78 -3.35 1.80 1481.29 1.00 429 238 118 16 TRUE 0.27
colorectal cancer RAS_12 TET1 Any mutation 218 26 TMB quintile 5 -0.96 -1.99 -0.06 1284.85 1.00 352 213 21 5 FALSE 1.30
colorectal cancer RAS_12 TET1 Any mutation 21 67 TMB quintile 6 -0.24 -1.16 0.66 1511.15 1.00 82 13 59 8 FALSE 0.22
non-small cell lung cancer RAS_12 TET1 Any mutation 231 16 TMB quintile 4 -0.81 -2.32 0.35 1404.74 1.00 515 228 13 3 FALSE 0.64
non-small cell lung cancer RAS_12 TET1 Any mutation 397 89 TMB quintile 5 -0.18 -0.69 0.28 1444.17 1.00 767 371 63 26 FALSE 0.34
colorectal cancer RAS_12 TET1 Any mutation 239 93 TMB overall -0.58 -2.96 1.82 1461.91 1.00 434 226 80 13 FALSE 0.20
non-small cell lung cancer RAS_12 TET1 Any mutation 628 120 TMB overall -0.87 -3.85 2.39 1521.71 1.00 1287 599 91 29 FALSE 0.25
uterine cancer RAS_12 FGFR2 Any mutation 40 23 TMB quintile 4 -1.61 -3.35 -0.11 1343.10 1.00 169 38 21 2 TRUE 1.31
uterine cancer RAS_12 FGFR2 Any mutation 52 52 TMB quintile 5 -2.54 -4.44 -1.24 1361.07 1.00 165 51 51 1 TRUE 2.83
uterine cancer RAS_12 FGFR2 Any mutation 94 93 TMB overall -2.12 -4.11 -0.41 1482.10 1.00 380 91 90 3 TRUE 1.72
non-small cell lung cancer RAS_12 TBX3 Any mutation 231 11 TMB quintile 4 0.01 -1.21 1.16 1514.49 1.00 524 227 7 4 FALSE 0.01
non-small cell lung cancer RAS_12 TBX3 Any mutation 396 108 TMB quintile 5 -0.22 -0.66 0.22 1695.43 1.00 757 366 78 30 FALSE 0.48
non-small cell lung cancer RAS_12 TBX3 Any mutation 627 119 TMB overall -0.09 -1.93 1.89 1293.03 1.00 1281 593 85 34 FALSE 0.03
colorectal cancer RAS_12 SMAD3 Any mutation 147 12 TMB quintile 3 -0.37 -1.52 0.68 1474.43 1.00 330 145 10 2 TRUE 0.29
colorectal cancer RAS_12 SMAD3 Any mutation 285 27 TMB quintile 4 0.25 -0.44 0.91 1441.58 1.00 496 273 15 12 TRUE 0.33
colorectal cancer RAS_12 SMAD3 Any mutation 239 44 TMB quintile 5 0.49 -0.09 1.05 1347.24 1.00 372 217 22 22 TRUE 1.04
colorectal cancer RAS_12 SMAD3 Any mutation 21 23 TMB quintile 6 0.42 -0.61 1.30 1325.44 1.00 105 16 18 5 TRUE 0.40
colorectal cancer RAS_12 SMAD3 Any mutation 692 106 TMB overall 0.19 -0.76 1.10 1453.36 1.00 1303 651 65 41 TRUE 0.17
non-small cell lung cancer RAS_12 NTRK3 Any mutation 233 31 TMB quintile 4 1.16 0.47 1.90 1334.07 1.00 519 215 13 18 FALSE 2.77
non-small cell lung cancer RAS_12 NTRK3 Any mutation 400 144 TMB quintile 5 0.08 -0.30 0.46 1446.88 1.00 741 351 95 49 FALSE 0.18
non-small cell lung cancer RAS_12 NTRK3 Any mutation 633 195 TMB overall -0.03 -3.11 2.87 1507.32 1.00 1267 566 128 67 FALSE 0.01
colorectal cancer RAS_12 GRIN2A Any mutation 282 30 TMB quintile 4 -0.38 -1.16 0.34 1464.91 1.00 488 273 21 9 FALSE 0.50
colorectal cancer RAS_12 GRIN2A Any mutation 234 42 TMB quintile 5 -0.36 -1.04 0.26 1296.58 1.00 364 221 29 13 FALSE 0.55
colorectal cancer RAS_12 GRIN2A Any mutation 20 59 TMB quintile 6 -1.27 -2.46 -0.22 1360.04 1.00 79 17 56 3 FALSE 1.58
non-small cell lung cancer RAS_12 GRIN2A Any mutation 130 17 TMB quintile 3 0.13 -0.76 0.96 1430.70 1.00 484 125 12 5 FALSE 0.11
non-small cell lung cancer RAS_12 GRIN2A Any mutation 231 39 TMB quintile 4 -0.01 -0.67 0.58 1445.47 1.00 505 219 27 12 FALSE 0.01
non-small cell lung cancer RAS_12 GRIN2A Any mutation 400 124 TMB quintile 5 -0.14 -0.54 0.25 1426.51 1.00 744 364 88 36 FALSE 0.32
colorectal cancer RAS_12 GRIN2A Any mutation 536 131 TMB overall -0.62 -2.20 0.92 1409.85 1.00 931 511 106 25 FALSE 0.38
non-small cell lung cancer RAS_12 GRIN2A Any mutation 761 180 TMB overall -0.01 -0.86 0.84 1449.17 1.00 1733 708 127 53 FALSE 0.01
uterine cancer RAS_12 CTCF Any mutation 40 12 TMB quintile 4 0.15 -1.32 1.41 1389.92 1.00 180 37 9 3 FALSE 0.09
uterine cancer RAS_12 CTCF Any mutation 54 103 TMB quintile 5 0.02 -0.58 0.60 1432.65 1.00 133 33 82 21 FALSE 0.02
uterine cancer RAS_12 CTCF Any mutation 96 163 TMB overall -0.19 -2.32 1.89 1492.04 1.00 339 71 138 25 FALSE 0.07
non-small cell lung cancer RAS_12 STK11 Any mutation 75 12 TMB quintile 2 1.46 0.53 2.51 1531.69 1.00 361 68 5 7 TRUE 2.39
non-small cell lung cancer RAS_12 STK11 Any mutation 132 78 TMB quintile 3 1.19 0.69 1.67 1403.06 1.00 451 99 45 33 TRUE 5.96
non-small cell lung cancer RAS_12 STK11 Any mutation 234 161 TMB quintile 4 1.46 1.10 1.83 1393.31 1.00 462 142 69 92 TRUE 14.45
non-small cell lung cancer RAS_12 STK11 Any mutation 400 283 TMB quintile 5 0.22 -0.07 0.49 1463.30 1.00 654 300 183 100 TRUE 0.89
non-small cell lung cancer RAS_12 STK11 Any mutation 841 534 TMB overall 1.08 0.15 2.03 1505.13 1.00 1928 609 302 232 TRUE 1.67
colorectal cancer RAS_12 ASXL1 Any mutation 282 15 TMB quintile 4 -0.01 -1.07 0.93 1426.24 1.00 500 276 9 6 TRUE 0.01
colorectal cancer RAS_12 ASXL1 Any mutation 233 30 TMB quintile 5 -0.52 -1.39 0.28 1569.32 1.00 372 225 22 8 TRUE 0.66
colorectal cancer RAS_12 ASXL1 Any mutation 22 57 TMB quintile 6 -0.12 -1.03 0.75 1326.72 1.00 80 14 49 8 TRUE 0.10
colorectal cancer RAS_12 ASXL1 Any mutation 537 102 TMB overall -0.20 -1.84 1.37 1610.71 1.00 952 515 80 22 TRUE 0.09
colorectal cancer RAS_12 EP300 Any mutation 233 39 TMB quintile 5 -0.76 -1.58 -0.04 1551.29 1.00 365 224 30 9 TRUE 1.27
colorectal cancer RAS_12 EP300 Any mutation 23 72 TMB quintile 6 -0.31 -1.20 0.54 1421.08 1.00 78 14 63 9 TRUE 0.31
non-small cell lung cancer RAS_12 EP300 Any mutation 397 77 TMB quintile 5 -0.28 -0.84 0.22 995.37 1.00 776 376 56 21 TRUE 0.54
uterine cancer RAS_12 EP300 Any mutation 53 39 TMB quintile 5 0.00 -0.91 0.78 1573.62 1.00 182 45 31 8 TRUE 0.00
colorectal cancer RAS_12 EP300 Any mutation 256 111 TMB overall -0.45 -2.84 2.30 1365.80 1.00 443 238 93 18 TRUE 0.15
non-small cell lung cancer RAS_12 EP300 Any mutation 397 77 TMB overall -0.21 -4.01 4.03 1360.93 1.00 776 376 56 21 TRUE 0.04
uterine cancer RAS_12 EP300 Any mutation 56 92 TMB overall -0.02 -2.75 3.01 1599.06 1.00 213 46 82 10 TRUE 0.01
colorectal cancer RAS_12 ERBB4 Any mutation 282 22 TMB quintile 4 -0.08 -0.92 0.77 1636.68 1.00 496 274 14 8 TRUE 0.06
colorectal cancer RAS_12 ERBB4 Any mutation 234 45 TMB quintile 5 0.10 -0.55 0.71 1452.79 1.00 367 216 27 18 TRUE 0.13
colorectal cancer RAS_12 ERBB4 Any mutation 21 61 TMB quintile 6 -0.06 -0.97 0.80 1393.46 1.00 84 13 53 8 TRUE 0.05
non-small cell lung cancer RAS_12 ERBB4 Any mutation 231 25 TMB quintile 4 -0.03 -0.92 0.80 1637.57 1.00 514 223 17 8 TRUE 0.02
non-small cell lung cancer RAS_12 ERBB4 Any mutation 400 148 TMB quintile 5 -0.65 -1.08 -0.25 1527.82 1.00 731 369 117 31 TRUE 2.63
colorectal cancer RAS_12 ERBB4 Any mutation 537 128 TMB overall -0.01 -1.65 1.56 1493.19 1.00 947 503 94 34 TRUE 0.01
non-small cell lung cancer RAS_12 ERBB4 Any mutation 631 185 TMB overall -0.58 -3.34 2.19 1407.24 1.00 1254 592 146 39 TRUE 0.17
colorectal cancer RAS_12 MED12 Any mutation 283 18 TMB quintile 4 0.43 -0.46 1.34 1530.44 1.00 500 274 9 9 TRUE 0.46
colorectal cancer RAS_12 MED12 Any mutation 233 28 TMB quintile 5 0.04 -0.76 0.80 1489.45 1.00 378 222 17 11 TRUE 0.04
colorectal cancer RAS_12 MED12 Any mutation 21 59 TMB quintile 6 -0.71 -1.77 0.21 1624.33 1.00 79 16 54 5 TRUE 0.77
non-small cell lung cancer RAS_12 MED12 Any mutation 130 23 TMB quintile 3 -0.36 -1.20 0.44 1455.95 1.00 477 126 19 4 TRUE 0.42
non-small cell lung cancer RAS_12 MED12 Any mutation 231 32 TMB quintile 4 -0.27 -0.96 0.41 1396.88 1.00 508 222 23 9 TRUE 0.35
non-small cell lung cancer RAS_12 MED12 Any mutation 399 101 TMB quintile 5 -0.41 -0.87 0.03 1381.56 1.00 756 375 77 24 TRUE 1.13
uterine cancer RAS_12 MED12 Any mutation 13 13 TMB quintile 2 -1.77 -4.26 0.15 1587.55 1.00 119 13 13 0 TRUE 0.92
uterine cancer RAS_12 MED12 Any mutation 24 16 TMB quintile 3 -0.37 -2.04 1.06 1293.33 1.00 203 22 14 2 TRUE 0.20
uterine cancer RAS_12 MED12 Any mutation 40 20 TMB quintile 4 -1.51 -3.42 -0.03 1355.23 1.00 170 39 19 1 TRUE 1.16
uterine cancer RAS_12 MED12 Any mutation 52 31 TMB quintile 5 -0.26 -1.25 0.69 1367.39 1.00 189 46 25 6 TRUE 0.22
colorectal cancer RAS_12 MED12 Any mutation 537 105 TMB overall -0.05 -1.76 1.79 1269.56 1.00 957 512 80 25 TRUE 0.02
non-small cell lung cancer RAS_12 MED12 Any mutation 760 156 TMB overall -0.35 -1.10 0.39 1385.83 1.00 1741 723 119 37 TRUE 0.44
uterine cancer RAS_12 MED12 Any mutation 131 138 TMB overall -1.18 -2.70 0.27 1412.73 1.00 712 122 129 9 TRUE 0.94
non-small cell lung cancer RAS_12 RBM10 Any mutation 75 29 TMB quintile 2 0.25 -0.44 0.85 1544.67 1.00 342 70 24 5 FALSE 0.35
non-small cell lung cancer RAS_12 RBM10 Any mutation 130 46 TMB quintile 3 0.36 -0.22 0.87 1486.67 1.00 463 118 34 12 FALSE 0.71
non-small cell lung cancer RAS_12 RBM10 Any mutation 232 90 TMB quintile 4 0.73 0.33 1.12 1086.91 1.00 483 190 48 42 FALSE 3.50
non-small cell lung cancer RAS_12 RBM10 Any mutation 403 200 TMB quintile 5 0.65 0.35 0.93 1358.26 1.00 727 314 111 89 FALSE 4.92
non-small cell lung cancer RAS_12 RBM10 Any mutation 840 365 TMB overall 0.51 0.01 1.02 1494.55 1.00 2015 692 217 148 FALSE 1.33
colorectal cancer RAS_12 NF1 Any mutation 282 13 TMB quintile 4 -1.84 -3.79 -0.32 1422.87 1.00 498 281 12 1 TRUE 1.43
colorectal cancer RAS_12 NF1 Any mutation 234 34 TMB quintile 5 -0.18 -0.93 0.52 1387.51 1.00 371 222 22 12 TRUE 0.20
colorectal cancer RAS_12 NF1 Any mutation 21 86 TMB quintile 6 -0.78 -1.76 0.15 1547.37 1.00 75 14 79 7 TRUE 0.98
non-small cell lung cancer RAS_12 NF1 Any mutation 130 25 TMB quintile 3 -0.97 -2.03 0.01 1431.61 1.00 475 127 22 3 TRUE 1.20
non-small cell lung cancer RAS_12 NF1 Any mutation 231 59 TMB quintile 4 -1.48 -2.34 -0.74 1384.89 1.00 485 226 54 5 TRUE 3.65
non-small cell lung cancer RAS_12 NF1 Any mutation 400 216 TMB quintile 5 -0.82 -1.18 -0.45 1570.45 1.00 684 359 175 41 TRUE 4.93
uterine cancer RAS_12 NF1 Any mutation 52 38 TMB quintile 5 -0.65 -1.78 0.30 1354.41 1.00 184 47 33 5 TRUE 0.67
colorectal cancer RAS_12 NF1 Any mutation 537 133 TMB overall -0.87 -2.91 1.15 1647.52 1.00 944 517 113 20 TRUE 0.42
non-small cell lung cancer RAS_12 NF1 Any mutation 761 300 TMB overall -1.08 -2.09 0.01 1339.83 1.00 1644 712 251 49 TRUE 1.39
uterine cancer RAS_12 NF1 Any mutation 54 111 TMB overall -0.82 -3.82 2.42 1523.41 1.00 212 48 105 6 TRUE 0.22
non-small cell lung cancer RAS_12 FLT1 Any mutation 231 21 TMB quintile 4 0.51 -0.31 1.33 1587.41 1.00 521 221 11 10 FALSE 0.61
non-small cell lung cancer RAS_12 FLT1 Any mutation 399 99 TMB quintile 5 -0.23 -0.69 0.21 1578.98 1.00 762 372 72 27 FALSE 0.49
non-small cell lung cancer RAS_12 FLT1 Any mutation 630 120 TMB overall 0.14 -1.56 1.81 1534.42 1.00 1283 593 83 37 FALSE 0.06
uterine cancer RAS_12 RASA1 Any mutation 52 25 TMB quintile 5 -0.51 -1.83 0.61 1292.71 1.00 191 48 21 4 FALSE 0.37
uterine cancer RAS_12 RASA1 Any mutation 54 95 TMB overall -1.80 -6.00 1.77 1475.33 1.00 218 50 91 4 FALSE 0.44
colorectal cancer RAS_12 EPHA5 Any mutation 282 18 TMB quintile 4 -0.53 -1.62 0.37 1631.23 1.00 496 277 13 5 FALSE 0.52
colorectal cancer RAS_12 EPHA5 Any mutation 234 52 TMB quintile 5 -0.16 -0.77 0.41 1351.44 1.00 361 216 34 18 FALSE 0.22
colorectal cancer RAS_12 EPHA5 Any mutation 20 66 TMB quintile 6 -0.54 -1.53 0.34 1500.28 1.00 84 14 60 6 FALSE 0.57
non-small cell lung cancer RAS_12 EPHA5 Any mutation 231 48 TMB quintile 4 0.28 -0.34 0.86 1441.02 1.00 502 213 30 18 FALSE 0.44
non-small cell lung cancer RAS_12 EPHA5 Any mutation 400 191 TMB quintile 5 0.04 -0.28 0.35 1336.24 1.00 714 337 128 63 FALSE 0.09
colorectal cancer RAS_12 EPHA5 Any mutation 536 136 TMB overall -0.42 -2.02 1.10 1506.24 1.00 941 507 107 29 FALSE 0.22
non-small cell lung cancer RAS_12 EPHA5 Any mutation 631 250 TMB overall -0.20 -2.65 2.08 1427.79 1.00 1226 550 169 81 FALSE 0.06
colorectal cancer RAS_12 AR Any mutation 282 21 TMB quintile 4 -0.94 -2.02 -0.01 1556.42 1.00 492 278 17 4 TRUE 1.15
colorectal cancer RAS_12 AR Any mutation 233 34 TMB quintile 5 -1.07 -1.99 -0.24 1545.80 1.00 367 227 28 6 TRUE 1.75
colorectal cancer RAS_12 AR Any mutation 20 55 TMB quintile 6 -0.01 -0.97 0.92 1254.79 1.00 85 12 47 8 TRUE 0.01
non-small cell lung cancer RAS_12 AR Any mutation 231 16 TMB quintile 4 0.30 -0.59 1.23 1434.57 1.00 522 224 9 7 TRUE 0.29
non-small cell lung cancer RAS_12 AR Any mutation 399 77 TMB quintile 5 -0.15 -0.69 0.34 1480.89 1.00 777 377 55 22 TRUE 0.24
colorectal cancer RAS_12 AR Any mutation 535 110 TMB overall -0.65 -2.30 0.99 1420.91 1.00 944 517 92 18 TRUE 0.37
non-small cell lung cancer RAS_12 AR Any mutation 630 93 TMB overall 0.07 -1.42 1.67 1629.69 1.00 1299 601 64 29 TRUE 0.03
colorectal cancer RAS_12 ROS1 Any mutation 282 14 TMB quintile 4 -1.46 -3.12 -0.20 1261.22 1.00 497 280 12 2 TRUE 1.39
colorectal cancer RAS_12 ROS1 Any mutation 233 24 TMB quintile 5 -1.01 -2.05 -0.05 1637.77 1.00 374 228 19 5 TRUE 1.28
colorectal cancer RAS_12 ROS1 Any mutation 20 61 TMB quintile 6 -1.85 -3.49 -0.60 1483.22 1.00 85 18 59 2 TRUE 2.01
non-small cell lung cancer RAS_12 ROS1 Any mutation 231 13 TMB quintile 4 -2.84 -7.15 -0.71 1341.98 1.00 518 231 13 0 TRUE 0.99
non-small cell lung cancer RAS_12 ROS1 Any mutation 397 80 TMB quintile 5 -1.14 -1.81 -0.52 1364.95 1.00 763 385 68 12 TRUE 3.32
colorectal cancer RAS_12 ROS1 Any mutation 535 99 TMB overall -1.37 -3.06 0.54 1427.50 1.00 956 526 90 9 TRUE 0.89
non-small cell lung cancer RAS_12 ROS1 Any mutation 628 93 TMB overall -1.87 -5.03 0.36 1557.43 1.00 1281 616 81 12 TRUE 0.80
colorectal cancer RAS_12 PIK3CG Any mutation 282 16 TMB quintile 4 -0.58 -1.67 0.42 1598.88 1.00 497 278 12 4 FALSE 0.55
colorectal cancer RAS_12 PIK3CG Any mutation 233 38 TMB quintile 5 0.04 -0.64 0.73 1365.61 1.00 370 218 23 15 FALSE 0.04
colorectal cancer RAS_12 PIK3CG Any mutation 22 45 TMB quintile 6 -0.40 -1.44 0.46 1417.73 1.00 94 17 40 5 FALSE 0.38
non-small cell lung cancer RAS_12 PIK3CG Any mutation 231 16 TMB quintile 4 0.36 -0.55 1.34 1559.01 1.00 522 224 9 7 FALSE 0.33
non-small cell lung cancer RAS_12 PIK3CG Any mutation 400 150 TMB quintile 5 -0.19 -0.58 0.20 1506.57 1.00 733 358 108 42 FALSE 0.48
colorectal cancer RAS_12 PIK3CG Any mutation 537 99 TMB overall -0.33 -1.91 1.17 1444.32 1.00 961 513 75 24 FALSE 0.17
non-small cell lung cancer RAS_12 PIK3CG Any mutation 631 166 TMB overall 0.08 -1.84 2.22 1411.55 1.00 1255 582 117 49 FALSE 0.03
non-small cell lung cancer RAS_12 EGFR Any mutation 75 200 TMB quintile 2 -5.16 -8.31 -3.39 1438.36 1.00 188 75 200 0 TRUE 4.55
non-small cell lung cancer RAS_12 EGFR Any mutation 130 287 TMB quintile 3 -5.41 -8.23 -3.66 1301.21 1.00 266 130 287 0 TRUE 5.19
non-small cell lung cancer RAS_12 EGFR Any mutation 231 256 TMB quintile 4 -4.45 -5.99 -3.33 1422.67 1.00 341 229 254 2 TRUE 10.72
non-small cell lung cancer RAS_12 EGFR Any mutation 396 175 TMB quintile 5 -2.04 -2.71 -1.47 1457.75 1.00 706 382 161 14 TRUE 9.57
non-small cell lung cancer RAS_12 EGFR Any mutation 832 918 TMB overall -4.21 -5.96 -2.77 1346.59 1.00 1501 816 902 16 TRUE 6.60
colorectal cancer RAS_12 ARID1B Any mutation 282 13 TMB quintile 4 -0.54 -1.81 0.60 1283.46 1.00 501 278 9 4 TRUE 0.42
colorectal cancer RAS_12 ARID1B Any mutation 234 46 TMB quintile 5 -0.98 -1.74 -0.25 1251.51 1.00 358 225 37 9 TRUE 2.01
colorectal cancer RAS_12 ARID1B Any mutation 20 79 TMB quintile 6 -1.50 -2.72 -0.46 1439.21 1.00 65 16 75 4 TRUE 2.02
non-small cell lung cancer RAS_12 ARID1B Any mutation 130 11 TMB quintile 3 -0.40 -1.60 0.64 1481.66 1.00 487 128 9 2 TRUE 0.32
non-small cell lung cancer RAS_12 ARID1B Any mutation 231 16 TMB quintile 4 -0.80 -1.96 0.19 1445.92 1.00 518 229 14 2 TRUE 0.84
non-small cell lung cancer RAS_12 ARID1B Any mutation 398 77 TMB quintile 5 -0.03 -0.54 0.44 1503.49 1.00 778 373 52 25 TRUE 0.05
uterine cancer RAS_12 ARID1B Any mutation 55 59 TMB quintile 5 0.37 -0.27 1.01 1625.11 1.00 172 40 44 15 TRUE 0.56
colorectal cancer RAS_12 ARID1B Any mutation 536 138 TMB overall -0.96 -2.80 0.87 1430.26 1.00 924 519 121 17 TRUE 0.53
non-small cell lung cancer RAS_12 ARID1B Any mutation 759 104 TMB overall -0.40 -1.49 0.58 1505.04 1.00 1783 730 75 29 TRUE 0.37
uterine cancer RAS_12 ARID1B Any mutation 57 107 TMB overall 0.56 -2.26 4.00 1477.01 1.00 202 40 90 17 TRUE 0.14
non-small cell lung cancer RAS_12 MET Any mutation 75 21 TMB quintile 2 -0.87 -2.04 0.06 1378.11 1.00 348 73 19 2 TRUE 1.02
non-small cell lung cancer RAS_12 MET Any mutation 130 30 TMB quintile 3 -1.06 -2.17 -0.20 1593.17 1.00 474 128 28 2 TRUE 1.50
non-small cell lung cancer RAS_12 MET Any mutation 231 34 TMB quintile 4 -1.49 -2.81 -0.56 1538.13 1.00 504 230 33 1 TRUE 2.06
non-small cell lung cancer RAS_12 MET Any mutation 396 47 TMB quintile 5 -0.17 -0.80 0.44 1471.87 1.00 799 379 30 17 TRUE 0.23
non-small cell lung cancer RAS_12 MET Any mutation 832 132 TMB overall -0.89 -1.88 -0.18 1375.80 1.00 2125 810 110 22 TRUE 1.49
colorectal cancer RAS_12 BRAF Any mutation 147 27 TMB quintile 3 -2.48 -4.03 -1.22 1454.73 1.00 314 146 26 1 TRUE 3.31
colorectal cancer RAS_12 BRAF Any mutation 282 60 TMB quintile 4 -2.47 -3.53 -1.55 1485.02 1.00 452 279 57 3 TRUE 5.64
colorectal cancer RAS_12 BRAF Any mutation 234 104 TMB quintile 5 -2.38 -3.11 -1.69 1406.58 1.00 298 227 97 7 TRUE 9.65
colorectal cancer RAS_12 BRAF Any mutation 21 59 TMB quintile 6 -1.94 -3.24 -0.86 1548.50 1.00 74 18 56 3 TRUE 2.86
non-small cell lung cancer RAS_12 BRAF Any mutation 75 11 TMB quintile 2 -1.72 -3.45 -0.43 1479.39 1.00 355 75 11 0 TRUE 1.52
non-small cell lung cancer RAS_12 BRAF Any mutation 130 13 TMB quintile 3 -1.79 -3.54 -0.50 1466.07 1.00 483 130 13 0 TRUE 1.66
non-small cell lung cancer RAS_12 BRAF Any mutation 231 46 TMB quintile 4 -1.23 -2.08 -0.48 1538.94 1.00 492 225 40 6 TRUE 2.61
non-small cell lung cancer RAS_12 BRAF Any mutation 396 101 TMB quintile 5 -0.99 -1.51 -0.50 1419.32 1.00 745 379 84 17 TRUE 3.75
colorectal cancer RAS_12 BRAF Any mutation 684 250 TMB overall -2.29 -3.37 -1.26 1512.17 1.00 1138 670 236 14 TRUE 4.61
non-small cell lung cancer RAS_12 BRAF Any mutation 832 171 TMB overall -1.43 -2.56 -0.51 1451.20 1.00 2075 809 148 23 TRUE 2.24
colorectal cancer RAS_12 B2M Any mutation 222 50 TMB quintile 5 -0.57 -1.27 0.11 1589.97 1.00 349 209 37 13 FALSE 1.03
colorectal cancer RAS_12 B2M Any mutation 26 79 TMB quintile 6 -0.10 -0.88 0.74 1422.38 1.00 75 14 67 12 FALSE 0.09
colorectal cancer RAS_12 B2M Any mutation 248 129 TMB overall -0.34 -2.54 1.84 1595.82 1.00 424 223 104 25 FALSE 0.12
colorectal cancer RAS_12 CARD11 Any mutation 282 28 TMB quintile 4 0.07 -0.70 0.82 1377.22 1.00 492 271 17 11 FALSE 0.07
colorectal cancer RAS_12 CARD11 Any mutation 234 43 TMB quintile 5 -0.23 -0.88 0.38 1664.82 1.00 364 220 29 14 FALSE 0.33
colorectal cancer RAS_12 CARD11 Any mutation 21 52 TMB quintile 6 0.16 -0.71 1.01 1402.17 1.00 88 13 44 8 FALSE 0.14
non-small cell lung cancer RAS_12 CARD11 Any mutation 231 18 TMB quintile 4 0.16 -0.70 1.04 1251.86 1.00 520 224 11 7 FALSE 0.14
non-small cell lung cancer RAS_12 CARD11 Any mutation 398 97 TMB quintile 5 -0.20 -0.70 0.24 1548.35 1.00 761 371 70 27 FALSE 0.42
colorectal cancer RAS_12 CARD11 Any mutation 537 123 TMB overall -0.03 -1.65 1.36 1551.55 1.00 944 504 90 33 FALSE 0.01
non-small cell lung cancer RAS_12 CARD11 Any mutation 629 115 TMB overall -0.05 -1.58 1.69 1426.21 1.00 1281 595 81 34 FALSE 0.02
non-small cell lung cancer RAS_12 INPP4B Any mutation 231 17 TMB quintile 4 0.56 -0.32 1.39 1507.03 1.00 522 223 9 8 FALSE 0.70
non-small cell lung cancer RAS_12 INPP4B Any mutation 399 87 TMB quintile 5 0.56 0.11 1.01 1332.17 1.00 784 361 49 38 FALSE 1.87
non-small cell lung cancer RAS_12 INPP4B Any mutation 630 104 TMB overall 0.55 -0.90 1.93 1480.85 1.00 1306 584 58 46 FALSE 0.37
non-small cell lung cancer RAS_12 NFE2L2 Any mutation 231 31 TMB quintile 4 -0.92 -1.69 -0.17 1572.12 1.00 511 226 26 5 FALSE 1.80
non-small cell lung cancer RAS_12 NFE2L2 Any mutation 397 83 TMB quintile 5 -0.90 -1.45 -0.40 1421.64 1.00 764 383 69 14 FALSE 3.02
non-small cell lung cancer RAS_12 NFE2L2 Any mutation 628 114 TMB overall -0.90 -1.82 0.04 1428.88 1.00 1275 609 95 19 FALSE 1.31
colorectal cancer RAS_12 SOX9 Any mutation 147 17 TMB quintile 3 -0.10 -1.05 0.80 1492.80 1.00 328 142 12 5 FALSE 0.08
colorectal cancer RAS_12 SOX9 Any mutation 286 85 TMB quintile 4 0.24 -0.20 0.68 1302.10 1.00 459 251 50 35 FALSE 0.53
colorectal cancer RAS_12 SOX9 Any mutation 239 107 TMB quintile 5 0.07 -0.38 0.48 1571.04 1.00 333 198 66 41 FALSE 0.12
colorectal cancer RAS_12 SOX9 Any mutation 21 50 TMB quintile 6 0.69 -0.12 1.55 1410.92 1.00 90 10 39 11 FALSE 0.98
colorectal cancer RAS_12 SOX9 Any mutation 693 259 TMB overall 0.22 -0.78 1.23 1315.58 1.00 1210 601 167 92 FALSE 0.19
colorectal cancer RAS_12 SMAD2 Any mutation 282 29 TMB quintile 4 0.31 -0.37 0.94 1593.32 1.00 494 269 16 13 TRUE 0.46
colorectal cancer RAS_12 SMAD2 Any mutation 236 53 TMB quintile 5 0.49 -0.06 1.01 1525.01 1.00 370 210 27 26 TRUE 1.11
colorectal cancer RAS_12 SMAD2 Any mutation 20 16 TMB quintile 6 0.07 -1.17 1.11 1234.96 1.00 111 18 14 2 TRUE 0.04
colorectal cancer RAS_12 SMAD2 Any mutation 538 98 TMB overall 0.29 -0.81 1.32 1299.88 1.00 975 497 57 41 TRUE 0.23
non-small cell lung cancer RAS_12 GLI1 Any mutation 218 16 TMB quintile 4 0.53 -0.34 1.48 1462.81 1.00 456 210 8 8 FALSE 0.60
non-small cell lung cancer RAS_12 GLI1 Any mutation 365 77 TMB quintile 5 0.26 -0.23 0.72 1403.82 1.00 694 336 48 29 FALSE 0.55
non-small cell lung cancer RAS_12 GLI1 Any mutation 583 93 TMB overall 0.39 -1.03 1.71 1635.87 1.00 1150 546 56 37 FALSE 0.23
colorectal cancer RAS_12 ZFHX3 Any mutation 259 14 TMB quintile 4 0.16 -0.91 1.20 1384.94 1.00 453 253 8 6 FALSE 0.12
colorectal cancer RAS_12 ZFHX3 Any mutation 217 63 TMB quintile 5 -0.46 -1.04 0.10 1571.56 1.00 323 199 45 18 FALSE 0.91
colorectal cancer RAS_12 ZFHX3 Any mutation 25 143 TMB quintile 6 0.94 -0.10 2.25 1410.11 1.00 47 3 121 22 FALSE 0.92
non-small cell lung cancer RAS_12 ZFHX3 Any mutation 120 13 TMB quintile 3 -0.81 -2.22 0.25 1647.80 1.00 438 119 12 1 FALSE 0.71
non-small cell lung cancer RAS_12 ZFHX3 Any mutation 217 30 TMB quintile 4 -0.35 -1.07 0.33 1389.85 1.00 440 209 22 8 FALSE 0.48
non-small cell lung cancer RAS_12 ZFHX3 Any mutation 365 112 TMB quintile 5 -0.28 -0.72 0.13 1315.07 1.00 663 334 81 31 FALSE 0.70
uterine cancer RAS_12 ZFHX3 Any mutation 37 13 TMB quintile 4 0.07 -1.26 1.32 1390.28 1.00 158 34 10 3 FALSE 0.04
uterine cancer RAS_12 ZFHX3 Any mutation 52 105 TMB quintile 5 -0.01 -0.63 0.62 1230.35 1.00 135 32 85 20 FALSE 0.02
colorectal cancer RAS_12 ZFHX3 Any mutation 501 220 TMB overall 0.21 -2.01 2.39 1459.60 1.00 823 455 174 46 FALSE 0.07
non-small cell lung cancer RAS_12 ZFHX3 Any mutation 702 155 TMB overall -0.48 -1.51 0.46 1453.56 1.00 1541 662 115 40 FALSE 0.48
uterine cancer RAS_12 ZFHX3 Any mutation 93 210 TMB overall -0.08 -2.18 2.01 1436.72 1.00 317 67 184 26 FALSE 0.03
colorectal cancer RAS_12 MGA Any mutation 259 15 TMB quintile 4 -1.34 -2.76 -0.14 1183.88 1.00 449 257 13 2 FALSE 1.36
colorectal cancer RAS_12 MGA Any mutation 218 46 TMB quintile 5 -0.10 -0.71 0.50 1466.92 1.00 332 201 29 17 FALSE 0.12
colorectal cancer RAS_12 MGA Any mutation 19 58 TMB quintile 6 -0.76 -1.80 0.22 1440.96 1.00 74 14 53 5 FALSE 0.85
non-small cell lung cancer RAS_12 MGA Any mutation 120 14 TMB quintile 3 0.18 -0.86 1.19 1657.47 1.00 441 116 10 4 FALSE 0.14
non-small cell lung cancer RAS_12 MGA Any mutation 217 24 TMB quintile 4 0.16 -0.63 0.92 1556.04 1.00 447 208 15 9 FALSE 0.17
non-small cell lung cancer RAS_12 MGA Any mutation 367 140 TMB quintile 5 -0.01 -0.36 0.35 1478.92 1.00 658 322 95 45 FALSE 0.01
uterine cancer RAS_12 MGA Any mutation 48 24 TMB quintile 5 -1.86 -4.12 -0.25 1561.37 1.00 180 47 23 1 FALSE 1.21
uterine cancer RAS_12 MGA Any mutation 6 82 TMB quintile 6 0.09 -1.68 2.22 1470.54 1.00 23 1 77 5 FALSE 0.03
colorectal cancer RAS_12 MGA Any mutation 496 119 TMB overall -0.72 -2.40 1.00 1483.58 1.00 855 472 95 24 FALSE 0.41
non-small cell lung cancer RAS_12 MGA Any mutation 704 178 TMB overall 0.13 -0.86 1.27 1566.28 1.00 1546 646 120 58 FALSE 0.09
uterine cancer RAS_12 MGA Any mutation 54 106 TMB overall -0.87 -4.05 2.67 1338.87 1.00 203 48 100 6 FALSE 0.21
colorectal cancer RAS_12 KMT2B Any mutation 122 54 TMB quintile 5 -0.19 -0.81 0.39 1488.68 1.00 176 104 36 18 FALSE 0.27
colorectal cancer RAS_12 KMT2B Any mutation 13 115 TMB quintile 6 0.68 -0.91 2.73 1314.83 1.00 21 1 103 12 FALSE 0.33
colorectal cancer RAS_12 KMT2B Any mutation 135 169 TMB overall 0.22 -2.82 3.67 1243.88 1.00 197 105 139 30 FALSE 0.05
colorectal cancer RAS_12 TCF7L2 Any mutation 133 35 TMB quintile 3 0.13 -0.54 0.80 1317.64 1.00 285 121 23 12 FALSE 0.15
colorectal cancer RAS_12 TCF7L2 Any mutation 262 79 TMB quintile 4 0.34 -0.11 0.82 1564.52 1.00 418 227 44 35 FALSE 0.82
colorectal cancer RAS_12 TCF7L2 Any mutation 221 108 TMB quintile 5 0.03 -0.38 0.43 1513.15 1.00 299 180 67 41 FALSE 0.06
colorectal cancer RAS_12 TCF7L2 Any mutation 20 70 TMB quintile 6 0.36 -0.45 1.19 1578.09 1.00 66 8 58 12 FALSE 0.42
colorectal cancer RAS_12 TCF7L2 Any mutation 636 292 TMB overall 0.21 -0.77 1.13 1569.29 1.00 1068 536 192 100 FALSE 0.19
colorectal cancer RAS_12 ANKRD11 Any mutation 252 11 TMB quintile 4 -0.30 -1.57 0.90 1500.55 1.00 443 248 7 4 FALSE 0.20
colorectal cancer RAS_12 ANKRD11 Any mutation 202 43 TMB quintile 5 -1.40 -2.31 -0.59 1461.17 1.00 305 196 37 6 FALSE 2.80
colorectal cancer RAS_12 ANKRD11 Any mutation 22 86 TMB quintile 6 -0.65 -1.58 0.19 1527.16 1.00 62 13 77 9 FALSE 0.83
colorectal cancer RAS_12 ANKRD11 Any mutation 476 140 TMB overall -0.79 -2.84 1.10 1481.92 1.00 810 457 121 19 FALSE 0.36
colorectal cancer RAS_12 POLD1 Any mutation 219 20 TMB quintile 5 -0.22 -1.22 0.68 1551.78 1.00 349 212 13 7 TRUE 0.18
colorectal cancer RAS_12 POLD1 Any mutation 20 83 TMB quintile 6 -0.41 -1.35 0.56 1451.75 1.00 62 11 74 9 TRUE 0.40
colorectal cancer RAS_12 POLD1 Any mutation 239 103 TMB overall -0.41 -3.62 2.41 1496.10 1.00 411 223 87 16 TRUE 0.10
non-small cell lung cancer RAS_12 PREX2 Any mutation 120 14 TMB quintile 4 -0.15 -1.11 0.85 1528.37 1.00 230 115 9 5 FALSE 0.11
non-small cell lung cancer RAS_12 PREX2 Any mutation 206 84 TMB quintile 5 -0.35 -0.87 0.17 1601.59 1.00 360 184 62 22 FALSE 0.74
non-small cell lung cancer RAS_12 PREX2 Any mutation 326 98 TMB overall -0.23 -1.63 1.36 1490.55 1.00 590 299 71 27 FALSE 0.11
colorectal cancer RAS_12 AMER1 Any mutation 147 13 TMB quintile 3 0.19 -0.81 1.18 1397.33 1.00 332 142 8 5 FALSE 0.15
colorectal cancer RAS_12 AMER1 Any mutation 282 38 TMB quintile 4 0.84 0.21 1.48 1434.16 1.00 495 260 16 22 FALSE 1.95
colorectal cancer RAS_12 AMER1 Any mutation 233 62 TMB quintile 5 0.37 -0.13 0.91 1511.87 1.00 359 205 34 28 FALSE 0.80
colorectal cancer RAS_12 AMER1 Any mutation 20 55 TMB quintile 6 -0.22 -1.18 0.65 1446.02 1.00 84 14 49 6 FALSE 0.19
non-small cell lung cancer RAS_12 AMER1 Any mutation 231 18 TMB quintile 4 1.22 0.30 2.16 1468.15 1.00 524 220 7 11 FALSE 2.03
non-small cell lung cancer RAS_12 AMER1 Any mutation 399 107 TMB quintile 5 0.36 -0.06 0.75 1541.29 1.00 771 356 64 43 FALSE 1.07
colorectal cancer RAS_12 AMER1 Any mutation 682 168 TMB overall 0.31 -0.86 1.44 1483.07 1.00 1270 621 107 61 FALSE 0.23
non-small cell lung cancer RAS_12 AMER1 Any mutation 630 142 TMB overall 0.16 -3.15 3.21 1453.57 1.00 1305 576 88 54 FALSE 0.04
non-small cell lung cancer RAS_12 EPHA7 Any mutation 217 14 TMB quintile 4 -0.08 -1.15 0.86 1594.35 1.00 452 212 9 5 FALSE 0.06
non-small cell lung cancer RAS_12 EPHA7 Any mutation 364 101 TMB quintile 5 -0.30 -0.79 0.14 1532.50 1.00 672 337 74 27 FALSE 0.69
non-small cell lung cancer RAS_12 EPHA7 Any mutation 581 115 TMB overall -0.15 -1.81 1.75 1534.72 1.00 1124 549 83 32 FALSE 0.06
colorectal cancer KRAS_12 SPEN Any mutation 271 11 TMB quintile 4 -0.04 -1.29 1.06 1456.64 1.00 513 267 7 4 FALSE 0.03
colorectal cancer KRAS_12 SPEN Any mutation 229 31 TMB quintile 5 0.06 -0.68 0.84 1519.57 1.00 382 217 19 12 FALSE 0.06
colorectal cancer KRAS_12 SPEN Any mutation 18 107 TMB quintile 6 -0.45 -1.40 0.53 1537.10 1.00 63 9 98 9 FALSE 0.44
non-small cell lung cancer KRAS_12 SPEN Any mutation 230 15 TMB quintile 4 -1.11 -2.57 0.01 1486.62 1.00 519 228 13 2 FALSE 1.07
non-small cell lung cancer KRAS_12 SPEN Any mutation 396 87 TMB quintile 5 -0.87 -1.45 -0.32 1472.29 1.00 785 381 72 15 FALSE 2.54
uterine cancer KRAS_12 SPEN Any mutation 50 37 TMB quintile 5 0.71 -0.06 1.44 1697.85 1.00 188 39 26 11 FALSE 1.18
colorectal cancer KRAS_12 SPEN Any mutation 518 149 TMB overall -0.13 -2.22 1.93 1716.65 1.00 958 493 124 25 FALSE 0.04
non-small cell lung cancer KRAS_12 SPEN Any mutation 626 102 TMB overall -0.97 -2.56 0.78 1332.35 1.00 1304 609 85 17 FALSE 0.61
uterine cancer KRAS_12 SPEN Any mutation 55 114 TMB overall 1.18 -2.26 4.90 1432.12 1.00 217 39 98 16 FALSE 0.29
colorectal cancer KRAS_12 KMT2C Any mutation 264 12 TMB quintile 4 -0.26 -1.48 0.89 1427.65 1.00 501 260 8 4 FALSE 0.17
colorectal cancer KRAS_12 KMT2C Any mutation 212 61 TMB quintile 5 -0.78 -1.42 -0.17 1652.82 1.00 336 199 48 13 FALSE 1.76
colorectal cancer KRAS_12 KMT2C Any mutation 23 116 TMB quintile 6 -0.08 -0.94 0.79 982.26 1.00 63 9 102 14 FALSE 0.06
non-small cell lung cancer KRAS_12 KMT2C Any mutation 130 13 TMB quintile 3 -0.86 -2.43 0.25 1461.57 1.00 480 129 12 1 FALSE 0.71
non-small cell lung cancer KRAS_12 KMT2C Any mutation 230 36 TMB quintile 4 -0.11 -0.84 0.57 1439.69 1.00 506 219 25 11 FALSE 0.11
non-small cell lung cancer KRAS_12 KMT2C Any mutation 396 155 TMB quintile 5 -0.30 -0.68 0.07 1300.03 1.00 720 355 114 41 FALSE 0.92
uterine cancer KRAS_12 KMT2C Any mutation 48 42 TMB quintile 5 -0.51 -1.50 0.34 1527.83 1.00 165 42 36 6 FALSE 0.54
colorectal cancer KRAS_12 KMT2C Any mutation 499 189 TMB overall -0.39 -2.57 1.67 1492.50 1.00 900 468 158 31 FALSE 0.15
non-small cell lung cancer KRAS_12 KMT2C Any mutation 756 204 TMB overall -0.42 -1.59 0.63 1565.65 1.00 1706 703 151 53 FALSE 0.33
uterine cancer KRAS_12 KMT2C Any mutation 51 133 TMB overall -0.60 -3.42 2.43 1275.31 1.00 186 43 125 8 FALSE 0.17
cancer of unknown primary KRAS_12 TP53 Any mutation 23 39 TMB quintile 2 -0.07 -0.86 0.82 1448.09 1.00 64 14 30 9 TRUE 0.06
cancer of unknown primary KRAS_12 TP53 Any mutation 32 74 TMB quintile 3 -0.07 -0.73 0.63 1099.01 1.00 56 15 57 17 TRUE 0.08
cancer of unknown primary KRAS_12 TP53 Any mutation 34 87 TMB quintile 4 -0.66 -1.38 0.00 1230.29 1.00 41 19 72 15 TRUE 1.18
cancer of unknown primary KRAS_12 TP53 Any mutation 37 153 TMB quintile 5 -0.64 -1.27 0.03 1481.01 1.00 41 15 131 22 TRUE 1.23
colorectal cancer KRAS_12 TP53 Any mutation 17 104 TMB quintile 2 -1.43 -2.27 -0.60 1381.12 1.00 25 9 96 8 TRUE 3.07
colorectal cancer KRAS_12 TP53 Any mutation 145 411 TMB quintile 3 -1.26 -1.74 -0.81 1494.44 1.00 38 47 313 98 TRUE 7.02
colorectal cancer KRAS_12 TP53 Any mutation 280 655 TMB quintile 4 -1.18 -1.52 -0.83 1389.62 1.00 76 99 474 181 TRUE 10.57
colorectal cancer KRAS_12 TP53 Any mutation 247 423 TMB quintile 5 -0.60 -0.90 -0.28 1511.09 1.00 136 113 289 134 TRUE 3.76
colorectal cancer KRAS_12 TP53 Any mutation 20 78 TMB quintile 6 -1.06 -1.94 -0.17 1558.71 1.00 78 14 72 6 TRUE 1.70
non-small cell lung cancer KRAS_12 TP53 Any mutation 75 180 TMB quintile 2 -1.21 -1.80 -0.66 1523.89 1.00 204 59 164 16 TRUE 4.54
non-small cell lung cancer KRAS_12 TP53 Any mutation 130 324 TMB quintile 3 -1.40 -1.80 -0.97 1323.14 1.00 218 97 291 33 TRUE 10.49
non-small cell lung cancer KRAS_12 TP53 Any mutation 231 450 TMB quintile 4 -1.56 -1.87 -1.24 1604.00 1.00 178 160 379 71 TRUE 21.15
non-small cell lung cancer KRAS_12 TP53 Any mutation 410 996 TMB quintile 5 -1.70 -1.97 -1.44 1553.89 1.00 131 201 787 209 TRUE 36.18
pancreatic cancer KRAS_12 TP53 Any mutation 252 216 TMB quintile 2 1.75 1.35 2.23 1589.93 1.00 68 62 26 190 TRUE 14.18
pancreatic cancer KRAS_12 TP53 Any mutation 420 392 TMB quintile 3 1.79 1.44 2.16 1443.54 1.00 60 74 46 346 TRUE 36.18
pancreatic cancer KRAS_12 TP53 Any mutation 217 206 TMB quintile 4 1.48 0.95 1.91 1417.71 1.00 30 48 37 169 TRUE 8.64
pancreatic cancer KRAS_12 TP53 Any mutation 34 34 TMB quintile 5 1.47 0.84 2.05 1573.08 1.00 13 9 9 25 TRUE 6.06
uterine cancer KRAS_12 TP53 Any mutation 12 77 TMB quintile 2 -1.47 -2.45 -0.47 1527.94 1.00 60 9 74 3 TRUE 2.47
uterine cancer KRAS_12 TP53 Any mutation 25 167 TMB quintile 3 -1.30 -2.05 -0.60 1757.59 1.00 69 15 157 10 TRUE 3.40
uterine cancer KRAS_12 TP53 Any mutation 39 132 TMB quintile 4 -1.65 -2.40 -0.93 1343.80 1.00 81 31 124 8 TRUE 5.06
uterine cancer KRAS_12 TP53 Any mutation 50 68 TMB quintile 5 -1.26 -2.08 -0.49 1503.92 1.00 159 44 62 6 TRUE 2.74
cancer of unknown primary KRAS_12 TP53 Any mutation 129 378 TMB overall -0.41 -1.18 0.33 1415.21 1.00 204 64 313 65 TRUE 0.55
colorectal cancer KRAS_12 TP53 Any mutation 709 1671 TMB overall -1.09 -1.88 -0.32 1464.24 1.00 353 282 1244 427 TRUE 2.25
non-small cell lung cancer KRAS_12 TP53 Any mutation 846 1950 TMB overall -1.46 -2.27 -0.67 1493.14 1.00 731 517 1621 329 TRUE 3.60
pancreatic cancer KRAS_12 TP53 Any mutation 923 848 TMB overall 1.62 1.16 2.10 1600.17 1.00 171 193 118 730 TRUE 10.67
uterine cancer KRAS_12 TP53 Any mutation 128 483 TMB overall -1.48 -2.30 -0.68 1474.44 1.00 405 101 456 27 TRUE 3.65
colorectal cancer KRAS_12 ATRX Any mutation 271 19 TMB quintile 4 -0.29 -1.25 0.61 1560.87 1.00 507 265 13 6 TRUE 0.27
colorectal cancer KRAS_12 ATRX Any mutation 227 35 TMB quintile 5 -0.14 -0.87 0.57 1414.62 1.00 378 215 23 12 TRUE 0.16
colorectal cancer KRAS_12 ATRX Any mutation 18 59 TMB quintile 6 -1.11 -2.30 -0.02 1503.66 1.00 86 15 56 3 TRUE 1.21
non-small cell lung cancer KRAS_12 ATRX Any mutation 230 32 TMB quintile 4 -0.10 -0.83 0.59 1351.47 1.00 510 221 23 9 TRUE 0.11
non-small cell lung cancer KRAS_12 ATRX Any mutation 402 160 TMB quintile 5 0.24 -0.12 0.56 1499.52 1.00 746 343 101 59 TRUE 0.77
uterine cancer KRAS_12 ATRX Any mutation 12 11 TMB quintile 2 -2.50 -6.61 0.16 1519.36 1.00 122 12 11 0 TRUE 0.81
uterine cancer KRAS_12 ATRX Any mutation 24 14 TMB quintile 3 -2.66 -6.63 -0.10 1516.97 1.00 203 24 14 0 TRUE 0.97
uterine cancer KRAS_12 ATRX Any mutation 49 19 TMB quintile 5 -0.57 -2.08 0.66 1488.54 1.00 199 46 16 3 TRUE 0.38
colorectal cancer KRAS_12 ATRX Any mutation 516 113 TMB overall -0.52 -2.20 1.18 1541.24 1.00 971 495 92 21 TRUE 0.28
non-small cell lung cancer KRAS_12 ATRX Any mutation 632 192 TMB overall 0.08 -1.36 1.51 1617.23 1.00 1256 564 124 68 TRUE 0.04
uterine cancer KRAS_12 ATRX Any mutation 87 156 TMB overall -1.81 -4.27 0.32 1509.57 1.00 551 83 152 4 TRUE 0.94
colorectal cancer KRAS_12 ATR Any mutation 227 35 TMB quintile 5 -1.13 -2.08 -0.32 1300.43 1.00 371 221 29 6 FALSE 1.92
colorectal cancer KRAS_12 ATR Any mutation 20 65 TMB quintile 6 -0.78 -1.92 0.18 1502.24 1.00 91 15 60 5 FALSE 0.85
non-small cell lung cancer KRAS_12 ATR Any mutation 130 12 TMB quintile 3 -0.45 -1.70 0.58 1483.75 1.00 486 128 10 2 FALSE 0.36
non-small cell lung cancer KRAS_12 ATR Any mutation 230 15 TMB quintile 4 -0.55 -1.66 0.42 1489.26 1.00 522 227 12 3 FALSE 0.53
non-small cell lung cancer KRAS_12 ATR Any mutation 396 93 TMB quintile 5 -0.22 -0.69 0.22 1409.24 1.00 762 370 67 26 FALSE 0.45
colorectal cancer KRAS_12 ATR Any mutation 247 100 TMB overall -0.90 -2.96 1.31 1614.30 1.00 462 236 89 11 FALSE 0.38
non-small cell lung cancer KRAS_12 ATR Any mutation 756 120 TMB overall -0.38 -1.37 0.60 1364.97 1.00 1770 725 89 31 FALSE 0.33
non-small cell lung cancer KRAS_12 PDGFRA Any mutation 230 16 TMB quintile 4 -0.12 -1.16 0.86 1473.24 1.00 521 225 11 5 TRUE 0.09
non-small cell lung cancer KRAS_12 PDGFRA Any mutation 397 115 TMB quintile 5 -0.22 -0.63 0.17 1511.50 1.00 750 365 83 32 TRUE 0.51
non-small cell lung cancer KRAS_12 PDGFRA Any mutation 627 131 TMB overall -0.16 -2.01 1.78 1354.99 1.00 1271 590 94 37 TRUE 0.07
colorectal cancer KRAS_12 FBXW7 Any mutation 144 22 TMB quintile 3 -0.63 -1.55 0.25 1513.56 1.00 326 140 18 4 TRUE 0.74
colorectal cancer KRAS_12 FBXW7 Any mutation 274 85 TMB quintile 4 -0.15 -0.65 0.29 1377.06 1.00 470 247 58 27 TRUE 0.28
colorectal cancer KRAS_12 FBXW7 Any mutation 243 160 TMB quintile 5 0.35 -0.02 0.69 1412.16 1.00 317 173 90 70 TRUE 1.29
colorectal cancer KRAS_12 FBXW7 Any mutation 18 65 TMB quintile 6 -0.28 -1.20 0.56 1543.18 1.00 73 11 58 7 TRUE 0.26
uterine cancer KRAS_12 FBXW7 Any mutation 24 30 TMB quintile 3 -0.80 -2.38 0.44 1620.51 1.00 189 23 29 1 TRUE 0.57
uterine cancer KRAS_12 FBXW7 Any mutation 39 29 TMB quintile 4 -0.02 -1.09 0.89 1609.87 1.00 166 34 24 5 TRUE 0.01
uterine cancer KRAS_12 FBXW7 Any mutation 49 30 TMB quintile 5 0.60 -0.26 1.38 1426.88 1.00 192 40 21 9 TRUE 0.83
colorectal cancer KRAS_12 FBXW7 Any mutation 679 332 TMB overall -0.19 -1.18 0.79 1470.05 1.00 1186 571 224 108 TRUE 0.15
uterine cancer KRAS_12 FBXW7 Any mutation 116 136 TMB overall 0.11 -1.23 1.51 1267.62 1.00 576 97 117 19 TRUE 0.06
uterine cancer KRAS_12 NSD1 Any mutation 52 46 TMB quintile 5 0.17 -0.64 0.96 1665.57 1.00 185 42 36 10 FALSE 0.18
uterine cancer KRAS_12 NSD1 Any mutation 56 115 TMB overall 0.68 -2.53 4.44 1443.47 1.00 209 42 101 14 FALSE 0.16
colorectal cancer KRAS_12 FLT4 Any mutation 271 20 TMB quintile 4 -0.52 -1.65 0.42 1512.14 1.00 505 266 15 5 TRUE 0.50
colorectal cancer KRAS_12 FLT4 Any mutation 228 40 TMB quintile 5 -0.43 -1.15 0.25 1436.86 1.00 373 217 29 11 TRUE 0.65
colorectal cancer KRAS_12 FLT4 Any mutation 21 72 TMB quintile 6 0.38 -0.45 1.22 1501.96 1.00 74 9 60 12 TRUE 0.41
non-small cell lung cancer KRAS_12 FLT4 Any mutation 230 14 TMB quintile 4 0.51 -0.57 1.58 1490.65 1.00 525 223 7 7 TRUE 0.47
non-small cell lung cancer KRAS_12 FLT4 Any mutation 397 74 TMB quintile 5 -0.22 -0.75 0.27 1491.07 1.00 776 377 54 20 TRUE 0.40
colorectal cancer KRAS_12 FLT4 Any mutation 520 132 TMB overall -0.17 -1.83 1.71 1528.81 1.00 952 492 104 28 TRUE 0.07
non-small cell lung cancer KRAS_12 FLT4 Any mutation 627 88 TMB overall 0.12 -1.71 2.09 1339.44 1.00 1301 600 61 27 TRUE 0.05
colorectal cancer KRAS_12 PTPRD Any mutation 227 29 TMB quintile 5 -0.68 -1.56 0.16 1354.05 1.00 379 220 22 7 FALSE 0.93
colorectal cancer KRAS_12 PTPRD Any mutation 18 61 TMB quintile 6 -0.63 -1.76 0.41 1456.50 1.00 86 13 56 5 FALSE 0.60
non-small cell lung cancer KRAS_12 PTPRD Any mutation 130 16 TMB quintile 3 -0.33 -1.66 0.82 1473.50 1.00 484 127 13 3 FALSE 0.22
non-small cell lung cancer KRAS_12 PTPRD Any mutation 231 53 TMB quintile 4 0.39 -0.20 0.96 1491.09 1.00 500 210 32 21 FALSE 0.72
non-small cell lung cancer KRAS_12 PTPRD Any mutation 408 298 TMB quintile 5 -0.15 -0.42 0.12 1422.13 1.00 656 320 210 88 FALSE 0.53
colorectal cancer KRAS_12 PTPRD Any mutation 245 90 TMB overall -0.64 -2.95 1.72 1531.73 1.00 465 233 78 12 FALSE 0.23
non-small cell lung cancer KRAS_12 PTPRD Any mutation 769 384 TMB overall -0.30 -2.35 1.63 1522.47 1.00 1647 657 272 112 FALSE 0.12
non-small cell lung cancer KRAS_12 PIK3C2G Any mutation 230 12 TMB quintile 4 -0.47 -1.74 0.72 1398.68 1.00 520 227 9 3 FALSE 0.36
non-small cell lung cancer KRAS_12 PIK3C2G Any mutation 395 103 TMB quintile 5 -0.50 -0.98 -0.05 1586.81 1.00 751 371 79 24 FALSE 1.41
non-small cell lung cancer KRAS_12 PIK3C2G Any mutation 625 115 TMB overall -0.45 -2.34 1.75 1439.69 1.00 1271 598 88 27 FALSE 0.19
colorectal cancer KRAS_12 CREBBP Any mutation 271 17 TMB quintile 4 -0.98 -2.31 0.16 1502.42 1.00 506 268 14 3 TRUE 0.98
colorectal cancer KRAS_12 CREBBP Any mutation 230 49 TMB quintile 5 -0.22 -0.82 0.41 1426.92 1.00 370 214 33 16 TRUE 0.32
colorectal cancer KRAS_12 CREBBP Any mutation 22 116 TMB quintile 6 -0.49 -1.38 0.38 1254.05 1.00 54 10 104 12 TRUE 0.58
non-small cell lung cancer KRAS_12 CREBBP Any mutation 130 11 TMB quintile 3 0.02 -1.14 1.17 1466.08 1.00 488 127 8 3 TRUE 0.01
non-small cell lung cancer KRAS_12 CREBBP Any mutation 230 12 TMB quintile 4 -0.07 -1.11 0.94 1583.93 1.00 524 226 8 4 TRUE 0.05
non-small cell lung cancer KRAS_12 CREBBP Any mutation 395 106 TMB quintile 5 -0.32 -0.78 0.13 1407.43 1.00 758 368 79 27 TRUE 0.77
colorectal cancer KRAS_12 CREBBP Any mutation 523 182 TMB overall -0.56 -2.61 1.51 1469.83 1.00 930 492 151 31 TRUE 0.25
non-small cell lung cancer KRAS_12 CREBBP Any mutation 755 129 TMB overall -0.12 -1.34 1.10 1445.64 1.00 1770 721 95 34 TRUE 0.08
colorectal cancer KRAS_12 AXIN2 Any mutation 271 20 TMB quintile 4 0.48 -0.45 1.41 1492.35 1.00 510 261 10 10 TRUE 0.51
colorectal cancer KRAS_12 AXIN2 Any mutation 227 27 TMB quintile 5 -0.75 -1.74 0.10 1609.34 1.00 379 221 21 6 TRUE 0.98
colorectal cancer KRAS_12 AXIN2 Any mutation 18 63 TMB quintile 6 -0.88 -1.98 0.10 1453.68 1.00 81 14 59 4 TRUE 0.97
colorectal cancer KRAS_12 AXIN2 Any mutation 516 110 TMB overall -0.40 -2.21 1.37 1507.25 1.00 970 496 90 20 TRUE 0.18
non-small cell lung cancer KRAS_12 DOT1L Any mutation 230 24 TMB quintile 4 -0.31 -1.05 0.38 1522.29 1.00 516 224 18 6 FALSE 0.39
non-small cell lung cancer KRAS_12 DOT1L Any mutation 396 75 TMB quintile 5 -0.16 -0.65 0.32 1550.79 1.00 775 374 53 22 FALSE 0.28
non-small cell lung cancer KRAS_12 DOT1L Any mutation 626 99 TMB overall -0.24 -1.26 0.70 1510.15 1.00 1291 598 71 28 FALSE 0.20
colorectal cancer KRAS_12 PTPRS Any mutation 140 17 TMB quintile 3 -0.40 -1.52 0.65 1158.39 1.00 329 136 13 4 FALSE 0.32
colorectal cancer KRAS_12 PTPRS Any mutation 264 34 TMB quintile 4 0.12 -0.55 0.76 1455.89 1.00 488 251 21 13 FALSE 0.13
colorectal cancer KRAS_12 PTPRS Any mutation 215 74 TMB quintile 5 -0.17 -0.70 0.33 1504.40 1.00 335 191 50 24 FALSE 0.29
colorectal cancer KRAS_12 PTPRS Any mutation 23 128 TMB quintile 6 -0.14 -1.02 0.80 1539.97 1.00 42 7 112 16 FALSE 0.12
colorectal cancer KRAS_12 PTPRS Any mutation 642 253 TMB overall -0.12 -1.54 1.29 1445.38 1.00 1194 585 196 57 FALSE 0.06
colorectal cancer KRAS_12 SMARCA4 Any mutation 271 16 TMB quintile 4 -0.57 -1.74 0.44 1374.94 1.00 508 267 12 4 FALSE 0.50
colorectal cancer KRAS_12 SMARCA4 Any mutation 228 47 TMB quintile 5 -0.24 -0.88 0.37 1504.92 1.00 370 213 32 15 FALSE 0.34
colorectal cancer KRAS_12 SMARCA4 Any mutation 22 100 TMB quintile 6 -0.18 -1.08 0.69 1379.86 1.00 65 10 88 12 FALSE 0.16
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 131 35 TMB quintile 3 0.81 0.15 1.51 1471.32 1.00 479 116 20 15 FALSE 1.67
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 231 67 TMB quintile 4 0.15 -0.34 0.66 1577.00 1.00 490 209 45 22 FALSE 0.26
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 399 194 TMB quintile 5 -0.11 -0.43 0.19 1371.69 1.00 698 342 137 57 FALSE 0.30
uterine cancer KRAS_12 SMARCA4 Any mutation 51 39 TMB quintile 5 -0.17 -1.12 0.69 1364.35 1.00 189 44 32 7 FALSE 0.15
colorectal cancer KRAS_12 SMARCA4 Any mutation 521 163 TMB overall -0.29 -2.19 1.62 1458.43 1.00 943 490 132 31 FALSE 0.12
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 761 296 TMB overall 0.30 -0.62 1.26 1496.06 1.00 1667 667 202 94 FALSE 0.28
uterine cancer KRAS_12 SMARCA4 Any mutation 53 91 TMB overall -0.47 -3.26 2.61 1528.65 1.00 219 45 83 8 FALSE 0.13
colorectal cancer KRAS_12 PTPRT Any mutation 144 18 TMB quintile 3 0.35 -0.53 1.24 1474.43 1.00 333 136 10 8 FALSE 0.35
colorectal cancer KRAS_12 PTPRT Any mutation 271 39 TMB quintile 4 -1.20 -2.17 -0.39 1458.66 1.00 486 266 34 5 FALSE 2.17
colorectal cancer KRAS_12 PTPRT Any mutation 229 59 TMB quintile 5 -0.57 -1.18 0.02 1555.37 1.00 356 214 44 15 FALSE 1.18
colorectal cancer KRAS_12 PTPRT Any mutation 19 66 TMB quintile 6 -0.10 -1.06 0.77 1457.15 1.00 82 11 58 8 FALSE 0.08
non-small cell lung cancer KRAS_12 PTPRT Any mutation 130 17 TMB quintile 3 -0.02 -1.23 1.01 1454.06 1.00 483 126 13 4 FALSE 0.01
non-small cell lung cancer KRAS_12 PTPRT Any mutation 230 38 TMB quintile 4 -0.12 -0.84 0.56 1499.41 1.00 506 219 27 11 FALSE 0.13
non-small cell lung cancer KRAS_12 PTPRT Any mutation 404 272 TMB quintile 5 -0.39 -0.69 -0.10 1483.13 1.00 668 335 203 69 FALSE 2.02
colorectal cancer KRAS_12 PTPRT Any mutation 663 182 TMB overall -0.38 -1.55 0.83 1689.89 1.00 1257 627 146 36 FALSE 0.28
non-small cell lung cancer KRAS_12 PTPRT Any mutation 764 348 TMB overall -0.52 -2.56 1.59 1514.31 1.00 1662 680 264 84 FALSE 0.21
non-small cell lung cancer KRAS_12 HGF Any mutation 230 27 TMB quintile 4 -0.31 -1.25 0.52 1464.92 1.00 513 223 20 7 FALSE 0.31
non-small cell lung cancer KRAS_12 HGF Any mutation 397 138 TMB quintile 5 -0.22 -0.60 0.17 1645.70 1.00 734 358 99 39 FALSE 0.57
non-small cell lung cancer KRAS_12 HGF Any mutation 627 180 TMB overall -0.65 -3.56 1.89 1704.76 1.00 1254 581 134 46 FALSE 0.20
colorectal cancer KRAS_12 PIK3CA Any mutation 146 51 TMB quintile 3 0.81 0.24 1.39 1570.74 1.00 318 121 26 25 TRUE 2.31
colorectal cancer KRAS_12 PIK3CA Any mutation 273 146 TMB quintile 4 0.54 0.17 0.88 1438.83 1.00 444 207 80 66 TRUE 2.51
colorectal cancer KRAS_12 PIK3CA Any mutation 234 209 TMB quintile 5 0.06 -0.29 0.39 1584.30 1.00 282 157 132 77 TRUE 0.14
colorectal cancer KRAS_12 PIK3CA Any mutation 21 95 TMB quintile 6 -0.13 -0.99 0.68 1367.60 1.00 62 10 84 11 TRUE 0.12
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 75 18 TMB quintile 2 -0.68 -1.69 0.13 1527.70 1.00 349 74 17 1 TRUE 0.86
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 130 34 TMB quintile 3 -0.49 -1.25 0.20 1570.08 1.00 467 125 29 5 TRUE 0.75
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 231 56 TMB quintile 4 -0.53 -1.15 0.04 1634.10 1.00 487 220 45 11 TRUE 1.15
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 396 123 TMB quintile 5 -0.16 -0.57 0.23 1439.45 1.00 750 359 86 37 TRUE 0.36
uterine cancer KRAS_12 PIK3CA Any mutation 12 33 TMB quintile 2 -0.23 -1.46 0.86 1561.07 1.00 103 10 31 2 TRUE 0.16
uterine cancer KRAS_12 PIK3CA Any mutation 24 103 TMB quintile 3 0.07 -0.73 0.86 1516.67 1.00 134 14 93 10 TRUE 0.07
uterine cancer KRAS_12 PIK3CA Any mutation 43 121 TMB quintile 4 0.64 0.03 1.33 1294.59 1.00 109 16 94 27 TRUE 1.32
uterine cancer KRAS_12 PIK3CA Any mutation 63 196 TMB quintile 5 0.47 -0.05 1.06 1394.57 1.00 102 19 152 44 TRUE 1.00
colorectal cancer KRAS_12 PIK3CA Any mutation 674 501 TMB overall 0.34 -0.69 1.38 1530.05 1.00 1106 495 322 179 TRUE 0.29
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 832 231 TMB overall -0.47 -1.11 0.11 1545.60 1.00 2053 778 177 54 TRUE 0.87
uterine cancer KRAS_12 PIK3CA Any mutation 146 548 TMB overall 0.17 -0.78 1.12 1440.93 1.00 463 59 461 87 TRUE 0.14
colorectal cancer KRAS_12 ALK Any mutation 271 20 TMB quintile 4 -0.90 -1.98 0.09 1383.22 1.00 504 267 16 4 TRUE 1.04
colorectal cancer KRAS_12 ALK Any mutation 227 42 TMB quintile 5 -0.83 -1.61 -0.14 1518.12 1.00 368 218 33 9 TRUE 1.55
colorectal cancer KRAS_12 ALK Any mutation 18 45 TMB quintile 6 -0.91 -2.10 0.21 1457.58 1.00 95 15 42 3 TRUE 0.86
non-small cell lung cancer KRAS_12 ALK Any mutation 130 13 TMB quintile 3 -0.56 -2.09 0.76 1339.75 1.00 486 128 11 2 TRUE 0.36
non-small cell lung cancer KRAS_12 ALK Any mutation 230 22 TMB quintile 4 0.19 -0.69 1.05 1568.39 1.00 519 222 14 8 TRUE 0.17
non-small cell lung cancer KRAS_12 ALK Any mutation 395 118 TMB quintile 5 -0.05 -0.46 0.35 1446.00 1.00 753 358 81 37 TRUE 0.10
colorectal cancer KRAS_12 ALK Any mutation 516 107 TMB overall -0.89 -2.48 0.54 1400.16 1.00 967 500 91 16 TRUE 0.65
non-small cell lung cancer KRAS_12 ALK Any mutation 755 164 TMB overall -0.35 -2.16 1.44 1551.80 1.00 1767 708 117 47 TRUE 0.15
colorectal cancer KRAS_12 RNF43 Any mutation 144 12 TMB quintile 3 -0.95 -2.54 0.27 1410.54 1.00 333 142 10 2 TRUE 0.74
colorectal cancer KRAS_12 RNF43 Any mutation 271 30 TMB quintile 4 -0.45 -1.31 0.30 1443.36 1.00 499 263 22 8 TRUE 0.57
colorectal cancer KRAS_12 RNF43 Any mutation 232 76 TMB quintile 5 -0.87 -1.50 -0.29 1483.07 1.00 348 216 60 16 TRUE 2.38
colorectal cancer KRAS_12 RNF43 Any mutation 21 146 TMB quintile 6 -0.68 -1.59 0.21 1499.70 1.00 41 8 133 13 TRUE 0.86
colorectal cancer KRAS_12 RNF43 Any mutation 668 264 TMB overall -0.72 -2.33 0.87 1493.27 1.00 1221 629 225 39 TRUE 0.43
colorectal cancer KRAS_12 PTEN Any mutation 271 29 TMB quintile 4 0.00 -0.78 0.75 1391.80 1.00 503 260 18 11 TRUE 0.00
colorectal cancer KRAS_12 PTEN Any mutation 227 69 TMB quintile 5 -0.85 -1.46 -0.27 1497.69 1.00 360 213 55 14 TRUE 2.28
colorectal cancer KRAS_12 PTEN Any mutation 20 80 TMB quintile 6 -0.82 -1.81 0.07 1630.94 1.00 76 14 74 6 TRUE 1.05
non-small cell lung cancer KRAS_12 PTEN Any mutation 130 17 TMB quintile 3 -1.45 -2.80 -0.39 1441.05 1.00 480 129 16 1 TRUE 1.81
non-small cell lung cancer KRAS_12 PTEN Any mutation 230 27 TMB quintile 4 -1.72 -3.12 -0.76 1568.70 1.00 507 229 26 1 TRUE 2.43
non-small cell lung cancer KRAS_12 PTEN Any mutation 395 75 TMB quintile 5 -1.00 -1.64 -0.37 1507.90 1.00 772 382 62 13 TRUE 2.75
uterine cancer KRAS_12 PTEN Any mutation 12 16 TMB quintile 2 -0.22 -2.04 1.26 1582.49 1.00 119 11 15 1 TRUE 0.10
uterine cancer KRAS_12 PTEN Any mutation 26 63 TMB quintile 3 0.51 -0.30 1.34 1596.72 1.00 178 17 54 9 TRUE 0.63
uterine cancer KRAS_12 PTEN Any mutation 48 120 TMB quintile 4 0.49 -0.14 1.09 1218.58 1.00 126 22 94 26 TRUE 0.89
uterine cancer KRAS_12 PTEN Any mutation 79 315 TMB quintile 5 0.70 -0.01 1.45 1669.53 1.00 60 9 245 70 TRUE 1.24
uterine cancer KRAS_12 PTEN Any mutation 6 103 TMB quintile 6 0.45 -1.15 2.26 1536.69 1.00 13 0 97 6 TRUE 0.22
colorectal cancer KRAS_12 PTEN Any mutation 518 178 TMB overall -0.58 -2.23 0.97 1435.43 1.00 939 487 147 31 TRUE 0.33
non-small cell lung cancer KRAS_12 PTEN Any mutation 755 119 TMB overall -1.37 -2.39 -0.49 1551.81 1.00 1759 740 104 15 TRUE 2.26
uterine cancer KRAS_12 PTEN Any mutation 171 617 TMB overall 0.42 -0.78 1.63 1596.86 1.00 496 59 505 112 TRUE 0.29
colorectal cancer KRAS_12 BCOR Any mutation 271 11 TMB quintile 4 0.56 -0.59 1.64 1374.66 1.00 515 265 5 6 FALSE 0.45
colorectal cancer KRAS_12 BCOR Any mutation 227 39 TMB quintile 5 0.06 -0.61 0.69 1398.70 1.00 378 212 24 15 FALSE 0.07
colorectal cancer KRAS_12 BCOR Any mutation 18 57 TMB quintile 6 -2.11 -4.20 -0.65 1491.53 1.00 82 17 56 1 FALSE 1.66
non-small cell lung cancer KRAS_12 BCOR Any mutation 230 22 TMB quintile 4 0.05 -0.71 0.79 1185.68 1.00 518 223 15 7 FALSE 0.04
non-small cell lung cancer KRAS_12 BCOR Any mutation 400 92 TMB quintile 5 0.27 -0.14 0.73 571.14 1.00 774 365 57 35 FALSE 0.67
uterine cancer KRAS_12 BCOR Any mutation 39 19 TMB quintile 4 0.11 -1.07 1.14 1571.42 1.00 175 35 15 4 FALSE 0.07
uterine cancer KRAS_12 BCOR Any mutation 51 69 TMB quintile 5 0.32 -0.31 0.94 1404.91 1.00 164 35 53 16 FALSE 0.48
colorectal cancer KRAS_12 BCOR Any mutation 516 107 TMB overall -0.46 -2.71 1.64 1418.14 1.00 975 494 85 22 FALSE 0.17
non-small cell lung cancer KRAS_12 BCOR Any mutation 630 114 TMB overall 0.16 -1.09 1.41 1427.36 1.00 1292 588 72 42 FALSE 0.09
uterine cancer KRAS_12 BCOR Any mutation 92 134 TMB overall 0.02 -1.70 1.87 1218.46 1.00 374 71 113 21 FALSE 0.01
colorectal cancer KRAS_12 CTNNB1 Any mutation 144 38 TMB quintile 3 0.62 0.01 1.25 1362.95 1.00 324 127 21 17 TRUE 1.29
colorectal cancer KRAS_12 CTNNB1 Any mutation 272 35 TMB quintile 4 0.69 0.09 1.31 1572.06 1.00 504 253 16 19 TRUE 1.53
colorectal cancer KRAS_12 CTNNB1 Any mutation 229 48 TMB quintile 5 0.00 -0.57 0.56 1491.62 1.00 368 212 31 17 TRUE 0.00
colorectal cancer KRAS_12 CTNNB1 Any mutation 19 35 TMB quintile 6 -0.04 -1.09 0.85 1429.96 1.00 93 15 31 4 TRUE 0.03
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 75 12 TMB quintile 2 -0.83 -1.90 0.06 1604.77 1.00 355 74 11 1 TRUE 1.04
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 130 22 TMB quintile 3 -1.09 -2.27 -0.23 1437.66 1.00 474 130 22 0 TRUE 1.49
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 232 33 TMB quintile 4 -0.58 -1.29 0.12 1379.77 1.00 508 224 25 8 TRUE 0.98
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 395 47 TMB quintile 5 -0.70 -1.32 -0.10 1604.31 1.00 791 385 37 10 TRUE 1.58
uterine cancer KRAS_12 CTNNB1 Any mutation 24 28 TMB quintile 3 -2.16 -4.09 -0.75 1433.95 1.00 189 24 28 0 TRUE 1.84
uterine cancer KRAS_12 CTNNB1 Any mutation 39 33 TMB quintile 4 -1.47 -2.70 -0.30 1351.22 1.00 160 36 30 3 TRUE 1.80
uterine cancer KRAS_12 CTNNB1 Any mutation 49 61 TMB quintile 5 -2.04 -3.29 -1.01 1419.36 1.00 157 47 59 2 TRUE 3.19
colorectal cancer KRAS_12 CTNNB1 Any mutation 664 156 TMB overall 0.32 -0.61 1.31 1555.59 1.00 1289 607 99 57 TRUE 0.31
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 832 114 TMB overall -0.80 -1.53 -0.10 1316.70 1.00 2128 813 95 19 TRUE 1.51
uterine cancer KRAS_12 CTNNB1 Any mutation 114 137 TMB overall -1.91 -3.32 -0.74 1379.03 1.00 552 109 132 5 TRUE 2.49
cancer of unknown primary KRAS_12 ARID1A Any mutation 33 15 TMB quintile 4 -0.28 -1.53 0.81 1511.55 1.00 97 30 12 3 TRUE 0.20
cancer of unknown primary KRAS_12 ARID1A Any mutation 36 62 TMB quintile 5 -0.44 -1.28 0.32 1509.98 1.00 113 28 54 8 TRUE 0.54
cancer of unknown primary KRAS_12 ARID1A Any mutation 6 16 TMB quintile 6 0.68 -0.62 2.33 1556.19 1.00 9 1 11 5 TRUE 0.41
colorectal cancer KRAS_12 ARID1A Any mutation 272 32 TMB quintile 4 0.42 -0.32 1.09 1428.33 1.00 503 257 17 15 TRUE 0.61
colorectal cancer KRAS_12 ARID1A Any mutation 232 116 TMB quintile 5 -0.76 -1.22 -0.32 1439.90 1.00 332 206 90 26 TRUE 2.97
colorectal cancer KRAS_12 ARID1A Any mutation 24 155 TMB quintile 6 -0.60 -1.46 0.23 1256.40 1.00 44 9 140 15 TRUE 0.77
non-small cell lung cancer KRAS_12 ARID1A Any mutation 130 12 TMB quintile 3 -0.15 -1.28 1.00 1382.16 1.00 487 127 9 3 TRUE 0.10
non-small cell lung cancer KRAS_12 ARID1A Any mutation 230 56 TMB quintile 4 -0.47 -1.11 0.10 1561.57 1.00 491 218 44 12 TRUE 0.87
non-small cell lung cancer KRAS_12 ARID1A Any mutation 404 187 TMB quintile 5 -0.28 -0.61 0.06 1581.29 1.00 703 353 136 51 TRUE 1.02
pancreatic cancer KRAS_12 ARID1A Any mutation 252 13 TMB quintile 2 -0.93 -1.87 -0.07 1561.65 1.00 87 246 7 6 TRUE 1.42
pancreatic cancer KRAS_12 ARID1A Any mutation 419 44 TMB quintile 3 0.05 -0.60 0.79 1457.71 1.00 98 382 7 37 TRUE 0.06
pancreatic cancer KRAS_12 ARID1A Any mutation 219 45 TMB quintile 4 -0.16 -0.83 0.52 1462.40 1.00 54 186 12 33 TRUE 0.20
pancreatic cancer KRAS_12 ARID1A Any mutation 35 17 TMB quintile 5 0.00 -0.96 0.92 1457.23 1.00 16 25 7 10 TRUE 0.00
uterine cancer KRAS_12 ARID1A Any mutation 24 28 TMB quintile 3 0.41 -0.78 1.47 1506.07 1.00 194 20 24 4 TRUE 0.33
uterine cancer KRAS_12 ARID1A Any mutation 43 77 TMB quintile 4 1.31 0.65 1.96 1380.47 1.00 143 18 52 25 TRUE 4.07
uterine cancer KRAS_12 ARID1A Any mutation 71 307 TMB quintile 5 0.95 0.19 1.78 1519.98 1.00 64 7 243 64 TRUE 1.73
cancer of unknown primary KRAS_12 ARID1A Any mutation 75 93 TMB overall -0.03 -1.57 1.36 1381.42 1.00 219 59 77 16 TRUE 0.02
colorectal cancer KRAS_12 ARID1A Any mutation 528 303 TMB overall -0.30 -2.31 1.67 1436.90 1.00 879 472 247 56 TRUE 0.12
non-small cell lung cancer KRAS_12 ARID1A Any mutation 764 255 TMB overall -0.32 -1.43 0.89 1461.90 1.00 1681 698 189 66 TRUE 0.24
pancreatic cancer KRAS_12 ARID1A Any mutation 925 119 TMB overall -0.27 -1.18 0.64 1574.42 1.00 255 839 33 86 TRUE 0.26
uterine cancer KRAS_12 ARID1A Any mutation 141 520 TMB overall 0.72 -1.03 2.38 1451.86 1.00 410 45 424 96 TRUE 0.38
colorectal cancer KRAS_12 PIK3R1 Any mutation 271 22 TMB quintile 4 0.01 -0.91 0.86 1379.88 1.00 507 263 14 8 TRUE 0.01
colorectal cancer KRAS_12 PIK3R1 Any mutation 228 29 TMB quintile 5 0.43 -0.29 1.16 1340.33 1.00 386 214 15 14 TRUE 0.60
colorectal cancer KRAS_12 PIK3R1 Any mutation 20 56 TMB quintile 6 -0.29 -1.24 0.59 1693.26 1.00 86 14 50 6 TRUE 0.26
uterine cancer KRAS_12 PIK3R1 Any mutation 24 40 TMB quintile 3 -0.86 -2.07 0.16 1544.18 1.00 183 22 38 2 TRUE 0.90
uterine cancer KRAS_12 PIK3R1 Any mutation 41 68 TMB quintile 4 -0.48 -1.21 0.22 1605.77 1.00 141 32 59 9 TRUE 0.72
uterine cancer KRAS_12 PIK3R1 Any mutation 54 117 TMB quintile 5 -0.48 -1.07 0.10 1493.86 1.00 137 37 100 17 TRUE 0.95
colorectal cancer KRAS_12 PIK3R1 Any mutation 519 107 TMB overall 0.06 -1.68 1.72 1473.64 1.00 979 491 79 28 TRUE 0.03
uterine cancer KRAS_12 PIK3R1 Any mutation 121 262 TMB overall -0.78 -1.89 0.12 1506.42 1.00 494 93 234 28 TRUE 0.91
colorectal cancer KRAS_12 FAT1 Any mutation 271 17 TMB quintile 4 -0.13 -1.17 0.87 1264.28 1.00 510 265 11 6 FALSE 0.10
colorectal cancer KRAS_12 FAT1 Any mutation 229 64 TMB quintile 5 -0.77 -1.40 -0.18 1545.50 1.00 356 215 50 14 FALSE 1.95
colorectal cancer KRAS_12 FAT1 Any mutation 23 145 TMB quintile 6 -0.68 -1.49 0.24 1391.53 1.00 53 10 132 13 FALSE 0.92
non-small cell lung cancer KRAS_12 FAT1 Any mutation 130 16 TMB quintile 3 0.03 -1.11 1.06 1460.13 1.00 484 126 12 4 FALSE 0.02
non-small cell lung cancer KRAS_12 FAT1 Any mutation 230 43 TMB quintile 4 -0.28 -1.00 0.40 1515.35 1.00 505 219 32 11 FALSE 0.36
non-small cell lung cancer KRAS_12 FAT1 Any mutation 400 227 TMB quintile 5 -0.25 -0.57 0.08 1512.29 1.00 682 337 164 63 FALSE 0.88
uterine cancer KRAS_12 FAT1 Any mutation 50 49 TMB quintile 5 0.17 -0.64 0.90 1628.97 1.00 185 40 39 10 FALSE 0.17
colorectal cancer KRAS_12 FAT1 Any mutation 523 226 TMB overall -0.49 -2.62 1.60 1455.30 1.00 919 490 193 33 FALSE 0.20
non-small cell lung cancer KRAS_12 FAT1 Any mutation 760 300 TMB overall -0.42 -2.31 1.44 1540.66 1.00 1678 682 222 78 FALSE 0.18
uterine cancer KRAS_12 FAT1 Any mutation 54 164 TMB overall 0.45 -2.90 4.12 1351.00 1.00 202 40 150 14 FALSE 0.10
colorectal cancer KRAS_12 CIC Any mutation 271 17 TMB quintile 4 -0.06 -1.00 0.88 1451.63 1.00 510 265 11 6 TRUE 0.05
colorectal cancer KRAS_12 CIC Any mutation 229 40 TMB quintile 5 -0.20 -0.86 0.44 1508.54 1.00 375 216 27 13 TRUE 0.25
colorectal cancer KRAS_12 CIC Any mutation 20 79 TMB quintile 6 0.07 -0.83 0.94 1490.88 1.00 76 10 69 10 TRUE 0.06
colorectal cancer KRAS_12 CIC Any mutation 520 136 TMB overall -0.06 -1.86 1.72 1374.98 1.00 961 491 107 29 TRUE 0.03
colorectal cancer KRAS_12 NCOR1 Any mutation 271 16 TMB quintile 4 -0.56 -1.72 0.48 1346.86 1.00 508 267 12 4 FALSE 0.51
colorectal cancer KRAS_12 NCOR1 Any mutation 228 32 TMB quintile 5 -0.77 -1.64 0.04 1502.24 1.00 379 221 25 7 FALSE 1.13
colorectal cancer KRAS_12 NCOR1 Any mutation 20 81 TMB quintile 6 0.14 -0.75 1.00 1570.02 1.00 72 9 70 11 FALSE 0.12
non-small cell lung cancer KRAS_12 NCOR1 Any mutation 230 21 TMB quintile 4 -0.55 -1.46 0.18 1418.77 1.00 516 226 17 4 FALSE 0.73
non-small cell lung cancer KRAS_12 NCOR1 Any mutation 398 71 TMB quintile 5 -0.31 -0.83 0.18 1404.97 1.00 782 379 52 19 FALSE 0.62
colorectal cancer KRAS_12 NCOR1 Any mutation 519 129 TMB overall -0.37 -2.23 1.59 1551.55 1.00 959 497 107 22 FALSE 0.16
non-small cell lung cancer KRAS_12 NCOR1 Any mutation 628 92 TMB overall -0.45 -1.65 0.57 1557.04 1.00 1298 605 69 23 FALSE 0.35
colorectal cancer KRAS_12 POLE Any mutation 227 38 TMB quintile 5 -0.52 -1.26 0.15 1497.80 1.00 373 217 28 10 TRUE 0.82
colorectal cancer KRAS_12 POLE Any mutation 19 93 TMB quintile 6 -0.16 -1.07 0.75 1421.68 1.00 66 9 83 10 TRUE 0.14
non-small cell lung cancer KRAS_12 POLE Any mutation 230 20 TMB quintile 4 -0.03 -0.96 0.82 1327.37 1.00 518 224 14 6 TRUE 0.02
non-small cell lung cancer KRAS_12 POLE Any mutation 397 102 TMB quintile 5 0.33 -0.09 0.74 1389.32 1.00 771 357 62 40 TRUE 0.90
uterine cancer KRAS_12 POLE Any mutation 49 24 TMB quintile 5 0.37 -0.64 1.33 1518.09 1.00 197 43 18 6 TRUE 0.34
colorectal cancer KRAS_12 POLE Any mutation 246 131 TMB overall -0.31 -2.84 2.37 1393.68 1.00 439 226 111 20 TRUE 0.09
non-small cell lung cancer KRAS_12 POLE Any mutation 627 122 TMB overall 0.14 -1.24 1.37 1372.55 1.00 1289 581 76 46 TRUE 0.08
uterine cancer KRAS_12 POLE Any mutation 52 104 TMB overall 0.67 -2.83 4.58 1504.39 1.00 220 43 95 9 TRUE 0.14
non-small cell lung cancer KRAS_12 NOTCH2 Any mutation 230 16 TMB quintile 4 -0.26 -1.19 0.69 1349.09 1.00 519 225 11 5 TRUE 0.22
non-small cell lung cancer KRAS_12 NOTCH2 Any mutation 394 81 TMB quintile 5 -0.58 -1.15 -0.05 1467.98 1.00 767 377 64 17 TRUE 1.49
non-small cell lung cancer KRAS_12 NOTCH2 Any mutation 624 97 TMB overall -0.42 -1.78 1.16 1545.99 1.00 1286 602 75 22 TRUE 0.25
colorectal cancer KRAS_12 TGFBR2 Any mutation 228 47 TMB quintile 5 -0.34 -1.00 0.31 1254.64 1.00 370 214 33 14 TRUE 0.52
colorectal cancer KRAS_12 TGFBR2 Any mutation 19 57 TMB quintile 6 -0.21 -1.14 0.75 1550.96 1.00 74 12 50 7 TRUE 0.18
colorectal cancer KRAS_12 TGFBR2 Any mutation 247 104 TMB overall -0.18 -2.25 2.25 1072.81 1.00 444 226 83 21 TRUE 0.06
colorectal cancer KRAS_12 KMT2A Any mutation 271 16 TMB quintile 4 -0.29 -1.34 0.69 1498.16 1.00 509 266 11 5 FALSE 0.23
colorectal cancer KRAS_12 KMT2A Any mutation 227 43 TMB quintile 5 -0.44 -1.14 0.23 1579.19 1.00 372 215 31 12 FALSE 0.67
colorectal cancer KRAS_12 KMT2A Any mutation 19 84 TMB quintile 6 -0.58 -1.52 0.39 1409.35 1.00 76 12 77 7 FALSE 0.62
non-small cell lung cancer KRAS_12 KMT2A Any mutation 230 16 TMB quintile 4 -0.20 -1.16 0.75 1432.05 1.00 521 225 11 5 FALSE 0.17
non-small cell lung cancer KRAS_12 KMT2A Any mutation 395 80 TMB quintile 5 -0.50 -1.03 0.00 1504.14 1.00 771 377 62 18 FALSE 1.20
uterine cancer KRAS_12 KMT2A Any mutation 49 27 TMB quintile 5 -0.44 -1.62 0.61 1395.63 1.00 191 45 23 4 FALSE 0.36
colorectal cancer KRAS_12 KMT2A Any mutation 517 143 TMB overall -0.43 -2.29 1.45 1387.73 1.00 957 493 119 24 FALSE 0.19
non-small cell lung cancer KRAS_12 KMT2A Any mutation 625 96 TMB overall -0.35 -1.88 1.39 1433.58 1.00 1292 602 73 23 FALSE 0.19
uterine cancer KRAS_12 KMT2A Any mutation 52 103 TMB overall -0.45 -3.57 2.89 1618.80 1.00 219 46 97 6 FALSE 0.11
non-small cell lung cancer KRAS_12 PAK7 Any mutation 230 13 TMB quintile 4 -0.11 -1.16 0.88 1633.77 1.00 520 226 9 4 FALSE 0.08
non-small cell lung cancer KRAS_12 PAK7 Any mutation 395 95 TMB quintile 5 -0.03 -0.48 0.42 1520.77 1.00 766 365 65 30 FALSE 0.05
non-small cell lung cancer KRAS_12 PAK7 Any mutation 625 108 TMB overall -0.09 -1.83 1.61 1575.02 1.00 1286 591 74 34 FALSE 0.04
non-small cell lung cancer KRAS_12 STAG2 Any mutation 230 19 TMB quintile 4 0.02 -0.80 0.77 1542.43 1.00 519 224 13 6 TRUE 0.02
non-small cell lung cancer KRAS_12 STAG2 Any mutation 396 76 TMB quintile 5 0.16 -0.31 0.62 1449.52 1.00 784 369 49 27 TRUE 0.30
non-small cell lung cancer KRAS_12 STAG2 Any mutation 626 95 TMB overall 0.08 -1.06 1.28 1596.35 1.00 1303 593 62 33 TRUE 0.05
non-small cell lung cancer KRAS_12 TERT Any mutation 131 13 TMB quintile 3 0.60 -0.34 1.61 1489.35 1.00 489 125 7 6 TRUE 0.66
non-small cell lung cancer KRAS_12 TERT Any mutation 230 34 TMB quintile 4 0.15 -0.54 0.80 1552.23 1.00 510 219 23 11 TRUE 0.19
non-small cell lung cancer KRAS_12 TERT Any mutation 397 98 TMB quintile 5 0.04 -0.39 0.46 1318.15 1.00 766 366 67 31 TRUE 0.07
non-small cell lung cancer KRAS_12 TERT Any mutation 758 145 TMB overall 0.25 -0.64 1.35 1445.36 1.00 1765 710 97 48 TRUE 0.22
colorectal cancer KRAS_12 BRCA2 Any mutation 271 21 TMB quintile 4 -0.44 -1.46 0.48 1493.29 1.00 505 265 15 6 TRUE 0.45
colorectal cancer KRAS_12 BRCA2 Any mutation 229 48 TMB quintile 5 -0.38 -0.98 0.23 1545.65 1.00 371 215 34 14 TRUE 0.65
colorectal cancer KRAS_12 BRCA2 Any mutation 19 116 TMB quintile 6 -1.23 -2.26 -0.26 1473.59 1.00 68 13 110 6 TRUE 1.80
non-small cell lung cancer KRAS_12 BRCA2 Any mutation 230 23 TMB quintile 4 -0.09 -1.01 0.80 1407.66 1.00 517 223 16 7 TRUE 0.07
non-small cell lung cancer KRAS_12 BRCA2 Any mutation 397 89 TMB quintile 5 -0.23 -0.73 0.24 1502.82 1.00 767 372 64 25 TRUE 0.45
uterine cancer KRAS_12 BRCA2 Any mutation 49 29 TMB quintile 5 -0.56 -1.71 0.48 1566.50 1.00 188 45 25 4 TRUE 0.48
colorectal cancer KRAS_12 BRCA2 Any mutation 519 185 TMB overall -0.66 -2.56 1.21 1386.83 1.00 944 493 159 26 TRUE 0.32
non-small cell lung cancer KRAS_12 BRCA2 Any mutation 627 126 TMB overall -0.59 -3.48 2.25 1493.52 1.00 1293 595 94 32 TRUE 0.17
uterine cancer KRAS_12 BRCA2 Any mutation 52 122 TMB overall -0.60 -3.47 2.49 1449.25 1.00 213 46 116 6 TRUE 0.16
colorectal cancer KRAS_12 NOTCH3 Any mutation 144 12 TMB quintile 3 0.62 -0.51 1.69 1375.25 1.00 337 138 6 6 TRUE 0.54
colorectal cancer KRAS_12 NOTCH3 Any mutation 271 17 TMB quintile 4 0.14 -0.85 1.09 1577.37 1.00 510 264 10 7 TRUE 0.11
colorectal cancer KRAS_12 NOTCH3 Any mutation 227 50 TMB quintile 5 -0.86 -1.57 -0.21 1327.10 1.00 364 217 40 10 TRUE 1.82
colorectal cancer KRAS_12 NOTCH3 Any mutation 19 120 TMB quintile 6 -1.31 -2.27 -0.40 1292.16 1.00 47 12 113 7 TRUE 2.16
non-small cell lung cancer KRAS_12 NOTCH3 Any mutation 230 21 TMB quintile 4 -0.18 -1.22 0.77 1366.61 1.00 518 224 15 6 TRUE 0.14
non-small cell lung cancer KRAS_12 NOTCH3 Any mutation 395 82 TMB quintile 5 -0.23 -0.69 0.27 1431.25 1.00 774 372 59 23 TRUE 0.46
colorectal cancer KRAS_12 NOTCH3 Any mutation 661 199 TMB overall -0.34 -2.02 1.37 1453.12 1.00 1258 631 169 30 TRUE 0.16
non-small cell lung cancer KRAS_12 NOTCH3 Any mutation 625 114 TMB overall -0.54 -3.35 1.94 1466.08 1.00 1301 596 85 29 TRUE 0.17
colorectal cancer KRAS_12 NOTCH4 Any mutation 264 21 TMB quintile 4 -0.64 -1.60 0.28 1616.89 1.00 494 259 16 5 TRUE 0.74
colorectal cancer KRAS_12 NOTCH4 Any mutation 212 37 TMB quintile 5 -0.50 -1.25 0.22 1312.35 1.00 351 202 27 10 TRUE 0.71
colorectal cancer KRAS_12 NOTCH4 Any mutation 20 59 TMB quintile 6 -0.26 -1.20 0.65 1484.43 1.00 80 13 52 7 TRUE 0.22
non-small cell lung cancer KRAS_12 NOTCH4 Any mutation 230 17 TMB quintile 4 -0.71 -1.88 0.30 1467.14 1.00 515 227 14 3 TRUE 0.71
non-small cell lung cancer KRAS_12 NOTCH4 Any mutation 394 107 TMB quintile 5 -0.29 -0.75 0.11 1396.98 1.00 750 365 78 29 TRUE 0.71
colorectal cancer KRAS_12 NOTCH4 Any mutation 496 117 TMB overall -0.45 -1.97 1.16 1348.35 1.00 925 474 95 22 TRUE 0.25
non-small cell lung cancer KRAS_12 NOTCH4 Any mutation 624 124 TMB overall -0.47 -2.27 1.22 1428.26 1.00 1265 592 92 32 TRUE 0.22
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 75 12 TMB quintile 2 0.54 -0.57 1.59 1466.38 1.00 358 71 8 4 FALSE 0.49
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 130 50 TMB quintile 3 0.66 0.05 1.24 1465.21 1.00 463 113 33 17 FALSE 1.53
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 232 129 TMB quintile 4 0.51 0.10 0.90 1412.45 1.00 456 181 78 51 FALSE 1.95
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 399 336 TMB quintile 5 -0.18 -0.45 0.08 1476.94 1.00 603 302 239 97 FALSE 0.74
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 836 527 TMB overall 0.36 -0.61 1.39 1332.64 1.00 1880 667 358 169 FALSE 0.33
non-small cell lung cancer KRAS_12 KDM5C Any mutation 230 16 TMB quintile 4 -0.17 -1.17 0.71 1413.85 1.00 520 226 12 4 FALSE 0.14
non-small cell lung cancer KRAS_12 KDM5C Any mutation 397 70 TMB quintile 5 0.27 -0.20 0.74 1139.34 1.00 788 370 43 27 FALSE 0.58
non-small cell lung cancer KRAS_12 KDM5C Any mutation 627 86 TMB overall 0.07 -1.20 1.26 1617.33 1.00 1308 596 55 31 FALSE 0.04
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 130 33 TMB quintile 3 0.41 -0.38 1.15 1414.20 1.00 475 119 22 11 TRUE 0.53
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 230 43 TMB quintile 4 -0.26 -0.90 0.39 1388.29 1.00 501 219 32 11 TRUE 0.37
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 401 178 TMB quintile 5 -0.71 -1.10 -0.33 1699.07 1.00 695 366 143 35 TRUE 3.57
pancreatic cancer KRAS_12 CDKN2A Any mutation 252 34 TMB quintile 2 0.85 0.21 1.60 1389.07 1.00 90 222 4 30 TRUE 1.77
pancreatic cancer KRAS_12 CDKN2A Any mutation 426 146 TMB quintile 3 1.22 0.72 1.75 1505.76 1.00 92 293 13 133 TRUE 5.39
pancreatic cancer KRAS_12 CDKN2A Any mutation 223 96 TMB quintile 4 1.25 0.64 1.87 1521.07 1.00 54 138 11 85 TRUE 4.31
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 761 254 TMB overall -0.21 -1.22 0.80 1343.53 1.00 1671 704 197 57 TRUE 0.17
pancreatic cancer KRAS_12 CDKN2A Any mutation 901 276 TMB overall 1.10 0.34 1.92 1640.75 1.00 236 653 28 248 TRUE 2.30
non-small cell lung cancer KRAS_12 EPHB1 Any mutation 230 19 TMB quintile 4 0.16 -0.84 1.09 1354.28 1.00 520 223 12 7 FALSE 0.13
non-small cell lung cancer KRAS_12 EPHB1 Any mutation 397 117 TMB quintile 5 -0.68 -1.13 -0.21 1467.24 1.00 739 373 93 24 FALSE 2.38
non-small cell lung cancer KRAS_12 EPHB1 Any mutation 627 152 TMB overall -0.64 -3.80 2.19 1402.80 1.00 1268 596 121 31 FALSE 0.18
uterine cancer KRAS_12 PPP2R1A Any mutation 24 44 TMB quintile 3 -0.45 -1.53 0.57 1350.51 1.00 178 20 40 4 FALSE 0.39
uterine cancer KRAS_12 PPP2R1A Any mutation 39 46 TMB quintile 4 -0.51 -1.38 0.29 1623.82 1.00 151 33 40 6 FALSE 0.61
uterine cancer KRAS_12 PPP2R1A Any mutation 49 25 TMB quintile 5 -0.99 -2.21 0.04 1565.00 1.00 190 47 23 2 FALSE 1.06
uterine cancer KRAS_12 PPP2R1A Any mutation 114 145 TMB overall -0.79 -2.06 0.22 1520.05 1.00 561 102 133 12 FALSE 0.79
colorectal cancer KRAS_12 ERBB3 Any mutation 272 27 TMB quintile 4 0.15 -0.61 0.90 1553.39 1.00 504 261 16 11 TRUE 0.16
colorectal cancer KRAS_12 ERBB3 Any mutation 227 39 TMB quintile 5 -0.08 -0.77 0.56 1625.57 1.00 375 213 25 14 TRUE 0.09
colorectal cancer KRAS_12 ERBB3 Any mutation 18 51 TMB quintile 6 -0.90 -2.11 0.15 1536.36 1.00 87 15 48 3 TRUE 0.90
colorectal cancer KRAS_12 ERBB3 Any mutation 517 117 TMB overall -0.24 -1.86 1.29 1268.66 1.01 966 489 89 28 TRUE 0.12
colorectal cancer KRAS_12 SMAD4 Any mutation 145 51 TMB quintile 3 0.20 -0.31 0.72 1437.30 1.00 312 126 32 19 TRUE 0.35
colorectal cancer KRAS_12 SMAD4 Any mutation 273 129 TMB quintile 4 0.14 -0.24 0.49 1535.70 1.00 443 225 81 48 TRUE 0.35
colorectal cancer KRAS_12 SMAD4 Any mutation 233 138 TMB quintile 5 0.00 -0.38 0.36 1681.46 1.00 321 184 89 49 TRUE 0.00
colorectal cancer KRAS_12 SMAD4 Any mutation 19 31 TMB quintile 6 -0.20 -1.08 0.60 1490.26 1.00 101 16 28 3 TRUE 0.19
non-small cell lung cancer KRAS_12 SMAD4 Any mutation 130 21 TMB quintile 3 -0.44 -1.21 0.28 1481.03 1.00 478 127 18 3 TRUE 0.64
non-small cell lung cancer KRAS_12 SMAD4 Any mutation 230 36 TMB quintile 4 -0.39 -1.01 0.20 1441.50 1.00 508 222 28 8 TRUE 0.68
non-small cell lung cancer KRAS_12 SMAD4 Any mutation 395 49 TMB quintile 5 -0.35 -0.92 0.15 1492.58 1.00 792 382 36 13 TRUE 0.72
pancreatic cancer KRAS_12 SMAD4 Any mutation 252 37 TMB quintile 2 0.38 -0.27 1.14 1399.94 1.00 88 221 6 31 TRUE 0.52
pancreatic cancer KRAS_12 SMAD4 Any mutation 421 119 TMB quintile 3 0.28 -0.23 0.75 1581.43 1.00 85 323 21 98 TRUE 0.60
pancreatic cancer KRAS_12 SMAD4 Any mutation 217 82 TMB quintile 4 0.47 -0.08 1.02 1453.20 1.00 50 150 15 67 TRUE 0.97
pancreatic cancer KRAS_12 SMAD4 Any mutation 35 25 TMB quintile 5 0.62 -0.17 1.41 1545.09 1.00 15 18 8 17 TRUE 0.93
colorectal cancer KRAS_12 SMAD4 Any mutation 670 349 TMB overall 0.03 -0.57 0.68 1431.62 1.00 1177 551 230 119 TRUE 0.04
non-small cell lung cancer KRAS_12 SMAD4 Any mutation 755 106 TMB overall -0.39 -1.04 0.21 1527.72 1.00 1778 731 82 24 TRUE 0.66
pancreatic cancer KRAS_12 SMAD4 Any mutation 925 263 TMB overall 0.44 -0.21 1.16 1383.14 1.00 238 712 50 213 TRUE 0.67
colorectal cancer KRAS_12 ATM Any mutation 274 46 TMB quintile 4 0.23 -0.38 0.82 1464.89 1.00 495 255 27 19 TRUE 0.35
colorectal cancer KRAS_12 ATM Any mutation 232 78 TMB quintile 5 -0.05 -0.57 0.44 1338.46 1.00 353 204 50 28 TRUE 0.08
colorectal cancer KRAS_12 ATM Any mutation 20 94 TMB quintile 6 -0.53 -1.48 0.33 1508.50 1.00 75 12 86 8 TRUE 0.60
non-small cell lung cancer KRAS_12 ATM Any mutation 75 15 TMB quintile 2 0.81 -0.01 1.63 1131.34 1.00 357 70 10 5 TRUE 1.27
non-small cell lung cancer KRAS_12 ATM Any mutation 130 20 TMB quintile 3 0.84 0.07 1.55 1555.80 1.00 484 122 12 8 TRUE 1.58
non-small cell lung cancer KRAS_12 ATM Any mutation 238 76 TMB quintile 4 1.28 0.86 1.74 1347.89 1.00 504 193 31 45 TRUE 7.28
non-small cell lung cancer KRAS_12 ATM Any mutation 408 166 TMB quintile 5 0.70 0.37 1.02 1480.88 1.00 745 332 90 76 TRUE 4.66
uterine cancer KRAS_12 ATM Any mutation 50 46 TMB quintile 5 -0.17 -1.05 0.60 1508.83 1.00 183 42 38 8 TRUE 0.17
colorectal cancer KRAS_12 ATM Any mutation 526 218 TMB overall -0.13 -1.68 1.40 1592.98 1.00 923 471 163 55 TRUE 0.06
non-small cell lung cancer KRAS_12 ATM Any mutation 851 277 TMB overall 0.91 0.22 1.63 1413.03 1.00 2090 717 143 134 TRUE 1.96
uterine cancer KRAS_12 ATM Any mutation 54 147 TMB overall -0.35 -3.26 2.80 1247.13 1.00 203 43 136 11 TRUE 0.09
non-small cell lung cancer KRAS_12 RB1 Any mutation 130 33 TMB quintile 3 -1.33 -2.18 -0.53 1429.42 1.00 465 128 31 2 TRUE 2.69
non-small cell lung cancer KRAS_12 RB1 Any mutation 230 50 TMB quintile 4 -1.24 -1.97 -0.56 1501.61 1.00 488 224 44 6 TRUE 3.24
non-small cell lung cancer KRAS_12 RB1 Any mutation 395 124 TMB quintile 5 -1.08 -1.55 -0.63 1542.18 1.00 728 376 105 19 TRUE 5.20
non-small cell lung cancer KRAS_12 RB1 Any mutation 755 207 TMB overall -1.21 -1.94 -0.55 1466.68 1.00 1681 728 180 27 TRUE 3.15
cancer of unknown primary KRAS_12 KMT2D Any mutation 32 14 TMB quintile 3 -1.29 -3.15 0.16 1502.51 1.00 100 31 13 1 FALSE 0.85
cancer of unknown primary KRAS_12 KMT2D Any mutation 33 11 TMB quintile 4 -0.10 -1.61 1.12 1323.21 1.00 101 30 8 3 FALSE 0.05
cancer of unknown primary KRAS_12 KMT2D Any mutation 34 67 TMB quintile 5 -0.78 -1.60 0.01 1542.49 1.00 104 27 60 7 FALSE 1.18
colorectal cancer KRAS_12 KMT2D Any mutation 271 27 TMB quintile 4 -0.51 -1.38 0.31 1551.01 1.00 501 264 20 7 FALSE 0.62
colorectal cancer KRAS_12 KMT2D Any mutation 233 104 TMB quintile 5 -0.60 -1.07 -0.13 1346.51 1.00 344 207 78 26 FALSE 1.79
colorectal cancer KRAS_12 KMT2D Any mutation 28 245 TMB quintile 6 -0.44 -1.51 0.81 1323.94 1.00 16 3 220 25 FALSE 0.33
non-small cell lung cancer KRAS_12 KMT2D Any mutation 130 15 TMB quintile 3 0.03 -1.25 1.12 1463.43 1.00 485 126 11 4 FALSE 0.02
non-small cell lung cancer KRAS_12 KMT2D Any mutation 230 42 TMB quintile 4 -0.27 -1.00 0.42 1518.10 1.00 504 219 31 11 FALSE 0.35
non-small cell lung cancer KRAS_12 KMT2D Any mutation 399 251 TMB quintile 5 -0.75 -1.09 -0.42 1453.04 1.00 664 349 201 50 FALSE 5.08
uterine cancer KRAS_12 KMT2D Any mutation 39 14 TMB quintile 4 -0.48 -2.08 0.90 1250.76 1.00 179 37 12 2 FALSE 0.27
uterine cancer KRAS_12 KMT2D Any mutation 51 129 TMB quintile 5 -0.50 -1.14 0.12 1456.26 1.00 126 33 111 18 FALSE 0.90
cancer of unknown primary KRAS_12 KMT2D Any mutation 103 123 TMB overall -0.52 -2.22 1.14 1285.87 1.00 309 88 108 15 FALSE 0.26
colorectal cancer KRAS_12 KMT2D Any mutation 532 376 TMB overall -0.50 -2.90 1.94 1524.47 1.00 861 474 318 58 FALSE 0.17
non-small cell lung cancer KRAS_12 KMT2D Any mutation 759 320 TMB overall -0.52 -2.46 1.37 1396.36 1.00 1661 694 255 65 FALSE 0.23
uterine cancer KRAS_12 KMT2D Any mutation 94 252 TMB overall -0.57 -2.57 1.57 1424.04 1.00 322 71 229 23 FALSE 0.23
colorectal cancer KRAS_12 TSC2 Any mutation 230 42 TMB quintile 5 -0.42 -1.16 0.26 1585.27 1.00 373 218 30 12 TRUE 0.62
colorectal cancer KRAS_12 TSC2 Any mutation 19 56 TMB quintile 6 -0.05 -1.06 0.92 1634.08 1.00 86 12 49 7 TRUE 0.03
colorectal cancer KRAS_12 TSC2 Any mutation 249 98 TMB overall -0.21 -2.40 2.10 1508.82 1.00 459 230 79 19 TRUE 0.07
colorectal cancer KRAS_12 APC Any mutation 18 78 TMB quintile 2 -0.91 -1.77 -0.14 1476.08 1.00 55 13 73 5 TRUE 1.55
colorectal cancer KRAS_12 APC Any mutation 173 428 TMB quintile 3 -0.19 -0.55 0.18 1554.34 1.00 106 52 307 121 TRUE 0.52
colorectal cancer KRAS_12 APC Any mutation 382 966 TMB quintile 4 -0.14 -0.47 0.20 1287.33 1.00 94 58 642 324 TRUE 0.38
colorectal cancer KRAS_12 APC Any mutation 369 822 TMB quintile 5 0.38 0.02 0.75 1468.25 1.00 105 46 499 323 TRUE 1.38
colorectal cancer KRAS_12 APC Any mutation 37 225 TMB quintile 6 0.10 -0.63 0.92 1543.10 1.00 43 4 192 33 TRUE 0.10
non-small cell lung cancer KRAS_12 APC Any mutation 130 20 TMB quintile 3 -0.21 -1.08 0.71 1476.88 1.00 481 125 15 5 TRUE 0.19
non-small cell lung cancer KRAS_12 APC Any mutation 230 31 TMB quintile 4 -1.00 -2.06 -0.18 1439.45 1.00 504 227 28 3 TRUE 1.46
non-small cell lung cancer KRAS_12 APC Any mutation 398 101 TMB quintile 5 -0.36 -0.80 0.05 1549.53 1.00 759 372 75 26 TRUE 0.97
uterine cancer KRAS_12 APC Any mutation 49 35 TMB quintile 5 -0.14 -1.13 0.72 1619.92 1.00 193 43 29 6 TRUE 0.11
colorectal cancer KRAS_12 APC Any mutation 979 2519 TMB overall -0.17 -0.84 0.52 1537.18 1.00 403 173 1713 806 TRUE 0.22
non-small cell lung cancer KRAS_12 APC Any mutation 758 152 TMB overall -0.51 -1.44 0.34 1530.22 1.00 1744 724 118 34 TRUE 0.58
uterine cancer KRAS_12 APC Any mutation 54 119 TMB overall 0.00 -2.79 2.98 1530.28 1.00 223 44 109 10 TRUE 0.00
colorectal cancer KRAS_12 ERBB2 Any mutation 271 17 TMB quintile 4 -0.63 -1.75 0.34 1474.56 1.00 507 267 13 4 TRUE 0.64
colorectal cancer KRAS_12 ERBB2 Any mutation 227 33 TMB quintile 5 -0.78 -1.62 -0.01 1666.11 1.00 373 220 26 7 TRUE 1.22
colorectal cancer KRAS_12 ERBB2 Any mutation 18 42 TMB quintile 6 0.35 -0.63 1.33 1438.92 1.00 97 11 35 7 TRUE 0.31
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 75 14 TMB quintile 2 -2.86 -4.39 -1.48 1429.48 1.00 352 75 14 0 TRUE 3.72
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 130 27 TMB quintile 3 -2.56 -4.03 -1.20 1563.66 1.00 471 128 25 2 TRUE 3.36
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 230 32 TMB quintile 4 -2.95 -4.59 -1.70 1456.30 1.00 502 230 32 0 TRUE 4.38
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 395 40 TMB quintile 5 -2.87 -4.38 -1.73 1473.14 1.00 792 394 39 1 TRUE 4.59
colorectal cancer KRAS_12 ERBB2 Any mutation 516 92 TMB overall -0.36 -2.02 1.26 1457.33 1.00 977 498 74 18 TRUE 0.19
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 830 113 TMB overall -2.81 -4.33 -1.65 1443.75 1.00 2117 827 110 3 TRUE 4.58
uterine cancer KRAS_12 JAK1 Any mutation 53 88 TMB quintile 5 0.08 -0.54 0.73 1490.89 1.00 163 36 71 17 TRUE 0.09
uterine cancer KRAS_12 JAK1 Any mutation 56 140 TMB overall 0.51 -2.25 4.15 1489.19 1.00 191 36 120 20 TRUE 0.14
colorectal cancer KRAS_12 ARID2 Any mutation 271 12 TMB quintile 4 -0.60 -1.91 0.60 1387.48 1.00 511 268 9 3 FALSE 0.46
colorectal cancer KRAS_12 ARID2 Any mutation 228 31 TMB quintile 5 0.18 -0.52 0.89 1535.57 1.00 382 215 18 13 FALSE 0.22
colorectal cancer KRAS_12 ARID2 Any mutation 18 66 TMB quintile 6 -0.48 -1.50 0.50 1575.56 1.00 76 12 60 6 FALSE 0.46
non-small cell lung cancer KRAS_12 ARID2 Any mutation 130 19 TMB quintile 3 -0.80 -2.05 0.14 1530.59 1.00 478 129 18 1 FALSE 0.76
non-small cell lung cancer KRAS_12 ARID2 Any mutation 230 35 TMB quintile 4 -0.10 -0.80 0.57 1588.20 1.00 510 219 24 11 FALSE 0.11
non-small cell lung cancer KRAS_12 ARID2 Any mutation 396 111 TMB quintile 5 -0.22 -0.67 0.20 1577.16 1.00 758 365 80 31 FALSE 0.51
colorectal cancer KRAS_12 ARID2 Any mutation 517 109 TMB overall -0.31 -2.26 1.64 1335.03 1.00 969 495 87 22 FALSE 0.13
non-small cell lung cancer KRAS_12 ARID2 Any mutation 756 165 TMB overall -0.37 -1.30 0.46 1497.57 1.00 1746 713 122 43 FALSE 0.39
colorectal cancer KRAS_12 MTOR Any mutation 271 19 TMB quintile 4 1.00 0.09 1.97 1620.75 1.00 513 259 7 12 TRUE 1.48
colorectal cancer KRAS_12 MTOR Any mutation 228 40 TMB quintile 5 -0.22 -0.91 0.41 1411.14 1.00 372 215 27 13 TRUE 0.28
colorectal cancer KRAS_12 MTOR Any mutation 20 70 TMB quintile 6 -0.61 -1.61 0.29 1372.24 1.00 78 14 64 6 TRUE 0.67
non-small cell lung cancer KRAS_12 MTOR Any mutation 130 14 TMB quintile 3 -0.34 -1.32 0.56 1399.95 1.00 484 128 12 2 TRUE 0.33
non-small cell lung cancer KRAS_12 MTOR Any mutation 230 21 TMB quintile 4 -0.40 -1.24 0.36 1354.25 1.00 516 226 17 4 TRUE 0.48
non-small cell lung cancer KRAS_12 MTOR Any mutation 397 70 TMB quintile 5 0.10 -0.40 0.58 1290.96 1.00 783 372 45 25 TRUE 0.16
colorectal cancer KRAS_12 MTOR Any mutation 519 129 TMB overall 0.04 -2.02 2.00 1576.15 1.00 963 488 98 31 TRUE 0.01
non-small cell lung cancer KRAS_12 MTOR Any mutation 757 105 TMB overall -0.20 -1.11 0.58 1294.36 1.00 1783 726 74 31 TRUE 0.20
colorectal cancer KRAS_12 NOTCH1 Any mutation 227 48 TMB quintile 5 -1.29 -2.22 -0.53 1388.06 1.00 362 220 41 7 TRUE 2.59
colorectal cancer KRAS_12 NOTCH1 Any mutation 24 112 TMB quintile 6 0.34 -0.55 1.35 1342.57 1.00 60 7 95 17 TRUE 0.33
non-small cell lung cancer KRAS_12 NOTCH1 Any mutation 230 15 TMB quintile 4 -0.68 -1.87 0.36 1538.46 1.00 520 227 12 3 TRUE 0.64
non-small cell lung cancer KRAS_12 NOTCH1 Any mutation 396 97 TMB quintile 5 -0.46 -0.94 0.00 1417.57 1.00 759 373 74 23 TRUE 1.21
colorectal cancer KRAS_12 NOTCH1 Any mutation 251 160 TMB overall -0.41 -2.98 2.39 1433.22 1.00 422 227 136 24 TRUE 0.12
non-small cell lung cancer KRAS_12 NOTCH1 Any mutation 626 112 TMB overall -0.54 -2.14 1.19 1561.13 1.00 1279 600 86 26 TRUE 0.28
colorectal cancer KRAS_12 SETD2 Any mutation 144 11 TMB quintile 3 -2.88 -6.22 -0.71 1483.93 1.00 333 144 11 0 FALSE 1.41
colorectal cancer KRAS_12 SETD2 Any mutation 227 31 TMB quintile 5 -1.84 -3.17 -0.77 1484.46 1.00 374 224 28 3 FALSE 2.59
colorectal cancer KRAS_12 SETD2 Any mutation 20 64 TMB quintile 6 -1.00 -2.10 0.03 1400.58 1.00 80 15 59 5 FALSE 1.19
non-small cell lung cancer KRAS_12 SETD2 Any mutation 75 14 TMB quintile 2 -0.88 -2.34 0.18 1325.72 1.00 352 75 14 0 FALSE 0.77
non-small cell lung cancer KRAS_12 SETD2 Any mutation 131 22 TMB quintile 3 -0.71 -1.75 0.14 1595.62 1.00 481 129 20 2 FALSE 0.83
non-small cell lung cancer KRAS_12 SETD2 Any mutation 231 59 TMB quintile 4 -0.27 -0.86 0.27 1278.88 1.00 496 216 44 15 FALSE 0.47
non-small cell lung cancer KRAS_12 SETD2 Any mutation 402 110 TMB quintile 5 0.03 -0.38 0.42 1369.27 1.00 765 364 72 38 FALSE 0.06
colorectal cancer KRAS_12 SETD2 Any mutation 391 106 TMB overall -1.84 -3.91 0.07 1563.19 1.00 787 383 98 8 FALSE 1.12
non-small cell lung cancer KRAS_12 SETD2 Any mutation 839 205 TMB overall -0.46 -1.31 0.25 1414.99 1.00 2094 784 150 55 FALSE 0.61
non-small cell lung cancer KRAS_12 PBRM1 Any mutation 232 21 TMB quintile 4 0.26 -0.59 1.16 1272.62 1.00 521 223 12 9 TRUE 0.25
non-small cell lung cancer KRAS_12 PBRM1 Any mutation 395 79 TMB quintile 5 -0.36 -0.92 0.14 1139.64 1.00 777 376 60 19 TRUE 0.74
non-small cell lung cancer KRAS_12 PBRM1 Any mutation 627 100 TMB overall -0.06 -1.62 1.33 1548.15 1.00 1298 599 72 28 TRUE 0.03
colorectal cancer KRAS_12 EPHA3 Any mutation 272 17 TMB quintile 4 -0.38 -1.42 0.58 1581.51 1.00 508 267 12 5 FALSE 0.34
colorectal cancer KRAS_12 EPHA3 Any mutation 227 41 TMB quintile 5 -0.14 -0.84 0.50 1498.29 1.00 373 213 27 14 FALSE 0.17
colorectal cancer KRAS_12 EPHA3 Any mutation 18 44 TMB quintile 6 -0.45 -1.58 0.59 1511.84 1.00 93 14 40 4 FALSE 0.39
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 130 15 TMB quintile 3 0.45 -0.66 1.48 1471.65 1.00 486 125 10 5 FALSE 0.38
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 230 28 TMB quintile 4 0.49 -0.29 1.26 1439.05 1.00 516 218 16 12 FALSE 0.68
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 402 182 TMB quintile 5 -0.06 -0.40 0.29 1501.24 1.00 714 345 125 57 FALSE 0.13
colorectal cancer KRAS_12 EPHA3 Any mutation 517 102 TMB overall -0.34 -1.77 1.21 1337.68 1.00 974 494 79 23 FALSE 0.19
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 762 237 TMB overall 0.03 -1.93 1.89 1294.55 1.00 1724 688 163 74 FALSE 0.01
non-small cell lung cancer KRAS_12 KDR Any mutation 230 21 TMB quintile 4 0.52 -0.34 1.43 1386.26 1.00 521 220 11 10 TRUE 0.63
non-small cell lung cancer KRAS_12 KDR Any mutation 398 109 TMB quintile 5 -0.17 -0.62 0.27 1499.05 1.00 752 367 78 31 TRUE 0.34
non-small cell lung cancer KRAS_12 KDR Any mutation 628 130 TMB overall 0.17 -1.49 1.87 1271.63 1.00 1273 587 89 41 TRUE 0.08
colorectal cancer KRAS_12 PTCH1 Any mutation 227 35 TMB quintile 5 -1.11 -2.11 -0.26 1213.33 1.00 372 221 29 6 TRUE 1.82
colorectal cancer KRAS_12 PTCH1 Any mutation 19 99 TMB quintile 6 -0.28 -1.20 0.70 1493.77 1.00 65 9 89 10 TRUE 0.25
colorectal cancer KRAS_12 PTCH1 Any mutation 246 134 TMB overall -0.64 -3.48 2.33 1558.85 1.00 437 230 118 16 TRUE 0.18
colorectal cancer KRAS_12 TET1 Any mutation 212 26 TMB quintile 5 -0.92 -1.92 -0.01 1454.61 1.00 358 207 21 5 FALSE 1.17
colorectal cancer KRAS_12 TET1 Any mutation 19 67 TMB quintile 6 -0.32 -1.32 0.61 1551.69 1.00 83 12 60 7 FALSE 0.28
non-small cell lung cancer KRAS_12 TET1 Any mutation 230 16 TMB quintile 4 -0.78 -2.18 0.43 1450.34 1.00 516 227 13 3 FALSE 0.60
non-small cell lung cancer KRAS_12 TET1 Any mutation 396 89 TMB quintile 5 -0.18 -0.66 0.30 1459.65 1.00 768 370 63 26 FALSE 0.33
colorectal cancer KRAS_12 TET1 Any mutation 231 93 TMB overall -0.54 -3.09 1.99 1526.30 1.00 441 219 81 12 FALSE 0.18
non-small cell lung cancer KRAS_12 TET1 Any mutation 626 120 TMB overall -0.89 -3.88 2.10 1607.41 1.00 1289 597 91 29 FALSE 0.26
uterine cancer KRAS_12 FGFR2 Any mutation 39 23 TMB quintile 4 -1.59 -3.43 -0.07 1455.43 1.00 170 37 21 2 TRUE 1.25
uterine cancer KRAS_12 FGFR2 Any mutation 49 52 TMB quintile 5 -2.45 -4.26 -1.10 1411.88 1.00 168 48 51 1 TRUE 2.60
uterine cancer KRAS_12 FGFR2 Any mutation 90 93 TMB overall -2.09 -4.04 -0.38 1488.91 1.00 384 87 90 3 TRUE 1.68
non-small cell lung cancer KRAS_12 TBX3 Any mutation 230 11 TMB quintile 4 0.05 -1.05 1.18 1555.28 1.00 525 226 7 4 FALSE 0.03
non-small cell lung cancer KRAS_12 TBX3 Any mutation 395 108 TMB quintile 5 -0.21 -0.65 0.24 1404.26 1.00 758 365 78 30 FALSE 0.46
non-small cell lung cancer KRAS_12 TBX3 Any mutation 625 119 TMB overall -0.08 -2.02 1.97 1429.38 1.00 1283 591 85 34 FALSE 0.03
colorectal cancer KRAS_12 SMAD3 Any mutation 144 12 TMB quintile 3 -0.40 -1.58 0.66 1437.81 1.00 333 142 10 2 TRUE 0.31
colorectal cancer KRAS_12 SMAD3 Any mutation 274 27 TMB quintile 4 0.33 -0.39 1.04 1558.86 1.00 507 262 15 12 TRUE 0.44
colorectal cancer KRAS_12 SMAD3 Any mutation 233 44 TMB quintile 5 0.54 -0.05 1.12 1349.28 1.00 378 211 22 22 TRUE 1.16
colorectal cancer KRAS_12 SMAD3 Any mutation 19 23 TMB quintile 6 0.54 -0.51 1.46 1452.78 1.00 107 14 18 5 TRUE 0.55
colorectal cancer KRAS_12 SMAD3 Any mutation 670 106 TMB overall 0.26 -0.69 1.27 1583.23 1.00 1325 629 65 41 TRUE 0.22
non-small cell lung cancer KRAS_12 NTRK3 Any mutation 232 31 TMB quintile 4 1.16 0.42 1.88 1438.91 1.00 520 214 13 18 FALSE 2.73
non-small cell lung cancer KRAS_12 NTRK3 Any mutation 399 144 TMB quintile 5 0.08 -0.30 0.44 1388.46 1.00 742 350 95 49 FALSE 0.18
non-small cell lung cancer KRAS_12 NTRK3 Any mutation 631 195 TMB overall -0.05 -3.33 3.15 1248.12 1.00 1269 564 128 67 FALSE 0.01
colorectal cancer KRAS_12 GRIN2A Any mutation 271 30 TMB quintile 4 -0.32 -1.11 0.44 1330.08 1.00 499 262 21 9 FALSE 0.37
colorectal cancer KRAS_12 GRIN2A Any mutation 228 42 TMB quintile 5 -0.31 -1.00 0.35 1267.43 1.00 370 215 29 13 FALSE 0.44
colorectal cancer KRAS_12 GRIN2A Any mutation 18 59 TMB quintile 6 -1.13 -2.35 -0.07 1578.91 1.00 81 15 56 3 FALSE 1.28
non-small cell lung cancer KRAS_12 GRIN2A Any mutation 130 17 TMB quintile 3 0.13 -0.70 1.01 1412.84 1.00 484 125 12 5 FALSE 0.12
non-small cell lung cancer KRAS_12 GRIN2A Any mutation 230 39 TMB quintile 4 0.00 -0.68 0.59 1483.76 1.00 506 218 27 12 FALSE 0.00
non-small cell lung cancer KRAS_12 GRIN2A Any mutation 399 124 TMB quintile 5 -0.12 -0.53 0.26 1505.98 1.00 745 363 88 36 FALSE 0.27
colorectal cancer KRAS_12 GRIN2A Any mutation 517 131 TMB overall -0.57 -2.16 1.02 1489.79 1.00 950 492 106 25 FALSE 0.33
non-small cell lung cancer KRAS_12 GRIN2A Any mutation 759 180 TMB overall 0.01 -0.81 0.90 1565.06 1.00 1735 706 127 53 FALSE 0.01
uterine cancer KRAS_12 CTCF Any mutation 39 12 TMB quintile 4 -0.32 -1.99 1.07 1532.20 1.00 180 37 10 2 FALSE 0.17
uterine cancer KRAS_12 CTCF Any mutation 51 103 TMB quintile 5 0.14 -0.49 0.75 1498.03 1.00 136 30 82 21 FALSE 0.18
uterine cancer KRAS_12 CTCF Any mutation 92 163 TMB overall -0.29 -2.33 1.83 1435.03 1.00 342 68 139 24 FALSE 0.11
non-small cell lung cancer KRAS_12 STK11 Any mutation 75 12 TMB quintile 2 1.45 0.49 2.48 1390.38 1.00 361 68 5 7 TRUE 2.39
non-small cell lung cancer KRAS_12 STK11 Any mutation 132 78 TMB quintile 3 1.19 0.71 1.66 1474.37 1.00 451 99 45 33 TRUE 5.81
non-small cell lung cancer KRAS_12 STK11 Any mutation 233 161 TMB quintile 4 1.47 1.12 1.81 1417.81 1.00 463 141 69 92 TRUE 14.88
non-small cell lung cancer KRAS_12 STK11 Any mutation 399 283 TMB quintile 5 0.22 -0.06 0.50 1406.91 1.00 655 299 183 100 TRUE 0.92
non-small cell lung cancer KRAS_12 STK11 Any mutation 839 534 TMB overall 1.06 0.14 2.03 1240.78 1.00 1930 607 302 232 TRUE 1.52
colorectal cancer KRAS_12 ASXL1 Any mutation 271 15 TMB quintile 4 -0.27 -1.29 0.68 1626.50 1.00 510 266 10 5 TRUE 0.22
colorectal cancer KRAS_12 ASXL1 Any mutation 227 30 TMB quintile 5 -0.71 -1.60 0.10 1526.02 1.00 377 220 23 7 TRUE 1.01
colorectal cancer KRAS_12 ASXL1 Any mutation 18 57 TMB quintile 6 -0.87 -2.08 0.15 1451.51 1.00 80 14 53 4 TRUE 0.88
colorectal cancer KRAS_12 ASXL1 Any mutation 516 102 TMB overall -0.58 -2.28 1.10 1419.31 1.00 967 500 86 16 TRUE 0.30
colorectal cancer KRAS_12 EP300 Any mutation 227 39 TMB quintile 5 -0.73 -1.53 0.01 1444.67 1.00 371 218 30 9 TRUE 1.20
colorectal cancer KRAS_12 EP300 Any mutation 20 72 TMB quintile 6 -0.50 -1.47 0.46 1337.30 1.00 79 13 65 7 TRUE 0.51
non-small cell lung cancer KRAS_12 EP300 Any mutation 396 77 TMB quintile 5 -0.27 -0.78 0.22 1416.17 1.00 777 375 56 21 TRUE 0.53
uterine cancer KRAS_12 EP300 Any mutation 50 39 TMB quintile 5 0.07 -0.82 0.87 1284.33 1.00 185 42 31 8 TRUE 0.06
colorectal cancer KRAS_12 EP300 Any mutation 247 111 TMB overall -0.58 -2.93 1.71 1506.15 1.00 450 231 95 16 TRUE 0.21
non-small cell lung cancer KRAS_12 EP300 Any mutation 396 77 TMB overall -0.26 -4.64 4.20 1369.58 1.00 777 375 56 21 TRUE 0.05
uterine cancer KRAS_12 EP300 Any mutation 53 92 TMB overall -0.05 -2.71 2.78 1655.75 1.00 216 43 82 10 TRUE 0.01
colorectal cancer KRAS_12 ERBB4 Any mutation 271 22 TMB quintile 4 0.02 -0.82 0.82 1547.62 1.00 507 263 14 8 TRUE 0.02
colorectal cancer KRAS_12 ERBB4 Any mutation 228 45 TMB quintile 5 0.15 -0.46 0.77 1616.48 1.00 373 210 27 18 TRUE 0.20
colorectal cancer KRAS_12 ERBB4 Any mutation 19 61 TMB quintile 6 0.12 -0.80 1.05 1530.01 1.00 86 11 53 8 TRUE 0.10
non-small cell lung cancer KRAS_12 ERBB4 Any mutation 230 25 TMB quintile 4 -0.04 -0.93 0.79 1461.90 1.00 515 222 17 8 TRUE 0.04
non-small cell lung cancer KRAS_12 ERBB4 Any mutation 399 148 TMB quintile 5 -0.65 -1.09 -0.25 1599.96 1.00 732 368 117 31 TRUE 2.64
colorectal cancer KRAS_12 ERBB4 Any mutation 518 128 TMB overall 0.09 -1.36 1.70 1558.56 1.00 966 484 94 34 TRUE 0.04
non-small cell lung cancer KRAS_12 ERBB4 Any mutation 629 185 TMB overall -0.64 -3.38 2.22 1444.21 1.00 1256 590 146 39 TRUE 0.20
colorectal cancer KRAS_12 MED12 Any mutation 272 18 TMB quintile 4 0.48 -0.46 1.40 1426.29 1.00 511 263 9 9 TRUE 0.51
colorectal cancer KRAS_12 MED12 Any mutation 227 28 TMB quintile 5 0.08 -0.71 0.82 1471.05 1.00 384 216 17 11 TRUE 0.07
colorectal cancer KRAS_12 MED12 Any mutation 19 59 TMB quintile 6 -0.86 -2.08 0.13 1401.91 1.00 80 15 55 4 TRUE 0.88
non-small cell lung cancer KRAS_12 MED12 Any mutation 130 23 TMB quintile 3 -0.35 -1.17 0.42 1360.84 1.00 477 126 19 4 TRUE 0.41
non-small cell lung cancer KRAS_12 MED12 Any mutation 230 32 TMB quintile 4 -0.25 -0.91 0.44 1541.02 1.00 509 221 23 9 TRUE 0.34
non-small cell lung cancer KRAS_12 MED12 Any mutation 398 101 TMB quintile 5 -0.40 -0.82 0.03 1211.46 1.00 757 374 77 24 TRUE 1.14
uterine cancer KRAS_12 MED12 Any mutation 12 13 TMB quintile 2 -1.61 -4.18 0.32 1416.89 1.00 120 12 13 0 TRUE 0.81
uterine cancer KRAS_12 MED12 Any mutation 24 16 TMB quintile 3 -0.41 -2.10 1.03 1523.01 1.00 203 22 14 2 TRUE 0.22
uterine cancer KRAS_12 MED12 Any mutation 39 20 TMB quintile 4 -1.41 -3.22 0.10 1562.17 1.00 171 38 19 1 TRUE 1.03
uterine cancer KRAS_12 MED12 Any mutation 49 31 TMB quintile 5 -0.19 -1.22 0.72 1396.20 1.00 192 43 25 6 TRUE 0.16
colorectal cancer KRAS_12 MED12 Any mutation 518 105 TMB overall -0.08 -1.77 1.72 1213.94 1.00 975 494 81 24 TRUE 0.03
non-small cell lung cancer KRAS_12 MED12 Any mutation 758 156 TMB overall -0.34 -1.04 0.43 1485.53 1.00 1743 721 119 37 TRUE 0.44
uterine cancer KRAS_12 MED12 Any mutation 126 138 TMB overall -1.10 -2.58 0.26 1614.28 1.00 717 117 129 9 TRUE 0.87
non-small cell lung cancer KRAS_12 RBM10 Any mutation 75 29 TMB quintile 2 0.24 -0.46 0.86 1433.39 1.00 342 70 24 5 FALSE 0.33
non-small cell lung cancer KRAS_12 RBM10 Any mutation 130 46 TMB quintile 3 0.36 -0.16 0.90 1428.79 1.00 463 118 34 12 FALSE 0.75
non-small cell lung cancer KRAS_12 RBM10 Any mutation 231 90 TMB quintile 4 0.74 0.33 1.12 1411.98 1.00 484 189 48 42 FALSE 3.54
non-small cell lung cancer KRAS_12 RBM10 Any mutation 402 200 TMB quintile 5 0.64 0.36 0.94 1354.14 1.00 728 313 111 89 FALSE 4.81
non-small cell lung cancer KRAS_12 RBM10 Any mutation 838 365 TMB overall 0.49 -0.03 1.00 1397.44 1.00 2017 690 217 148 FALSE 1.31
colorectal cancer KRAS_12 NF1 Any mutation 271 13 TMB quintile 4 -1.75 -3.73 -0.26 1497.82 1.00 509 270 12 1 TRUE 1.31
colorectal cancer KRAS_12 NF1 Any mutation 228 34 TMB quintile 5 -0.13 -0.86 0.57 1432.00 1.00 377 216 22 12 TRUE 0.14
colorectal cancer KRAS_12 NF1 Any mutation 19 86 TMB quintile 6 -0.66 -1.63 0.28 1189.40 1.00 77 12 79 7 TRUE 0.74
non-small cell lung cancer KRAS_12 NF1 Any mutation 130 25 TMB quintile 3 -0.96 -2.09 0.02 1619.52 1.00 475 127 22 3 TRUE 1.15
non-small cell lung cancer KRAS_12 NF1 Any mutation 230 59 TMB quintile 4 -1.48 -2.34 -0.68 1575.78 1.00 486 225 54 5 TRUE 3.42
non-small cell lung cancer KRAS_12 NF1 Any mutation 399 216 TMB quintile 5 -0.81 -1.17 -0.45 1262.00 1.00 685 358 175 41 TRUE 5.30
uterine cancer KRAS_12 NF1 Any mutation 49 38 TMB quintile 5 -0.57 -1.61 0.36 1444.98 1.00 187 44 33 5 TRUE 0.59
colorectal cancer KRAS_12 NF1 Any mutation 518 133 TMB overall -0.80 -2.66 1.14 1367.85 1.00 963 498 113 20 TRUE 0.38
non-small cell lung cancer KRAS_12 NF1 Any mutation 759 300 TMB overall -1.07 -2.03 -0.13 1504.34 1.00 1646 710 251 49 TRUE 1.50
uterine cancer KRAS_12 NF1 Any mutation 51 111 TMB overall -0.86 -3.72 2.24 1545.92 1.00 215 45 105 6 TRUE 0.25
non-small cell lung cancer KRAS_12 FLT1 Any mutation 230 21 TMB quintile 4 0.53 -0.35 1.40 1524.35 1.00 522 220 11 10 FALSE 0.62
non-small cell lung cancer KRAS_12 FLT1 Any mutation 398 99 TMB quintile 5 -0.21 -0.70 0.22 1573.09 1.00 763 371 72 27 FALSE 0.44
non-small cell lung cancer KRAS_12 FLT1 Any mutation 628 120 TMB overall 0.16 -1.43 1.80 1545.13 1.00 1285 591 83 37 FALSE 0.07
uterine cancer KRAS_12 RASA1 Any mutation 49 25 TMB quintile 5 -0.42 -1.75 0.67 1482.06 1.00 194 45 21 4 FALSE 0.30
uterine cancer KRAS_12 RASA1 Any mutation 51 95 TMB overall -1.68 -5.87 2.11 1617.61 1.00 221 47 91 4 FALSE 0.41
colorectal cancer KRAS_12 EPHA5 Any mutation 271 18 TMB quintile 4 -0.76 -1.94 0.29 1516.89 1.00 506 267 14 4 FALSE 0.78
colorectal cancer KRAS_12 EPHA5 Any mutation 228 52 TMB quintile 5 -0.13 -0.73 0.47 1694.67 1.00 367 210 34 18 FALSE 0.18
colorectal cancer KRAS_12 EPHA5 Any mutation 18 66 TMB quintile 6 -0.96 -2.17 0.12 1412.82 1.00 84 14 62 4 FALSE 1.01
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 230 48 TMB quintile 4 0.20 -0.38 0.81 1152.81 1.00 502 213 31 17 FALSE 0.30
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 399 191 TMB quintile 5 0.04 -0.29 0.35 1539.92 1.00 715 336 128 63 FALSE 0.11
colorectal cancer KRAS_12 EPHA5 Any mutation 517 136 TMB overall -0.61 -2.27 1.06 1661.25 1.00 957 491 110 26 FALSE 0.32
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 629 250 TMB overall -0.27 -2.67 1.85 1642.40 1.00 1227 549 170 80 FALSE 0.09
colorectal cancer KRAS_12 AR Any mutation 271 21 TMB quintile 4 -0.88 -1.93 0.07 1606.97 1.00 503 267 17 4 TRUE 1.03
colorectal cancer KRAS_12 AR Any mutation 227 34 TMB quintile 5 -1.01 -1.93 -0.22 1447.22 1.00 373 221 28 6 TRUE 1.66
colorectal cancer KRAS_12 AR Any mutation 18 55 TMB quintile 6 0.20 -0.77 1.11 1540.14 1.00 87 10 47 8 TRUE 0.17
non-small cell lung cancer KRAS_12 AR Any mutation 230 16 TMB quintile 4 0.31 -0.56 1.28 1425.07 1.00 523 223 9 7 TRUE 0.29
non-small cell lung cancer KRAS_12 AR Any mutation 398 77 TMB quintile 5 -0.14 -0.64 0.37 1686.87 1.00 778 376 55 22 TRUE 0.24
colorectal cancer KRAS_12 AR Any mutation 516 110 TMB overall -0.59 -2.28 1.05 1385.53 1.00 963 498 92 18 TRUE 0.32
non-small cell lung cancer KRAS_12 AR Any mutation 628 93 TMB overall 0.05 -1.42 1.58 1458.51 1.00 1301 599 64 29 TRUE 0.03
colorectal cancer KRAS_12 ROS1 Any mutation 271 14 TMB quintile 4 -1.39 -2.98 -0.05 1449.56 1.00 508 269 12 2 TRUE 1.24
colorectal cancer KRAS_12 ROS1 Any mutation 227 24 TMB quintile 5 -1.23 -2.36 -0.25 1502.53 1.00 379 223 20 4 TRUE 1.60
colorectal cancer KRAS_12 ROS1 Any mutation 18 61 TMB quintile 6 -1.73 -3.30 -0.52 1537.93 1.00 87 16 59 2 TRUE 1.81
non-small cell lung cancer KRAS_12 ROS1 Any mutation 230 13 TMB quintile 4 -2.85 -7.18 -0.81 1459.03 1.00 519 230 13 0 TRUE 1.06
non-small cell lung cancer KRAS_12 ROS1 Any mutation 396 80 TMB quintile 5 -1.14 -1.78 -0.51 1412.68 1.00 764 384 68 12 TRUE 3.21
colorectal cancer KRAS_12 ROS1 Any mutation 516 99 TMB overall -1.45 -3.31 0.24 1241.95 1.00 974 508 91 8 TRUE 0.96
non-small cell lung cancer KRAS_12 ROS1 Any mutation 626 93 TMB overall -1.86 -4.86 0.32 1478.31 1.00 1283 614 81 12 TRUE 0.84
colorectal cancer KRAS_12 PIK3CG Any mutation 271 16 TMB quintile 4 -0.53 -1.64 0.50 1507.69 1.00 508 267 12 4 FALSE 0.48
colorectal cancer KRAS_12 PIK3CG Any mutation 227 38 TMB quintile 5 0.09 -0.59 0.77 1447.68 1.00 376 212 23 15 FALSE 0.11
colorectal cancer KRAS_12 PIK3CG Any mutation 20 45 TMB quintile 6 -0.28 -1.40 0.70 1533.74 1.00 96 15 40 5 FALSE 0.23
non-small cell lung cancer KRAS_12 PIK3CG Any mutation 230 16 TMB quintile 4 0.15 -0.86 1.08 1463.86 1.00 522 224 10 6 FALSE 0.12
non-small cell lung cancer KRAS_12 PIK3CG Any mutation 399 150 TMB quintile 5 -0.21 -0.61 0.18 1504.92 1.00 734 357 108 42 FALSE 0.55
colorectal cancer KRAS_12 PIK3CG Any mutation 518 99 TMB overall -0.23 -1.84 1.31 1541.21 1.00 980 494 75 24 FALSE 0.11
non-small cell lung cancer KRAS_12 PIK3CG Any mutation 629 166 TMB overall -0.01 -1.92 2.20 1441.73 1.00 1256 581 118 48 FALSE 0.00
non-small cell lung cancer KRAS_12 EGFR Any mutation 75 200 TMB quintile 2 -5.21 -8.31 -3.41 1553.87 1.00 188 75 200 0 TRUE 4.25
non-small cell lung cancer KRAS_12 EGFR Any mutation 130 287 TMB quintile 3 -5.47 -8.52 -3.70 1345.05 1.00 266 130 287 0 TRUE 4.90
non-small cell lung cancer KRAS_12 EGFR Any mutation 230 256 TMB quintile 4 -4.49 -6.02 -3.41 1490.33 1.00 342 228 254 2 TRUE 11.28
non-small cell lung cancer KRAS_12 EGFR Any mutation 395 175 TMB quintile 5 -2.05 -2.73 -1.45 1157.05 1.00 707 381 161 14 TRUE 9.29
non-small cell lung cancer KRAS_12 EGFR Any mutation 830 918 TMB overall -4.20 -6.05 -2.84 1418.43 1.00 1503 814 902 16 TRUE 6.52
colorectal cancer KRAS_12 ARID1B Any mutation 271 13 TMB quintile 4 -0.47 -1.69 0.72 1578.69 1.00 512 267 9 4 TRUE 0.35
colorectal cancer KRAS_12 ARID1B Any mutation 228 46 TMB quintile 5 -1.11 -1.91 -0.39 1548.42 1.00 363 220 38 8 TRUE 2.41
colorectal cancer KRAS_12 ARID1B Any mutation 18 79 TMB quintile 6 -2.14 -3.68 -0.90 1413.15 1.00 65 16 77 2 TRUE 2.71
non-small cell lung cancer KRAS_12 ARID1B Any mutation 130 11 TMB quintile 3 -0.38 -1.58 0.66 1379.75 1.00 487 128 9 2 TRUE 0.30
non-small cell lung cancer KRAS_12 ARID1B Any mutation 230 16 TMB quintile 4 -0.75 -1.94 0.19 1379.49 1.00 519 228 14 2 TRUE 0.81
non-small cell lung cancer KRAS_12 ARID1B Any mutation 397 77 TMB quintile 5 -0.03 -0.52 0.46 1517.89 1.00 779 372 52 25 TRUE 0.04
uterine cancer KRAS_12 ARID1B Any mutation 52 59 TMB quintile 5 0.47 -0.23 1.14 1481.06 1.00 175 37 44 15 TRUE 0.74
colorectal cancer KRAS_12 ARID1B Any mutation 517 138 TMB overall -1.23 -3.14 0.75 1494.92 1.00 940 503 124 14 TRUE 0.67
non-small cell lung cancer KRAS_12 ARID1B Any mutation 757 104 TMB overall -0.39 -1.43 0.64 1367.52 1.00 1785 728 75 29 TRUE 0.34
uterine cancer KRAS_12 ARID1B Any mutation 54 107 TMB overall 0.72 -2.04 4.34 1558.21 1.00 205 37 90 17 TRUE 0.18
non-small cell lung cancer KRAS_12 MET Any mutation 75 21 TMB quintile 2 -0.86 -1.94 0.09 1662.00 1.00 348 73 19 2 TRUE 1.05
non-small cell lung cancer KRAS_12 MET Any mutation 130 30 TMB quintile 3 -1.08 -2.15 -0.21 1511.76 1.00 474 128 28 2 TRUE 1.53
non-small cell lung cancer KRAS_12 MET Any mutation 230 34 TMB quintile 4 -1.47 -2.79 -0.53 1499.53 1.00 505 229 33 1 TRUE 2.03
non-small cell lung cancer KRAS_12 MET Any mutation 395 47 TMB quintile 5 -0.17 -0.80 0.47 1604.47 1.00 800 378 30 17 TRUE 0.21
non-small cell lung cancer KRAS_12 MET Any mutation 830 132 TMB overall -0.88 -1.73 -0.13 1543.41 1.00 2127 808 110 22 TRUE 1.51
colorectal cancer KRAS_12 BRAF Any mutation 144 27 TMB quintile 3 -2.69 -4.29 -1.41 1383.98 1.00 317 143 26 1 TRUE 3.50
colorectal cancer KRAS_12 BRAF Any mutation 271 60 TMB quintile 4 -2.81 -4.08 -1.77 1502.16 1.00 462 269 58 2 TRUE 5.68
colorectal cancer KRAS_12 BRAF Any mutation 228 104 TMB quintile 5 -2.41 -3.21 -1.72 1519.53 1.00 304 221 97 7 TRUE 9.54
colorectal cancer KRAS_12 BRAF Any mutation 18 59 TMB quintile 6 -2.71 -4.31 -1.35 1596.45 1.00 75 17 58 1 TRUE 3.51
non-small cell lung cancer KRAS_12 BRAF Any mutation 75 11 TMB quintile 2 -1.68 -3.47 -0.41 1456.35 1.00 355 75 11 0 TRUE 1.56
non-small cell lung cancer KRAS_12 BRAF Any mutation 130 13 TMB quintile 3 -1.77 -3.37 -0.52 1259.68 1.00 483 130 13 0 TRUE 1.81
non-small cell lung cancer KRAS_12 BRAF Any mutation 230 46 TMB quintile 4 -1.21 -2.04 -0.50 1462.90 1.00 493 224 40 6 TRUE 2.65
non-small cell lung cancer KRAS_12 BRAF Any mutation 395 101 TMB quintile 5 -1.05 -1.62 -0.55 1536.92 1.00 745 379 85 16 TRUE 3.93
colorectal cancer KRAS_12 BRAF Any mutation 661 250 TMB overall -2.62 -3.83 -1.54 1648.47 1.00 1158 650 239 11 TRUE 5.17
non-small cell lung cancer KRAS_12 BRAF Any mutation 830 171 TMB overall -1.41 -2.45 -0.48 1353.61 1.00 2076 808 149 22 TRUE 2.31
colorectal cancer KRAS_12 B2M Any mutation 216 50 TMB quintile 5 -0.51 -1.17 0.11 1506.54 1.00 355 203 37 13 FALSE 0.90
colorectal cancer KRAS_12 B2M Any mutation 23 79 TMB quintile 6 -0.21 -1.07 0.66 1417.97 1.00 76 13 69 10 FALSE 0.20
colorectal cancer KRAS_12 B2M Any mutation 239 129 TMB overall -0.34 -2.85 2.03 1382.78 1.00 431 216 106 23 FALSE 0.12
colorectal cancer KRAS_12 CARD11 Any mutation 271 28 TMB quintile 4 0.00 -0.79 0.73 1643.57 1.00 502 261 18 10 FALSE 0.00
colorectal cancer KRAS_12 CARD11 Any mutation 228 43 TMB quintile 5 -0.20 -0.86 0.41 1452.96 1.00 370 214 29 14 FALSE 0.27
colorectal cancer KRAS_12 CARD11 Any mutation 19 52 TMB quintile 6 0.29 -0.60 1.20 1621.35 1.00 90 11 44 8 FALSE 0.27
non-small cell lung cancer KRAS_12 CARD11 Any mutation 230 18 TMB quintile 4 0.16 -0.75 1.08 1484.57 1.00 521 223 11 7 FALSE 0.13
non-small cell lung cancer KRAS_12 CARD11 Any mutation 397 97 TMB quintile 5 -0.19 -0.64 0.29 1409.15 1.00 762 370 70 27 FALSE 0.39
colorectal cancer KRAS_12 CARD11 Any mutation 518 123 TMB overall 0.04 -1.32 1.47 1509.31 1.00 962 486 91 32 FALSE 0.02
non-small cell lung cancer KRAS_12 CARD11 Any mutation 627 115 TMB overall -0.01 -1.81 1.62 1387.39 1.00 1283 593 81 34 FALSE 0.00
non-small cell lung cancer KRAS_12 INPP4B Any mutation 230 17 TMB quintile 4 0.58 -0.28 1.44 1209.28 1.00 523 222 9 8 FALSE 0.73
non-small cell lung cancer KRAS_12 INPP4B Any mutation 398 87 TMB quintile 5 0.57 0.10 0.99 1502.11 1.00 785 360 49 38 FALSE 1.92
non-small cell lung cancer KRAS_12 INPP4B Any mutation 628 104 TMB overall 0.56 -0.84 2.05 1508.66 1.00 1308 582 58 46 FALSE 0.37
non-small cell lung cancer KRAS_12 NFE2L2 Any mutation 230 31 TMB quintile 4 -0.92 -1.73 -0.23 1434.00 1.00 512 225 26 5 FALSE 1.85
non-small cell lung cancer KRAS_12 NFE2L2 Any mutation 396 83 TMB quintile 5 -0.90 -1.43 -0.39 1529.20 1.00 765 382 69 14 FALSE 3.08
non-small cell lung cancer KRAS_12 NFE2L2 Any mutation 626 114 TMB overall -0.91 -1.90 0.04 1544.12 1.00 1277 607 95 19 FALSE 1.19
colorectal cancer KRAS_12 SOX9 Any mutation 144 17 TMB quintile 3 -0.06 -1.00 0.76 1637.89 1.00 331 139 12 5 FALSE 0.05
colorectal cancer KRAS_12 SOX9 Any mutation 275 85 TMB quintile 4 0.25 -0.23 0.68 1564.52 1.00 469 241 51 34 FALSE 0.53
colorectal cancer KRAS_12 SOX9 Any mutation 233 107 TMB quintile 5 0.12 -0.32 0.52 1519.70 1.00 339 192 66 41 FALSE 0.24
colorectal cancer KRAS_12 SOX9 Any mutation 19 50 TMB quintile 6 0.66 -0.14 1.52 1618.62 1.00 91 9 40 10 FALSE 0.90
colorectal cancer KRAS_12 SOX9 Any mutation 671 259 TMB overall 0.22 -0.78 1.27 1588.90 1.00 1230 581 169 90 FALSE 0.18
colorectal cancer KRAS_12 SMAD2 Any mutation 271 29 TMB quintile 4 0.38 -0.32 1.06 1711.09 1.00 505 258 16 13 TRUE 0.57
colorectal cancer KRAS_12 SMAD2 Any mutation 230 53 TMB quintile 5 0.56 0.04 1.11 1521.56 1.00 376 204 27 26 TRUE 1.40
colorectal cancer KRAS_12 SMAD2 Any mutation 18 16 TMB quintile 6 0.14 -1.10 1.22 1411.16 1.00 113 16 14 2 TRUE 0.09
colorectal cancer KRAS_12 SMAD2 Any mutation 519 98 TMB overall 0.38 -0.72 1.50 1412.80 1.00 994 478 57 41 TRUE 0.32
non-small cell lung cancer KRAS_12 GLI1 Any mutation 217 16 TMB quintile 4 0.53 -0.35 1.42 1545.61 1.00 457 209 8 8 FALSE 0.62
non-small cell lung cancer KRAS_12 GLI1 Any mutation 364 77 TMB quintile 5 0.27 -0.19 0.71 1442.02 1.00 695 335 48 29 FALSE 0.61
non-small cell lung cancer KRAS_12 GLI1 Any mutation 581 93 TMB overall 0.38 -1.01 1.79 1457.16 1.00 1152 544 56 37 FALSE 0.24
colorectal cancer KRAS_12 ZFHX3 Any mutation 248 14 TMB quintile 4 0.21 -0.85 1.20 1482.64 1.00 464 242 8 6 FALSE 0.16
colorectal cancer KRAS_12 ZFHX3 Any mutation 212 63 TMB quintile 5 -0.39 -0.95 0.15 1474.69 1.00 328 194 45 18 FALSE 0.78
colorectal cancer KRAS_12 ZFHX3 Any mutation 22 143 TMB quintile 6 0.77 -0.24 1.96 1614.66 1.00 47 3 124 19 FALSE 0.75
non-small cell lung cancer KRAS_12 ZFHX3 Any mutation 120 13 TMB quintile 3 -0.82 -2.23 0.24 1402.76 1.00 438 119 12 1 FALSE 0.72
non-small cell lung cancer KRAS_12 ZFHX3 Any mutation 216 30 TMB quintile 4 -0.34 -1.07 0.37 1593.74 1.00 441 208 22 8 FALSE 0.45
non-small cell lung cancer KRAS_12 ZFHX3 Any mutation 364 112 TMB quintile 5 -0.28 -0.73 0.14 1379.08 1.00 664 333 81 31 FALSE 0.65
uterine cancer KRAS_12 ZFHX3 Any mutation 36 13 TMB quintile 4 0.12 -1.27 1.47 1450.17 1.00 159 33 10 3 FALSE 0.06
uterine cancer KRAS_12 ZFHX3 Any mutation 49 105 TMB quintile 5 0.10 -0.52 0.69 1673.57 1.00 138 29 85 20 FALSE 0.13
colorectal cancer KRAS_12 ZFHX3 Any mutation 482 220 TMB overall 0.23 -1.90 2.54 1351.59 1.00 839 439 177 43 FALSE 0.07
non-small cell lung cancer KRAS_12 ZFHX3 Any mutation 700 155 TMB overall -0.47 -1.58 0.55 1296.38 1.00 1543 660 115 40 FALSE 0.44
uterine cancer KRAS_12 ZFHX3 Any mutation 89 210 TMB overall -0.03 -1.89 1.80 1544.08 1.00 321 63 184 26 FALSE 0.01
colorectal cancer KRAS_12 MGA Any mutation 248 15 TMB quintile 4 -1.32 -2.86 -0.08 1399.77 1.00 460 246 13 2 FALSE 1.24
colorectal cancer KRAS_12 MGA Any mutation 213 46 TMB quintile 5 -0.07 -0.72 0.55 1212.90 1.00 337 196 29 17 FALSE 0.08
colorectal cancer KRAS_12 MGA Any mutation 16 58 TMB quintile 6 -1.18 -2.57 -0.02 1396.44 1.00 75 13 55 3 FALSE 1.21
non-small cell lung cancer KRAS_12 MGA Any mutation 120 14 TMB quintile 3 0.15 -0.91 1.14 1350.48 1.00 441 116 10 4 FALSE 0.12
non-small cell lung cancer KRAS_12 MGA Any mutation 216 24 TMB quintile 4 0.01 -0.78 0.70 1216.58 1.00 447 208 16 8 FALSE 0.01
non-small cell lung cancer KRAS_12 MGA Any mutation 366 140 TMB quintile 5 0.00 -0.39 0.36 1344.58 1.00 659 321 95 45 FALSE 0.01
uterine cancer KRAS_12 MGA Any mutation 45 24 TMB quintile 5 -1.80 -4.03 -0.14 1369.22 1.00 183 44 23 1 FALSE 1.12
uterine cancer KRAS_12 MGA Any mutation 6 82 TMB quintile 6 0.12 -1.73 2.26 1448.61 1.00 23 1 77 5 FALSE 0.04
colorectal cancer KRAS_12 MGA Any mutation 477 119 TMB overall -0.86 -2.68 0.76 1460.29 1.00 872 455 97 22 FALSE 0.48
non-small cell lung cancer KRAS_12 MGA Any mutation 702 178 TMB overall 0.05 -0.96 1.13 1485.49 1.00 1547 645 121 57 FALSE 0.04
uterine cancer KRAS_12 MGA Any mutation 51 106 TMB overall -0.66 -3.91 2.95 1525.56 1.00 206 45 100 6 FALSE 0.16
colorectal cancer KRAS_12 KMT2B Any mutation 118 54 TMB quintile 5 -0.13 -0.76 0.45 1439.36 1.00 180 100 36 18 FALSE 0.16
colorectal cancer KRAS_12 KMT2B Any mutation 11 115 TMB quintile 6 0.52 -1.04 2.53 1467.76 1.00 21 1 105 10 FALSE 0.24
colorectal cancer KRAS_12 KMT2B Any mutation 129 169 TMB overall 0.11 -3.08 3.31 1501.50 1.00 201 101 141 28 FALSE 0.03
colorectal cancer KRAS_12 TCF7L2 Any mutation 130 35 TMB quintile 3 0.07 -0.63 0.75 1470.92 1.00 287 119 24 11 FALSE 0.08
colorectal cancer KRAS_12 TCF7L2 Any mutation 251 79 TMB quintile 4 0.37 -0.09 0.80 1380.79 1.00 428 217 45 34 FALSE 0.94
colorectal cancer KRAS_12 TCF7L2 Any mutation 216 108 TMB quintile 5 -0.01 -0.42 0.39 1374.56 1.01 302 177 69 39 FALSE 0.02
colorectal cancer KRAS_12 TCF7L2 Any mutation 18 70 TMB quintile 6 0.56 -0.34 1.49 1654.01 1.00 68 6 58 12 FALSE 0.67
colorectal cancer KRAS_12 TCF7L2 Any mutation 615 292 TMB overall 0.26 -0.60 1.28 1565.68 1.00 1085 519 196 96 FALSE 0.23
colorectal cancer KRAS_12 ANKRD11 Any mutation 241 11 TMB quintile 4 -0.18 -1.46 0.96 1483.38 1.00 454 237 7 4 FALSE 0.11
colorectal cancer KRAS_12 ANKRD11 Any mutation 197 43 TMB quintile 5 -1.33 -2.27 -0.53 1410.67 1.00 310 191 37 6 FALSE 2.63
colorectal cancer KRAS_12 ANKRD11 Any mutation 20 86 TMB quintile 6 -0.43 -1.37 0.44 1471.89 1.00 64 11 77 9 FALSE 0.45
colorectal cancer KRAS_12 ANKRD11 Any mutation 458 140 TMB overall -0.65 -2.69 1.34 1429.90 1.00 828 439 121 19 FALSE 0.29
colorectal cancer KRAS_12 POLD1 Any mutation 214 20 TMB quintile 5 -0.19 -1.11 0.67 1387.66 1.00 354 207 13 7 TRUE 0.16
colorectal cancer KRAS_12 POLD1 Any mutation 17 83 TMB quintile 6 -0.56 -1.64 0.41 1430.87 1.00 63 10 76 7 TRUE 0.54
colorectal cancer KRAS_12 POLD1 Any mutation 231 103 TMB overall -0.29 -3.29 2.78 1506.18 1.00 417 217 89 14 TRUE 0.07
non-small cell lung cancer KRAS_12 PREX2 Any mutation 119 14 TMB quintile 4 -0.12 -1.08 0.88 1512.57 1.00 231 114 9 5 FALSE 0.09
non-small cell lung cancer KRAS_12 PREX2 Any mutation 205 84 TMB quintile 5 -0.33 -0.84 0.17 1367.89 1.00 361 183 62 22 FALSE 0.69
non-small cell lung cancer KRAS_12 PREX2 Any mutation 324 98 TMB overall -0.25 -1.81 1.28 1439.60 1.00 592 297 71 27 FALSE 0.12
colorectal cancer KRAS_12 AMER1 Any mutation 144 13 TMB quintile 3 0.23 -0.81 1.20 1352.32 1.00 335 139 8 5 FALSE 0.18
colorectal cancer KRAS_12 AMER1 Any mutation 271 38 TMB quintile 4 0.80 0.15 1.40 1317.95 1.00 505 250 17 21 FALSE 1.91
colorectal cancer KRAS_12 AMER1 Any mutation 227 62 TMB quintile 5 0.34 -0.18 0.86 1529.01 1.00 364 200 35 27 FALSE 0.71
colorectal cancer KRAS_12 AMER1 Any mutation 18 55 TMB quintile 6 -0.30 -1.27 0.58 1290.78 1.00 85 13 50 5 FALSE 0.26
non-small cell lung cancer KRAS_12 AMER1 Any mutation 230 18 TMB quintile 4 1.19 0.25 2.21 1453.19 1.00 525 219 7 11 FALSE 1.82
non-small cell lung cancer KRAS_12 AMER1 Any mutation 398 107 TMB quintile 5 0.38 -0.04 0.77 1387.03 1.00 772 355 64 43 FALSE 1.20
colorectal cancer KRAS_12 AMER1 Any mutation 660 168 TMB overall 0.26 -0.97 1.35 1444.74 1.00 1289 602 110 58 FALSE 0.18
non-small cell lung cancer KRAS_12 AMER1 Any mutation 628 142 TMB overall 0.12 -3.45 3.37 1551.98 1.00 1307 574 88 54 FALSE 0.03
non-small cell lung cancer KRAS_12 EPHA7 Any mutation 216 14 TMB quintile 4 -0.04 -1.10 1.01 1518.38 1.00 453 211 9 5 FALSE 0.03
non-small cell lung cancer KRAS_12 EPHA7 Any mutation 363 101 TMB quintile 5 -0.29 -0.76 0.13 1542.52 1.00 673 336 74 27 FALSE 0.69
non-small cell lung cancer KRAS_12 EPHA7 Any mutation 579 115 TMB overall -0.16 -1.79 1.69 1527.52 1.00 1126 547 83 32 FALSE 0.07
non-small cell lung cancer RAS_12C SPEN Any mutation 42 15 TMB quintile 4 -2.17 -6.64 0.22 1467.47 1.00 705 42 15 0 FALSE 0.70
non-small cell lung cancer RAS_12C SPEN Any mutation 93 87 TMB quintile 5 -1.58 -3.39 -0.26 1525.58 1.00 1075 91 85 2 FALSE 1.33
non-small cell lung cancer RAS_12C SPEN Any mutation 135 102 TMB overall -1.79 -4.68 0.52 1446.55 1.00 1780 133 100 2 FALSE 0.76
non-small cell lung cancer RAS_12C KMT2C Any mutation 18 13 TMB quintile 3 -0.48 -2.73 1.18 1472.07 1.00 591 18 13 0 FALSE 0.20
non-small cell lung cancer RAS_12C KMT2C Any mutation 42 36 TMB quintile 4 0.18 -1.07 1.21 1520.50 1.00 686 39 33 3 FALSE 0.12
non-small cell lung cancer RAS_12C KMT2C Any mutation 94 155 TMB quintile 5 -0.09 -0.76 0.53 1411.57 1.00 992 83 144 11 FALSE 0.11
non-small cell lung cancer RAS_12C KMT2C Any mutation 154 204 TMB overall -0.13 -1.62 1.22 1494.97 1.00 2269 140 190 14 FALSE 0.07
non-small cell lung cancer RAS_12C TP53 Any mutation 13 180 TMB quintile 2 -0.96 -1.95 0.02 1490.55 1.00 254 9 176 4 TRUE 1.24
non-small cell lung cancer RAS_12C TP53 Any mutation 18 324 TMB quintile 3 -1.77 -2.84 -0.88 1325.65 1.00 299 16 322 2 TRUE 3.30
non-small cell lung cancer RAS_12C TP53 Any mutation 42 450 TMB quintile 4 -1.36 -2.03 -0.72 1484.38 1.00 307 31 439 11 TRUE 4.44
non-small cell lung cancer RAS_12C TP53 Any mutation 97 996 TMB quintile 5 -1.03 -1.42 -0.64 1686.06 1.00 287 45 944 52 TRUE 6.30
non-small cell lung cancer RAS_12C TP53 Any mutation 170 1950 TMB overall -1.28 -2.11 -0.45 1553.32 1.00 1147 101 1881 69 TRUE 2.53
non-small cell lung cancer RAS_12C ATRX Any mutation 42 32 TMB quintile 4 -0.15 -1.44 1.00 1599.22 1.00 691 40 30 2 TRUE 0.09
non-small cell lung cancer RAS_12C ATRX Any mutation 94 160 TMB quintile 5 -0.36 -1.06 0.27 1427.92 1.00 1004 85 151 9 TRUE 0.55
non-small cell lung cancer RAS_12C ATRX Any mutation 136 192 TMB overall -0.22 -1.91 1.42 1401.00 1.00 1695 125 181 11 TRUE 0.10
non-small cell lung cancer RAS_12C ATR Any mutation 18 12 TMB quintile 3 0.18 -1.76 1.75 1492.52 1.00 597 17 11 1 FALSE 0.07
non-small cell lung cancer RAS_12C ATR Any mutation 42 15 TMB quintile 4 -0.63 -3.04 0.93 1456.77 1.00 707 42 15 0 FALSE 0.28
non-small cell lung cancer RAS_12C ATR Any mutation 93 93 TMB quintile 5 0.09 -0.70 0.84 1576.66 1.00 1047 85 85 8 FALSE 0.09
non-small cell lung cancer RAS_12C ATR Any mutation 153 120 TMB overall -0.12 -1.69 1.21 1436.64 1.00 2351 144 111 9 FALSE 0.06
non-small cell lung cancer RAS_12C PDGFRA Any mutation 42 16 TMB quintile 4 0.69 -0.74 1.87 1410.97 1.00 706 40 14 2 TRUE 0.51
non-small cell lung cancer RAS_12C PDGFRA Any mutation 95 115 TMB quintile 5 0.56 -0.06 1.14 1518.78 1.00 1034 81 101 14 TRUE 1.16
non-small cell lung cancer RAS_12C PDGFRA Any mutation 137 131 TMB overall 0.56 -1.36 2.39 1445.57 1.00 1740 121 115 16 TRUE 0.24
non-small cell lung cancer RAS_12C FLT4 Any mutation 42 14 TMB quintile 4 -0.13 -1.97 1.47 1567.40 1.00 707 41 13 1 TRUE 0.05
non-small cell lung cancer RAS_12C FLT4 Any mutation 93 74 TMB quintile 5 -0.17 -1.13 0.67 1538.83 1.00 1065 88 69 5 TRUE 0.14
non-small cell lung cancer RAS_12C FLT4 Any mutation 135 88 TMB overall -0.12 -1.93 1.80 1584.67 1.00 1772 129 82 6 TRUE 0.05
non-small cell lung cancer RAS_12C PTPRD Any mutation 18 16 TMB quintile 3 -1.52 -5.75 1.02 1464.57 1.00 593 18 16 0 FALSE 0.42
non-small cell lung cancer RAS_12C PTPRD Any mutation 42 53 TMB quintile 4 -0.65 -2.39 0.65 1318.31 1.00 670 40 51 2 FALSE 0.40
non-small cell lung cancer RAS_12C PTPRD Any mutation 98 298 TMB quintile 5 0.16 -0.30 0.63 1611.07 1.00 904 72 272 26 FALSE 0.30
non-small cell lung cancer RAS_12C PTPRD Any mutation 158 384 TMB overall -0.83 -3.47 1.10 1628.15 1.00 2174 130 356 28 FALSE 0.33
non-small cell lung cancer RAS_12C PIK3C2G Any mutation 42 12 TMB quintile 4 -0.23 -2.43 1.54 1559.36 1.00 706 41 11 1 FALSE 0.09
non-small cell lung cancer RAS_12C PIK3C2G Any mutation 94 103 TMB quintile 5 -0.58 -1.56 0.23 1311.54 1.00 1033 89 98 5 FALSE 0.66
non-small cell lung cancer RAS_12C PIK3C2G Any mutation 136 115 TMB overall -0.37 -2.62 1.85 1517.34 1.00 1739 130 109 6 FALSE 0.13
non-small cell lung cancer RAS_12C CREBBP Any mutation 18 11 TMB quintile 3 -0.92 -3.68 1.37 1451.81 1.00 597 18 11 0 TRUE 0.30
non-small cell lung cancer RAS_12C CREBBP Any mutation 42 12 TMB quintile 4 0.32 -1.52 1.96 1649.20 1.00 710 40 10 2 TRUE 0.14
non-small cell lung cancer RAS_12C CREBBP Any mutation 93 106 TMB quintile 5 -1.01 -2.19 -0.05 1565.87 1.00 1036 90 103 3 TRUE 1.20
non-small cell lung cancer RAS_12C CREBBP Any mutation 153 129 TMB overall -0.49 -2.41 1.37 1522.11 1.00 2343 148 124 5 TRUE 0.22
non-small cell lung cancer RAS_12C DOT1L Any mutation 42 24 TMB quintile 4 -0.73 -2.51 0.67 1027.46 1.00 699 41 23 1 FALSE 0.43
non-small cell lung cancer RAS_12C DOT1L Any mutation 93 75 TMB quintile 5 -0.80 -2.10 0.21 1498.20 1.00 1059 90 72 3 FALSE 0.75
non-small cell lung cancer RAS_12C DOT1L Any mutation 135 99 TMB overall -0.78 -2.37 0.66 1793.95 1.00 1758 131 95 4 FALSE 0.47
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 18 35 TMB quintile 3 0.44 -0.78 1.65 1473.55 1.00 579 16 33 2 FALSE 0.32
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 43 67 TMB quintile 4 1.03 0.23 1.81 1530.21 1.00 666 33 57 10 FALSE 2.15
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 95 194 TMB quintile 5 -0.34 -1.04 0.26 1318.60 1.00 955 85 184 10 FALSE 0.53
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 156 296 TMB overall 0.39 -0.78 1.67 1540.84 1.00 2200 134 274 22 FALSE 0.28
non-small cell lung cancer RAS_12C PTPRT Any mutation 18 17 TMB quintile 3 0.91 -1.01 2.38 1532.23 1.00 593 16 15 2 FALSE 0.51
non-small cell lung cancer RAS_12C PTPRT Any mutation 42 38 TMB quintile 4 -1.04 -3.29 0.57 1522.39 1.00 684 41 37 1 FALSE 0.53
non-small cell lung cancer RAS_12C PTPRT Any mutation 94 272 TMB quintile 5 -1.03 -1.80 -0.37 1415.53 1.00 918 85 263 9 FALSE 2.29
non-small cell lung cancer RAS_12C PTPRT Any mutation 154 348 TMB overall -0.59 -2.86 1.62 1385.74 1.00 2200 142 336 12 FALSE 0.23
non-small cell lung cancer RAS_12C HGF Any mutation 42 27 TMB quintile 4 -0.03 -1.86 1.36 1357.31 1.00 696 40 25 2 FALSE 0.01
non-small cell lung cancer RAS_12C HGF Any mutation 94 138 TMB quintile 5 -0.39 -1.18 0.30 1597.53 1.00 1006 86 130 8 FALSE 0.50
non-small cell lung cancer RAS_12C HGF Any mutation 136 180 TMB overall -0.51 -3.31 2.06 1478.89 1.00 1709 126 170 10 FALSE 0.16
non-small cell lung cancer RAS_12C PIK3CA Any mutation 13 18 TMB quintile 2 0.07 -1.09 1.20 1314.03 1.00 411 12 17 1 TRUE 0.04
non-small cell lung cancer RAS_12C PIK3CA Any mutation 18 34 TMB quintile 3 0.21 -0.86 1.28 1470.28 1.00 576 16 32 2 TRUE 0.16
non-small cell lung cancer RAS_12C PIK3CA Any mutation 43 56 TMB quintile 4 -0.16 -1.21 0.66 1526.98 1.00 666 41 54 2 TRUE 0.13
non-small cell lung cancer RAS_12C PIK3CA Any mutation 93 123 TMB quintile 5 0.09 -0.55 0.69 1398.69 1.00 1026 83 113 10 TRUE 0.10
non-small cell lung cancer RAS_12C PIK3CA Any mutation 167 231 TMB overall 0.04 -0.82 0.84 1325.41 1.00 2679 152 216 15 TRUE 0.03
non-small cell lung cancer RAS_12C ALK Any mutation 18 13 TMB quintile 3 -1.93 -6.71 0.88 1474.68 1.00 596 18 13 0 TRUE 0.49
non-small cell lung cancer RAS_12C ALK Any mutation 42 22 TMB quintile 4 -2.28 -6.57 0.27 1258.60 1.00 699 42 22 0 TRUE 0.66
non-small cell lung cancer RAS_12C ALK Any mutation 93 118 TMB quintile 5 0.26 -0.43 0.85 1406.04 1.00 1030 81 106 12 TRUE 0.36
non-small cell lung cancer RAS_12C ALK Any mutation 153 164 TMB overall -1.37 -4.27 0.89 1427.07 1.00 2334 141 152 12 TRUE 0.53
non-small cell lung cancer RAS_12C PTEN Any mutation 18 17 TMB quintile 3 -5.56 -12.21 -1.34 979.98 1.00 591 18 17 0 TRUE 1.29
non-small cell lung cancer RAS_12C PTEN Any mutation 42 27 TMB quintile 4 -5.60 -12.08 -1.56 1029.91 1.00 694 42 27 0 TRUE 1.31
non-small cell lung cancer RAS_12C PTEN Any mutation 93 75 TMB quintile 5 -5.65 -12.04 -1.83 1079.35 1.00 1061 93 75 0 TRUE 1.38
non-small cell lung cancer RAS_12C PTEN Any mutation 153 119 TMB overall -5.55 -11.86 -1.63 1019.86 1.00 2346 153 119 0 TRUE 1.34
non-small cell lung cancer RAS_12C BCOR Any mutation 42 22 TMB quintile 4 -0.26 -2.17 0.99 1251.80 1.00 700 41 21 1 FALSE 0.13
non-small cell lung cancer RAS_12C BCOR Any mutation 95 92 TMB quintile 5 0.07 -0.72 0.75 1483.10 1.00 1052 87 84 8 FALSE 0.07
non-small cell lung cancer RAS_12C BCOR Any mutation 137 114 TMB overall -0.10 -1.87 1.38 1396.11 1.00 1752 128 105 9 FALSE 0.04
non-small cell lung cancer RAS_12C CTNNB1 Any mutation 13 12 TMB quintile 2 -0.28 -1.59 0.87 1611.22 1.00 417 12 11 1 TRUE 0.18
non-small cell lung cancer RAS_12C CTNNB1 Any mutation 18 22 TMB quintile 3 -0.50 -1.86 0.66 1358.58 1.00 586 18 22 0 TRUE 0.35
non-small cell lung cancer RAS_12C CTNNB1 Any mutation 42 33 TMB quintile 4 -0.45 -1.78 0.64 1594.46 1.00 691 41 32 1 TRUE 0.34
non-small cell lung cancer RAS_12C CTNNB1 Any mutation 93 47 TMB quintile 5 -0.35 -1.40 0.56 1378.86 1.00 1086 90 44 3 TRUE 0.30
non-small cell lung cancer RAS_12C CTNNB1 Any mutation 166 114 TMB overall -0.39 -1.52 0.58 1419.86 1.00 2780 161 109 5 TRUE 0.33
non-small cell lung cancer RAS_12C ARID1A Any mutation 18 12 TMB quintile 3 0.11 -1.77 1.83 1520.38 1.00 597 17 11 1 TRUE 0.04
non-small cell lung cancer RAS_12C ARID1A Any mutation 42 56 TMB quintile 4 -0.88 -2.55 0.42 1474.24 1.00 668 41 55 1 TRUE 0.62
non-small cell lung cancer RAS_12C ARID1A Any mutation 95 187 TMB quintile 5 -0.07 -0.70 0.49 1583.19 1.00 975 81 173 14 TRUE 0.09
non-small cell lung cancer RAS_12C ARID1A Any mutation 155 255 TMB overall -0.27 -1.76 1.19 1598.57 1.00 2240 139 239 16 TRUE 0.14
non-small cell lung cancer RAS_12C FAT1 Any mutation 18 16 TMB quintile 3 -0.08 -2.51 1.85 1495.15 1.00 593 17 15 1 FALSE 0.02
non-small cell lung cancer RAS_12C FAT1 Any mutation 42 43 TMB quintile 4 -1.11 -3.02 0.46 1327.55 1.00 683 41 42 1 FALSE 0.66
non-small cell lung cancer RAS_12C FAT1 Any mutation 93 227 TMB quintile 5 -0.68 -1.40 -0.04 1392.99 1.00 936 83 217 10 FALSE 1.35
non-small cell lung cancer RAS_12C FAT1 Any mutation 153 300 TMB overall -0.72 -2.87 1.21 1484.66 1.00 2219 141 288 12 FALSE 0.32
non-small cell lung cancer RAS_12C NCOR1 Any mutation 42 21 TMB quintile 4 0.05 -1.33 1.29 1354.81 1.00 702 40 19 2 FALSE 0.03
non-small cell lung cancer RAS_12C NCOR1 Any mutation 93 71 TMB quintile 5 -0.27 -1.32 0.62 1480.79 1.00 1072 89 67 4 FALSE 0.23
non-small cell lung cancer RAS_12C NCOR1 Any mutation 135 92 TMB overall -0.09 -1.61 1.41 1542.20 1.00 1774 129 86 6 FALSE 0.04
non-small cell lung cancer RAS_12C POLE Any mutation 42 20 TMB quintile 4 0.44 -0.83 1.63 1318.09 1.00 702 40 18 2 TRUE 0.31
non-small cell lung cancer RAS_12C POLE Any mutation 93 102 TMB quintile 5 0.42 -0.25 1.00 1338.45 1.00 1046 82 91 11 TRUE 0.72
non-small cell lung cancer RAS_12C POLE Any mutation 135 122 TMB overall 0.39 -1.26 1.83 1263.12 1.00 1748 122 109 13 TRUE 0.21
non-small cell lung cancer RAS_12C NOTCH2 Any mutation 42 16 TMB quintile 4 -0.42 -2.34 1.13 1385.66 1.00 703 41 15 1 TRUE 0.20
non-small cell lung cancer RAS_12C NOTCH2 Any mutation 93 81 TMB quintile 5 -0.54 -1.59 0.39 1248.53 1.00 1055 89 77 4 TRUE 0.54
non-small cell lung cancer RAS_12C NOTCH2 Any mutation 135 97 TMB overall -0.45 -2.55 1.41 1395.53 1.00 1758 130 92 5 TRUE 0.19
non-small cell lung cancer RAS_12C KMT2A Any mutation 42 16 TMB quintile 4 -1.35 -5.49 0.72 1391.55 1.00 704 42 16 0 FALSE 0.40
non-small cell lung cancer RAS_12C KMT2A Any mutation 93 80 TMB quintile 5 -0.38 -1.40 0.54 1521.52 1.00 1060 88 75 5 FALSE 0.35
non-small cell lung cancer RAS_12C KMT2A Any mutation 135 96 TMB overall -0.80 -3.53 1.30 1466.95 1.00 1764 130 91 5 FALSE 0.30
non-small cell lung cancer RAS_12C PAK7 Any mutation 42 13 TMB quintile 4 -1.47 -5.36 0.79 1514.02 1.00 704 42 13 0 FALSE 0.43
non-small cell lung cancer RAS_12C PAK7 Any mutation 93 95 TMB quintile 5 -0.57 -1.66 0.33 1471.56 1.00 1043 88 90 5 FALSE 0.58
non-small cell lung cancer RAS_12C PAK7 Any mutation 135 108 TMB overall -0.96 -3.84 1.26 1346.37 1.00 1747 130 103 5 FALSE 0.35
non-small cell lung cancer RAS_12C STAG2 Any mutation 42 19 TMB quintile 4 -1.48 -5.22 0.47 1331.09 1.00 701 42 19 0 TRUE 0.49
non-small cell lung cancer RAS_12C STAG2 Any mutation 93 76 TMB quintile 5 -0.66 -2.00 0.44 1368.04 1.00 1064 89 72 4 TRUE 0.57
non-small cell lung cancer RAS_12C STAG2 Any mutation 135 95 TMB overall -1.01 -3.44 0.83 1264.60 1.00 1765 131 91 4 TRUE 0.43
non-small cell lung cancer RAS_12C TERT Any mutation 18 13 TMB quintile 3 0.45 -1.04 1.79 1532.04 1.00 597 17 12 1 TRUE 0.26
non-small cell lung cancer RAS_12C TERT Any mutation 42 34 TMB quintile 4 0.40 -0.76 1.37 1387.77 1.00 690 39 31 3 TRUE 0.33
non-small cell lung cancer RAS_12C TERT Any mutation 94 98 TMB quintile 5 0.25 -0.49 0.90 1590.28 1.00 1047 85 89 9 TRUE 0.32
non-small cell lung cancer RAS_12C TERT Any mutation 154 145 TMB overall 0.37 -0.79 1.58 1583.44 1.00 2334 141 132 13 TRUE 0.28
non-small cell lung cancer RAS_12C BRCA2 Any mutation 42 23 TMB quintile 4 0.02 -1.87 1.41 1552.28 1.00 700 40 21 2 TRUE 0.01
non-small cell lung cancer RAS_12C BRCA2 Any mutation 93 89 TMB quintile 5 -1.01 -2.34 0.04 1259.59 1.00 1049 90 86 3 TRUE 1.01
non-small cell lung cancer RAS_12C BRCA2 Any mutation 135 126 TMB overall -0.74 -3.56 1.90 1568.45 1.00 1758 130 121 5 TRUE 0.23
non-small cell lung cancer RAS_12C NOTCH3 Any mutation 42 21 TMB quintile 4 0.30 -1.33 1.65 1520.56 1.00 702 40 19 2 TRUE 0.16
non-small cell lung cancer RAS_12C NOTCH3 Any mutation 93 82 TMB quintile 5 0.07 -0.79 0.84 1417.83 1.00 1060 86 75 7 TRUE 0.07
non-small cell lung cancer RAS_12C NOTCH3 Any mutation 135 114 TMB overall -0.14 -2.79 2.24 1267.24 1.00 1771 126 105 9 TRUE 0.04
non-small cell lung cancer RAS_12C NOTCH4 Any mutation 42 17 TMB quintile 4 -1.66 -5.60 0.55 1380.53 1.00 700 42 17 0 TRUE 0.50
non-small cell lung cancer RAS_12C NOTCH4 Any mutation 93 107 TMB quintile 5 -0.49 -1.42 0.33 1545.10 1.00 1028 87 101 6 TRUE 0.56
non-small cell lung cancer RAS_12C NOTCH4 Any mutation 135 124 TMB overall -1.00 -3.77 1.14 1642.40 1.00 1728 129 118 6 TRUE 0.37
non-small cell lung cancer RAS_12C KEAP1 Any mutation 13 12 TMB quintile 2 -0.09 -2.11 1.62 1354.90 1.00 416 13 12 0 FALSE 0.03
non-small cell lung cancer RAS_12C KEAP1 Any mutation 18 50 TMB quintile 3 0.90 -0.24 1.93 1456.95 1.00 562 14 46 4 FALSE 0.98
non-small cell lung cancer RAS_12C KEAP1 Any mutation 43 129 TMB quintile 4 0.86 0.23 1.49 1423.57 1.00 608 29 115 14 FALSE 2.07
non-small cell lung cancer RAS_12C KEAP1 Any mutation 95 336 TMB quintile 5 -0.11 -0.58 0.36 1471.08 1.00 833 72 313 23 FALSE 0.18
non-small cell lung cancer RAS_12C KEAP1 Any mutation 169 527 TMB overall 0.39 -0.84 1.47 1381.53 1.00 2419 128 486 41 FALSE 0.30
non-small cell lung cancer RAS_12C KDM5C Any mutation 42 16 TMB quintile 4 -0.95 -5.54 0.94 1206.24 1.00 704 42 16 0 FALSE 0.24
non-small cell lung cancer RAS_12C KDM5C Any mutation 94 70 TMB quintile 5 0.33 -0.49 1.12 1481.56 1.00 1072 86 62 8 FALSE 0.38
non-small cell lung cancer RAS_12C KDM5C Any mutation 136 86 TMB overall -0.29 -3.11 1.61 1200.16 1.00 1776 128 78 8 FALSE 0.09
non-small cell lung cancer RAS_12C CDKN2A Any mutation 18 33 TMB quintile 3 -1.21 -3.28 0.33 1336.07 1.00 576 18 33 0 TRUE 0.70
non-small cell lung cancer RAS_12C CDKN2A Any mutation 42 43 TMB quintile 4 -0.96 -2.56 0.36 1305.09 1.00 679 41 42 1 TRUE 0.74
non-small cell lung cancer RAS_12C CDKN2A Any mutation 95 178 TMB quintile 5 -0.60 -1.34 0.05 1372.64 1.00 975 86 169 9 TRUE 1.05
non-small cell lung cancer RAS_12C CDKN2A Any mutation 155 254 TMB overall -0.92 -2.45 0.33 1491.67 1.00 2230 145 244 10 TRUE 0.73
non-small cell lung cancer RAS_12C EPHB1 Any mutation 42 19 TMB quintile 4 -2.82 -8.11 0.32 1415.72 1.00 701 42 19 0 FALSE 0.70
non-small cell lung cancer RAS_12C EPHB1 Any mutation 93 117 TMB quintile 5 -0.83 -1.93 0.06 1221.42 1.01 1024 88 112 5 FALSE 0.98
non-small cell lung cancer RAS_12C EPHB1 Any mutation 135 152 TMB overall -1.79 -5.58 1.17 1541.32 1.00 1734 130 147 5 FALSE 0.56
non-small cell lung cancer RAS_12C SMAD4 Any mutation 18 21 TMB quintile 3 -0.02 -1.43 1.26 1563.00 1.00 588 17 20 1 TRUE 0.01
non-small cell lung cancer RAS_12C SMAD4 Any mutation 42 36 TMB quintile 4 -0.55 -2.62 0.72 1467.31 1.00 688 42 36 0 TRUE 0.29
non-small cell lung cancer RAS_12C SMAD4 Any mutation 93 49 TMB quintile 5 0.23 -0.65 1.09 1506.97 1.00 1087 87 43 6 TRUE 0.22
non-small cell lung cancer RAS_12C SMAD4 Any mutation 153 106 TMB overall -0.12 -1.49 0.92 1470.90 1.00 2363 146 99 7 TRUE 0.07
non-small cell lung cancer RAS_12C ATM Any mutation 13 15 TMB quintile 2 0.19 -1.57 1.52 1464.73 1.00 414 13 15 0 TRUE 0.09
non-small cell lung cancer RAS_12C ATM Any mutation 18 20 TMB quintile 3 0.50 -0.86 1.76 1547.10 1.00 589 17 19 1 TRUE 0.35
non-small cell lung cancer RAS_12C ATM Any mutation 43 76 TMB quintile 4 0.61 -0.20 1.33 1425.64 1.00 661 36 69 7 TRUE 0.89
non-small cell lung cancer RAS_12C ATM Any mutation 99 166 TMB quintile 5 0.86 0.35 1.31 1621.54 1.00 1003 74 141 25 TRUE 3.25
non-small cell lung cancer RAS_12C ATM Any mutation 173 277 TMB overall 0.52 -0.52 1.45 1384.59 1.00 2667 140 244 33 TRUE 0.55
non-small cell lung cancer RAS_12C RB1 Any mutation 18 33 TMB quintile 3 -0.90 -2.45 0.54 1447.01 1.00 576 17 32 1 TRUE 0.65
non-small cell lung cancer RAS_12C RB1 Any mutation 42 50 TMB quintile 4 -1.36 -3.07 -0.14 1431.52 1.00 670 42 50 0 TRUE 1.09
non-small cell lung cancer RAS_12C RB1 Any mutation 93 124 TMB quintile 5 -0.89 -1.86 -0.06 1319.49 1.00 1016 88 119 5 TRUE 1.26
non-small cell lung cancer RAS_12C RB1 Any mutation 153 207 TMB overall -1.04 -2.36 0.10 1351.78 1.00 2262 147 201 6 TRUE 1.00
non-small cell lung cancer RAS_12C KMT2D Any mutation 18 15 TMB quintile 3 -1.66 -5.17 0.89 1515.75 1.00 593 18 15 0 FALSE 0.55
non-small cell lung cancer RAS_12C KMT2D Any mutation 42 42 TMB quintile 4 -1.20 -3.26 0.43 1473.45 1.00 682 41 41 1 FALSE 0.68
non-small cell lung cancer RAS_12C KMT2D Any mutation 94 251 TMB quintile 5 -0.62 -1.27 -0.02 1529.91 1.00 931 82 239 12 FALSE 1.26
non-small cell lung cancer RAS_12C KMT2D Any mutation 154 320 TMB overall -1.23 -3.71 0.82 1487.65 1.00 2214 141 307 13 FALSE 0.59
non-small cell lung cancer RAS_12C APC Any mutation 18 20 TMB quintile 3 -1.00 -3.83 0.81 1510.10 1.00 588 18 20 0 TRUE 0.39
non-small cell lung cancer RAS_12C APC Any mutation 42 31 TMB quintile 4 -1.18 -4.20 0.40 1322.18 1.00 689 42 31 0 TRUE 0.52
non-small cell lung cancer RAS_12C APC Any mutation 96 101 TMB quintile 5 -0.03 -0.80 0.69 1432.04 1.00 1044 87 92 9 TRUE 0.03
non-small cell lung cancer RAS_12C APC Any mutation 156 152 TMB overall -0.73 -3.02 0.63 1477.06 1.00 2321 147 143 9 TRUE 0.38
non-small cell lung cancer RAS_12C ERBB2 Any mutation 13 14 TMB quintile 2 -5.53 -12.07 -1.42 1287.96 1.00 414 13 14 0 TRUE 1.30
non-small cell lung cancer RAS_12C ERBB2 Any mutation 18 27 TMB quintile 3 -5.53 -12.25 -1.53 1308.00 1.00 581 18 27 0 TRUE 1.30
non-small cell lung cancer RAS_12C ERBB2 Any mutation 42 32 TMB quintile 4 -5.53 -12.25 -1.52 1251.21 1.00 690 42 32 0 TRUE 1.30
non-small cell lung cancer RAS_12C ERBB2 Any mutation 93 40 TMB quintile 5 -5.53 -12.06 -1.53 1256.05 1.00 1093 93 40 0 TRUE 1.31
non-small cell lung cancer RAS_12C ERBB2 Any mutation 166 113 TMB overall -5.53 -12.04 -1.55 1268.25 1.00 2778 166 113 0 TRUE 1.32
non-small cell lung cancer RAS_12C ARID2 Any mutation 18 19 TMB quintile 3 -0.47 -2.43 1.00 1414.82 1.00 589 18 19 0 FALSE 0.23
non-small cell lung cancer RAS_12C ARID2 Any mutation 42 35 TMB quintile 4 -0.14 -1.50 0.92 1467.96 1.00 689 40 33 2 FALSE 0.09
non-small cell lung cancer RAS_12C ARID2 Any mutation 94 111 TMB quintile 5 0.01 -0.73 0.69 1528.66 1.00 1038 85 102 9 FALSE 0.01
non-small cell lung cancer RAS_12C ARID2 Any mutation 154 165 TMB overall -0.20 -1.55 0.95 1348.15 1.00 2316 143 154 11 FALSE 0.13
non-small cell lung cancer RAS_12C MTOR Any mutation 18 14 TMB quintile 3 -0.07 -2.11 1.39 1450.61 1.00 594 18 14 0 TRUE 0.03
non-small cell lung cancer RAS_12C MTOR Any mutation 42 21 TMB quintile 4 0.05 -1.57 1.23 1572.66 1.00 701 41 20 1 TRUE 0.02
non-small cell lung cancer RAS_12C MTOR Any mutation 95 70 TMB quintile 5 0.60 -0.12 1.23 1519.89 1.00 1070 85 60 10 TRUE 1.05
non-small cell lung cancer RAS_12C MTOR Any mutation 155 105 TMB overall 0.22 -1.23 1.34 1648.58 1.00 2365 144 94 11 TRUE 0.13
non-small cell lung cancer RAS_12C NOTCH1 Any mutation 42 15 TMB quintile 4 -0.21 -2.05 1.36 1410.88 1.00 706 41 14 1 TRUE 0.09
non-small cell lung cancer RAS_12C NOTCH1 Any mutation 94 97 TMB quintile 5 -0.29 -1.23 0.48 1557.11 1.00 1044 88 91 6 TRUE 0.29
non-small cell lung cancer RAS_12C NOTCH1 Any mutation 136 112 TMB overall -0.22 -2.25 1.73 1521.52 1.00 1750 129 105 7 TRUE 0.08
non-small cell lung cancer RAS_12C SETD2 Any mutation 13 14 TMB quintile 2 -0.69 -2.79 0.82 1386.93 1.00 414 13 14 0 FALSE 0.34
non-small cell lung cancer RAS_12C SETD2 Any mutation 18 22 TMB quintile 3 -0.73 -2.92 0.73 1216.45 1.00 592 18 22 0 FALSE 0.36
non-small cell lung cancer RAS_12C SETD2 Any mutation 42 59 TMB quintile 4 -0.80 -2.39 0.34 1500.35 1.00 671 41 58 1 FALSE 0.63
non-small cell lung cancer RAS_12C SETD2 Any mutation 96 110 TMB quintile 5 0.11 -0.59 0.77 1016.19 1.01 1044 85 99 11 FALSE 0.12
non-small cell lung cancer RAS_12C SETD2 Any mutation 169 205 TMB overall -0.54 -2.03 0.55 1375.92 1.00 2721 157 193 12 FALSE 0.38
non-small cell lung cancer RAS_12C PBRM1 Any mutation 42 21 TMB quintile 4 -0.24 -1.73 1.04 1290.95 1.00 703 41 20 1 TRUE 0.13
non-small cell lung cancer RAS_12C PBRM1 Any mutation 93 79 TMB quintile 5 -0.07 -0.98 0.70 1452.79 1.00 1066 87 73 6 TRUE 0.06
non-small cell lung cancer RAS_12C PBRM1 Any mutation 135 100 TMB overall -0.15 -1.64 1.33 1626.45 1.00 1769 128 93 7 TRUE 0.07
non-small cell lung cancer RAS_12C EPHA3 Any mutation 18 15 TMB quintile 3 -1.34 -4.91 1.15 1489.46 1.00 593 18 15 0 FALSE 0.42
non-small cell lung cancer RAS_12C EPHA3 Any mutation 42 28 TMB quintile 4 -0.14 -1.80 1.22 1533.77 1.00 694 40 26 2 FALSE 0.07
non-small cell lung cancer RAS_12C EPHA3 Any mutation 94 182 TMB quintile 5 -0.33 -1.07 0.29 1522.34 1.00 976 83 171 11 FALSE 0.48
non-small cell lung cancer RAS_12C EPHA3 Any mutation 154 237 TMB overall -0.73 -2.99 1.22 1531.56 1.00 2271 141 224 13 FALSE 0.30
non-small cell lung cancer RAS_12C KDR Any mutation 42 21 TMB quintile 4 0.64 -0.62 1.88 1502.75 1.00 702 39 18 3 TRUE 0.50
non-small cell lung cancer RAS_12C KDR Any mutation 95 109 TMB quintile 5 -0.01 -0.81 0.69 1488.12 1.00 1032 87 101 8 TRUE 0.01
non-small cell lung cancer RAS_12C KDR Any mutation 137 130 TMB overall 0.31 -1.53 2.00 1488.99 1.00 1734 126 119 11 TRUE 0.13
non-small cell lung cancer RAS_12C TET1 Any mutation 42 16 TMB quintile 4 -3.03 -9.55 0.37 1510.15 1.00 701 42 16 0 FALSE 0.61
non-small cell lung cancer RAS_12C TET1 Any mutation 93 89 TMB quintile 5 -0.27 -1.28 0.51 1573.59 1.00 1051 87 83 6 FALSE 0.25
non-small cell lung cancer RAS_12C TET1 Any mutation 135 120 TMB overall -1.63 -5.74 1.56 1504.82 1.00 1757 129 114 6 FALSE 0.44
non-small cell lung cancer RAS_12C TBX3 Any mutation 42 11 TMB quintile 4 0.73 -1.12 2.35 1705.74 1.00 711 40 9 2 FALSE 0.39
non-small cell lung cancer RAS_12C TBX3 Any mutation 93 108 TMB quintile 5 -0.52 -1.47 0.28 1336.17 1.00 1035 88 103 5 FALSE 0.60
non-small cell lung cancer RAS_12C TBX3 Any mutation 135 119 TMB overall 0.16 -2.08 2.64 1536.45 1.00 1746 128 112 7 FALSE 0.05
non-small cell lung cancer RAS_12C NTRK3 Any mutation 42 31 TMB quintile 4 0.81 -0.42 1.80 1494.67 1.00 696 38 27 4 FALSE 0.80
non-small cell lung cancer RAS_12C NTRK3 Any mutation 93 144 TMB quintile 5 0.30 -0.33 0.88 1451.32 1.00 1013 79 130 14 FALSE 0.50
non-small cell lung cancer RAS_12C NTRK3 Any mutation 135 195 TMB overall 0.13 -2.77 2.88 1376.06 1.00 1716 117 177 18 FALSE 0.04
non-small cell lung cancer RAS_12C GRIN2A Any mutation 18 17 TMB quintile 3 1.14 -0.25 2.60 1493.38 1.00 594 15 14 3 FALSE 0.90
non-small cell lung cancer RAS_12C GRIN2A Any mutation 42 39 TMB quintile 4 -0.26 -1.76 0.86 1404.73 1.00 683 41 38 1 FALSE 0.15
non-small cell lung cancer RAS_12C GRIN2A Any mutation 94 124 TMB quintile 5 0.21 -0.40 0.77 1392.57 1.00 1025 83 113 11 FALSE 0.30
non-small cell lung cancer RAS_12C GRIN2A Any mutation 154 180 TMB overall 0.34 -0.97 1.62 1293.85 1.00 2302 139 165 15 FALSE 0.21
non-small cell lung cancer RAS_12C STK11 Any mutation 13 12 TMB quintile 2 0.78 -0.90 2.29 1159.42 1.00 417 12 11 1 TRUE 0.49
non-small cell lung cancer RAS_12C STK11 Any mutation 19 78 TMB quintile 3 1.43 0.46 2.32 1587.91 1.00 539 11 70 8 TRUE 2.64
non-small cell lung cancer RAS_12C STK11 Any mutation 42 161 TMB quintile 4 0.99 0.36 1.59 1426.70 1.00 579 25 144 17 TRUE 2.71
non-small cell lung cancer RAS_12C STK11 Any mutation 94 283 TMB quintile 5 0.10 -0.41 0.56 1422.23 1.00 882 72 261 22 TRUE 0.16
non-small cell lung cancer RAS_12C STK11 Any mutation 168 534 TMB overall 0.81 -0.29 1.93 1513.44 1.00 2417 120 486 48 TRUE 0.83
non-small cell lung cancer RAS_12C EP300 Any mutation 93 77 TMB quintile 5 0.14 -0.78 0.91 1526.01 1.00 1066 86 70 7 TRUE 0.13
non-small cell lung cancer RAS_12C EP300 Any mutation 93 77 TMB overall 0.12 -4.55 4.56 1546.11 1.00 1066 86 70 7 TRUE 0.02
non-small cell lung cancer RAS_12C ERBB4 Any mutation 42 25 TMB quintile 4 0.00 -1.88 1.42 1395.02 1.00 697 40 23 2 TRUE 0.00
non-small cell lung cancer RAS_12C ERBB4 Any mutation 94 148 TMB quintile 5 -0.60 -1.43 0.11 1280.39 1.00 1013 87 141 7 TRUE 0.87
non-small cell lung cancer RAS_12C ERBB4 Any mutation 136 185 TMB overall -0.53 -3.09 1.69 1472.03 1.00 1719 127 176 9 TRUE 0.18
non-small cell lung cancer RAS_12C MED12 Any mutation 18 23 TMB quintile 3 -1.15 -3.14 0.32 1440.89 1.00 585 18 23 0 TRUE 0.71
non-small cell lung cancer RAS_12C MED12 Any mutation 42 32 TMB quintile 4 -0.94 -2.51 0.40 1403.80 1.00 689 41 31 1 TRUE 0.69
non-small cell lung cancer RAS_12C MED12 Any mutation 93 101 TMB quintile 5 -0.89 -1.94 0.00 1520.14 1.00 1042 89 97 4 TRUE 1.11
non-small cell lung cancer RAS_12C MED12 Any mutation 153 156 TMB overall -0.99 -2.50 0.20 1457.03 1.00 2316 148 151 5 TRUE 0.80
non-small cell lung cancer RAS_12C RBM10 Any mutation 13 29 TMB quintile 2 -0.39 -2.13 0.84 1353.53 1.00 399 13 29 0 FALSE 0.21
non-small cell lung cancer RAS_12C RBM10 Any mutation 18 46 TMB quintile 3 -0.50 -2.35 0.67 1377.76 1.00 563 18 46 0 FALSE 0.29
non-small cell lung cancer RAS_12C RBM10 Any mutation 43 90 TMB quintile 4 0.58 -0.16 1.33 1483.58 1.00 640 33 80 10 FALSE 0.89
non-small cell lung cancer RAS_12C RBM10 Any mutation 95 200 TMB quintile 5 -0.02 -0.60 0.53 1586.02 1.00 961 80 185 15 FALSE 0.03
non-small cell lung cancer RAS_12C RBM10 Any mutation 169 365 TMB overall -0.09 -1.17 0.77 1314.28 1.00 2563 144 340 25 FALSE 0.07
non-small cell lung cancer RAS_12C NF1 Any mutation 18 25 TMB quintile 3 -0.59 -2.30 1.05 1580.95 1.00 585 17 24 1 TRUE 0.31
non-small cell lung cancer RAS_12C NF1 Any mutation 42 59 TMB quintile 4 -1.10 -2.69 0.17 1425.56 1.00 670 41 58 1 TRUE 0.88
non-small cell lung cancer RAS_12C NF1 Any mutation 95 216 TMB quintile 5 -0.88 -1.72 -0.18 1317.83 1.00 956 87 208 8 TRUE 1.65
non-small cell lung cancer RAS_12C NF1 Any mutation 155 300 TMB overall -0.86 -2.31 0.57 1612.50 1.00 2211 145 290 10 TRUE 0.66
non-small cell lung cancer RAS_12C FLT1 Any mutation 42 21 TMB quintile 4 -1.57 -5.18 0.50 1398.29 1.00 700 42 21 0 FALSE 0.54
non-small cell lung cancer RAS_12C FLT1 Any mutation 93 99 TMB quintile 5 -0.65 -1.72 0.23 1381.44 1.00 1046 88 94 5 FALSE 0.71
non-small cell lung cancer RAS_12C FLT1 Any mutation 135 120 TMB overall -1.07 -3.67 0.93 1400.62 1.00 1746 130 115 5 FALSE 0.47
non-small cell lung cancer RAS_12C EPHA5 Any mutation 42 48 TMB quintile 4 0.28 -0.92 1.26 1473.95 1.00 677 38 44 4 FALSE 0.21
non-small cell lung cancer RAS_12C EPHA5 Any mutation 93 191 TMB quintile 5 0.12 -0.52 0.67 1513.79 1.00 974 77 175 16 FALSE 0.17
non-small cell lung cancer RAS_12C EPHA5 Any mutation 135 250 TMB overall 0.00 -1.85 1.85 1617.66 1.00 1661 115 230 20 FALSE 0.00
non-small cell lung cancer RAS_12C AR Any mutation 42 16 TMB quintile 4 -1.48 -5.26 0.43 1288.36 1.00 704 42 16 0 TRUE 0.51
non-small cell lung cancer RAS_12C AR Any mutation 94 77 TMB quintile 5 -0.66 -1.87 0.30 1517.59 1.00 1064 90 73 4 TRUE 0.63
non-small cell lung cancer RAS_12C AR Any mutation 136 93 TMB overall -1.07 -3.69 0.83 1511.45 1.00 1768 132 89 4 TRUE 0.47
non-small cell lung cancer RAS_12C ROS1 Any mutation 42 13 TMB quintile 4 -1.76 -5.53 0.47 1445.90 1.00 707 42 13 0 TRUE 0.59
non-small cell lung cancer RAS_12C ROS1 Any mutation 94 80 TMB quintile 5 -1.00 -2.33 0.11 1448.48 1.00 1057 91 77 3 TRUE 0.96
non-small cell lung cancer RAS_12C ROS1 Any mutation 136 93 TMB overall -1.33 -4.18 0.69 1525.47 1.00 1764 133 90 3 TRUE 0.56
non-small cell lung cancer RAS_12C PIK3CG Any mutation 42 16 TMB quintile 4 -0.29 -2.27 1.32 1508.44 1.00 705 41 15 1 FALSE 0.13
non-small cell lung cancer RAS_12C PIK3CG Any mutation 95 150 TMB quintile 5 -0.33 -1.12 0.34 1601.18 1.00 1005 86 141 9 FALSE 0.42
non-small cell lung cancer RAS_12C PIK3CG Any mutation 137 166 TMB overall -0.27 -2.48 1.78 1340.62 1.00 1710 127 156 10 FALSE 0.10
non-small cell lung cancer RAS_12C EGFR Any mutation 13 200 TMB quintile 2 -3.48 -6.12 -1.75 1316.25 1.00 250 13 200 0 TRUE 2.62
non-small cell lung cancer RAS_12C EGFR Any mutation 18 287 TMB quintile 3 -3.59 -6.35 -1.80 1479.16 1.00 378 18 287 0 TRUE 2.60
non-small cell lung cancer RAS_12C EGFR Any mutation 42 256 TMB quintile 4 -3.67 -6.32 -1.96 1262.19 1.00 528 42 256 0 TRUE 3.00
non-small cell lung cancer RAS_12C EGFR Any mutation 93 175 TMB quintile 5 -1.72 -2.99 -0.67 1366.88 1.00 1000 88 170 5 TRUE 2.41
non-small cell lung cancer RAS_12C EGFR Any mutation 166 918 TMB overall -3.08 -5.01 -1.66 1197.80 1.00 2156 161 913 5 TRUE 3.51
non-small cell lung cancer RAS_12C ARID1B Any mutation 18 11 TMB quintile 3 -0.93 -3.26 0.93 1394.11 1.00 597 18 11 0 TRUE 0.40
non-small cell lung cancer RAS_12C ARID1B Any mutation 42 16 TMB quintile 4 -0.60 -2.48 0.91 1478.24 1.00 706 41 15 1 TRUE 0.30
non-small cell lung cancer RAS_12C ARID1B Any mutation 93 77 TMB quintile 5 -0.78 -2.08 0.24 1222.05 1.00 1061 90 74 3 TRUE 0.74
non-small cell lung cancer RAS_12C ARID1B Any mutation 153 104 TMB overall -0.80 -2.54 0.66 1419.51 1.00 2364 149 100 4 TRUE 0.46
non-small cell lung cancer RAS_12C MET Any mutation 13 21 TMB quintile 2 -0.88 -2.41 0.43 1461.04 1.00 408 13 21 0 TRUE 0.67
non-small cell lung cancer RAS_12C MET Any mutation 18 30 TMB quintile 3 -0.73 -2.18 0.62 1382.15 1.00 585 17 29 1 TRUE 0.53
non-small cell lung cancer RAS_12C MET Any mutation 42 34 TMB quintile 4 -0.98 -2.52 0.19 1438.10 1.00 692 42 34 0 TRUE 0.81
non-small cell lung cancer RAS_12C MET Any mutation 93 47 TMB quintile 5 -0.66 -1.99 0.35 1473.65 1.00 1088 90 44 3 TRUE 0.60
non-small cell lung cancer RAS_12C MET Any mutation 166 132 TMB overall -0.81 -2.12 0.30 1438.23 1.00 2773 162 128 4 TRUE 0.73
non-small cell lung cancer RAS_12C BRAF Any mutation 13 11 TMB quintile 2 -0.97 -2.83 0.60 1499.35 1.00 417 13 11 0 TRUE 0.57
non-small cell lung cancer RAS_12C BRAF Any mutation 18 13 TMB quintile 3 -0.95 -2.92 0.68 1511.15 1.00 595 18 13 0 TRUE 0.51
non-small cell lung cancer RAS_12C BRAF Any mutation 42 46 TMB quintile 4 -0.64 -2.12 0.55 1339.34 1.00 677 40 44 2 TRUE 0.48
non-small cell lung cancer RAS_12C BRAF Any mutation 93 101 TMB quintile 5 -0.80 -1.89 0.05 1499.30 1.00 1035 89 97 4 TRUE 0.97
non-small cell lung cancer RAS_12C BRAF Any mutation 166 171 TMB overall -0.83 -2.21 0.37 1568.30 1.00 2724 160 165 6 TRUE 0.70
non-small cell lung cancer RAS_12C CARD11 Any mutation 42 18 TMB quintile 4 0.78 -0.60 2.02 1427.79 1.00 705 39 15 3 FALSE 0.62
non-small cell lung cancer RAS_12C CARD11 Any mutation 94 97 TMB quintile 5 -0.03 -0.86 0.69 1257.48 1.00 1045 87 90 7 FALSE 0.03
non-small cell lung cancer RAS_12C CARD11 Any mutation 136 115 TMB overall 0.38 -1.53 2.15 1621.70 1.00 1750 126 105 10 FALSE 0.17
non-small cell lung cancer RAS_12C INPP4B Any mutation 42 17 TMB quintile 4 -0.02 -1.86 1.33 1330.90 1.00 704 41 16 1 FALSE 0.01
non-small cell lung cancer RAS_12C INPP4B Any mutation 94 87 TMB quintile 5 0.30 -0.48 0.96 1380.29 1.00 1060 85 78 9 FALSE 0.38
non-small cell lung cancer RAS_12C INPP4B Any mutation 136 104 TMB overall 0.12 -1.60 1.71 1518.41 1.00 1764 126 94 10 FALSE 0.05
non-small cell lung cancer RAS_12C NFE2L2 Any mutation 42 31 TMB quintile 4 -2.02 -5.02 -0.18 1312.84 1.00 695 42 31 0 FALSE 0.97
non-small cell lung cancer RAS_12C NFE2L2 Any mutation 93 83 TMB quintile 5 -1.67 -3.43 -0.33 1464.11 1.00 1056 91 81 2 FALSE 1.49
non-small cell lung cancer RAS_12C NFE2L2 Any mutation 135 114 TMB overall -1.81 -4.23 -0.02 1370.66 1.00 1751 133 112 2 FALSE 1.09
non-small cell lung cancer RAS_12C GLI1 Any mutation 40 16 TMB quintile 4 -0.22 -2.17 1.15 1462.51 1.00 627 39 15 1 FALSE 0.10
non-small cell lung cancer RAS_12C GLI1 Any mutation 85 77 TMB quintile 5 -0.05 -1.03 0.77 1371.53 1.00 951 79 71 6 FALSE 0.04
non-small cell lung cancer RAS_12C GLI1 Any mutation 125 93 TMB overall -0.13 -1.90 1.59 1205.74 1.00 1578 118 86 7 FALSE 0.05
non-small cell lung cancer RAS_12C ZFHX3 Any mutation 18 13 TMB quintile 3 -0.74 -3.16 1.04 1505.67 1.00 539 18 13 0 FALSE 0.30
non-small cell lung cancer RAS_12C ZFHX3 Any mutation 40 30 TMB quintile 4 0.08 -1.23 1.26 1558.16 1.00 612 37 27 3 FALSE 0.05
non-small cell lung cancer RAS_12C ZFHX3 Any mutation 84 112 TMB quintile 5 -0.76 -1.75 0.06 1416.36 1.00 917 80 108 4 FALSE 0.96
non-small cell lung cancer RAS_12C ZFHX3 Any mutation 142 155 TMB overall -0.48 -2.06 0.99 1520.29 1.00 2068 135 148 7 FALSE 0.27
non-small cell lung cancer RAS_12C MGA Any mutation 18 14 TMB quintile 3 0.00 -1.78 1.59 1363.39 1.00 540 17 13 1 FALSE 0.00
non-small cell lung cancer RAS_12C MGA Any mutation 40 24 TMB quintile 4 -0.99 -3.61 0.56 1258.17 1.00 615 40 24 0 FALSE 0.45
non-small cell lung cancer RAS_12C MGA Any mutation 85 140 TMB quintile 5 0.10 -0.55 0.72 1524.90 1.00 907 73 128 12 FALSE 0.12
non-small cell lung cancer RAS_12C MGA Any mutation 143 178 TMB overall -0.27 -1.94 1.07 1406.70 1.00 2062 130 165 13 FALSE 0.14
non-small cell lung cancer RAS_12C AMER1 Any mutation 42 18 TMB quintile 4 1.76 0.52 2.85 1427.02 1.00 707 37 13 5 FALSE 2.52
non-small cell lung cancer RAS_12C AMER1 Any mutation 94 107 TMB quintile 5 0.21 -0.49 0.84 1475.20 1.00 1043 84 97 10 FALSE 0.27
non-small cell lung cancer RAS_12C AMER1 Any mutation 136 142 TMB overall 0.45 -2.45 3.44 1565.80 1.00 1760 121 127 15 FALSE 0.12
non-small cell lung cancer RAS_12C EPHA7 Any mutation 40 14 TMB quintile 4 -1.47 -5.80 0.85 1396.16 1.00 624 40 14 0 FALSE 0.39
non-small cell lung cancer RAS_12C EPHA7 Any mutation 84 101 TMB quintile 5 -0.22 -1.11 0.56 1549.38 1.00 932 77 94 7 FALSE 0.21
non-small cell lung cancer RAS_12C EPHA7 Any mutation 124 115 TMB overall -0.78 -3.61 1.47 1383.94 1.00 1556 117 108 7 FALSE 0.26
non-small cell lung cancer KRAS_12C SPEN Any mutation 127 15 TMB quintile 4 -2.30 -6.31 -0.35 1321.48 1.00 620 127 15 0 FALSE 0.85
non-small cell lung cancer KRAS_12C SPEN Any mutation 223 87 TMB quintile 5 -1.11 -2.04 -0.35 1513.93 1.00 950 216 80 7 FALSE 2.13
non-small cell lung cancer KRAS_12C SPEN Any mutation 350 102 TMB overall -1.65 -4.47 0.31 1401.47 1.00 1570 343 95 7 FALSE 0.82
non-small cell lung cancer KRAS_12C KMT2C Any mutation 46 13 TMB quintile 3 -0.99 -3.36 0.65 1516.97 1.00 563 46 13 0 FALSE 0.46
non-small cell lung cancer KRAS_12C KMT2C Any mutation 127 36 TMB quintile 4 -0.16 -1.08 0.66 1374.46 1.00 604 121 30 6 FALSE 0.15
non-small cell lung cancer KRAS_12C KMT2C Any mutation 223 155 TMB quintile 5 -0.35 -0.83 0.09 1427.32 1.00 874 201 133 22 FALSE 0.87
non-small cell lung cancer KRAS_12C KMT2C Any mutation 396 204 TMB overall -0.48 -1.98 0.84 1479.46 1.00 2041 368 176 28 FALSE 0.32
non-small cell lung cancer KRAS_12C TP53 Any mutation 27 180 TMB quintile 2 -1.52 -2.48 -0.72 1311.48 1.00 240 23 176 4 TRUE 3.16
non-small cell lung cancer KRAS_12C TP53 Any mutation 46 324 TMB quintile 3 -1.43 -2.13 -0.80 1562.51 1.00 279 36 314 10 TRUE 4.54
non-small cell lung cancer KRAS_12C TP53 Any mutation 127 450 TMB quintile 4 -1.30 -1.73 -0.91 1548.76 1.00 250 88 411 39 TRUE 9.43
non-small cell lung cancer KRAS_12C TP53 Any mutation 233 996 TMB quintile 5 -1.18 -1.49 -0.89 1719.58 1.00 224 108 871 125 TRUE 13.91
non-small cell lung cancer KRAS_12C TP53 Any mutation 433 1950 TMB overall -1.33 -2.16 -0.52 1457.83 1.00 993 255 1772 178 TRUE 2.94
non-small cell lung cancer KRAS_12C ATRX Any mutation 127 32 TMB quintile 4 0.12 -0.70 0.92 1361.88 1.00 610 121 26 6 TRUE 0.11
non-small cell lung cancer KRAS_12C ATRX Any mutation 227 160 TMB quintile 5 0.39 -0.01 0.79 1401.03 1.00 900 189 122 38 TRUE 1.26
non-small cell lung cancer KRAS_12C ATRX Any mutation 354 192 TMB overall 0.29 -1.02 1.62 1500.50 1.00 1510 310 148 44 TRUE 0.17
non-small cell lung cancer KRAS_12C ATR Any mutation 46 12 TMB quintile 3 -0.35 -2.06 1.09 1489.95 1.00 569 45 11 1 FALSE 0.18
non-small cell lung cancer KRAS_12C ATR Any mutation 127 15 TMB quintile 4 -0.76 -2.31 0.46 1226.63 1.00 623 126 14 1 FALSE 0.57
non-small cell lung cancer KRAS_12C ATR Any mutation 222 93 TMB quintile 5 -0.10 -0.65 0.42 1656.89 1.00 926 206 77 16 FALSE 0.15
non-small cell lung cancer KRAS_12C ATR Any mutation 395 120 TMB overall -0.40 -1.71 0.84 1431.04 1.00 2118 377 102 18 FALSE 0.26
non-small cell lung cancer KRAS_12C PDGFRA Any mutation 127 16 TMB quintile 4 0.31 -0.80 1.33 1308.52 1.00 623 123 12 4 TRUE 0.24
non-small cell lung cancer KRAS_12C PDGFRA Any mutation 224 115 TMB quintile 5 0.12 -0.37 0.60 1457.05 1.00 914 201 92 23 TRUE 0.20
non-small cell lung cancer KRAS_12C PDGFRA Any mutation 351 131 TMB overall 0.22 -1.51 2.08 1437.94 1.00 1537 324 104 27 TRUE 0.09
non-small cell lung cancer KRAS_12C FLT4 Any mutation 127 14 TMB quintile 4 0.65 -0.46 1.76 1398.07 1.00 626 122 9 5 TRUE 0.61
non-small cell lung cancer KRAS_12C FLT4 Any mutation 223 74 TMB quintile 5 -0.21 -0.88 0.42 1469.86 1.00 941 212 63 11 TRUE 0.28
non-small cell lung cancer KRAS_12C FLT4 Any mutation 350 88 TMB overall 0.20 -1.43 2.07 1483.65 1.00 1567 334 72 16 TRUE 0.09
non-small cell lung cancer KRAS_12C PTPRD Any mutation 46 16 TMB quintile 3 -0.65 -2.95 1.01 1370.05 1.00 566 45 15 1 FALSE 0.27
non-small cell lung cancer KRAS_12C PTPRD Any mutation 127 53 TMB quintile 4 -0.55 -1.49 0.30 1451.05 1.00 589 121 47 6 FALSE 0.66
non-small cell lung cancer KRAS_12C PTPRD Any mutation 232 298 TMB quintile 5 -0.11 -0.45 0.22 1369.55 1.00 795 181 247 51 FALSE 0.27
non-small cell lung cancer KRAS_12C PTPRD Any mutation 405 384 TMB overall -0.64 -2.64 1.24 1628.81 1.00 1957 347 326 58 FALSE 0.29
non-small cell lung cancer KRAS_12C PIK3C2G Any mutation 127 12 TMB quintile 4 -0.92 -2.92 0.51 1231.48 1.00 621 126 11 1 FALSE 0.55
non-small cell lung cancer KRAS_12C PIK3C2G Any mutation 223 103 TMB quintile 5 -0.48 -1.11 0.10 1489.30 1.00 912 210 90 13 FALSE 0.93
non-small cell lung cancer KRAS_12C PIK3C2G Any mutation 350 115 TMB overall -0.67 -2.61 1.26 1573.80 1.00 1533 336 101 14 FALSE 0.30
non-small cell lung cancer KRAS_12C CREBBP Any mutation 46 11 TMB quintile 3 -0.28 -2.03 1.18 1591.12 1.00 570 45 10 1 TRUE 0.14
non-small cell lung cancer KRAS_12C CREBBP Any mutation 127 12 TMB quintile 4 -0.29 -1.66 0.98 1445.12 1.00 625 125 10 2 TRUE 0.18
non-small cell lung cancer KRAS_12C CREBBP Any mutation 222 106 TMB quintile 5 -0.56 -1.21 0.00 1553.12 1.00 916 210 94 12 TRUE 1.13
non-small cell lung cancer KRAS_12C CREBBP Any mutation 395 129 TMB overall -0.36 -1.73 1.03 1441.56 1.00 2111 380 114 15 TRUE 0.23
non-small cell lung cancer KRAS_12C DOT1L Any mutation 127 24 TMB quintile 4 -0.06 -0.93 0.80 1459.19 1.00 618 122 19 5 FALSE 0.05
non-small cell lung cancer KRAS_12C DOT1L Any mutation 223 75 TMB quintile 5 -0.33 -1.04 0.26 1356.96 1.00 936 213 65 10 FALSE 0.52
non-small cell lung cancer KRAS_12C DOT1L Any mutation 350 99 TMB overall -0.20 -1.35 0.93 1666.18 1.00 1554 335 84 15 FALSE 0.13
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 47 35 TMB quintile 3 0.62 -0.36 1.54 1502.10 1.00 554 41 29 6 FALSE 0.72
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 128 67 TMB quintile 4 0.07 -0.58 0.65 1412.26 1.00 583 116 55 12 FALSE 0.09
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 224 194 TMB quintile 5 -0.31 -0.72 0.10 1457.91 1.00 843 197 167 27 FALSE 0.88
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 399 296 TMB overall 0.12 -0.85 1.16 1446.57 1.00 1980 354 251 45 FALSE 0.09
non-small cell lung cancer KRAS_12C PTPRT Any mutation 46 17 TMB quintile 3 1.11 -0.27 2.21 1521.40 1.00 567 42 13 4 FALSE 1.11
non-small cell lung cancer KRAS_12C PTPRT Any mutation 127 38 TMB quintile 4 0.22 -0.61 1.01 1485.04 1.00 606 119 30 8 FALSE 0.22
non-small cell lung cancer KRAS_12C PTPRT Any mutation 224 272 TMB quintile 5 -0.54 -0.94 -0.16 1272.70 1.00 812 191 239 33 FALSE 2.11
non-small cell lung cancer KRAS_12C PTPRT Any mutation 397 348 TMB overall -0.09 -2.49 1.96 1340.15 1.00 1990 352 303 45 FALSE 0.03
non-small cell lung cancer KRAS_12C HGF Any mutation 127 27 TMB quintile 4 -0.03 -1.18 0.90 1542.61 1.00 614 122 22 5 FALSE 0.02
non-small cell lung cancer KRAS_12C HGF Any mutation 224 138 TMB quintile 5 -0.20 -0.74 0.29 1561.10 1.00 890 202 116 22 FALSE 0.38
non-small cell lung cancer KRAS_12C HGF Any mutation 351 180 TMB overall -0.48 -3.29 2.18 1524.55 1.00 1511 324 153 27 FALSE 0.15
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 27 18 TMB quintile 2 -0.40 -1.64 0.73 1393.68 1.00 397 26 17 1 TRUE 0.30
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 46 34 TMB quintile 3 -0.38 -1.47 0.54 1404.24 1.00 548 44 32 2 TRUE 0.34
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 128 56 TMB quintile 4 -0.50 -1.28 0.21 1458.68 1.00 585 122 50 6 TRUE 0.75
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 222 123 TMB quintile 5 -0.23 -0.72 0.24 1359.60 1.00 906 203 104 19 TRUE 0.44
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 423 231 TMB overall -0.38 -1.21 0.36 1393.61 1.00 2436 395 203 28 TRUE 0.46
non-small cell lung cancer KRAS_12C ALK Any mutation 46 13 TMB quintile 3 -0.25 -2.43 1.43 1457.99 1.00 569 45 12 1 TRUE 0.10
non-small cell lung cancer KRAS_12C ALK Any mutation 127 22 TMB quintile 4 0.26 -0.79 1.23 1308.50 1.00 619 122 17 5 TRUE 0.20
non-small cell lung cancer KRAS_12C ALK Any mutation 222 118 TMB quintile 5 0.20 -0.28 0.65 1415.38 1.00 914 197 93 25 TRUE 0.39
non-small cell lung cancer KRAS_12C ALK Any mutation 395 164 TMB overall -0.09 -1.99 1.77 1529.38 1.00 2111 364 133 31 TRUE 0.03
non-small cell lung cancer KRAS_12C PTEN Any mutation 46 17 TMB quintile 3 -0.92 -2.73 0.59 1394.32 1.00 564 45 16 1 TRUE 0.59
non-small cell lung cancer KRAS_12C PTEN Any mutation 127 27 TMB quintile 4 -1.75 -4.24 -0.37 1445.09 1.00 609 127 27 0 TRUE 1.13
non-small cell lung cancer KRAS_12C PTEN Any mutation 222 75 TMB quintile 5 -0.67 -1.48 -0.03 1355.93 1.00 941 213 66 9 TRUE 1.14
non-small cell lung cancer KRAS_12C PTEN Any mutation 395 119 TMB overall -1.11 -2.69 0.16 1434.91 1.00 2114 385 109 10 TRUE 0.90
non-small cell lung cancer KRAS_12C BCOR Any mutation 127 22 TMB quintile 4 -0.53 -1.85 0.45 1347.23 1.00 616 125 20 2 FALSE 0.42
non-small cell lung cancer KRAS_12C BCOR Any mutation 226 92 TMB quintile 5 0.03 -0.53 0.55 1351.92 1.00 931 208 74 18 FALSE 0.04
non-small cell lung cancer KRAS_12C BCOR Any mutation 353 114 TMB overall -0.24 -1.89 1.10 1325.84 1.00 1547 333 94 20 FALSE 0.13
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 27 12 TMB quintile 2 -0.60 -1.93 0.60 1501.89 1.00 403 26 11 1 TRUE 0.45
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 46 22 TMB quintile 3 -0.94 -2.40 0.20 1481.26 1.00 558 46 22 0 TRUE 0.82
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 128 33 TMB quintile 4 -0.57 -1.54 0.30 1432.26 1.00 608 124 29 4 TRUE 0.65
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 222 47 TMB quintile 5 -0.70 -1.53 0.10 1358.83 1.00 959 217 42 5 TRUE 1.06
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 423 114 TMB overall -0.70 -1.67 0.24 1349.07 1.00 2528 413 104 10 TRUE 0.85
non-small cell lung cancer KRAS_12C ARID1A Any mutation 46 12 TMB quintile 3 -0.24 -1.83 1.26 1385.31 1.00 569 45 11 1 TRUE 0.12
non-small cell lung cancer KRAS_12C ARID1A Any mutation 127 56 TMB quintile 4 -0.36 -1.14 0.36 1573.98 1.00 589 120 49 7 TRUE 0.44
non-small cell lung cancer KRAS_12C ARID1A Any mutation 228 187 TMB quintile 5 -0.06 -0.46 0.33 1342.55 1.00 861 195 154 33 TRUE 0.11
non-small cell lung cancer KRAS_12C ARID1A Any mutation 401 255 TMB overall -0.20 -1.50 1.17 1390.79 1.00 2019 360 214 41 TRUE 0.12
non-small cell lung cancer KRAS_12C FAT1 Any mutation 46 16 TMB quintile 3 0.22 -1.49 1.66 1428.78 1.00 566 44 14 2 FALSE 0.11
non-small cell lung cancer KRAS_12C FAT1 Any mutation 127 43 TMB quintile 4 0.08 -0.74 0.82 1608.45 1.00 605 119 35 8 FALSE 0.08
non-small cell lung cancer KRAS_12C FAT1 Any mutation 226 227 TMB quintile 5 -0.12 -0.49 0.26 1476.76 1.00 831 188 189 38 FALSE 0.26
non-small cell lung cancer KRAS_12C FAT1 Any mutation 399 300 TMB overall -0.15 -1.95 1.59 1423.46 1.00 2009 351 252 48 FALSE 0.06
non-small cell lung cancer KRAS_12C NCOR1 Any mutation 127 21 TMB quintile 4 -0.31 -1.37 0.62 1529.82 1.00 618 124 18 3 FALSE 0.28
non-small cell lung cancer KRAS_12C NCOR1 Any mutation 224 71 TMB quintile 5 -0.23 -0.93 0.38 1577.51 1.00 948 213 60 11 FALSE 0.32
non-small cell lung cancer KRAS_12C NCOR1 Any mutation 351 92 TMB overall -0.26 -1.44 0.97 1357.58 1.00 1566 337 78 14 FALSE 0.18
non-small cell lung cancer KRAS_12C POLE Any mutation 127 20 TMB quintile 4 -0.08 -1.28 0.86 1564.07 1.00 618 124 17 3 TRUE 0.05
non-small cell lung cancer KRAS_12C POLE Any mutation 223 102 TMB quintile 5 0.45 -0.01 0.93 1418.06 1.00 931 197 76 26 TRUE 1.26
non-small cell lung cancer KRAS_12C POLE Any mutation 350 122 TMB overall 0.21 -1.33 1.82 1802.95 1.00 1549 321 93 29 TRUE 0.10
non-small cell lung cancer KRAS_12C NOTCH2 Any mutation 127 16 TMB quintile 4 -0.24 -1.49 0.92 1477.98 1.00 620 124 13 3 TRUE 0.16
non-small cell lung cancer KRAS_12C NOTCH2 Any mutation 222 81 TMB quintile 5 -0.69 -1.45 -0.06 1396.19 1.00 930 214 73 8 TRUE 1.24
non-small cell lung cancer KRAS_12C NOTCH2 Any mutation 349 97 TMB overall -0.46 -2.08 1.19 1265.35 1.00 1550 338 86 11 TRUE 0.24
non-small cell lung cancer KRAS_12C KMT2A Any mutation 127 16 TMB quintile 4 -0.14 -1.30 0.98 1493.29 1.00 622 124 13 3 FALSE 0.09
non-small cell lung cancer KRAS_12C KMT2A Any mutation 222 80 TMB quintile 5 -0.34 -1.00 0.28 1303.39 1.00 937 211 69 11 FALSE 0.52
non-small cell lung cancer KRAS_12C KMT2A Any mutation 349 96 TMB overall -0.22 -1.65 1.36 1534.62 1.00 1559 335 82 14 FALSE 0.11
non-small cell lung cancer KRAS_12C PAK7 Any mutation 127 13 TMB quintile 4 -0.35 -1.80 0.96 1428.75 1.00 621 125 11 2 FALSE 0.22
non-small cell lung cancer KRAS_12C PAK7 Any mutation 222 95 TMB quintile 5 -0.47 -1.10 0.11 1404.74 1.00 921 210 83 12 FALSE 0.86
non-small cell lung cancer KRAS_12C PAK7 Any mutation 349 108 TMB overall -0.42 -2.21 1.51 1420.11 1.00 1542 335 94 14 FALSE 0.19
non-small cell lung cancer KRAS_12C STAG2 Any mutation 127 19 TMB quintile 4 -0.20 -1.20 0.78 1421.98 1.00 619 124 16 3 TRUE 0.16
non-small cell lung cancer KRAS_12C STAG2 Any mutation 222 76 TMB quintile 5 -0.17 -0.84 0.43 1272.33 1.00 943 210 64 12 TRUE 0.22
non-small cell lung cancer KRAS_12C STAG2 Any mutation 349 95 TMB overall -0.22 -1.60 0.98 1412.40 1.00 1562 334 80 15 TRUE 0.13
non-small cell lung cancer KRAS_12C TERT Any mutation 47 13 TMB quintile 3 0.76 -0.40 1.93 1589.53 1.00 570 44 10 3 TRUE 0.72
non-small cell lung cancer KRAS_12C TERT Any mutation 127 34 TMB quintile 4 0.16 -0.67 0.90 1367.32 1.00 608 121 28 6 TRUE 0.16
non-small cell lung cancer KRAS_12C TERT Any mutation 224 98 TMB quintile 5 0.42 -0.03 0.85 1489.86 1.00 932 200 74 24 TRUE 1.17
non-small cell lung cancer KRAS_12C TERT Any mutation 398 145 TMB overall 0.44 -0.58 1.50 1554.64 1.00 2110 365 112 33 TRUE 0.41
non-small cell lung cancer KRAS_12C BRCA2 Any mutation 127 23 TMB quintile 4 0.20 -0.91 1.19 1359.43 1.00 618 122 18 5 TRUE 0.15
non-small cell lung cancer KRAS_12C BRCA2 Any mutation 222 89 TMB quintile 5 -0.22 -0.86 0.35 1477.85 1.00 931 208 75 14 TRUE 0.31
non-small cell lung cancer KRAS_12C BRCA2 Any mutation 349 126 TMB overall -0.35 -3.27 2.32 1473.71 1.00 1558 330 107 19 TRUE 0.10
non-small cell lung cancer KRAS_12C NOTCH3 Any mutation 127 21 TMB quintile 4 -0.01 -1.25 1.02 1477.28 1.00 619 123 17 4 TRUE 0.01
non-small cell lung cancer KRAS_12C NOTCH3 Any mutation 222 82 TMB quintile 5 -0.32 -0.98 0.29 1558.18 1.00 936 210 70 12 TRUE 0.48
non-small cell lung cancer KRAS_12C NOTCH3 Any mutation 349 114 TMB overall -0.53 -3.43 2.09 1618.36 1.00 1564 333 98 16 TRUE 0.16
non-small cell lung cancer KRAS_12C NOTCH4 Any mutation 127 17 TMB quintile 4 -1.14 -2.93 0.13 1538.82 1.00 616 126 16 1 TRUE 0.84
non-small cell lung cancer KRAS_12C NOTCH4 Any mutation 222 107 TMB quintile 5 -0.57 -1.22 0.01 1430.11 1.00 906 209 94 13 TRUE 1.19
non-small cell lung cancer KRAS_12C NOTCH4 Any mutation 349 124 TMB overall -0.83 -2.58 0.87 1551.14 1.00 1522 335 110 14 TRUE 0.47
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 27 12 TMB quintile 2 -0.44 -2.36 1.05 1461.68 1.00 402 27 12 0 FALSE 0.21
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 46 50 TMB quintile 3 0.63 -0.26 1.47 1480.68 1.00 537 39 43 7 FALSE 0.81
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 129 129 TMB quintile 4 0.73 0.28 1.15 1447.46 1.00 543 94 94 35 FALSE 2.87
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 225 336 TMB quintile 5 -0.17 -0.50 0.15 1526.47 1.00 734 171 282 54 FALSE 0.50
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 427 527 TMB overall 0.17 -1.01 1.23 1503.61 1.00 2216 331 431 96 FALSE 0.12
non-small cell lung cancer KRAS_12C KDM5C Any mutation 127 16 TMB quintile 4 -0.33 -1.55 0.71 1400.05 1.00 621 125 14 2 FALSE 0.24
non-small cell lung cancer KRAS_12C KDM5C Any mutation 223 70 TMB quintile 5 0.00 -0.66 0.59 1301.14 1.00 948 210 57 13 FALSE 0.00
non-small cell lung cancer KRAS_12C KDM5C Any mutation 350 86 TMB overall -0.15 -1.62 1.16 1458.26 1.00 1569 335 71 15 FALSE 0.08
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 46 33 TMB quintile 3 0.11 -0.94 1.07 1474.70 1.00 552 42 29 4 TRUE 0.08
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 127 43 TMB quintile 4 -0.83 -1.91 0.04 1521.52 1.00 596 124 40 3 TRUE 0.98
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 226 178 TMB quintile 5 -0.46 -0.93 -0.03 1410.71 1.00 858 203 155 23 TRUE 1.32
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 399 254 TMB overall -0.40 -1.49 0.74 1325.58 1.00 2006 369 224 30 TRUE 0.33
non-small cell lung cancer KRAS_12C EPHB1 Any mutation 127 19 TMB quintile 4 -0.30 -1.69 0.84 1310.62 1.00 619 124 16 3 FALSE 0.19
non-small cell lung cancer KRAS_12C EPHB1 Any mutation 223 117 TMB quintile 5 -0.48 -1.05 0.06 1362.03 1.00 904 208 102 15 FALSE 1.01
non-small cell lung cancer KRAS_12C EPHB1 Any mutation 350 152 TMB overall -0.69 -3.48 1.96 1497.56 1.00 1532 332 134 18 FALSE 0.21
non-small cell lung cancer KRAS_12C SMAD4 Any mutation 46 21 TMB quintile 3 -0.54 -1.90 0.55 1260.06 1.00 560 45 20 1 TRUE 0.40
non-small cell lung cancer KRAS_12C SMAD4 Any mutation 127 36 TMB quintile 4 -0.80 -1.89 0.06 1337.80 1.00 605 125 34 2 TRUE 0.93
non-small cell lung cancer KRAS_12C SMAD4 Any mutation 222 49 TMB quintile 5 -0.09 -0.84 0.58 1568.79 1.00 962 212 39 10 TRUE 0.09
non-small cell lung cancer KRAS_12C SMAD4 Any mutation 395 106 TMB overall -0.47 -1.65 0.56 1546.72 1.00 2127 382 93 13 TRUE 0.41
non-small cell lung cancer KRAS_12C ATM Any mutation 27 15 TMB quintile 2 1.00 -0.08 2.05 1382.47 1.00 403 24 12 3 TRUE 1.16
non-small cell lung cancer KRAS_12C ATM Any mutation 46 20 TMB quintile 3 0.76 -0.20 1.68 1376.01 1.00 563 43 17 3 TRUE 0.93
non-small cell lung cancer KRAS_12C ATM Any mutation 130 76 TMB quintile 4 0.95 0.46 1.44 1350.65 1.00 591 106 52 24 TRUE 3.72
non-small cell lung cancer KRAS_12C ATM Any mutation 232 166 TMB quintile 5 0.72 0.35 1.07 1447.59 1.00 893 184 118 48 TRUE 3.87
non-small cell lung cancer KRAS_12C ATM Any mutation 435 277 TMB overall 0.86 0.07 1.66 1495.51 1.00 2450 357 199 78 TRUE 1.46
non-small cell lung cancer KRAS_12C RB1 Any mutation 46 33 TMB quintile 3 -1.17 -2.63 0.01 1397.58 1.00 548 45 32 1 TRUE 1.14
non-small cell lung cancer KRAS_12C RB1 Any mutation 127 50 TMB quintile 4 -1.40 -2.56 -0.47 1436.38 1.00 587 125 48 2 TRUE 2.11
non-small cell lung cancer KRAS_12C RB1 Any mutation 222 124 TMB quintile 5 -0.98 -1.64 -0.38 1440.14 1.00 893 211 113 11 TRUE 2.70
non-small cell lung cancer KRAS_12C RB1 Any mutation 395 207 TMB overall -1.17 -2.23 -0.22 1402.99 1.00 2028 381 193 14 TRUE 1.66
non-small cell lung cancer KRAS_12C KMT2D Any mutation 46 15 TMB quintile 3 -0.51 -2.55 1.20 1647.12 1.00 566 45 14 1 FALSE 0.22
non-small cell lung cancer KRAS_12C KMT2D Any mutation 127 42 TMB quintile 4 -0.28 -1.24 0.52 1544.40 1.00 602 121 36 6 FALSE 0.28
non-small cell lung cancer KRAS_12C KMT2D Any mutation 224 251 TMB quintile 5 -0.47 -0.86 -0.07 1338.88 1.00 821 192 219 32 FALSE 1.67
non-small cell lung cancer KRAS_12C KMT2D Any mutation 397 320 TMB overall -0.56 -2.31 1.18 1519.34 1.00 1997 358 281 39 FALSE 0.29
non-small cell lung cancer KRAS_12C APC Any mutation 46 20 TMB quintile 3 -0.84 -2.42 0.50 1522.54 1.00 561 45 19 1 TRUE 0.59
non-small cell lung cancer KRAS_12C APC Any mutation 127 31 TMB quintile 4 -1.31 -2.73 -0.22 1530.62 1.00 605 126 30 1 TRUE 1.33
non-small cell lung cancer KRAS_12C APC Any mutation 225 101 TMB quintile 5 -0.46 -1.07 0.09 1600.91 1.00 920 211 87 14 TRUE 0.89
non-small cell lung cancer KRAS_12C APC Any mutation 398 152 TMB overall -0.86 -2.18 0.22 1464.27 1.00 2086 382 136 16 TRUE 0.81
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 27 14 TMB quintile 2 -3.38 -6.22 -1.19 1516.15 1.00 400 27 14 0 TRUE 2.12
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 46 27 TMB quintile 3 -3.42 -6.27 -1.35 1528.63 1.00 553 46 27 0 TRUE 2.24
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 127 32 TMB quintile 4 -3.49 -6.22 -1.56 1498.13 1.01 605 127 32 0 TRUE 2.38
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 222 40 TMB quintile 5 -3.20 -5.70 -1.43 1480.02 1.01 965 221 39 1 TRUE 2.36
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 422 113 TMB overall -3.36 -5.94 -1.50 1463.27 1.01 2523 421 112 1 TRUE 2.50
non-small cell lung cancer KRAS_12C ARID2 Any mutation 46 19 TMB quintile 3 -0.79 -2.65 0.55 1539.67 1.00 561 46 19 0 FALSE 0.46
non-small cell lung cancer KRAS_12C ARID2 Any mutation 127 35 TMB quintile 4 -0.28 -1.25 0.55 1214.53 1.00 607 122 30 5 FALSE 0.27
non-small cell lung cancer KRAS_12C ARID2 Any mutation 223 111 TMB quintile 5 0.02 -0.48 0.50 1339.17 1.00 921 202 90 21 FALSE 0.03
non-small cell lung cancer KRAS_12C ARID2 Any mutation 396 165 TMB overall -0.35 -1.56 0.63 1317.80 1.00 2089 370 139 26 FALSE 0.26
non-small cell lung cancer KRAS_12C MTOR Any mutation 46 14 TMB quintile 3 0.08 -1.25 1.16 1487.96 1.00 567 45 13 1 TRUE 0.05
non-small cell lung cancer KRAS_12C MTOR Any mutation 127 21 TMB quintile 4 0.16 -0.88 0.97 1450.49 1.00 619 123 17 4 TRUE 0.13
non-small cell lung cancer KRAS_12C MTOR Any mutation 224 70 TMB quintile 5 0.43 -0.10 0.95 1557.19 1.00 949 206 52 18 TRUE 0.96
non-small cell lung cancer KRAS_12C MTOR Any mutation 397 105 TMB overall 0.23 -0.81 1.18 1399.43 1.00 2135 374 82 23 TRUE 0.19
non-small cell lung cancer KRAS_12C NOTCH1 Any mutation 127 15 TMB quintile 4 -0.54 -1.97 0.73 1418.86 1.00 622 125 13 2 TRUE 0.37
non-small cell lung cancer KRAS_12C NOTCH1 Any mutation 223 97 TMB quintile 5 -0.60 -1.27 0.00 1425.49 1.00 920 212 86 11 TRUE 1.18
non-small cell lung cancer KRAS_12C NOTCH1 Any mutation 350 112 TMB overall -0.58 -2.18 1.23 1436.27 1.00 1542 337 99 13 TRUE 0.28
non-small cell lung cancer KRAS_12C SETD2 Any mutation 27 14 TMB quintile 2 -0.70 -2.48 0.66 1335.08 1.00 400 27 14 0 FALSE 0.41
non-small cell lung cancer KRAS_12C SETD2 Any mutation 46 22 TMB quintile 3 -0.88 -2.84 0.42 1520.08 1.00 564 46 22 0 FALSE 0.54
non-small cell lung cancer KRAS_12C SETD2 Any mutation 127 59 TMB quintile 4 -0.28 -1.01 0.39 1484.02 1.00 593 119 51 8 FALSE 0.36
non-small cell lung cancer KRAS_12C SETD2 Any mutation 227 110 TMB quintile 5 0.22 -0.26 0.69 1542.78 1.00 927 202 85 25 FALSE 0.46
non-small cell lung cancer KRAS_12C SETD2 Any mutation 427 205 TMB overall -0.41 -1.54 0.51 1346.43 1.00 2484 394 172 33 FALSE 0.36
non-small cell lung cancer KRAS_12C PBRM1 Any mutation 127 21 TMB quintile 4 -0.32 -1.45 0.59 1256.87 1.00 620 124 18 3 TRUE 0.27
non-small cell lung cancer KRAS_12C PBRM1 Any mutation 222 79 TMB quintile 5 -0.31 -1.00 0.37 591.82 1.01 942 211 68 11 TRUE 0.45
non-small cell lung cancer KRAS_12C PBRM1 Any mutation 349 100 TMB overall -0.30 -1.71 0.91 1025.83 1.00 1562 335 86 14 TRUE 0.19
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 46 15 TMB quintile 3 -1.77 -5.68 0.66 1507.70 1.00 565 46 15 0 FALSE 0.59
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 127 28 TMB quintile 4 0.59 -0.28 1.40 1567.92 1.00 615 119 20 8 FALSE 0.75
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 228 182 TMB quintile 5 0.05 -0.35 0.44 1279.37 1.00 866 193 147 35 FALSE 0.09
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 401 237 TMB overall -0.52 -2.87 1.45 1320.51 1.00 2054 358 194 43 FALSE 0.20
non-small cell lung cancer KRAS_12C KDR Any mutation 127 21 TMB quintile 4 0.63 -0.37 1.62 1596.80 1.00 621 120 14 7 TRUE 0.69
non-small cell lung cancer KRAS_12C KDR Any mutation 224 109 TMB quintile 5 -0.24 -0.82 0.28 1371.25 1.00 911 208 93 16 TRUE 0.39
non-small cell lung cancer KRAS_12C KDR Any mutation 351 130 TMB overall 0.18 -1.43 1.90 1380.11 1.00 1532 328 107 23 TRUE 0.08
non-small cell lung cancer KRAS_12C TET1 Any mutation 127 16 TMB quintile 4 -0.64 -2.45 0.77 1235.79 1.00 618 125 14 2 FALSE 0.36
non-small cell lung cancer KRAS_12C TET1 Any mutation 223 89 TMB quintile 5 -0.32 -0.96 0.26 1506.78 1.00 928 210 76 13 FALSE 0.52
non-small cell lung cancer KRAS_12C TET1 Any mutation 350 120 TMB overall -0.84 -3.80 2.20 1484.38 1.00 1551 335 105 15 FALSE 0.24
non-small cell lung cancer KRAS_12C TBX3 Any mutation 127 11 TMB quintile 4 0.32 -0.97 1.62 1523.72 1.00 627 124 8 3 FALSE 0.21
non-small cell lung cancer KRAS_12C TBX3 Any mutation 222 108 TMB quintile 5 -0.09 -0.62 0.42 1481.46 1.00 919 204 90 18 FALSE 0.14
non-small cell lung cancer KRAS_12C TBX3 Any mutation 349 119 TMB overall 0.13 -1.73 2.16 1511.63 1.00 1546 328 98 21 FALSE 0.05
non-small cell lung cancer KRAS_12C NTRK3 Any mutation 129 31 TMB quintile 4 1.26 0.51 2.03 1595.55 1.00 618 116 18 13 FALSE 2.92
non-small cell lung cancer KRAS_12C NTRK3 Any mutation 224 144 TMB quintile 5 0.42 0.02 0.81 1384.69 1.00 903 189 109 35 FALSE 1.34
non-small cell lung cancer KRAS_12C NTRK3 Any mutation 353 195 TMB overall 0.20 -3.38 3.15 1391.69 1.00 1528 305 147 48 FALSE 0.05
non-small cell lung cancer KRAS_12C GRIN2A Any mutation 46 17 TMB quintile 3 0.76 -0.40 1.98 1525.23 1.00 567 42 13 4 FALSE 0.64
non-small cell lung cancer KRAS_12C GRIN2A Any mutation 127 39 TMB quintile 4 -0.45 -1.43 0.38 1431.19 1.00 601 123 35 4 FALSE 0.49
non-small cell lung cancer KRAS_12C GRIN2A Any mutation 225 124 TMB quintile 5 -0.14 -0.66 0.35 1549.03 1.00 903 205 104 20 FALSE 0.23
non-small cell lung cancer KRAS_12C GRIN2A Any mutation 398 180 TMB overall 0.03 -1.12 1.23 1525.97 1.00 2071 370 152 28 FALSE 0.02
non-small cell lung cancer KRAS_12C STK11 Any mutation 27 12 TMB quintile 2 0.87 -0.45 2.07 1570.94 1.00 404 25 10 2 TRUE 0.78
non-small cell lung cancer KRAS_12C STK11 Any mutation 47 78 TMB quintile 3 1.26 0.64 1.87 1514.75 1.00 518 32 63 15 TRUE 4.13
non-small cell lung cancer KRAS_12C STK11 Any mutation 128 161 TMB quintile 4 1.48 1.11 1.88 1484.40 1.00 535 69 102 59 TRUE 12.97
non-small cell lung cancer KRAS_12C STK11 Any mutation 225 283 TMB quintile 5 0.09 -0.25 0.43 1520.18 1.00 782 172 230 53 TRUE 0.22
non-small cell lung cancer KRAS_12C STK11 Any mutation 427 534 TMB overall 0.92 -0.14 1.89 1394.68 1.00 2239 298 405 129 TRUE 1.15
non-small cell lung cancer KRAS_12C EP300 Any mutation 222 77 TMB quintile 5 -0.22 -0.89 0.40 1121.98 1.00 942 210 65 12 TRUE 0.31
non-small cell lung cancer KRAS_12C EP300 Any mutation 222 77 TMB overall -0.20 -4.59 4.33 1391.26 1.00 942 210 65 12 TRUE 0.04
non-small cell lung cancer KRAS_12C ERBB4 Any mutation 127 25 TMB quintile 4 -0.65 -2.00 0.42 1558.94 1.00 613 124 22 3 TRUE 0.53
non-small cell lung cancer KRAS_12C ERBB4 Any mutation 223 148 TMB quintile 5 -1.11 -1.79 -0.50 1464.55 1.00 888 212 137 11 TRUE 3.13
non-small cell lung cancer KRAS_12C ERBB4 Any mutation 350 185 TMB overall -1.10 -3.66 1.39 1410.38 1.00 1510 336 171 14 TRUE 0.42
non-small cell lung cancer KRAS_12C MED12 Any mutation 46 23 TMB quintile 3 -0.18 -1.30 0.88 1402.97 1.00 559 44 21 2 TRUE 0.12
non-small cell lung cancer KRAS_12C MED12 Any mutation 127 32 TMB quintile 4 -0.34 -1.24 0.50 1583.94 1.00 607 123 28 4 TRUE 0.36
non-small cell lung cancer KRAS_12C MED12 Any mutation 225 101 TMB quintile 5 -0.26 -0.86 0.24 1423.72 1.00 921 210 86 15 TRUE 0.46
non-small cell lung cancer KRAS_12C MED12 Any mutation 398 156 TMB overall -0.26 -1.20 0.66 1549.61 1.00 2087 377 135 21 TRUE 0.23
non-small cell lung cancer KRAS_12C RBM10 Any mutation 27 29 TMB quintile 2 -0.11 -1.28 0.79 1545.40 1.00 386 26 28 1 FALSE 0.08
non-small cell lung cancer KRAS_12C RBM10 Any mutation 46 46 TMB quintile 3 -0.03 -0.92 0.76 1558.83 1.00 538 43 43 3 FALSE 0.02
non-small cell lung cancer KRAS_12C RBM10 Any mutation 128 90 TMB quintile 4 0.66 0.16 1.12 1452.14 1.00 570 103 65 25 FALSE 2.04
non-small cell lung cancer KRAS_12C RBM10 Any mutation 225 200 TMB quintile 5 0.27 -0.09 0.65 1164.16 1.00 859 182 157 43 FALSE 0.88
non-small cell lung cancer KRAS_12C RBM10 Any mutation 426 365 TMB overall 0.19 -0.60 0.89 1390.44 1.00 2353 354 293 72 FALSE 0.21
non-small cell lung cancer KRAS_12C NF1 Any mutation 46 25 TMB quintile 3 -0.04 -1.37 1.14 1391.60 1.00 559 43 22 3 TRUE 0.02
non-small cell lung cancer KRAS_12C NF1 Any mutation 127 59 TMB quintile 4 -0.99 -1.95 -0.10 1435.72 1.00 588 123 55 4 TRUE 1.46
non-small cell lung cancer KRAS_12C NF1 Any mutation 225 216 TMB quintile 5 -0.74 -1.24 -0.30 1337.38 1.00 840 203 194 22 TRUE 2.83
non-small cell lung cancer KRAS_12C NF1 Any mutation 398 300 TMB overall -0.57 -1.71 0.63 1407.10 1.00 1987 369 271 29 TRUE 0.46
non-small cell lung cancer KRAS_12C FLT1 Any mutation 127 21 TMB quintile 4 0.67 -0.23 1.54 1446.82 1.00 622 120 14 7 FALSE 0.83
non-small cell lung cancer KRAS_12C FLT1 Any mutation 225 99 TMB quintile 5 0.04 -0.51 0.52 1559.66 1.00 927 207 81 18 FALSE 0.06
non-small cell lung cancer KRAS_12C FLT1 Any mutation 352 120 TMB overall 0.36 -1.22 1.90 1268.01 1.00 1549 327 95 25 FALSE 0.19
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 127 48 TMB quintile 4 0.35 -0.38 1.02 1434.10 1.00 599 116 37 11 FALSE 0.51
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 224 191 TMB quintile 5 0.29 -0.09 0.66 1483.99 1.00 869 182 149 42 FALSE 0.89
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 351 250 TMB overall -0.01 -2.50 2.18 1240.72 1.00 1478 298 197 53 FALSE 0.00
non-small cell lung cancer KRAS_12C AR Any mutation 127 16 TMB quintile 4 -0.06 -1.15 0.94 1309.40 1.00 622 124 13 3 TRUE 0.04
non-small cell lung cancer KRAS_12C AR Any mutation 225 77 TMB quintile 5 0.00 -0.62 0.54 1396.09 1.00 943 211 63 14 TRUE 0.00
non-small cell lung cancer KRAS_12C AR Any mutation 352 93 TMB overall -0.04 -1.45 1.38 1446.42 1.00 1565 335 76 17 TRUE 0.02
non-small cell lung cancer KRAS_12C ROS1 Any mutation 127 13 TMB quintile 4 -2.42 -7.10 -0.22 1292.34 1.00 622 127 13 0 TRUE 0.74
non-small cell lung cancer KRAS_12C ROS1 Any mutation 223 80 TMB quintile 5 -1.20 -2.10 -0.39 1562.37 1.00 931 217 74 6 TRUE 2.20
non-small cell lung cancer KRAS_12C ROS1 Any mutation 350 93 TMB overall -1.68 -4.81 0.59 1402.77 1.00 1553 344 87 6 TRUE 0.71
non-small cell lung cancer KRAS_12C PIK3CG Any mutation 127 16 TMB quintile 4 0.26 -0.88 1.29 1587.21 1.00 623 123 12 4 FALSE 0.20
non-small cell lung cancer KRAS_12C PIK3CG Any mutation 225 150 TMB quintile 5 -0.10 -0.57 0.34 1463.93 1.00 891 200 125 25 FALSE 0.18
non-small cell lung cancer KRAS_12C PIK3CG Any mutation 352 166 TMB overall 0.06 -2.03 2.24 1438.00 1.00 1514 323 137 29 FALSE 0.02
non-small cell lung cancer KRAS_12C EGFR Any mutation 27 200 TMB quintile 2 -4.08 -6.61 -2.44 1406.37 1.00 236 27 200 0 TRUE 3.79
non-small cell lung cancer KRAS_12C EGFR Any mutation 46 287 TMB quintile 3 -4.24 -6.82 -2.61 1381.78 1.00 350 46 287 0 TRUE 4.20
non-small cell lung cancer KRAS_12C EGFR Any mutation 127 256 TMB quintile 4 -4.00 -5.75 -2.74 1408.21 1.00 444 126 255 1 TRUE 6.50
non-small cell lung cancer KRAS_12C EGFR Any mutation 222 175 TMB quintile 5 -2.03 -2.93 -1.24 1349.11 1.00 874 214 167 8 TRUE 5.48
non-small cell lung cancer KRAS_12C EGFR Any mutation 422 918 TMB overall -3.54 -5.25 -2.19 1372.10 1.00 1904 413 909 9 TRUE 5.44
non-small cell lung cancer KRAS_12C ARID1B Any mutation 46 11 TMB quintile 3 0.30 -1.11 1.61 1477.34 1.00 571 44 9 2 TRUE 0.18
non-small cell lung cancer KRAS_12C ARID1B Any mutation 127 16 TMB quintile 4 -0.29 -1.58 0.71 1482.33 1.00 622 125 14 2 TRUE 0.21
non-small cell lung cancer KRAS_12C ARID1B Any mutation 223 77 TMB quintile 5 -0.17 -0.83 0.42 1320.55 1.00 940 211 65 12 TRUE 0.22
non-small cell lung cancer KRAS_12C ARID1B Any mutation 396 104 TMB overall -0.06 -1.30 1.14 1560.63 1.00 2133 380 88 16 TRUE 0.04
non-small cell lung cancer KRAS_12C MET Any mutation 27 21 TMB quintile 2 -1.43 -3.19 -0.10 1471.90 1.00 394 27 21 0 TRUE 1.12
non-small cell lung cancer KRAS_12C MET Any mutation 46 30 TMB quintile 3 -1.20 -2.64 0.05 1317.66 1.00 557 45 29 1 TRUE 1.11
non-small cell lung cancer KRAS_12C MET Any mutation 127 34 TMB quintile 4 -1.76 -3.71 -0.57 1416.41 1.00 607 127 34 0 TRUE 1.50
non-small cell lung cancer KRAS_12C MET Any mutation 222 47 TMB quintile 5 -0.65 -1.59 0.15 1586.75 1.00 963 215 40 7 TRUE 0.86
non-small cell lung cancer KRAS_12C MET Any mutation 422 132 TMB overall -1.24 -2.44 -0.22 1420.52 1.00 2521 414 124 8 TRUE 1.51
non-small cell lung cancer KRAS_12C BRAF Any mutation 27 11 TMB quintile 2 -1.80 -3.79 0.00 1543.12 1.00 403 27 11 0 TRUE 1.19
non-small cell lung cancer KRAS_12C BRAF Any mutation 46 13 TMB quintile 3 -1.81 -3.82 -0.11 1595.41 1.00 567 46 13 0 TRUE 1.27
non-small cell lung cancer KRAS_12C BRAF Any mutation 127 46 TMB quintile 4 -1.69 -3.00 -0.57 1266.29 1.00 592 125 44 2 TRUE 2.13
non-small cell lung cancer KRAS_12C BRAF Any mutation 222 101 TMB quintile 5 -1.43 -2.33 -0.67 1430.58 1.00 908 216 95 6 TRUE 3.25
non-small cell lung cancer KRAS_12C BRAF Any mutation 422 171 TMB overall -1.69 -3.05 -0.50 1420.81 1.00 2470 414 163 8 TRUE 2.09
non-small cell lung cancer KRAS_12C CARD11 Any mutation 127 18 TMB quintile 4 0.64 -0.34 1.62 1468.64 1.00 623 121 12 6 FALSE 0.69
non-small cell lung cancer KRAS_12C CARD11 Any mutation 223 97 TMB quintile 5 -0.08 -0.64 0.45 1491.27 1.00 925 207 81 16 FALSE 0.10
non-small cell lung cancer KRAS_12C CARD11 Any mutation 350 115 TMB overall 0.22 -1.57 1.98 1598.92 1.00 1548 328 93 22 FALSE 0.10
non-small cell lung cancer KRAS_12C INPP4B Any mutation 127 17 TMB quintile 4 -0.26 -1.71 0.77 1253.11 1.00 620 125 15 2 FALSE 0.17
non-small cell lung cancer KRAS_12C INPP4B Any mutation 224 87 TMB quintile 5 0.55 0.06 1.05 1653.69 1.00 945 200 63 24 FALSE 1.53
non-small cell lung cancer KRAS_12C INPP4B Any mutation 351 104 TMB overall 0.14 -1.63 2.03 1411.29 1.00 1565 325 78 26 FALSE 0.06
non-small cell lung cancer KRAS_12C NFE2L2 Any mutation 127 31 TMB quintile 4 -0.91 -2.04 -0.01 1144.29 1.00 612 125 29 2 FALSE 1.18
non-small cell lung cancer KRAS_12C NFE2L2 Any mutation 223 83 TMB quintile 5 -0.73 -1.45 -0.07 1289.54 1.00 933 214 74 9 FALSE 1.49
non-small cell lung cancer KRAS_12C NFE2L2 Any mutation 350 114 TMB overall -0.79 -1.98 0.23 1170.89 1.00 1545 339 103 11 FALSE 0.77
non-small cell lung cancer KRAS_12C GLI1 Any mutation 121 16 TMB quintile 4 0.50 -0.45 1.44 1436.48 1.00 550 116 11 5 FALSE 0.52
non-small cell lung cancer KRAS_12C GLI1 Any mutation 204 77 TMB quintile 5 0.29 -0.29 0.85 1469.82 1.00 843 187 60 17 FALSE 0.50
non-small cell lung cancer KRAS_12C GLI1 Any mutation 325 93 TMB overall 0.40 -1.06 1.89 1571.33 1.00 1393 303 71 22 FALSE 0.22
non-small cell lung cancer KRAS_12C ZFHX3 Any mutation 43 13 TMB quintile 3 -0.98 -3.06 0.55 1347.80 1.00 514 43 13 0 FALSE 0.52
non-small cell lung cancer KRAS_12C ZFHX3 Any mutation 121 30 TMB quintile 4 -0.10 -0.98 0.76 1577.38 1.00 534 115 24 6 FALSE 0.09
non-small cell lung cancer KRAS_12C ZFHX3 Any mutation 203 112 TMB quintile 5 -0.57 -1.17 -0.01 1533.52 1.00 807 190 99 13 FALSE 1.24
non-small cell lung cancer KRAS_12C ZFHX3 Any mutation 367 155 TMB overall -0.55 -1.93 0.61 1387.69 1.00 1855 348 136 19 FALSE 0.41
non-small cell lung cancer KRAS_12C MGA Any mutation 43 14 TMB quintile 3 -0.03 -1.65 1.21 1223.00 1.00 515 42 13 1 FALSE 0.02
non-small cell lung cancer KRAS_12C MGA Any mutation 121 24 TMB quintile 4 0.30 -0.55 1.14 1579.80 1.00 540 115 18 6 FALSE 0.30
non-small cell lung cancer KRAS_12C MGA Any mutation 206 140 TMB quintile 5 0.23 -0.20 0.64 1582.53 1.00 804 176 110 30 FALSE 0.54
non-small cell lung cancer KRAS_12C MGA Any mutation 370 178 TMB overall 0.16 -1.08 1.29 1338.13 1.00 1859 333 141 37 FALSE 0.10
non-small cell lung cancer KRAS_12C PREX2 Any mutation 68 14 TMB quintile 4 0.27 -0.83 1.36 1590.81 1.00 281 64 10 4 FALSE 0.20
non-small cell lung cancer KRAS_12C PREX2 Any mutation 121 84 TMB quintile 5 -0.08 -0.69 0.48 1488.36 1.00 438 106 69 15 FALSE 0.10
non-small cell lung cancer KRAS_12C PREX2 Any mutation 189 98 TMB overall 0.10 -1.45 1.88 1698.35 1.00 719 170 79 19 FALSE 0.04
non-small cell lung cancer KRAS_12C AMER1 Any mutation 127 18 TMB quintile 4 1.52 0.58 2.49 1472.18 1.00 626 118 9 9 FALSE 2.80
non-small cell lung cancer KRAS_12C AMER1 Any mutation 224 107 TMB quintile 5 0.27 -0.22 0.75 1484.54 1.00 927 200 83 24 FALSE 0.56
non-small cell lung cancer KRAS_12C AMER1 Any mutation 351 142 TMB overall 0.30 -2.90 3.20 1507.03 1.00 1563 318 109 33 FALSE 0.07
non-small cell lung cancer KRAS_12C EPHA7 Any mutation 121 14 TMB quintile 4 0.30 -0.82 1.42 1403.73 1.00 547 117 10 4 FALSE 0.22
non-small cell lung cancer KRAS_12C EPHA7 Any mutation 202 101 TMB quintile 5 -0.24 -0.85 0.28 1584.89 1.00 822 187 86 15 FALSE 0.40
non-small cell lung cancer KRAS_12C EPHA7 Any mutation 323 115 TMB overall 0.03 -1.73 1.87 1550.76 1.00 1369 304 96 19 FALSE 0.01
colorectal cancer RAS_13 SPEN Any mutation 62 11 TMB quintile 4 -2.31 -6.77 0.43 1524.81 1.00 718 62 11 0 FALSE 0.68
colorectal cancer RAS_13 SPEN Any mutation 80 31 TMB quintile 5 -1.02 -2.84 0.30 1297.49 1.00 521 78 29 2 FALSE 0.71
colorectal cancer RAS_13 SPEN Any mutation 18 107 TMB quintile 6 -0.97 -1.90 -0.07 1604.08 1.00 61 11 100 7 FALSE 1.36
colorectal cancer RAS_13 SPEN Any mutation 160 149 TMB overall -1.35 -4.10 1.07 1504.04 1.00 1300 151 140 9 FALSE 0.53
colorectal cancer RAS_13 KMT2C Any mutation 61 12 TMB quintile 4 -0.32 -2.40 1.38 1235.46 1.00 701 60 11 1 FALSE 0.13
colorectal cancer RAS_13 KMT2C Any mutation 77 61 TMB quintile 5 0.11 -0.67 0.84 1656.28 1.00 467 68 52 9 FALSE 0.11
colorectal cancer RAS_13 KMT2C Any mutation 20 116 TMB quintile 6 -0.47 -1.40 0.41 1465.87 1.00 62 10 106 10 FALSE 0.50
colorectal cancer RAS_13 KMT2C Any mutation 158 189 TMB overall -0.21 -2.35 1.90 1232.32 1.00 1230 138 169 20 FALSE 0.07
colorectal cancer RAS_13 TP53 Any mutation 10 104 TMB quintile 2 -0.58 -1.44 0.24 1355.94 1.00 30 4 98 6 TRUE 0.76
colorectal cancer RAS_13 TP53 Any mutation 25 411 TMB quintile 3 -0.86 -1.58 -0.21 1519.28 1.00 76 9 395 16 TRUE 1.87
colorectal cancer RAS_13 TP53 Any mutation 64 655 TMB quintile 4 -0.28 -0.76 0.25 1455.51 1.00 159 16 607 48 TRUE 0.57
colorectal cancer RAS_13 TP53 Any mutation 84 423 TMB quintile 5 -0.29 -0.72 0.12 1158.70 1.00 213 36 375 48 TRUE 0.73
colorectal cancer RAS_13 TP53 Any mutation 20 78 TMB quintile 6 -0.12 -0.86 0.65 1172.30 1.00 82 10 68 10 TRUE 0.12
colorectal cancer RAS_13 TP53 Any mutation 203 1671 TMB overall -0.42 -1.02 0.23 1610.91 1.00 560 75 1543 128 TRUE 0.75
colorectal cancer RAS_13 ATRX Any mutation 62 19 TMB quintile 4 -1.79 -5.00 0.24 1357.95 1.00 710 62 19 0 TRUE 0.76
colorectal cancer RAS_13 ATRX Any mutation 80 35 TMB quintile 5 -1.03 -2.58 0.18 1412.05 1.00 515 78 33 2 TRUE 0.82
colorectal cancer RAS_13 ATRX Any mutation 21 59 TMB quintile 6 0.16 -0.77 1.07 1453.71 1.00 89 12 50 9 TRUE 0.14
colorectal cancer RAS_13 ATRX Any mutation 163 113 TMB overall -0.87 -3.01 0.94 1514.99 1.00 1314 152 102 11 TRUE 0.41
colorectal cancer RAS_13 ATR Any mutation 81 35 TMB quintile 5 0.61 -0.28 1.43 1509.24 1.00 519 73 27 8 FALSE 0.79
colorectal cancer RAS_13 ATR Any mutation 18 65 TMB quintile 6 -1.10 -2.58 0.06 1493.11 1.00 91 15 62 3 FALSE 1.05
colorectal cancer RAS_13 ATR Any mutation 99 100 TMB overall -0.23 -2.65 2.41 1429.68 1.00 610 88 89 11 FALSE 0.07
colorectal cancer RAS_13 FBXW7 Any mutation 25 22 TMB quintile 3 -0.48 -2.47 0.89 1342.82 1.00 441 25 22 0 TRUE 0.24
colorectal cancer RAS_13 FBXW7 Any mutation 64 85 TMB quintile 4 0.46 -0.24 1.10 1259.78 1.00 663 54 75 10 TRUE 0.75
colorectal cancer RAS_13 FBXW7 Any mutation 83 160 TMB quintile 5 0.40 -0.10 0.89 1371.69 1.00 433 57 134 26 TRUE 0.96
colorectal cancer RAS_13 FBXW7 Any mutation 17 65 TMB quintile 6 1.30 0.37 2.35 1385.79 1.00 80 4 52 13 TRUE 1.97
colorectal cancer RAS_13 FBXW7 Any mutation 189 332 TMB overall 0.41 -0.73 1.49 1514.51 1.00 1617 140 283 49 TRUE 0.34
colorectal cancer RAS_13 FLT4 Any mutation 62 20 TMB quintile 4 -0.09 -1.71 1.21 1467.57 1.00 711 60 18 2 TRUE 0.04
colorectal cancer RAS_13 FLT4 Any mutation 80 40 TMB quintile 5 -0.38 -1.52 0.54 1510.69 1.00 514 76 36 4 TRUE 0.32
colorectal cancer RAS_13 FLT4 Any mutation 16 72 TMB quintile 6 -0.66 -1.83 0.34 1362.87 1.00 72 11 67 5 TRUE 0.64
colorectal cancer RAS_13 FLT4 Any mutation 158 132 TMB overall -0.40 -2.21 1.48 1342.23 1.00 1297 147 121 11 TRUE 0.18
colorectal cancer RAS_13 PTPRD Any mutation 80 29 TMB quintile 5 -0.41 -1.73 0.69 1538.32 1.00 522 77 26 3 FALSE 0.29
colorectal cancer RAS_13 PTPRD Any mutation 17 61 TMB quintile 6 -0.46 -1.61 0.57 1565.14 1.00 87 12 56 5 FALSE 0.39
colorectal cancer RAS_13 PTPRD Any mutation 97 90 TMB overall -0.41 -2.64 1.86 1588.34 1.00 609 89 82 8 FALSE 0.15
colorectal cancer RAS_13 CREBBP Any mutation 62 17 TMB quintile 4 -0.57 -2.64 0.97 1440.84 1.00 713 61 16 1 TRUE 0.27
colorectal cancer RAS_13 CREBBP Any mutation 80 49 TMB quintile 5 0.22 -0.61 1.00 1543.10 1.00 512 72 41 8 TRUE 0.23
colorectal cancer RAS_13 CREBBP Any mutation 19 116 TMB quintile 6 -0.71 -1.62 0.19 1394.33 1.00 54 10 107 9 TRUE 0.88
colorectal cancer RAS_13 CREBBP Any mutation 161 182 TMB overall -0.34 -2.37 1.75 1274.97 1.00 1279 143 164 18 TRUE 0.13
colorectal cancer RAS_13 AXIN2 Any mutation 62 20 TMB quintile 4 -0.51 -2.45 0.92 1501.23 1.00 710 61 19 1 TRUE 0.26
colorectal cancer RAS_13 AXIN2 Any mutation 80 27 TMB quintile 5 0.04 -1.07 1.10 1521.22 1.00 524 76 23 4 TRUE 0.03
colorectal cancer RAS_13 AXIN2 Any mutation 17 63 TMB quintile 6 0.29 -0.64 1.26 1568.44 1.00 86 9 55 8 TRUE 0.26
colorectal cancer RAS_13 AXIN2 Any mutation 159 110 TMB overall -0.05 -1.80 1.70 1510.37 1.00 1320 146 97 13 TRUE 0.02
colorectal cancer RAS_13 PTPRS Any mutation 25 17 TMB quintile 3 -1.17 -3.90 0.89 1491.18 1.00 440 25 17 0 FALSE 0.46
colorectal cancer RAS_13 PTPRS Any mutation 61 34 TMB quintile 4 0.56 -0.47 1.48 1491.81 1.00 683 56 29 5 FALSE 0.58
colorectal cancer RAS_13 PTPRS Any mutation 78 74 TMB quintile 5 -0.28 -1.08 0.44 1543.72 1.00 456 70 66 8 FALSE 0.32
colorectal cancer RAS_13 PTPRS Any mutation 18 128 TMB quintile 6 0.34 -0.67 1.43 1499.56 1.00 45 4 114 14 FALSE 0.27
colorectal cancer RAS_13 PTPRS Any mutation 182 253 TMB overall -0.18 -2.06 1.42 1517.88 1.00 1624 155 226 27 FALSE 0.08
colorectal cancer RAS_13 SMARCA4 Any mutation 62 16 TMB quintile 4 -2.01 -5.99 0.28 1447.37 1.00 713 62 16 0 FALSE 0.65
colorectal cancer RAS_13 SMARCA4 Any mutation 80 47 TMB quintile 5 -0.62 -1.77 0.30 1477.16 1.00 507 76 43 4 FALSE 0.59
colorectal cancer RAS_13 SMARCA4 Any mutation 18 100 TMB quintile 6 -0.13 -1.02 0.85 1300.48 1.00 67 8 90 10 FALSE 0.10
colorectal cancer RAS_13 SMARCA4 Any mutation 160 163 TMB overall -0.87 -3.23 1.20 1428.94 1.00 1287 146 149 14 FALSE 0.36
colorectal cancer RAS_13 PTPRT Any mutation 25 18 TMB quintile 3 0.43 -1.04 1.70 1618.32 1.00 446 23 16 2 FALSE 0.27
colorectal cancer RAS_13 PTPRT Any mutation 62 39 TMB quintile 4 -0.33 -1.63 0.69 1573.44 1.00 692 60 37 2 FALSE 0.24
colorectal cancer RAS_13 PTPRT Any mutation 80 59 TMB quintile 5 -0.08 -0.92 0.65 1583.73 1.00 497 73 52 7 FALSE 0.07
colorectal cancer RAS_13 PTPRT Any mutation 20 66 TMB quintile 6 0.78 -0.04 1.68 1619.53 1.00 85 8 54 12 FALSE 1.11
colorectal cancer RAS_13 PTPRT Any mutation 187 182 TMB overall 0.20 -0.96 1.31 1504.57 1.00 1720 164 159 23 FALSE 0.13
colorectal cancer RAS_13 PIK3CA Any mutation 25 51 TMB quintile 3 0.69 -0.24 1.54 1564.61 1.00 419 20 46 5 TRUE 0.90
colorectal cancer RAS_13 PIK3CA Any mutation 62 146 TMB quintile 4 0.16 -0.44 0.76 1617.90 1.00 601 50 134 12 TRUE 0.21
colorectal cancer RAS_13 PIK3CA Any mutation 87 209 TMB quintile 5 0.70 0.25 1.14 1756.19 1.00 392 47 169 40 TRUE 2.62
colorectal cancer RAS_13 PIK3CA Any mutation 20 95 TMB quintile 6 1.05 0.17 1.97 1576.73 1.00 68 4 79 16 TRUE 1.77
colorectal cancer RAS_13 PIK3CA Any mutation 194 501 TMB overall 0.66 -0.23 1.56 1424.32 1.00 1480 121 428 73 TRUE 0.82
colorectal cancer RAS_13 ALK Any mutation 62 20 TMB quintile 4 1.13 0.07 2.07 1522.16 1.00 714 57 15 5 TRUE 1.55
colorectal cancer RAS_13 ALK Any mutation 80 42 TMB quintile 5 0.65 -0.14 1.38 1526.40 1.00 515 71 33 9 TRUE 1.03
colorectal cancer RAS_13 ALK Any mutation 19 45 TMB quintile 6 0.30 -0.73 1.21 1505.73 1.00 97 13 39 6 TRUE 0.27
colorectal cancer RAS_13 ALK Any mutation 161 107 TMB overall 0.70 -0.74 2.12 1428.69 1.00 1326 141 87 20 TRUE 0.49
colorectal cancer RAS_13 RNF43 Any mutation 25 12 TMB quintile 3 -1.42 -4.85 0.96 1177.72 1.00 450 25 12 0 TRUE 0.46
colorectal cancer RAS_13 RNF43 Any mutation 62 30 TMB quintile 4 -0.47 -2.06 0.81 1255.39 1.00 702 60 28 2 TRUE 0.28
colorectal cancer RAS_13 RNF43 Any mutation 80 76 TMB quintile 5 -0.61 -1.56 0.17 1411.14 1.00 490 74 70 6 TRUE 0.78
colorectal cancer RAS_13 RNF43 Any mutation 22 146 TMB quintile 6 -0.09 -0.99 0.91 1294.63 1.00 43 6 130 16 TRUE 0.06
colorectal cancer RAS_13 RNF43 Any mutation 189 264 TMB overall -0.61 -2.31 1.12 1486.04 1.00 1685 165 240 24 TRUE 0.32
colorectal cancer RAS_13 PTEN Any mutation 62 29 TMB quintile 4 0.51 -0.60 1.42 1475.02 1.00 705 58 25 4 TRUE 0.49
colorectal cancer RAS_13 PTEN Any mutation 82 69 TMB quintile 5 0.39 -0.30 1.05 1248.97 1.00 503 70 57 12 TRUE 0.61
colorectal cancer RAS_13 PTEN Any mutation 21 80 TMB quintile 6 0.51 -0.37 1.38 1463.08 1.00 81 9 68 12 TRUE 0.60
colorectal cancer RAS_13 PTEN Any mutation 165 178 TMB overall 0.47 -1.03 1.83 1413.98 1.00 1289 137 150 28 TRUE 0.28
colorectal cancer RAS_13 BCOR Any mutation 62 11 TMB quintile 4 -0.28 -2.35 1.32 1488.90 1.00 719 61 10 1 FALSE 0.12
colorectal cancer RAS_13 BCOR Any mutation 80 39 TMB quintile 5 -0.98 -2.55 0.22 1408.56 1.00 512 78 37 2 FALSE 0.79
colorectal cancer RAS_13 BCOR Any mutation 18 57 TMB quintile 6 0.30 -0.72 1.27 1254.27 1.00 89 10 49 8 FALSE 0.26
colorectal cancer RAS_13 BCOR Any mutation 160 107 TMB overall -0.31 -2.23 1.65 1165.49 1.00 1320 149 96 11 FALSE 0.12
colorectal cancer RAS_13 CTNNB1 Any mutation 25 38 TMB quintile 3 0.42 -0.61 1.32 1596.24 1.00 429 22 35 3 TRUE 0.40
colorectal cancer RAS_13 CTNNB1 Any mutation 62 35 TMB quintile 4 0.40 -0.50 1.25 1497.84 1.00 699 58 31 4 TRUE 0.43
colorectal cancer RAS_13 CTNNB1 Any mutation 80 48 TMB quintile 5 0.26 -0.51 0.96 1400.16 1.00 507 73 41 7 TRUE 0.31
colorectal cancer RAS_13 CTNNB1 Any mutation 16 35 TMB quintile 6 0.84 -0.05 1.75 1653.39 1.00 99 9 28 7 TRUE 1.16
colorectal cancer RAS_13 CTNNB1 Any mutation 183 156 TMB overall 0.48 -0.41 1.42 1536.31 1.00 1734 162 135 21 TRUE 0.54
colorectal cancer RAS_13 ARID1A Any mutation 62 32 TMB quintile 4 -2.39 -6.34 -0.09 1550.39 1.00 698 62 32 0 TRUE 0.82
colorectal cancer RAS_13 ARID1A Any mutation 82 116 TMB quintile 5 -0.42 -1.14 0.24 1813.30 1.00 467 71 105 11 TRUE 0.66
colorectal cancer RAS_13 ARID1A Any mutation 22 155 TMB quintile 6 0.13 -0.83 1.11 1409.69 1.00 48 5 138 17 TRUE 0.10
colorectal cancer RAS_13 ARID1A Any mutation 166 303 TMB overall -0.84 -3.26 1.26 1484.59 1.00 1213 138 275 28 TRUE 0.32
colorectal cancer RAS_13 PIK3R1 Any mutation 62 22 TMB quintile 4 -0.70 -2.51 0.68 1398.54 1.00 709 61 21 1 TRUE 0.39
colorectal cancer RAS_13 PIK3R1 Any mutation 80 29 TMB quintile 5 -0.73 -2.13 0.42 1460.74 1.00 522 78 27 2 TRUE 0.58
colorectal cancer RAS_13 PIK3R1 Any mutation 17 56 TMB quintile 6 0.16 -0.83 1.17 1460.80 1.00 90 10 49 7 TRUE 0.12
colorectal cancer RAS_13 PIK3R1 Any mutation 159 107 TMB overall -0.42 -2.20 1.25 1645.27 1.00 1321 149 97 10 TRUE 0.21
colorectal cancer RAS_13 FAT1 Any mutation 62 17 TMB quintile 4 -0.50 -2.65 1.07 1447.43 1.00 714 61 16 1 FALSE 0.22
colorectal cancer RAS_13 FAT1 Any mutation 80 64 TMB quintile 5 -0.39 -1.34 0.42 1642.86 1.00 497 74 58 6 FALSE 0.41
colorectal cancer RAS_13 FAT1 Any mutation 29 145 TMB quintile 6 0.83 -0.08 1.81 1530.35 1.00 58 5 121 24 FALSE 1.09
colorectal cancer RAS_13 FAT1 Any mutation 171 226 TMB overall -0.02 -2.15 2.13 1605.30 1.00 1269 140 195 31 FALSE 0.01
colorectal cancer RAS_13 CIC Any mutation 62 17 TMB quintile 4 0.00 -1.72 1.44 1469.15 1.00 715 60 15 2 TRUE 0.00
colorectal cancer RAS_13 CIC Any mutation 81 40 TMB quintile 5 -0.71 -2.02 0.32 1610.28 1.00 513 78 37 3 TRUE 0.64
colorectal cancer RAS_13 CIC Any mutation 17 79 TMB quintile 6 -0.81 -1.92 0.21 1529.59 1.00 74 12 74 5 TRUE 0.88
colorectal cancer RAS_13 CIC Any mutation 160 136 TMB overall -0.49 -2.27 1.36 1396.73 1.00 1302 150 126 10 TRUE 0.23
colorectal cancer RAS_13 NCOR1 Any mutation 62 16 TMB quintile 4 0.19 -1.53 1.51 1311.77 1.00 715 60 14 2 FALSE 0.09
colorectal cancer RAS_13 NCOR1 Any mutation 80 32 TMB quintile 5 -0.40 -1.69 0.62 1475.03 1.00 523 77 29 3 FALSE 0.30
colorectal cancer RAS_13 NCOR1 Any mutation 18 81 TMB quintile 6 0.03 -0.96 0.91 1498.78 1.00 72 9 72 9 FALSE 0.02
colorectal cancer RAS_13 NCOR1 Any mutation 160 129 TMB overall -0.06 -2.04 1.83 1519.32 1.00 1310 146 115 14 FALSE 0.02
colorectal cancer RAS_13 POLE Any mutation 80 38 TMB quintile 5 -0.32 -1.53 0.67 1403.32 1.00 514 76 34 4 TRUE 0.25
colorectal cancer RAS_13 POLE Any mutation 20 93 TMB quintile 6 0.42 -0.51 1.31 1322.68 1.00 68 7 80 13 TRUE 0.43
colorectal cancer RAS_13 POLE Any mutation 100 131 TMB overall 0.04 -2.73 2.69 1548.11 1.00 582 83 114 17 TRUE 0.01
colorectal cancer RAS_13 TGFBR2 Any mutation 80 47 TMB quintile 5 0.12 -0.73 0.91 1542.51 1.00 511 73 40 7 TRUE 0.11
colorectal cancer RAS_13 TGFBR2 Any mutation 16 57 TMB quintile 6 -0.12 -1.18 0.88 1391.11 1.00 76 10 51 6 TRUE 0.08
colorectal cancer RAS_13 TGFBR2 Any mutation 96 104 TMB overall 0.06 -2.12 2.43 1616.66 1.00 587 83 91 13 TRUE 0.02
colorectal cancer RAS_13 KMT2A Any mutation 62 16 TMB quintile 4 -1.69 -5.76 0.47 1551.80 1.00 713 62 16 0 FALSE 0.56
colorectal cancer RAS_13 KMT2A Any mutation 81 43 TMB quintile 5 0.19 -0.70 1.03 1255.61 1.00 513 74 36 7 FALSE 0.17
colorectal cancer RAS_13 KMT2A Any mutation 21 84 TMB quintile 6 0.14 -0.69 1.08 1411.48 1.00 78 10 73 11 FALSE 0.12
colorectal cancer RAS_13 KMT2A Any mutation 164 143 TMB overall -0.46 -3.03 1.49 1545.21 1.00 1304 146 125 18 FALSE 0.16
colorectal cancer RAS_13 BRCA2 Any mutation 62 21 TMB quintile 4 0.44 -0.84 1.57 1444.65 1.00 711 59 18 3 TRUE 0.31
colorectal cancer RAS_13 BRCA2 Any mutation 82 48 TMB quintile 5 0.09 -0.82 0.91 1496.86 1.00 511 75 41 7 TRUE 0.08
colorectal cancer RAS_13 BRCA2 Any mutation 23 116 TMB quintile 6 -0.24 -1.11 0.61 1630.59 1.00 70 11 104 12 TRUE 0.23
colorectal cancer RAS_13 BRCA2 Any mutation 167 185 TMB overall 0.10 -1.75 2.01 1409.10 1.00 1292 145 163 22 TRUE 0.04
colorectal cancer RAS_13 NOTCH3 Any mutation 25 12 TMB quintile 3 0.13 -1.98 1.79 1569.31 1.00 451 24 11 1 TRUE 0.05
colorectal cancer RAS_13 NOTCH3 Any mutation 62 17 TMB quintile 4 0.18 -1.31 1.47 1377.67 1.00 714 60 15 2 TRUE 0.09
colorectal cancer RAS_13 NOTCH3 Any mutation 80 50 TMB quintile 5 0.26 -0.54 1.00 1301.99 1.00 509 72 42 8 TRUE 0.29
colorectal cancer RAS_13 NOTCH3 Any mutation 17 120 TMB quintile 6 -0.03 -1.01 1.02 1340.85 1.00 53 6 109 11 TRUE 0.02
colorectal cancer RAS_13 NOTCH3 Any mutation 184 199 TMB overall 0.11 -1.50 1.70 1551.94 1.00 1727 162 177 22 TRUE 0.05
colorectal cancer RAS_13 NOTCH4 Any mutation 61 21 TMB quintile 4 0.26 -1.26 1.48 1402.18 1.00 695 58 18 3 TRUE 0.15
colorectal cancer RAS_13 NOTCH4 Any mutation 77 37 TMB quintile 5 -2.52 -5.80 -0.58 1482.31 1.00 476 77 37 0 TRUE 1.15
colorectal cancer RAS_13 NOTCH4 Any mutation 19 59 TMB quintile 6 -0.18 -1.22 0.74 1606.04 1.00 81 12 52 7 TRUE 0.14
colorectal cancer RAS_13 NOTCH4 Any mutation 157 117 TMB overall -0.77 -2.90 1.25 1644.02 1.00 1252 147 107 10 TRUE 0.33
colorectal cancer RAS_13 ERBB3 Any mutation 62 27 TMB quintile 4 -1.38 -4.37 0.45 1372.59 1.00 703 62 27 0 TRUE 0.59
colorectal cancer RAS_13 ERBB3 Any mutation 80 39 TMB quintile 5 0.33 -0.56 1.18 1405.38 1.00 515 73 32 7 TRUE 0.34
colorectal cancer RAS_13 ERBB3 Any mutation 18 51 TMB quintile 6 0.90 -0.03 1.86 1362.00 1.00 94 8 41 10 TRUE 1.18
colorectal cancer RAS_13 ERBB3 Any mutation 160 117 TMB overall -0.07 -2.00 1.62 1437.23 1.00 1312 143 100 17 TRUE 0.03
colorectal cancer RAS_13 SMAD4 Any mutation 25 51 TMB quintile 3 -0.40 -1.32 0.53 1052.11 1.00 416 22 48 3 TRUE 0.41
colorectal cancer RAS_13 SMAD4 Any mutation 62 129 TMB quintile 4 -0.83 -1.61 -0.12 1355.28 1.00 610 58 125 4 TRUE 1.49
colorectal cancer RAS_13 SMAD4 Any mutation 82 138 TMB quintile 5 -0.47 -1.01 0.09 1634.38 1.00 436 69 125 13 TRUE 1.00
colorectal cancer RAS_13 SMAD4 Any mutation 16 31 TMB quintile 6 -0.60 -1.55 0.35 1624.74 1.00 103 14 29 2 TRUE 0.67
colorectal cancer RAS_13 SMAD4 Any mutation 185 349 TMB overall -0.58 -1.30 0.10 1763.95 1.00 1565 163 327 22 TRUE 0.94
colorectal cancer RAS_13 ATM Any mutation 63 46 TMB quintile 4 0.25 -0.72 1.13 1619.76 1.00 692 58 41 5 TRUE 0.23
colorectal cancer RAS_13 ATM Any mutation 81 78 TMB quintile 5 -0.13 -0.90 0.53 1382.18 1.00 485 72 69 9 TRUE 0.14
colorectal cancer RAS_13 ATM Any mutation 21 94 TMB quintile 6 0.45 -0.45 1.38 1739.83 1.00 79 8 81 13 TRUE 0.52
colorectal cancer RAS_13 ATM Any mutation 165 218 TMB overall 0.20 -1.27 1.65 1522.64 1.00 1256 138 191 27 TRUE 0.11
colorectal cancer RAS_13 KMT2D Any mutation 62 27 TMB quintile 4 -1.06 -3.14 0.53 1423.63 1.00 704 61 26 1 FALSE 0.54
colorectal cancer RAS_13 KMT2D Any mutation 80 104 TMB quintile 5 -0.49 -1.29 0.22 1427.92 1.00 480 71 95 9 FALSE 0.69
colorectal cancer RAS_13 KMT2D Any mutation 28 245 TMB quintile 6 -0.35 -1.52 1.02 1406.39 1.00 16 3 220 25 FALSE 0.23
colorectal cancer RAS_13 KMT2D Any mutation 170 376 TMB overall -0.63 -3.20 1.89 1521.51 1.00 1200 135 341 35 FALSE 0.21
colorectal cancer RAS_13 TSC2 Any mutation 80 42 TMB quintile 5 -0.47 -1.64 0.52 1471.75 1.00 515 76 38 4 TRUE 0.41
colorectal cancer RAS_13 TSC2 Any mutation 17 56 TMB quintile 6 -0.43 -1.61 0.59 1490.18 1.00 86 12 51 5 TRUE 0.36
colorectal cancer RAS_13 TSC2 Any mutation 97 98 TMB overall -0.39 -2.48 1.89 1522.29 1.00 601 88 89 9 TRUE 0.14
colorectal cancer RAS_13 APC Any mutation 10 78 TMB quintile 2 -0.01 -1.00 0.88 1324.84 1.00 63 5 73 5 TRUE 0.01
colorectal cancer RAS_13 APC Any mutation 26 428 TMB quintile 3 -0.56 -1.26 0.15 1498.19 1.00 146 12 414 14 TRUE 0.92
colorectal cancer RAS_13 APC Any mutation 90 966 TMB quintile 4 0.32 -0.26 0.89 1466.17 1.00 143 9 885 81 TRUE 0.57
colorectal cancer RAS_13 APC Any mutation 139 822 TMB quintile 5 0.90 0.35 1.50 1479.22 1.00 142 9 692 130 TRUE 2.64
colorectal cancer RAS_13 APC Any mutation 33 225 TMB quintile 6 0.33 -0.38 1.06 1279.59 1.00 42 5 197 28 TRUE 0.42
colorectal cancer RAS_13 APC Any mutation 298 2519 TMB overall 0.20 -0.55 0.92 1361.14 1.00 536 40 2261 258 TRUE 0.24
colorectal cancer RAS_13 ERBB2 Any mutation 62 17 TMB quintile 4 0.31 -1.14 1.49 1467.50 1.00 714 60 15 2 TRUE 0.19
colorectal cancer RAS_13 ERBB2 Any mutation 80 33 TMB quintile 5 0.56 -0.32 1.39 1470.87 1.00 520 73 26 7 TRUE 0.68
colorectal cancer RAS_13 ERBB2 Any mutation 17 42 TMB quintile 6 0.42 -0.63 1.36 1457.84 1.00 97 11 36 6 TRUE 0.39
colorectal cancer RAS_13 ERBB2 Any mutation 159 92 TMB overall 0.44 -1.02 1.91 1319.20 1.00 1331 144 77 15 TRUE 0.26
colorectal cancer RAS_13 ARID2 Any mutation 62 12 TMB quintile 4 0.37 -1.48 1.81 1434.93 1.00 719 60 10 2 FALSE 0.19
colorectal cancer RAS_13 ARID2 Any mutation 80 31 TMB quintile 5 -0.79 -2.41 0.40 1364.86 1.00 519 78 29 2 FALSE 0.59
colorectal cancer RAS_13 ARID2 Any mutation 17 66 TMB quintile 6 -0.33 -1.37 0.60 1582.86 1.00 77 11 60 6 FALSE 0.29
colorectal cancer RAS_13 ARID2 Any mutation 159 109 TMB overall -0.25 -2.12 1.53 1480.04 1.00 1315 149 99 10 FALSE 0.10
colorectal cancer RAS_13 MTOR Any mutation 62 19 TMB quintile 4 -0.45 -2.40 1.04 1642.88 1.00 711 61 18 1 TRUE 0.22
colorectal cancer RAS_13 MTOR Any mutation 80 40 TMB quintile 5 0.30 -0.54 1.06 1485.59 1.00 514 73 33 7 TRUE 0.33
colorectal cancer RAS_13 MTOR Any mutation 20 70 TMB quintile 6 0.51 -0.36 1.35 1399.06 1.00 83 9 59 11 TRUE 0.60
colorectal cancer RAS_13 MTOR Any mutation 162 129 TMB overall 0.16 -1.59 1.79 1412.68 1.00 1308 143 110 19 TRUE 0.07
colorectal cancer RAS_13 NOTCH1 Any mutation 81 48 TMB quintile 5 -0.61 -1.71 0.34 1425.92 1.00 505 77 44 4 TRUE 0.61
colorectal cancer RAS_13 NOTCH1 Any mutation 22 112 TMB quintile 6 0.28 -0.63 1.26 1611.20 1.00 60 7 97 15 TRUE 0.25
colorectal cancer RAS_13 NOTCH1 Any mutation 103 160 TMB overall -0.14 -2.82 2.27 1440.85 1.00 565 84 141 19 TRUE 0.04
colorectal cancer RAS_13 SETD2 Any mutation 25 11 TMB quintile 3 -1.02 -4.65 1.03 1350.93 1.00 452 25 11 0 FALSE 0.31
colorectal cancer RAS_13 SETD2 Any mutation 81 31 TMB quintile 5 0.16 -0.94 1.10 1307.82 1.00 522 76 26 5 FALSE 0.12
colorectal cancer RAS_13 SETD2 Any mutation 20 64 TMB quintile 6 0.41 -0.46 1.26 1372.15 1.00 85 10 54 10 FALSE 0.43
colorectal cancer RAS_13 SETD2 Any mutation 126 106 TMB overall -0.14 -2.17 1.66 1405.92 1.00 1059 111 91 15 FALSE 0.05
colorectal cancer RAS_13 EPHA3 Any mutation 62 17 TMB quintile 4 0.17 -1.29 1.40 1487.01 1.00 715 60 15 2 FALSE 0.09
colorectal cancer RAS_13 EPHA3 Any mutation 80 41 TMB quintile 5 -0.08 -1.03 0.78 1441.45 1.00 511 75 36 5 FALSE 0.06
colorectal cancer RAS_13 EPHA3 Any mutation 18 44 TMB quintile 6 0.21 -0.77 1.19 1549.27 1.00 95 12 38 6 FALSE 0.17
colorectal cancer RAS_13 EPHA3 Any mutation 160 102 TMB overall 0.13 -1.29 1.57 1442.04 1.00 1321 147 89 13 FALSE 0.07
colorectal cancer RAS_13 PTCH1 Any mutation 81 35 TMB quintile 5 0.23 -0.77 1.13 1518.97 1.00 518 75 29 6 TRUE 0.20
colorectal cancer RAS_13 PTCH1 Any mutation 23 99 TMB quintile 6 -0.19 -1.07 0.72 1552.17 1.00 63 11 87 12 TRUE 0.17
colorectal cancer RAS_13 PTCH1 Any mutation 104 134 TMB overall -0.05 -2.72 2.53 1579.61 1.00 581 86 116 18 TRUE 0.01
colorectal cancer RAS_13 TET1 Any mutation 77 26 TMB quintile 5 0.10 -1.08 1.14 1654.88 1.00 492 73 22 4 FALSE 0.06
colorectal cancer RAS_13 TET1 Any mutation 22 67 TMB quintile 6 0.41 -0.46 1.29 1567.58 1.00 84 11 56 11 FALSE 0.44
colorectal cancer RAS_13 TET1 Any mutation 99 93 TMB overall 0.24 -2.14 2.58 1430.90 1.00 576 84 78 15 FALSE 0.08
colorectal cancer RAS_13 SMAD3 Any mutation 25 12 TMB quintile 3 -0.34 -1.83 1.13 1574.15 1.00 451 24 11 1 TRUE 0.18
colorectal cancer RAS_13 SMAD3 Any mutation 62 27 TMB quintile 4 -1.13 -3.02 0.20 1570.32 1.00 707 62 27 0 TRUE 0.75
colorectal cancer RAS_13 SMAD3 Any mutation 80 44 TMB quintile 5 -0.31 -1.32 0.53 1409.15 1.00 514 75 39 5 TRUE 0.29
colorectal cancer RAS_13 SMAD3 Any mutation 16 23 TMB quintile 6 -0.44 -1.89 0.67 1419.44 1.00 107 14 21 2 TRUE 0.30
colorectal cancer RAS_13 SMAD3 Any mutation 183 106 TMB overall -0.56 -1.88 0.59 1559.38 1.00 1779 175 98 8 TRUE 0.44
colorectal cancer RAS_13 GRIN2A Any mutation 62 30 TMB quintile 4 -1.69 -4.84 0.12 1401.18 1.00 699 62 30 0 FALSE 0.69
colorectal cancer RAS_13 GRIN2A Any mutation 80 42 TMB quintile 5 -0.24 -1.32 0.65 1301.05 1.00 510 75 37 5 FALSE 0.20
colorectal cancer RAS_13 GRIN2A Any mutation 17 59 TMB quintile 6 0.04 -0.94 1.00 1569.52 1.00 86 10 52 7 FALSE 0.03
colorectal cancer RAS_13 GRIN2A Any mutation 159 131 TMB overall -0.64 -2.62 1.09 1345.16 1.00 1295 147 119 12 FALSE 0.31
colorectal cancer RAS_13 ASXL1 Any mutation 62 15 TMB quintile 4 -1.53 -4.62 0.49 1460.85 1.00 714 62 15 0 TRUE 0.59
colorectal cancer RAS_13 ASXL1 Any mutation 80 30 TMB quintile 5 0.60 -0.33 1.43 1367.29 1.00 524 73 23 7 TRUE 0.72
colorectal cancer RAS_13 ASXL1 Any mutation 17 57 TMB quintile 6 -0.42 -1.61 0.62 1331.75 1.00 82 12 52 5 TRUE 0.35
colorectal cancer RAS_13 ASXL1 Any mutation 159 102 TMB overall -0.45 -2.62 1.42 1583.46 1.00 1320 147 90 12 TRUE 0.18
colorectal cancer RAS_13 EP300 Any mutation 80 39 TMB quintile 5 -1.65 -3.80 -0.20 1351.02 1.00 510 79 38 1 TRUE 1.15
colorectal cancer RAS_13 EP300 Any mutation 19 72 TMB quintile 6 0.03 -0.90 0.95 1567.77 1.00 82 10 63 9 TRUE 0.02
colorectal cancer RAS_13 EP300 Any mutation 99 111 TMB overall -0.76 -3.65 1.89 1522.81 1.00 592 89 101 10 TRUE 0.24
colorectal cancer RAS_13 ERBB4 Any mutation 62 22 TMB quintile 4 0.45 -0.84 1.53 1520.08 1.00 711 59 19 3 TRUE 0.34
colorectal cancer RAS_13 ERBB4 Any mutation 80 45 TMB quintile 5 -0.34 -1.45 0.53 1419.14 1.00 507 76 41 4 TRUE 0.30
colorectal cancer RAS_13 ERBB4 Any mutation 22 61 TMB quintile 6 1.11 0.22 2.03 1451.06 1.00 89 8 47 14 TRUE 1.85
colorectal cancer RAS_13 ERBB4 Any mutation 164 128 TMB overall 0.43 -1.20 2.11 1481.52 1.00 1307 143 107 21 TRUE 0.22
colorectal cancer RAS_13 MED12 Any mutation 62 18 TMB quintile 4 -1.63 -5.03 0.45 1446.43 1.00 712 62 18 0 TRUE 0.60
colorectal cancer RAS_13 MED12 Any mutation 80 28 TMB quintile 5 -0.32 -1.71 0.74 1507.91 1.00 523 77 25 3 TRUE 0.22
colorectal cancer RAS_13 MED12 Any mutation 19 59 TMB quintile 6 0.56 -0.37 1.51 1519.92 1.00 86 9 49 10 TRUE 0.64
colorectal cancer RAS_13 MED12 Any mutation 161 105 TMB overall -0.45 -2.63 1.52 1504.88 1.00 1321 148 92 13 TRUE 0.18
colorectal cancer RAS_13 NF1 Any mutation 62 13 TMB quintile 4 -0.47 -2.64 1.24 1603.49 1.00 718 61 12 1 TRUE 0.19
colorectal cancer RAS_13 NF1 Any mutation 80 34 TMB quintile 5 -0.92 -2.55 0.26 1429.46 1.00 515 78 32 2 TRUE 0.71
colorectal cancer RAS_13 NF1 Any mutation 19 86 TMB quintile 6 -0.10 -1.04 0.86 1426.91 1.00 79 10 77 9 TRUE 0.08
colorectal cancer RAS_13 NF1 Any mutation 161 133 TMB overall -0.51 -2.59 1.49 1430.20 1.00 1312 149 121 12 TRUE 0.21
colorectal cancer RAS_13 EPHA5 Any mutation 62 18 TMB quintile 4 -0.82 -2.96 0.82 1457.06 1.00 712 61 17 1 FALSE 0.40
colorectal cancer RAS_13 EPHA5 Any mutation 80 52 TMB quintile 5 -1.35 -2.85 -0.17 1534.87 1.00 499 78 50 2 FALSE 1.30
colorectal cancer RAS_13 EPHA5 Any mutation 19 66 TMB quintile 6 -0.48 -1.50 0.49 1421.25 1.00 85 13 60 6 FALSE 0.46
colorectal cancer RAS_13 EPHA5 Any mutation 161 136 TMB overall -0.89 -2.84 0.73 1410.87 1.00 1296 152 127 9 FALSE 0.50
colorectal cancer RAS_13 AR Any mutation 62 21 TMB quintile 4 -0.44 -2.27 0.90 1355.82 1.00 709 61 20 1 TRUE 0.23
colorectal cancer RAS_13 AR Any mutation 81 34 TMB quintile 5 0.30 -0.64 1.11 1453.81 1.00 519 75 28 6 TRUE 0.29
colorectal cancer RAS_13 AR Any mutation 20 55 TMB quintile 6 0.44 -0.45 1.30 1498.54 1.00 86 11 46 9 TRUE 0.47
colorectal cancer RAS_13 AR Any mutation 163 110 TMB overall 0.07 -1.52 1.49 1418.61 1.00 1314 147 94 16 TRUE 0.04
colorectal cancer RAS_13 ROS1 Any mutation 62 14 TMB quintile 4 -1.52 -5.19 0.66 1285.29 1.00 715 62 14 0 TRUE 0.52
colorectal cancer RAS_13 ROS1 Any mutation 80 24 TMB quintile 5 -0.62 -2.23 0.69 1534.32 1.00 524 78 22 2 TRUE 0.40
colorectal cancer RAS_13 ROS1 Any mutation 22 61 TMB quintile 6 0.72 -0.14 1.57 1572.23 1.00 93 10 49 12 TRUE 0.95
colorectal cancer RAS_13 ROS1 Any mutation 164 99 TMB overall -0.46 -2.81 1.65 1435.76 1.00 1332 150 85 14 TRUE 0.17
colorectal cancer RAS_13 PIK3CG Any mutation 62 16 TMB quintile 4 -0.74 -2.89 0.91 1455.85 1.00 714 61 15 1 FALSE 0.36
colorectal cancer RAS_13 PIK3CG Any mutation 80 38 TMB quintile 5 -1.51 -3.38 -0.17 1534.41 1.00 509 79 37 1 FALSE 1.22
colorectal cancer RAS_13 PIK3CG Any mutation 18 45 TMB quintile 6 -0.22 -1.30 0.81 1439.39 1.00 98 13 40 5 FALSE 0.16
colorectal cancer RAS_13 PIK3CG Any mutation 160 99 TMB overall -0.82 -2.64 1.02 1529.65 1.00 1321 153 92 7 FALSE 0.43
colorectal cancer RAS_13 ARID1B Any mutation 62 13 TMB quintile 4 -1.87 -5.58 0.51 1429.81 1.00 717 62 13 0 TRUE 0.60
colorectal cancer RAS_13 ARID1B Any mutation 80 46 TMB quintile 5 -0.91 -2.21 0.16 1236.62 1.00 506 77 43 3 TRUE 0.86
colorectal cancer RAS_13 ARID1B Any mutation 16 79 TMB quintile 6 -0.06 -1.08 0.93 1658.98 1.00 73 8 71 8 TRUE 0.05
colorectal cancer RAS_13 ARID1B Any mutation 158 138 TMB overall -0.87 -3.35 1.28 1518.11 1.00 1296 147 127 11 TRUE 0.35
colorectal cancer RAS_13 BRAF Any mutation 25 27 TMB quintile 3 -0.33 -1.84 1.12 1455.70 1.00 437 23 25 2 TRUE 0.18
colorectal cancer RAS_13 BRAF Any mutation 62 60 TMB quintile 4 -0.76 -2.00 0.25 1458.58 1.00 672 59 57 3 TRUE 0.73
colorectal cancer RAS_13 BRAF Any mutation 80 104 TMB quintile 5 -2.20 -3.73 -0.99 1584.11 1.00 446 79 103 1 TRUE 2.83
colorectal cancer RAS_13 BRAF Any mutation 17 59 TMB quintile 6 -0.57 -1.66 0.43 1428.31 1.00 80 12 54 5 TRUE 0.56
colorectal cancer RAS_13 BRAF Any mutation 184 250 TMB overall -0.96 -2.27 0.39 1320.68 1.00 1635 173 239 11 TRUE 0.85
colorectal cancer RAS_13 B2M Any mutation 78 50 TMB quintile 5 -0.87 -2.07 0.19 1362.61 1.00 483 75 47 3 FALSE 0.88
colorectal cancer RAS_13 B2M Any mutation 21 79 TMB quintile 6 0.83 -0.08 1.77 1451.06 1.00 82 7 65 14 FALSE 1.14
colorectal cancer RAS_13 B2M Any mutation 99 129 TMB overall -0.01 -2.24 2.34 1468.35 1.00 565 82 112 17 FALSE 0.00
colorectal cancer RAS_13 CARD11 Any mutation 62 28 TMB quintile 4 -0.24 -1.58 0.91 1054.08 1.00 703 60 26 2 FALSE 0.15
colorectal cancer RAS_13 CARD11 Any mutation 80 43 TMB quintile 5 -0.63 -1.81 0.33 1576.20 1.00 507 77 40 3 FALSE 0.61
colorectal cancer RAS_13 CARD11 Any mutation 19 52 TMB quintile 6 0.52 -0.41 1.40 1493.72 1.00 91 10 43 9 FALSE 0.57
colorectal cancer RAS_13 CARD11 Any mutation 161 123 TMB overall -0.12 -1.57 1.37 1249.64 1.00 1301 147 109 14 FALSE 0.06
colorectal cancer RAS_13 SOX9 Any mutation 25 17 TMB quintile 3 0.49 -0.71 1.65 1441.99 1.00 447 23 15 2 FALSE 0.39
colorectal cancer RAS_13 SOX9 Any mutation 62 85 TMB quintile 4 0.23 -0.49 0.89 1404.78 1.00 656 54 77 8 FALSE 0.29
colorectal cancer RAS_13 SOX9 Any mutation 81 107 TMB quintile 5 0.25 -0.32 0.79 1403.48 1.00 466 65 91 16 FALSE 0.43
colorectal cancer RAS_13 SOX9 Any mutation 18 50 TMB quintile 6 0.55 -0.38 1.42 1609.12 1.00 90 10 42 8 FALSE 0.66
colorectal cancer RAS_13 SOX9 Any mutation 186 259 TMB overall 0.39 -0.54 1.32 1487.61 1.00 1659 152 225 34 FALSE 0.39
colorectal cancer RAS_13 SMAD2 Any mutation 62 29 TMB quintile 4 -0.24 -1.48 0.72 1256.62 1.00 702 61 28 1 TRUE 0.17
colorectal cancer RAS_13 SMAD2 Any mutation 81 53 TMB quintile 5 0.06 -0.76 0.80 1302.51 1.00 506 74 46 7 TRUE 0.06
colorectal cancer RAS_13 SMAD2 Any mutation 17 16 TMB quintile 6 0.53 -0.54 1.64 1496.33 1.00 116 13 12 4 TRUE 0.47
colorectal cancer RAS_13 SMAD2 Any mutation 160 98 TMB overall 0.12 -0.94 1.16 1368.90 1.00 1324 148 86 12 TRUE 0.09
colorectal cancer RAS_13 ZFHX3 Any mutation 56 14 TMB quintile 4 -0.49 -2.90 1.26 1380.96 1.00 651 55 13 1 FALSE 0.20
colorectal cancer RAS_13 ZFHX3 Any mutation 71 63 TMB quintile 5 0.00 -0.83 0.73 1503.29 1.00 459 63 55 8 FALSE 0.00
colorectal cancer RAS_13 ZFHX3 Any mutation 21 143 TMB quintile 6 -0.79 -1.71 0.18 1539.67 1.00 41 9 131 12 FALSE 0.99
colorectal cancer RAS_13 ZFHX3 Any mutation 148 220 TMB overall -0.38 -2.66 1.80 1390.29 1.00 1151 127 199 21 FALSE 0.13
colorectal cancer RAS_13 MGA Any mutation 56 15 TMB quintile 4 0.35 -1.08 1.64 1468.97 1.00 652 54 13 2 FALSE 0.21
colorectal cancer RAS_13 MGA Any mutation 70 46 TMB quintile 5 -0.11 -1.09 0.69 1514.79 1.00 468 65 41 5 FALSE 0.09
colorectal cancer RAS_13 MGA Any mutation 19 58 TMB quintile 6 0.58 -0.34 1.48 1542.92 1.00 79 9 48 10 FALSE 0.69
colorectal cancer RAS_13 MGA Any mutation 145 119 TMB overall 0.27 -1.31 1.93 1391.88 1.00 1199 128 102 17 FALSE 0.13
colorectal cancer RAS_13 KMT2B Any mutation 40 54 TMB quintile 5 0.29 -0.62 1.09 1254.59 1.00 248 32 46 8 FALSE 0.30
colorectal cancer RAS_13 KMT2B Any mutation 13 115 TMB quintile 6 2.28 -0.03 6.39 1283.49 1.00 22 0 102 13 FALSE 0.73
colorectal cancer RAS_13 KMT2B Any mutation 53 169 TMB overall 1.05 -2.16 4.90 1637.56 1.00 270 32 148 21 FALSE 0.27
colorectal cancer RAS_13 TCF7L2 Any mutation 25 35 TMB quintile 3 -0.22 -1.49 0.89 1584.13 1.00 383 23 33 2 FALSE 0.14
colorectal cancer RAS_13 TCF7L2 Any mutation 57 79 TMB quintile 4 -0.16 -1.07 0.58 1436.72 1.00 594 51 73 6 FALSE 0.15
colorectal cancer RAS_13 TCF7L2 Any mutation 72 108 TMB quintile 5 -0.07 -0.73 0.53 1432.68 1.00 420 59 95 13 FALSE 0.08
colorectal cancer RAS_13 TCF7L2 Any mutation 16 70 TMB quintile 6 -0.32 -1.31 0.61 1434.51 1.00 64 10 64 6 FALSE 0.30
colorectal cancer RAS_13 TCF7L2 Any mutation 170 292 TMB overall -0.16 -1.13 0.80 1304.76 1.00 1461 143 265 27 FALSE 0.13
colorectal cancer RAS_13 ANKRD11 Any mutation 55 11 TMB quintile 4 0.49 -1.26 1.95 1327.89 1.00 638 53 9 2 FALSE 0.26
colorectal cancer RAS_13 ANKRD11 Any mutation 67 43 TMB quintile 5 -0.68 -1.90 0.33 1409.84 1.00 437 64 40 3 FALSE 0.62
colorectal cancer RAS_13 ANKRD11 Any mutation 17 86 TMB quintile 6 -0.03 -1.00 0.95 1321.94 1.00 67 8 77 9 FALSE 0.02
colorectal cancer RAS_13 ANKRD11 Any mutation 139 140 TMB overall -0.06 -2.03 1.74 1494.01 1.00 1142 125 126 14 FALSE 0.02
colorectal cancer RAS_13 POLD1 Any mutation 70 20 TMB quintile 5 0.07 -1.40 1.25 1620.24 1.00 494 67 17 3 TRUE 0.04
colorectal cancer RAS_13 POLD1 Any mutation 17 83 TMB quintile 6 0.00 -0.98 1.00 1503.31 1.00 65 8 74 9 TRUE 0.00
colorectal cancer RAS_13 POLD1 Any mutation 87 103 TMB overall 0.01 -2.91 2.86 1493.16 1.00 559 75 91 12 TRUE 0.00
colorectal cancer RAS_13 AMER1 Any mutation 25 13 TMB quintile 3 0.82 -0.56 2.05 1200.36 1.00 451 23 11 2 FALSE 0.63
colorectal cancer RAS_13 AMER1 Any mutation 62 38 TMB quintile 4 -0.18 -1.45 0.89 1521.42 1.00 695 60 36 2 FALSE 0.12
colorectal cancer RAS_13 AMER1 Any mutation 80 62 TMB quintile 5 0.45 -0.22 1.08 1469.35 1.00 495 69 51 11 FALSE 0.74
colorectal cancer RAS_13 AMER1 Any mutation 21 55 TMB quintile 6 1.16 0.35 2.05 1470.48 1.00 90 8 42 13 FALSE 2.12
colorectal cancer RAS_13 AMER1 Any mutation 188 168 TMB overall 0.56 -0.63 1.75 1502.25 1.00 1731 160 140 28 FALSE 0.45
colorectal cancer KRAS_13 SPEN Any mutation 59 11 TMB quintile 4 -2.10 -6.14 0.52 1502.54 1.00 721 59 11 0 FALSE 0.65
colorectal cancer KRAS_13 SPEN Any mutation 76 31 TMB quintile 5 -0.97 -2.62 0.36 1374.07 1.00 525 74 29 2 FALSE 0.68
colorectal cancer KRAS_13 SPEN Any mutation 17 107 TMB quintile 6 -0.87 -1.90 0.05 1507.18 1.00 62 10 100 7 FALSE 1.08
colorectal cancer KRAS_13 SPEN Any mutation 152 149 TMB overall -1.27 -3.90 1.08 1509.98 1.00 1308 143 140 9 FALSE 0.50
colorectal cancer KRAS_13 KMT2C Any mutation 58 12 TMB quintile 4 -0.28 -2.45 1.47 1337.53 1.00 704 57 11 1 FALSE 0.11
colorectal cancer KRAS_13 KMT2C Any mutation 73 61 TMB quintile 5 0.16 -0.64 0.89 1385.01 1.00 471 64 52 9 FALSE 0.16
colorectal cancer KRAS_13 KMT2C Any mutation 19 116 TMB quintile 6 -0.57 -1.48 0.32 1533.76 1.00 62 10 107 9 FALSE 0.63
colorectal cancer KRAS_13 KMT2C Any mutation 150 189 TMB overall -0.23 -2.40 2.00 1439.69 1.00 1237 131 170 19 FALSE 0.08
colorectal cancer KRAS_13 TP53 Any mutation 10 104 TMB quintile 2 -0.57 -1.43 0.26 1404.21 1.00 30 4 98 6 TRUE 0.75
colorectal cancer KRAS_13 TP53 Any mutation 23 411 TMB quintile 3 -0.83 -1.51 -0.14 1476.74 1.00 77 8 396 15 TRUE 1.76
colorectal cancer KRAS_13 TP53 Any mutation 61 655 TMB quintile 4 -0.29 -0.80 0.22 1457.13 1.00 160 15 609 46 TRUE 0.58
colorectal cancer KRAS_13 TP53 Any mutation 80 423 TMB quintile 5 -0.36 -0.78 0.09 1495.96 1.00 213 36 379 44 TRUE 0.96
colorectal cancer KRAS_13 TP53 Any mutation 19 78 TMB quintile 6 -0.20 -0.95 0.54 1519.87 1.00 82 10 69 9 TRUE 0.22
colorectal cancer KRAS_13 TP53 Any mutation 193 1671 TMB overall -0.46 -1.03 0.14 1517.37 1.00 562 73 1551 120 TRUE 0.87
colorectal cancer KRAS_13 ATRX Any mutation 59 19 TMB quintile 4 -1.75 -5.43 0.35 1244.61 1.00 713 59 19 0 TRUE 0.63
colorectal cancer KRAS_13 ATRX Any mutation 76 35 TMB quintile 5 -0.97 -2.49 0.26 1423.20 1.00 519 74 33 2 TRUE 0.76
colorectal cancer KRAS_13 ATRX Any mutation 20 59 TMB quintile 6 0.26 -0.75 1.18 1504.91 1.00 90 11 50 9 TRUE 0.22
colorectal cancer KRAS_13 ATRX Any mutation 155 113 TMB overall -0.77 -2.94 1.10 1213.16 1.00 1322 144 102 11 TRUE 0.34
colorectal cancer KRAS_13 ATR Any mutation 77 35 TMB quintile 5 0.65 -0.24 1.43 1541.74 1.00 523 69 27 8 FALSE 0.90
colorectal cancer KRAS_13 ATR Any mutation 17 65 TMB quintile 6 -1.04 -2.38 0.14 1313.27 1.00 92 14 62 3 FALSE 0.99
colorectal cancer KRAS_13 ATR Any mutation 94 100 TMB overall -0.21 -2.60 2.48 1490.66 1.00 615 83 89 11 FALSE 0.06
colorectal cancer KRAS_13 FBXW7 Any mutation 23 22 TMB quintile 3 -0.50 -2.55 1.00 1406.96 1.00 443 23 22 0 TRUE 0.23
colorectal cancer KRAS_13 FBXW7 Any mutation 61 85 TMB quintile 4 0.50 -0.22 1.16 1529.32 1.00 666 51 75 10 TRUE 0.82
colorectal cancer KRAS_13 FBXW7 Any mutation 79 160 TMB quintile 5 0.48 -0.03 0.95 1381.09 1.00 437 53 134 26 TRUE 1.24
colorectal cancer KRAS_13 FBXW7 Any mutation 15 65 TMB quintile 6 1.15 0.24 2.18 1480.57 1.00 80 4 54 11 TRUE 1.63
colorectal cancer KRAS_13 FBXW7 Any mutation 178 332 TMB overall 0.40 -0.79 1.50 1422.23 1.00 1626 131 285 47 TRUE 0.31
colorectal cancer KRAS_13 FLT4 Any mutation 59 20 TMB quintile 4 -0.13 -1.82 1.19 1537.71 1.00 714 57 18 2 TRUE 0.06
colorectal cancer KRAS_13 FLT4 Any mutation 76 40 TMB quintile 5 -1.05 -2.56 0.10 1411.85 1.00 516 74 38 2 TRUE 0.90
colorectal cancer KRAS_13 FLT4 Any mutation 15 72 TMB quintile 6 -0.61 -1.74 0.46 1491.04 1.00 73 10 67 5 TRUE 0.57
colorectal cancer KRAS_13 FLT4 Any mutation 150 132 TMB overall -0.60 -2.37 1.11 1419.52 1.00 1303 141 123 9 TRUE 0.30
colorectal cancer KRAS_13 PTPRD Any mutation 76 29 TMB quintile 5 -0.39 -1.67 0.73 1209.12 1.00 526 73 26 3 FALSE 0.28
colorectal cancer KRAS_13 PTPRD Any mutation 16 61 TMB quintile 6 -0.66 -1.90 0.42 1454.97 1.00 87 12 57 4 FALSE 0.58
colorectal cancer KRAS_13 PTPRD Any mutation 92 90 TMB overall -0.57 -2.99 1.72 1523.12 1.00 613 85 83 7 FALSE 0.20
colorectal cancer KRAS_13 CREBBP Any mutation 59 17 TMB quintile 4 -0.56 -2.76 1.15 1391.84 1.00 716 58 16 1 TRUE 0.25
colorectal cancer KRAS_13 CREBBP Any mutation 76 49 TMB quintile 5 0.31 -0.53 1.07 1391.25 1.00 516 68 41 8 TRUE 0.35
colorectal cancer KRAS_13 CREBBP Any mutation 18 116 TMB quintile 6 -0.58 -1.52 0.36 1563.03 1.00 55 9 107 9 TRUE 0.64
colorectal cancer KRAS_13 CREBBP Any mutation 153 182 TMB overall -0.30 -2.42 1.85 1320.57 1.00 1287 135 164 18 TRUE 0.11
colorectal cancer KRAS_13 AXIN2 Any mutation 59 20 TMB quintile 4 -0.46 -2.31 1.05 1451.77 1.00 713 58 19 1 TRUE 0.23
colorectal cancer KRAS_13 AXIN2 Any mutation 76 27 TMB quintile 5 0.11 -1.03 1.14 1303.28 1.00 528 72 23 4 TRUE 0.07
colorectal cancer KRAS_13 AXIN2 Any mutation 16 63 TMB quintile 6 0.16 -0.86 1.17 1410.88 1.00 86 9 56 7 TRUE 0.12
colorectal cancer KRAS_13 AXIN2 Any mutation 151 110 TMB overall -0.05 -1.79 1.68 1602.43 1.00 1327 139 98 12 TRUE 0.02
colorectal cancer KRAS_13 PTPRS Any mutation 23 17 TMB quintile 3 -1.18 -4.20 0.94 1628.39 1.00 442 23 17 0 FALSE 0.43
colorectal cancer KRAS_13 PTPRS Any mutation 58 34 TMB quintile 4 0.59 -0.51 1.54 1632.74 1.00 686 53 29 5 FALSE 0.59
colorectal cancer KRAS_13 PTPRS Any mutation 74 74 TMB quintile 5 -0.18 -0.96 0.52 1441.84 1.00 460 66 66 8 FALSE 0.19
colorectal cancer KRAS_13 PTPRS Any mutation 17 128 TMB quintile 6 0.27 -0.76 1.40 1321.64 1.00 45 4 115 13 FALSE 0.21
colorectal cancer KRAS_13 PTPRS Any mutation 172 253 TMB overall -0.12 -1.90 1.38 1494.24 1.00 1633 146 227 26 FALSE 0.05
colorectal cancer KRAS_13 SMARCA4 Any mutation 59 16 TMB quintile 4 -2.01 -5.74 0.32 1414.65 1.00 716 59 16 0 FALSE 0.64
colorectal cancer KRAS_13 SMARCA4 Any mutation 76 47 TMB quintile 5 -0.58 -1.77 0.39 1319.05 1.00 511 72 43 4 FALSE 0.54
colorectal cancer KRAS_13 SMARCA4 Any mutation 17 100 TMB quintile 6 -0.26 -1.26 0.70 1392.55 1.00 67 8 91 9 FALSE 0.22
colorectal cancer KRAS_13 SMARCA4 Any mutation 152 163 TMB overall -0.91 -3.27 1.26 1443.98 1.00 1294 139 150 13 FALSE 0.37
colorectal cancer KRAS_13 PTPRT Any mutation 23 18 TMB quintile 3 0.56 -0.89 1.78 1445.44 1.00 448 21 16 2 FALSE 0.37
colorectal cancer KRAS_13 PTPRT Any mutation 59 39 TMB quintile 4 -0.26 -1.57 0.79 1509.66 1.00 695 57 37 2 FALSE 0.18
colorectal cancer KRAS_13 PTPRT Any mutation 76 59 TMB quintile 5 -0.01 -0.81 0.70 1561.38 1.00 501 69 52 7 FALSE 0.01
colorectal cancer KRAS_13 PTPRT Any mutation 19 66 TMB quintile 6 0.91 0.04 1.80 1348.22 1.00 86 7 54 12 FALSE 1.36
colorectal cancer KRAS_13 PTPRT Any mutation 177 182 TMB overall 0.28 -0.95 1.49 1449.06 1.00 1730 154 159 23 FALSE 0.19
colorectal cancer KRAS_13 PIK3CA Any mutation 23 51 TMB quintile 3 0.74 -0.19 1.64 1366.87 1.00 421 18 46 5 TRUE 0.94
colorectal cancer KRAS_13 PIK3CA Any mutation 59 146 TMB quintile 4 0.21 -0.43 0.80 1429.12 1.00 604 47 134 12 TRUE 0.30
colorectal cancer KRAS_13 PIK3CA Any mutation 83 209 TMB quintile 5 0.79 0.33 1.23 1475.65 1.00 396 43 169 40 TRUE 3.21
colorectal cancer KRAS_13 PIK3CA Any mutation 18 95 TMB quintile 6 0.98 0.13 1.85 1403.06 1.00 68 4 81 14 TRUE 1.54
colorectal cancer KRAS_13 PIK3CA Any mutation 183 501 TMB overall 0.67 -0.27 1.57 1467.57 1.00 1489 112 430 71 TRUE 0.85
colorectal cancer KRAS_13 ALK Any mutation 59 20 TMB quintile 4 1.21 0.10 2.16 1239.27 1.00 717 54 15 5 TRUE 1.74
colorectal cancer KRAS_13 ALK Any mutation 76 42 TMB quintile 5 0.72 -0.01 1.46 1427.39 1.00 519 67 33 9 TRUE 1.26
colorectal cancer KRAS_13 ALK Any mutation 18 45 TMB quintile 6 0.37 -0.60 1.31 1464.20 1.00 98 12 39 6 TRUE 0.35
colorectal cancer KRAS_13 ALK Any mutation 153 107 TMB overall 0.74 -0.76 2.17 1349.77 1.00 1334 133 87 20 TRUE 0.53
colorectal cancer KRAS_13 RNF43 Any mutation 23 12 TMB quintile 3 -1.43 -4.87 0.87 1567.24 1.00 452 23 12 0 TRUE 0.47
colorectal cancer KRAS_13 RNF43 Any mutation 59 30 TMB quintile 4 -0.41 -2.04 0.85 1565.29 1.00 705 57 28 2 TRUE 0.24
colorectal cancer KRAS_13 RNF43 Any mutation 76 76 TMB quintile 5 -0.58 -1.52 0.20 1318.93 1.00 494 70 70 6 TRUE 0.73
colorectal cancer KRAS_13 RNF43 Any mutation 21 146 TMB quintile 6 -0.16 -1.06 0.78 1414.06 1.00 43 6 131 15 TRUE 0.13
colorectal cancer KRAS_13 RNF43 Any mutation 179 264 TMB overall -0.61 -2.46 1.19 1372.66 1.00 1694 156 241 23 TRUE 0.31
colorectal cancer KRAS_13 PTEN Any mutation 59 29 TMB quintile 4 0.54 -0.51 1.55 1529.21 1.00 708 55 25 4 TRUE 0.52
colorectal cancer KRAS_13 PTEN Any mutation 78 69 TMB quintile 5 0.34 -0.35 0.99 1487.04 1.00 506 67 58 11 TRUE 0.49
colorectal cancer KRAS_13 PTEN Any mutation 19 80 TMB quintile 6 0.29 -0.66 1.20 1422.20 1.00 81 9 70 10 TRUE 0.27
colorectal cancer KRAS_13 PTEN Any mutation 156 178 TMB overall 0.41 -1.01 2.00 1422.93 1.00 1295 131 153 25 TRUE 0.23
colorectal cancer KRAS_13 BCOR Any mutation 59 11 TMB quintile 4 -0.21 -2.33 1.41 1397.30 1.00 722 58 10 1 FALSE 0.08
colorectal cancer KRAS_13 BCOR Any mutation 76 39 TMB quintile 5 -0.93 -2.37 0.24 1587.01 1.00 516 74 37 2 FALSE 0.78
colorectal cancer KRAS_13 BCOR Any mutation 17 57 TMB quintile 6 0.40 -0.54 1.38 1539.02 1.00 90 9 49 8 FALSE 0.38
colorectal cancer KRAS_13 BCOR Any mutation 152 107 TMB overall -0.22 -2.19 1.58 1523.11 1.00 1328 141 96 11 FALSE 0.09
colorectal cancer KRAS_13 CTNNB1 Any mutation 23 38 TMB quintile 3 0.51 -0.51 1.43 1399.57 1.00 431 20 35 3 TRUE 0.50
colorectal cancer KRAS_13 CTNNB1 Any mutation 59 35 TMB quintile 4 0.45 -0.46 1.26 1534.73 1.00 702 55 31 4 TRUE 0.52
colorectal cancer KRAS_13 CTNNB1 Any mutation 76 48 TMB quintile 5 0.32 -0.45 1.01 1375.09 1.00 511 69 41 7 TRUE 0.40
colorectal cancer KRAS_13 CTNNB1 Any mutation 15 35 TMB quintile 6 0.92 0.07 1.86 1496.26 1.00 100 8 28 7 TRUE 1.38
colorectal cancer KRAS_13 CTNNB1 Any mutation 173 156 TMB overall 0.56 -0.33 1.42 1439.02 1.00 1744 152 135 21 TRUE 0.69
colorectal cancer KRAS_13 ARID1A Any mutation 59 32 TMB quintile 4 -2.25 -6.23 -0.03 1593.88 1.00 701 59 32 0 TRUE 0.81
colorectal cancer KRAS_13 ARID1A Any mutation 78 116 TMB quintile 5 -0.35 -1.04 0.31 1506.07 1.00 471 67 105 11 TRUE 0.51
colorectal cancer KRAS_13 ARID1A Any mutation 21 155 TMB quintile 6 0.35 -0.69 1.50 1383.00 1.00 49 4 138 17 TRUE 0.27
colorectal cancer KRAS_13 ARID1A Any mutation 158 303 TMB overall -0.68 -3.14 1.62 1499.60 1.00 1221 130 275 28 TRUE 0.24
colorectal cancer KRAS_13 PIK3R1 Any mutation 59 22 TMB quintile 4 -0.66 -2.68 0.91 1506.83 1.00 712 58 21 1 TRUE 0.34
colorectal cancer KRAS_13 PIK3R1 Any mutation 76 29 TMB quintile 5 -0.69 -2.13 0.48 1534.59 1.00 526 74 27 2 TRUE 0.52
colorectal cancer KRAS_13 PIK3R1 Any mutation 16 56 TMB quintile 6 0.25 -0.76 1.22 1537.34 1.00 91 9 49 7 TRUE 0.20
colorectal cancer KRAS_13 PIK3R1 Any mutation 151 107 TMB overall -0.38 -2.19 1.42 1587.78 1.00 1329 141 97 10 TRUE 0.17
colorectal cancer KRAS_13 FAT1 Any mutation 59 17 TMB quintile 4 -1.98 -6.04 0.49 1497.92 1.00 716 59 17 0 FALSE 0.62
colorectal cancer KRAS_13 FAT1 Any mutation 76 64 TMB quintile 5 -0.37 -1.30 0.43 1393.56 1.00 501 70 58 6 FALSE 0.38
colorectal cancer KRAS_13 FAT1 Any mutation 28 145 TMB quintile 6 1.01 0.08 2.08 1436.68 1.00 59 4 121 24 FALSE 1.33
colorectal cancer KRAS_13 FAT1 Any mutation 163 226 TMB overall -0.43 -3.06 1.85 1579.85 1.00 1276 133 196 30 FALSE 0.14
colorectal cancer KRAS_13 CIC Any mutation 59 17 TMB quintile 4 0.06 -1.59 1.47 1440.36 1.00 718 57 15 2 TRUE 0.03
colorectal cancer KRAS_13 CIC Any mutation 77 40 TMB quintile 5 -0.64 -1.89 0.40 1426.87 1.00 517 74 37 3 TRUE 0.57
colorectal cancer KRAS_13 CIC Any mutation 16 79 TMB quintile 6 -0.76 -1.92 0.21 1578.46 1.00 75 11 74 5 TRUE 0.79
colorectal cancer KRAS_13 CIC Any mutation 152 136 TMB overall -0.40 -2.22 1.55 1467.89 1.00 1310 142 126 10 TRUE 0.17
colorectal cancer KRAS_13 NCOR1 Any mutation 59 16 TMB quintile 4 0.27 -1.34 1.57 1538.87 1.00 718 57 14 2 FALSE 0.14
colorectal cancer KRAS_13 NCOR1 Any mutation 76 32 TMB quintile 5 -0.34 -1.55 0.76 1164.87 1.00 527 73 29 3 FALSE 0.25
colorectal cancer KRAS_13 NCOR1 Any mutation 17 81 TMB quintile 6 0.16 -0.81 1.18 1357.95 1.00 73 8 72 9 FALSE 0.13
colorectal cancer KRAS_13 NCOR1 Any mutation 152 129 TMB overall 0.04 -1.88 1.89 1403.20 1.00 1318 138 115 14 FALSE 0.01
colorectal cancer KRAS_13 POLE Any mutation 76 38 TMB quintile 5 -0.20 -1.36 0.76 1498.66 1.00 518 72 34 4 TRUE 0.15
colorectal cancer KRAS_13 POLE Any mutation 19 93 TMB quintile 6 0.58 -0.30 1.62 1651.02 1.00 69 6 80 13 TRUE 0.63
colorectal cancer KRAS_13 POLE Any mutation 95 131 TMB overall 0.15 -2.57 2.63 1450.55 1.00 587 78 114 17 TRUE 0.04
colorectal cancer KRAS_13 TGFBR2 Any mutation 76 47 TMB quintile 5 0.18 -0.67 0.93 1373.80 1.00 515 69 40 7 TRUE 0.18
colorectal cancer KRAS_13 TGFBR2 Any mutation 15 57 TMB quintile 6 0.01 -1.05 1.01 1637.97 1.00 77 9 51 6 TRUE 0.01
colorectal cancer KRAS_13 TGFBR2 Any mutation 91 104 TMB overall 0.10 -1.98 2.18 1268.92 1.00 592 78 91 13 TRUE 0.03
colorectal cancer KRAS_13 KMT2A Any mutation 59 16 TMB quintile 4 -1.63 -5.40 0.57 1542.07 1.00 716 59 16 0 FALSE 0.51
colorectal cancer KRAS_13 KMT2A Any mutation 77 43 TMB quintile 5 0.26 -0.64 1.04 1474.98 1.00 517 70 36 7 FALSE 0.26
colorectal cancer KRAS_13 KMT2A Any mutation 20 84 TMB quintile 6 0.23 -0.68 1.14 1396.63 1.00 79 9 73 11 FALSE 0.21
colorectal cancer KRAS_13 KMT2A Any mutation 156 143 TMB overall -0.40 -2.91 1.67 1454.22 1.00 1312 138 125 18 FALSE 0.14
colorectal cancer KRAS_13 BRCA2 Any mutation 59 21 TMB quintile 4 0.47 -0.90 1.62 1457.68 1.00 714 56 18 3 TRUE 0.34
colorectal cancer KRAS_13 BRCA2 Any mutation 78 48 TMB quintile 5 0.14 -0.76 0.89 1541.15 1.00 515 71 41 7 TRUE 0.13
colorectal cancer KRAS_13 BRCA2 Any mutation 22 116 TMB quintile 6 -0.30 -1.15 0.52 1552.81 1.00 70 11 105 11 TRUE 0.32
colorectal cancer KRAS_13 BRCA2 Any mutation 159 185 TMB overall 0.15 -1.74 2.08 1337.37 1.00 1299 138 164 21 TRUE 0.06
colorectal cancer KRAS_13 NOTCH3 Any mutation 23 12 TMB quintile 3 0.16 -1.97 1.93 1423.66 1.00 453 22 11 1 TRUE 0.06
colorectal cancer KRAS_13 NOTCH3 Any mutation 59 17 TMB quintile 4 0.21 -1.45 1.50 1410.54 1.00 717 57 15 2 TRUE 0.11
colorectal cancer KRAS_13 NOTCH3 Any mutation 76 50 TMB quintile 5 0.13 -0.75 0.91 1400.26 1.00 512 69 43 7 TRUE 0.12
colorectal cancer KRAS_13 NOTCH3 Any mutation 16 120 TMB quintile 6 -0.10 -1.05 0.90 1563.29 1.00 53 6 110 10 TRUE 0.08
colorectal cancer KRAS_13 NOTCH3 Any mutation 174 199 TMB overall 0.10 -1.64 1.81 1541.92 1.00 1735 154 179 20 TRUE 0.04
colorectal cancer KRAS_13 NOTCH4 Any mutation 58 21 TMB quintile 4 0.33 -1.08 1.50 1684.38 1.00 698 55 18 3 TRUE 0.21
colorectal cancer KRAS_13 NOTCH4 Any mutation 73 37 TMB quintile 5 -2.56 -6.61 -0.51 1563.14 1.00 480 73 37 0 TRUE 0.96
colorectal cancer KRAS_13 NOTCH4 Any mutation 18 59 TMB quintile 6 -0.10 -1.12 0.88 1229.96 1.00 82 11 52 7 TRUE 0.07
colorectal cancer KRAS_13 NOTCH4 Any mutation 149 117 TMB overall -0.72 -3.06 1.26 1524.68 1.00 1260 139 107 10 TRUE 0.29
colorectal cancer KRAS_13 ERBB3 Any mutation 59 27 TMB quintile 4 -1.37 -4.11 0.38 1538.53 1.00 706 59 27 0 TRUE 0.60
colorectal cancer KRAS_13 ERBB3 Any mutation 76 39 TMB quintile 5 0.16 -0.75 1.03 1501.08 1.00 518 70 33 6 TRUE 0.14
colorectal cancer KRAS_13 ERBB3 Any mutation 17 51 TMB quintile 6 0.76 -0.20 1.73 1363.71 1.00 94 8 42 9 TRUE 0.92
colorectal cancer KRAS_13 ERBB3 Any mutation 152 117 TMB overall -0.16 -2.16 1.52 1531.94 1.00 1318 137 102 15 TRUE 0.06
colorectal cancer KRAS_13 SMAD4 Any mutation 23 51 TMB quintile 3 -0.42 -1.32 0.51 1438.93 1.00 418 20 48 3 TRUE 0.43
colorectal cancer KRAS_13 SMAD4 Any mutation 59 129 TMB quintile 4 -0.80 -1.63 -0.11 1585.49 1.00 613 55 125 4 TRUE 1.42
colorectal cancer KRAS_13 SMAD4 Any mutation 78 138 TMB quintile 5 -0.41 -1.02 0.16 1447.29 1.00 440 65 125 13 TRUE 0.76
colorectal cancer KRAS_13 SMAD4 Any mutation 15 31 TMB quintile 6 -0.76 -1.82 0.12 1396.33 1.00 103 14 30 1 TRUE 0.91
colorectal cancer KRAS_13 SMAD4 Any mutation 175 349 TMB overall -0.60 -1.36 0.12 1308.49 1.00 1574 154 328 21 TRUE 0.96
colorectal cancer KRAS_13 ATM Any mutation 60 46 TMB quintile 4 0.05 -1.06 0.93 1555.76 1.00 694 56 42 4 TRUE 0.04
colorectal cancer KRAS_13 ATM Any mutation 77 78 TMB quintile 5 -0.07 -0.82 0.58 1459.57 1.00 489 68 69 9 TRUE 0.07
colorectal cancer KRAS_13 ATM Any mutation 20 94 TMB quintile 6 0.37 -0.52 1.26 1380.57 1.00 79 8 82 12 TRUE 0.40
colorectal cancer KRAS_13 ATM Any mutation 157 218 TMB overall 0.10 -1.36 1.48 1345.06 1.00 1262 132 193 25 TRUE 0.05
colorectal cancer KRAS_13 KMT2D Any mutation 59 27 TMB quintile 4 -1.04 -3.49 0.58 1523.38 1.00 707 58 26 1 FALSE 0.52
colorectal cancer KRAS_13 KMT2D Any mutation 76 104 TMB quintile 5 -0.43 -1.20 0.26 1524.06 1.00 484 67 95 9 FALSE 0.62
colorectal cancer KRAS_13 KMT2D Any mutation 26 245 TMB quintile 6 -0.43 -1.65 1.00 1485.64 1.00 16 3 222 23 FALSE 0.29
colorectal cancer KRAS_13 KMT2D Any mutation 161 376 TMB overall -0.61 -3.20 1.97 1503.29 1.00 1207 128 343 33 FALSE 0.20
colorectal cancer KRAS_13 TSC2 Any mutation 76 42 TMB quintile 5 -0.42 -1.57 0.61 1559.31 1.00 519 72 38 4 TRUE 0.37
colorectal cancer KRAS_13 TSC2 Any mutation 16 56 TMB quintile 6 -0.60 -1.81 0.47 1412.71 1.00 86 12 52 4 TRUE 0.54
colorectal cancer KRAS_13 TSC2 Any mutation 92 98 TMB overall -0.43 -2.40 1.78 1226.15 1.00 605 84 90 8 TRUE 0.16
colorectal cancer KRAS_13 APC Any mutation 10 78 TMB quintile 2 -0.06 -0.98 0.90 1431.95 1.00 63 5 73 5 TRUE 0.05
colorectal cancer KRAS_13 APC Any mutation 24 428 TMB quintile 3 -0.68 -1.42 0.01 1472.70 1.00 146 12 416 12 TRUE 1.17
colorectal cancer KRAS_13 APC Any mutation 84 966 TMB quintile 4 0.24 -0.30 0.84 1348.73 1.00 143 9 891 75 TRUE 0.39
colorectal cancer KRAS_13 APC Any mutation 132 822 TMB quintile 5 0.82 0.28 1.43 1517.83 1.00 142 9 699 123 TRUE 2.29
colorectal cancer KRAS_13 APC Any mutation 31 225 TMB quintile 6 0.21 -0.54 0.97 1324.22 1.00 42 5 199 26 TRUE 0.23
colorectal cancer KRAS_13 APC Any mutation 281 2519 TMB overall 0.10 -0.58 0.78 1428.12 1.00 536 40 2278 241 TRUE 0.11
colorectal cancer KRAS_13 ERBB2 Any mutation 59 17 TMB quintile 4 0.37 -1.11 1.64 1466.95 1.00 717 57 15 2 TRUE 0.24
colorectal cancer KRAS_13 ERBB2 Any mutation 76 33 TMB quintile 5 0.63 -0.22 1.40 1507.80 1.00 524 69 26 7 TRUE 0.86
colorectal cancer KRAS_13 ERBB2 Any mutation 16 42 TMB quintile 6 0.52 -0.53 1.52 1348.22 1.00 98 10 36 6 TRUE 0.51
colorectal cancer KRAS_13 ERBB2 Any mutation 151 92 TMB overall 0.51 -0.95 1.93 1468.18 1.00 1339 136 77 15 TRUE 0.31
colorectal cancer KRAS_13 ARID2 Any mutation 59 12 TMB quintile 4 0.43 -1.32 1.89 1510.48 1.00 722 57 10 2 FALSE 0.22
colorectal cancer KRAS_13 ARID2 Any mutation 76 31 TMB quintile 5 -0.74 -2.27 0.42 1382.15 1.00 523 74 29 2 FALSE 0.56
colorectal cancer KRAS_13 ARID2 Any mutation 16 66 TMB quintile 6 -0.25 -1.36 0.76 1528.79 1.00 78 10 60 6 FALSE 0.19
colorectal cancer KRAS_13 ARID2 Any mutation 151 109 TMB overall -0.22 -2.21 1.70 1464.60 1.00 1323 141 99 10 FALSE 0.08
colorectal cancer KRAS_13 MTOR Any mutation 59 19 TMB quintile 4 -0.39 -2.21 1.04 1617.67 1.00 714 58 18 1 TRUE 0.19
colorectal cancer KRAS_13 MTOR Any mutation 76 40 TMB quintile 5 0.38 -0.50 1.17 1643.87 1.00 518 69 33 7 TRUE 0.42
colorectal cancer KRAS_13 MTOR Any mutation 19 70 TMB quintile 6 0.42 -0.58 1.39 1366.19 1.00 83 9 60 10 TRUE 0.42
colorectal cancer KRAS_13 MTOR Any mutation 154 129 TMB overall 0.11 -1.74 1.81 1258.87 1.00 1315 136 111 18 TRUE 0.05
colorectal cancer KRAS_13 NOTCH1 Any mutation 77 48 TMB quintile 5 -0.52 -1.62 0.44 1332.21 1.00 509 73 44 4 TRUE 0.49
colorectal cancer KRAS_13 NOTCH1 Any mutation 21 112 TMB quintile 6 0.20 -0.68 1.23 1344.80 1.00 60 7 98 14 TRUE 0.17
colorectal cancer KRAS_13 NOTCH1 Any mutation 98 160 TMB overall -0.16 -2.74 2.66 1477.78 1.00 569 80 142 18 TRUE 0.04
colorectal cancer KRAS_13 SETD2 Any mutation 23 11 TMB quintile 3 -0.92 -4.01 1.24 1346.46 1.00 454 23 11 0 FALSE 0.29
colorectal cancer KRAS_13 SETD2 Any mutation 77 31 TMB quintile 5 0.22 -0.88 1.17 1407.37 1.00 526 72 26 5 FALSE 0.18
colorectal cancer KRAS_13 SETD2 Any mutation 19 64 TMB quintile 6 0.54 -0.39 1.44 1539.12 1.00 86 9 54 10 FALSE 0.62
colorectal cancer KRAS_13 SETD2 Any mutation 119 106 TMB overall -0.10 -2.35 1.80 1517.51 1.00 1066 104 91 15 FALSE 0.03
colorectal cancer KRAS_13 EPHA3 Any mutation 59 17 TMB quintile 4 0.17 -1.29 1.44 1460.87 1.00 718 57 15 2 FALSE 0.09
colorectal cancer KRAS_13 EPHA3 Any mutation 76 41 TMB quintile 5 -0.02 -1.03 0.90 1526.61 1.00 515 71 36 5 FALSE 0.02
colorectal cancer KRAS_13 EPHA3 Any mutation 17 44 TMB quintile 6 0.03 -1.02 1.07 1233.38 1.00 95 12 39 5 FALSE 0.02
colorectal cancer KRAS_13 EPHA3 Any mutation 152 102 TMB overall 0.06 -1.55 1.56 1285.88 1.00 1328 140 90 12 FALSE 0.03
colorectal cancer KRAS_13 PTCH1 Any mutation 77 35 TMB quintile 5 0.30 -0.66 1.17 1633.44 1.00 522 71 29 6 TRUE 0.27
colorectal cancer KRAS_13 PTCH1 Any mutation 22 99 TMB quintile 6 -0.09 -0.95 0.87 1458.22 1.00 64 10 87 12 TRUE 0.07
colorectal cancer KRAS_13 PTCH1 Any mutation 99 134 TMB overall 0.14 -2.53 2.86 1448.10 1.00 586 81 116 18 TRUE 0.04
colorectal cancer KRAS_13 TET1 Any mutation 73 26 TMB quintile 5 0.14 -1.02 1.13 1452.50 1.00 496 69 22 4 FALSE 0.10
colorectal cancer KRAS_13 TET1 Any mutation 21 67 TMB quintile 6 0.28 -0.65 1.20 1407.85 1.00 84 11 57 10 FALSE 0.26
colorectal cancer KRAS_13 TET1 Any mutation 94 93 TMB overall 0.19 -2.14 2.78 1551.84 1.00 580 80 79 14 FALSE 0.06
colorectal cancer KRAS_13 SMAD3 Any mutation 23 12 TMB quintile 3 -0.20 -1.81 1.28 1612.21 1.00 453 22 11 1 TRUE 0.10
colorectal cancer KRAS_13 SMAD3 Any mutation 59 27 TMB quintile 4 -1.01 -2.93 0.33 1376.90 1.00 710 59 27 0 TRUE 0.65
colorectal cancer KRAS_13 SMAD3 Any mutation 76 44 TMB quintile 5 -0.22 -1.19 0.65 1395.78 1.00 518 71 39 5 TRUE 0.19
colorectal cancer KRAS_13 SMAD3 Any mutation 15 23 TMB quintile 6 -0.35 -1.76 0.94 1337.22 1.00 108 13 21 2 TRUE 0.22
colorectal cancer KRAS_13 SMAD3 Any mutation 173 106 TMB overall -0.45 -1.69 0.66 1427.07 1.00 1789 165 98 8 TRUE 0.35
colorectal cancer KRAS_13 GRIN2A Any mutation 59 30 TMB quintile 4 -1.74 -4.96 0.14 1435.22 1.00 702 59 30 0 FALSE 0.75
colorectal cancer KRAS_13 GRIN2A Any mutation 76 42 TMB quintile 5 -0.42 -1.47 0.51 1746.53 1.00 513 72 38 4 FALSE 0.38
colorectal cancer KRAS_13 GRIN2A Any mutation 16 59 TMB quintile 6 0.12 -0.88 1.06 1452.07 1.00 87 9 52 7 FALSE 0.09
colorectal cancer KRAS_13 GRIN2A Any mutation 151 131 TMB overall -0.64 -2.65 1.14 1312.84 1.00 1302 140 120 11 FALSE 0.31
colorectal cancer KRAS_13 ASXL1 Any mutation 59 15 TMB quintile 4 -1.78 -5.88 0.47 1591.96 1.00 717 59 15 0 TRUE 0.57
colorectal cancer KRAS_13 ASXL1 Any mutation 76 30 TMB quintile 5 0.64 -0.35 1.59 1772.18 1.00 528 69 23 7 TRUE 0.73
colorectal cancer KRAS_13 ASXL1 Any mutation 15 57 TMB quintile 6 -0.96 -2.24 0.15 1418.46 1.00 82 12 54 3 TRUE 0.93
colorectal cancer KRAS_13 ASXL1 Any mutation 150 102 TMB overall -0.66 -3.03 1.33 1399.99 1.00 1327 140 92 10 TRUE 0.25
colorectal cancer KRAS_13 EP300 Any mutation 76 39 TMB quintile 5 -1.65 -3.59 -0.16 1311.90 1.00 514 75 38 1 TRUE 1.25
colorectal cancer KRAS_13 EP300 Any mutation 18 72 TMB quintile 6 0.16 -0.87 1.16 1399.95 1.00 83 9 63 9 TRUE 0.12
colorectal cancer KRAS_13 EP300 Any mutation 94 111 TMB overall -0.69 -3.16 1.86 1344.52 1.00 597 84 101 10 TRUE 0.23
colorectal cancer KRAS_13 ERBB4 Any mutation 59 22 TMB quintile 4 0.51 -0.76 1.63 1398.68 1.00 714 56 19 3 TRUE 0.40
colorectal cancer KRAS_13 ERBB4 Any mutation 76 45 TMB quintile 5 -0.28 -1.30 0.60 1602.05 1.00 511 72 41 4 TRUE 0.24
colorectal cancer KRAS_13 ERBB4 Any mutation 21 61 TMB quintile 6 1.03 0.15 1.89 1455.99 1.00 89 8 48 13 TRUE 1.63
colorectal cancer KRAS_13 ERBB4 Any mutation 156 128 TMB overall 0.41 -1.16 1.94 1627.55 1.00 1314 136 108 20 TRUE 0.22
colorectal cancer KRAS_13 MED12 Any mutation 59 18 TMB quintile 4 -1.55 -4.74 0.55 1530.13 1.00 715 59 18 0 TRUE 0.59
colorectal cancer KRAS_13 MED12 Any mutation 76 28 TMB quintile 5 -0.27 -1.54 0.81 1594.41 1.00 527 73 25 3 TRUE 0.19
colorectal cancer KRAS_13 MED12 Any mutation 18 59 TMB quintile 6 0.66 -0.25 1.64 1309.32 1.00 87 8 49 10 TRUE 0.76
colorectal cancer KRAS_13 MED12 Any mutation 153 105 TMB overall -0.39 -2.55 1.61 1305.04 1.00 1329 140 92 13 TRUE 0.14
colorectal cancer KRAS_13 NF1 Any mutation 59 13 TMB quintile 4 -0.40 -2.58 1.23 1450.06 1.00 721 58 12 1 TRUE 0.17
colorectal cancer KRAS_13 NF1 Any mutation 76 34 TMB quintile 5 -0.90 -2.48 0.33 1535.77 1.00 519 74 32 2 TRUE 0.69
colorectal cancer KRAS_13 NF1 Any mutation 18 86 TMB quintile 6 -0.25 -1.23 0.71 1365.92 1.00 79 10 78 8 TRUE 0.22
colorectal cancer KRAS_13 NF1 Any mutation 153 133 TMB overall -0.56 -2.72 1.42 1431.66 1.00 1319 142 122 11 TRUE 0.23
colorectal cancer KRAS_13 EPHA5 Any mutation 59 18 TMB quintile 4 -0.82 -2.90 0.75 1429.59 1.00 715 58 17 1 FALSE 0.42
colorectal cancer KRAS_13 EPHA5 Any mutation 76 52 TMB quintile 5 -1.34 -2.73 -0.15 1250.80 1.00 503 74 50 2 FALSE 1.35
colorectal cancer KRAS_13 EPHA5 Any mutation 18 66 TMB quintile 6 -0.69 -1.78 0.34 1569.65 1.00 85 13 61 5 FALSE 0.70
colorectal cancer KRAS_13 EPHA5 Any mutation 153 136 TMB overall -0.93 -2.80 0.85 1355.26 1.00 1303 145 128 8 FALSE 0.52
colorectal cancer KRAS_13 AR Any mutation 59 21 TMB quintile 4 -1.51 -4.88 0.36 1414.67 1.00 711 59 21 0 TRUE 0.58
colorectal cancer KRAS_13 AR Any mutation 77 34 TMB quintile 5 0.28 -0.67 1.16 1751.56 1.00 523 71 28 6 TRUE 0.26
colorectal cancer KRAS_13 AR Any mutation 17 55 TMB quintile 6 -0.11 -1.21 0.92 1550.56 1.00 86 11 49 6 TRUE 0.08
colorectal cancer KRAS_13 AR Any mutation 153 110 TMB overall -0.43 -2.27 1.31 1457.80 1.00 1320 141 98 12 TRUE 0.20
colorectal cancer KRAS_13 ROS1 Any mutation 59 14 TMB quintile 4 -1.49 -5.14 0.77 1441.50 1.00 718 59 14 0 TRUE 0.50
colorectal cancer KRAS_13 ROS1 Any mutation 76 24 TMB quintile 5 -0.57 -2.08 0.70 1494.93 1.00 528 74 22 2 TRUE 0.36
colorectal cancer KRAS_13 ROS1 Any mutation 21 61 TMB quintile 6 0.82 -0.09 1.81 1374.86 1.00 94 9 49 12 TRUE 1.07
colorectal cancer KRAS_13 ROS1 Any mutation 156 99 TMB overall -0.44 -2.87 1.57 1584.21 1.00 1340 142 85 14 TRUE 0.15
colorectal cancer KRAS_13 PIK3CG Any mutation 59 16 TMB quintile 4 -0.66 -2.76 0.90 1385.44 1.00 717 58 15 1 FALSE 0.32
colorectal cancer KRAS_13 PIK3CG Any mutation 76 38 TMB quintile 5 -1.48 -3.25 -0.14 1454.21 1.00 513 75 37 1 FALSE 1.16
colorectal cancer KRAS_13 PIK3CG Any mutation 17 45 TMB quintile 6 -0.14 -1.30 0.89 1436.34 1.00 99 12 40 5 FALSE 0.10
colorectal cancer KRAS_13 PIK3CG Any mutation 152 99 TMB overall -0.72 -2.69 1.02 1456.26 1.00 1329 145 92 7 FALSE 0.37
colorectal cancer KRAS_13 ARID1B Any mutation 59 13 TMB quintile 4 -1.85 -5.87 0.64 1523.29 1.00 720 59 13 0 TRUE 0.60
colorectal cancer KRAS_13 ARID1B Any mutation 76 46 TMB quintile 5 -0.82 -2.10 0.29 1736.22 1.00 510 73 43 3 TRUE 0.74
colorectal cancer KRAS_13 ARID1B Any mutation 15 79 TMB quintile 6 0.09 -0.95 1.14 1512.58 1.00 74 7 71 8 TRUE 0.06
colorectal cancer KRAS_13 ARID1B Any mutation 150 138 TMB overall -0.82 -3.22 1.26 1474.48 1.00 1304 139 127 11 TRUE 0.34
colorectal cancer KRAS_13 BRAF Any mutation 23 27 TMB quintile 3 -0.36 -2.07 1.10 1451.62 1.00 439 21 25 2 TRUE 0.18
colorectal cancer KRAS_13 BRAF Any mutation 59 60 TMB quintile 4 -0.82 -2.11 0.28 1331.05 1.00 675 56 57 3 TRUE 0.75
colorectal cancer KRAS_13 BRAF Any mutation 76 104 TMB quintile 5 -2.86 -5.32 -1.39 1312.40 1.00 449 76 104 0 TRUE 2.34
colorectal cancer KRAS_13 BRAF Any mutation 15 59 TMB quintile 6 -1.10 -2.42 0.04 1589.26 1.00 80 12 56 3 TRUE 1.11
colorectal cancer KRAS_13 BRAF Any mutation 173 250 TMB overall -1.24 -2.66 0.13 1528.02 1.00 1643 165 242 8 TRUE 1.07
colorectal cancer KRAS_13 B2M Any mutation 74 50 TMB quintile 5 -0.78 -2.05 0.23 1452.18 1.00 487 71 47 3 FALSE 0.74
colorectal cancer KRAS_13 B2M Any mutation 20 79 TMB quintile 6 0.71 -0.18 1.68 1374.96 1.00 82 7 66 13 FALSE 0.86
colorectal cancer KRAS_13 B2M Any mutation 94 129 TMB overall -0.06 -2.43 2.26 1464.59 1.00 569 78 113 16 FALSE 0.02
colorectal cancer KRAS_13 CARD11 Any mutation 59 28 TMB quintile 4 -0.21 -1.64 1.00 1501.20 1.00 706 57 26 2 FALSE 0.12
colorectal cancer KRAS_13 CARD11 Any mutation 76 43 TMB quintile 5 -0.61 -1.77 0.38 1506.51 1.00 511 73 40 3 FALSE 0.56
colorectal cancer KRAS_13 CARD11 Any mutation 18 52 TMB quintile 6 0.39 -0.56 1.35 1196.92 1.00 91 10 44 8 FALSE 0.38
colorectal cancer KRAS_13 CARD11 Any mutation 153 123 TMB overall -0.16 -1.55 1.29 1586.34 1.00 1308 140 110 13 FALSE 0.08
colorectal cancer KRAS_13 SOX9 Any mutation 23 17 TMB quintile 3 0.58 -0.64 1.79 1499.87 1.00 449 21 15 2 FALSE 0.45
colorectal cancer KRAS_13 SOX9 Any mutation 59 85 TMB quintile 4 0.30 -0.44 0.99 1634.76 1.00 659 51 77 8 FALSE 0.38
colorectal cancer KRAS_13 SOX9 Any mutation 77 107 TMB quintile 5 0.32 -0.24 0.86 1544.27 1.00 470 61 91 16 FALSE 0.59
colorectal cancer KRAS_13 SOX9 Any mutation 17 50 TMB quintile 6 0.45 -0.47 1.30 1358.22 1.00 90 10 43 7 FALSE 0.49
colorectal cancer KRAS_13 SOX9 Any mutation 176 259 TMB overall 0.41 -0.55 1.32 1364.53 1.00 1668 143 226 33 FALSE 0.42
colorectal cancer KRAS_13 SMAD2 Any mutation 59 29 TMB quintile 4 -0.21 -1.62 0.81 1562.75 1.00 705 58 28 1 TRUE 0.14
colorectal cancer KRAS_13 SMAD2 Any mutation 77 53 TMB quintile 5 0.13 -0.70 0.83 1438.64 1.00 510 70 46 7 TRUE 0.13
colorectal cancer KRAS_13 SMAD2 Any mutation 16 16 TMB quintile 6 0.58 -0.45 1.68 1368.83 1.00 117 12 12 4 TRUE 0.54
colorectal cancer KRAS_13 SMAD2 Any mutation 152 98 TMB overall 0.16 -0.91 1.11 1482.17 1.00 1332 140 86 12 TRUE 0.12
colorectal cancer KRAS_13 ZFHX3 Any mutation 53 14 TMB quintile 4 -0.47 -2.55 1.24 1435.38 1.00 654 52 13 1 FALSE 0.19
colorectal cancer KRAS_13 ZFHX3 Any mutation 67 63 TMB quintile 5 0.06 -0.80 0.86 1526.32 1.00 463 59 55 8 FALSE 0.05
colorectal cancer KRAS_13 ZFHX3 Any mutation 19 143 TMB quintile 6 -0.97 -1.92 0.00 1495.11 1.00 41 9 133 10 FALSE 1.33
colorectal cancer KRAS_13 ZFHX3 Any mutation 139 220 TMB overall -0.43 -2.71 1.84 1583.47 1.00 1158 120 201 19 FALSE 0.15
colorectal cancer KRAS_13 MGA Any mutation 53 15 TMB quintile 4 0.34 -1.14 1.70 1454.47 1.00 655 51 13 2 FALSE 0.20
colorectal cancer KRAS_13 MGA Any mutation 66 46 TMB quintile 5 -0.07 -1.01 0.80 1487.02 1.00 472 61 41 5 FALSE 0.06
colorectal cancer KRAS_13 MGA Any mutation 18 58 TMB quintile 6 0.47 -0.45 1.38 1586.01 1.00 79 9 49 9 FALSE 0.50
colorectal cancer KRAS_13 MGA Any mutation 137 119 TMB overall 0.27 -1.43 1.93 1202.80 1.00 1206 121 103 16 FALSE 0.13
colorectal cancer KRAS_13 KMT2B Any mutation 39 54 TMB quintile 5 0.35 -0.50 1.16 1592.36 1.00 249 31 46 8 FALSE 0.39
colorectal cancer KRAS_13 KMT2B Any mutation 13 115 TMB quintile 6 2.31 -0.03 6.83 1358.63 1.00 22 0 102 13 FALSE 0.70
colorectal cancer KRAS_13 KMT2B Any mutation 52 169 TMB overall 1.27 -1.93 5.51 1449.58 1.00 271 31 148 21 FALSE 0.32
colorectal cancer KRAS_13 TCF7L2 Any mutation 23 35 TMB quintile 3 -0.13 -1.34 0.95 1480.78 1.00 385 21 33 2 FALSE 0.08
colorectal cancer KRAS_13 TCF7L2 Any mutation 54 79 TMB quintile 4 -0.25 -1.11 0.54 1512.73 1.00 596 49 74 5 FALSE 0.25
colorectal cancer KRAS_13 TCF7L2 Any mutation 68 108 TMB quintile 5 0.01 -0.61 0.60 1465.97 1.00 424 55 95 13 FALSE 0.02
colorectal cancer KRAS_13 TCF7L2 Any mutation 15 70 TMB quintile 6 -0.25 -1.21 0.63 1571.50 1.00 65 9 64 6 FALSE 0.23
colorectal cancer KRAS_13 TCF7L2 Any mutation 160 292 TMB overall -0.16 -1.22 0.79 1553.63 1.00 1470 134 266 26 FALSE 0.12
colorectal cancer KRAS_13 ANKRD11 Any mutation 52 11 TMB quintile 4 0.60 -1.13 2.04 1469.65 1.00 641 50 9 2 FALSE 0.33
colorectal cancer KRAS_13 ANKRD11 Any mutation 63 43 TMB quintile 5 -0.61 -1.76 0.43 1482.19 1.00 441 60 40 3 FALSE 0.55
colorectal cancer KRAS_13 ANKRD11 Any mutation 16 86 TMB quintile 6 0.15 -0.86 1.18 1380.89 1.00 68 7 77 9 FALSE 0.12
colorectal cancer KRAS_13 ANKRD11 Any mutation 131 140 TMB overall 0.05 -2.05 2.06 1439.01 1.00 1150 117 126 14 FALSE 0.02
colorectal cancer KRAS_13 POLD1 Any mutation 66 20 TMB quintile 5 0.14 -1.25 1.29 1611.89 1.00 498 63 17 3 TRUE 0.08
colorectal cancer KRAS_13 POLD1 Any mutation 16 83 TMB quintile 6 -0.12 -1.19 0.88 1394.84 1.00 65 8 75 8 TRUE 0.08
colorectal cancer KRAS_13 POLD1 Any mutation 82 103 TMB overall 0.06 -2.79 3.02 1336.61 1.00 563 71 92 11 TRUE 0.01
colorectal cancer KRAS_13 AMER1 Any mutation 23 13 TMB quintile 3 0.80 -0.62 2.15 1441.32 1.00 453 21 11 2 FALSE 0.59
colorectal cancer KRAS_13 AMER1 Any mutation 59 38 TMB quintile 4 -0.63 -2.23 0.60 1562.62 1.00 697 58 37 1 FALSE 0.42
colorectal cancer KRAS_13 AMER1 Any mutation 76 62 TMB quintile 5 0.09 -0.67 0.84 1579.64 1.00 496 68 54 8 FALSE 0.09
colorectal cancer KRAS_13 AMER1 Any mutation 20 55 TMB quintile 6 1.25 0.39 2.23 1371.63 1.00 91 7 42 13 FALSE 2.06
colorectal cancer KRAS_13 AMER1 Any mutation 178 168 TMB overall 0.38 -0.90 1.64 1587.93 1.00 1737 154 144 24 FALSE 0.26
melanoma RAS_61 SPEN Any mutation 136 55 TMB quintile 5 -0.27 -0.90 0.32 1422.20 1.00 229 120 39 16 FALSE 0.42
melanoma RAS_61 SPEN Any mutation 139 111 TMB overall -0.13 -2.94 3.09 1543.07 1.00 266 121 93 18 FALSE 0.03
melanoma RAS_61 KMT2C Any mutation 131 85 TMB quintile 5 -0.44 -1.03 0.07 1526.23 1.00 195 108 62 23 FALSE 0.94
melanoma RAS_61 KMT2C Any mutation 134 139 TMB overall -1.67 -5.43 1.64 1249.81 1.00 220 111 116 23 FALSE 0.47
melanoma RAS_61 TP53 Any mutation 11 14 TMB quintile 3 -1.56 -4.18 0.24 1448.25 1.00 87 11 14 0 TRUE 0.76
melanoma RAS_61 TP53 Any mutation 17 16 TMB quintile 4 0.20 -1.12 1.44 1525.80 1.00 76 13 12 4 TRUE 0.12
melanoma RAS_61 TP53 Any mutation 136 119 TMB quintile 5 -0.37 -0.85 0.08 1576.28 1.00 187 103 86 33 TRUE 0.88
melanoma RAS_61 TP53 Any mutation 167 201 TMB overall -0.73 -2.28 0.76 1538.58 1.00 377 129 163 38 TRUE 0.48
melanoma RAS_61 ATRX Any mutation 138 58 TMB quintile 5 -0.11 -0.70 0.49 1432.07 1.00 232 119 39 19 TRUE 0.14
melanoma RAS_61 ATRX Any mutation 141 88 TMB overall -1.16 -5.06 2.03 1430.01 1.00 283 122 69 19 TRUE 0.31
melanoma RAS_61 PTPRD Any mutation 145 147 TMB quintile 5 -0.26 -0.73 0.16 1522.21 1.00 181 101 103 44 FALSE 0.61
melanoma RAS_61 PTPRD Any mutation 6 115 TMB quintile 6 1.18 -1.10 5.44 1281.26 1.00 21 0 109 6 FALSE 0.31
melanoma RAS_61 PTPRD Any mutation 151 262 TMB overall 0.36 -2.74 3.95 1404.70 1.00 202 101 212 50 FALSE 0.08
melanoma RAS_61 PIK3C2G Any mutation 135 99 TMB quintile 5 0.27 -0.22 0.75 1512.85 1.00 197 96 60 39 FALSE 0.57
melanoma RAS_61 PIK3C2G Any mutation 139 184 TMB overall -0.07 -2.86 2.81 1290.36 1.00 216 97 142 42 FALSE 0.02
melanoma RAS_61 PTPRT Any mutation 147 200 TMB quintile 5 0.02 -0.38 0.39 1575.43 1.00 167 81 134 66 FALSE 0.04
melanoma RAS_61 PTPRT Any mutation 8 153 TMB quintile 6 0.88 -1.58 4.90 1292.53 1.00 13 0 145 8 FALSE 0.21
melanoma RAS_61 PTPRT Any mutation 155 353 TMB overall 0.37 -2.72 4.00 1165.06 1.00 180 81 279 74 FALSE 0.08
melanoma RAS_61 ALK Any mutation 137 76 TMB quintile 5 0.01 -0.54 0.53 1667.59 1.00 218 111 50 26 TRUE 0.02
melanoma RAS_61 ALK Any mutation 141 127 TMB overall 0.15 -2.46 2.92 1369.48 1.00 252 112 98 29 TRUE 0.04
melanoma RAS_61 IKZF1 Any mutation 137 57 TMB quintile 5 -0.25 -0.87 0.34 1602.30 1.00 229 120 40 17 TRUE 0.38
melanoma RAS_61 IKZF1 Any mutation 140 101 TMB overall -0.63 -3.30 2.07 1211.30 1.00 269 122 83 18 TRUE 0.19
melanoma RAS_61 FAT1 Any mutation 137 86 TMB quintile 5 -0.34 -0.86 0.17 1468.86 1.00 209 113 62 24 FALSE 0.70
melanoma RAS_61 FAT1 Any mutation 140 136 TMB overall -0.18 -2.85 2.71 1213.19 1.00 247 114 110 26 FALSE 0.05
melanoma RAS_61 KMT2A Any mutation 138 69 TMB quintile 5 -0.12 -0.69 0.44 1428.86 1.00 225 116 47 22 FALSE 0.16
melanoma RAS_61 KMT2A Any mutation 141 131 TMB overall -0.20 -3.03 3.10 1484.45 1.00 256 117 107 24 FALSE 0.05
melanoma RAS_61 PAK7 Any mutation 135 135 TMB quintile 5 -0.40 -0.87 0.02 1323.94 1.00 167 97 97 38 FALSE 1.10
melanoma RAS_61 PAK7 Any mutation 140 210 TMB overall -0.26 -2.62 2.57 1424.41 1.00 187 98 168 42 FALSE 0.07
melanoma RAS_61 TERT Any mutation 11 17 TMB quintile 2 2.45 1.18 3.76 1275.78 1.00 103 4 10 7 TRUE 3.72
melanoma RAS_61 TERT Any mutation 11 29 TMB quintile 3 0.98 -0.24 2.20 1410.62 1.00 77 6 24 5 TRUE 0.94
melanoma RAS_61 TERT Any mutation 19 57 TMB quintile 4 1.18 0.20 2.20 1292.66 1.00 45 5 43 14 TRUE 1.60
melanoma RAS_61 TERT Any mutation 149 396 TMB quintile 5 0.72 0.12 1.39 1478.96 1.00 44 13 260 136 TRUE 1.57
melanoma RAS_61 TERT Any mutation 194 605 TMB overall 1.21 -0.27 2.77 1325.70 1.00 281 28 439 166 TRUE 0.96
melanoma RAS_61 NOTCH3 Any mutation 136 67 TMB quintile 5 -0.45 -1.08 0.12 1485.03 1.00 217 118 49 18 TRUE 0.84
melanoma RAS_61 NOTCH3 Any mutation 139 124 TMB overall -1.66 -5.48 1.68 1386.07 1.00 249 121 106 18 TRUE 0.47
melanoma RAS_61 NOTCH4 Any mutation 132 81 TMB quintile 5 -0.06 -0.59 0.44 1618.19 1.00 202 105 54 27 TRUE 0.08
melanoma RAS_61 NOTCH4 Any mutation 136 145 TMB overall -0.11 -2.87 3.01 1514.35 1.00 223 106 115 30 TRUE 0.03
melanoma RAS_61 CDKN2A Any mutation 140 80 TMB quintile 5 0.08 -0.42 0.59 1421.26 1.00 215 111 51 29 TRUE 0.12
melanoma RAS_61 CDKN2A Any mutation 143 114 TMB overall 0.15 -2.33 2.86 1506.42 1.00 252 112 83 31 TRUE 0.04
melanoma RAS_61 KMT2D Any mutation 144 112 TMB quintile 5 0.11 -0.32 0.55 1363.43 1.00 207 104 72 40 FALSE 0.21
melanoma RAS_61 KMT2D Any mutation 7 91 TMB quintile 6 1.75 -0.54 5.67 1093.87 1.00 28 0 84 7 FALSE 0.54
melanoma RAS_61 KMT2D Any mutation 151 203 TMB overall 0.74 -2.72 4.47 1472.77 1.00 235 104 156 47 FALSE 0.17
colorectal cancer RAS_61 APC Any mutation 24 428 TMB quintile 3 -0.48 -1.29 0.38 1533.50 1.00 148 10 414 14 TRUE 0.59
colorectal cancer RAS_61 APC Any mutation 50 966 TMB quintile 4 0.66 -0.22 1.64 1527.26 1.00 149 3 919 47 TRUE 0.78
colorectal cancer RAS_61 APC Any mutation 49 822 TMB quintile 5 0.77 -0.07 1.72 1507.92 1.00 148 3 776 46 TRUE 1.03
melanoma RAS_61 APC Any mutation 136 67 TMB quintile 5 -0.46 -1.11 0.12 1530.68 1.00 224 119 50 17 TRUE 0.88
colorectal cancer RAS_61 APC Any mutation 126 2519 TMB overall -0.26 -1.48 0.79 1599.15 1.00 557 19 2412 107 TRUE 0.19
melanoma RAS_61 APC Any mutation 139 117 TMB overall -0.24 -3.04 2.89 1423.29 1.00 261 120 98 19 TRUE 0.06
melanoma RAS_61 ARID2 Any mutation 143 83 TMB quintile 5 0.21 -0.29 0.71 1464.57 1.00 222 111 51 32 FALSE 0.38
melanoma RAS_61 ARID2 Any mutation 146 136 TMB overall -0.31 -3.02 2.40 1440.30 1.00 267 113 103 33 FALSE 0.09
melanoma RAS_61 EPHA3 Any mutation 139 57 TMB quintile 5 0.63 0.06 1.19 1219.12 1.00 237 112 30 27 FALSE 1.55
melanoma RAS_61 EPHA3 Any mutation 142 102 TMB overall 0.40 -2.42 3.53 1322.20 1.00 274 113 73 29 FALSE 0.11
melanoma RAS_61 KDR Any mutation 135 64 TMB quintile 5 -0.25 -0.87 0.33 1533.47 1.00 220 116 45 19 TRUE 0.39
melanoma RAS_61 KDR Any mutation 139 126 TMB overall -0.50 -3.16 2.25 1413.88 1.00 249 118 105 21 TRUE 0.15
melanoma RAS_61 NTRK3 Any mutation 140 58 TMB quintile 5 -0.32 -0.93 0.31 1354.34 1.00 224 123 41 17 FALSE 0.51
melanoma RAS_61 NTRK3 Any mutation 143 100 TMB overall -0.58 -3.56 2.34 1536.69 1.00 262 125 82 18 FALSE 0.17
melanoma RAS_61 GRIN2A Any mutation 144 166 TMB quintile 5 -0.57 -1.02 -0.14 1530.87 1.00 171 102 124 42 FALSE 2.01
melanoma RAS_61 GRIN2A Any mutation 6 124 TMB quintile 6 -0.52 -2.19 1.51 1505.50 1.00 17 1 119 5 FALSE 0.24
melanoma RAS_61 GRIN2A Any mutation 150 290 TMB overall -0.49 -3.07 2.63 1226.64 1.00 188 103 243 47 FALSE 0.13
melanoma RAS_61 ERBB4 Any mutation 139 92 TMB quintile 5 -0.28 -0.78 0.21 1533.85 1.00 206 112 65 27 TRUE 0.56
melanoma RAS_61 ERBB4 Any mutation 143 181 TMB overall -0.41 -3.43 2.50 1577.19 1.00 225 113 151 30 TRUE 0.11
melanoma RAS_61 NF1 Any mutation 11 13 TMB quintile 3 -0.93 -3.18 1.13 1579.27 1.00 88 10 12 1 TRUE 0.41
melanoma RAS_61 NF1 Any mutation 17 11 TMB quintile 4 -2.37 -5.84 -0.09 1710.50 1.00 79 17 11 0 TRUE 1.00
melanoma RAS_61 NF1 Any mutation 137 162 TMB quintile 5 -1.59 -2.14 -1.07 1472.23 1.00 168 117 142 20 TRUE 8.39
melanoma RAS_61 NF1 Any mutation 170 286 TMB overall -1.25 -3.26 0.85 1499.92 1.00 347 144 260 26 TRUE 0.66
melanoma RAS_61 FLT1 Any mutation 137 60 TMB quintile 5 -0.14 -0.74 0.43 1476.51 1.00 223 118 41 19 FALSE 0.20
melanoma RAS_61 FLT1 Any mutation 142 116 TMB overall 0.19 -2.45 3.22 1480.97 1.00 257 119 93 23 FALSE 0.05
melanoma RAS_61 ROS1 Any mutation 140 139 TMB quintile 5 -0.28 -0.72 0.15 1471.83 1.00 187 100 99 40 TRUE 0.68
melanoma RAS_61 ROS1 Any mutation 144 242 TMB overall 0.20 -3.13 3.97 1431.26 1.00 210 100 198 44 TRUE 0.04
melanoma RAS_61 PIK3CG Any mutation 135 43 TMB quintile 5 -0.48 -1.19 0.19 1346.91 1.00 232 124 32 11 FALSE 0.74
melanoma RAS_61 PIK3CG Any mutation 139 99 TMB overall -0.04 -3.12 3.27 1461.63 1.00 268 125 85 14 FALSE 0.01
melanoma RAS_61 BRAF Any mutation 10 16 TMB quintile 2 -3.09 -5.95 -0.83 1451.55 1.00 96 10 16 0 TRUE 1.84
melanoma RAS_61 BRAF Any mutation 11 27 TMB quintile 3 -3.29 -5.95 -1.19 1331.11 1.00 72 11 27 0 TRUE 2.13
melanoma RAS_61 BRAF Any mutation 17 53 TMB quintile 4 -3.11 -5.06 -1.71 1509.95 1.00 37 16 52 1 TRUE 3.48
melanoma RAS_61 BRAF Any mutation 138 170 TMB quintile 5 -2.21 -2.79 -1.66 1466.75 1.00 124 121 153 17 TRUE 14.56
melanoma RAS_61 BRAF Any mutation 179 283 TMB overall -2.92 -4.66 -1.52 1404.77 1.00 379 161 265 18 TRUE 3.52
melanoma RAS_61 CARD11 Any mutation 137 63 TMB quintile 5 -0.60 -1.24 -0.01 1478.52 1.00 221 122 48 15 FALSE 1.24
melanoma RAS_61 CARD11 Any mutation 140 108 TMB overall -0.79 -3.52 2.12 1361.07 1.00 255 124 92 16 FALSE 0.24
melanoma RAS_61 TP63 Any mutation 134 95 TMB quintile 5 0.12 -0.37 0.64 1316.90 1.00 196 99 60 35 FALSE 0.21
melanoma RAS_61 TP63 Any mutation 137 164 TMB overall -0.28 -3.50 2.94 1452.89 1.00 212 100 127 37 FALSE 0.07
melanoma RAS_61 ZFHX3 Any mutation 132 62 TMB quintile 5 -0.18 -0.80 0.42 1448.70 1.00 216 113 43 19 FALSE 0.27
melanoma RAS_61 ZFHX3 Any mutation 135 140 TMB overall -0.26 -3.33 2.87 1563.38 1.00 251 114 119 21 FALSE 0.07
melanoma RAS_61 PREX2 Any mutation 87 89 TMB quintile 5 0.18 -0.36 0.77 1372.14 1.00 103 53 55 34 FALSE 0.27
melanoma RAS_61 PREX2 Any mutation 91 165 TMB overall 0.43 -2.84 4.17 1321.44 1.00 116 53 127 38 FALSE 0.10
melanoma RAS_61 EPHA7 Any mutation 132 89 TMB quintile 5 -0.19 -0.71 0.32 1329.84 1.00 201 105 62 27 FALSE 0.33
melanoma RAS_61 EPHA7 Any mutation 135 152 TMB overall -0.29 -2.87 2.50 1394.92 1.00 230 106 123 29 FALSE 0.08
melanoma NRAS_61 SPEN Any mutation 132 55 TMB quintile 5 -0.42 -1.06 0.24 1485.25 1.00 231 118 41 14 FALSE 0.68
melanoma NRAS_61 SPEN Any mutation 135 111 TMB overall -0.24 -3.32 3.29 1456.32 1.00 268 119 95 16 FALSE 0.06
melanoma NRAS_61 KMT2C Any mutation 127 85 TMB quintile 5 -0.40 -0.95 0.14 1172.21 1.00 199 104 62 23 FALSE 0.82
melanoma NRAS_61 KMT2C Any mutation 130 139 TMB overall -1.72 -5.64 1.48 1491.44 1.00 224 107 116 23 FALSE 0.48
melanoma NRAS_61 TP53 Any mutation 10 14 TMB quintile 3 -1.51 -4.20 0.34 1458.67 1.00 88 10 14 0 TRUE 0.72
melanoma NRAS_61 TP53 Any mutation 16 16 TMB quintile 4 -0.18 -1.54 1.09 1548.56 1.00 76 13 13 3 TRUE 0.10
melanoma NRAS_61 TP53 Any mutation 132 119 TMB quintile 5 -0.37 -0.83 0.07 1502.46 1.00 190 100 87 32 TRUE 0.94
melanoma NRAS_61 TP53 Any mutation 161 201 TMB overall -0.81 -2.30 0.55 1310.07 1.00 381 125 165 36 TRUE 0.55
melanoma NRAS_61 ATRX Any mutation 133 58 TMB quintile 5 -0.21 -0.85 0.38 1596.39 1.00 235 116 41 17 TRUE 0.31
melanoma NRAS_61 ATRX Any mutation 136 88 TMB overall -1.25 -5.23 1.67 1664.05 1.00 286 119 71 17 TRUE 0.34
melanoma NRAS_61 PTPRD Any mutation 141 147 TMB quintile 5 -0.20 -0.61 0.24 1423.96 1.00 185 97 103 44 FALSE 0.45
melanoma NRAS_61 PTPRD Any mutation 6 115 TMB quintile 6 1.17 -1.23 5.55 1431.78 1.00 21 0 109 6 FALSE 0.29
melanoma NRAS_61 PTPRD Any mutation 147 262 TMB overall 0.40 -2.92 4.52 1337.34 1.00 206 97 212 50 FALSE 0.08
melanoma NRAS_61 PIK3C2G Any mutation 130 99 TMB quintile 5 0.19 -0.29 0.66 1456.34 1.00 199 94 63 36 FALSE 0.35
melanoma NRAS_61 PIK3C2G Any mutation 134 184 TMB overall -0.12 -3.04 3.19 1458.03 1.00 218 95 145 39 FALSE 0.03
melanoma NRAS_61 PTPRT Any mutation 143 200 TMB quintile 5 0.01 -0.41 0.40 1581.67 1.00 169 79 136 64 FALSE 0.02
melanoma NRAS_61 PTPRT Any mutation 8 153 TMB quintile 6 0.99 -1.61 5.45 1362.41 1.00 13 0 145 8 FALSE 0.22
melanoma NRAS_61 PTPRT Any mutation 151 353 TMB overall 0.44 -2.45 4.27 1607.93 1.00 182 79 281 72 FALSE 0.10
melanoma NRAS_61 ALK Any mutation 133 76 TMB quintile 5 -0.07 -0.63 0.46 1416.61 1.00 220 109 52 24 TRUE 0.10
melanoma NRAS_61 ALK Any mutation 137 127 TMB overall 0.07 -2.63 3.03 1620.60 1.00 254 110 100 27 TRUE 0.02
melanoma NRAS_61 IKZF1 Any mutation 133 57 TMB quintile 5 -0.30 -0.96 0.28 1286.90 1.00 232 117 41 16 TRUE 0.48
melanoma NRAS_61 IKZF1 Any mutation 136 101 TMB overall -0.60 -3.60 2.27 1427.15 1.00 272 119 84 17 TRUE 0.18
melanoma NRAS_61 FAT1 Any mutation 133 86 TMB quintile 5 -0.36 -0.90 0.14 1490.20 1.00 212 110 63 23 FALSE 0.76
melanoma NRAS_61 FAT1 Any mutation 136 136 TMB overall -0.21 -2.78 2.44 1443.50 1.00 250 111 111 25 FALSE 0.06
melanoma NRAS_61 KMT2A Any mutation 134 69 TMB quintile 5 -0.06 -0.62 0.50 1458.74 1.00 229 112 47 22 FALSE 0.08
melanoma NRAS_61 KMT2A Any mutation 137 131 TMB overall -0.20 -3.48 2.72 1439.06 1.00 260 113 107 24 FALSE 0.05
melanoma NRAS_61 PAK7 Any mutation 131 135 TMB quintile 5 -0.44 -0.91 0.04 1403.52 1.00 169 95 99 36 FALSE 1.18
melanoma NRAS_61 PAK7 Any mutation 136 210 TMB overall -0.31 -2.80 2.43 1440.01 1.00 189 96 170 40 FALSE 0.09
melanoma NRAS_61 TERT Any mutation 11 17 TMB quintile 2 2.52 1.21 3.90 1415.35 1.00 103 4 10 7 TRUE 3.84
melanoma NRAS_61 TERT Any mutation 10 29 TMB quintile 3 1.19 -0.03 2.45 1346.41 1.00 78 5 24 5 TRUE 1.23
melanoma NRAS_61 TERT Any mutation 18 57 TMB quintile 4 1.42 0.37 2.64 1336.79 1.00 46 4 43 14 TRUE 1.85
melanoma NRAS_61 TERT Any mutation 145 396 TMB quintile 5 0.68 0.06 1.35 1686.62 1.00 44 13 264 132 TRUE 1.35
melanoma NRAS_61 TERT Any mutation 188 605 TMB overall 1.28 -0.24 2.90 1520.52 1.00 283 26 443 162 TRUE 1.00
melanoma NRAS_61 NOTCH3 Any mutation 132 67 TMB quintile 5 -0.40 -0.99 0.18 1458.61 1.00 221 114 49 18 TRUE 0.73
melanoma NRAS_61 NOTCH3 Any mutation 135 124 TMB overall -1.66 -5.48 1.73 1648.44 1.00 253 117 106 18 TRUE 0.43
melanoma NRAS_61 NOTCH4 Any mutation 128 81 TMB quintile 5 -0.06 -0.59 0.45 1428.21 1.00 205 102 55 26 TRUE 0.09
melanoma NRAS_61 NOTCH4 Any mutation 132 145 TMB overall -0.12 -2.92 2.88 1389.49 1.00 226 103 116 29 TRUE 0.03
melanoma NRAS_61 CDKN2A Any mutation 136 80 TMB quintile 5 0.07 -0.42 0.54 1515.89 1.00 218 108 52 28 TRUE 0.12
melanoma NRAS_61 CDKN2A Any mutation 139 114 TMB overall 0.12 -2.54 2.90 1500.08 1.00 255 109 84 30 TRUE 0.03
melanoma NRAS_61 KMT2D Any mutation 140 112 TMB quintile 5 0.16 -0.30 0.61 1395.77 1.00 211 100 72 40 FALSE 0.29
melanoma NRAS_61 KMT2D Any mutation 7 91 TMB quintile 6 1.91 -0.48 6.65 1371.49 1.00 28 0 84 7 FALSE 0.52
melanoma NRAS_61 KMT2D Any mutation 147 203 TMB overall 0.89 -2.54 4.64 1447.63 1.00 239 100 156 47 FALSE 0.21
melanoma NRAS_61 APC Any mutation 132 67 TMB quintile 5 -0.50 -1.10 0.05 1349.36 1.00 227 116 51 16 TRUE 1.04
melanoma NRAS_61 APC Any mutation 135 117 TMB overall -0.27 -2.85 2.61 1469.37 1.00 264 117 99 18 TRUE 0.07
melanoma NRAS_61 ARID2 Any mutation 139 83 TMB quintile 5 0.26 -0.22 0.75 1304.59 1.00 226 107 51 32 FALSE 0.53
melanoma NRAS_61 ARID2 Any mutation 142 136 TMB overall -0.32 -3.35 2.46 1585.82 1.00 271 109 103 33 FALSE 0.08
melanoma NRAS_61 EPHA3 Any mutation 134 57 TMB quintile 5 0.44 -0.10 0.99 1550.45 1.00 239 110 33 24 FALSE 0.91
melanoma NRAS_61 EPHA3 Any mutation 137 102 TMB overall 0.32 -2.52 3.51 1362.93 1.00 276 111 76 26 FALSE 0.08
melanoma NRAS_61 KDR Any mutation 131 64 TMB quintile 5 -0.21 -0.78 0.33 1509.01 1.00 224 112 45 19 TRUE 0.34
melanoma NRAS_61 KDR Any mutation 135 126 TMB overall -0.49 -3.09 2.22 1429.10 1.00 253 114 105 21 TRUE 0.15
melanoma NRAS_61 NTRK3 Any mutation 136 58 TMB quintile 5 -0.26 -0.89 0.34 1533.65 1.00 228 119 41 17 FALSE 0.40
melanoma NRAS_61 NTRK3 Any mutation 139 100 TMB overall -0.52 -3.19 2.21 1590.03 1.00 266 121 82 18 FALSE 0.15
melanoma NRAS_61 GRIN2A Any mutation 140 166 TMB quintile 5 -0.60 -1.05 -0.18 1462.16 1.00 173 100 126 40 FALSE 2.25
melanoma NRAS_61 GRIN2A Any mutation 6 124 TMB quintile 6 -0.57 -2.24 1.37 1478.78 1.00 17 1 119 5 FALSE 0.27
melanoma NRAS_61 GRIN2A Any mutation 146 290 TMB overall -0.52 -3.28 2.57 1485.43 1.00 190 101 245 45 FALSE 0.15
melanoma NRAS_61 ERBB4 Any mutation 135 92 TMB quintile 5 -0.36 -0.87 0.11 1234.25 1.00 208 110 67 25 TRUE 0.82
melanoma NRAS_61 ERBB4 Any mutation 139 181 TMB overall -0.45 -3.38 2.49 1520.44 1.00 227 111 153 28 TRUE 0.12
melanoma NRAS_61 NF1 Any mutation 10 13 TMB quintile 3 -0.84 -3.26 1.04 1642.44 1.00 89 9 12 1 TRUE 0.35
melanoma NRAS_61 NF1 Any mutation 16 11 TMB quintile 4 -2.35 -5.63 0.00 1502.44 1.00 80 16 11 0 TRUE 0.88
melanoma NRAS_61 NF1 Any mutation 133 162 TMB quintile 5 -1.60 -2.11 -1.10 991.41 1.00 171 114 143 19 TRUE 9.13
melanoma NRAS_61 NF1 Any mutation 164 286 TMB overall -1.19 -3.30 0.71 1351.09 1.00 352 139 261 25 TRUE 0.58
melanoma NRAS_61 FLT1 Any mutation 133 60 TMB quintile 5 -0.17 -0.77 0.45 1412.85 1.00 226 115 42 18 FALSE 0.23
melanoma NRAS_61 FLT1 Any mutation 138 116 TMB overall 0.13 -2.65 3.05 1447.70 1.00 260 116 94 22 FALSE 0.03
melanoma NRAS_61 ROS1 Any mutation 136 139 TMB quintile 5 -0.32 -0.75 0.09 1413.68 1.00 189 98 101 38 TRUE 0.86
melanoma NRAS_61 ROS1 Any mutation 140 242 TMB overall 0.24 -3.12 3.77 1348.72 1.00 212 98 200 42 TRUE 0.05
melanoma NRAS_61 PIK3CG Any mutation 131 43 TMB quintile 5 -0.41 -1.16 0.33 1095.14 1.00 236 120 32 11 FALSE 0.57
melanoma NRAS_61 PIK3CG Any mutation 135 99 TMB overall -0.10 -3.07 2.87 1577.71 1.00 272 121 85 14 FALSE 0.02
melanoma NRAS_61 BRAF Any mutation 10 16 TMB quintile 2 -3.11 -5.92 -0.97 1580.64 1.00 96 10 16 0 TRUE 1.85
melanoma NRAS_61 BRAF Any mutation 10 27 TMB quintile 3 -3.17 -5.80 -1.10 1752.01 1.00 73 10 27 0 TRUE 2.16
melanoma NRAS_61 BRAF Any mutation 16 53 TMB quintile 4 -3.02 -4.96 -1.56 1418.15 1.00 38 15 52 1 TRUE 3.18
melanoma NRAS_61 BRAF Any mutation 134 170 TMB quintile 5 -2.22 -2.83 -1.69 1491.15 1.00 127 118 154 16 TRUE 13.66
melanoma NRAS_61 BRAF Any mutation 173 283 TMB overall -2.88 -4.58 -1.49 1622.44 1.00 384 156 266 17 TRUE 3.58
melanoma NRAS_61 CARD11 Any mutation 133 63 TMB quintile 5 -0.57 -1.21 0.06 1547.65 1.00 225 118 48 15 FALSE 1.15
melanoma NRAS_61 CARD11 Any mutation 136 108 TMB overall -0.75 -3.57 2.15 1477.46 1.00 259 120 92 16 FALSE 0.23
melanoma NRAS_61 TP63 Any mutation 130 95 TMB quintile 5 0.12 -0.36 0.58 1390.02 1.00 199 96 61 34 FALSE 0.20
melanoma NRAS_61 TP63 Any mutation 133 164 TMB overall -0.34 -3.20 2.83 1524.66 1.00 215 97 128 36 FALSE 0.09
melanoma NRAS_61 ZFHX3 Any mutation 127 62 TMB quintile 5 -0.31 -0.93 0.23 1421.27 1.00 219 110 45 17 FALSE 0.52
melanoma NRAS_61 ZFHX3 Any mutation 130 140 TMB overall -0.33 -3.13 2.68 1481.72 1.00 254 111 121 19 FALSE 0.08
melanoma NRAS_61 PREX2 Any mutation 85 89 TMB quintile 5 0.24 -0.30 0.77 1423.70 1.00 105 51 55 34 FALSE 0.41
melanoma NRAS_61 PREX2 Any mutation 89 165 TMB overall 0.48 -2.37 4.29 1434.59 1.00 118 51 127 38 FALSE 0.11
melanoma NRAS_61 EPHA7 Any mutation 128 89 TMB quintile 5 -0.28 -0.84 0.22 1684.73 1.00 203 103 64 25 FALSE 0.55
melanoma NRAS_61 EPHA7 Any mutation 131 152 TMB overall -0.34 -3.11 2.44 1275.83 1.00 232 104 125 27 FALSE 0.10
colorectal cancer RAS_12-61 SPEN Any mutation 14 21 Signature 10 -1.26 -2.62 -0.12 1535.12 1.00 14 11 18 3 FALSE 1.34
colorectal cancer RAS_12-61 SPEN Any mutation 173 18 Signature 15 -1.41 -2.60 -0.45 1436.70 1.00 202 170 15 3 FALSE 2.03
colorectal cancer RAS_12-61 SPEN Any mutation 369 38 Signature 1A -0.34 -1.00 0.31 1412.25 1.00 459 354 23 15 FALSE 0.49
colorectal cancer RAS_12-61 SPEN Any mutation 125 61 Signature 6 -1.11 -1.77 -0.48 1215.27 1.00 153 113 49 12 FALSE 3.06
melanoma RAS_12-61 SPEN Any mutation 153 105 Signature 7 -0.29 -0.94 0.20 235.59 1.00 249 124 76 29 FALSE 0.53
non-small cell lung cancer RAS_12-61 SPEN Any mutation 86 39 Signature 2 -4.13 -9.82 -1.47 1514.44 1.00 226 86 39 0 FALSE 1.29
non-small cell lung cancer RAS_12-61 SPEN Any mutation 276 24 Signature 4 -0.25 -1.15 0.59 1474.20 1.00 414 267 15 9 FALSE 0.23
uterine cancer RAS_12-61 SPEN Any mutation 7 38 Signature 10 0.74 -0.45 2.10 1346.00 1.00 22 1 32 6 FALSE 0.60
uterine cancer RAS_12-61 SPEN Any mutation 27 13 Signature 15 0.64 -0.46 1.69 1405.33 1.00 76 22 8 5 FALSE 0.63
uterine cancer RAS_12-61 SPEN Any mutation 44 21 Signature 1A 0.02 -1.13 0.97 1387.75 1.00 161 40 17 4 FALSE 0.02
uterine cancer RAS_12-61 SPEN Any mutation 18 21 Signature 6 0.74 -0.36 1.76 1124.59 1.00 70 12 15 6 FALSE 0.77
colorectal cancer RAS_12-61 SPEN Any mutation 681 138 Signature overall -1.03 -2.14 0.13 1506.08 1.00 828 648 105 33 FALSE 1.18
melanoma RAS_12-61 SPEN Any mutation 153 105 Signature overall -0.29 -4.47 3.38 1407.24 1.00 249 124 76 29 FALSE 0.06
non-small cell lung cancer RAS_12-61 SPEN Any mutation 362 63 Signature overall -2.00 -6.00 1.25 1443.06 1.00 640 353 54 9 FALSE 0.59
uterine cancer RAS_12-61 SPEN Any mutation 96 93 Signature overall 0.54 -0.64 1.69 1638.83 1.00 329 75 72 21 FALSE 0.44
colorectal cancer RAS_12-61 KMT2C Any mutation 17 32 Signature 10 -1.08 -2.24 -0.13 1518.64 1.00 11 11 26 6 FALSE 1.30
colorectal cancer RAS_12-61 KMT2C Any mutation 169 22 Signature 15 -0.49 -1.38 0.30 1526.87 1.00 201 161 14 8 FALSE 0.61
colorectal cancer RAS_12-61 KMT2C Any mutation 362 60 Signature 1A -0.23 -0.73 0.30 1376.47 1.00 438 338 36 24 FALSE 0.41
colorectal cancer RAS_12-61 KMT2C Any mutation 119 65 Signature 6 -0.75 -1.35 -0.17 1376.96 1.00 147 103 49 16 FALSE 1.85
melanoma RAS_12-61 KMT2C Any mutation 16 11 Signature 11 0.12 -0.90 1.53 1101.29 1.00 33 11 6 5 FALSE 0.07
melanoma RAS_12-61 KMT2C Any mutation 146 126 Signature 7 -0.50 -0.97 -0.07 1326.63 1.00 206 116 96 30 FALSE 1.49
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 15 22 Signature 13 0.22 -0.74 1.18 1643.71 1.00 68 10 17 5 FALSE 0.18
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 87 40 Signature 2 0.17 -0.49 0.81 1563.97 1.00 212 74 27 13 FALSE 0.21
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 55 13 Signature 3 -0.59 -1.82 0.35 1337.17 1.00 176 54 12 1 FALSE 0.58
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 276 76 Signature 4 -0.33 -0.80 0.15 1480.59 1.00 380 252 52 24 FALSE 0.77
uterine cancer RAS_12-61 KMT2C Any mutation 24 17 Signature 15 -0.56 -1.83 0.61 1355.79 1.00 72 21 14 3 FALSE 0.42
uterine cancer RAS_12-61 KMT2C Any mutation 42 20 Signature 1A -1.02 -2.51 0.24 1489.72 1.00 146 40 18 2 FALSE 0.88
uterine cancer RAS_12-61 KMT2C Any mutation 18 23 Signature 6 -0.66 -1.95 0.45 1308.80 1.00 61 15 20 3 FALSE 0.56
colorectal cancer RAS_12-61 KMT2C Any mutation 667 179 Signature overall -0.63 -1.80 0.57 1357.78 1.00 797 613 125 54 FALSE 0.56
melanoma RAS_12-61 KMT2C Any mutation 162 137 Signature overall -0.19 -1.41 1.44 1115.75 1.00 239 127 102 35 FALSE 0.10
non-small cell lung cancer RAS_12-61 KMT2C Any mutation 433 151 Signature overall -0.13 -0.99 0.70 1535.16 1.00 836 390 108 43 FALSE 0.12
uterine cancer RAS_12-61 KMT2C Any mutation 88 118 Signature overall -0.85 -2.08 0.49 1339.49 1.00 297 78 108 10 FALSE 0.69
cancer of unknown primary RAS_12-61 TP53 Any mutation 14 11 Signature 11 -0.25 -1.22 0.77 1390.92 1.00 6 7 4 7 TRUE 0.21
cancer of unknown primary RAS_12-61 TP53 Any mutation 14 28 Signature 15 -0.09 -0.96 0.90 1410.66 1.00 18 4 18 10 TRUE 0.07
cancer of unknown primary RAS_12-61 TP53 Any mutation 40 66 Signature 1A -0.60 -1.22 0.04 1512.80 1.00 33 22 48 18 TRUE 1.19
cancer of unknown primary RAS_12-61 TP53 Any mutation 10 31 Signature 2 -0.80 -1.74 0.17 1406.18 1.00 20 6 27 4 TRUE 1.07
cancer of unknown primary RAS_12-61 TP53 Any mutation 8 18 Signature 3 -0.90 -2.03 0.06 1487.35 1.00 4 5 15 3 TRUE 1.07
cancer of unknown primary RAS_12-61 TP53 Any mutation 25 70 Signature 4 -0.95 -1.76 -0.20 1298.74 1.00 8 11 56 14 TRUE 1.71
cancer of unknown primary RAS_12-61 TP53 Any mutation 6 22 Signature 6 -0.42 -1.39 0.65 1425.68 1.00 7 1 17 5 TRUE 0.38
colorectal cancer RAS_12-61 TP53 Any mutation 15 32 Signature 10 -0.90 -1.32 -0.50 1387.84 1.00 5 4 21 11 TRUE 4.62
colorectal cancer RAS_12-61 TP53 Any mutation 25 28 Signature 11 -0.75 -1.14 -0.28 1442.32 1.00 1 8 11 17 TRUE 3.28
colorectal cancer RAS_12-61 TP53 Any mutation 179 311 Signature 15 -0.91 -1.23 -0.59 1350.90 1.00 35 62 194 117 TRUE 8.07
colorectal cancer RAS_12-61 TP53 Any mutation 16 36 Signature 17 -0.94 -1.39 -0.52 1408.20 1.00 5 5 25 11 TRUE 4.82
colorectal cancer RAS_12-61 TP53 Any mutation 20 36 Signature 18 -1.00 -1.51 -0.63 1185.75 1.00 2 10 26 10 TRUE 5.23
colorectal cancer RAS_12-61 TP53 Any mutation 22 31 Signature 19 -1.00 -1.50 -0.60 1299.67 1.00 5 12 21 10 TRUE 4.96
colorectal cancer RAS_12-61 TP53 Any mutation 385 655 Signature 1A -0.91 -1.16 -0.67 1405.60 1.00 93 140 410 245 TRUE 12.30
colorectal cancer RAS_12-61 TP53 Any mutation 8 15 Signature 1B -0.93 -1.40 -0.50 1567.84 1.00 4 3 10 5 TRUE 4.62
colorectal cancer RAS_12-61 TP53 Any mutation 48 56 Signature 2 -0.93 -1.36 -0.52 1215.26 1.00 6 23 31 25 TRUE 5.21
colorectal cancer RAS_12-61 TP53 Any mutation 14 23 Signature 20 -0.90 -1.31 -0.50 1447.53 1.00 6 5 14 9 TRUE 4.75
colorectal cancer RAS_12-61 TP53 Any mutation 9 20 Signature 21 -0.99 -1.51 -0.58 1346.67 1.00 4 4 15 5 TRUE 4.48
colorectal cancer RAS_12-61 TP53 Any mutation 17 35 Signature 3 -0.93 -1.39 -0.53 1499.54 1.00 1 6 24 11 TRUE 4.99
colorectal cancer RAS_12-61 TP53 Any mutation 22 36 Signature 4 -0.90 -1.36 -0.49 1412.92 1.00 2 8 22 14 TRUE 4.64
colorectal cancer RAS_12-61 TP53 Any mutation 139 236 Signature 6 -0.74 -1.05 -0.34 1002.17 1.00 65 47 144 92 TRUE 4.13
colorectal cancer RAS_12-61 TP53 Any mutation 16 28 Signature 7 -0.95 -1.40 -0.56 1259.49 1.00 5 7 19 9 TRUE 4.98
colorectal cancer RAS_12-61 TP53 Any mutation 15 13 Signature 8 -0.86 -1.30 -0.38 1592.07 1.00 3 7 5 8 TRUE 3.96
colorectal cancer RAS_12-61 TP53 Any mutation 18 16 Signature R2 -0.78 -1.17 -0.33 1391.80 1.00 0 7 5 11 TRUE 3.52
melanoma RAS_12-61 TP53 Any mutation 16 14 Signature 11 -0.02 -0.84 0.94 1420.57 1.00 31 12 10 4 TRUE 0.01
melanoma RAS_12-61 TP53 Any mutation 16 14 Signature 1A 0.46 -0.49 1.76 1173.86 1.00 44 9 7 7 TRUE 0.35
melanoma RAS_12-61 TP53 Any mutation 152 150 Signature 7 -0.29 -0.70 0.13 1403.53 1.00 203 112 110 40 TRUE 0.76
non-small cell lung cancer RAS_12-61 TP53 Any mutation 23 12 Signature 11 -1.28 -2.12 -0.49 1168.55 1.00 13 19 8 4 TRUE 2.59
non-small cell lung cancer RAS_12-61 TP53 Any mutation 17 79 Signature 13 -0.84 -1.54 -0.12 1387.22 1.00 26 5 67 12 TRUE 1.61
non-small cell lung cancer RAS_12-61 TP53 Any mutation 21 36 Signature 14 -1.09 -1.81 -0.36 1639.01 1.00 12 12 27 9 TRUE 2.48
non-small cell lung cancer RAS_12-61 TP53 Any mutation 32 87 Signature 15 -1.12 -1.73 -0.51 1503.27 1.00 35 18 73 14 TRUE 3.31
non-small cell lung cancer RAS_12-61 TP53 Any mutation 12 39 Signature 16 -0.81 -1.60 0.00 1564.51 1.00 20 4 31 8 TRUE 1.32
non-small cell lung cancer RAS_12-61 TP53 Any mutation 19 29 Signature 17 -1.53 -2.30 -0.74 1536.58 1.00 5 14 24 5 TRUE 3.99
non-small cell lung cancer RAS_12-61 TP53 Any mutation 70 92 Signature 18 -1.04 -1.60 -0.53 1484.06 1.00 25 39 61 31 TRUE 4.07
non-small cell lung cancer RAS_12-61 TP53 Any mutation 16 31 Signature 19 -1.19 -1.99 -0.43 1487.05 1.00 24 11 26 5 TRUE 2.48
non-small cell lung cancer RAS_12-61 TP53 Any mutation 50 149 Signature 1A -0.94 -1.50 -0.40 1523.44 1.00 94 30 129 20 TRUE 3.14
non-small cell lung cancer RAS_12-61 TP53 Any mutation 7 18 Signature 1B -0.84 -1.64 0.06 1294.98 1.00 8 2 13 5 TRUE 1.23
non-small cell lung cancer RAS_12-61 TP53 Any mutation 88 223 Signature 2 -0.76 -1.18 -0.31 1696.30 1.00 83 41 176 47 TRUE 3.25
non-small cell lung cancer RAS_12-61 TP53 Any mutation 16 46 Signature 20 -1.28 -2.06 -0.53 1399.01 1.00 21 10 40 6 TRUE 3.05
non-small cell lung cancer RAS_12-61 TP53 Any mutation 11 37 Signature 21 -1.79 -2.67 -0.97 1454.84 1.00 19 10 36 1 TRUE 4.27
non-small cell lung cancer RAS_12-61 TP53 Any mutation 58 161 Signature 3 -1.06 -1.57 -0.54 1382.99 1.00 63 32 135 26 TRUE 4.27
non-small cell lung cancer RAS_12-61 TP53 Any mutation 279 522 Signature 4 -1.70 -2.04 -1.39 1368.51 1.00 74 152 395 127 TRUE 23.08
non-small cell lung cancer RAS_12-61 TP53 Any mutation 13 36 Signature 6 -1.22 -2.05 -0.47 1417.71 1.00 10 7 30 6 TRUE 2.61
non-small cell lung cancer RAS_12-61 TP53 Any mutation 27 71 Signature 7 -1.05 -1.71 -0.41 1534.27 1.00 27 14 58 13 TRUE 2.73
non-small cell lung cancer RAS_12-61 TP53 Any mutation 29 35 Signature 8 -1.03 -1.69 -0.33 1486.57 1.00 11 17 23 12 TRUE 2.45
non-small cell lung cancer RAS_12-61 TP53 Any mutation 158 85 Signature R2 -1.38 -1.91 -0.89 1479.99 1.00 12 109 36 49 TRUE 6.69
non-small cell lung cancer RAS_12-61 TP53 Any mutation 7 15 Signature R3 -1.52 -2.49 -0.56 1254.47 1.00 11 6 14 1 TRUE 2.79
non-small cell lung cancer RAS_12-61 TP53 Any mutation 23 57 Signature U1 -1.51 -2.28 -0.78 1449.71 1.00 38 18 52 5 TRUE 4.16
non-small cell lung cancer RAS_12-61 TP53 Any mutation 12 32 Signature U2 -1.47 -2.31 -0.67 1392.98 1.00 7 8 28 4 TRUE 3.38
pancreatic cancer RAS_12-61 TP53 Any mutation 117 94 Signature 11 2.50 1.92 3.12 1242.24 1.00 5 26 3 91 TRUE 15.65
pancreatic cancer RAS_12-61 TP53 Any mutation 113 98 Signature 15 2.28 1.65 2.82 1176.57 1.00 10 25 10 88 TRUE 14.15
pancreatic cancer RAS_12-61 TP53 Any mutation 25 19 Signature 16 2.40 1.78 3.09 1310.15 1.00 6 6 0 19 TRUE 12.93
pancreatic cancer RAS_12-61 TP53 Any mutation 52 41 Signature 17 2.57 1.92 3.23 1169.69 1.00 3 11 0 41 TRUE 14.51
pancreatic cancer RAS_12-61 TP53 Any mutation 15 14 Signature 18 2.31 1.64 2.94 1447.34 1.00 6 3 2 12 TRUE 11.37
pancreatic cancer RAS_12-61 TP53 Any mutation 15 16 Signature 19 2.28 1.68 2.91 1347.40 1.00 8 2 3 13 TRUE 12.44
pancreatic cancer RAS_12-61 TP53 Any mutation 221 172 Signature 1A 2.27 1.77 2.78 1376.32 1.00 22 59 10 162 TRUE 31.05
pancreatic cancer RAS_12-61 TP53 Any mutation 16 12 Signature 1B 2.29 1.60 2.98 1350.47 1.00 4 5 1 11 TRUE 10.83
pancreatic cancer RAS_12-61 TP53 Any mutation 33 29 Signature 2 2.41 1.82 3.07 1246.90 1.00 11 6 2 27 TRUE 13.37
pancreatic cancer RAS_12-61 TP53 Any mutation 26 21 Signature 21 2.40 1.78 3.04 1387.12 1.00 5 6 1 20 TRUE 13.03
pancreatic cancer RAS_12-61 TP53 Any mutation 81 66 Signature 3 2.40 1.86 2.98 1362.23 1.00 13 19 4 62 TRUE 31.05
pancreatic cancer RAS_12-61 TP53 Any mutation 64 58 Signature 4 2.64 2.04 3.33 1290.80 1.00 7 8 2 56 TRUE 14.95
pancreatic cancer RAS_12-61 TP53 Any mutation 61 53 Signature 6 2.42 1.82 3.05 1220.12 1.00 9 12 4 49 TRUE 14.61
pancreatic cancer RAS_12-61 TP53 Any mutation 26 25 Signature 7 2.54 1.92 3.26 1067.42 1.00 8 2 1 24 TRUE 13.12
pancreatic cancer RAS_12-61 TP53 Any mutation 49 37 Signature 8 2.50 1.88 3.17 1241.89 1.00 3 12 0 37 TRUE 14.19
pancreatic cancer RAS_12-61 TP53 Any mutation 23 19 Signature R3 2.47 1.83 3.16 1377.68 1.00 1 5 1 18 TRUE 12.56
pancreatic cancer RAS_12-61 TP53 Any mutation 12 11 Signature U1 2.36 1.68 3.09 1155.62 1.00 10 1 0 11 TRUE 10.97
uterine cancer RAS_12-61 TP53 Any mutation 26 53 Signature 15 -1.64 -2.55 -0.86 1469.82 1.00 34 21 48 5 TRUE 3.93
uterine cancer RAS_12-61 TP53 Any mutation 46 113 Signature 1A -0.93 -1.54 -0.33 1490.60 1.00 88 29 96 17 TRUE 2.61
uterine cancer RAS_12-61 TP53 Any mutation 7 19 Signature 2 -1.90 -3.15 -0.86 1452.56 1.00 22 7 19 0 TRUE 2.91
uterine cancer RAS_12-61 TP53 Any mutation 10 19 Signature 20 -1.35 -2.36 -0.40 1523.35 1.00 18 7 16 3 TRUE 2.16
uterine cancer RAS_12-61 TP53 Any mutation 11 30 Signature 3 -1.39 -2.35 -0.49 1470.97 1.00 10 7 26 4 TRUE 2.50
uterine cancer RAS_12-61 TP53 Any mutation 17 45 Signature 6 -1.91 -2.98 -1.03 1366.59 1.00 46 16 44 1 TRUE 3.77
cancer of unknown primary RAS_12-61 TP53 Any mutation 122 287 Signature overall -0.66 -1.29 -0.03 1420.70 1.00 114 60 225 62 TRUE 1.38
colorectal cancer RAS_12-61 TP53 Any mutation 968 1607 Signature overall -0.90 -1.16 -0.66 1355.23 1.00 242 358 997 610 TRUE 12.07
melanoma RAS_12-61 TP53 Any mutation 184 178 Signature overall 0.04 -0.78 1.08 1230.00 1.00 278 133 127 51 TRUE 0.03
non-small cell lung cancer RAS_12-61 TP53 Any mutation 994 1927 Signature overall -1.23 -1.53 -0.92 1169.64 1.00 648 582 1515 412 TRUE 13.68
pancreatic cancer RAS_12-61 TP53 Any mutation 949 785 Signature overall 2.41 1.99 2.84 1202.91 1.00 131 208 44 741 TRUE 31.05
uterine cancer RAS_12-61 TP53 Any mutation 122 356 Signature overall -1.61 -2.35 -0.97 1526.05 1.00 266 92 326 30 TRUE 5.43
colorectal cancer RAS_12-61 ATRX Any mutation 15 19 Signature 10 -1.17 -2.46 -0.04 1511.49 1.00 14 12 16 3 TRUE 1.23
colorectal cancer RAS_12-61 ATRX Any mutation 371 46 Signature 1A -0.50 -1.10 0.09 1472.35 1.00 450 355 30 16 TRUE 0.97
colorectal cancer RAS_12-61 ATRX Any mutation 123 29 Signature 6 -0.83 -1.68 -0.08 1507.34 1.00 169 116 22 7 TRUE 1.31
melanoma RAS_12-61 ATRX Any mutation 150 76 Signature 7 -0.55 -1.16 0.10 267.98 1.01 260 133 59 17 TRUE 1.09
non-small cell lung cancer RAS_12-61 ATRX Any mutation 69 12 Signature 18 0.00 -0.72 0.81 1509.54 1.00 76 63 6 6 TRUE 0.00
non-small cell lung cancer RAS_12-61 ATRX Any mutation 86 28 Signature 2 -0.01 -0.64 0.65 1615.85 1.00 221 78 20 8 TRUE 0.01
non-small cell lung cancer RAS_12-61 ATRX Any mutation 279 88 Signature 4 -0.06 -0.49 0.38 1460.47 1.00 383 247 56 32 TRUE 0.11
uterine cancer RAS_12-61 ATRX Any mutation 6 11 Signature 14 -0.66 -2.38 1.10 1403.24 1.00 10 4 9 2 TRUE 0.33
uterine cancer RAS_12-61 ATRX Any mutation 44 12 Signature 1A -0.60 -2.32 0.77 1367.31 1.00 165 42 10 2 TRUE 0.35
uterine cancer RAS_12-61 ATRX Any mutation 17 13 Signature 6 -2.36 -5.89 -0.12 1584.35 1.00 71 17 13 0 TRUE 0.98
colorectal cancer RAS_12-61 ATRX Any mutation 509 94 Signature overall -0.81 -2.22 0.54 1471.67 1.00 633 483 68 26 TRUE 0.65
melanoma RAS_12-61 ATRX Any mutation 150 76 Signature overall -0.44 -4.33 3.83 1371.28 1.00 260 133 59 17 TRUE 0.09
non-small cell lung cancer RAS_12-61 ATRX Any mutation 434 128 Signature overall -0.03 -0.67 0.63 1672.01 1.00 680 388 82 46 TRUE 0.03
uterine cancer RAS_12-61 ATRX Any mutation 71 123 Signature overall -0.86 -2.99 1.19 1438.37 1.00 261 63 115 8 TRUE 0.38
colorectal cancer RAS_12-61 ATR Any mutation 15 28 Signature 10 -1.31 -2.64 -0.12 1435.26 1.00 13 11 24 4 FALSE 1.40
colorectal cancer RAS_12-61 ATR Any mutation 174 12 Signature 15 -0.15 -1.22 0.92 1464.79 1.00 208 168 6 6 FALSE 0.11
colorectal cancer RAS_12-61 ATR Any mutation 369 32 Signature 1A -0.49 -1.20 0.18 1472.05 1.00 456 358 21 11 FALSE 0.75
colorectal cancer RAS_12-61 ATR Any mutation 125 28 Signature 6 -0.92 -1.84 -0.06 1467.04 1.00 173 119 22 6 FALSE 1.41
non-small cell lung cancer RAS_12-61 ATR Any mutation 15 11 Signature 13 -0.22 -1.38 1.00 1494.83 1.00 74 13 9 2 FALSE 0.15
non-small cell lung cancer RAS_12-61 ATR Any mutation 86 16 Signature 2 -0.29 -1.24 0.62 1390.65 1.00 226 82 12 4 FALSE 0.27
non-small cell lung cancer RAS_12-61 ATR Any mutation 276 60 Signature 4 -0.48 -1.06 0.07 1474.26 1.00 385 259 43 17 FALSE 1.01
colorectal cancer RAS_12-61 ATR Any mutation 683 100 Signature overall -0.72 -2.06 0.69 1426.34 1.00 850 656 73 27 FALSE 0.54
non-small cell lung cancer RAS_12-61 ATR Any mutation 377 87 Signature overall -0.30 -1.22 0.69 1375.44 1.00 685 354 64 23 FALSE 0.27
non-small cell lung cancer RAS_12-61 PDGFRA Any mutation 86 20 Signature 2 -0.04 -0.93 0.84 1532.22 1.00 224 80 14 6 TRUE 0.04
non-small cell lung cancer RAS_12-61 PDGFRA Any mutation 277 70 Signature 4 -0.25 -0.76 0.24 1375.22 1.00 384 254 47 23 TRUE 0.48
non-small cell lung cancer RAS_12-61 PDGFRA Any mutation 363 90 Signature overall -0.14 -1.33 1.13 1411.23 1.00 608 334 61 29 TRUE 0.09
colorectal cancer RAS_12-61 FBXW7 Any mutation 13 17 Signature 10 -0.25 -1.62 0.69 1449.15 1.00 10 10 14 3 TRUE 0.18
colorectal cancer RAS_12-61 FBXW7 Any mutation 176 48 Signature 15 0.16 -0.37 0.63 1450.23 1.00 192 152 24 24 TRUE 0.27
colorectal cancer RAS_12-61 FBXW7 Any mutation 382 144 Signature 1A 0.40 0.07 0.75 1442.95 1.00 417 305 67 77 TRUE 1.66
colorectal cancer RAS_12-61 FBXW7 Any mutation 128 78 Signature 6 0.52 0.05 1.01 1287.01 1.00 153 88 38 40 TRUE 1.51
uterine cancer RAS_12-61 FBXW7 Any mutation 6 31 Signature 10 0.86 -0.34 2.40 1390.42 1.00 18 0 25 6 TRUE 0.61
uterine cancer RAS_12-61 FBXW7 Any mutation 26 17 Signature 15 -0.23 -1.42 0.79 1470.67 1.00 69 23 14 3 TRUE 0.17
uterine cancer RAS_12-61 FBXW7 Any mutation 44 35 Signature 1A -0.14 -1.03 0.72 1544.08 1.00 147 38 29 6 TRUE 0.13
uterine cancer RAS_12-61 FBXW7 Any mutation 17 18 Signature 6 0.50 -0.58 1.52 1449.88 1.00 67 12 13 5 TRUE 0.45
colorectal cancer RAS_12-61 FBXW7 Any mutation 699 287 Signature overall 0.21 -0.58 0.86 1323.12 1.00 772 555 143 144 TRUE 0.24
uterine cancer RAS_12-61 FBXW7 Any mutation 93 101 Signature overall 0.24 -0.85 1.38 1482.55 1.00 301 73 81 20 TRUE 0.17
uterine cancer RAS_12-61 NSD1 Any mutation 46 22 Signature 1A 0.36 -0.64 1.31 1481.18 1.00 161 40 16 6 FALSE 0.33
uterine cancer RAS_12-61 NSD1 Any mutation 20 29 Signature 6 0.73 -0.31 1.65 1416.10 1.00 66 12 21 8 FALSE 0.82
uterine cancer RAS_12-61 NSD1 Any mutation 70 88 Signature overall 0.73 -0.96 2.64 1603.13 1.00 244 52 70 18 FALSE 0.36
colorectal cancer RAS_12-61 FLT4 Any mutation 13 14 Signature 10 -1.44 -3.14 -0.07 1627.19 1.00 15 12 13 1 TRUE 1.24
colorectal cancer RAS_12-61 FLT4 Any mutation 174 14 Signature 15 -0.43 -1.39 0.44 1594.53 1.00 204 168 8 6 TRUE 0.43
colorectal cancer RAS_12-61 FLT4 Any mutation 371 54 Signature 1A -0.08 -0.65 0.46 1346.98 1.00 448 347 30 24 TRUE 0.11
colorectal cancer RAS_12-61 FLT4 Any mutation 123 51 Signature 6 -1.03 -1.77 -0.40 1394.30 1.00 153 113 41 10 TRUE 2.50
non-small cell lung cancer RAS_12-61 FLT4 Any mutation 86 11 Signature 2 -0.95 -2.61 0.20 1454.89 1.00 228 85 10 1 TRUE 0.76
non-small cell lung cancer RAS_12-61 FLT4 Any mutation 275 36 Signature 4 -0.48 -1.20 0.22 1463.66 1.00 404 264 25 11 TRUE 0.72
colorectal cancer RAS_12-61 FLT4 Any mutation 681 133 Signature overall -0.74 -1.88 0.34 1502.12 1.00 820 640 92 41 TRUE 0.76
non-small cell lung cancer RAS_12-61 FLT4 Any mutation 361 47 Signature overall -0.72 -2.30 0.65 1590.53 1.00 632 349 35 12 TRUE 0.46
colorectal cancer RAS_12-61 PTPRD Any mutation 14 19 Signature 10 -0.94 -2.12 0.18 1567.13 1.00 15 11 16 3 FALSE 0.89
colorectal cancer RAS_12-61 PTPRD Any mutation 173 14 Signature 15 -0.35 -1.31 0.64 1576.16 1.00 206 167 8 6 FALSE 0.32
colorectal cancer RAS_12-61 PTPRD Any mutation 368 31 Signature 1A -0.57 -1.29 0.16 1621.41 1.00 459 358 21 10 FALSE 0.93
colorectal cancer RAS_12-61 PTPRD Any mutation 123 31 Signature 6 -0.69 -1.47 0.06 1406.42 1.00 170 115 23 8 FALSE 1.12
melanoma RAS_12-61 PTPRD Any mutation 160 247 Signature 7 -0.64 -1.02 -0.25 1275.95 1.00 186 104 191 56 FALSE 3.07
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 71 22 Signature 18 0.80 0.03 1.63 1330.51 1.00 75 56 7 15 FALSE 1.29
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 48 12 Signature 1A 0.17 -0.92 1.26 1508.93 1.00 209 45 9 3 FALSE 0.12
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 86 33 Signature 2 0.29 -0.44 0.95 1520.47 1.00 217 75 22 11 FALSE 0.39
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 16 12 Signature 20 -0.10 -1.35 0.93 1531.29 1.00 53 14 10 2 FALSE 0.07
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 56 18 Signature 3 0.72 -0.13 1.54 1507.59 1.00 177 48 10 8 FALSE 1.02
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 293 195 Signature 4 -0.01 -0.35 0.31 1413.37 1.00 334 218 120 75 FALSE 0.02
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 157 18 Signature R2 -0.50 -1.38 0.35 1442.03 1.00 36 146 7 11 FALSE 0.59
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 12 11 Signature U2 0.14 -1.10 1.20 1528.07 1.00 26 9 8 3 FALSE 0.09
colorectal cancer RAS_12-61 PTPRD Any mutation 678 95 Signature overall -0.64 -1.70 0.52 1584.83 1.00 850 651 68 27 FALSE 0.59
melanoma RAS_12-61 PTPRD Any mutation 160 247 Signature overall -0.54 -4.43 3.70 1453.07 1.00 186 104 191 56 FALSE 0.11
non-small cell lung cancer RAS_12-61 PTPRD Any mutation 739 321 Signature overall 0.20 -0.50 0.87 1533.34 1.00 1127 611 193 128 FALSE 0.25
melanoma RAS_12-61 PIK3C2G Any mutation 153 174 Signature 7 -0.46 -0.87 -0.05 888.73 1.00 195 108 129 45 FALSE 1.63
non-small cell lung cancer RAS_12-61 PIK3C2G Any mutation 86 17 Signature 2 -0.69 -1.79 0.25 1462.34 1.00 223 83 14 3 FALSE 0.72
non-small cell lung cancer RAS_12-61 PIK3C2G Any mutation 275 57 Signature 4 -0.70 -1.33 -0.10 1527.80 1.00 388 261 43 14 FALSE 1.59
melanoma RAS_12-61 PIK3C2G Any mutation 153 174 Signature overall -0.38 -4.56 4.07 1445.06 1.00 195 108 129 45 FALSE 0.08
non-small cell lung cancer RAS_12-61 PIK3C2G Any mutation 361 74 Signature overall -0.70 -2.04 0.62 1542.08 1.00 611 344 57 17 FALSE 0.56
colorectal cancer RAS_12-61 CREBBP Any mutation 13 15 Signature 10 -1.10 -2.50 0.10 1568.17 1.00 15 11 13 2 TRUE 1.02
colorectal cancer RAS_12-61 CREBBP Any mutation 173 27 Signature 15 -0.91 -1.70 -0.13 1437.02 1.00 197 166 20 7 TRUE 1.65
colorectal cancer RAS_12-61 CREBBP Any mutation 372 45 Signature 1A 0.11 -0.48 0.70 1476.13 1.00 456 349 22 23 TRUE 0.15
colorectal cancer RAS_12-61 CREBBP Any mutation 132 80 Signature 6 -1.05 -1.67 -0.52 1432.08 1.00 140 115 63 17 TRUE 3.62
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 48 12 Signature 1A 0.06 -0.81 0.92 1266.65 1.00 209 45 9 3 TRUE 0.05
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 86 15 Signature 2 -0.23 -1.10 0.59 1486.63 1.00 225 84 13 2 TRUE 0.23
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 56 11 Signature 3 0.15 -0.67 1.01 1369.28 1.00 180 52 7 4 TRUE 0.14
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 275 44 Signature 4 0.04 -0.54 0.60 1588.29 1.00 405 258 27 17 TRUE 0.05
colorectal cancer RAS_12-61 CREBBP Any mutation 690 167 Signature overall -0.71 -1.77 0.33 1551.45 1.00 808 641 118 49 TRUE 0.73
non-small cell lung cancer RAS_12-61 CREBBP Any mutation 465 82 Signature overall 0.00 -0.70 0.69 1393.68 1.00 1019 439 56 26 TRUE 0.00
colorectal cancer RAS_12-61 AXIN2 Any mutation 173 17 Signature 15 -0.63 -1.47 0.26 1566.46 1.00 203 167 11 6 TRUE 0.82
colorectal cancer RAS_12-61 AXIN2 Any mutation 368 36 Signature 1A -0.41 -1.03 0.24 1495.17 1.00 459 354 22 14 TRUE 0.67
colorectal cancer RAS_12-61 AXIN2 Any mutation 124 40 Signature 6 -1.09 -1.94 -0.34 1379.62 1.00 163 118 34 6 TRUE 2.14
colorectal cancer RAS_12-61 AXIN2 Any mutation 665 93 Signature overall -0.71 -1.63 0.17 1574.81 1.00 825 639 67 26 TRUE 0.95
non-small cell lung cancer RAS_12-61 DOT1L Any mutation 86 16 Signature 2 -0.39 -1.44 0.48 1424.48 1.00 225 83 13 3 FALSE 0.37
non-small cell lung cancer RAS_12-61 DOT1L Any mutation 275 38 Signature 4 -0.17 -0.79 0.46 1318.64 1.00 404 261 24 14 FALSE 0.24
non-small cell lung cancer RAS_12-61 DOT1L Any mutation 361 54 Signature overall -0.29 -1.53 0.90 1249.92 1.00 629 344 37 17 FALSE 0.21
colorectal cancer RAS_12-61 PTPRS Any mutation 14 16 Signature 10 -1.05 -2.26 0.03 1412.59 1.00 12 12 14 2 FALSE 1.10
colorectal cancer RAS_12-61 PTPRS Any mutation 171 38 Signature 15 -0.30 -0.90 0.32 1496.45 1.00 189 155 22 16 FALSE 0.46
colorectal cancer RAS_12-61 PTPRS Any mutation 360 95 Signature 1A -0.10 -0.52 0.33 1485.71 1.00 420 319 54 41 FALSE 0.20
colorectal cancer RAS_12-61 PTPRS Any mutation 123 83 Signature 6 -0.91 -1.48 -0.37 1398.33 1.00 140 105 65 18 FALSE 2.86
colorectal cancer RAS_12-61 PTPRS Any mutation 668 232 Signature overall -0.60 -1.48 0.20 1431.63 1.00 761 591 155 77 FALSE 0.77
colorectal cancer RAS_12-61 SMARCA4 Any mutation 174 22 Signature 15 -0.45 -1.13 0.28 1545.38 1.00 204 165 13 9 FALSE 0.70
colorectal cancer RAS_12-61 SMARCA4 Any mutation 373 74 Signature 1A -0.41 -0.88 0.05 1387.82 1.00 439 346 47 27 FALSE 1.07
colorectal cancer RAS_12-61 SMARCA4 Any mutation 124 52 Signature 6 -1.04 -1.80 -0.40 1644.52 1.00 158 116 44 8 FALSE 2.45
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 15 11 Signature 13 0.40 -0.70 1.51 1360.44 1.00 75 12 8 3 FALSE 0.33
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 69 14 Signature 18 0.72 -0.15 1.69 1390.77 1.00 78 59 4 10 FALSE 0.90
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 48 17 Signature 1A 0.19 -0.76 1.11 1485.30 1.00 207 44 13 4 FALSE 0.16
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 88 33 Signature 2 -0.08 -0.88 0.63 1504.16 1.00 218 80 25 8 FALSE 0.08
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 56 16 Signature 3 0.63 -0.33 1.48 1631.15 1.00 179 49 9 7 FALSE 0.77
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 276 104 Signature 4 -0.34 -0.77 0.08 1487.00 1.00 361 244 72 32 FALSE 0.91
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 25 15 Signature 7 0.18 -0.73 1.10 1479.21 1.00 72 21 11 4 FALSE 0.15
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 156 15 Signature R2 -0.25 -1.12 0.66 1451.47 1.00 37 146 5 10 FALSE 0.23
uterine cancer RAS_12-61 SMARCA4 Any mutation 28 14 Signature 15 0.13 -0.84 1.10 1337.89 1.00 76 23 9 5 FALSE 0.10
uterine cancer RAS_12-61 SMARCA4 Any mutation 44 21 Signature 1A -0.36 -1.36 0.58 1379.42 1.00 159 41 18 3 FALSE 0.34
uterine cancer RAS_12-61 SMARCA4 Any mutation 19 30 Signature 6 -0.27 -1.20 0.65 1509.10 1.00 66 15 26 4 FALSE 0.24
colorectal cancer RAS_12-61 SMARCA4 Any mutation 671 148 Signature overall -0.63 -1.46 0.14 1590.23 1.00 801 627 104 44 FALSE 0.91
non-small cell lung cancer RAS_12-61 SMARCA4 Any mutation 733 225 Signature overall 0.17 -0.51 0.83 1529.27 1.00 1227 655 147 78 FALSE 0.22
uterine cancer RAS_12-61 SMARCA4 Any mutation 94 76 Signature overall -0.17 -1.12 0.76 1355.24 1.00 328 81 63 13 FALSE 0.14
colorectal cancer RAS_12-61 PTPRT Any mutation 17 23 Signature 10 -0.88 -1.93 0.22 1299.77 1.00 12 12 18 5 FALSE 0.98
colorectal cancer RAS_12-61 PTPRT Any mutation 173 25 Signature 15 -1.35 -2.32 -0.49 1284.42 1.00 192 169 21 4 FALSE 2.38
colorectal cancer RAS_12-61 PTPRT Any mutation 369 66 Signature 1A 0.03 -0.48 0.50 1526.68 1.00 443 338 35 31 FALSE 0.04
colorectal cancer RAS_12-61 PTPRT Any mutation 125 43 Signature 6 -0.52 -1.19 0.11 1529.93 1.00 159 112 30 13 FALSE 0.91
melanoma RAS_12-61 PTPRT Any mutation 17 12 Signature 11 -0.32 -1.56 0.85 1555.30 1.00 34 14 9 3 FALSE 0.22
melanoma RAS_12-61 PTPRT Any mutation 177 346 Signature 7 -0.12 -0.46 0.23 1455.27 1.00 167 77 246 100 FALSE 0.31
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 15 11 Signature 13 0.27 -1.02 1.59 1488.06 1.00 77 12 8 3 FALSE 0.17
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 68 17 Signature 18 -0.67 -1.63 0.24 1547.91 1.00 71 63 12 5 FALSE 0.77
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 48 11 Signature 1A -1.25 -3.08 0.17 1461.39 1.00 210 48 11 0 FALSE 0.86
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 87 30 Signature 2 0.86 0.16 1.64 1523.88 1.00 224 72 15 15 FALSE 1.66
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 56 19 Signature 3 -0.54 -1.73 0.47 1466.64 1.00 173 53 16 3 FALSE 0.49
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 279 179 Signature 4 -0.86 -1.24 -0.48 1562.07 1.00 328 238 138 41 FALSE 5.19
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 158 23 Signature R2 -0.51 -1.33 0.32 1503.82 1.00 37 143 8 15 FALSE 0.64
colorectal cancer RAS_12-61 PTPRT Any mutation 684 157 Signature overall -0.70 -1.82 0.29 1465.00 1.00 806 631 104 53 FALSE 0.75
melanoma RAS_12-61 PTPRT Any mutation 194 358 Signature overall -0.22 -2.07 1.67 1528.53 1.00 201 91 255 103 FALSE 0.09
non-small cell lung cancer RAS_12-61 PTPRT Any mutation 711 290 Signature overall -0.37 -1.19 0.44 1701.51 1.00 1120 629 208 82 FALSE 0.42
non-small cell lung cancer RAS_12-61 HGF Any mutation 86 20 Signature 2 0.58 -0.35 1.48 1274.64 1.00 227 77 11 9 FALSE 0.66
non-small cell lung cancer RAS_12-61 HGF Any mutation 275 89 Signature 4 -0.31 -0.77 0.17 1348.83 1.00 376 246 60 29 FALSE 0.71
non-small cell lung cancer RAS_12-61 HGF Any mutation 157 12 Signature R2 -1.08 -2.21 0.02 1706.91 1.00 37 151 6 6 FALSE 1.23
non-small cell lung cancer RAS_12-61 HGF Any mutation 518 121 Signature overall -0.28 -1.81 1.20 1434.24 1.00 640 474 77 44 FALSE 0.14
colorectal cancer RAS_12-61 PIK3CA Any mutation 14 23 Signature 10 0.11 -0.85 0.91 1353.05 1.00 12 8 17 6 TRUE 0.10
colorectal cancer RAS_12-61 PIK3CA Any mutation 173 63 Signature 15 0.26 -0.22 0.70 1428.07 1.00 186 141 31 32 TRUE 0.57
colorectal cancer RAS_12-61 PIK3CA Any mutation 20 19 Signature 18 0.22 -0.58 0.92 1313.06 1.00 16 13 12 7 TRUE 0.25
colorectal cancer RAS_12-61 PIK3CA Any mutation 379 191 Signature 1A 0.51 0.21 0.81 1447.17 1.00 398 275 87 104 TRUE 2.89
colorectal cancer RAS_12-61 PIK3CA Any mutation 50 43 Signature 2 1.07 0.45 1.78 1581.69 1.00 24 18 11 32 TRUE 2.86
colorectal cancer RAS_12-61 PIK3CA Any mutation 132 95 Signature 6 0.45 0.00 0.86 1584.72 1.00 145 86 49 46 TRUE 1.40
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 16 13 Signature 13 0.93 -0.17 2.03 1430.91 1.00 76 10 7 6 TRUE 1.01
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 48 13 Signature 1A 0.03 -1.09 1.05 1454.17 1.00 209 45 10 3 TRUE 0.02
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 87 82 Signature 2 0.12 -0.42 0.62 1416.39 1.00 184 64 59 23 TRUE 0.19
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 16 16 Signature 20 -0.08 -1.28 0.96 1606.32 1.00 48 13 13 3 TRUE 0.06
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 56 15 Signature 3 -1.07 -2.54 0.07 1614.74 1.00 172 56 15 0 TRUE 0.96
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 275 38 Signature 4 -0.45 -1.11 0.16 1468.01 1.00 401 264 27 11 TRUE 0.77
uterine cancer RAS_12-61 PIK3CA Any mutation 8 63 Signature 10 0.54 -0.45 1.63 1515.94 1.00 7 0 55 8 TRUE 0.50
uterine cancer RAS_12-61 PIK3CA Any mutation 29 50 Signature 15 0.05 -0.73 0.78 1470.72 1.00 50 18 39 11 TRUE 0.04
uterine cancer RAS_12-61 PIK3CA Any mutation 54 138 Signature 1A 0.98 0.40 1.57 1821.23 1.00 100 14 98 40 TRUE 2.93
uterine cancer RAS_12-61 PIK3CA Any mutation 8 30 Signature 2 0.37 -0.68 1.43 1478.77 1.00 17 3 25 5 TRUE 0.31
uterine cancer RAS_12-61 PIK3CA Any mutation 10 25 Signature 20 0.24 -0.81 1.26 1433.43 1.00 14 5 20 5 TRUE 0.19
uterine cancer RAS_12-61 PIK3CA Any mutation 12 21 Signature 3 1.10 0.11 2.18 1463.07 1.00 23 3 12 9 TRUE 1.46
uterine cancer RAS_12-61 PIK3CA Any mutation 24 85 Signature 6 0.68 -0.10 1.51 1234.80 1.00 34 5 66 19 TRUE 1.00
colorectal cancer RAS_12-61 PIK3CA Any mutation 768 434 Signature overall 0.44 -0.08 0.94 1386.86 1.00 781 541 207 227 TRUE 1.04
non-small cell lung cancer RAS_12-61 PIK3CA Any mutation 498 177 Signature overall -0.08 -0.89 0.68 1557.93 1.00 1090 452 131 46 TRUE 0.07
uterine cancer RAS_12-61 PIK3CA Any mutation 151 459 Signature overall 0.47 -0.16 1.13 1647.06 1.00 306 50 358 101 TRUE 0.82
colorectal cancer RAS_12-61 ALK Any mutation 14 13 Signature 10 -0.47 -1.77 0.58 1467.63 1.00 15 11 10 3 TRUE 0.36
colorectal cancer RAS_12-61 ALK Any mutation 173 16 Signature 15 0.51 -0.33 1.45 1533.29 1.00 207 162 5 11 TRUE 0.57
colorectal cancer RAS_12-61 ALK Any mutation 370 35 Signature 1A -0.24 -0.90 0.39 1537.62 1.00 457 356 21 14 TRUE 0.32
colorectal cancer RAS_12-61 ALK Any mutation 123 37 Signature 6 -0.80 -1.62 -0.07 1393.97 1.00 166 115 29 8 TRUE 1.37
melanoma RAS_12-61 ALK Any mutation 151 117 Signature 7 -0.25 -0.69 0.19 344.75 1.01 237 118 84 33 TRUE 0.53
non-small cell lung cancer RAS_12-61 ALK Any mutation 86 24 Signature 2 0.30 -0.46 1.08 1459.00 1.00 225 77 15 9 TRUE 0.36
non-small cell lung cancer RAS_12-61 ALK Any mutation 275 72 Signature 4 -0.06 -0.56 0.46 1597.67 1.00 386 249 46 26 TRUE 0.08
colorectal cancer RAS_12-61 ALK Any mutation 680 101 Signature overall -0.24 -1.29 0.81 1465.46 1.00 845 644 65 36 TRUE 0.19
melanoma RAS_12-61 ALK Any mutation 151 117 Signature overall -0.23 -4.74 3.67 1600.80 1.00 237 118 84 33 TRUE 0.04
non-small cell lung cancer RAS_12-61 ALK Any mutation 361 96 Signature overall 0.14 -0.95 1.36 1427.95 1.00 611 326 61 35 TRUE 0.09
colorectal cancer RAS_12-61 RNF43 Any mutation 176 31 Signature 15 -0.98 -1.75 -0.27 1458.53 1.00 196 168 23 8 TRUE 2.04
colorectal cancer RAS_12-61 RNF43 Any mutation 376 93 Signature 1A -0.60 -1.04 -0.19 1564.43 1.00 435 346 63 30 TRUE 2.05
colorectal cancer RAS_12-61 RNF43 Any mutation 128 102 Signature 6 -1.13 -1.70 -0.61 1583.18 1.00 130 108 82 20 TRUE 4.58
colorectal cancer RAS_12-61 RNF43 Any mutation 680 226 Signature overall -0.89 -1.82 0.00 1451.68 1.00 761 622 168 58 TRUE 1.28
colorectal cancer RAS_12-61 PTEN Any mutation 14 13 Signature 10 -0.34 -1.48 0.60 1490.77 1.00 14 11 10 3 TRUE 0.27
colorectal cancer RAS_12-61 PTEN Any mutation 173 22 Signature 15 0.22 -0.48 0.97 1409.49 1.00 204 160 9 13 TRUE 0.24
colorectal cancer RAS_12-61 PTEN Any mutation 373 64 Signature 1A -0.16 -0.64 0.34 1353.10 1.00 450 347 38 26 TRUE 0.29
colorectal cancer RAS_12-61 PTEN Any mutation 128 57 Signature 6 -0.30 -0.86 0.28 1713.04 1.00 164 110 39 18 TRUE 0.52
non-small cell lung cancer RAS_12-61 PTEN Any mutation 86 27 Signature 2 -0.85 -1.87 0.03 1338.49 1.00 218 82 23 4 TRUE 1.12
non-small cell lung cancer RAS_12-61 PTEN Any mutation 275 27 Signature 4 -0.90 -1.72 -0.17 1357.84 1.00 407 269 21 6 TRUE 1.59
uterine cancer RAS_12-61 PTEN Any mutation 7 61 Signature 10 0.63 -0.33 1.55 1460.55 1.00 10 0 54 7 TRUE 0.73
uterine cancer RAS_12-61 PTEN Any mutation 8 14 Signature 14 1.06 0.01 2.00 1463.71 1.00 10 2 8 6 TRUE 1.47
uterine cancer RAS_12-61 PTEN Any mutation 37 61 Signature 15 1.11 0.50 1.82 1512.92 1.00 57 12 36 25 TRUE 3.05
uterine cancer RAS_12-61 PTEN Any mutation 63 155 Signature 1A 1.05 0.54 1.59 1543.66 1.00 112 16 108 47 TRUE 4.07
uterine cancer RAS_12-61 PTEN Any mutation 7 15 Signature 1B 1.34 0.41 2.37 1607.69 1.00 8 0 8 7 TRUE 2.11
uterine cancer RAS_12-61 PTEN Any mutation 9 26 Signature 2 0.60 -0.31 1.46 1471.88 1.00 24 4 21 5 TRUE 0.74
uterine cancer RAS_12-61 PTEN Any mutation 14 28 Signature 20 1.28 0.45 2.19 1510.13 1.00 19 2 16 12 TRUE 2.38
uterine cancer RAS_12-61 PTEN Any mutation 14 17 Signature 3 1.21 0.32 2.15 1701.63 1.00 29 5 8 9 TRUE 2.06
uterine cancer RAS_12-61 PTEN Any mutation 25 104 Signature 6 0.32 -0.46 1.09 1549.82 1.00 23 7 86 18 TRUE 0.37
colorectal cancer RAS_12-61 PTEN Any mutation 688 156 Signature overall -0.13 -0.97 0.68 1361.50 1.00 832 628 96 60 TRUE 0.12
non-small cell lung cancer RAS_12-61 PTEN Any mutation 361 54 Signature overall -0.84 -2.15 0.43 1378.75 1.00 625 351 44 10 TRUE 0.68
uterine cancer RAS_12-61 PTEN Any mutation 197 545 Signature overall 0.81 0.31 1.35 1560.11 1.00 335 54 402 143 TRUE 2.63
colorectal cancer RAS_12-61 BCOR Any mutation 13 11 Signature 10 -0.72 -2.15 0.57 1621.58 1.00 15 11 9 2 FALSE 0.52
colorectal cancer RAS_12-61 BCOR Any mutation 173 13 Signature 15 -0.42 -1.43 0.56 1492.07 1.00 205 168 8 5 FALSE 0.39
colorectal cancer RAS_12-61 BCOR Any mutation 368 27 Signature 1A 0.38 -0.35 1.11 1702.05 1.00 466 352 11 16 FALSE 0.52
colorectal cancer RAS_12-61 BCOR Any mutation 129 49 Signature 6 -0.52 -1.21 0.12 1455.11 1.00 161 115 35 14 FALSE 0.94
non-small cell lung cancer RAS_12-61 BCOR Any mutation 87 13 Signature 2 0.22 -0.76 1.11 1621.64 1.00 229 83 9 4 FALSE 0.20
non-small cell lung cancer RAS_12-61 BCOR Any mutation 279 52 Signature 4 0.46 -0.06 0.97 1388.21 1.00 404 253 26 26 FALSE 1.04
uterine cancer RAS_12-61 BCOR Any mutation 44 30 Signature 1A 0.24 -0.69 1.06 1398.75 1.00 154 37 23 7 FALSE 0.23
uterine cancer RAS_12-61 BCOR Any mutation 19 23 Signature 6 1.01 -0.04 1.99 1564.03 1.00 69 11 15 8 FALSE 1.26
colorectal cancer RAS_12-61 BCOR Any mutation 683 100 Signature overall -0.32 -1.49 0.82 1595.79 1.00 847 646 63 37 FALSE 0.24
non-small cell lung cancer RAS_12-61 BCOR Any mutation 366 65 Signature overall 0.32 -0.94 1.40 1503.30 1.00 633 336 35 30 FALSE 0.22
uterine cancer RAS_12-61 BCOR Any mutation 66 83 Signature overall 0.45 -1.16 1.96 1710.22 1.00 244 49 66 17 FALSE 0.23
colorectal cancer RAS_12-61 CTNNB1 Any mutation 173 22 Signature 15 0.51 -0.03 0.87 13.15 1.09 202 162 11 11 TRUE 1.54
colorectal cancer RAS_12-61 CTNNB1 Any mutation 371 61 Signature 1A 0.64 0.27 1.05 1109.97 1.00 455 332 22 39 TRUE 3.35
colorectal cancer RAS_12-61 CTNNB1 Any mutation 124 33 Signature 6 0.55 0.06 0.95 506.87 1.01 172 109 18 15 TRUE 1.97
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 48 11 Signature 1A -1.50 -3.04 -0.16 1408.10 1.00 208 47 10 1 TRUE 1.42
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 86 14 Signature 2 -1.64 -3.06 -0.42 1424.51 1.00 225 85 13 1 TRUE 1.83
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 56 17 Signature 3 -1.18 -2.53 0.01 1560.67 1.00 173 53 14 3 TRUE 1.15
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 275 16 Signature 4 -2.05 -3.61 -0.82 1156.79 1.00 411 275 16 0 TRUE 2.27
uterine cancer RAS_12-61 CTNNB1 Any mutation 26 11 Signature 15 -1.38 -2.75 -0.19 1424.40 1.00 74 25 10 1 TRUE 1.43
uterine cancer RAS_12-61 CTNNB1 Any mutation 44 31 Signature 1A -1.43 -2.68 -0.32 1213.07 1.00 147 42 29 2 TRUE 1.80
uterine cancer RAS_12-61 CTNNB1 Any mutation 17 19 Signature 6 -1.44 -2.88 -0.26 1350.36 1.00 64 16 18 1 TRUE 1.54
colorectal cancer RAS_12-61 CTNNB1 Any mutation 668 116 Signature overall 0.57 0.12 0.93 501.98 1.02 829 603 51 65 TRUE 2.28
non-small cell lung cancer RAS_12-61 CTNNB1 Any mutation 465 58 Signature overall -1.57 -2.84 -0.50 1199.50 1.00 1017 460 53 5 TRUE 2.08
uterine cancer RAS_12-61 CTNNB1 Any mutation 91 83 Signature overall -1.39 -2.63 -0.31 1393.76 1.00 351 86 78 5 TRUE 1.76
cancer of unknown primary RAS_12-61 ARID1A Any mutation 40 22 Signature 1A -0.51 -1.36 0.32 1127.88 1.00 66 34 16 6 TRUE 0.63
cancer of unknown primary RAS_12-61 ARID1A Any mutation 9 13 Signature 2 -0.56 -1.61 0.50 1344.58 1.00 36 7 11 2 TRUE 0.55
cancer of unknown primary RAS_12-61 ARID1A Any mutation 23 12 Signature 4 -0.55 -1.51 0.40 1381.69 1.00 49 20 9 3 TRUE 0.60
cancer of unknown primary RAS_12-61 ARID1A Any mutation 6 11 Signature 6 -0.82 -2.22 0.17 1192.83 1.00 15 6 11 0 TRUE 0.71
colorectal cancer RAS_12-61 ARID1A Any mutation 14 13 Signature 10 -0.68 -1.62 0.18 1346.21 1.00 15 11 10 3 TRUE 0.85
colorectal cancer RAS_12-61 ARID1A Any mutation 175 39 Signature 15 -0.87 -1.51 -0.28 1347.18 1.00 197 165 29 10 TRUE 2.24
colorectal cancer RAS_12-61 ARID1A Any mutation 381 130 Signature 1A -0.40 -0.77 -0.02 1673.86 1.00 420 333 82 48 TRUE 1.43
colorectal cancer RAS_12-61 ARID1A Any mutation 130 99 Signature 6 -0.74 -1.21 -0.27 1321.17 1.00 138 105 74 25 TRUE 2.62
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 15 17 Signature 13 -1.24 -3.00 0.16 1388.61 1.00 68 15 17 0 TRUE 0.90
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 71 12 Signature 18 0.70 -0.31 1.85 1370.07 1.00 79 62 3 9 TRUE 0.72
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 90 52 Signature 2 0.52 -0.05 1.11 1579.78 1.00 211 70 32 20 TRUE 1.10
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 56 11 Signature 3 -0.42 -1.68 0.78 1399.64 1.00 178 54 9 2 TRUE 0.30
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 276 86 Signature 4 -0.74 -1.25 -0.28 1552.62 1.00 364 255 65 21 TRUE 2.47
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 156 13 Signature R2 -0.43 -1.44 0.59 1406.50 1.00 38 147 4 9 TRUE 0.39
pancreatic cancer RAS_12-61 ARID1A Any mutation 118 12 Signature 11 0.14 -1.21 2.53 1139.65 1.00 8 106 0 12 TRUE 0.05
pancreatic cancer RAS_12-61 ARID1A Any mutation 223 33 Signature 1A -0.25 -1.20 0.83 1447.17 1.00 27 196 6 27 TRUE 0.20
uterine cancer RAS_12-61 ARID1A Any mutation 7 21 Signature 14 0.95 -0.13 1.97 1528.46 1.00 9 2 16 5 TRUE 1.13
uterine cancer RAS_12-61 ARID1A Any mutation 32 58 Signature 15 1.14 0.44 1.84 1421.57 1.00 59 11 37 21 TRUE 2.84
uterine cancer RAS_12-61 ARID1A Any mutation 60 133 Signature 1A 1.24 0.68 1.85 1479.85 1.00 114 16 89 44 TRUE 4.55
uterine cancer RAS_12-61 ARID1A Any mutation 10 23 Signature 2 1.34 0.32 2.39 1426.90 1.00 27 2 15 8 TRUE 2.07
uterine cancer RAS_12-61 ARID1A Any mutation 13 26 Signature 20 1.66 0.69 2.73 1188.99 1.00 20 1 14 12 TRUE 2.83
uterine cancer RAS_12-61 ARID1A Any mutation 24 121 Signature 6 0.70 -0.20 1.56 1508.28 1.00 26 4 101 20 TRUE 0.93
cancer of unknown primary RAS_12-61 ARID1A Any mutation 78 58 Signature overall -0.61 -1.53 0.26 1305.05 1.00 166 67 47 11 TRUE 0.76
colorectal cancer RAS_12-61 ARID1A Any mutation 700 281 Signature overall -0.67 -1.34 -0.10 1420.13 1.00 770 614 195 86 TRUE 1.50
non-small cell lung cancer RAS_12-61 ARID1A Any mutation 664 191 Signature overall -0.26 -1.22 0.64 1493.68 1.00 938 603 130 61 TRUE 0.24
pancreatic cancer RAS_12-61 ARID1A Any mutation 341 45 Signature overall -0.07 -1.55 1.93 1375.98 1.00 35 302 6 39 TRUE 0.03
uterine cancer RAS_12-61 ARID1A Any mutation 152 445 Signature overall 1.04 0.37 1.70 1480.95 1.00 273 37 330 115 TRUE 2.66
colorectal cancer RAS_12-61 PIK3R1 Any mutation 15 17 Signature 10 -0.51 -1.71 0.56 1254.09 1.00 13 11 13 4 TRUE 0.43
colorectal cancer RAS_12-61 PIK3R1 Any mutation 173 17 Signature 15 0.11 -0.70 0.99 1598.52 1.00 207 164 8 9 TRUE 0.10
colorectal cancer RAS_12-61 PIK3R1 Any mutation 369 31 Signature 1A -0.15 -0.86 0.51 1553.21 1.00 461 356 18 13 TRUE 0.18
colorectal cancer RAS_12-61 PIK3R1 Any mutation 124 31 Signature 6 -0.18 -0.92 0.55 1640.29 1.00 171 113 20 11 TRUE 0.20
uterine cancer RAS_12-61 PIK3R1 Any mutation 29 32 Signature 15 0.47 -0.33 1.32 1414.74 1.00 68 15 18 14 TRUE 0.55
uterine cancer RAS_12-61 PIK3R1 Any mutation 46 59 Signature 1A -0.50 -1.24 0.19 1403.52 1.00 129 39 52 7 TRUE 0.77
uterine cancer RAS_12-61 PIK3R1 Any mutation 11 13 Signature 20 0.12 -0.76 1.12 1385.25 1.00 24 6 8 5 TRUE 0.10
uterine cancer RAS_12-61 PIK3R1 Any mutation 18 31 Signature 6 -0.60 -1.62 0.18 1490.46 1.00 58 16 29 2 TRUE 0.69
colorectal cancer RAS_12-61 PIK3R1 Any mutation 681 96 Signature overall -0.22 -1.32 0.87 1575.26 1.00 852 644 59 37 TRUE 0.17
uterine cancer RAS_12-61 PIK3R1 Any mutation 112 167 Signature overall -0.21 -0.88 0.44 1516.73 1.00 315 82 137 30 TRUE 0.27
melanoma RAS_12-61 IKZF1 Any mutation 154 93 Signature 7 -0.06 -0.52 0.40 1456.18 1.00 250 124 63 30 TRUE 0.10
melanoma RAS_12-61 IKZF1 Any mutation 154 93 Signature overall -0.11 -4.46 4.08 1391.76 1.00 250 124 63 30 TRUE 0.02
colorectal cancer RAS_12-61 FAT1 Any mutation 22 44 Signature 10 -0.85 -1.81 0.06 1412.87 1.00 12 11 33 11 FALSE 1.12
colorectal cancer RAS_12-61 FAT1 Any mutation 173 29 Signature 15 -1.85 -3.03 -0.88 1276.40 1.00 195 170 26 3 FALSE 3.21
colorectal cancer RAS_12-61 FAT1 Any mutation 373 66 Signature 1A -0.40 -0.91 0.09 1623.70 1.00 443 349 42 24 FALSE 0.91
colorectal cancer RAS_12-61 FAT1 Any mutation 127 67 Signature 6 -0.71 -1.30 -0.15 1550.01 1.00 152 109 49 18 FALSE 1.87
melanoma RAS_12-61 FAT1 Any mutation 153 128 Signature 7 -0.01 -0.46 0.43 605.26 1.01 237 112 87 41 FALSE 0.02
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 15 16 Signature 13 0.04 -0.94 0.95 1480.90 1.00 71 13 14 2 FALSE 0.03
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 68 16 Signature 18 0.58 -0.20 1.38 1532.97 1.00 76 58 6 10 FALSE 0.80
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 48 13 Signature 1A 0.39 -0.55 1.35 1395.19 1.00 212 44 9 4 FALSE 0.39
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 88 38 Signature 2 0.18 -0.47 0.81 1515.78 1.00 215 77 27 11 FALSE 0.24
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 17 11 Signature 20 0.73 -0.28 1.71 1481.72 1.00 55 12 6 5 FALSE 0.84
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 56 13 Signature 3 0.58 -0.28 1.45 1493.14 1.00 180 50 7 6 FALSE 0.71
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 277 121 Signature 4 -0.38 -0.80 0.03 1444.84 1.00 353 242 86 35 FALSE 1.20
uterine cancer RAS_12-61 FAT1 Any mutation 26 14 Signature 15 -0.24 -1.54 0.94 1537.96 1.00 75 23 11 3 FALSE 0.15
uterine cancer RAS_12-61 FAT1 Any mutation 44 24 Signature 1A -0.64 -1.90 0.49 1361.06 1.00 158 41 21 3 FALSE 0.53
uterine cancer RAS_12-61 FAT1 Any mutation 17 37 Signature 6 0.01 -1.05 1.00 1547.98 1.00 62 11 31 6 FALSE 0.01
colorectal cancer RAS_12-61 FAT1 Any mutation 695 206 Signature overall -0.93 -2.02 0.25 1451.09 1.00 802 639 150 56 FALSE 0.95
melanoma RAS_12-61 FAT1 Any mutation 153 128 Signature overall -0.04 -3.99 4.12 1500.46 1.00 237 112 87 41 FALSE 0.01
non-small cell lung cancer RAS_12-61 FAT1 Any mutation 569 228 Signature overall 0.30 -0.29 0.91 1412.36 1.00 1162 496 155 73 FALSE 0.50
uterine cancer RAS_12-61 FAT1 Any mutation 92 149 Signature overall -0.17 -1.74 1.49 1525.69 1.00 307 75 132 17 FALSE 0.08
colorectal cancer RAS_12-61 CIC Any mutation 174 19 Signature 15 -0.84 -1.61 -0.10 1442.08 1.00 204 169 14 5 TRUE 1.53
colorectal cancer RAS_12-61 CIC Any mutation 371 58 Signature 1A -0.37 -0.91 0.14 1362.62 1.00 449 348 35 23 TRUE 0.77
colorectal cancer RAS_12-61 CIC Any mutation 124 43 Signature 6 -1.00 -1.75 -0.33 1425.59 1.00 162 117 36 7 TRUE 2.14
colorectal cancer RAS_12-61 CIC Any mutation 669 120 Signature overall -0.73 -1.51 -0.02 1522.85 1.00 815 634 85 35 TRUE 1.21
colorectal cancer RAS_12-61 NCOR1 Any mutation 13 16 Signature 10 -1.04 -2.33 0.06 1477.82 1.00 13 11 14 2 FALSE 1.07
colorectal cancer RAS_12-61 NCOR1 Any mutation 173 22 Signature 15 -0.41 -1.18 0.40 1214.62 1.00 202 164 13 9 FALSE 0.50
colorectal cancer RAS_12-61 NCOR1 Any mutation 371 44 Signature 1A -0.70 -1.34 -0.12 1519.14 1.00 450 358 31 13 FALSE 1.63
colorectal cancer RAS_12-61 NCOR1 Any mutation 125 43 Signature 6 -0.61 -1.25 0.04 1464.51 1.00 165 113 31 12 FALSE 1.17
non-small cell lung cancer RAS_12-61 NCOR1 Any mutation 16 14 Signature 13 0.36 -0.82 1.68 1635.15 1.00 76 12 10 4 FALSE 0.24
non-small cell lung cancer RAS_12-61 NCOR1 Any mutation 86 11 Signature 2 -0.22 -1.39 0.89 1474.02 1.00 233 83 8 3 FALSE 0.15
non-small cell lung cancer RAS_12-61 NCOR1 Any mutation 276 36 Signature 4 -1.03 -1.89 -0.27 1469.74 1.00 398 270 30 6 FALSE 1.85
colorectal cancer RAS_12-61 NCOR1 Any mutation 682 125 Signature overall -0.68 -1.68 0.21 1334.64 1.00 830 646 89 36 FALSE 0.85
non-small cell lung cancer RAS_12-61 NCOR1 Any mutation 378 61 Signature overall -0.28 -1.57 0.95 1499.28 1.00 707 365 48 13 FALSE 0.18
colorectal cancer RAS_12-61 POLE Any mutation 14 20 Signature 10 -0.82 -2.04 0.32 1526.70 1.00 12 10 16 4 TRUE 0.74
colorectal cancer RAS_12-61 POLE Any mutation 173 19 Signature 15 -0.89 -1.81 -0.07 1457.56 1.00 202 168 14 5 TRUE 1.31
colorectal cancer RAS_12-61 POLE Any mutation 371 36 Signature 1A -0.02 -0.66 0.63 1296.19 1.00 460 354 19 17 TRUE 0.02
colorectal cancer RAS_12-61 POLE Any mutation 126 54 Signature 6 -0.72 -1.40 -0.04 1384.70 1.00 155 112 40 14 TRUE 1.54
non-small cell lung cancer RAS_12-61 POLE Any mutation 87 19 Signature 2 0.32 -0.69 1.23 1502.42 1.00 227 80 12 7 TRUE 0.29
non-small cell lung cancer RAS_12-61 POLE Any mutation 275 49 Signature 4 -0.35 -0.98 0.24 1617.37 1.00 396 260 34 15 TRUE 0.60
non-small cell lung cancer RAS_12-61 POLE Any mutation 156 11 Signature R2 0.12 -1.06 1.37 1395.44 1.00 40 147 2 9 TRUE 0.07
uterine cancer RAS_12-61 POLE Any mutation 6 57 Signature 10 1.35 -0.73 4.58 1307.34 1.00 11 0 51 6 TRUE 0.50
uterine cancer RAS_12-61 POLE Any mutation 44 12 Signature 1A 0.58 -0.65 1.72 1567.02 1.00 168 40 8 4 TRUE 0.47
uterine cancer RAS_12-61 POLE Any mutation 18 20 Signature 6 0.55 -0.62 1.73 1460.96 1.00 71 13 15 5 TRUE 0.45
colorectal cancer RAS_12-61 POLE Any mutation 684 129 Signature overall -0.62 -1.74 0.42 1534.16 1.00 829 644 89 40 TRUE 0.59
non-small cell lung cancer RAS_12-61 POLE Any mutation 518 79 Signature overall 0.03 -1.37 1.40 1455.33 1.00 663 487 48 31 TRUE 0.01
uterine cancer RAS_12-61 POLE Any mutation 68 89 Signature overall 0.81 -1.59 3.22 1527.79 1.00 250 53 74 15 TRUE 0.30
non-small cell lung cancer RAS_12-61 NOTCH2 Any mutation 86 15 Signature 2 -0.93 -2.21 0.10 1501.13 1.00 223 84 13 2 TRUE 0.96
non-small cell lung cancer RAS_12-61 NOTCH2 Any mutation 275 54 Signature 4 -0.75 -1.40 -0.17 1245.07 1.00 396 262 41 13 TRUE 1.77
non-small cell lung cancer RAS_12-61 NOTCH2 Any mutation 361 69 Signature overall -0.84 -2.14 0.44 1510.94 1.00 619 346 54 15 TRUE 0.77
colorectal cancer RAS_12-61 TGFBR2 Any mutation 174 11 Signature 15 -0.48 -1.40 0.41 1462.07 1.00 205 170 7 4 TRUE 0.52
colorectal cancer RAS_12-61 TGFBR2 Any mutation 369 48 Signature 1A -0.11 -0.67 0.46 1437.03 1.00 453 348 27 21 TRUE 0.15
colorectal cancer RAS_12-61 TGFBR2 Any mutation 123 43 Signature 6 -0.48 -1.14 0.13 1492.05 1.00 159 111 31 12 TRUE 0.84
colorectal cancer RAS_12-61 TGFBR2 Any mutation 666 102 Signature overall -0.34 -1.29 0.55 1419.87 1.00 817 629 65 37 TRUE 0.34
colorectal cancer RAS_12-61 KMT2A Any mutation 17 22 Signature 10 -0.50 -1.54 0.46 1556.11 1.00 16 11 16 6 FALSE 0.49
colorectal cancer RAS_12-61 KMT2A Any mutation 174 19 Signature 15 -1.37 -2.45 -0.43 1202.47 1.00 198 171 16 3 FALSE 2.10
colorectal cancer RAS_12-61 KMT2A Any mutation 370 53 Signature 1A 0.02 -0.53 0.56 1541.33 1.00 452 345 28 25 FALSE 0.02
colorectal cancer RAS_12-61 KMT2A Any mutation 124 42 Signature 6 -1.05 -1.84 -0.35 1261.37 1.00 163 116 34 8 FALSE 2.23
melanoma RAS_12-61 KMT2A Any mutation 151 124 Signature 7 -0.58 -1.05 -0.14 1332.02 1.00 237 123 96 28 FALSE 1.89
non-small cell lung cancer RAS_12-61 KMT2A Any mutation 86 23 Signature 2 -0.13 -0.97 0.62 1517.23 1.00 223 80 17 6 FALSE 0.12
non-small cell lung cancer RAS_12-61 KMT2A Any mutation 275 37 Signature 4 -0.19 -0.85 0.47 1380.38 1.00 404 262 24 13 FALSE 0.24
uterine cancer RAS_12-61 KMT2A Any mutation 44 13 Signature 1A 0.79 -0.47 1.96 1485.79 1.00 167 39 8 5 FALSE 0.70
uterine cancer RAS_12-61 KMT2A Any mutation 17 14 Signature 6 -0.97 -3.16 0.65 1526.80 1.00 68 16 13 1 FALSE 0.49
colorectal cancer RAS_12-61 KMT2A Any mutation 685 136 Signature overall -0.73 -1.78 0.26 1433.51 1.00 829 643 94 42 FALSE 0.81
melanoma RAS_12-61 KMT2A Any mutation 151 124 Signature overall -0.53 -4.16 3.72 1513.31 1.00 237 123 96 28 FALSE 0.11
non-small cell lung cancer RAS_12-61 KMT2A Any mutation 361 60 Signature overall -0.17 -1.26 0.84 1387.57 1.00 627 342 41 19 FALSE 0.12
uterine cancer RAS_12-61 KMT2A Any mutation 66 81 Signature overall 0.36 -2.18 3.18 1525.01 1.00 253 55 70 11 FALSE 0.11
melanoma RAS_12-61 PAK7 Any mutation 150 205 Signature 7 -0.71 -1.09 -0.32 1138.79 1.01 168 102 157 48 FALSE 3.36
non-small cell lung cancer RAS_12-61 PAK7 Any mutation 275 69 Signature 4 -0.35 -0.88 0.17 1070.76 1.00 387 253 47 22 FALSE 0.71
melanoma RAS_12-61 PAK7 Any mutation 150 205 Signature overall -0.57 -4.58 3.67 1401.88 1.00 168 102 157 48 FALSE 0.12
non-small cell lung cancer RAS_12-61 PAK7 Any mutation 275 69 Signature overall -0.32 -4.73 3.95 1363.06 1.00 387 253 47 22 FALSE 0.06
non-small cell lung cancer RAS_12-61 STAG2 Any mutation 86 16 Signature 2 0.04 -0.92 0.86 1403.08 1.00 227 82 12 4 TRUE 0.03
non-small cell lung cancer RAS_12-61 STAG2 Any mutation 276 43 Signature 4 0.28 -0.31 0.87 1499.57 1.00 407 256 23 20 TRUE 0.47
non-small cell lung cancer RAS_12-61 STAG2 Any mutation 362 59 Signature overall 0.15 -0.97 1.24 1330.23 1.00 634 338 35 24 TRUE 0.10
melanoma RAS_12-61 TERT Any mutation 18 48 Signature 11 1.13 -0.04 2.42 1544.55 1.00 11 2 32 16 TRUE 1.16
melanoma RAS_12-61 TERT Any mutation 11 20 Signature 19 1.55 0.17 3.05 1349.08 1.00 6 1 10 10 TRUE 1.53
melanoma RAS_12-61 TERT Any mutation 13 17 Signature 1A 1.25 0.20 2.44 1577.90 1.00 41 6 10 7 TRUE 1.56
melanoma RAS_12-61 TERT Any mutation 175 473 Signature 7 0.89 0.32 1.45 1289.46 1.00 59 14 312 161 TRUE 2.57
non-small cell lung cancer RAS_12-61 TERT Any mutation 87 23 Signature 2 0.86 0.04 1.70 305.32 1.02 227 75 11 12 TRUE 1.32
non-small cell lung cancer RAS_12-61 TERT Any mutation 276 54 Signature 4 0.11 -0.48 0.67 1504.62 1.00 398 255 33 21 TRUE 0.16
melanoma RAS_12-61 TERT Any mutation 217 558 Signature overall 1.18 -0.01 2.37 1509.71 1.00 117 23 364 194 TRUE 1.27
non-small cell lung cancer RAS_12-61 TERT Any mutation 363 77 Signature overall 0.49 -0.75 1.89 1494.05 1.00 625 330 44 33 TRUE 0.35
colorectal cancer RAS_12-61 BRCA2 Any mutation 16 37 Signature 10 -1.72 -2.88 -0.58 1431.08 1.00 13 12 33 4 TRUE 2.41
colorectal cancer RAS_12-61 BRCA2 Any mutation 173 17 Signature 15 -1.10 -2.18 -0.12 1586.96 1.00 204 169 13 4 TRUE 1.46
colorectal cancer RAS_12-61 BRCA2 Any mutation 373 50 Signature 1A 0.08 -0.48 0.66 1629.49 1.00 455 349 26 24 TRUE 0.11
colorectal cancer RAS_12-61 BRCA2 Any mutation 127 62 Signature 6 -1.04 -1.69 -0.41 1390.45 1.00 154 114 49 13 TRUE 2.74
non-small cell lung cancer RAS_12-61 BRCA2 Any mutation 15 13 Signature 13 -1.35 -3.56 0.01 1500.79 1.00 72 15 13 0 TRUE 0.82
non-small cell lung cancer RAS_12-61 BRCA2 Any mutation 86 15 Signature 2 -1.02 -2.38 0.06 1449.36 1.00 226 84 13 2 TRUE 0.97
non-small cell lung cancer RAS_12-61 BRCA2 Any mutation 276 55 Signature 4 -0.49 -1.05 0.06 1526.88 1.00 395 259 38 17 TRUE 1.03
uterine cancer RAS_12-61 BRCA2 Any mutation 44 15 Signature 1A 0.57 -0.60 1.66 1553.58 1.00 165 39 10 5 TRUE 0.50
uterine cancer RAS_12-61 BRCA2 Any mutation 17 22 Signature 6 -1.43 -3.57 0.09 1574.77 1.00 66 16 21 1 TRUE 0.89
colorectal cancer RAS_12-61 BRCA2 Any mutation 689 166 Signature overall -0.93 -2.21 0.42 1524.74 1.00 826 644 121 45 TRUE 0.82
non-small cell lung cancer RAS_12-61 BRCA2 Any mutation 377 83 Signature overall -0.92 -2.33 0.22 1219.63 1.00 693 358 64 19 TRUE 0.81
uterine cancer RAS_12-61 BRCA2 Any mutation 66 102 Signature overall 0.08 -2.52 2.68 1509.80 1.00 246 55 91 11 TRUE 0.02
colorectal cancer RAS_12-61 NOTCH3 Any mutation 173 27 Signature 15 -0.43 -1.13 0.26 1515.45 1.00 201 162 16 11 TRUE 0.62
colorectal cancer RAS_12-61 NOTCH3 Any mutation 369 70 Signature 1A -0.67 -1.21 -0.18 1339.21 1.00 439 348 49 21 TRUE 1.98
colorectal cancer RAS_12-61 NOTCH3 Any mutation 125 72 Signature 6 -0.99 -1.59 -0.44 1623.38 1.00 148 111 58 14 TRUE 3.09
melanoma RAS_12-61 NOTCH3 Any mutation 149 116 Signature 7 -1.01 -1.57 -0.50 1283.56 1.00 229 129 96 20 TRUE 3.65
non-small cell lung cancer RAS_12-61 NOTCH3 Any mutation 68 11 Signature 18 0.28 -0.57 1.24 1661.16 1.00 79 61 4 7 TRUE 0.27
non-small cell lung cancer RAS_12-61 NOTCH3 Any mutation 86 15 Signature 2 -0.06 -0.88 0.77 1588.20 1.00 228 82 11 4 TRUE 0.06
non-small cell lung cancer RAS_12-61 NOTCH3 Any mutation 275 48 Signature 4 -0.19 -0.77 0.37 1556.68 1.00 399 260 33 15 TRUE 0.30
colorectal cancer RAS_12-61 NOTCH3 Any mutation 667 169 Signature overall -0.69 -1.48 0.20 1620.53 1.00 788 621 123 46 TRUE 0.94
melanoma RAS_12-61 NOTCH3 Any mutation 149 116 Signature overall -0.89 -4.87 3.51 1577.77 1.00 229 129 96 20 TRUE 0.19
non-small cell lung cancer RAS_12-61 NOTCH3 Any mutation 429 74 Signature overall 0.01 -0.73 0.76 1515.55 1.00 706 403 48 26 TRUE 0.01
colorectal cancer RAS_12-61 NOTCH4 Any mutation 169 18 Signature 15 -0.90 -1.79 -0.19 1409.85 1.00 196 165 14 4 TRUE 1.61
colorectal cancer RAS_12-61 NOTCH4 Any mutation 357 43 Signature 1A -0.62 -1.19 -0.06 1534.38 1.00 440 343 29 14 TRUE 1.53
colorectal cancer RAS_12-61 NOTCH4 Any mutation 121 41 Signature 6 -0.61 -1.24 0.01 1458.40 1.00 158 110 30 11 TRUE 1.25
melanoma RAS_12-61 NOTCH4 Any mutation 148 141 Signature 7 -0.19 -0.63 0.22 1290.16 1.00 207 106 99 42 TRUE 0.43
non-small cell lung cancer RAS_12-61 NOTCH4 Any mutation 275 74 Signature 4 -0.48 -1.01 0.01 1126.78 1.00 381 253 52 22 TRUE 1.24
colorectal cancer RAS_12-61 NOTCH4 Any mutation 647 102 Signature overall -0.71 -1.53 -0.02 1415.90 1.00 794 618 73 29 TRUE 1.22
melanoma RAS_12-61 NOTCH4 Any mutation 148 141 Signature overall -0.11 -3.98 4.14 1492.59 1.00 207 106 99 42 TRUE 0.02
non-small cell lung cancer RAS_12-61 NOTCH4 Any mutation 275 74 Signature overall -0.46 -4.55 3.52 1553.25 1.00 381 253 52 22 TRUE 0.09
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 15 20 Signature 13 -0.08 -1.08 0.81 1533.62 1.00 65 13 18 2 FALSE 0.06
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 21 12 Signature 14 0.18 -0.73 1.05 1625.07 1.00 27 17 8 4 FALSE 0.15
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 32 16 Signature 15 0.67 -0.13 1.48 1456.23 1.00 96 25 9 7 FALSE 1.01
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 10 12 Signature 16 0.18 -0.81 1.14 1535.40 1.00 40 8 10 2 FALSE 0.14
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 69 34 Signature 18 0.37 -0.25 1.03 1513.70 1.00 66 52 17 17 FALSE 0.58
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 17 11 Signature 19 0.81 -0.13 1.70 1469.38 1.00 41 11 5 6 FALSE 1.10
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 48 27 Signature 1A 0.52 -0.22 1.28 1549.05 1.00 201 40 19 8 FALSE 0.79
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 86 55 Signature 2 0.03 -0.55 0.58 1541.04 1.00 200 72 41 14 FALSE 0.04
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 16 13 Signature 20 0.61 -0.33 1.54 1652.03 1.00 53 11 8 5 FALSE 0.72
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 56 31 Signature 3 0.54 -0.13 1.21 1338.19 1.00 167 45 20 11 FALSE 0.96
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 279 175 Signature 4 -0.06 -0.40 0.30 1431.24 1.00 320 214 110 65 FALSE 0.13
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 25 14 Signature 7 0.09 -0.79 0.94 1414.18 1.00 73 22 11 3 FALSE 0.07
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 157 45 Signature R2 0.20 -0.41 0.80 1599.95 1.00 32 123 11 34 FALSE 0.27
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 23 11 Signature U1 1.03 0.16 1.97 1391.66 1.00 84 16 4 7 FALSE 1.61
non-small cell lung cancer RAS_12-61 KEAP1 Any mutation 854 476 Signature overall 0.37 -0.04 0.80 1405.03 1.00 1465 669 291 185 FALSE 1.05
non-small cell lung cancer RAS_12-61 KDM5C Any mutation 86 15 Signature 2 -0.40 -1.86 0.64 1463.67 1.00 226 84 13 2 FALSE 0.26
non-small cell lung cancer RAS_12-61 KDM5C Any mutation 276 41 Signature 4 0.50 -0.09 1.14 1121.91 1.00 409 254 19 22 FALSE 0.97
non-small cell lung cancer RAS_12-61 KDM5C Any mutation 362 56 Signature overall 0.07 -1.58 1.53 1495.52 1.00 635 338 32 24 FALSE 0.03
melanoma RAS_12-61 CDKN2A Any mutation 152 108 Signature 7 -0.27 -0.73 0.18 1094.78 1.00 229 121 77 31 TRUE 0.60
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 15 12 Signature 13 -1.15 -2.91 0.25 1565.53 1.00 71 15 12 0 TRUE 0.82
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 32 11 Signature 15 -0.91 -2.46 0.38 1350.52 1.00 94 31 10 1 TRUE 0.68
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 48 18 Signature 1A 0.62 -0.37 1.57 1400.94 1.00 207 41 11 7 TRUE 0.69
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 86 22 Signature 2 -1.40 -2.78 -0.30 1585.86 1.00 218 85 21 1 TRUE 1.54
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 57 20 Signature 3 0.07 -0.85 0.93 1465.99 1.00 173 51 14 6 TRUE 0.06
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 278 90 Signature 4 -0.62 -1.12 -0.15 1133.66 1.00 366 254 66 24 TRUE 1.93
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 156 11 Signature R2 -0.16 -1.20 0.96 1301.26 1.00 40 147 2 9 TRUE 0.11
pancreatic cancer RAS_12-61 CDKN2A Any mutation 119 30 Signature 11 1.53 0.79 2.30 1365.92 1.00 7 90 1 29 TRUE 4.85
pancreatic cancer RAS_12-61 CDKN2A Any mutation 114 27 Signature 15 1.37 0.51 2.07 48.01 1.04 15 92 5 22 TRUE 3.49
pancreatic cancer RAS_12-61 CDKN2A Any mutation 51 11 Signature 17 1.54 0.72 2.38 1346.27 1.01 3 40 0 11 TRUE 4.35
pancreatic cancer RAS_12-61 CDKN2A Any mutation 225 67 Signature 1A 1.61 0.92 2.36 1465.02 1.00 29 160 2 65 TRUE 6.03
pancreatic cancer RAS_12-61 CDKN2A Any mutation 85 23 Signature 3 1.57 0.87 2.41 1328.95 1.00 17 62 0 23 TRUE 4.93
pancreatic cancer RAS_12-61 CDKN2A Any mutation 65 25 Signature 4 1.71 0.98 2.59 1290.02 1.00 9 40 0 25 TRUE 5.38
pancreatic cancer RAS_12-61 CDKN2A Any mutation 61 26 Signature 6 1.70 1.02 2.63 106.00 1.03 13 35 0 26 TRUE 5.09
pancreatic cancer RAS_12-61 CDKN2A Any mutation 49 11 Signature 8 1.55 0.76 2.33 1313.10 1.01 3 38 0 11 TRUE 4.52
melanoma RAS_12-61 CDKN2A Any mutation 152 108 Signature overall -0.28 -4.50 3.57 1506.01 1.00 229 121 77 31 TRUE 0.05
non-small cell lung cancer RAS_12-61 CDKN2A Any mutation 672 184 Signature overall -0.50 -1.38 0.28 1605.19 1.00 1169 624 136 48 TRUE 0.62
pancreatic cancer RAS_12-61 CDKN2A Any mutation 769 220 Signature overall 1.58 0.90 2.32 1309.33 1.00 96 557 8 212 TRUE 5.76
non-small cell lung cancer RAS_12-61 EPHB1 Any mutation 86 17 Signature 2 -0.48 -1.48 0.53 1248.85 1.00 226 82 13 4 FALSE 0.45
non-small cell lung cancer RAS_12-61 EPHB1 Any mutation 277 79 Signature 4 -0.75 -1.30 -0.23 1477.38 1.00 377 258 60 19 FALSE 2.28
non-small cell lung cancer RAS_12-61 EPHB1 Any mutation 363 96 Signature overall -0.62 -2.30 1.06 1344.51 1.00 603 340 73 23 FALSE 0.37
uterine cancer RAS_12-61 PPP2R1A Any mutation 26 20 Signature 15 -1.02 -2.22 0.02 1468.64 1.00 66 24 18 2 FALSE 1.15
uterine cancer RAS_12-61 PPP2R1A Any mutation 44 25 Signature 1A -0.84 -2.02 0.17 1530.67 1.00 155 41 22 3 FALSE 0.90
uterine cancer RAS_12-61 PPP2R1A Any mutation 11 14 Signature 3 -0.83 -2.18 0.28 1576.61 1.00 22 9 12 2 FALSE 0.77
uterine cancer RAS_12-61 PPP2R1A Any mutation 17 17 Signature 6 -0.55 -1.71 0.57 1552.57 1.00 71 14 14 3 FALSE 0.45
uterine cancer RAS_12-61 PPP2R1A Any mutation 99 96 Signature overall -0.88 -1.93 0.07 1655.55 1.00 346 89 86 10 FALSE 1.07
colorectal cancer RAS_12-61 ERBB3 Any mutation 173 18 Signature 15 -0.06 -0.74 0.60 1482.16 1.00 201 166 11 7 TRUE 0.07
colorectal cancer RAS_12-61 ERBB3 Any mutation 370 46 Signature 1A 0.02 -0.49 0.52 1322.72 1.00 457 350 26 20 TRUE 0.03
colorectal cancer RAS_12-61 ERBB3 Any mutation 124 34 Signature 6 0.32 -0.26 0.93 1430.03 1.00 175 107 17 17 TRUE 0.53
colorectal cancer RAS_12-61 ERBB3 Any mutation 667 98 Signature overall 0.10 -0.51 0.73 1318.60 1.00 833 623 54 44 TRUE 0.13
colorectal cancer RAS_12-61 SMAD4 Any mutation 14 17 Signature 10 0.25 -0.33 0.81 1448.24 1.00 14 8 11 6 TRUE 0.41
colorectal cancer RAS_12-61 SMAD4 Any mutation 175 60 Signature 15 0.16 -0.22 0.58 1400.09 1.00 185 145 30 30 TRUE 0.36
colorectal cancer RAS_12-61 SMAD4 Any mutation 16 11 Signature 17 0.18 -0.40 0.75 1622.79 1.00 23 12 7 4 TRUE 0.27
colorectal cancer RAS_12-61 SMAD4 Any mutation 22 12 Signature 19 0.29 -0.22 0.86 1422.28 1.00 19 15 5 7 TRUE 0.54
colorectal cancer RAS_12-61 SMAD4 Any mutation 375 122 Signature 1A 0.11 -0.19 0.41 1552.66 1.00 415 318 65 57 TRUE 0.32
colorectal cancer RAS_12-61 SMAD4 Any mutation 46 11 Signature 2 0.16 -0.41 0.68 1447.07 1.00 32 39 4 7 TRUE 0.24
colorectal cancer RAS_12-61 SMAD4 Any mutation 125 57 Signature 6 0.07 -0.38 0.47 1384.80 1.00 159 103 35 22 TRUE 0.14
colorectal cancer RAS_12-61 SMAD4 Any mutation 16 11 Signature 7 0.29 -0.24 0.91 1340.35 1.00 19 10 5 6 TRUE 0.50
non-small cell lung cancer RAS_12-61 SMAD4 Any mutation 48 17 Signature 1A -0.18 -1.38 0.84 1558.45 1.00 205 46 15 2 TRUE 0.13
non-small cell lung cancer RAS_12-61 SMAD4 Any mutation 86 21 Signature 2 0.71 -0.14 1.56 1529.10 1.00 227 76 11 10 TRUE 1.01
non-small cell lung cancer RAS_12-61 SMAD4 Any mutation 275 16 Signature 4 -0.08 -1.03 0.74 1653.44 1.00 417 269 10 6 TRUE 0.06
pancreatic cancer RAS_12-61 SMAD4 Any mutation 117 25 Signature 11 0.41 -0.17 0.98 973.16 1.00 7 93 1 24 TRUE 0.77
pancreatic cancer RAS_12-61 SMAD4 Any mutation 113 31 Signature 15 0.44 -0.13 1.03 857.36 1.00 17 85 3 28 TRUE 0.86
pancreatic cancer RAS_12-61 SMAD4 Any mutation 52 12 Signature 17 0.43 -0.16 1.07 1024.19 1.00 3 40 0 12 TRUE 0.81
pancreatic cancer RAS_12-61 SMAD4 Any mutation 222 56 Signature 1A 0.46 -0.08 1.04 993.58 1.00 28 169 3 53 TRUE 0.95
pancreatic cancer RAS_12-61 SMAD4 Any mutation 33 12 Signature 2 0.35 -0.31 0.95 930.29 1.00 8 26 5 7 TRUE 0.56
pancreatic cancer RAS_12-61 SMAD4 Any mutation 82 24 Signature 3 0.44 -0.12 1.02 973.12 1.00 14 61 3 21 TRUE 0.86
pancreatic cancer RAS_12-61 SMAD4 Any mutation 64 15 Signature 4 0.41 -0.20 1.01 954.73 1.00 8 50 1 14 TRUE 0.74
pancreatic cancer RAS_12-61 SMAD4 Any mutation 61 15 Signature 6 0.35 -0.27 0.97 811.26 1.00 9 50 4 11 TRUE 0.57
pancreatic cancer RAS_12-61 SMAD4 Any mutation 50 15 Signature 8 0.49 -0.10 1.11 1136.17 1.00 3 35 0 15 TRUE 0.97
colorectal cancer RAS_12-61 SMAD4 Any mutation 789 301 Signature overall 0.19 -0.18 0.54 1421.09 1.00 866 650 162 139 TRUE 0.54
non-small cell lung cancer RAS_12-61 SMAD4 Any mutation 409 54 Signature overall 0.16 -0.91 1.20 1602.91 1.00 849 391 36 18 TRUE 0.11
pancreatic cancer RAS_12-61 SMAD4 Any mutation 794 205 Signature overall 0.42 -0.10 0.96 914.26 1.00 97 609 20 185 TRUE 0.93
colorectal cancer RAS_12-61 ATM Any mutation 20 39 Signature 10 -0.61 -1.62 0.31 1386.99 1.00 12 10 29 10 TRUE 0.68
colorectal cancer RAS_12-61 ATM Any mutation 175 32 Signature 15 -0.15 -0.84 0.55 1407.87 1.00 197 161 18 14 TRUE 0.17
colorectal cancer RAS_12-61 ATM Any mutation 372 77 Signature 1A 0.19 -0.25 0.65 1420.90 1.00 444 334 39 38 TRUE 0.39
colorectal cancer RAS_12-61 ATM Any mutation 124 48 Signature 6 -1.08 -1.85 -0.36 1408.46 1.00 157 115 39 9 TRUE 2.31
non-small cell lung cancer RAS_12-61 ATM Any mutation 15 12 Signature 13 0.96 -0.12 2.03 1383.49 1.00 75 11 8 4 TRUE 1.14
non-small cell lung cancer RAS_12-61 ATM Any mutation 68 11 Signature 18 0.53 -0.44 1.44 1510.50 1.00 78 62 5 6 TRUE 0.57
non-small cell lung cancer RAS_12-61 ATM Any mutation 88 27 Signature 2 0.83 0.11 1.54 1124.85 1.00 224 76 15 12 TRUE 1.63
non-small cell lung cancer RAS_12-61 ATM Any mutation 56 13 Signature 3 0.72 -0.24 1.60 1313.69 1.00 179 51 8 5 TRUE 0.90
non-small cell lung cancer RAS_12-61 ATM Any mutation 287 95 Signature 4 0.77 0.36 1.19 1555.39 1.00 390 234 42 53 TRUE 3.54
non-small cell lung cancer RAS_12-61 ATM Any mutation 157 25 Signature R2 0.68 -0.18 1.58 1466.30 1.00 38 136 4 21 TRUE 0.89
non-small cell lung cancer RAS_12-61 ATM Any mutation 14 12 Signature U2 1.65 0.58 2.71 1542.91 1.00 29 6 4 8 TRUE 2.62
uterine cancer RAS_12-61 ATM Any mutation 6 11 Signature 14 -0.40 -2.04 1.25 1357.48 1.00 10 4 9 2 TRUE 0.20
uterine cancer RAS_12-61 ATM Any mutation 44 23 Signature 1A -0.29 -1.42 0.76 1546.39 1.00 160 40 19 4 TRUE 0.23
uterine cancer RAS_12-61 ATM Any mutation 18 24 Signature 6 -0.49 -1.79 0.68 1536.81 1.00 67 15 21 3 TRUE 0.35
colorectal cancer RAS_12-61 ATM Any mutation 691 196 Signature overall -0.41 -1.55 0.72 1450.26 1.00 810 620 125 71 TRUE 0.33
non-small cell lung cancer RAS_12-61 ATM Any mutation 685 195 Signature overall 0.87 0.13 1.57 1475.80 1.00 1013 576 86 109 TRUE 1.84
uterine cancer RAS_12-61 ATM Any mutation 73 121 Signature overall -0.24 -1.73 1.31 1536.68 1.00 250 59 107 14 TRUE 0.12
non-small cell lung cancer RAS_12-61 RB1 Any mutation 15 11 Signature 13 -0.41 -1.36 0.66 1590.99 1.00 77 12 8 3 TRUE 0.36
non-small cell lung cancer RAS_12-61 RB1 Any mutation 68 11 Signature 18 -0.63 -1.51 0.22 1512.33 1.00 75 64 7 4 TRUE 0.84
non-small cell lung cancer RAS_12-61 RB1 Any mutation 48 16 Signature 1A -0.75 -1.68 0.14 1388.19 1.00 204 46 14 2 TRUE 0.96
non-small cell lung cancer RAS_12-61 RB1 Any mutation 86 28 Signature 2 -0.82 -1.63 -0.09 1272.99 1.00 214 82 24 4 TRUE 1.37
non-small cell lung cancer RAS_12-61 RB1 Any mutation 56 18 Signature 3 -1.21 -2.27 -0.27 1493.42 1.00 169 56 18 0 TRUE 1.65
non-small cell lung cancer RAS_12-61 RB1 Any mutation 275 67 Signature 4 -0.83 -1.37 -0.35 1310.38 1.00 379 260 52 15 TRUE 2.74
non-small cell lung cancer RAS_12-61 RB1 Any mutation 548 151 Signature overall -0.78 -1.45 -0.15 1497.67 1.00 1118 520 123 28 TRUE 1.70
cancer of unknown primary RAS_12-61 KMT2D Any mutation 38 18 Signature 1A -1.43 -2.68 -0.34 1464.09 1.00 65 35 15 3 FALSE 1.77
cancer of unknown primary RAS_12-61 KMT2D Any mutation 23 15 Signature 4 -1.50 -2.84 -0.23 1598.75 1.00 46 21 13 2 FALSE 1.58
cancer of unknown primary RAS_12-61 KMT2D Any mutation 6 13 Signature 6 -2.00 -3.93 -0.49 1532.30 1.00 13 6 13 0 FALSE 1.68
colorectal cancer RAS_12-61 KMT2D Any mutation 14 19 Signature 10 -1.09 -2.17 -0.17 1533.82 1.00 12 11 16 3 FALSE 1.45
colorectal cancer RAS_12-61 KMT2D Any mutation 174 55 Signature 15 -1.20 -1.86 -0.57 1502.53 1.00 190 163 44 11 FALSE 3.73
colorectal cancer RAS_12-61 KMT2D Any mutation 380 128 Signature 1A -0.53 -0.92 -0.16 1346.63 1.00 427 337 85 43 FALSE 2.23
colorectal cancer RAS_12-61 KMT2D Any mutation 139 142 Signature 6 -0.89 -1.32 -0.47 1516.69 1.00 127 104 107 35 FALSE 4.30
melanoma RAS_12-61 KMT2D Any mutation 16 13 Signature 11 -0.25 -0.99 0.76 247.60 1.01 30 12 9 4 FALSE 0.26
melanoma RAS_12-61 KMT2D Any mutation 166 184 Signature 7 -0.30 -0.65 0.11 76.53 1.03 223 115 133 51 FALSE 0.85
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 15 16 Signature 13 -1.30 -2.99 0.01 1389.94 1.00 68 15 16 0 FALSE 1.11
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 68 16 Signature 18 -0.85 -1.83 0.09 1452.12 1.00 72 64 12 4 FALSE 1.05
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 50 22 Signature 1A -0.10 -1.12 0.81 1526.95 1.00 202 45 17 5 FALSE 0.08
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 87 46 Signature 2 -0.26 -0.95 0.41 1481.63 1.00 209 76 35 11 FALSE 0.34
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 56 13 Signature 3 -1.03 -2.43 0.08 1336.20 1.00 175 55 12 1 FALSE 0.99
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 278 129 Signature 4 -0.74 -1.16 -0.33 1377.30 1.00 350 246 97 32 FALSE 3.37
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 156 13 Signature R2 -0.16 -1.12 0.90 1444.14 1.00 40 145 2 11 FALSE 0.12
uterine cancer RAS_12-61 KMT2D Any mutation 8 24 Signature 14 0.04 -0.96 1.09 1416.86 1.00 9 3 19 5 FALSE 0.03
uterine cancer RAS_12-61 KMT2D Any mutation 27 27 Signature 15 0.17 -0.66 0.98 1315.74 1.00 68 19 19 8 FALSE 0.16
uterine cancer RAS_12-61 KMT2D Any mutation 45 61 Signature 1A -0.25 -0.98 0.42 1478.15 1.00 135 35 51 10 FALSE 0.32
uterine cancer RAS_12-61 KMT2D Any mutation 10 13 Signature 20 0.18 -0.80 1.35 1464.11 1.00 24 6 9 4 FALSE 0.13
uterine cancer RAS_12-61 KMT2D Any mutation 19 63 Signature 6 -0.18 -1.00 0.57 1164.93 1.00 44 10 54 9 FALSE 0.18
cancer of unknown primary RAS_12-61 KMT2D Any mutation 72 76 Signature overall -1.65 -2.88 -0.50 1472.84 1.00 153 66 70 6 FALSE 2.13
colorectal cancer RAS_12-61 KMT2D Any mutation 707 344 Signature overall -0.93 -1.69 -0.21 1582.53 1.00 756 615 252 92 FALSE 1.88
melanoma RAS_12-61 KMT2D Any mutation 182 197 Signature overall -0.28 -1.17 0.78 650.84 1.00 253 127 142 55 FALSE 0.24
non-small cell lung cancer RAS_12-61 KMT2D Any mutation 710 255 Signature overall -0.63 -1.41 0.16 1335.57 1.00 1116 646 191 64 FALSE 0.96
uterine cancer RAS_12-61 KMT2D Any mutation 114 233 Signature overall -0.02 -0.78 0.75 1408.23 1.00 299 74 193 40 FALSE 0.02
colorectal cancer RAS_12-61 TSC2 Any mutation 173 11 Signature 15 -0.08 -1.12 1.00 1418.04 1.00 207 167 5 6 TRUE 0.06
colorectal cancer RAS_12-61 TSC2 Any mutation 371 36 Signature 1A -0.18 -0.80 0.45 1325.31 1.00 460 356 21 15 TRUE 0.24
colorectal cancer RAS_12-61 TSC2 Any mutation 123 44 Signature 6 -0.84 -1.59 -0.15 1546.31 1.00 162 114 35 9 TRUE 1.58
colorectal cancer RAS_12-61 TSC2 Any mutation 667 91 Signature overall -0.39 -1.48 0.74 1568.07 1.00 829 637 61 30 TRUE 0.32
colorectal cancer RAS_12-61 APC Any mutation 32 94 Signature 10 0.27 -0.24 0.80 1479.69 1.00 3 0 62 32 TRUE 0.52
colorectal cancer RAS_12-61 APC Any mutation 31 39 Signature 11 0.29 -0.26 0.81 1322.13 1.00 1 9 17 22 TRUE 0.54
colorectal cancer RAS_12-61 APC Any mutation 18 25 Signature 14 0.60 0.08 1.19 1350.25 1.00 2 1 8 17 TRUE 1.47
colorectal cancer RAS_12-61 APC Any mutation 266 469 Signature 15 0.54 0.17 0.90 1368.19 1.00 55 28 231 238 TRUE 2.51
colorectal cancer RAS_12-61 APC Any mutation 23 46 Signature 17 0.24 -0.32 0.78 1523.60 1.00 11 4 27 19 TRUE 0.43
colorectal cancer RAS_12-61 APC Any mutation 28 63 Signature 18 0.15 -0.39 0.66 1312.22 1.00 3 5 40 23 TRUE 0.25
colorectal cancer RAS_12-61 APC Any mutation 27 38 Signature 19 0.13 -0.46 0.66 1451.55 1.00 8 10 21 17 TRUE 0.20
colorectal cancer RAS_12-61 APC Any mutation 537 962 Signature 1A 0.23 -0.03 0.50 1482.35 1.00 129 92 517 445 TRUE 1.05
colorectal cancer RAS_12-61 APC Any mutation 14 22 Signature 1B 0.43 -0.13 1.01 1551.68 1.00 7 1 9 13 TRUE 0.87
colorectal cancer RAS_12-61 APC Any mutation 66 95 Signature 2 0.49 0.02 0.99 1358.58 1.00 8 9 38 57 TRUE 1.34
colorectal cancer RAS_12-61 APC Any mutation 20 34 Signature 20 0.29 -0.24 0.83 1523.40 1.00 4 4 18 16 TRUE 0.54
colorectal cancer RAS_12-61 APC Any mutation 13 25 Signature 21 0.41 -0.12 1.03 1475.88 1.00 10 0 12 13 TRUE 0.82
colorectal cancer RAS_12-61 APC Any mutation 25 42 Signature 3 0.42 -0.14 0.97 1375.52 1.00 8 3 20 22 TRUE 0.89
colorectal cancer RAS_12-61 APC Any mutation 29 49 Signature 4 0.26 -0.28 0.76 1486.11 1.00 5 6 26 23 TRUE 0.49
colorectal cancer RAS_12-61 APC Any mutation 184 355 Signature 6 0.26 -0.08 0.60 1532.31 1.00 62 33 204 151 TRUE 0.89
colorectal cancer RAS_12-61 APC Any mutation 23 40 Signature 7 0.38 -0.14 0.98 1464.45 1.00 9 3 20 20 TRUE 0.76
colorectal cancer RAS_12-61 APC Any mutation 21 30 Signature 8 0.55 0.00 1.15 1419.88 1.00 1 2 11 19 TRUE 1.31
colorectal cancer RAS_12-61 APC Any mutation 23 20 Signature R2 0.47 -0.12 1.06 1126.22 1.00 2 7 4 16 TRUE 0.95
colorectal cancer RAS_12-61 APC Any mutation 12 14 Signature U1 0.30 -0.31 0.84 1496.08 1.00 2 4 6 8 TRUE 0.50
melanoma RAS_12-61 APC Any mutation 149 102 Signature 7 -0.60 -1.11 -0.09 1463.88 1.00 241 126 79 23 TRUE 1.67
non-small cell lung cancer RAS_12-61 APC Any mutation 48 13 Signature 1A -0.20 -1.33 0.78 1633.16 1.00 207 46 11 2 TRUE 0.16
non-small cell lung cancer RAS_12-61 APC Any mutation 89 23 Signature 2 0.26 -0.49 1.09 1438.33 1.00 224 80 14 9 TRUE 0.29
non-small cell lung cancer RAS_12-61 APC Any mutation 275 50 Signature 4 -0.38 -0.97 0.17 1477.35 1.00 395 261 36 14 TRUE 0.70
uterine cancer RAS_12-61 APC Any mutation 9 63 Signature 10 1.52 -0.35 4.30 1339.71 1.00 17 0 54 9 TRUE 0.71
uterine cancer RAS_12-61 APC Any mutation 45 18 Signature 1A 0.38 -0.77 1.40 1328.48 1.00 166 40 13 5 TRUE 0.32
uterine cancer RAS_12-61 APC Any mutation 17 15 Signature 6 -0.28 -1.97 1.14 1322.65 1.00 72 15 13 2 TRUE 0.14
colorectal cancer RAS_12-61 APC Any mutation 1392 2462 Signature overall 0.35 0.08 0.63 1525.15 1.00 330 221 1291 1171 TRUE 1.88
melanoma RAS_12-61 APC Any mutation 149 102 Signature overall -0.43 -4.40 3.98 1447.56 1.00 241 126 79 23 TRUE 0.08
non-small cell lung cancer RAS_12-61 APC Any mutation 412 86 Signature overall -0.10 -1.04 0.84 1656.57 1.00 826 387 61 25 TRUE 0.08
uterine cancer RAS_12-61 APC Any mutation 71 96 Signature overall 0.54 -1.78 3.00 1338.73 1.00 255 55 80 16 TRUE 0.19
colorectal cancer RAS_12-61 ERBB2 Any mutation 369 47 Signature 1A -0.46 -1.02 0.07 1336.01 1.00 450 353 31 16 TRUE 0.98
colorectal cancer RAS_12-61 ERBB2 Any mutation 123 29 Signature 6 -0.40 -1.05 0.24 1125.53 1.00 172 114 20 9 TRUE 0.65
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 48 15 Signature 1A -0.86 -2.11 0.29 1565.49 1.00 205 46 13 2 TRUE 0.79
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 86 12 Signature 2 -1.12 -2.48 0.02 1413.99 1.00 227 85 11 1 TRUE 1.13
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 275 19 Signature 4 -1.02 -2.04 -0.11 1384.82 1.00 414 271 15 4 TRUE 1.38
colorectal cancer RAS_12-61 ERBB2 Any mutation 492 76 Signature overall -0.44 -1.27 0.40 1336.19 1.00 622 467 51 25 TRUE 0.50
non-small cell lung cancer RAS_12-61 ERBB2 Any mutation 409 46 Signature overall -0.99 -2.14 0.17 1362.05 1.00 846 402 39 7 TRUE 1.04
uterine cancer RAS_12-61 JAK1 Any mutation 29 14 Signature 15 1.03 0.09 2.01 1388.93 1.00 77 22 7 7 TRUE 1.45
uterine cancer RAS_12-61 JAK1 Any mutation 47 35 Signature 1A 1.05 0.34 1.82 1414.74 1.00 156 33 21 14 TRUE 2.29
uterine cancer RAS_12-61 JAK1 Any mutation 18 42 Signature 6 0.69 -0.20 1.57 1370.36 1.00 58 9 33 9 TRUE 0.89
uterine cancer RAS_12-61 JAK1 Any mutation 99 117 Signature overall 0.90 -0.11 1.99 1419.63 1.00 314 65 83 34 TRUE 1.05
colorectal cancer RAS_12-61 ARID2 Any mutation 13 16 Signature 10 -0.72 -1.99 0.44 1262.23 1.00 13 10 13 3 FALSE 0.63
colorectal cancer RAS_12-61 ARID2 Any mutation 173 19 Signature 15 -0.81 -1.75 0.01 1590.67 1.00 201 168 14 5 FALSE 1.11
colorectal cancer RAS_12-61 ARID2 Any mutation 370 42 Signature 1A -0.09 -0.68 0.52 1493.87 1.00 457 351 23 19 FALSE 0.11
colorectal cancer RAS_12-61 ARID2 Any mutation 123 27 Signature 6 -0.55 -1.35 0.17 1377.75 1.00 171 115 19 8 FALSE 0.77
melanoma RAS_12-61 ARID2 Any mutation 157 109 Signature 7 -0.04 -0.51 0.40 1305.21 1.00 249 121 73 36 FALSE 0.06
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 68 11 Signature 18 -0.11 -0.92 0.82 1435.39 1.00 77 62 5 6 FALSE 0.10
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 86 18 Signature 2 -0.26 -1.07 0.52 1398.32 1.00 226 81 13 5 FALSE 0.30
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 56 16 Signature 3 -0.52 -1.43 0.33 1519.32 1.00 173 54 14 2 FALSE 0.62
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 276 67 Signature 4 -0.55 -1.07 -0.05 1264.66 1.00 385 259 50 17 FALSE 1.44
colorectal cancer RAS_12-61 ARID2 Any mutation 679 104 Signature overall -0.51 -1.50 0.43 1486.52 1.00 842 644 69 35 FALSE 0.51
melanoma RAS_12-61 ARID2 Any mutation 161 128 Signature overall -1.24 -4.86 1.35 1411.62 1.00 263 125 92 36 FALSE 0.37
non-small cell lung cancer RAS_12-61 ARID2 Any mutation 486 112 Signature overall -0.37 -1.04 0.32 1467.37 1.00 861 456 82 30 FALSE 0.52
colorectal cancer RAS_12-61 MTOR Any mutation 13 12 Signature 10 -1.04 -2.55 0.08 1440.06 1.00 15 12 11 1 TRUE 0.89
colorectal cancer RAS_12-61 MTOR Any mutation 173 17 Signature 15 -0.39 -1.22 0.46 1338.98 1.00 204 166 10 7 TRUE 0.43
colorectal cancer RAS_12-61 MTOR Any mutation 372 48 Signature 1A -0.06 -0.62 0.48 1552.65 1.00 453 350 26 22 TRUE 0.09
colorectal cancer RAS_12-61 MTOR Any mutation 126 45 Signature 6 -0.63 -1.31 -0.01 1557.17 1.00 161 114 33 12 TRUE 1.23
non-small cell lung cancer RAS_12-61 MTOR Any mutation 275 41 Signature 4 -0.01 -0.68 0.61 1408.31 1.00 402 259 25 16 TRUE 0.01
colorectal cancer RAS_12-61 MTOR Any mutation 684 122 Signature overall -0.52 -1.53 0.41 1422.37 1.00 833 642 80 42 TRUE 0.55
non-small cell lung cancer RAS_12-61 MTOR Any mutation 275 41 Signature overall 0.08 -4.38 4.57 1397.77 1.00 402 259 25 16 TRUE 0.01
colorectal cancer RAS_12-61 NOTCH1 Any mutation 13 11 Signature 10 -1.94 -4.35 -0.30 1605.26 1.00 15 13 11 0 TRUE 1.33
colorectal cancer RAS_12-61 NOTCH1 Any mutation 175 17 Signature 15 -1.06 -2.19 -0.12 1400.66 1.00 203 171 13 4 TRUE 1.38
colorectal cancer RAS_12-61 NOTCH1 Any mutation 375 47 Signature 1A 0.13 -0.45 0.72 1363.63 1.00 454 351 23 24 TRUE 0.18
colorectal cancer RAS_12-61 NOTCH1 Any mutation 131 82 Signature 6 -0.51 -1.05 0.01 1698.99 1.00 146 106 57 25 TRUE 1.20
non-small cell lung cancer RAS_12-61 NOTCH1 Any mutation 86 12 Signature 2 -0.88 -2.23 0.35 1353.47 1.00 228 84 10 2 TRUE 0.76
non-small cell lung cancer RAS_12-61 NOTCH1 Any mutation 275 54 Signature 4 -0.98 -1.66 -0.30 1556.78 1.00 387 264 43 11 TRUE 2.28
colorectal cancer RAS_12-61 NOTCH1 Any mutation 694 157 Signature overall -0.85 -2.32 0.21 1600.24 1.00 818 641 104 53 TRUE 0.76
non-small cell lung cancer RAS_12-61 NOTCH1 Any mutation 361 66 Signature overall -0.92 -2.36 0.57 1410.62 1.00 615 348 53 13 TRUE 0.63
colorectal cancer RAS_12-61 SETD2 Any mutation 17 22 Signature 10 -0.65 -1.68 0.38 1411.69 1.00 13 11 16 6 FALSE 0.64
colorectal cancer RAS_12-61 SETD2 Any mutation 174 13 Signature 15 -1.11 -2.36 0.00 1417.35 1.00 203 171 10 3 FALSE 1.22
colorectal cancer RAS_12-61 SETD2 Any mutation 368 31 Signature 1A -0.63 -1.42 0.06 1470.74 1.00 458 358 21 10 FALSE 1.05
colorectal cancer RAS_12-61 SETD2 Any mutation 125 39 Signature 6 -1.01 -1.79 -0.29 1443.70 1.00 161 117 31 8 FALSE 2.05
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 16 16 Signature 13 0.02 -1.22 1.08 1516.60 1.00 72 13 13 3 FALSE 0.01
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 88 44 Signature 2 0.13 -0.51 0.79 1472.17 1.00 218 75 31 13 FALSE 0.16
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 57 15 Signature 3 -0.26 -1.36 0.76 1409.75 1.00 176 54 12 3 FALSE 0.20
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 278 55 Signature 4 -0.28 -0.87 0.25 1449.47 1.00 392 260 37 18 FALSE 0.49
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 158 14 Signature R2 -0.07 -1.02 0.96 1665.58 1.00 39 147 3 11 FALSE 0.05
colorectal cancer RAS_12-61 SETD2 Any mutation 684 105 Signature overall -0.83 -1.96 0.28 1213.41 1.00 835 657 78 27 FALSE 0.84
non-small cell lung cancer RAS_12-61 SETD2 Any mutation 597 144 Signature overall -0.09 -0.98 0.80 1463.44 1.00 897 549 96 48 FALSE 0.07
non-small cell lung cancer RAS_12-61 PBRM1 Any mutation 86 20 Signature 2 -0.33 -1.29 0.59 1439.94 1.00 228 81 15 5 TRUE 0.30
non-small cell lung cancer RAS_12-61 PBRM1 Any mutation 275 27 Signature 4 -0.75 -1.61 0.04 1457.29 1.00 407 269 21 6 TRUE 1.13
non-small cell lung cancer RAS_12-61 PBRM1 Any mutation 361 47 Signature overall -0.53 -2.01 0.85 1388.94 1.00 635 350 36 11 TRUE 0.35
colorectal cancer RAS_12-61 EPHA3 Any mutation 15 14 Signature 10 -0.14 -1.27 0.88 1289.02 1.00 17 11 10 4 FALSE 0.09
colorectal cancer RAS_12-61 EPHA3 Any mutation 173 13 Signature 15 -0.34 -1.32 0.51 1396.24 1.00 204 168 8 5 FALSE 0.33
colorectal cancer RAS_12-61 EPHA3 Any mutation 369 42 Signature 1A 0.21 -0.38 0.79 1319.32 1.00 458 347 20 22 FALSE 0.31
colorectal cancer RAS_12-61 EPHA3 Any mutation 124 26 Signature 6 -0.37 -1.20 0.34 1612.40 1.00 171 116 18 8 FALSE 0.45
melanoma RAS_12-61 EPHA3 Any mutation 151 97 Signature 7 0.15 -0.30 0.62 1323.88 1.00 254 117 63 34 FALSE 0.29
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 68 13 Signature 18 -0.21 -1.14 0.69 1500.44 1.00 75 63 8 5 FALSE 0.18
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 88 27 Signature 2 0.35 -0.41 1.06 1375.49 1.00 222 78 17 10 FALSE 0.44
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 57 18 Signature 3 0.48 -0.40 1.33 1330.49 1.00 177 50 11 7 FALSE 0.56
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 278 112 Signature 4 -0.13 -0.57 0.30 1514.96 1.00 363 238 72 40 FALSE 0.26
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 157 13 Signature R2 -0.29 -1.20 0.67 1403.79 1.00 38 148 4 9 FALSE 0.26
colorectal cancer RAS_12-61 EPHA3 Any mutation 681 95 Signature overall -0.16 -1.07 0.71 1423.93 1.00 850 642 56 39 FALSE 0.14
melanoma RAS_12-61 EPHA3 Any mutation 151 97 Signature overall 0.07 -4.42 4.20 1404.92 1.00 254 117 63 34 FALSE 0.01
non-small cell lung cancer RAS_12-61 EPHA3 Any mutation 648 183 Signature overall 0.04 -0.81 0.86 1410.74 1.00 875 577 112 71 FALSE 0.03
melanoma RAS_12-61 KDR Any mutation 151 121 Signature 7 -0.51 -1.00 -0.06 1361.53 1.00 231 122 92 29 TRUE 1.47
non-small cell lung cancer RAS_12-61 KDR Any mutation 86 12 Signature 2 0.43 -0.70 1.54 1515.26 1.00 231 81 7 5 TRUE 0.35
non-small cell lung cancer RAS_12-61 KDR Any mutation 57 11 Signature 3 0.92 -0.20 2.15 1492.04 1.00 182 51 5 6 TRUE 0.91
non-small cell lung cancer RAS_12-61 KDR Any mutation 276 76 Signature 4 -0.77 -1.36 -0.22 1469.03 1.00 373 259 59 17 TRUE 1.98
melanoma RAS_12-61 KDR Any mutation 151 121 Signature overall -0.39 -4.30 3.71 1443.56 1.00 231 122 92 29 TRUE 0.08
non-small cell lung cancer RAS_12-61 KDR Any mutation 419 99 Signature overall 0.20 -1.11 1.60 1580.19 1.00 786 391 71 28 TRUE 0.11
colorectal cancer RAS_12-61 PTCH1 Any mutation 13 11 Signature 10 -1.13 -2.56 0.00 1327.19 1.00 15 12 10 1 TRUE 1.07
colorectal cancer RAS_12-61 PTCH1 Any mutation 173 14 Signature 15 -0.89 -1.89 -0.02 1630.70 1.00 205 169 10 4 TRUE 1.25
colorectal cancer RAS_12-61 PTCH1 Any mutation 371 55 Signature 1A -0.52 -1.10 -0.01 1579.46 1.00 447 352 36 19 TRUE 1.21
colorectal cancer RAS_12-61 PTCH1 Any mutation 130 53 Signature 6 -0.71 -1.28 -0.13 1632.45 1.00 160 116 39 14 TRUE 1.78
colorectal cancer RAS_12-61 PTCH1 Any mutation 687 133 Signature overall -0.81 -1.77 0.03 1415.65 1.00 827 649 95 38 TRUE 1.16
colorectal cancer RAS_12-61 TET1 Any mutation 19 27 Signature 10 -0.59 -1.70 0.41 1414.38 1.00 12 11 19 8 FALSE 0.58
colorectal cancer RAS_12-61 TET1 Any mutation 169 18 Signature 15 -1.66 -3.00 -0.58 1377.05 1.00 196 167 16 2 FALSE 2.10
colorectal cancer RAS_12-61 TET1 Any mutation 357 25 Signature 1A -0.31 -1.10 0.46 1589.42 1.00 451 347 15 10 FALSE 0.35
colorectal cancer RAS_12-61 TET1 Any mutation 119 28 Signature 6 -0.60 -1.41 0.24 1358.14 1.00 167 111 20 8 FALSE 0.79
non-small cell lung cancer RAS_12-61 TET1 Any mutation 86 12 Signature 2 0.96 -0.26 2.19 1561.83 1.00 231 79 5 7 FALSE 0.93
non-small cell lung cancer RAS_12-61 TET1 Any mutation 278 60 Signature 4 -0.36 -0.95 0.20 1557.66 1.00 390 260 42 18 FALSE 0.68
colorectal cancer RAS_12-61 TET1 Any mutation 664 98 Signature overall -0.78 -2.04 0.45 1451.60 1.00 826 636 70 28 FALSE 0.66
non-small cell lung cancer RAS_12-61 TET1 Any mutation 364 72 Signature overall 0.23 -1.82 2.22 1670.97 1.00 621 339 47 25 FALSE 0.08
uterine cancer RAS_12-61 FGFR2 Any mutation 44 26 Signature 1A -2.10 -4.07 -0.70 1357.19 1.00 153 43 25 1 TRUE 1.90
uterine cancer RAS_12-61 FGFR2 Any mutation 17 22 Signature 6 -1.98 -3.94 -0.42 1416.72 1.00 63 16 21 1 TRUE 1.63
uterine cancer RAS_12-61 FGFR2 Any mutation 61 48 Signature overall -2.05 -4.16 -0.45 1540.66 1.00 216 59 46 2 TRUE 1.53
non-small cell lung cancer RAS_12-61 TBX3 Any mutation 275 75 Signature 4 -0.95 -1.56 -0.40 1386.64 1.00 376 259 59 16 FALSE 2.80
non-small cell lung cancer RAS_12-61 TBX3 Any mutation 156 15 Signature R2 -0.68 -1.68 0.37 1530.74 1.00 38 146 5 10 FALSE 0.71
non-small cell lung cancer RAS_12-61 TBX3 Any mutation 431 90 Signature overall -0.78 -2.62 1.25 1473.11 1.00 414 405 64 26 FALSE 0.38
colorectal cancer RAS_12-61 SMAD3 Any mutation 176 21 Signature 15 0.37 -0.17 0.88 1276.37 1.00 204 164 9 12 TRUE 0.79
colorectal cancer RAS_12-61 SMAD3 Any mutation 373 38 Signature 1A 0.35 -0.16 0.82 1169.31 1.00 460 352 17 21 TRUE 0.80
colorectal cancer RAS_12-61 SMAD3 Any mutation 124 20 Signature 6 0.34 -0.22 0.86 1193.36 1.00 176 116 12 8 TRUE 0.66
colorectal cancer RAS_12-61 SMAD3 Any mutation 673 79 Signature overall 0.36 -0.17 0.84 1160.93 1.00 840 632 38 41 TRUE 0.76
melanoma RAS_12-61 NTRK3 Any mutation 152 93 Signature 7 -0.50 -1.02 0.01 1006.38 1.00 244 129 70 23 FALSE 1.30
non-small cell lung cancer RAS_12-61 NTRK3 Any mutation 88 15 Signature 2 1.17 0.24 2.10 1553.89 1.00 232 79 6 9 FALSE 1.80
non-small cell lung cancer RAS_12-61 NTRK3 Any mutation 56 14 Signature 3 0.56 -0.52 1.57 1460.19 1.00 179 51 9 5 FALSE 0.54
non-small cell lung cancer RAS_12-61 NTRK3 Any mutation 279 105 Signature 4 -0.37 -0.84 0.07 1594.95 1.00 371 247 73 32 FALSE 0.96
non-small cell lung cancer RAS_12-61 NTRK3 Any mutation 157 18 Signature R2 0.78 -0.30 1.99 1656.07 1.00 40 141 2 16 FALSE 0.75
melanoma RAS_12-61 NTRK3 Any mutation 152 93 Signature overall -0.43 -4.24 3.87 1453.95 1.00 244 129 70 23 FALSE 0.09
non-small cell lung cancer RAS_12-61 NTRK3 Any mutation 580 152 Signature overall 0.52 -0.64 1.75 1495.88 1.00 822 518 90 62 FALSE 0.41
colorectal cancer RAS_12-61 GRIN2A Any mutation 14 18 Signature 10 -0.70 -1.89 0.45 1568.21 1.00 14 10 14 4 FALSE 0.64
colorectal cancer RAS_12-61 GRIN2A Any mutation 173 12 Signature 15 -1.00 -2.12 0.01 1421.96 1.00 206 170 9 3 FALSE 1.17
colorectal cancer RAS_12-61 GRIN2A Any mutation 369 43 Signature 1A -0.69 -1.35 -0.09 1447.67 1.00 447 356 30 13 FALSE 1.49
colorectal cancer RAS_12-61 GRIN2A Any mutation 123 43 Signature 6 -0.62 -1.28 0.00 1454.97 1.00 160 111 31 12 FALSE 1.22
melanoma RAS_12-61 GRIN2A Any mutation 16 13 Signature 11 -0.28 -1.47 0.90 1332.21 1.00 31 12 9 4 FALSE 0.20
melanoma RAS_12-61 GRIN2A Any mutation 167 278 Signature 7 -0.58 -0.95 -0.20 1486.56 1.00 181 102 213 65 FALSE 2.71
non-small cell lung cancer RAS_12-61 GRIN2A Any mutation 86 15 Signature 2 -0.58 -1.79 0.50 1441.34 1.00 226 83 12 3 FALSE 0.48
non-small cell lung cancer RAS_12-61 GRIN2A Any mutation 277 76 Signature 4 -0.73 -1.28 -0.21 1529.86 1.00 376 258 57 19 FALSE 2.10
non-small cell lung cancer RAS_12-61 GRIN2A Any mutation 156 13 Signature R2 -0.52 -1.54 0.59 1326.87 1.00 38 147 4 9 FALSE 0.47
colorectal cancer RAS_12-61 GRIN2A Any mutation 679 116 Signature overall -0.74 -1.84 0.25 1556.65 1.00 827 647 84 32 FALSE 0.80
melanoma RAS_12-61 GRIN2A Any mutation 183 291 Signature overall -0.44 -2.07 1.15 1576.97 1.00 212 114 222 69 FALSE 0.24
non-small cell lung cancer RAS_12-61 GRIN2A Any mutation 519 104 Signature overall -0.58 -1.90 0.69 1498.39 1.00 640 488 73 31 FALSE 0.43
uterine cancer RAS_12-61 CTCF Any mutation 27 18 Signature 15 0.73 -0.16 1.66 955.16 1.00 73 19 10 8 FALSE 0.96
uterine cancer RAS_12-61 CTCF Any mutation 46 49 Signature 1A 0.81 0.14 1.49 1504.15 1.00 145 29 32 17 FALSE 1.79
uterine cancer RAS_12-61 CTCF Any mutation 17 40 Signature 6 -0.10 -1.07 0.80 1594.10 1.00 49 12 35 5 FALSE 0.07
uterine cancer RAS_12-61 CTCF Any mutation 93 123 Signature overall 0.39 -0.57 1.31 1494.03 1.00 290 62 92 31 FALSE 0.40
non-small cell lung cancer RAS_12-61 STK11 Any mutation 23 11 Signature 11 1.62 0.69 2.58 1286.46 1.00 20 13 1 10 TRUE 3.15
non-small cell lung cancer RAS_12-61 STK11 Any mutation 32 19 Signature 15 1.43 0.58 2.27 1474.23 1.00 96 21 8 11 TRUE 3.26
non-small cell lung cancer RAS_12-61 STK11 Any mutation 10 11 Signature 16 0.61 -0.44 1.64 1656.09 1.00 41 8 9 2 TRUE 0.61
non-small cell lung cancer RAS_12-61 STK11 Any mutation 69 38 Signature 18 0.95 0.31 1.58 1455.24 1.00 68 46 15 23 TRUE 2.41
non-small cell lung cancer RAS_12-61 STK11 Any mutation 17 17 Signature 19 0.84 -0.01 1.75 1366.81 1.00 35 11 11 6 TRUE 1.25
non-small cell lung cancer RAS_12-61 STK11 Any mutation 48 21 Signature 1A 1.68 0.89 2.46 1413.45 1.00 210 35 8 13 TRUE 4.66
non-small cell lung cancer RAS_12-61 STK11 Any mutation 87 55 Signature 2 0.35 -0.23 0.92 1482.86 1.00 207 71 39 16 TRUE 0.61
non-small cell lung cancer RAS_12-61 STK11 Any mutation 16 13 Signature 20 1.60 0.66 2.55 1473.71 1.00 56 8 5 8 TRUE 3.16
non-small cell lung cancer RAS_12-61 STK11 Any mutation 56 37 Signature 3 0.88 0.25 1.55 1464.76 1.00 164 42 23 14 TRUE 2.16
non-small cell lung cancer RAS_12-61 STK11 Any mutation 276 163 Signature 4 0.46 0.12 0.79 1528.49 1.00 341 200 87 76 TRUE 2.10
non-small cell lung cancer RAS_12-61 STK11 Any mutation 30 13 Signature 8 0.96 0.09 1.86 1396.13 1.00 29 22 5 8 TRUE 1.51
non-small cell lung cancer RAS_12-61 STK11 Any mutation 157 61 Signature R2 0.96 0.30 1.64 1487.73 1.00 33 105 9 52 TRUE 2.27
non-small cell lung cancer RAS_12-61 STK11 Any mutation 23 13 Signature U1 1.33 0.47 2.24 1555.49 1.00 82 16 6 7 TRUE 2.53
non-small cell lung cancer RAS_12-61 STK11 Any mutation 844 472 Signature overall 1.05 0.59 1.54 1281.52 1.00 1382 598 226 246 TRUE 4.72
colorectal cancer RAS_12-61 ASXL1 Any mutation 13 11 Signature 10 -1.04 -2.71 0.26 1589.98 1.00 13 12 10 1 TRUE 0.76
colorectal cancer RAS_12-61 ASXL1 Any mutation 173 14 Signature 15 -0.53 -1.50 0.36 1527.47 1.00 205 168 9 5 TRUE 0.57
colorectal cancer RAS_12-61 ASXL1 Any mutation 368 31 Signature 1A -0.46 -1.18 0.21 1464.59 1.00 459 357 20 11 TRUE 0.70
colorectal cancer RAS_12-61 ASXL1 Any mutation 126 34 Signature 6 0.07 -0.58 0.74 1304.96 1.00 171 111 19 15 TRUE 0.08
colorectal cancer RAS_12-61 ASXL1 Any mutation 680 90 Signature overall -0.50 -1.58 0.49 1621.38 1.00 848 648 58 32 TRUE 0.48
colorectal cancer RAS_12-61 EP300 Any mutation 174 18 Signature 15 -0.70 -1.51 0.11 1216.29 1.00 202 169 13 5 TRUE 1.08
colorectal cancer RAS_12-61 EP300 Any mutation 368 36 Signature 1A -0.34 -0.98 0.30 1399.08 1.00 457 354 22 14 TRUE 0.56
colorectal cancer RAS_12-61 EP300 Any mutation 128 51 Signature 6 -0.46 -1.07 0.14 1334.25 1.00 162 113 36 15 TRUE 0.85
non-small cell lung cancer RAS_12-61 EP300 Any mutation 15 11 Signature 13 -0.09 -1.38 1.07 1393.41 1.00 76 13 9 2 TRUE 0.06
non-small cell lung cancer RAS_12-61 EP300 Any mutation 87 20 Signature 2 -0.51 -1.51 0.36 1613.61 1.00 226 84 17 3 TRUE 0.55
non-small cell lung cancer RAS_12-61 EP300 Any mutation 276 30 Signature 4 -0.10 -0.81 0.60 1355.19 1.00 409 264 18 12 TRUE 0.11
uterine cancer RAS_12-61 EP300 Any mutation 45 21 Signature 1A 0.38 -0.59 1.37 1508.42 1.00 160 39 15 6 TRUE 0.36
uterine cancer RAS_12-61 EP300 Any mutation 17 20 Signature 6 0.26 -0.95 1.36 1384.46 1.00 67 13 16 4 TRUE 0.18
colorectal cancer RAS_12-61 EP300 Any mutation 670 105 Signature overall -0.49 -1.49 0.38 1312.41 1.00 821 636 71 34 TRUE 0.53
non-small cell lung cancer RAS_12-61 EP300 Any mutation 378 61 Signature overall -0.24 -1.25 0.76 1462.41 1.00 711 361 44 17 TRUE 0.18
uterine cancer RAS_12-61 EP300 Any mutation 67 74 Signature overall 0.42 -1.21 2.17 1428.57 1.00 247 53 60 14 TRUE 0.21
colorectal cancer RAS_12-61 ERBB4 Any mutation 17 18 Signature 10 -0.06 -1.05 0.90 1316.84 1.00 14 11 12 6 TRUE 0.04
colorectal cancer RAS_12-61 ERBB4 Any mutation 174 23 Signature 15 -0.38 -1.17 0.36 1346.05 1.00 199 166 15 8 TRUE 0.47
colorectal cancer RAS_12-61 ERBB4 Any mutation 369 43 Signature 1A -0.04 -0.60 0.56 1522.65 1.00 455 350 24 19 TRUE 0.05
colorectal cancer RAS_12-61 ERBB4 Any mutation 125 31 Signature 6 0.26 -0.41 0.94 1560.58 1.00 174 110 16 15 TRUE 0.35
melanoma RAS_12-61 ERBB4 Any mutation 160 171 Signature 7 -0.60 -1.00 -0.22 964.18 1.00 207 119 130 41 TRUE 2.43
non-small cell lung cancer RAS_12-61 ERBB4 Any mutation 48 11 Signature 1A 0.30 -0.90 1.44 1498.59 1.00 211 44 7 4 TRUE 0.21
non-small cell lung cancer RAS_12-61 ERBB4 Any mutation 86 17 Signature 2 -0.74 -2.08 0.24 1388.23 1.00 226 84 15 2 TRUE 0.66
non-small cell lung cancer RAS_12-61 ERBB4 Any mutation 279 97 Signature 4 -0.36 -0.80 0.07 1555.24 1.00 375 249 67 30 TRUE 0.97
colorectal cancer RAS_12-61 ERBB4 Any mutation 685 115 Signature overall -0.05 -0.96 0.83 1471.74 1.00 842 637 67 48 TRUE 0.04
melanoma RAS_12-61 ERBB4 Any mutation 160 171 Signature overall -0.52 -4.26 3.41 1485.83 1.00 207 119 130 41 TRUE 0.11
non-small cell lung cancer RAS_12-61 ERBB4 Any mutation 413 125 Signature overall -0.29 -1.45 0.92 1561.85 1.00 812 377 89 36 TRUE 0.20
colorectal cancer RAS_12-61 MED12 Any mutation 173 11 Signature 15 -1.00 -2.25 0.02 1291.67 1.00 204 171 9 2 TRUE 1.05
colorectal cancer RAS_12-61 MED12 Any mutation 369 34 Signature 1A 0.17 -0.48 0.84 1446.27 1.00 463 351 16 18 TRUE 0.21
colorectal cancer RAS_12-61 MED12 Any mutation 127 42 Signature 6 -0.59 -1.27 0.06 1678.43 1.00 164 116 31 11 TRUE 1.05
non-small cell lung cancer RAS_12-61 MED12 Any mutation 86 25 Signature 2 -0.36 -1.21 0.45 1440.02 1.00 220 80 19 6 TRUE 0.40
non-small cell lung cancer RAS_12-61 MED12 Any mutation 277 72 Signature 4 -0.58 -1.12 -0.06 1371.65 1.00 382 258 53 19 TRUE 1.52
uterine cancer RAS_12-61 MED12 Any mutation 26 13 Signature 15 -0.42 -1.79 0.81 1277.19 1.00 72 23 10 3 TRUE 0.28
uterine cancer RAS_12-61 MED12 Any mutation 44 18 Signature 1A -0.94 -2.50 0.32 1485.37 1.00 160 42 16 2 TRUE 0.73
uterine cancer RAS_12-61 MED12 Any mutation 17 14 Signature 6 -1.11 -2.87 0.42 1395.70 1.00 71 16 13 1 TRUE 0.76
colorectal cancer RAS_12-61 MED12 Any mutation 669 87 Signature overall -0.47 -1.60 0.53 1603.22 1.00 831 638 56 31 TRUE 0.41
non-small cell lung cancer RAS_12-61 MED12 Any mutation 363 97 Signature overall -0.47 -1.51 0.66 1536.43 1.00 602 338 72 25 TRUE 0.40
uterine cancer RAS_12-61 MED12 Any mutation 91 87 Signature overall -0.86 -2.33 0.56 1438.08 1.00 319 83 79 8 TRUE 0.61
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 15 11 Signature 13 0.67 -0.29 1.61 1428.92 1.00 76 12 8 3 FALSE 0.75
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 33 11 Signature 15 0.77 -0.16 1.66 1420.60 1.00 99 28 6 5 FALSE 1.02
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 69 17 Signature 18 0.48 -0.34 1.27 1544.43 1.00 74 60 8 9 FALSE 0.62
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 48 21 Signature 1A 0.73 -0.02 1.52 1397.01 1.00 204 41 14 7 FALSE 1.18
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 86 32 Signature 2 0.89 0.23 1.56 1513.34 1.00 221 71 17 15 FALSE 2.12
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 58 30 Signature 3 0.45 -0.27 1.12 1504.81 1.00 167 49 21 9 FALSE 0.67
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 281 128 Signature 4 0.79 0.41 1.16 1722.65 1.00 374 211 58 70 FALSE 4.49
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 156 20 Signature R2 0.40 -0.39 1.20 1537.86 1.00 38 140 4 16 FALSE 0.47
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 23 15 Signature U1 0.70 -0.14 1.57 1517.35 1.00 79 18 10 5 FALSE 0.94
non-small cell lung cancer RAS_12-61 RBM10 Any mutation 769 285 Signature overall 0.65 0.12 1.20 1379.80 1.00 1332 630 146 139 FALSE 1.80
colorectal cancer RAS_12-61 NF1 Any mutation 16 24 Signature 10 -0.98 -2.16 0.09 1542.03 1.00 13 11 19 5 TRUE 1.10
colorectal cancer RAS_12-61 NF1 Any mutation 173 21 Signature 15 -1.54 -2.66 -0.61 1466.52 1.00 198 170 18 3 TRUE 2.46
colorectal cancer RAS_12-61 NF1 Any mutation 370 40 Signature 1A -0.32 -0.99 0.32 1549.15 1.00 456 354 24 16 TRUE 0.49
colorectal cancer RAS_12-61 NF1 Any mutation 123 44 Signature 6 -1.29 -2.13 -0.56 1438.31 1.00 162 116 37 7 TRUE 2.79
melanoma RAS_12-61 NF1 Any mutation 16 17 Signature 11 -0.95 -2.06 0.06 1287.75 1.01 31 13 14 3 TRUE 1.18
melanoma RAS_12-61 NF1 Any mutation 160 242 Signature 7 -0.97 -1.36 -0.59 279.91 1.01 177 114 196 46 TRUE 5.74
non-small cell lung cancer RAS_12-61 NF1 Any mutation 68 13 Signature 18 -0.26 -1.23 0.66 1510.35 1.00 76 62 7 6 TRUE 0.24
non-small cell lung cancer RAS_12-61 NF1 Any mutation 48 13 Signature 1A -0.59 -1.69 0.54 1124.98 1.00 207 46 11 2 TRUE 0.53
non-small cell lung cancer RAS_12-61 NF1 Any mutation 88 39 Signature 2 -0.48 -1.23 0.19 1575.79 1.00 210 80 31 8 TRUE 0.74
non-small cell lung cancer RAS_12-61 NF1 Any mutation 16 13 Signature 20 -0.60 -1.83 0.56 1508.01 1.00 51 14 11 2 TRUE 0.50
non-small cell lung cancer RAS_12-61 NF1 Any mutation 56 15 Signature 3 -1.06 -2.36 0.00 1548.99 1.00 174 55 14 1 TRUE 1.12
non-small cell lung cancer RAS_12-61 NF1 Any mutation 278 113 Signature 4 -0.53 -0.96 -0.11 1216.73 1.00 368 246 81 32 TRUE 1.86
non-small cell lung cancer RAS_12-61 NF1 Any mutation 25 11 Signature 7 -1.25 -2.67 -0.04 1546.56 1.00 72 25 11 0 TRUE 1.19
non-small cell lung cancer RAS_12-61 NF1 Any mutation 157 12 Signature R2 -0.65 -1.58 0.25 1481.32 1.00 38 149 4 8 TRUE 0.76
uterine cancer RAS_12-61 NF1 Any mutation 46 21 Signature 1A 0.33 -0.68 1.25 1532.62 1.00 163 40 15 6 TRUE 0.30
uterine cancer RAS_12-61 NF1 Any mutation 17 24 Signature 6 -0.36 -1.68 0.83 1552.29 1.00 64 14 21 3 TRUE 0.25
colorectal cancer RAS_12-61 NF1 Any mutation 682 129 Signature overall -1.03 -2.19 0.05 1640.40 1.00 829 651 98 31 TRUE 1.18
melanoma RAS_12-61 NF1 Any mutation 176 259 Signature overall -0.95 -2.21 0.36 1451.92 1.00 208 127 210 49 TRUE 0.94
non-small cell lung cancer RAS_12-61 NF1 Any mutation 736 229 Signature overall -0.69 -1.36 -0.05 1431.27 1.00 1196 677 170 59 TRUE 1.35
uterine cancer RAS_12-61 NF1 Any mutation 67 92 Signature overall -0.06 -1.90 1.79 1388.38 1.00 244 55 80 12 TRUE 0.02
melanoma RAS_12-61 FLT1 Any mutation 154 110 Signature 7 -0.17 -0.64 0.27 1353.17 1.00 241 121 77 33 FALSE 0.32
non-small cell lung cancer RAS_12-61 FLT1 Any mutation 69 13 Signature 18 0.46 -0.42 1.41 1043.62 1.00 77 61 5 8 FALSE 0.48
non-small cell lung cancer RAS_12-61 FLT1 Any mutation 86 12 Signature 2 0.31 -0.60 1.28 1480.77 1.00 231 81 7 5 FALSE 0.28
non-small cell lung cancer RAS_12-61 FLT1 Any mutation 278 64 Signature 4 -0.16 -0.68 0.35 1387.83 1.00 391 257 43 21 FALSE 0.28
melanoma RAS_12-61 FLT1 Any mutation 154 110 Signature overall -0.27 -4.85 4.13 1365.98 1.00 241 121 77 33 FALSE 0.05
non-small cell lung cancer RAS_12-61 FLT1 Any mutation 433 89 Signature overall 0.19 -0.66 1.16 1495.73 1.00 699 399 55 34 FALSE 0.17
uterine cancer RAS_12-61 RASA1 Any mutation 44 20 Signature 1A -2.19 -4.62 -0.41 1543.21 1.00 161 43 19 1 FALSE 1.39
uterine cancer RAS_12-61 RASA1 Any mutation 17 12 Signature 6 -1.84 -4.48 0.33 1520.51 1.00 71 16 11 1 FALSE 0.89
uterine cancer RAS_12-61 RASA1 Any mutation 64 78 Signature overall -2.43 -5.14 -0.25 1438.96 1.00 247 62 76 2 FALSE 1.26
colorectal cancer RAS_12-61 EPHA5 Any mutation 16 26 Signature 10 -1.38 -2.59 -0.27 1548.76 1.00 11 12 22 4 FALSE 1.68
colorectal cancer RAS_12-61 EPHA5 Any mutation 173 18 Signature 15 -1.15 -2.26 -0.18 1569.85 1.00 202 169 14 4 FALSE 1.49
colorectal cancer RAS_12-61 EPHA5 Any mutation 369 49 Signature 1A -0.08 -0.66 0.47 1656.43 1.00 451 347 27 22 FALSE 0.11
colorectal cancer RAS_12-61 EPHA5 Any mutation 123 36 Signature 6 -1.25 -2.13 -0.45 1366.32 1.00 163 117 30 6 FALSE 2.59
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 69 24 Signature 18 0.27 -0.51 1.02 1443.46 1.00 71 57 12 12 FALSE 0.31
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 87 30 Signature 2 0.54 -0.20 1.24 1319.15 1.00 222 75 18 12 FALSE 0.82
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 56 19 Signature 3 0.67 -0.18 1.50 1535.68 1.00 179 48 11 8 FALSE 0.92
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 278 109 Signature 4 0.03 -0.41 0.44 1380.58 1.00 372 236 67 42 FALSE 0.05
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 156 12 Signature R2 -0.32 -1.23 0.62 1464.90 1.00 39 148 4 8 FALSE 0.29
colorectal cancer RAS_12-61 EPHA5 Any mutation 681 129 Signature overall -0.95 -2.33 0.34 1398.12 1.00 827 645 93 36 FALSE 0.86
non-small cell lung cancer RAS_12-61 EPHA5 Any mutation 646 194 Signature overall 0.24 -0.52 1.05 1381.38 1.00 883 564 112 82 FALSE 0.27
colorectal cancer RAS_12-61 AR Any mutation 174 21 Signature 15 -0.65 -1.41 0.03 1503.48 1.00 200 168 15 6 TRUE 1.13
colorectal cancer RAS_12-61 AR Any mutation 368 33 Signature 1A -0.54 -1.17 0.04 1176.42 1.00 455 357 22 11 TRUE 1.12
colorectal cancer RAS_12-61 AR Any mutation 125 37 Signature 6 -0.37 -0.97 0.27 1499.47 1.00 166 113 25 12 TRUE 0.62
non-small cell lung cancer RAS_12-61 AR Any mutation 277 56 Signature 4 -0.32 -0.89 0.21 76.12 1.04 394 259 38 18 TRUE 0.54
colorectal cancer RAS_12-61 AR Any mutation 667 91 Signature overall -0.52 -1.24 0.17 1397.49 1.00 821 638 62 29 TRUE 0.81
non-small cell lung cancer RAS_12-61 AR Any mutation 277 56 Signature overall -0.19 -4.40 4.54 1345.73 1.00 394 259 38 18 TRUE 0.03
colorectal cancer RAS_12-61 ROS1 Any mutation 19 30 Signature 10 -0.77 -1.83 0.27 1434.75 1.00 12 11 22 8 TRUE 0.83
colorectal cancer RAS_12-61 ROS1 Any mutation 368 28 Signature 1A -0.59 -1.41 0.20 1456.61 1.00 460 359 19 9 TRUE 0.85
colorectal cancer RAS_12-61 ROS1 Any mutation 123 26 Signature 6 -0.88 -1.82 0.00 1048.69 1.00 168 117 20 6 TRUE 1.26
melanoma RAS_12-61 ROS1 Any mutation 16 11 Signature 11 0.34 -0.83 1.71 1491.68 1.00 33 11 6 5 TRUE 0.21
melanoma RAS_12-61 ROS1 Any mutation 160 231 Signature 7 -0.57 -0.96 -0.19 1181.68 1.00 195 107 178 53 TRUE 2.55
non-small cell lung cancer RAS_12-61 ROS1 Any mutation 86 14 Signature 2 -1.10 -2.35 0.13 1532.73 1.00 227 84 12 2 TRUE 1.11
non-small cell lung cancer RAS_12-61 ROS1 Any mutation 275 42 Signature 4 -1.21 -2.07 -0.49 1237.01 1.00 394 268 35 7 TRUE 2.45
colorectal cancer RAS_12-61 ROS1 Any mutation 510 84 Signature overall -0.70 -2.35 0.99 1346.33 1.01 640 487 61 23 TRUE 0.40
melanoma RAS_12-61 ROS1 Any mutation 176 242 Signature overall -0.12 -1.93 1.87 1525.45 1.00 228 118 184 58 TRUE 0.05
non-small cell lung cancer RAS_12-61 ROS1 Any mutation 361 56 Signature overall -1.13 -2.51 0.29 1610.46 1.00 621 352 47 9 TRUE 0.90
colorectal cancer RAS_12-61 PIK3CG Any mutation 16 22 Signature 10 -0.53 -1.65 0.50 1393.13 1.00 12 10 16 6 FALSE 0.46
colorectal cancer RAS_12-61 PIK3CG Any mutation 173 17 Signature 15 -0.55 -1.51 0.30 1387.47 1.00 203 167 11 6 FALSE 0.62
colorectal cancer RAS_12-61 PIK3CG Any mutation 368 29 Signature 1A -0.77 -1.56 -0.02 1487.61 1.00 456 360 21 8 FALSE 1.27
colorectal cancer RAS_12-61 PIK3CG Any mutation 124 29 Signature 6 -0.32 -1.12 0.45 1458.93 1.00 171 114 19 10 FALSE 0.39
melanoma RAS_12-61 PIK3CG Any mutation 151 92 Signature 7 -0.64 -1.21 0.10 281.85 1.00 250 131 72 20 FALSE 1.50
non-small cell lung cancer RAS_12-61 PIK3CG Any mutation 15 13 Signature 13 -0.76 -2.60 0.75 1371.12 1.00 72 14 12 1 FALSE 0.43
non-small cell lung cancer RAS_12-61 PIK3CG Any mutation 88 18 Signature 2 1.42 0.48 2.39 1350.87 1.00 232 76 6 12 FALSE 2.44
non-small cell lung cancer RAS_12-61 PIK3CG Any mutation 276 75 Signature 4 -0.34 -0.84 0.18 1607.27 1.00 382 252 51 24 FALSE 0.71
non-small cell lung cancer RAS_12-61 PIK3CG Any mutation 156 12 Signature R2 -1.40 -2.57 -0.34 1377.79 1.00 36 151 7 5 FALSE 1.85
colorectal cancer RAS_12-61 PIK3CG Any mutation 681 97 Signature overall -0.56 -1.74 0.50 1639.98 1.00 842 651 67 30 FALSE 0.49
melanoma RAS_12-61 PIK3CG Any mutation 151 92 Signature overall -0.50 -4.77 3.79 1203.51 1.00 250 131 72 20 FALSE 0.10
non-small cell lung cancer RAS_12-61 PIK3CG Any mutation 535 118 Signature overall -0.26 -1.73 1.18 1251.78 1.00 722 493 76 42 FALSE 0.14
non-small cell lung cancer RAS_12-61 EGFR Any mutation 15 23 Signature 13 -3.09 -4.10 -2.10 1472.16 1.00 63 14 22 1 TRUE 8.60
non-small cell lung cancer RAS_12-61 EGFR Any mutation 21 12 Signature 14 -3.09 -4.06 -2.17 1561.41 1.00 26 20 11 1 TRUE 9.60
non-small cell lung cancer RAS_12-61 EGFR Any mutation 33 54 Signature 15 -2.90 -3.80 -1.99 1516.48 1.00 61 30 51 3 TRUE 10.15
non-small cell lung cancer RAS_12-61 EGFR Any mutation 10 19 Signature 16 -3.27 -4.28 -2.32 1209.39 1.00 32 10 19 0 TRUE 9.99
non-small cell lung cancer RAS_12-61 EGFR Any mutation 19 21 Signature 17 -3.18 -4.20 -2.23 1461.93 1.00 13 18 20 1 TRUE 9.49
non-small cell lung cancer RAS_12-61 EGFR Any mutation 68 29 Signature 18 -3.45 -4.45 -2.59 1598.46 1.00 57 68 29 0 TRUE 12.06
non-small cell lung cancer RAS_12-61 EGFR Any mutation 16 16 Signature 19 -3.25 -4.32 -2.32 1369.05 1.00 31 16 16 0 TRUE 9.67
non-small cell lung cancer RAS_12-61 EGFR Any mutation 48 197 Signature 1A -3.71 -4.69 -2.87 1707.74 1.00 93 48 197 0 TRUE 14.73
non-small cell lung cancer RAS_12-61 EGFR Any mutation 86 79 Signature 2 -3.32 -4.27 -2.44 1434.18 1.00 176 85 78 1 TRUE 11.80
non-small cell lung cancer RAS_12-61 EGFR Any mutation 16 35 Signature 20 -3.35 -4.39 -2.38 1527.73 1.00 33 16 35 0 TRUE 10.08
non-small cell lung cancer RAS_12-61 EGFR Any mutation 11 29 Signature 21 -3.30 -4.30 -2.33 1519.32 1.00 29 11 29 0 TRUE 10.06
non-small cell lung cancer RAS_12-61 EGFR Any mutation 56 89 Signature 3 -2.90 -3.73 -2.06 1479.79 1.00 110 52 85 4 TRUE 11.47
non-small cell lung cancer RAS_12-61 EGFR Any mutation 275 114 Signature 4 -2.67 -3.36 -2.01 1644.60 1.00 343 266 105 9 TRUE 14.20
non-small cell lung cancer RAS_12-61 EGFR Any mutation 13 18 Signature 6 -3.08 -4.08 -2.12 1491.17 1.00 28 12 17 1 TRUE 9.49
non-small cell lung cancer RAS_12-61 EGFR Any mutation 25 34 Signature 7 -3.35 -4.33 -2.40 1506.40 1.00 53 25 34 0 TRUE 10.80
non-small cell lung cancer RAS_12-61 EGFR Any mutation 29 14 Signature 8 -3.14 -4.08 -2.19 1593.70 1.00 22 28 13 1 TRUE 10.02
non-small cell lung cancer RAS_12-61 EGFR Any mutation 7 11 Signature R3 -3.26 -4.33 -2.24 1738.32 1.00 14 7 11 0 TRUE 8.67
non-small cell lung cancer RAS_12-61 EGFR Any mutation 23 46 Signature U1 -3.38 -4.40 -2.49 1384.92 1.00 47 23 46 0 TRUE 10.87
non-small cell lung cancer RAS_12-61 EGFR Any mutation 775 853 Signature overall -3.21 -3.78 -2.70 1452.32 1.00 1245 753 831 22 TRUE 31.05
colorectal cancer RAS_12-61 ARID1B Any mutation 173 22 Signature 15 -1.10 -1.88 -0.31 1402.04 1.00 200 167 16 6 TRUE 2.24
colorectal cancer RAS_12-61 ARID1B Any mutation 369 53 Signature 1A -1.05 -1.67 -0.45 1711.02 1.00 445 356 40 13 TRUE 3.22
colorectal cancer RAS_12-61 ARID1B Any mutation 123 46 Signature 6 -1.49 -2.31 -0.79 1330.70 1.01 155 118 41 5 TRUE 3.75
non-small cell lung cancer RAS_12-61 ARID1B Any mutation 86 13 Signature 2 0.08 -0.97 1.20 1419.98 1.00 230 81 8 5 TRUE 0.05
non-small cell lung cancer RAS_12-61 ARID1B Any mutation 275 42 Signature 4 -0.76 -1.53 -0.05 1466.38 1.00 396 266 33 9 TRUE 1.36
uterine cancer RAS_12-61 ARID1B Any mutation 44 17 Signature 1A 0.34 -0.72 1.32 1502.32 1.00 164 39 12 5 TRUE 0.29
uterine cancer RAS_12-61 ARID1B Any mutation 18 39 Signature 6 -0.09 -1.05 0.92 1643.06 1.00 55 12 33 6 TRUE 0.06
colorectal cancer RAS_12-61 ARID1B Any mutation 665 121 Signature overall -1.19 -1.96 -0.43 1420.47 1.00 800 641 97 24 TRUE 2.71
non-small cell lung cancer RAS_12-61 ARID1B Any mutation 361 55 Signature overall -0.33 -1.75 1.40 1317.13 1.00 626 347 41 14 TRUE 0.16
uterine cancer RAS_12-61 ARID1B Any mutation 65 78 Signature overall 0.17 -1.37 1.69 1250.96 1.00 245 52 65 13 TRUE 0.09
non-small cell lung cancer RAS_12-61 MET Any mutation 86 23 Signature 2 -0.92 -1.92 -0.08 1520.32 1.00 220 84 21 2 TRUE 1.25
non-small cell lung cancer RAS_12-61 MET Any mutation 56 11 Signature 3 -0.70 -1.81 0.26 1559.43 1.00 179 54 9 2 TRUE 0.78
non-small cell lung cancer RAS_12-61 MET Any mutation 275 34 Signature 4 -0.61 -1.31 0.06 1412.37 1.00 407 265 24 10 TRUE 1.07
non-small cell lung cancer RAS_12-61 MET Any mutation 417 68 Signature overall -0.75 -1.69 0.09 1483.70 1.00 806 403 54 14 TRUE 1.01
colorectal cancer RAS_12-61 BRAF Any mutation 173 48 Signature 15 -2.10 -2.71 -1.52 1547.74 1.00 172 167 42 6 TRUE 11.79
colorectal cancer RAS_12-61 BRAF Any mutation 369 99 Signature 1A -2.11 -2.66 -1.61 1302.09 1.00 391 358 88 11 TRUE 14.54
colorectal cancer RAS_12-61 BRAF Any mutation 125 60 Signature 6 -2.19 -2.84 -1.61 1180.92 1.00 136 121 56 4 TRUE 11.64
melanoma RAS_12-61 BRAF Any mutation 16 25 Signature 11 -1.86 -3.18 -0.78 1458.49 1.00 18 13 22 3 TRUE 2.69
melanoma RAS_12-61 BRAF Any mutation 12 11 Signature 1A -2.38 -4.52 -0.92 1488.02 1.00 40 12 11 0 TRUE 1.97
melanoma RAS_12-61 BRAF Any mutation 151 191 Signature 7 -1.99 -2.54 -1.51 1506.42 1.00 144 130 170 21 TRUE 14.35
non-small cell lung cancer RAS_12-61 BRAF Any mutation 68 11 Signature 18 -1.10 -2.17 -0.27 1710.94 1.00 72 67 10 1 TRUE 1.67
non-small cell lung cancer RAS_12-61 BRAF Any mutation 86 20 Signature 2 -0.90 -1.74 -0.16 1545.11 1.00 221 83 17 3 TRUE 1.54
non-small cell lung cancer RAS_12-61 BRAF Any mutation 56 20 Signature 3 -0.84 -1.78 -0.03 1601.35 1.00 170 53 17 3 TRUE 1.31
non-small cell lung cancer RAS_12-61 BRAF Any mutation 275 50 Signature 4 -0.77 -1.33 -0.20 1381.40 1.00 392 262 37 13 TRUE 2.09
colorectal cancer RAS_12-61 BRAF Any mutation 667 207 Signature overall -2.13 -2.69 -1.61 1409.86 1.00 699 646 186 21 TRUE 13.17
melanoma RAS_12-61 BRAF Any mutation 179 227 Signature overall -2.06 -3.55 -0.78 1610.25 1.00 202 155 203 24 TRUE 2.66
non-small cell lung cancer RAS_12-61 BRAF Any mutation 485 101 Signature overall -0.90 -1.64 -0.23 1494.46 1.00 855 465 81 20 TRUE 1.99
colorectal cancer RAS_12-61 B2M Any mutation 14 14 Signature 10 -0.94 -2.25 0.14 1604.09 1.00 15 12 12 2 FALSE 0.93
colorectal cancer RAS_12-61 B2M Any mutation 171 20 Signature 15 -0.93 -1.79 -0.10 1591.60 1.00 198 166 15 5 FALSE 1.48
colorectal cancer RAS_12-61 B2M Any mutation 361 46 Signature 1A -0.59 -1.20 -0.03 1568.59 1.00 447 346 31 15 FALSE 1.32
colorectal cancer RAS_12-61 B2M Any mutation 126 51 Signature 6 -0.38 -0.95 0.22 1196.92 1.00 161 109 34 17 FALSE 0.68
colorectal cancer RAS_12-61 B2M Any mutation 672 131 Signature overall -0.71 -1.66 0.17 1585.75 1.00 821 633 92 39 FALSE 0.94
colorectal cancer RAS_12-61 CARD11 Any mutation 173 14 Signature 15 -0.41 -1.20 0.35 1385.04 1.00 203 168 9 5 FALSE 0.54
colorectal cancer RAS_12-61 CARD11 Any mutation 371 58 Signature 1A -0.09 -0.61 0.37 1457.09 1.00 447 345 32 26 FALSE 0.14
colorectal cancer RAS_12-61 CARD11 Any mutation 125 38 Signature 6 -0.34 -1.00 0.26 1336.06 1.00 167 114 27 11 FALSE 0.51
melanoma RAS_12-61 CARD11 Any mutation 148 107 Signature 7 -0.74 -1.26 -0.23 1483.01 1.00 234 126 85 22 FALSE 2.46
non-small cell lung cancer RAS_12-61 CARD11 Any mutation 88 16 Signature 2 0.43 -0.43 1.45 1308.95 1.00 229 81 9 7 FALSE 0.42
non-small cell lung cancer RAS_12-61 CARD11 Any mutation 275 63 Signature 4 -0.03 -0.55 0.49 1175.05 1.00 391 252 40 23 FALSE 0.04
colorectal cancer RAS_12-61 CARD11 Any mutation 669 110 Signature overall -0.28 -0.99 0.39 1464.85 1.00 817 627 68 42 FALSE 0.38
melanoma RAS_12-61 CARD11 Any mutation 148 107 Signature overall -0.70 -4.77 3.54 1592.24 1.00 234 126 85 22 FALSE 0.15
non-small cell lung cancer RAS_12-61 CARD11 Any mutation 363 79 Signature overall 0.18 -1.05 1.62 1460.16 1.00 620 333 49 30 FALSE 0.10
non-small cell lung cancer RAS_12-61 INPP4B Any mutation 87 15 Signature 2 0.84 -0.14 1.92 1476.83 1.00 232 79 7 8 FALSE 0.97
non-small cell lung cancer RAS_12-61 INPP4B Any mutation 277 60 Signature 4 0.21 -0.34 0.73 1291.84 1.00 398 252 35 25 FALSE 0.35
non-small cell lung cancer RAS_12-61 INPP4B Any mutation 364 75 Signature overall 0.50 -0.98 2.07 1538.26 1.00 630 331 42 33 FALSE 0.32
non-small cell lung cancer RAS_12-61 NFE2L2 Any mutation 16 15 Signature 13 -0.03 -1.32 1.13 1497.94 1.00 73 13 12 3 FALSE 0.02
non-small cell lung cancer RAS_12-61 NFE2L2 Any mutation 86 32 Signature 2 -0.61 -1.62 0.22 1584.59 1.00 218 81 27 5 FALSE 0.73
non-small cell lung cancer RAS_12-61 NFE2L2 Any mutation 276 20 Signature 4 -0.33 -1.26 0.46 1241.50 1.00 414 269 13 7 FALSE 0.34
non-small cell lung cancer RAS_12-61 NFE2L2 Any mutation 378 67 Signature overall -0.31 -1.48 0.84 1495.64 1.00 705 363 52 15 FALSE 0.22
colorectal cancer RAS_12-61 SOX9 Any mutation 175 40 Signature 15 0.37 -0.07 0.88 1326.60 1.00 196 151 16 24 FALSE 0.87
colorectal cancer RAS_12-61 SOX9 Any mutation 373 105 Signature 1A 0.30 -0.07 0.67 1532.56 1.00 430 319 51 54 FALSE 1.02
colorectal cancer RAS_12-61 SOX9 Any mutation 125 59 Signature 6 0.16 -0.36 0.60 1380.03 1.00 156 103 37 22 FALSE 0.31
colorectal cancer RAS_12-61 SOX9 Any mutation 673 204 Signature overall 0.28 -0.21 0.76 1434.59 1.00 782 573 104 100 FALSE 0.56
colorectal cancer RAS_12-61 SMAD2 Any mutation 173 16 Signature 15 0.44 -0.14 1.00 1048.97 1.01 204 165 8 8 TRUE 0.93
colorectal cancer RAS_12-61 SMAD2 Any mutation 371 33 Signature 1A 0.51 0.00 1.08 1086.25 1.00 468 349 11 22 TRUE 1.25
colorectal cancer RAS_12-61 SMAD2 Any mutation 123 17 Signature 6 0.43 -0.21 1.00 839.42 1.01 179 117 11 6 TRUE 0.83
colorectal cancer RAS_12-61 SMAD2 Any mutation 667 66 Signature overall 0.46 -0.10 0.99 912.70 1.01 851 631 30 36 TRUE 1.06
melanoma RAS_12-61 TP63 Any mutation 143 152 Signature 7 -0.59 -1.04 -0.13 1450.14 1.00 194 107 116 36 FALSE 1.94
melanoma RAS_12-61 TP63 Any mutation 143 152 Signature overall -0.57 -5.08 3.78 1418.15 1.00 194 107 116 36 FALSE 0.11
non-small cell lung cancer RAS_12-61 GLI1 Any mutation 259 44 Signature 4 0.10 -0.52 0.71 1313.07 1.00 353 240 25 19 FALSE 0.13
non-small cell lung cancer RAS_12-61 GLI1 Any mutation 259 44 Signature overall 0.05 -4.10 4.12 1418.66 1.00 353 240 25 19 FALSE 0.01
colorectal cancer RAS_12-61 ZFHX3 Any mutation 17 17 Signature 10 -0.48 -1.42 0.42 1527.11 1.00 10 11 11 6 FALSE 0.52
colorectal cancer RAS_12-61 ZFHX3 Any mutation 158 31 Signature 15 -0.91 -1.65 -0.24 1567.58 1.00 178 150 23 8 FALSE 1.97
colorectal cancer RAS_12-61 ZFHX3 Any mutation 350 80 Signature 1A -0.70 -1.18 -0.23 1507.00 1.00 403 326 56 24 FALSE 2.44
colorectal cancer RAS_12-61 ZFHX3 Any mutation 119 81 Signature 6 -0.78 -1.31 -0.26 1589.12 1.00 136 99 61 20 FALSE 2.33
melanoma RAS_12-61 ZFHX3 Any mutation 143 90 Signature 7 -0.44 -0.98 0.06 1446.53 1.00 238 120 67 23 FALSE 1.02
non-small cell lung cancer RAS_12-61 ZFHX3 Any mutation 81 18 Signature 2 -0.56 -1.61 0.41 1464.06 1.00 195 77 14 4 FALSE 0.55
non-small cell lung cancer RAS_12-61 ZFHX3 Any mutation 259 61 Signature 4 -0.43 -0.98 0.12 1491.64 1.00 338 239 41 20 FALSE 0.92
non-small cell lung cancer RAS_12-61 ZFHX3 Any mutation 139 14 Signature R2 -1.41 -2.61 -0.36 1205.11 1.00 30 133 8 6 FALSE 1.93
uterine cancer RAS_12-61 ZFHX3 Any mutation 6 21 Signature 14 0.12 -1.30 1.49 1489.53 1.00 6 2 17 4 FALSE 0.06
uterine cancer RAS_12-61 ZFHX3 Any mutation 25 13 Signature 15 0.66 -0.40 1.75 1513.77 1.00 71 19 7 6 FALSE 0.68
uterine cancer RAS_12-61 ZFHX3 Any mutation 46 56 Signature 1A 0.35 -0.28 0.99 1595.75 1.00 127 31 41 15 FALSE 0.55
uterine cancer RAS_12-61 ZFHX3 Any mutation 17 45 Signature 6 0.14 -0.84 1.04 1516.85 1.00 48 9 37 8 FALSE 0.11
colorectal cancer RAS_12-61 ZFHX3 Any mutation 644 209 Signature overall -0.70 -1.43 0.06 1630.10 1.00 727 586 151 58 FALSE 1.17
melanoma RAS_12-61 ZFHX3 Any mutation 146 129 Signature overall -1.84 -5.86 1.27 1294.48 1.00 252 123 106 23 FALSE 0.53
non-small cell lung cancer RAS_12-61 ZFHX3 Any mutation 479 93 Signature overall -0.78 -2.16 0.64 1530.11 1.00 563 449 63 30 FALSE 0.57
uterine cancer RAS_12-61 ZFHX3 Any mutation 99 184 Signature overall 0.22 -0.85 1.26 1412.98 1.00 270 63 148 36 FALSE 0.17
colorectal cancer RAS_12-61 MGA Any mutation 17 15 Signature 10 -0.35 -1.45 0.62 1548.31 1.00 11 12 10 5 FALSE 0.29
colorectal cancer RAS_12-61 MGA Any mutation 156 16 Signature 15 -0.66 -1.51 0.19 1489.00 1.00 181 151 11 5 FALSE 0.87
colorectal cancer RAS_12-61 MGA Any mutation 348 42 Signature 1A -0.27 -0.89 0.32 1348.24 1.00 420 331 25 17 FALSE 0.42
colorectal cancer RAS_12-61 MGA Any mutation 116 36 Signature 6 -0.56 -1.28 0.14 1253.77 1.00 151 106 26 10 FALSE 0.92
non-small cell lung cancer RAS_12-61 MGA Any mutation 81 28 Signature 2 -0.76 -1.80 0.17 1413.95 1.00 196 77 24 4 FALSE 0.88
non-small cell lung cancer RAS_12-61 MGA Any mutation 261 79 Signature 4 -0.08 -0.55 0.41 1542.46 1.00 332 230 48 31 FALSE 0.14
non-small cell lung cancer RAS_12-61 MGA Any mutation 139 13 Signature R2 0.07 -0.94 1.29 1400.31 1.00 36 128 2 11 FALSE 0.05
uterine cancer RAS_12-61 MGA Any mutation 7 49 Signature 10 1.26 -0.62 4.14 1381.67 1.00 20 0 42 7 FALSE 0.54
uterine cancer RAS_12-61 MGA Any mutation 41 19 Signature 1A -0.41 -1.83 0.70 1452.88 1.00 147 38 16 3 FALSE 0.28
uterine cancer RAS_12-61 MGA Any mutation 16 14 Signature 6 -1.00 -3.03 0.57 1639.44 1.00 63 15 13 1 FALSE 0.54
colorectal cancer RAS_12-61 MGA Any mutation 637 109 Signature overall -0.47 -1.37 0.40 1482.28 1.00 763 600 72 37 FALSE 0.52
non-small cell lung cancer RAS_12-61 MGA Any mutation 481 120 Signature overall -0.25 -1.51 1.14 1571.48 1.00 564 435 74 46 FALSE 0.16
uterine cancer RAS_12-61 MGA Any mutation 64 82 Signature overall -0.04 -2.05 2.05 1549.25 1.00 230 53 71 11 FALSE 0.01
colorectal cancer RAS_12-61 KMT2B Any mutation 91 18 Signature 15 -0.91 -1.83 0.02 1300.63 1.00 95 86 13 5 FALSE 1.29
colorectal cancer RAS_12-61 KMT2B Any mutation 212 64 Signature 1A -0.51 -1.04 0.00 1309.91 1.00 219 189 41 23 FALSE 1.27
colorectal cancer RAS_12-61 KMT2B Any mutation 74 86 Signature 6 -0.82 -1.44 -0.28 1359.54 1.00 68 53 65 21 FALSE 2.30
uterine cancer RAS_12-61 KMT2B Any mutation 20 15 Signature 15 0.58 -0.33 1.55 1521.48 1.00 42 13 8 7 FALSE 0.67
uterine cancer RAS_12-61 KMT2B Any mutation 40 51 Signature 1A 0.52 -0.13 1.15 1439.08 1.00 98 24 35 16 FALSE 0.95
uterine cancer RAS_12-61 KMT2B Any mutation 8 13 Signature 20 0.17 -0.98 1.22 1472.76 1.00 14 5 10 3 FALSE 0.11
uterine cancer RAS_12-61 KMT2B Any mutation 13 39 Signature 6 0.63 -0.24 1.61 1433.43 1.00 40 4 30 9 FALSE 0.78
colorectal cancer RAS_12-61 KMT2B Any mutation 377 168 Signature overall -0.76 -1.82 0.27 1417.68 1.00 382 328 119 49 FALSE 0.80
uterine cancer RAS_12-61 KMT2B Any mutation 87 152 Signature overall 0.28 -0.56 1.09 1450.59 1.00 212 50 115 37 FALSE 0.31
colorectal cancer RAS_12-61 TCF7L2 Any mutation 159 48 Signature 15 0.10 -0.37 0.61 1556.07 1.00 169 135 24 24 FALSE 0.17
colorectal cancer RAS_12-61 TCF7L2 Any mutation 354 115 Signature 1A 0.03 -0.32 0.39 1471.19 1.00 385 302 63 52 FALSE 0.06
colorectal cancer RAS_12-61 TCF7L2 Any mutation 43 12 Signature 2 0.45 -0.23 1.47 1619.12 1.00 28 32 1 11 FALSE 0.54
colorectal cancer RAS_12-61 TCF7L2 Any mutation 117 69 Signature 6 -0.27 -0.84 0.25 1307.30 1.00 131 97 49 20 FALSE 0.50
colorectal cancer RAS_12-61 TCF7L2 Any mutation 673 244 Signature overall 0.08 -0.40 0.66 1489.91 1.00 713 566 137 107 FALSE 0.12
colorectal cancer RAS_12-61 ANKRD11 Any mutation 15 12 Signature 10 -0.59 -1.71 0.48 1436.61 1.00 12 11 8 4 FALSE 0.55
colorectal cancer RAS_12-61 ANKRD11 Any mutation 152 17 Signature 15 -1.06 -2.04 -0.20 1286.48 1.00 178 148 13 4 FALSE 1.68
colorectal cancer RAS_12-61 ANKRD11 Any mutation 337 47 Signature 1A -0.92 -1.52 -0.35 1337.50 1.00 402 325 35 12 FALSE 2.61
colorectal cancer RAS_12-61 ANKRD11 Any mutation 113 57 Signature 6 -0.96 -1.54 -0.37 1402.14 1.00 139 101 45 12 FALSE 2.58
colorectal cancer RAS_12-61 ANKRD11 Any mutation 617 133 Signature overall -0.88 -1.72 -0.07 1449.59 1.00 731 585 101 32 FALSE 1.38
colorectal cancer RAS_12-61 POLD1 Any mutation 156 15 Signature 15 -1.34 -2.48 -0.37 1615.92 1.00 184 154 13 2 TRUE 1.91
colorectal cancer RAS_12-61 POLD1 Any mutation 350 43 Signature 1A -0.53 -1.16 0.07 1644.27 1.00 420 334 27 16 TRUE 1.05
colorectal cancer RAS_12-61 POLD1 Any mutation 116 44 Signature 6 -1.08 -1.85 -0.40 1496.35 1.00 148 108 36 8 TRUE 2.57
colorectal cancer RAS_12-61 POLD1 Any mutation 622 102 Signature overall -0.98 -1.94 -0.04 1485.07 1.00 752 596 76 26 TRUE 1.35
melanoma RAS_12-61 PREX2 Any mutation 102 158 Signature 7 -0.31 -0.77 0.17 1322.27 1.00 109 58 114 44 FALSE 0.72
non-small cell lung cancer RAS_12-61 PREX2 Any mutation 154 52 Signature 4 -0.37 -1.02 0.26 680.97 1.00 182 136 34 18 FALSE 0.60
melanoma RAS_12-61 PREX2 Any mutation 102 158 Signature overall -0.27 -4.52 3.62 1388.25 1.00 109 58 114 44 FALSE 0.05
non-small cell lung cancer RAS_12-61 PREX2 Any mutation 154 52 Signature overall -0.31 -4.30 3.68 1636.82 1.00 182 136 34 18 FALSE 0.06
colorectal cancer RAS_12-61 AMER1 Any mutation 173 34 Signature 15 0.72 0.29 1.18 1102.98 1.00 199 153 14 20 FALSE 2.70
colorectal cancer RAS_12-61 AMER1 Any mutation 372 61 Signature 1A 0.74 0.34 1.17 1004.23 1.00 458 332 21 40 FALSE 3.24
colorectal cancer RAS_12-61 AMER1 Any mutation 125 36 Signature 6 0.73 0.26 1.17 1062.38 1.00 173 107 18 18 FALSE 2.67
non-small cell lung cancer RAS_12-61 AMER1 Any mutation 86 11 Signature 2 1.24 0.11 2.45 1351.40 1.00 234 79 4 7 FALSE 1.40
non-small cell lung cancer RAS_12-61 AMER1 Any mutation 278 83 Signature 4 -0.02 -0.51 0.43 1409.21 1.00 389 247 52 31 FALSE 0.03
colorectal cancer RAS_12-61 AMER1 Any mutation 670 131 Signature overall 0.72 0.28 1.15 1093.34 1.00 830 592 53 78 FALSE 2.81
non-small cell lung cancer RAS_12-61 AMER1 Any mutation 364 94 Signature overall 0.61 -1.35 2.84 1568.55 1.00 623 326 56 38 FALSE 0.25
melanoma RAS_12-61 EPHA7 Any mutation 146 141 Signature 7 -0.36 -0.78 0.07 454.34 1.00 216 109 104 37 FALSE 0.95
non-small cell lung cancer RAS_12-61 EPHA7 Any mutation 50 13 Signature 3 -0.46 -1.70 0.77 1487.57 1.00 157 47 10 3 FALSE 0.33
non-small cell lung cancer RAS_12-61 EPHA7 Any mutation 257 51 Signature 4 -0.91 -1.58 -0.28 1250.35 1.00 339 246 40 11 FALSE 2.16
melanoma RAS_12-61 EPHA7 Any mutation 146 141 Signature overall -0.28 -4.47 3.84 1371.22 1.00 216 109 104 37 FALSE 0.06
non-small cell lung cancer RAS_12-61 EPHA7 Any mutation 307 64 Signature overall -0.67 -2.11 0.98 1566.74 1.00 496 293 50 14 FALSE 0.40
uterine cancer RAS_12-61 INPPL1 Any mutation 38 38 Signature 1A 0.82 0.14 1.52 1434.03 1.00 96 23 23 15 FALSE 1.62
uterine cancer RAS_12-61 INPPL1 Any mutation 8 13 Signature 20 0.64 -0.40 1.69 1234.38 1.00 12 4 9 4 FALSE 0.63
uterine cancer RAS_12-61 INPPL1 Any mutation 14 40 Signature 6 0.56 -0.29 1.42 1336.24 1.00 40 6 32 8 FALSE 0.71
uterine cancer RAS_12-61 INPPL1 Any mutation 60 91 Signature overall 0.68 -0.31 1.64 1325.75 1.00 148 33 64 27 FALSE 0.80
colorectal cancer KRAS_12-61 SPEN Any mutation 13 21 Signature 10 -1.13 -2.42 0.02 1547.21 1.00 15 10 18 3 FALSE 1.15
colorectal cancer KRAS_12-61 SPEN Any mutation 164 18 Signature 15 -1.29 -2.40 -0.30 1476.66 1.00 211 161 15 3 FALSE 1.81
colorectal cancer KRAS_12-61 SPEN Any mutation 332 38 Signature 1A -0.27 -0.94 0.39 1185.39 1.00 495 318 24 14 FALSE 0.36
colorectal cancer KRAS_12-61 SPEN Any mutation 113 61 Signature 6 -0.92 -1.60 -0.28 1410.82 1.00 165 101 49 12 FALSE 2.27
non-small cell lung cancer KRAS_12-61 SPEN Any mutation 84 39 Signature 2 -4.04 -9.81 -1.43 1274.92 1.00 228 84 39 0 FALSE 1.14
non-small cell lung cancer KRAS_12-61 SPEN Any mutation 267 24 Signature 4 -0.20 -1.14 0.70 1440.18 1.00 423 258 15 9 FALSE 0.18
uterine cancer KRAS_12-61 SPEN Any mutation 27 13 Signature 15 0.57 -0.53 1.71 1406.28 1.00 76 22 8 5 FALSE 0.51
uterine cancer KRAS_12-61 SPEN Any mutation 39 21 Signature 1A -0.18 -1.40 0.90 1591.67 1.00 165 36 18 3 FALSE 0.13
uterine cancer KRAS_12-61 SPEN Any mutation 18 21 Signature 6 0.68 -0.35 1.71 1260.71 1.00 70 12 15 6 FALSE 0.68
colorectal cancer KRAS_12-61 SPEN Any mutation 622 138 Signature overall -0.91 -2.11 0.25 1667.16 1.00 886 590 106 32 FALSE 0.93
non-small cell lung cancer KRAS_12-61 SPEN Any mutation 351 63 Signature overall -1.86 -5.74 1.43 1518.15 1.00 651 342 54 9 FALSE 0.51
uterine cancer KRAS_12-61 SPEN Any mutation 88 93 Signature overall 0.32 -0.92 1.64 1451.54 1.00 333 71 76 17 FALSE 0.21
colorectal cancer KRAS_12-61 KMT2C Any mutation 16 32 Signature 10 -0.96 -2.05 0.11 1370.17 1.01 12 10 26 6 FALSE 1.14
colorectal cancer KRAS_12-61 KMT2C Any mutation 160 22 Signature 15 -0.39 -1.24 0.43 1568.40 1.00 210 152 14 8 FALSE 0.45
colorectal cancer KRAS_12-61 KMT2C Any mutation 325 60 Signature 1A -0.11 -0.65 0.43 1508.26 1.00 474 302 37 23 FALSE 0.16
colorectal cancer KRAS_12-61 KMT2C Any mutation 107 65 Signature 6 -0.87 -1.52 -0.22 1402.53 1.00 156 94 52 13 FALSE 2.05
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 14 22 Signature 13 0.02 -0.99 1.04 1570.44 1.00 68 10 18 4 FALSE 0.01
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 85 40 Signature 2 0.16 -0.52 0.81 1508.39 1.00 214 72 27 13 FALSE 0.20
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 53 13 Signature 3 -0.65 -1.83 0.34 1358.38 1.00 178 52 12 1 FALSE 0.60
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 266 76 Signature 4 -0.45 -0.98 0.06 1662.79 1.00 387 245 55 21 FALSE 1.06
uterine cancer KRAS_12-61 KMT2C Any mutation 24 17 Signature 15 -0.53 -1.87 0.70 1657.08 1.00 72 21 14 3 FALSE 0.39
uterine cancer KRAS_12-61 KMT2C Any mutation 37 20 Signature 1A -0.86 -2.32 0.32 1254.96 1.00 151 35 18 2 FALSE 0.70
uterine cancer KRAS_12-61 KMT2C Any mutation 18 23 Signature 6 -0.60 -1.92 0.55 1456.92 1.00 61 15 20 3 FALSE 0.47
colorectal cancer KRAS_12-61 KMT2C Any mutation 608 179 Signature overall -0.58 -1.71 0.51 1328.21 1.00 852 558 129 50 FALSE 0.53
non-small cell lung cancer KRAS_12-61 KMT2C Any mutation 418 151 Signature overall -0.22 -1.03 0.55 1255.81 1.00 847 379 112 39 FALSE 0.23
uterine cancer KRAS_12-61 KMT2C Any mutation 82 118 Signature overall -0.69 -2.09 0.61 1547.10 1.00 303 72 108 10 FALSE 0.50
cancer of unknown primary KRAS_12-61 TP53 Any mutation 13 11 Signature 11 -0.03 -1.05 1.11 1406.66 1.00 7 6 4 7 TRUE 0.02
cancer of unknown primary KRAS_12-61 TP53 Any mutation 14 28 Signature 15 0.07 -0.84 1.04 1561.60 1.00 18 4 18 10 TRUE 0.06
cancer of unknown primary KRAS_12-61 TP53 Any mutation 37 66 Signature 1A -0.50 -1.18 0.20 1645.61 1.00 35 20 49 17 TRUE 0.80
cancer of unknown primary KRAS_12-61 TP53 Any mutation 7 31 Signature 2 -0.93 -2.02 0.09 1507.15 1.00 21 5 29 2 TRUE 1.06
cancer of unknown primary KRAS_12-61 TP53 Any mutation 7 18 Signature 3 -0.71 -1.73 0.28 1396.99 1.00 5 4 15 3 TRUE 0.77
cancer of unknown primary KRAS_12-61 TP53 Any mutation 23 70 Signature 4 -0.85 -1.71 -0.09 1405.68 1.00 9 10 57 13 TRUE 1.45
cancer of unknown primary KRAS_12-61 TP53 Any mutation 6 22 Signature 6 -0.27 -1.24 0.81 1482.87 1.00 7 1 17 5 TRUE 0.22
colorectal cancer KRAS_12-61 TP53 Any mutation 14 32 Signature 10 -0.94 -1.41 -0.49 1442.63 1.00 5 4 22 10 TRUE 4.33
colorectal cancer KRAS_12-61 TP53 Any mutation 25 28 Signature 11 -0.75 -1.18 -0.27 1209.69 1.00 1 8 11 17 TRUE 3.02
colorectal cancer KRAS_12-61 TP53 Any mutation 170 311 Signature 15 -0.97 -1.31 -0.64 1490.63 1.00 36 61 202 109 TRUE 8.11
colorectal cancer KRAS_12-61 TP53 Any mutation 14 36 Signature 17 -1.00 -1.49 -0.56 1454.46 1.00 5 5 27 9 TRUE 4.80
colorectal cancer KRAS_12-61 TP53 Any mutation 18 36 Signature 18 -1.01 -1.50 -0.57 1254.87 1.00 4 8 26 10 TRUE 4.86
colorectal cancer KRAS_12-61 TP53 Any mutation 21 31 Signature 19 -1.05 -1.59 -0.60 1380.81 1.00 5 12 22 9 TRUE 4.71
colorectal cancer KRAS_12-61 TP53 Any mutation 347 655 Signature 1A -0.96 -1.21 -0.70 1219.83 1.00 102 131 439 216 TRUE 13.00
colorectal cancer KRAS_12-61 TP53 Any mutation 8 15 Signature 1B -0.96 -1.49 -0.49 1223.07 1.00 4 3 10 5 TRUE 4.13
colorectal cancer KRAS_12-61 TP53 Any mutation 46 56 Signature 2 -0.98 -1.44 -0.57 1375.82 1.00 6 23 33 23 TRUE 4.96
colorectal cancer KRAS_12-61 TP53 Any mutation 13 23 Signature 20 -0.95 -1.45 -0.47 1391.40 1.00 6 5 15 8 TRUE 4.23
colorectal cancer KRAS_12-61 TP53 Any mutation 9 20 Signature 21 -1.01 -1.50 -0.54 1326.76 1.00 4 4 15 5 TRUE 4.50
colorectal cancer KRAS_12-61 TP53 Any mutation 15 35 Signature 3 -1.00 -1.48 -0.55 1103.47 1.00 1 6 26 9 TRUE 4.79
colorectal cancer KRAS_12-61 TP53 Any mutation 20 36 Signature 4 -0.92 -1.39 -0.48 1357.57 1.00 3 7 23 13 TRUE 4.28
colorectal cancer KRAS_12-61 TP53 Any mutation 125 236 Signature 6 -0.74 -1.08 -0.31 807.29 1.00 69 43 154 82 TRUE 3.71
colorectal cancer KRAS_12-61 TP53 Any mutation 15 28 Signature 7 -1.00 -1.50 -0.55 1280.95 1.00 5 7 20 8 TRUE 4.67
colorectal cancer KRAS_12-61 TP53 Any mutation 14 13 Signature 8 -0.86 -1.36 -0.38 1543.06 1.00 4 6 5 8 TRUE 3.29
colorectal cancer KRAS_12-61 TP53 Any mutation 17 16 Signature R2 -0.82 -1.29 -0.32 1286.09 1.00 0 7 6 10 TRUE 3.22
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 22 12 Signature 11 -1.48 -2.32 -0.66 1369.87 1.00 13 19 9 3 TRUE 3.28
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 16 79 Signature 13 -0.94 -1.67 -0.21 1552.08 1.00 26 5 68 11 TRUE 1.97
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 21 36 Signature 14 -1.12 -1.88 -0.39 1514.15 1.00 12 12 27 9 TRUE 2.49
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 31 87 Signature 15 -1.21 -1.85 -0.57 1501.65 1.00 35 18 74 13 TRUE 3.66
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 11 39 Signature 16 -0.91 -1.72 -0.07 1472.19 1.00 20 4 32 7 TRUE 1.61
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 19 29 Signature 17 -1.59 -2.37 -0.80 1264.86 1.00 5 14 24 5 TRUE 4.10
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 68 92 Signature 18 -1.06 -1.61 -0.54 1477.68 1.00 26 38 62 30 TRUE 4.09
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 16 31 Signature 19 -1.21 -2.00 -0.46 1419.19 1.00 24 11 26 5 TRUE 2.65
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 49 149 Signature 1A -1.01 -1.58 -0.46 1304.59 1.00 94 30 130 19 TRUE 3.50
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 86 223 Signature 2 -0.82 -1.28 -0.36 1391.65 1.00 83 41 178 45 TRUE 3.28
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 15 46 Signature 20 -1.42 -2.23 -0.64 1463.89 1.00 21 10 41 5 TRUE 3.41
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 11 37 Signature 21 -1.84 -2.74 -0.98 1492.48 1.00 19 10 36 1 TRUE 4.28
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 56 161 Signature 3 -1.15 -1.63 -0.61 1620.70 1.00 63 32 137 24 TRUE 5.08
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 270 522 Signature 4 -1.74 -2.08 -1.42 1073.10 1.00 76 150 402 120 TRUE 25.20
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 13 36 Signature 6 -1.26 -2.05 -0.52 1485.73 1.00 10 7 30 6 TRUE 2.88
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 26 71 Signature 7 -1.02 -1.66 -0.40 1524.47 1.00 28 13 58 13 TRUE 2.77
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 29 35 Signature 8 -1.04 -1.74 -0.38 1390.77 1.00 11 17 23 12 TRUE 2.51
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 155 85 Signature R2 -1.47 -2.00 -0.98 1498.35 1.00 12 109 39 46 TRUE 7.49
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 7 15 Signature R3 -1.58 -2.53 -0.69 1432.92 1.00 11 6 14 1 TRUE 3.12
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 21 57 Signature U1 -1.49 -2.25 -0.75 1349.54 1.00 40 16 52 5 TRUE 3.95
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 12 32 Signature U2 -1.50 -2.34 -0.70 1541.50 1.00 7 8 28 4 TRUE 3.63
pancreatic cancer KRAS_12-61 TP53 Any mutation 116 94 Signature 11 2.46 1.91 2.98 1047.16 1.00 5 26 4 90 TRUE 30.91
pancreatic cancer KRAS_12-61 TP53 Any mutation 113 98 Signature 15 2.31 1.74 2.82 1244.04 1.00 10 25 10 88 TRUE 30.91
pancreatic cancer KRAS_12-61 TP53 Any mutation 24 19 Signature 16 2.42 1.79 3.04 1056.61 1.00 7 5 0 19 TRUE 14.02
pancreatic cancer KRAS_12-61 TP53 Any mutation 52 41 Signature 17 2.54 1.96 3.20 1228.20 1.00 3 11 0 41 TRUE 15.35
pancreatic cancer KRAS_12-61 TP53 Any mutation 15 14 Signature 18 2.31 1.72 2.93 1215.11 1.00 6 3 2 12 TRUE 13.01
pancreatic cancer KRAS_12-61 TP53 Any mutation 15 16 Signature 19 2.31 1.69 2.90 1328.17 1.00 8 2 3 13 TRUE 12.89
pancreatic cancer KRAS_12-61 TP53 Any mutation 218 172 Signature 1A 2.28 1.76 2.76 1063.43 1.00 24 57 11 161 TRUE 30.91
pancreatic cancer KRAS_12-61 TP53 Any mutation 16 12 Signature 1B 2.31 1.67 2.91 1464.03 1.00 4 5 1 11 TRUE 12.65
pancreatic cancer KRAS_12-61 TP53 Any mutation 33 29 Signature 2 2.40 1.86 3.06 1114.39 1.00 11 6 2 27 TRUE 14.75
pancreatic cancer KRAS_12-61 TP53 Any mutation 25 21 Signature 21 2.41 1.77 3.01 1190.39 1.00 6 5 1 20 TRUE 14.10
pancreatic cancer KRAS_12-61 TP53 Any mutation 80 66 Signature 3 2.39 1.84 2.96 909.93 1.00 14 18 4 62 TRUE 30.91
pancreatic cancer KRAS_12-61 TP53 Any mutation 64 58 Signature 4 2.61 2.04 3.25 1246.48 1.00 7 8 2 56 TRUE 30.91
pancreatic cancer KRAS_12-61 TP53 Any mutation 61 53 Signature 6 2.43 1.88 3.01 1336.78 1.00 9 12 4 49 TRUE 30.91
pancreatic cancer KRAS_12-61 TP53 Any mutation 26 25 Signature 7 2.51 1.92 3.24 1050.21 1.00 8 2 1 24 TRUE 13.56
pancreatic cancer KRAS_12-61 TP53 Any mutation 49 37 Signature 8 2.49 1.94 3.09 1126.76 1.00 3 12 0 37 TRUE 30.91
pancreatic cancer KRAS_12-61 TP53 Any mutation 23 19 Signature R3 2.47 1.85 3.13 1092.48 1.00 1 5 1 18 TRUE 13.32
pancreatic cancer KRAS_12-61 TP53 Any mutation 12 11 Signature U1 2.36 1.74 3.04 1134.88 1.00 10 1 0 11 TRUE 12.82
uterine cancer KRAS_12-61 TP53 Any mutation 26 53 Signature 15 -1.68 -2.53 -0.91 1390.06 1.00 34 21 48 5 TRUE 4.19
uterine cancer KRAS_12-61 TP53 Any mutation 40 113 Signature 1A -1.26 -1.91 -0.60 1555.87 1.00 89 28 101 12 TRUE 3.74
uterine cancer KRAS_12-61 TP53 Any mutation 6 19 Signature 2 -1.92 -3.17 -0.94 1513.96 1.00 23 6 19 0 TRUE 3.02
uterine cancer KRAS_12-61 TP53 Any mutation 9 19 Signature 20 -1.41 -2.40 -0.36 1463.16 1.00 19 6 16 3 TRUE 2.27
uterine cancer KRAS_12-61 TP53 Any mutation 10 30 Signature 3 -1.59 -2.62 -0.69 1676.65 1.00 10 7 27 3 TRUE 3.02
uterine cancer KRAS_12-61 TP53 Any mutation 17 45 Signature 6 -1.94 -3.04 -1.05 1385.48 1.00 46 16 44 1 TRUE 3.91
cancer of unknown primary KRAS_12-61 TP53 Any mutation 110 287 Signature overall -0.53 -1.18 0.18 1533.18 1.00 122 52 229 58 TRUE 0.92
colorectal cancer KRAS_12-61 TP53 Any mutation 891 1607 Signature overall -0.94 -1.21 -0.68 1204.82 1.00 260 340 1056 551 TRUE 12.01
non-small cell lung cancer KRAS_12-61 TP53 Any mutation 964 1927 Signature overall -1.31 -1.62 -0.99 1431.53 1.00 654 576 1539 388 TRUE 15.64
pancreatic cancer KRAS_12-61 TP53 Any mutation 942 785 Signature overall 2.41 2.02 2.82 860.75 1.00 136 203 46 739 TRUE 30.91
uterine cancer KRAS_12-61 TP53 Any mutation 112 356 Signature overall -1.72 -2.46 -1.07 1507.88 1.00 270 88 332 24 TRUE 5.89
colorectal cancer KRAS_12-61 ATRX Any mutation 14 19 Signature 10 -1.03 -2.42 0.14 1380.88 1.00 15 11 16 3 TRUE 0.97
colorectal cancer KRAS_12-61 ATRX Any mutation 334 46 Signature 1A -0.32 -0.94 0.27 1375.37 1.00 487 318 30 16 TRUE 0.51
colorectal cancer KRAS_12-61 ATRX Any mutation 111 29 Signature 6 -0.84 -1.81 0.04 1401.64 1.00 180 105 23 6 TRUE 1.15
non-small cell lung cancer KRAS_12-61 ATRX Any mutation 67 12 Signature 18 0.06 -0.68 0.84 1417.16 1.00 78 61 6 6 TRUE 0.06
non-small cell lung cancer KRAS_12-61 ATRX Any mutation 84 28 Signature 2 0.04 -0.61 0.68 1366.68 1.00 223 76 20 8 TRUE 0.04
non-small cell lung cancer KRAS_12-61 ATRX Any mutation 270 88 Signature 4 -0.01 -0.44 0.41 1647.39 1.00 392 238 56 32 TRUE 0.02
uterine cancer KRAS_12-61 ATRX Any mutation 6 11 Signature 14 -0.64 -2.55 1.12 1456.53 1.00 10 4 9 2 TRUE 0.31
uterine cancer KRAS_12-61 ATRX Any mutation 39 12 Signature 1A -0.48 -2.17 0.98 1487.06 1.00 170 37 10 2 TRUE 0.26
uterine cancer KRAS_12-61 ATRX Any mutation 17 13 Signature 6 -2.38 -5.86 -0.11 1317.34 1.00 71 17 13 0 TRUE 0.93
colorectal cancer KRAS_12-61 ATRX Any mutation 459 94 Signature overall -0.72 -2.17 0.75 1280.19 1.00 682 434 69 25 TRUE 0.51
non-small cell lung cancer KRAS_12-61 ATRX Any mutation 421 128 Signature overall 0.03 -0.66 0.67 1695.58 1.00 693 375 82 46 TRUE 0.03
uterine cancer KRAS_12-61 ATRX Any mutation 65 123 Signature overall -0.88 -3.03 1.20 1533.22 1.00 266 58 116 7 TRUE 0.38
colorectal cancer KRAS_12-61 ATR Any mutation 14 28 Signature 10 -1.14 -2.32 -0.03 1462.29 1.00 14 10 24 4 FALSE 1.25
colorectal cancer KRAS_12-61 ATR Any mutation 165 12 Signature 15 -0.04 -1.09 1.06 1400.82 1.00 217 159 6 6 FALSE 0.02
colorectal cancer KRAS_12-61 ATR Any mutation 331 32 Signature 1A -0.74 -1.55 -0.02 1415.44 1.00 491 323 24 8 FALSE 1.23
colorectal cancer KRAS_12-61 ATR Any mutation 113 28 Signature 6 -0.78 -1.75 0.08 1598.13 1.00 185 107 22 6 FALSE 1.04
non-small cell lung cancer KRAS_12-61 ATR Any mutation 14 11 Signature 13 -0.12 -1.38 1.07 1553.09 1.00 75 12 9 2 FALSE 0.07
non-small cell lung cancer KRAS_12-61 ATR Any mutation 84 16 Signature 2 -0.23 -1.16 0.73 1414.05 1.00 228 80 12 4 FALSE 0.20
non-small cell lung cancer KRAS_12-61 ATR Any mutation 267 60 Signature 4 -0.41 -0.98 0.14 1315.76 1.00 394 250 43 17 FALSE 0.78
colorectal cancer KRAS_12-61 ATR Any mutation 623 100 Signature overall -0.68 -2.00 0.62 1379.38 1.00 907 599 76 24 FALSE 0.51
non-small cell lung cancer KRAS_12-61 ATR Any mutation 365 87 Signature overall -0.25 -1.21 0.85 1484.74 1.00 697 342 64 23 FALSE 0.20
non-small cell lung cancer KRAS_12-61 PDGFRA Any mutation 84 20 Signature 2 -0.18 -1.04 0.66 1371.00 1.00 225 79 15 5 TRUE 0.17
non-small cell lung cancer KRAS_12-61 PDGFRA Any mutation 268 70 Signature 4 -0.21 -0.69 0.26 1515.38 1.00 393 245 47 23 TRUE 0.40
non-small cell lung cancer KRAS_12-61 PDGFRA Any mutation 352 90 Signature overall -0.19 -1.29 0.93 1361.38 1.00 618 324 62 28 TRUE 0.13
colorectal cancer KRAS_12-61 FBXW7 Any mutation 12 17 Signature 10 -0.16 -1.39 0.72 1376.32 1.00 11 9 14 3 TRUE 0.11
colorectal cancer KRAS_12-61 FBXW7 Any mutation 167 48 Signature 15 0.25 -0.28 0.79 1558.04 1.00 201 143 24 24 TRUE 0.44
colorectal cancer KRAS_12-61 FBXW7 Any mutation 345 144 Signature 1A 0.47 0.13 0.80 1401.21 1.00 450 272 71 73 TRUE 2.20
colorectal cancer KRAS_12-61 FBXW7 Any mutation 115 78 Signature 6 0.38 -0.11 0.85 1504.68 1.00 160 81 44 34 TRUE 0.93
uterine cancer KRAS_12-61 FBXW7 Any mutation 26 17 Signature 15 -0.26 -1.40 0.84 1462.43 1.00 69 23 14 3 TRUE 0.19
uterine cancer KRAS_12-61 FBXW7 Any mutation 39 35 Signature 1A -0.05 -0.97 0.78 1517.43 1.00 152 33 29 6 TRUE 0.04
uterine cancer KRAS_12-61 FBXW7 Any mutation 17 18 Signature 6 0.50 -0.61 1.60 1568.93 1.00 67 12 13 5 TRUE 0.43
colorectal cancer KRAS_12-61 FBXW7 Any mutation 639 287 Signature overall 0.24 -0.48 0.89 1396.66 1.00 822 505 153 134 TRUE 0.31
uterine cancer KRAS_12-61 FBXW7 Any mutation 86 101 Signature overall 0.19 -0.92 1.51 1511.06 1.00 306 68 83 18 TRUE 0.13
uterine cancer KRAS_12-61 NSD1 Any mutation 41 22 Signature 1A 0.53 -0.47 1.46 1359.46 1.00 166 35 16 6 FALSE 0.55
uterine cancer KRAS_12-61 NSD1 Any mutation 20 29 Signature 6 0.75 -0.24 1.76 1445.56 1.00 66 12 21 8 FALSE 0.91
uterine cancer KRAS_12-61 NSD1 Any mutation 64 88 Signature overall 0.73 -1.04 2.70 1183.90 1.00 249 47 71 17 FALSE 0.33
colorectal cancer KRAS_12-61 FLT4 Any mutation 12 14 Signature 10 -1.33 -2.90 -0.04 1474.87 1.00 16 11 13 1 TRUE 1.17
colorectal cancer KRAS_12-61 FLT4 Any mutation 165 14 Signature 15 -0.41 -1.39 0.56 1502.60 1.00 213 159 8 6 TRUE 0.40
colorectal cancer KRAS_12-61 FLT4 Any mutation 334 54 Signature 1A -0.38 -0.94 0.20 1451.30 1.00 479 316 36 18 TRUE 0.72
colorectal cancer KRAS_12-61 FLT4 Any mutation 111 51 Signature 6 -1.02 -1.78 -0.33 1566.03 1.00 164 102 42 9 TRUE 2.27
non-small cell lung cancer KRAS_12-61 FLT4 Any mutation 84 11 Signature 2 -0.86 -2.37 0.32 1295.73 1.00 230 83 10 1 TRUE 0.67
non-small cell lung cancer KRAS_12-61 FLT4 Any mutation 266 36 Signature 4 -0.42 -1.15 0.28 1607.22 1.00 413 255 25 11 TRUE 0.59
colorectal cancer KRAS_12-61 FLT4 Any mutation 622 133 Signature overall -0.79 -1.95 0.26 1451.02 1.00 872 588 99 34 TRUE 0.82
non-small cell lung cancer KRAS_12-61 FLT4 Any mutation 350 47 Signature overall -0.62 -2.19 0.73 1493.71 1.00 643 338 35 12 TRUE 0.41
colorectal cancer KRAS_12-61 PTPRD Any mutation 13 19 Signature 10 -0.87 -2.22 0.30 1403.81 1.00 16 10 16 3 FALSE 0.77
colorectal cancer KRAS_12-61 PTPRD Any mutation 164 14 Signature 15 -0.51 -1.55 0.46 1393.38 1.00 214 159 9 5 FALSE 0.49
colorectal cancer KRAS_12-61 PTPRD Any mutation 331 31 Signature 1A -0.43 -1.13 0.33 1437.14 1.00 496 321 21 10 FALSE 0.62
colorectal cancer KRAS_12-61 PTPRD Any mutation 111 31 Signature 6 -0.88 -1.83 -0.08 1356.47 1.00 180 105 25 6 FALSE 1.34
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 69 22 Signature 18 0.70 -0.11 1.50 1381.97 1.00 76 55 8 14 FALSE 1.10
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 47 12 Signature 1A 0.21 -0.86 1.18 1447.63 1.00 210 44 9 3 FALSE 0.16
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 84 33 Signature 2 0.32 -0.41 0.98 1472.51 1.00 219 73 22 11 FALSE 0.45
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 15 12 Signature 20 -0.05 -1.26 1.07 1529.03 1.00 54 13 10 2 FALSE 0.03
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 54 18 Signature 3 0.75 -0.15 1.63 1361.64 1.00 179 46 10 8 FALSE 1.02
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 283 195 Signature 4 -0.05 -0.39 0.29 1395.63 1.00 340 212 124 71 FALSE 0.10
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 155 18 Signature R2 -0.45 -1.29 0.36 1418.57 1.00 38 144 7 11 FALSE 0.51
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 12 11 Signature U2 0.17 -0.99 1.33 1482.47 1.00 26 9 8 3 FALSE 0.12
colorectal cancer KRAS_12-61 PTPRD Any mutation 619 95 Signature overall -0.64 -1.73 0.43 1457.28 1.00 906 595 71 24 FALSE 0.62
non-small cell lung cancer KRAS_12-61 PTPRD Any mutation 719 321 Signature overall 0.20 -0.48 0.88 1459.92 1.00 1142 596 198 123 FALSE 0.25
non-small cell lung cancer KRAS_12-61 PIK3C2G Any mutation 84 17 Signature 2 -0.94 -2.16 0.12 1169.64 1.00 224 82 15 2 FALSE 0.98
non-small cell lung cancer KRAS_12-61 PIK3C2G Any mutation 266 57 Signature 4 -0.70 -1.35 -0.06 900.96 1.00 397 252 43 14 FALSE 1.59
non-small cell lung cancer KRAS_12-61 PIK3C2G Any mutation 350 74 Signature overall -0.82 -2.14 0.26 1480.84 1.00 621 334 58 16 FALSE 0.71
colorectal cancer KRAS_12-61 CREBBP Any mutation 12 15 Signature 10 -1.04 -2.41 0.14 1350.91 1.00 16 10 13 2 TRUE 0.97
colorectal cancer KRAS_12-61 CREBBP Any mutation 164 27 Signature 15 -0.84 -1.66 -0.05 1556.29 1.00 206 157 20 7 TRUE 1.39
colorectal cancer KRAS_12-61 CREBBP Any mutation 334 45 Signature 1A 0.13 -0.46 0.74 1400.36 1.00 492 313 24 21 TRUE 0.17
colorectal cancer KRAS_12-61 CREBBP Any mutation 117 80 Signature 6 -1.20 -1.85 -0.61 1542.58 1.00 151 104 67 13 TRUE 3.77
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 47 12 Signature 1A 0.11 -0.81 0.97 1538.97 1.00 210 44 9 3 TRUE 0.09
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 84 15 Signature 2 -0.21 -1.15 0.56 1526.91 1.00 227 82 13 2 TRUE 0.20
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 54 11 Signature 3 0.19 -0.68 1.07 1583.10 1.00 182 50 7 4 TRUE 0.17
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 266 44 Signature 4 0.08 -0.48 0.63 1590.95 1.00 414 249 27 17 TRUE 0.11
colorectal cancer KRAS_12-61 CREBBP Any mutation 627 167 Signature overall -0.72 -1.77 0.30 1594.78 1.00 865 584 124 43 TRUE 0.77
non-small cell lung cancer KRAS_12-61 CREBBP Any mutation 451 82 Signature overall 0.05 -0.66 0.73 1627.33 1.00 1033 425 56 26 TRUE 0.05
colorectal cancer KRAS_12-61 AXIN2 Any mutation 164 17 Signature 15 -0.51 -1.41 0.34 1696.09 1.00 212 158 11 6 TRUE 0.60
colorectal cancer KRAS_12-61 AXIN2 Any mutation 331 36 Signature 1A -0.24 -0.88 0.44 1416.25 1.00 496 317 22 14 TRUE 0.32
colorectal cancer KRAS_12-61 AXIN2 Any mutation 112 40 Signature 6 -1.09 -2.06 -0.31 1536.20 1.00 174 107 35 5 TRUE 1.89
colorectal cancer KRAS_12-61 AXIN2 Any mutation 607 93 Signature overall -0.60 -1.54 0.37 1438.44 1.00 882 582 68 25 TRUE 0.67
non-small cell lung cancer KRAS_12-61 DOT1L Any mutation 84 16 Signature 2 -0.38 -1.38 0.52 1543.81 1.00 227 81 13 3 FALSE 0.36
non-small cell lung cancer KRAS_12-61 DOT1L Any mutation 266 38 Signature 4 -0.22 -0.89 0.39 1459.38 1.00 412 253 25 13 FALSE 0.30
non-small cell lung cancer KRAS_12-61 DOT1L Any mutation 350 54 Signature overall -0.31 -1.48 0.70 1518.64 1.00 639 334 38 16 FALSE 0.24
colorectal cancer KRAS_12-61 PTPRS Any mutation 13 16 Signature 10 -0.94 -2.40 0.08 1371.02 1.00 13 11 14 2 FALSE 0.88
colorectal cancer KRAS_12-61 PTPRS Any mutation 162 38 Signature 15 -0.18 -0.81 0.45 1450.28 1.00 198 146 22 16 FALSE 0.24
colorectal cancer KRAS_12-61 PTPRS Any mutation 323 95 Signature 1A 0.10 -0.32 0.54 1497.97 1.00 457 282 54 41 FALSE 0.20
colorectal cancer KRAS_12-61 PTPRS Any mutation 112 83 Signature 6 -0.90 -1.50 -0.33 1595.76 1.00 149 96 67 16 FALSE 2.56
colorectal cancer KRAS_12-61 PTPRS Any mutation 610 232 Signature overall -0.48 -1.44 0.33 1341.29 1.00 817 535 157 75 FALSE 0.56
colorectal cancer KRAS_12-61 SMARCA4 Any mutation 165 22 Signature 15 -0.37 -1.10 0.42 1514.28 1.00 213 156 13 9 FALSE 0.47
colorectal cancer KRAS_12-61 SMARCA4 Any mutation 336 74 Signature 1A -0.36 -0.86 0.14 1512.68 1.00 474 311 49 25 FALSE 0.81
colorectal cancer KRAS_12-61 SMARCA4 Any mutation 112 52 Signature 6 -1.21 -2.05 -0.50 1360.95 1.00 168 106 46 6 FALSE 2.54
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 14 11 Signature 13 0.10 -1.02 1.22 1582.72 1.00 75 12 9 2 FALSE 0.06
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 67 14 Signature 18 0.73 -0.14 1.64 1378.08 1.00 80 57 4 10 FALSE 0.97
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 47 17 Signature 1A -0.03 -1.02 0.94 1561.82 1.00 207 44 14 3 FALSE 0.02
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 86 33 Signature 2 -0.07 -0.84 0.62 1603.36 1.00 220 78 25 8 FALSE 0.07
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 54 16 Signature 3 0.63 -0.27 1.54 1534.69 1.00 181 47 9 7 FALSE 0.78
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 267 104 Signature 4 -0.29 -0.74 0.12 1413.11 1.00 370 235 72 32 FALSE 0.74
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 24 15 Signature 7 -0.06 -1.13 0.90 1636.45 1.00 72 21 12 3 FALSE 0.04
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 154 15 Signature R2 -0.27 -1.11 0.60 1590.94 1.00 39 144 5 10 FALSE 0.27
uterine cancer KRAS_12-61 SMARCA4 Any mutation 28 14 Signature 15 0.15 -0.86 1.19 1437.09 1.00 76 23 9 5 FALSE 0.11
uterine cancer KRAS_12-61 SMARCA4 Any mutation 39 21 Signature 1A -0.49 -1.68 0.50 1529.75 1.00 163 37 19 2 FALSE 0.44
uterine cancer KRAS_12-61 SMARCA4 Any mutation 19 30 Signature 6 -0.27 -1.37 0.67 1444.30 1.00 66 15 26 4 FALSE 0.22
colorectal cancer KRAS_12-61 SMARCA4 Any mutation 613 148 Signature overall -0.64 -1.55 0.21 1471.78 1.00 855 573 108 40 FALSE 0.87
non-small cell lung cancer KRAS_12-61 SMARCA4 Any mutation 713 225 Signature overall 0.09 -0.57 0.76 1546.36 1.00 1244 638 150 75 FALSE 0.10
uterine cancer KRAS_12-61 SMARCA4 Any mutation 88 76 Signature overall -0.20 -1.28 0.80 1532.82 1.00 333 76 64 12 FALSE 0.16
colorectal cancer KRAS_12-61 PTPRT Any mutation 16 23 Signature 10 -0.76 -1.91 0.24 1598.08 1.00 13 11 18 5 FALSE 0.79
colorectal cancer KRAS_12-61 PTPRT Any mutation 164 25 Signature 15 -1.28 -2.24 -0.42 1633.53 1.00 201 160 21 4 FALSE 2.25
colorectal cancer KRAS_12-61 PTPRT Any mutation 332 66 Signature 1A -0.04 -0.57 0.46 1662.77 1.00 476 305 39 27 FALSE 0.05
colorectal cancer KRAS_12-61 PTPRT Any mutation 112 43 Signature 6 -0.59 -1.32 0.05 1535.38 1.00 170 101 32 11 FALSE 1.05
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 14 11 Signature 13 0.26 -1.14 1.51 1383.92 1.00 78 11 8 3 FALSE 0.15
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 66 17 Signature 18 -0.62 -1.59 0.31 1543.38 1.00 73 61 12 5 FALSE 0.69
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 47 11 Signature 1A -1.21 -2.98 0.15 1443.55 1.00 211 47 11 0 FALSE 0.88
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 85 30 Signature 2 0.75 -0.01 1.46 1616.51 1.00 225 71 16 14 FALSE 1.34
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 54 19 Signature 3 -0.51 -1.60 0.45 1437.23 1.00 175 51 16 3 FALSE 0.46
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 270 179 Signature 4 -0.91 -1.29 -0.52 1560.44 1.00 334 232 141 38 FALSE 5.35
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 156 23 Signature R2 -0.45 -1.28 0.40 1572.49 1.00 39 141 8 15 FALSE 0.54
colorectal cancer KRAS_12-61 PTPRT Any mutation 624 157 Signature overall -0.66 -1.66 0.28 1358.99 1.00 860 577 110 47 FALSE 0.74
non-small cell lung cancer KRAS_12-61 PTPRT Any mutation 692 290 Signature overall -0.40 -1.20 0.39 1496.02 1.00 1135 614 212 78 FALSE 0.47
non-small cell lung cancer KRAS_12-61 HGF Any mutation 84 20 Signature 2 0.45 -0.44 1.42 1488.76 1.00 228 76 12 8 FALSE 0.48
non-small cell lung cancer KRAS_12-61 HGF Any mutation 266 89 Signature 4 -0.31 -0.78 0.13 1593.53 1.00 384 238 61 28 FALSE 0.73
non-small cell lung cancer KRAS_12-61 HGF Any mutation 155 12 Signature R2 -1.00 -2.16 0.11 1467.85 1.00 39 149 6 6 FALSE 1.07
non-small cell lung cancer KRAS_12-61 HGF Any mutation 505 121 Signature overall -0.31 -1.90 1.17 1305.88 1.00 651 463 79 42 FALSE 0.17
colorectal cancer KRAS_12-61 PIK3CA Any mutation 13 23 Signature 10 0.24 -0.58 1.02 1336.14 1.00 13 7 17 6 TRUE 0.26
colorectal cancer KRAS_12-61 PIK3CA Any mutation 164 63 Signature 15 0.26 -0.18 0.74 1457.30 1.00 193 134 33 30 TRUE 0.56
colorectal cancer KRAS_12-61 PIK3CA Any mutation 18 19 Signature 18 0.37 -0.43 1.13 1417.64 1.00 18 11 12 7 TRUE 0.45
colorectal cancer KRAS_12-61 PIK3CA Any mutation 341 191 Signature 1A 0.54 0.24 0.85 1433.63 1.00 428 245 95 96 TRUE 3.35
colorectal cancer KRAS_12-61 PIK3CA Any mutation 48 43 Signature 2 1.19 0.57 1.87 1425.82 1.00 26 16 11 32 TRUE 3.46
colorectal cancer KRAS_12-61 PIK3CA Any mutation 119 95 Signature 6 0.51 0.07 0.96 1289.58 1.00 155 76 52 43 TRUE 1.62
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 15 13 Signature 13 0.97 -0.17 2.16 1451.29 1.00 77 9 7 6 TRUE 1.01
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 47 13 Signature 1A 0.04 -1.10 1.09 1495.43 1.00 210 44 10 3 TRUE 0.02
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 85 82 Signature 2 0.17 -0.39 0.68 1545.03 1.00 186 62 59 23 TRUE 0.26
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 15 16 Signature 20 -0.04 -1.22 1.00 1540.14 1.00 49 12 13 3 TRUE 0.02
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 54 15 Signature 3 -1.03 -2.57 0.14 1478.90 1.00 174 54 15 0 TRUE 0.89
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 266 38 Signature 4 -0.40 -1.08 0.21 1593.98 1.00 410 255 27 11 TRUE 0.67
uterine cancer KRAS_12-61 PIK3CA Any mutation 29 50 Signature 15 -0.03 -0.81 0.70 1621.69 1.00 50 18 39 11 TRUE 0.03
uterine cancer KRAS_12-61 PIK3CA Any mutation 47 138 Signature 1A 0.84 0.24 1.48 1298.30 1.00 101 13 104 34 TRUE 2.09
uterine cancer KRAS_12-61 PIK3CA Any mutation 6 30 Signature 2 0.00 -1.16 1.12 1472.70 1.00 17 3 27 3 TRUE 0.00
uterine cancer KRAS_12-61 PIK3CA Any mutation 9 25 Signature 20 -0.01 -1.10 1.01 1470.13 1.00 14 5 21 4 TRUE 0.01
uterine cancer KRAS_12-61 PIK3CA Any mutation 11 21 Signature 3 1.19 0.10 2.35 1626.50 1.00 24 2 12 9 TRUE 1.44
uterine cancer KRAS_12-61 PIK3CA Any mutation 24 85 Signature 6 0.64 -0.17 1.50 1018.49 1.00 34 5 66 19 TRUE 0.89
colorectal cancer KRAS_12-61 PIK3CA Any mutation 703 434 Signature overall 0.52 0.04 1.00 1279.33 1.00 833 489 220 214 TRUE 1.45
non-small cell lung cancer KRAS_12-61 PIK3CA Any mutation 482 177 Signature overall -0.05 -0.85 0.75 1386.01 1.00 1106 436 131 46 TRUE 0.05
uterine cancer KRAS_12-61 PIK3CA Any mutation 134 459 Signature overall 0.27 -0.42 0.97 1426.47 1.00 308 48 373 86 TRUE 0.35
colorectal cancer KRAS_12-61 ALK Any mutation 13 13 Signature 10 -0.38 -1.75 0.85 1530.69 1.00 16 10 10 3 TRUE 0.25
colorectal cancer KRAS_12-61 ALK Any mutation 164 16 Signature 15 0.64 -0.30 1.62 1357.36 1.00 216 153 5 11 TRUE 0.72
colorectal cancer KRAS_12-61 ALK Any mutation 333 35 Signature 1A -0.06 -0.71 0.58 1568.56 1.00 494 319 21 14 TRUE 0.07
colorectal cancer KRAS_12-61 ALK Any mutation 111 37 Signature 6 -0.94 -1.86 -0.19 1280.76 1.00 176 105 31 6 TRUE 1.52
non-small cell lung cancer KRAS_12-61 ALK Any mutation 84 24 Signature 2 0.13 -0.60 0.95 1234.25 1.00 226 76 16 8 TRUE 0.12
non-small cell lung cancer KRAS_12-61 ALK Any mutation 266 72 Signature 4 -0.14 -0.59 0.34 1428.50 1.00 393 242 48 24 TRUE 0.25
colorectal cancer KRAS_12-61 ALK Any mutation 621 101 Signature overall -0.19 -1.29 0.94 1418.45 1.00 902 587 67 34 TRUE 0.13
non-small cell lung cancer KRAS_12-61 ALK Any mutation 350 96 Signature overall -0.01 -1.25 1.18 1352.88 1.00 619 318 64 32 TRUE 0.01
colorectal cancer KRAS_12-61 RNF43 Any mutation 167 31 Signature 15 -0.88 -1.67 -0.15 1382.79 1.00 205 159 23 8 TRUE 1.65
colorectal cancer KRAS_12-61 RNF43 Any mutation 339 93 Signature 1A -0.41 -0.85 0.04 1505.62 1.00 472 309 63 30 TRUE 1.13
colorectal cancer KRAS_12-61 RNF43 Any mutation 114 102 Signature 6 -1.22 -1.88 -0.68 1469.56 1.00 140 98 86 16 TRUE 4.23
colorectal cancer KRAS_12-61 RNF43 Any mutation 620 226 Signature overall -0.84 -1.77 0.08 1493.29 1.00 817 566 172 54 TRUE 1.02
colorectal cancer KRAS_12-61 PTEN Any mutation 13 13 Signature 10 -0.36 -1.57 0.69 1447.64 1.00 15 10 10 3 TRUE 0.27
colorectal cancer KRAS_12-61 PTEN Any mutation 164 22 Signature 15 0.29 -0.45 1.14 1549.60 1.00 213 151 9 13 TRUE 0.33
colorectal cancer KRAS_12-61 PTEN Any mutation 335 64 Signature 1A -0.18 -0.70 0.30 1314.46 1.00 485 312 41 23 TRUE 0.33
colorectal cancer KRAS_12-61 PTEN Any mutation 113 57 Signature 6 -0.66 -1.32 -0.04 1490.42 1.00 173 101 45 12 TRUE 1.39
non-small cell lung cancer KRAS_12-61 PTEN Any mutation 84 27 Signature 2 -0.74 -1.77 -0.01 18.16 1.07 220 80 23 4 TRUE 1.07
non-small cell lung cancer KRAS_12-61 PTEN Any mutation 266 27 Signature 4 -0.75 -1.65 -0.17 7.43 1.13 416 260 21 6 TRUE 1.28
uterine cancer KRAS_12-61 PTEN Any mutation 8 14 Signature 14 1.11 0.10 2.12 1389.41 1.00 10 2 8 6 TRUE 1.51
uterine cancer KRAS_12-61 PTEN Any mutation 37 61 Signature 15 1.13 0.46 1.77 1533.86 1.00 57 12 36 25 TRUE 3.09
uterine cancer KRAS_12-61 PTEN Any mutation 55 155 Signature 1A 1.02 0.45 1.61 1437.32 1.00 114 14 114 41 TRUE 3.35
uterine cancer KRAS_12-61 PTEN Any mutation 6 15 Signature 1B 1.25 0.20 2.31 1541.30 1.00 8 0 9 6 TRUE 1.70
uterine cancer KRAS_12-61 PTEN Any mutation 8 26 Signature 2 0.51 -0.44 1.33 1577.24 1.00 24 4 22 4 TRUE 0.56
uterine cancer KRAS_12-61 PTEN Any mutation 12 28 Signature 20 1.18 0.33 2.11 1324.56 1.00 19 2 18 10 TRUE 2.01
uterine cancer KRAS_12-61 PTEN Any mutation 13 17 Signature 3 1.31 0.42 2.26 1354.66 1.00 30 4 8 9 TRUE 2.27
uterine cancer KRAS_12-61 PTEN Any mutation 25 104 Signature 6 0.35 -0.45 1.13 1600.34 1.00 23 7 86 18 TRUE 0.41
colorectal cancer KRAS_12-61 PTEN Any mutation 625 156 Signature overall -0.21 -1.18 0.72 1472.18 1.00 886 574 105 51 TRUE 0.19
non-small cell lung cancer KRAS_12-61 PTEN Any mutation 350 54 Signature overall -0.74 -2.02 0.25 22.86 1.06 636 340 44 10 TRUE 0.74
uterine cancer KRAS_12-61 PTEN Any mutation 179 545 Signature overall 0.80 0.29 1.33 1501.82 1.00 340 49 415 130 TRUE 2.45
colorectal cancer KRAS_12-61 BCOR Any mutation 12 11 Signature 10 -0.63 -2.14 0.61 1395.21 1.00 16 10 9 2 FALSE 0.43
colorectal cancer KRAS_12-61 BCOR Any mutation 164 13 Signature 15 -0.32 -1.30 0.60 1453.21 1.00 214 159 8 5 FALSE 0.28
colorectal cancer KRAS_12-61 BCOR Any mutation 331 27 Signature 1A 0.56 -0.19 1.30 1314.45 1.00 503 315 11 16 FALSE 0.85
colorectal cancer KRAS_12-61 BCOR Any mutation 114 49 Signature 6 -0.91 -1.67 -0.23 1174.22 1.00 171 105 40 9 FALSE 1.89
non-small cell lung cancer KRAS_12-61 BCOR Any mutation 85 13 Signature 2 0.26 -0.78 1.15 1171.49 1.00 231 81 9 4 FALSE 0.22
non-small cell lung cancer KRAS_12-61 BCOR Any mutation 270 52 Signature 4 0.52 -0.01 1.05 1406.79 1.00 413 244 26 26 FALSE 1.25
uterine cancer KRAS_12-61 BCOR Any mutation 39 30 Signature 1A 0.16 -0.80 1.07 1349.62 1.00 158 33 24 6 FALSE 0.14
uterine cancer KRAS_12-61 BCOR Any mutation 19 23 Signature 6 0.98 0.00 2.01 1492.03 1.00 69 11 15 8 FALSE 1.23
colorectal cancer KRAS_12-61 BCOR Any mutation 621 100 Signature overall -0.32 -1.54 0.89 1254.45 1.00 904 589 68 32 FALSE 0.22
non-small cell lung cancer KRAS_12-61 BCOR Any mutation 355 65 Signature overall 0.38 -0.84 1.54 1548.73 1.00 644 325 35 30 FALSE 0.28
uterine cancer KRAS_12-61 BCOR Any mutation 60 83 Signature overall 0.30 -1.31 1.89 1553.79 1.00 248 45 68 15 FALSE 0.14
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 164 22 Signature 15 0.41 -0.23 0.96 1389.28 1.00 210 154 12 10 TRUE 0.76
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 334 61 Signature 1A 0.74 0.28 1.24 1452.36 1.00 491 296 23 38 TRUE 2.62
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 112 33 Signature 6 0.53 -0.04 1.08 1349.91 1.00 183 98 19 14 TRUE 1.23
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 47 11 Signature 1A -1.44 -2.85 -0.08 1556.04 1.00 209 46 10 1 TRUE 1.37
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 84 14 Signature 2 -1.62 -3.06 -0.37 1430.67 1.00 227 83 13 1 TRUE 1.80
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 54 17 Signature 3 -1.13 -2.39 0.07 1393.83 1.00 175 51 14 3 TRUE 1.14
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 266 16 Signature 4 -2.02 -3.63 -0.86 1342.77 1.00 420 266 16 0 TRUE 2.38
uterine cancer KRAS_12-61 CTNNB1 Any mutation 26 11 Signature 15 -1.63 -3.15 -0.32 273.43 1.02 74 25 10 1 TRUE 1.62
uterine cancer KRAS_12-61 CTNNB1 Any mutation 39 31 Signature 1A -1.60 -2.87 -0.44 192.62 1.02 152 37 29 2 TRUE 1.92
uterine cancer KRAS_12-61 CTNNB1 Any mutation 17 19 Signature 6 -1.70 -3.31 -0.36 774.55 1.01 64 16 18 1 TRUE 1.64
colorectal cancer KRAS_12-61 CTNNB1 Any mutation 610 116 Signature overall 0.56 -0.01 1.12 1390.39 1.00 884 548 54 62 TRUE 1.32
non-small cell lung cancer KRAS_12-61 CTNNB1 Any mutation 451 58 Signature overall -1.55 -2.77 -0.44 1519.63 1.00 1031 446 53 5 TRUE 2.18
uterine cancer KRAS_12-61 CTNNB1 Any mutation 85 83 Signature overall -1.70 -3.05 -0.50 190.49 1.02 356 81 79 4 TRUE 2.04
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 37 22 Signature 1A -0.77 -1.69 0.15 1399.30 1.00 68 32 17 5 TRUE 0.97
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 6 13 Signature 2 -0.93 -2.18 0.17 1240.43 1.00 38 5 12 1 TRUE 0.94
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 21 12 Signature 4 -0.88 -2.00 0.12 1513.50 1.00 50 19 10 2 TRUE 1.00
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 6 11 Signature 6 -1.14 -2.62 -0.04 1325.41 1.00 15 6 11 0 TRUE 1.08
colorectal cancer KRAS_12-61 ARID1A Any mutation 13 13 Signature 10 -0.60 -1.57 0.31 1422.84 1.00 16 10 10 3 TRUE 0.72
colorectal cancer KRAS_12-61 ARID1A Any mutation 166 39 Signature 15 -0.81 -1.43 -0.22 1479.77 1.00 206 156 29 10 TRUE 2.01
colorectal cancer KRAS_12-61 ARID1A Any mutation 343 130 Signature 1A -0.37 -0.74 0.02 1427.19 1.00 453 300 87 43 TRUE 1.23
colorectal cancer KRAS_12-61 ARID1A Any mutation 115 99 Signature 6 -0.77 -1.27 -0.31 1331.24 1.00 149 94 78 21 TRUE 2.66
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 14 17 Signature 13 -1.19 -3.00 0.19 1559.47 1.00 69 14 17 0 TRUE 0.86
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 69 12 Signature 18 0.77 -0.30 1.95 1584.77 1.00 81 60 3 9 TRUE 0.81
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 88 52 Signature 2 0.56 -0.06 1.16 1589.05 1.00 213 68 32 20 TRUE 1.17
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 54 11 Signature 3 -0.37 -1.63 0.75 1467.40 1.00 180 52 9 2 TRUE 0.26
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 267 86 Signature 4 -0.68 -1.21 -0.19 1474.07 1.00 373 246 65 21 TRUE 2.09
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 154 13 Signature R2 -0.39 -1.37 0.60 1519.63 1.00 40 145 4 9 TRUE 0.35
pancreatic cancer KRAS_12-61 ARID1A Any mutation 117 12 Signature 11 -0.44 -1.61 0.96 1260.84 1.00 8 106 1 11 TRUE 0.32
pancreatic cancer KRAS_12-61 ARID1A Any mutation 220 33 Signature 1A -0.49 -1.32 0.44 1413.25 1.00 29 194 7 26 TRUE 0.56
uterine cancer KRAS_12-61 ARID1A Any mutation 7 21 Signature 14 0.97 -0.12 2.05 1470.61 1.00 9 2 16 5 TRUE 1.12
uterine cancer KRAS_12-61 ARID1A Any mutation 32 58 Signature 15 1.15 0.46 1.89 1496.69 1.00 59 11 37 21 TRUE 2.71
uterine cancer KRAS_12-61 ARID1A Any mutation 52 133 Signature 1A 1.19 0.61 1.78 1497.49 1.00 116 14 95 38 TRUE 3.98
uterine cancer KRAS_12-61 ARID1A Any mutation 9 23 Signature 2 1.47 0.49 2.61 1327.80 1.00 28 1 15 8 TRUE 2.21
uterine cancer KRAS_12-61 ARID1A Any mutation 10 26 Signature 20 1.45 0.43 2.53 1438.39 1.00 20 1 17 9 TRUE 2.19
uterine cancer KRAS_12-61 ARID1A Any mutation 24 121 Signature 6 0.73 -0.13 1.59 1521.59 1.00 26 4 101 20 TRUE 0.99
cancer of unknown primary KRAS_12-61 ARID1A Any mutation 70 58 Signature overall -0.92 -1.92 0.02 1406.81 1.00 171 62 50 8 TRUE 1.17
colorectal cancer KRAS_12-61 ARID1A Any mutation 637 281 Signature overall -0.63 -1.30 -0.01 1425.23 1.00 824 560 204 77 TRUE 1.31
non-small cell lung cancer KRAS_12-61 ARID1A Any mutation 646 191 Signature overall -0.22 -1.15 0.68 1596.67 1.00 956 585 130 61 TRUE 0.19
pancreatic cancer KRAS_12-61 ARID1A Any mutation 337 45 Signature overall -0.44 -1.74 1.07 1354.49 1.00 37 300 8 37 TRUE 0.27
uterine cancer KRAS_12-61 ARID1A Any mutation 139 445 Signature overall 1.02 0.31 1.74 1427.05 1.00 276 34 340 105 TRUE 2.24
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 14 17 Signature 10 -0.42 -1.63 0.68 1458.28 1.00 14 10 13 4 TRUE 0.32
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 164 17 Signature 15 0.16 -0.69 1.01 1462.49 1.00 216 155 8 9 TRUE 0.14
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 332 31 Signature 1A -0.23 -0.95 0.46 1521.76 1.00 496 321 20 11 TRUE 0.29
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 112 31 Signature 6 -0.31 -1.11 0.40 1390.18 1.00 181 103 22 9 TRUE 0.38
uterine cancer KRAS_12-61 PIK3R1 Any mutation 29 32 Signature 15 0.58 -0.26 1.45 1434.30 1.00 68 15 18 14 TRUE 0.76
uterine cancer KRAS_12-61 PIK3R1 Any mutation 41 59 Signature 1A -0.35 -1.09 0.29 1263.59 1.00 134 34 52 7 TRUE 0.49
uterine cancer KRAS_12-61 PIK3R1 Any mutation 10 13 Signature 20 0.29 -0.60 1.35 1503.55 1.00 25 5 8 5 TRUE 0.25
uterine cancer KRAS_12-61 PIK3R1 Any mutation 18 31 Signature 6 -0.50 -1.54 0.32 1349.13 1.00 58 16 29 2 TRUE 0.52
colorectal cancer KRAS_12-61 PIK3R1 Any mutation 622 96 Signature overall -0.21 -1.24 0.84 1344.77 1.00 907 589 63 33 TRUE 0.16
uterine cancer KRAS_12-61 PIK3R1 Any mutation 104 167 Signature overall -0.05 -0.71 0.58 1435.38 1.00 323 74 137 30 TRUE 0.06
colorectal cancer KRAS_12-61 FAT1 Any mutation 21 44 Signature 10 -0.69 -1.70 0.30 1325.97 1.00 13 10 33 11 FALSE 0.78
colorectal cancer KRAS_12-61 FAT1 Any mutation 164 29 Signature 15 -1.73 -2.78 -0.80 1505.30 1.00 204 161 26 3 FALSE 3.13
colorectal cancer KRAS_12-61 FAT1 Any mutation 336 66 Signature 1A -0.28 -0.81 0.24 1354.02 1.00 479 313 43 23 FALSE 0.52
colorectal cancer KRAS_12-61 FAT1 Any mutation 115 67 Signature 6 -0.52 -1.11 0.06 1584.09 1.00 164 97 49 18 FALSE 1.05
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 14 16 Signature 13 0.09 -0.94 1.07 1494.49 1.00 72 12 14 2 FALSE 0.07
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 66 16 Signature 18 0.57 -0.21 1.41 1517.70 1.00 78 56 6 10 FALSE 0.80
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 47 13 Signature 1A 0.37 -0.59 1.30 1446.17 1.00 213 43 9 4 FALSE 0.37
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 86 38 Signature 2 0.20 -0.49 0.81 1523.57 1.00 217 75 27 11 FALSE 0.26
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 16 11 Signature 20 0.55 -0.40 1.46 1563.59 1.00 55 12 7 4 FALSE 0.60
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 54 13 Signature 3 0.59 -0.28 1.47 1494.64 1.00 182 48 7 6 FALSE 0.74
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 268 121 Signature 4 -0.32 -0.73 0.10 1470.07 1.00 362 233 86 35 FALSE 0.86
uterine cancer KRAS_12-61 FAT1 Any mutation 26 14 Signature 15 -0.28 -1.55 0.96 1419.48 1.00 75 23 11 3 FALSE 0.18
uterine cancer KRAS_12-61 FAT1 Any mutation 39 24 Signature 1A -0.90 -2.37 0.31 1519.61 1.00 162 37 22 2 FALSE 0.71
uterine cancer KRAS_12-61 FAT1 Any mutation 17 37 Signature 6 0.01 -1.07 0.98 1529.62 1.00 62 11 31 6 FALSE 0.01
colorectal cancer KRAS_12-61 FAT1 Any mutation 636 206 Signature overall -0.80 -1.95 0.45 1549.22 1.00 860 581 151 55 FALSE 0.72
non-small cell lung cancer KRAS_12-61 FAT1 Any mutation 551 228 Signature overall 0.29 -0.33 0.92 1657.84 1.00 1179 479 156 72 FALSE 0.45
uterine cancer KRAS_12-61 FAT1 Any mutation 86 149 Signature overall -0.28 -1.93 1.40 1475.38 1.00 311 71 134 15 FALSE 0.13
colorectal cancer KRAS_12-61 CIC Any mutation 165 19 Signature 15 -0.73 -1.56 0.00 1637.42 1.00 213 160 14 5 TRUE 1.25
colorectal cancer KRAS_12-61 CIC Any mutation 334 58 Signature 1A -0.25 -0.80 0.28 1468.38 1.00 485 312 36 22 TRUE 0.45
colorectal cancer KRAS_12-61 CIC Any mutation 112 43 Signature 6 -0.85 -1.63 -0.18 1389.17 1.00 174 105 36 7 TRUE 1.67
colorectal cancer KRAS_12-61 CIC Any mutation 611 120 Signature overall -0.60 -1.38 0.20 1433.17 1.00 872 577 86 34 TRUE 0.91
colorectal cancer KRAS_12-61 NCOR1 Any mutation 12 16 Signature 10 -0.99 -2.36 0.17 1119.26 1.00 14 10 14 2 FALSE 0.90
colorectal cancer KRAS_12-61 NCOR1 Any mutation 164 22 Signature 15 -0.32 -1.09 0.44 1391.42 1.00 211 155 13 9 FALSE 0.39
colorectal cancer KRAS_12-61 NCOR1 Any mutation 334 44 Signature 1A -0.63 -1.25 -0.02 1522.23 1.00 486 322 32 12 FALSE 1.32
colorectal cancer KRAS_12-61 NCOR1 Any mutation 112 43 Signature 6 -0.64 -1.37 0.04 1282.29 1.00 176 102 33 10 FALSE 1.14
non-small cell lung cancer KRAS_12-61 NCOR1 Any mutation 15 14 Signature 13 0.03 -1.24 1.30 1489.30 1.00 76 12 11 3 FALSE 0.02
non-small cell lung cancer KRAS_12-61 NCOR1 Any mutation 84 11 Signature 2 -0.27 -1.49 0.86 1333.89 1.00 235 81 8 3 FALSE 0.18
non-small cell lung cancer KRAS_12-61 NCOR1 Any mutation 267 36 Signature 4 -1.00 -1.81 -0.24 1395.28 1.00 407 261 30 6 FALSE 1.77
colorectal cancer KRAS_12-61 NCOR1 Any mutation 622 125 Signature overall -0.65 -1.59 0.32 1516.04 1.00 887 589 92 33 FALSE 0.74
non-small cell lung cancer KRAS_12-61 NCOR1 Any mutation 366 61 Signature overall -0.42 -1.62 0.86 1487.72 1.00 718 354 49 12 FALSE 0.30
colorectal cancer KRAS_12-61 POLE Any mutation 13 20 Signature 10 -0.74 -2.01 0.46 1414.00 1.00 13 9 16 4 TRUE 0.63
colorectal cancer KRAS_12-61 POLE Any mutation 164 19 Signature 15 -0.78 -1.76 0.13 1478.59 1.00 211 159 14 5 TRUE 1.01
colorectal cancer KRAS_12-61 POLE Any mutation 334 36 Signature 1A 0.16 -0.49 0.85 1379.48 1.00 497 317 19 17 TRUE 0.20
colorectal cancer KRAS_12-61 POLE Any mutation 112 54 Signature 6 -0.83 -1.50 -0.17 1487.10 1.00 166 101 43 11 TRUE 1.78
non-small cell lung cancer KRAS_12-61 POLE Any mutation 85 19 Signature 2 0.36 -0.56 1.24 1463.56 1.00 229 78 12 7 TRUE 0.36
non-small cell lung cancer KRAS_12-61 POLE Any mutation 266 49 Signature 4 -0.39 -1.02 0.18 1569.16 1.00 404 252 35 14 TRUE 0.71
non-small cell lung cancer KRAS_12-61 POLE Any mutation 154 11 Signature R2 0.18 -0.90 1.42 1447.37 1.00 42 145 2 9 TRUE 0.12
uterine cancer KRAS_12-61 POLE Any mutation 39 12 Signature 1A 0.34 -1.04 1.54 1565.78 1.00 172 36 9 3 TRUE 0.21
uterine cancer KRAS_12-61 POLE Any mutation 18 20 Signature 6 0.54 -0.65 1.68 1406.13 1.00 71 13 15 5 TRUE 0.44
colorectal cancer KRAS_12-61 POLE Any mutation 623 129 Signature overall -0.55 -1.72 0.71 1113.06 1.00 887 586 92 37 TRUE 0.43
non-small cell lung cancer KRAS_12-61 POLE Any mutation 505 79 Signature overall 0.02 -1.29 1.32 1095.36 1.00 675 475 49 30 TRUE 0.01
uterine cancer KRAS_12-61 POLE Any mutation 60 89 Signature overall 0.47 -1.84 3.04 1586.35 1.00 254 49 78 11 TRUE 0.15
non-small cell lung cancer KRAS_12-61 NOTCH2 Any mutation 84 15 Signature 2 -0.90 -2.10 0.11 1634.25 1.00 225 82 13 2 TRUE 1.02
non-small cell lung cancer KRAS_12-61 NOTCH2 Any mutation 266 54 Signature 4 -0.71 -1.36 -0.11 1734.62 1.00 405 253 41 13 TRUE 1.61
non-small cell lung cancer KRAS_12-61 NOTCH2 Any mutation 350 69 Signature overall -0.80 -2.10 0.36 1471.36 1.00 630 335 54 15 TRUE 0.69
colorectal cancer KRAS_12-61 TGFBR2 Any mutation 165 11 Signature 15 -0.37 -1.29 0.49 1574.94 1.00 214 161 7 4 TRUE 0.38
colorectal cancer KRAS_12-61 TGFBR2 Any mutation 332 48 Signature 1A 0.02 -0.52 0.56 1429.55 1.00 489 312 28 20 TRUE 0.02
colorectal cancer KRAS_12-61 TGFBR2 Any mutation 111 43 Signature 6 -0.30 -0.97 0.33 1536.67 1.00 171 99 31 12 TRUE 0.42
colorectal cancer KRAS_12-61 TGFBR2 Any mutation 608 102 Signature overall -0.22 -1.15 0.69 1658.90 1.00 874 572 66 36 TRUE 0.20
colorectal cancer KRAS_12-61 KMT2A Any mutation 16 22 Signature 10 -0.40 -1.49 0.65 1303.71 1.00 17 10 16 6 FALSE 0.34
colorectal cancer KRAS_12-61 KMT2A Any mutation 165 19 Signature 15 -1.25 -2.36 -0.30 1519.15 1.00 207 162 16 3 FALSE 1.77
colorectal cancer KRAS_12-61 KMT2A Any mutation 333 53 Signature 1A 0.13 -0.43 0.68 1508.47 1.00 488 309 29 24 FALSE 0.19
colorectal cancer KRAS_12-61 KMT2A Any mutation 112 42 Signature 6 -1.02 -1.85 -0.26 1620.04 1.00 174 105 35 7 FALSE 1.97
non-small cell lung cancer KRAS_12-61 KMT2A Any mutation 84 23 Signature 2 -0.17 -0.98 0.68 1393.30 1.00 225 78 17 6 FALSE 0.16
non-small cell lung cancer KRAS_12-61 KMT2A Any mutation 266 37 Signature 4 -0.35 -1.04 0.32 1491.56 1.00 411 255 26 11 FALSE 0.50
uterine cancer KRAS_12-61 KMT2A Any mutation 39 13 Signature 1A 0.53 -0.77 1.72 1522.84 1.00 171 35 9 4 FALSE 0.39
uterine cancer KRAS_12-61 KMT2A Any mutation 17 14 Signature 6 -1.01 -3.11 0.64 1449.97 1.00 68 16 13 1 FALSE 0.53
colorectal cancer KRAS_12-61 KMT2A Any mutation 626 136 Signature overall -0.64 -1.71 0.38 1454.88 1.00 886 586 96 40 FALSE 0.64
non-small cell lung cancer KRAS_12-61 KMT2A Any mutation 350 60 Signature overall -0.25 -1.30 0.85 1398.75 1.00 636 333 43 17 FALSE 0.18
uterine cancer KRAS_12-61 KMT2A Any mutation 59 81 Signature overall 0.06 -2.31 2.46 1343.48 1.00 257 51 73 8 FALSE 0.02
non-small cell lung cancer KRAS_12-61 PAK7 Any mutation 266 69 Signature 4 -0.33 -0.93 0.18 65.17 1.05 395 245 48 21 FALSE 0.56
non-small cell lung cancer KRAS_12-61 PAK7 Any mutation 266 69 Signature overall -0.27 -4.41 4.29 1598.84 1.00 395 245 48 21 FALSE 0.05
non-small cell lung cancer KRAS_12-61 STAG2 Any mutation 84 16 Signature 2 0.05 -0.92 0.86 1402.66 1.00 229 80 12 4 TRUE 0.04
non-small cell lung cancer KRAS_12-61 STAG2 Any mutation 267 43 Signature 4 0.24 -0.35 0.81 1308.00 1.00 415 248 24 19 TRUE 0.36
non-small cell lung cancer KRAS_12-61 STAG2 Any mutation 351 59 Signature overall 0.14 -0.95 1.12 1223.55 1.00 644 328 36 23 TRUE 0.10
non-small cell lung cancer KRAS_12-61 TERT Any mutation 85 23 Signature 2 0.71 -0.06 1.52 1229.65 1.00 228 74 12 11 TRUE 1.09
non-small cell lung cancer KRAS_12-61 TERT Any mutation 267 54 Signature 4 0.18 -0.35 0.70 1313.01 1.00 407 246 33 21 TRUE 0.28
non-small cell lung cancer KRAS_12-61 TERT Any mutation 352 77 Signature overall 0.44 -0.59 1.61 1519.38 1.00 635 320 45 32 TRUE 0.34
colorectal cancer KRAS_12-61 BRCA2 Any mutation 15 37 Signature 10 -1.60 -2.81 -0.47 1386.18 1.00 14 11 33 4 TRUE 2.14
colorectal cancer KRAS_12-61 BRCA2 Any mutation 164 17 Signature 15 -1.02 -2.09 0.03 1386.64 1.00 213 160 13 4 TRUE 1.21
colorectal cancer KRAS_12-61 BRCA2 Any mutation 336 50 Signature 1A 0.09 -0.47 0.65 1462.14 1.00 490 314 28 22 TRUE 0.12
colorectal cancer KRAS_12-61 BRCA2 Any mutation 114 62 Signature 6 -1.30 -2.04 -0.63 1486.02 1.00 163 105 53 9 TRUE 3.47
non-small cell lung cancer KRAS_12-61 BRCA2 Any mutation 14 13 Signature 13 -1.32 -3.57 0.08 1545.59 1.00 73 14 13 0 TRUE 0.80
non-small cell lung cancer KRAS_12-61 BRCA2 Any mutation 84 15 Signature 2 -0.92 -2.22 0.14 1404.70 1.00 228 82 13 2 TRUE 0.90
non-small cell lung cancer KRAS_12-61 BRCA2 Any mutation 267 55 Signature 4 -0.43 -1.01 0.15 1402.70 1.00 404 250 38 17 TRUE 0.82
uterine cancer KRAS_12-61 BRCA2 Any mutation 39 15 Signature 1A 0.39 -0.93 1.52 1485.32 1.00 169 35 11 4 TRUE 0.28
uterine cancer KRAS_12-61 BRCA2 Any mutation 17 22 Signature 6 -1.49 -3.65 0.07 1472.38 1.00 66 16 21 1 TRUE 0.92
colorectal cancer KRAS_12-61 BRCA2 Any mutation 629 166 Signature overall -0.95 -2.30 0.40 1565.29 1.00 880 590 127 39 TRUE 0.77
non-small cell lung cancer KRAS_12-61 BRCA2 Any mutation 365 83 Signature overall -0.89 -2.29 0.23 1235.23 1.00 705 346 64 19 TRUE 0.77
uterine cancer KRAS_12-61 BRCA2 Any mutation 60 102 Signature overall -0.14 -2.39 2.49 1577.10 1.00 250 51 93 9 TRUE 0.04
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 164 27 Signature 15 -0.48 -1.21 0.26 1580.33 1.00 209 154 17 10 TRUE 0.73
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 332 70 Signature 1A -0.66 -1.21 -0.15 1456.96 1.00 474 313 51 19 TRUE 1.87
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 112 72 Signature 6 -1.09 -1.77 -0.48 1468.27 1.00 158 101 61 11 TRUE 3.13
non-small cell lung cancer KRAS_12-61 NOTCH3 Any mutation 66 11 Signature 18 0.28 -0.57 1.31 1612.82 1.00 81 59 4 7 TRUE 0.27
non-small cell lung cancer KRAS_12-61 NOTCH3 Any mutation 84 15 Signature 2 -0.06 -0.88 0.71 1419.27 1.00 230 80 11 4 TRUE 0.05
non-small cell lung cancer KRAS_12-61 NOTCH3 Any mutation 266 48 Signature 4 -0.23 -0.86 0.34 1150.21 1.00 407 252 34 14 TRUE 0.34
colorectal cancer KRAS_12-61 NOTCH3 Any mutation 608 169 Signature overall -0.74 -1.63 0.09 1362.57 1.00 841 568 129 40 TRUE 1.02
non-small cell lung cancer KRAS_12-61 NOTCH3 Any mutation 416 74 Signature overall -0.01 -0.78 0.77 1354.81 1.00 718 391 49 25 TRUE 0.01
colorectal cancer KRAS_12-61 NOTCH4 Any mutation 160 18 Signature 15 -0.79 -1.66 -0.09 1455.51 1.00 205 156 14 4 TRUE 1.32
colorectal cancer KRAS_12-61 NOTCH4 Any mutation 320 43 Signature 1A -0.46 -1.07 0.13 1467.15 1.00 477 306 29 14 TRUE 0.88
colorectal cancer KRAS_12-61 NOTCH4 Any mutation 110 41 Signature 6 -0.54 -1.21 0.09 1420.62 1.00 168 100 31 10 TRUE 0.99
non-small cell lung cancer KRAS_12-61 NOTCH4 Any mutation 266 74 Signature 4 -0.48 -1.00 0.04 817.86 1.01 389 245 53 21 TRUE 1.18
colorectal cancer KRAS_12-61 NOTCH4 Any mutation 590 102 Signature overall -0.61 -1.42 0.10 1419.51 1.00 850 562 74 28 TRUE 0.90
non-small cell lung cancer KRAS_12-61 NOTCH4 Any mutation 266 74 Signature overall -0.41 -4.36 4.13 1151.70 1.00 389 245 53 21 TRUE 0.08
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 14 20 Signature 13 -0.03 -0.92 0.88 1495.09 1.00 66 12 18 2 FALSE 0.03
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 21 12 Signature 14 0.18 -0.75 1.02 1524.88 1.00 27 17 8 4 FALSE 0.16
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 31 16 Signature 15 0.69 -0.11 1.54 1427.27 1.00 97 24 9 7 FALSE 1.00
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 9 12 Signature 16 0.22 -0.89 1.17 1575.88 1.00 41 7 10 2 FALSE 0.17
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 67 34 Signature 18 0.30 -0.37 0.94 1438.17 1.00 67 51 18 16 FALSE 0.42
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 17 11 Signature 19 0.83 -0.08 1.74 1515.99 1.00 41 11 5 6 FALSE 1.13
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 47 27 Signature 1A 0.54 -0.22 1.26 1370.06 1.00 202 39 19 8 FALSE 0.79
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 84 55 Signature 2 -0.10 -0.74 0.44 1287.82 1.00 200 72 43 12 FALSE 0.13
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 15 13 Signature 20 0.50 -0.34 1.45 1396.22 1.00 53 11 9 4 FALSE 0.55
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 54 31 Signature 3 0.58 -0.12 1.23 1497.82 1.00 169 43 20 11 FALSE 1.04
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 270 175 Signature 4 0.01 -0.34 0.34 1457.06 1.00 329 205 110 65 FALSE 0.02
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 24 14 Signature 7 0.12 -0.85 1.02 1579.54 1.00 74 21 11 3 FALSE 0.10
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 155 45 Signature R2 0.23 -0.39 0.89 1434.18 1.00 34 121 11 34 FALSE 0.32
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 21 11 Signature U1 1.10 0.22 2.07 1527.50 1.00 86 14 4 7 FALSE 1.65
non-small cell lung cancer KRAS_12-61 KEAP1 Any mutation 829 476 Signature overall 0.37 -0.07 0.80 1377.61 1.00 1486 648 295 181 FALSE 1.05
non-small cell lung cancer KRAS_12-61 KDM5C Any mutation 84 15 Signature 2 -0.36 -1.83 0.70 1264.51 1.00 228 82 13 2 FALSE 0.24
non-small cell lung cancer KRAS_12-61 KDM5C Any mutation 267 41 Signature 4 0.55 -0.07 1.17 1567.36 1.00 418 245 19 22 FALSE 1.11
non-small cell lung cancer KRAS_12-61 KDM5C Any mutation 351 56 Signature overall 0.11 -1.50 1.42 1456.43 1.00 646 327 32 24 FALSE 0.06
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 14 12 Signature 13 -1.11 -2.92 0.37 1380.59 1.00 72 14 12 0 TRUE 0.75
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 31 11 Signature 15 -0.81 -2.26 0.41 1429.86 1.00 95 30 10 1 TRUE 0.63
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 47 18 Signature 1A 0.65 -0.30 1.56 1494.62 1.00 208 40 11 7 TRUE 0.75
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 84 22 Signature 2 -1.32 -2.65 -0.29 1283.36 1.00 220 83 21 1 TRUE 1.51
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 55 20 Signature 3 0.13 -0.90 1.07 1412.10 1.00 175 49 14 6 TRUE 0.10
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 269 90 Signature 4 -0.58 -1.09 -0.09 1290.87 1.00 375 245 66 24 TRUE 1.63
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 154 11 Signature R2 -0.10 -1.07 0.98 1462.23 1.00 42 145 2 9 TRUE 0.07
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 118 30 Signature 11 1.61 0.82 2.53 1350.05 1.00 8 89 1 29 TRUE 3.67
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 114 27 Signature 15 1.40 0.53 2.33 961.00 1.00 15 92 5 22 TRUE 2.71
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 51 11 Signature 17 1.59 0.74 2.55 1270.56 1.00 3 40 0 11 TRUE 3.34
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 222 67 Signature 1A 1.68 0.96 2.58 1337.52 1.00 32 157 2 65 TRUE 4.39
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 84 23 Signature 3 1.65 0.82 2.63 1412.15 1.00 18 61 0 23 TRUE 3.80
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 65 25 Signature 4 1.79 0.99 2.78 1222.53 1.00 9 40 0 25 TRUE 4.24
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 61 26 Signature 6 1.82 1.02 2.81 1204.56 1.00 13 35 0 26 TRUE 4.23
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 49 11 Signature 8 1.60 0.75 2.53 1288.72 1.00 3 38 0 11 TRUE 3.47
non-small cell lung cancer KRAS_12-61 CDKN2A Any mutation 654 184 Signature overall -0.44 -1.26 0.39 1501.76 1.00 1187 606 136 48 TRUE 0.53
pancreatic cancer KRAS_12-61 CDKN2A Any mutation 764 220 Signature overall 1.64 0.91 2.55 1255.93 1.00 101 552 8 212 TRUE 4.34
non-small cell lung cancer KRAS_12-61 EPHB1 Any mutation 84 17 Signature 2 -0.39 -1.46 0.70 1553.72 1.00 228 80 13 4 FALSE 0.34
non-small cell lung cancer KRAS_12-61 EPHB1 Any mutation 268 79 Signature 4 -0.67 -1.20 -0.14 1337.45 1.00 386 249 60 19 FALSE 1.97
non-small cell lung cancer KRAS_12-61 EPHB1 Any mutation 352 96 Signature overall -0.54 -2.00 0.89 1108.08 1.00 614 329 73 23 FALSE 0.35
uterine cancer KRAS_12-61 PPP2R1A Any mutation 26 20 Signature 15 -1.04 -2.27 -0.03 1368.58 1.00 66 24 18 2 FALSE 1.21
uterine cancer KRAS_12-61 PPP2R1A Any mutation 39 25 Signature 1A -1.00 -2.15 0.01 1451.91 1.00 159 37 23 2 FALSE 1.16
uterine cancer KRAS_12-61 PPP2R1A Any mutation 10 14 Signature 3 -0.82 -2.01 0.41 1387.71 1.00 23 8 12 2 FALSE 0.73
uterine cancer KRAS_12-61 PPP2R1A Any mutation 17 17 Signature 6 -0.59 -1.77 0.60 1713.93 1.00 71 14 14 3 FALSE 0.48
uterine cancer KRAS_12-61 PPP2R1A Any mutation 93 96 Signature overall -0.91 -1.94 0.09 1477.61 1.00 351 84 87 9 FALSE 1.12
colorectal cancer KRAS_12-61 ERBB3 Any mutation 164 18 Signature 15 -0.15 -0.86 0.46 1472.06 1.00 209 158 12 6 TRUE 0.19
colorectal cancer KRAS_12-61 ERBB3 Any mutation 333 46 Signature 1A 0.02 -0.44 0.54 1206.79 1.00 493 314 27 19 TRUE 0.03
colorectal cancer KRAS_12-61 ERBB3 Any mutation 112 34 Signature 6 0.18 -0.38 0.78 1356.62 1.00 184 98 20 14 TRUE 0.26
colorectal cancer KRAS_12-61 ERBB3 Any mutation 609 98 Signature overall 0.01 -0.60 0.60 1499.93 1.00 886 570 59 39 TRUE 0.02
colorectal cancer KRAS_12-61 SMAD4 Any mutation 13 17 Signature 10 0.14 -0.47 0.73 1450.15 1.00 14 8 12 5 TRUE 0.20
colorectal cancer KRAS_12-61 SMAD4 Any mutation 165 60 Signature 15 0.12 -0.28 0.50 1318.97 1.00 193 137 32 28 TRUE 0.25
colorectal cancer KRAS_12-61 SMAD4 Any mutation 14 11 Signature 17 0.00 -0.71 0.60 1538.10 1.00 23 12 9 2 TRUE 0.00
colorectal cancer KRAS_12-61 SMAD4 Any mutation 21 12 Signature 19 0.25 -0.33 0.89 1117.40 1.00 20 14 5 7 TRUE 0.39
colorectal cancer KRAS_12-61 SMAD4 Any mutation 337 122 Signature 1A 0.00 -0.34 0.33 1680.96 1.00 444 289 74 48 TRUE 0.00
colorectal cancer KRAS_12-61 SMAD4 Any mutation 44 11 Signature 2 0.12 -0.42 0.68 1560.06 1.00 34 37 4 7 TRUE 0.18
colorectal cancer KRAS_12-61 SMAD4 Any mutation 113 57 Signature 6 0.03 -0.41 0.45 1439.20 1.00 169 93 37 20 TRUE 0.04
colorectal cancer KRAS_12-61 SMAD4 Any mutation 15 11 Signature 7 0.27 -0.33 0.91 1578.84 1.00 20 9 5 6 TRUE 0.40
non-small cell lung cancer KRAS_12-61 SMAD4 Any mutation 47 17 Signature 1A -0.14 -1.40 0.84 1535.64 1.00 206 45 15 2 TRUE 0.09
non-small cell lung cancer KRAS_12-61 SMAD4 Any mutation 84 21 Signature 2 0.78 -0.04 1.61 1436.68 1.00 229 74 11 10 TRUE 1.19
non-small cell lung cancer KRAS_12-61 SMAD4 Any mutation 266 16 Signature 4 -0.02 -0.88 0.80 1362.39 1.00 426 260 10 6 TRUE 0.01
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 116 25 Signature 11 0.44 -0.08 1.02 877.52 1.00 8 92 1 24 TRUE 0.92
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 113 31 Signature 15 0.47 -0.04 1.05 849.76 1.00 17 85 3 28 TRUE 1.02
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 52 12 Signature 17 0.47 -0.06 1.09 878.86 1.00 3 40 0 12 TRUE 0.94
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 219 56 Signature 1A 0.48 -0.03 1.05 808.84 1.00 31 166 3 53 TRUE 1.07
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 33 12 Signature 2 0.40 -0.21 0.99 918.27 1.00 8 26 5 7 TRUE 0.73
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 81 24 Signature 3 0.46 -0.08 1.03 828.37 1.00 15 60 3 21 TRUE 0.98
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 64 15 Signature 4 0.44 -0.10 1.00 848.28 1.00 8 50 1 14 TRUE 0.91
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 61 15 Signature 6 0.39 -0.17 0.97 943.01 1.00 9 50 4 11 TRUE 0.74
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 50 15 Signature 8 0.52 -0.02 1.15 799.93 1.00 3 35 0 15 TRUE 1.07
colorectal cancer KRAS_12-61 SMAD4 Any mutation 722 301 Signature overall 0.12 -0.25 0.47 1145.96 1.00 917 599 178 123 TRUE 0.27
non-small cell lung cancer KRAS_12-61 SMAD4 Any mutation 397 54 Signature overall 0.19 -0.93 1.24 1691.58 1.00 861 379 36 18 TRUE 0.14
pancreatic cancer KRAS_12-61 SMAD4 Any mutation 789 205 Signature overall 0.46 -0.04 0.99 745.38 1.00 102 604 20 185 TRUE 1.09
colorectal cancer KRAS_12-61 ATM Any mutation 19 39 Signature 10 -0.45 -1.42 0.47 1515.78 1.00 13 9 29 10 TRUE 0.47
colorectal cancer KRAS_12-61 ATM Any mutation 166 32 Signature 15 -0.18 -0.88 0.48 1557.91 1.00 205 153 19 13 TRUE 0.21
colorectal cancer KRAS_12-61 ATM Any mutation 335 77 Signature 1A 0.27 -0.22 0.74 1427.90 1.00 479 299 41 36 TRUE 0.57
colorectal cancer KRAS_12-61 ATM Any mutation 112 48 Signature 6 -1.02 -1.81 -0.32 1536.81 1.00 168 104 40 8 TRUE 2.18
non-small cell lung cancer KRAS_12-61 ATM Any mutation 14 12 Signature 13 1.05 0.02 2.13 1346.77 1.00 76 10 8 4 TRUE 1.32
non-small cell lung cancer KRAS_12-61 ATM Any mutation 66 11 Signature 18 0.60 -0.37 1.56 1341.32 1.00 80 60 5 6 TRUE 0.66
non-small cell lung cancer KRAS_12-61 ATM Any mutation 86 27 Signature 2 0.88 0.15 1.58 1486.51 1.00 226 74 15 12 TRUE 1.85
non-small cell lung cancer KRAS_12-61 ATM Any mutation 54 13 Signature 3 0.74 -0.22 1.65 1467.19 1.00 181 49 8 5 TRUE 0.93
non-small cell lung cancer KRAS_12-61 ATM Any mutation 278 95 Signature 4 0.78 0.36 1.21 1541.05 1.00 398 226 43 52 TRUE 3.51
non-small cell lung cancer KRAS_12-61 ATM Any mutation 155 25 Signature R2 0.71 -0.12 1.53 1574.61 1.00 40 134 4 21 TRUE 0.98
non-small cell lung cancer KRAS_12-61 ATM Any mutation 14 12 Signature U2 1.67 0.62 2.73 1396.05 1.00 29 6 4 8 TRUE 2.82
uterine cancer KRAS_12-61 ATM Any mutation 6 11 Signature 14 -0.44 -2.09 1.03 1447.82 1.00 10 4 9 2 TRUE 0.23
uterine cancer KRAS_12-61 ATM Any mutation 39 23 Signature 1A -0.50 -1.75 0.55 1542.16 1.00 164 36 20 3 TRUE 0.41
uterine cancer KRAS_12-61 ATM Any mutation 18 24 Signature 6 -0.51 -1.84 0.59 1482.17 1.00 67 15 21 3 TRUE 0.37
colorectal cancer KRAS_12-61 ATM Any mutation 632 196 Signature overall -0.34 -1.42 0.86 1422.03 1.00 865 565 129 67 TRUE 0.27
non-small cell lung cancer KRAS_12-61 ATM Any mutation 667 195 Signature overall 0.93 0.22 1.65 1570.23 1.00 1030 559 87 108 TRUE 2.00
uterine cancer KRAS_12-61 ATM Any mutation 67 121 Signature overall -0.34 -1.85 1.24 1471.73 1.00 254 55 109 12 TRUE 0.17
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 14 11 Signature 13 -0.68 -1.68 0.40 1423.06 1.00 77 12 9 2 TRUE 0.71
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 66 11 Signature 18 -0.74 -1.59 0.08 1447.69 1.00 77 62 7 4 TRUE 1.06
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 47 16 Signature 1A -0.84 -1.81 0.06 1553.00 1.00 205 45 14 2 TRUE 1.09
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 84 28 Signature 2 -1.00 -1.91 -0.23 1384.12 1.00 215 81 25 3 TRUE 1.68
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 54 18 Signature 3 -1.26 -2.31 -0.34 1303.03 1.00 171 54 18 0 TRUE 1.88
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 266 67 Signature 4 -0.89 -1.46 -0.35 1407.41 1.00 387 252 53 14 TRUE 2.80
non-small cell lung cancer KRAS_12-61 RB1 Any mutation 531 151 Signature overall -0.90 -1.54 -0.27 1438.49 1.00 1132 506 126 25 TRUE 2.20
cancer of unknown primary KRAS_12-61 KMT2D Any mutation 35 18 Signature 1A -1.23 -2.49 -0.06 1073.38 1.00 68 32 15 3 FALSE 1.34
cancer of unknown primary KRAS_12-61 KMT2D Any mutation 21 15 Signature 4 -1.31 -2.80 0.03 1483.50 1.00 48 19 13 2 FALSE 1.19
cancer of unknown primary KRAS_12-61 KMT2D Any mutation 6 13 Signature 6 -1.97 -4.00 -0.35 1184.01 1.00 13 6 13 0 FALSE 1.46
colorectal cancer KRAS_12-61 KMT2D Any mutation 13 19 Signature 10 -1.04 -2.11 -0.06 1540.64 1.00 13 10 16 3 FALSE 1.41
colorectal cancer KRAS_12-61 KMT2D Any mutation 165 55 Signature 15 -1.12 -1.77 -0.51 1581.57 1.00 199 154 44 11 FALSE 3.45
colorectal cancer KRAS_12-61 KMT2D Any mutation 342 128 Signature 1A -0.54 -0.92 -0.14 1351.62 1.00 460 304 90 38 FALSE 2.20
colorectal cancer KRAS_12-61 KMT2D Any mutation 123 142 Signature 6 -0.95 -1.41 -0.51 1337.41 1.00 137 94 113 29 FALSE 4.40
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 14 16 Signature 13 -1.35 -2.97 0.01 1413.62 1.00 69 14 16 0 FALSE 1.16
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 66 16 Signature 18 -0.90 -1.87 0.01 1581.09 1.00 74 62 12 4 FALSE 1.17
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 47 22 Signature 1A -0.89 -1.98 0.15 1554.99 1.00 202 45 20 2 FALSE 0.96
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 85 46 Signature 2 -0.27 -1.01 0.38 1479.81 1.00 211 74 35 11 FALSE 0.35
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 54 13 Signature 3 -1.11 -2.45 0.09 1532.95 1.00 177 53 12 1 FALSE 1.09
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 269 129 Signature 4 -0.70 -1.15 -0.28 1601.12 1.00 359 237 97 32 FALSE 2.77
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 154 13 Signature R2 -0.40 -1.34 0.52 1638.61 1.00 41 144 3 10 FALSE 0.41
uterine cancer KRAS_12-61 KMT2D Any mutation 8 24 Signature 14 -0.01 -1.08 1.03 1611.40 1.00 9 3 19 5 FALSE 0.01
uterine cancer KRAS_12-61 KMT2D Any mutation 27 27 Signature 15 0.11 -0.73 0.94 1359.35 1.00 68 19 19 8 FALSE 0.10
uterine cancer KRAS_12-61 KMT2D Any mutation 40 61 Signature 1A -0.38 -1.10 0.32 1467.05 1.00 138 32 53 8 FALSE 0.53
uterine cancer KRAS_12-61 KMT2D Any mutation 9 13 Signature 20 -0.06 -1.12 1.05 1586.60 1.00 24 6 10 3 FALSE 0.04
uterine cancer KRAS_12-61 KMT2D Any mutation 19 63 Signature 6 -0.25 -1.01 0.55 1508.70 1.00 44 10 54 9 FALSE 0.27
cancer of unknown primary KRAS_12-61 KMT2D Any mutation 65 76 Signature overall -1.48 -2.89 -0.22 1241.35 1.00 160 59 70 6 FALSE 1.50
colorectal cancer KRAS_12-61 KMT2D Any mutation 643 344 Signature overall -0.90 -1.63 -0.23 1814.07 1.00 809 562 263 81 FALSE 1.92
non-small cell lung cancer KRAS_12-61 KMT2D Any mutation 689 255 Signature overall -0.80 -1.54 -0.05 1475.58 1.00 1133 629 195 60 FALSE 1.45
uterine cancer KRAS_12-61 KMT2D Any mutation 107 233 Signature overall -0.14 -0.87 0.56 1626.89 1.00 302 71 197 36 FALSE 0.15
colorectal cancer KRAS_12-61 TSC2 Any mutation 164 11 Signature 15 0.06 -0.95 1.19 1449.02 1.00 216 158 5 6 TRUE 0.04
colorectal cancer KRAS_12-61 TSC2 Any mutation 334 36 Signature 1A -0.01 -0.63 0.67 1473.16 1.00 497 319 21 15 TRUE 0.01
colorectal cancer KRAS_12-61 TSC2 Any mutation 111 44 Signature 6 -1.12 -2.03 -0.33 1486.58 1.00 171 105 38 6 TRUE 1.97
colorectal cancer KRAS_12-61 TSC2 Any mutation 609 91 Signature overall -0.36 -1.58 1.01 1445.71 1.00 884 582 64 27 TRUE 0.23
colorectal cancer KRAS_12-61 APC Any mutation 30 94 Signature 10 0.19 -0.29 0.73 1389.57 1.00 3 0 64 30 TRUE 0.33
colorectal cancer KRAS_12-61 APC Any mutation 31 39 Signature 11 0.24 -0.32 0.73 1362.55 1.00 1 9 17 22 TRUE 0.42
colorectal cancer KRAS_12-61 APC Any mutation 13 25 Signature 14 0.30 -0.29 0.90 1336.58 1.00 2 1 13 12 TRUE 0.50
colorectal cancer KRAS_12-61 APC Any mutation 255 469 Signature 15 0.53 0.19 0.90 1421.57 1.00 58 25 239 230 TRUE 2.33
colorectal cancer KRAS_12-61 APC Any mutation 21 46 Signature 17 0.13 -0.37 0.61 1404.90 1.00 11 4 29 17 TRUE 0.22
colorectal cancer KRAS_12-61 APC Any mutation 24 63 Signature 18 0.01 -0.52 0.49 1503.55 1.00 3 5 44 19 TRUE 0.01
colorectal cancer KRAS_12-61 APC Any mutation 26 38 Signature 19 0.09 -0.45 0.59 1600.28 1.00 9 9 21 17 TRUE 0.13
colorectal cancer KRAS_12-61 APC Any mutation 481 962 Signature 1A 0.08 -0.19 0.33 1378.38 1.00 132 89 570 392 TRUE 0.25
colorectal cancer KRAS_12-61 APC Any mutation 14 22 Signature 1B 0.37 -0.18 0.96 1251.55 1.00 7 1 9 13 TRUE 0.68
colorectal cancer KRAS_12-61 APC Any mutation 64 95 Signature 2 0.41 -0.05 0.89 1529.85 1.00 8 9 40 55 TRUE 1.05
colorectal cancer KRAS_12-61 APC Any mutation 18 34 Signature 20 0.16 -0.41 0.70 1449.45 1.00 4 4 20 14 TRUE 0.26
colorectal cancer KRAS_12-61 APC Any mutation 13 25 Signature 21 0.33 -0.23 0.87 1498.36 1.00 10 0 12 13 TRUE 0.61
colorectal cancer KRAS_12-61 APC Any mutation 21 42 Signature 3 0.23 -0.31 0.76 1438.90 1.00 8 3 24 18 TRUE 0.39
colorectal cancer KRAS_12-61 APC Any mutation 25 49 Signature 4 0.16 -0.38 0.67 1497.38 1.00 6 5 29 20 TRUE 0.25
colorectal cancer KRAS_12-61 APC Any mutation 166 355 Signature 6 0.16 -0.20 0.50 1527.70 1.00 64 31 220 135 TRUE 0.40
colorectal cancer KRAS_12-61 APC Any mutation 22 40 Signature 7 0.27 -0.24 0.82 1402.90 1.00 9 3 21 19 TRUE 0.49
colorectal cancer KRAS_12-61 APC Any mutation 19 30 Signature 8 0.40 -0.13 0.98 1439.30 1.00 1 2 13 17 TRUE 0.79
colorectal cancer KRAS_12-61 APC Any mutation 21 20 Signature R2 0.31 -0.25 0.85 1261.88 1.00 2 7 6 14 TRUE 0.56
colorectal cancer KRAS_12-61 APC Any mutation 10 14 Signature U1 0.14 -0.45 0.68 1575.37 1.00 2 4 8 6 TRUE 0.19
non-small cell lung cancer KRAS_12-61 APC Any mutation 47 13 Signature 1A -0.28 -1.30 0.65 1446.58 1.00 208 45 11 2 TRUE 0.23
non-small cell lung cancer KRAS_12-61 APC Any mutation 87 23 Signature 2 -0.05 -0.84 0.78 1530.18 1.00 224 80 16 7 TRUE 0.04
non-small cell lung cancer KRAS_12-61 APC Any mutation 266 50 Signature 4 -0.39 -0.97 0.19 1499.07 1.00 404 252 36 14 TRUE 0.75
uterine cancer KRAS_12-61 APC Any mutation 6 63 Signature 10 1.16 -0.72 4.18 1451.98 1.00 17 0 57 6 TRUE 0.47
uterine cancer KRAS_12-61 APC Any mutation 40 18 Signature 1A 0.50 -0.63 1.53 1598.31 1.00 171 35 13 5 TRUE 0.43
uterine cancer KRAS_12-61 APC Any mutation 17 15 Signature 6 -0.29 -1.94 1.06 1373.40 1.00 72 15 13 2 TRUE 0.15
colorectal cancer KRAS_12-61 APC Any mutation 1274 2462 Signature overall 0.24 -0.04 0.53 1292.68 1.00 340 211 1399 1063 TRUE 0.99
non-small cell lung cancer KRAS_12-61 APC Any mutation 400 86 Signature overall -0.24 -1.07 0.56 1685.12 1.00 836 377 63 23 TRUE 0.25
uterine cancer KRAS_12-61 APC Any mutation 63 96 Signature overall 0.45 -1.88 2.93 1454.09 1.00 260 50 83 13 TRUE 0.16
colorectal cancer KRAS_12-61 ERBB2 Any mutation 332 47 Signature 1A -0.38 -0.95 0.18 923.82 1.00 486 317 32 15 TRUE 0.72
colorectal cancer KRAS_12-61 ERBB2 Any mutation 111 29 Signature 6 -0.38 -1.08 0.30 804.20 1.00 183 103 21 8 TRUE 0.55
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 47 15 Signature 1A -0.94 -2.20 0.23 1482.97 1.00 206 45 13 2 TRUE 0.87
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 84 12 Signature 2 -1.22 -2.58 -0.05 1457.19 1.00 229 83 11 1 TRUE 1.23
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 266 19 Signature 4 -1.21 -2.35 -0.23 1241.71 1.00 422 263 16 3 TRUE 1.59
colorectal cancer KRAS_12-61 ERBB2 Any mutation 443 76 Signature overall -0.38 -1.25 0.48 1232.02 1.00 669 420 53 23 TRUE 0.39
non-small cell lung cancer KRAS_12-61 ERBB2 Any mutation 397 46 Signature overall -1.11 -2.25 0.01 1423.65 1.00 857 391 40 6 TRUE 1.24
uterine cancer KRAS_12-61 JAK1 Any mutation 29 14 Signature 15 1.02 0.04 2.02 1476.41 1.00 77 22 7 7 TRUE 1.36
uterine cancer KRAS_12-61 JAK1 Any mutation 42 35 Signature 1A 1.09 0.36 1.86 1467.34 1.00 160 29 22 13 TRUE 2.31
uterine cancer KRAS_12-61 JAK1 Any mutation 18 42 Signature 6 0.66 -0.22 1.50 1504.77 1.00 58 9 33 9 TRUE 0.84
uterine cancer KRAS_12-61 JAK1 Any mutation 92 117 Signature overall 0.80 -0.30 1.97 1604.86 1.00 318 61 86 31 TRUE 0.80
colorectal cancer KRAS_12-61 ARID2 Any mutation 12 16 Signature 10 -0.64 -1.85 0.48 1544.77 1.00 14 9 13 3 FALSE 0.52
colorectal cancer KRAS_12-61 ARID2 Any mutation 164 19 Signature 15 -0.73 -1.67 0.12 1289.40 1.00 210 159 14 5 FALSE 0.95
colorectal cancer KRAS_12-61 ARID2 Any mutation 333 42 Signature 1A 0.08 -0.50 0.68 1660.33 1.00 494 314 23 19 FALSE 0.11
colorectal cancer KRAS_12-61 ARID2 Any mutation 111 27 Signature 6 -0.52 -1.39 0.26 1516.46 1.00 182 104 20 7 FALSE 0.66
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 66 11 Signature 18 -0.07 -0.88 0.76 1503.96 1.00 79 60 5 6 FALSE 0.06
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 84 18 Signature 2 -0.23 -1.07 0.58 1466.79 1.00 228 79 13 5 FALSE 0.24
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 54 16 Signature 3 -0.45 -1.38 0.41 1486.00 1.00 175 52 14 2 FALSE 0.50
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 267 67 Signature 4 -0.48 -1.02 0.03 1366.58 1.00 394 250 50 17 FALSE 1.12
colorectal cancer KRAS_12-61 ARID2 Any mutation 620 104 Signature overall -0.44 -1.54 0.54 1499.29 1.00 900 586 70 34 FALSE 0.40
non-small cell lung cancer KRAS_12-61 ARID2 Any mutation 471 112 Signature overall -0.30 -1.00 0.37 1455.67 1.00 876 441 82 30 FALSE 0.41
colorectal cancer KRAS_12-61 MTOR Any mutation 12 12 Signature 10 -0.99 -2.47 0.22 1606.77 1.00 16 11 11 1 TRUE 0.80
colorectal cancer KRAS_12-61 MTOR Any mutation 164 17 Signature 15 -0.28 -1.18 0.54 1543.98 1.00 213 157 10 7 TRUE 0.29
colorectal cancer KRAS_12-61 MTOR Any mutation 335 48 Signature 1A 0.03 -0.52 0.59 1449.53 1.00 489 314 27 21 TRUE 0.04
colorectal cancer KRAS_12-61 MTOR Any mutation 114 45 Signature 6 -0.68 -1.39 -0.04 1396.73 1.00 171 104 35 10 TRUE 1.30
non-small cell lung cancer KRAS_12-61 MTOR Any mutation 266 41 Signature 4 0.04 -0.62 0.66 1105.95 1.00 411 250 25 16 TRUE 0.04
colorectal cancer KRAS_12-61 MTOR Any mutation 625 122 Signature overall -0.48 -1.52 0.50 1359.53 1.00 889 586 83 39 TRUE 0.48
non-small cell lung cancer KRAS_12-61 MTOR Any mutation 266 41 Signature overall 0.04 -4.34 4.46 1300.35 1.00 411 250 25 16 TRUE 0.01
colorectal cancer KRAS_12-61 NOTCH1 Any mutation 12 11 Signature 10 -1.89 -4.31 -0.28 1285.05 1.01 16 12 11 0 TRUE 1.17
colorectal cancer KRAS_12-61 NOTCH1 Any mutation 166 17 Signature 15 -0.95 -2.00 0.03 1331.59 1.00 212 162 13 4 TRUE 1.16
colorectal cancer KRAS_12-61 NOTCH1 Any mutation 338 47 Signature 1A 0.23 -0.37 0.84 1457.88 1.00 490 315 24 23 TRUE 0.33
colorectal cancer KRAS_12-61 NOTCH1 Any mutation 117 82 Signature 6 -0.66 -1.20 -0.11 1437.54 1.00 155 97 62 20 TRUE 1.76
non-small cell lung cancer KRAS_12-61 NOTCH1 Any mutation 84 12 Signature 2 -0.89 -2.24 0.33 1553.92 1.00 230 82 10 2 TRUE 0.80
non-small cell lung cancer KRAS_12-61 NOTCH1 Any mutation 266 54 Signature 4 -1.02 -1.75 -0.35 1600.07 1.00 395 256 44 10 TRUE 2.39
colorectal cancer KRAS_12-61 NOTCH1 Any mutation 633 157 Signature overall -0.82 -2.18 0.36 1425.95 1.00 873 586 110 47 TRUE 0.71
non-small cell lung cancer KRAS_12-61 NOTCH1 Any mutation 350 66 Signature overall -0.90 -2.29 0.83 1492.39 1.00 625 338 54 12 TRUE 0.60
colorectal cancer KRAS_12-61 SETD2 Any mutation 16 22 Signature 10 -0.48 -1.55 0.55 1230.53 1.00 14 10 16 6 FALSE 0.42
colorectal cancer KRAS_12-61 SETD2 Any mutation 165 13 Signature 15 -0.97 -2.14 0.08 1381.18 1.00 212 162 10 3 FALSE 1.05
colorectal cancer KRAS_12-61 SETD2 Any mutation 331 31 Signature 1A -0.43 -1.16 0.26 1559.53 1.00 495 321 21 10 FALSE 0.62
colorectal cancer KRAS_12-61 SETD2 Any mutation 113 39 Signature 6 -0.84 -1.59 -0.13 1632.41 1.00 173 105 31 8 FALSE 1.55
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 15 16 Signature 13 0.11 -1.08 1.21 1370.23 1.00 73 12 13 3 FALSE 0.07
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 86 44 Signature 2 0.17 -0.49 0.82 1422.28 1.00 220 73 31 13 FALSE 0.22
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 55 15 Signature 3 -0.17 -1.28 0.81 1321.32 1.00 178 52 12 3 FALSE 0.13
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 269 55 Signature 4 -0.32 -0.89 0.24 1546.19 1.00 400 252 38 17 FALSE 0.58
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 156 14 Signature R2 -0.01 -0.95 0.98 1510.76 1.00 41 145 3 11 FALSE 0.01
colorectal cancer KRAS_12-61 SETD2 Any mutation 625 105 Signature overall -0.67 -1.87 0.45 1541.48 1.00 894 598 78 27 FALSE 0.60
non-small cell lung cancer KRAS_12-61 SETD2 Any mutation 581 144 Signature overall -0.03 -0.89 0.84 1454.65 1.00 912 534 97 47 FALSE 0.03
non-small cell lung cancer KRAS_12-61 PBRM1 Any mutation 84 20 Signature 2 -0.31 -1.27 0.62 1612.38 1.00 230 79 15 5 TRUE 0.28
non-small cell lung cancer KRAS_12-61 PBRM1 Any mutation 266 27 Signature 4 -0.69 -1.62 0.04 1436.90 1.00 416 260 21 6 TRUE 1.02
non-small cell lung cancer KRAS_12-61 PBRM1 Any mutation 350 47 Signature overall -0.48 -1.67 0.79 1408.90 1.00 646 339 36 11 TRUE 0.33
colorectal cancer KRAS_12-61 EPHA3 Any mutation 14 14 Signature 10 -0.06 -1.14 0.98 1384.26 1.00 18 10 10 4 FALSE 0.04
colorectal cancer KRAS_12-61 EPHA3 Any mutation 164 13 Signature 15 -0.30 -1.25 0.60 1319.82 1.00 213 159 8 5 FALSE 0.30
colorectal cancer KRAS_12-61 EPHA3 Any mutation 332 42 Signature 1A 0.15 -0.46 0.73 1350.60 1.00 492 313 23 19 FALSE 0.21
colorectal cancer KRAS_12-61 EPHA3 Any mutation 112 26 Signature 6 -0.36 -1.15 0.40 1445.12 1.00 182 105 19 7 FALSE 0.42
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 66 13 Signature 18 -0.16 -1.11 0.80 1581.29 1.00 77 61 8 5 FALSE 0.13
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 86 27 Signature 2 0.24 -0.52 1.01 1482.58 1.00 223 77 18 9 FALSE 0.26
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 55 18 Signature 3 0.49 -0.46 1.39 1677.15 1.00 179 48 11 7 FALSE 0.55
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 269 112 Signature 4 -0.15 -0.58 0.27 1434.12 1.00 370 231 74 38 FALSE 0.33
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 155 13 Signature R2 -0.26 -1.23 0.60 1463.00 1.00 40 146 4 9 FALSE 0.24
colorectal cancer KRAS_12-61 EPHA3 Any mutation 622 95 Signature overall -0.14 -1.04 0.76 1265.64 1.00 905 587 60 35 FALSE 0.11
non-small cell lung cancer KRAS_12-61 EPHA3 Any mutation 631 183 Signature overall 0.04 -0.75 0.83 1509.70 1.00 889 563 115 68 FALSE 0.03
non-small cell lung cancer KRAS_12-61 KDR Any mutation 84 12 Signature 2 0.44 -0.59 1.55 1330.31 1.00 233 79 7 5 TRUE 0.38
non-small cell lung cancer KRAS_12-61 KDR Any mutation 55 11 Signature 3 0.98 -0.20 2.15 1563.60 1.00 184 49 5 6 TRUE 0.96
non-small cell lung cancer KRAS_12-61 KDR Any mutation 267 76 Signature 4 -0.70 -1.30 -0.13 1307.58 1.00 382 250 59 17 TRUE 1.73
non-small cell lung cancer KRAS_12-61 KDR Any mutation 406 99 Signature overall 0.24 -1.06 1.55 1391.63 1.00 799 378 71 28 TRUE 0.15
colorectal cancer KRAS_12-61 PTCH1 Any mutation 12 11 Signature 10 -0.99 -2.54 0.18 1667.48 1.00 16 11 10 1 TRUE 0.83
colorectal cancer KRAS_12-61 PTCH1 Any mutation 164 14 Signature 15 -0.78 -1.73 0.13 1377.32 1.00 214 160 10 4 TRUE 0.98
colorectal cancer KRAS_12-61 PTCH1 Any mutation 334 55 Signature 1A -0.34 -0.90 0.23 1265.19 1.00 484 315 36 19 TRUE 0.61
colorectal cancer KRAS_12-61 PTCH1 Any mutation 118 53 Signature 6 -0.52 -1.15 0.05 1491.94 1.00 172 104 39 14 TRUE 1.03
colorectal cancer KRAS_12-61 PTCH1 Any mutation 628 133 Signature overall -0.66 -1.64 0.22 1592.15 1.00 886 590 95 38 TRUE 0.83
colorectal cancer KRAS_12-61 TET1 Any mutation 18 27 Signature 10 -0.50 -1.61 0.57 1150.86 1.00 13 10 19 8 FALSE 0.43
colorectal cancer KRAS_12-61 TET1 Any mutation 160 18 Signature 15 -2.05 -3.70 -0.78 1489.56 1.00 204 159 17 1 FALSE 2.28
colorectal cancer KRAS_12-61 TET1 Any mutation 320 25 Signature 1A -0.17 -0.96 0.57 1545.74 1.00 488 310 15 10 FALSE 0.18
colorectal cancer KRAS_12-61 TET1 Any mutation 108 28 Signature 6 -0.83 -1.76 -0.03 1575.16 1.00 176 102 22 6 FALSE 1.21
non-small cell lung cancer KRAS_12-61 TET1 Any mutation 84 12 Signature 2 1.02 -0.10 2.28 1354.28 1.00 233 77 5 7 FALSE 1.03
non-small cell lung cancer KRAS_12-61 TET1 Any mutation 269 60 Signature 4 -0.39 -1.00 0.20 1456.14 1.00 398 252 43 17 FALSE 0.68
colorectal cancer KRAS_12-61 TET1 Any mutation 606 98 Signature overall -0.89 -2.21 0.39 1599.98 1.00 881 581 73 25 FALSE 0.74
non-small cell lung cancer KRAS_12-61 TET1 Any mutation 353 72 Signature overall 0.29 -1.70 2.49 1457.77 1.00 631 329 48 24 FALSE 0.11
uterine cancer KRAS_12-61 FGFR2 Any mutation 39 26 Signature 1A -2.02 -4.08 -0.46 1345.20 1.00 158 38 25 1 TRUE 1.55
uterine cancer KRAS_12-61 FGFR2 Any mutation 17 22 Signature 6 -1.98 -3.98 -0.46 1254.69 1.00 63 16 21 1 TRUE 1.51
uterine cancer KRAS_12-61 FGFR2 Any mutation 56 48 Signature overall -1.98 -4.12 -0.34 1294.02 1.00 221 54 46 2 TRUE 1.40
non-small cell lung cancer KRAS_12-61 TBX3 Any mutation 266 75 Signature 4 -0.97 -1.56 -0.39 1516.40 1.00 384 251 60 15 FALSE 3.01
non-small cell lung cancer KRAS_12-61 TBX3 Any mutation 154 15 Signature R2 -0.63 -1.61 0.38 1645.09 1.00 40 144 5 10 FALSE 0.64
non-small cell lung cancer KRAS_12-61 TBX3 Any mutation 420 90 Signature overall -0.80 -2.56 1.06 1432.56 1.00 424 395 65 25 FALSE 0.42
colorectal cancer KRAS_12-61 SMAD3 Any mutation 167 21 Signature 15 0.38 -0.13 0.90 1168.02 1.00 212 156 10 11 TRUE 0.82
colorectal cancer KRAS_12-61 SMAD3 Any mutation 335 38 Signature 1A 0.35 -0.11 0.84 1230.82 1.00 496 316 19 19 TRUE 0.84
colorectal cancer KRAS_12-61 SMAD3 Any mutation 112 20 Signature 6 0.36 -0.19 0.87 1320.52 1.00 188 104 12 8 TRUE 0.76
colorectal cancer KRAS_12-61 SMAD3 Any mutation 614 79 Signature overall 0.36 -0.12 0.86 1290.13 1.00 896 576 41 38 TRUE 0.83
non-small cell lung cancer KRAS_12-61 NTRK3 Any mutation 86 15 Signature 2 1.20 0.24 2.19 1451.45 1.00 234 77 6 9 FALSE 1.77
non-small cell lung cancer KRAS_12-61 NTRK3 Any mutation 54 14 Signature 3 0.61 -0.43 1.61 1382.89 1.00 181 49 9 5 FALSE 0.61
non-small cell lung cancer KRAS_12-61 NTRK3 Any mutation 270 105 Signature 4 -0.34 -0.78 0.08 1498.79 1.00 379 239 74 31 FALSE 0.91
non-small cell lung cancer KRAS_12-61 NTRK3 Any mutation 155 18 Signature R2 0.78 -0.28 2.08 1527.08 1.00 42 139 2 16 FALSE 0.73
non-small cell lung cancer KRAS_12-61 NTRK3 Any mutation 565 152 Signature overall 0.54 -0.71 1.77 1493.03 1.00 836 504 91 61 FALSE 0.41
colorectal cancer KRAS_12-61 GRIN2A Any mutation 13 18 Signature 10 -0.53 -1.72 0.52 1558.08 1.00 15 9 14 4 FALSE 0.46
colorectal cancer KRAS_12-61 GRIN2A Any mutation 164 12 Signature 15 -0.85 -2.05 0.17 1250.17 1.00 215 161 9 3 FALSE 0.90
colorectal cancer KRAS_12-61 GRIN2A Any mutation 332 43 Signature 1A -0.49 -1.14 0.15 1485.20 1.00 484 319 30 13 FALSE 0.88
colorectal cancer KRAS_12-61 GRIN2A Any mutation 111 43 Signature 6 -0.44 -1.08 0.23 1477.50 1.00 172 99 31 12 FALSE 0.70
non-small cell lung cancer KRAS_12-61 GRIN2A Any mutation 84 15 Signature 2 -0.54 -1.78 0.58 1469.34 1.00 228 81 12 3 FALSE 0.42
non-small cell lung cancer KRAS_12-61 GRIN2A Any mutation 268 76 Signature 4 -0.66 -1.20 -0.15 1599.33 1.00 385 249 57 19 FALSE 1.81
non-small cell lung cancer KRAS_12-61 GRIN2A Any mutation 154 13 Signature R2 -0.44 -1.40 0.58 1344.85 1.00 40 145 4 9 FALSE 0.40
colorectal cancer KRAS_12-61 GRIN2A Any mutation 620 116 Signature overall -0.60 -1.66 0.37 1338.53 1.00 886 588 84 32 FALSE 0.62
non-small cell lung cancer KRAS_12-61 GRIN2A Any mutation 506 104 Signature overall -0.54 -1.87 0.74 1538.80 1.00 653 475 73 31 FALSE 0.39
uterine cancer KRAS_12-61 CTCF Any mutation 27 18 Signature 15 0.79 -0.15 1.74 1485.12 1.00 73 19 10 8 FALSE 1.03
uterine cancer KRAS_12-61 CTCF Any mutation 40 49 Signature 1A 0.79 0.11 1.49 1502.92 1.00 149 25 34 15 FALSE 1.58
uterine cancer KRAS_12-61 CTCF Any mutation 17 40 Signature 6 -0.08 -1.07 0.83 1412.35 1.00 49 12 35 5 FALSE 0.06
uterine cancer KRAS_12-61 CTCF Any mutation 86 123 Signature overall 0.45 -0.52 1.42 1398.49 1.00 295 57 94 29 FALSE 0.45
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 22 11 Signature 11 1.70 0.76 2.70 1123.06 1.00 21 12 1 10 TRUE 3.25
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 31 19 Signature 15 1.46 0.65 2.26 1408.35 1.00 97 20 8 11 TRUE 3.45
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 9 11 Signature 16 0.70 -0.39 1.71 1451.15 1.00 42 7 9 2 TRUE 0.74
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 67 38 Signature 18 0.91 0.27 1.53 1455.04 1.00 69 45 16 22 TRUE 2.23
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 17 17 Signature 19 0.84 -0.07 1.68 1424.06 1.00 35 11 11 6 TRUE 1.20
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 47 21 Signature 1A 1.69 0.91 2.51 1544.69 1.00 211 34 8 13 TRUE 4.83
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 85 55 Signature 2 0.30 -0.26 0.84 1168.32 1.00 208 70 40 15 TRUE 0.52
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 15 13 Signature 20 1.65 0.75 2.64 1304.93 1.00 57 7 5 8 TRUE 3.11
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 54 37 Signature 3 0.93 0.31 1.54 1524.85 1.00 166 40 23 14 TRUE 2.41
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 267 163 Signature 4 0.50 0.17 0.83 1481.65 1.00 349 192 88 75 TRUE 2.41
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 30 13 Signature 8 0.97 0.04 1.84 1583.75 1.00 29 22 5 8 TRUE 1.49
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 155 61 Signature R2 0.87 0.24 1.57 1509.44 1.00 34 104 10 51 TRUE 2.01
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 21 13 Signature U1 1.22 0.33 2.16 1532.65 1.00 83 15 7 6 TRUE 2.06
non-small cell lung cancer KRAS_12-61 STK11 Any mutation 820 472 Signature overall 1.05 0.60 1.49 1531.07 1.00 1401 579 231 241 TRUE 5.14
colorectal cancer KRAS_12-61 ASXL1 Any mutation 12 11 Signature 10 -1.11 -2.65 0.10 1408.24 1.00 14 11 10 1 TRUE 0.92
colorectal cancer KRAS_12-61 ASXL1 Any mutation 164 14 Signature 15 -0.78 -1.85 0.15 1492.06 1.00 213 160 10 4 TRUE 0.89
colorectal cancer KRAS_12-61 ASXL1 Any mutation 331 31 Signature 1A -0.60 -1.31 0.12 1520.74 1.00 494 322 22 9 TRUE 1.01
colorectal cancer KRAS_12-61 ASXL1 Any mutation 111 34 Signature 6 -0.52 -1.28 0.21 1529.93 1.00 180 102 25 9 TRUE 0.79
colorectal cancer KRAS_12-61 ASXL1 Any mutation 618 90 Signature overall -0.75 -1.77 0.14 1361.21 1.00 901 595 67 23 TRUE 0.89
colorectal cancer KRAS_12-61 EP300 Any mutation 165 18 Signature 15 -0.86 -1.80 -0.04 1425.84 1.00 210 161 14 4 TRUE 1.31
colorectal cancer KRAS_12-61 EP300 Any mutation 331 36 Signature 1A -0.32 -0.98 0.33 1497.85 1.00 493 318 23 13 TRUE 0.46
colorectal cancer KRAS_12-61 EP300 Any mutation 115 51 Signature 6 -0.51 -1.17 0.10 1438.45 1.00 173 102 38 13 TRUE 0.92
non-small cell lung cancer KRAS_12-61 EP300 Any mutation 14 11 Signature 13 -0.10 -1.43 1.18 1535.04 1.00 77 12 9 2 TRUE 0.06
non-small cell lung cancer KRAS_12-61 EP300 Any mutation 85 20 Signature 2 -0.53 -1.59 0.33 1543.99 1.00 228 82 17 3 TRUE 0.54
non-small cell lung cancer KRAS_12-61 EP300 Any mutation 267 30 Signature 4 -0.18 -0.88 0.49 1468.13 1.00 417 256 19 11 TRUE 0.22
uterine cancer KRAS_12-61 EP300 Any mutation 40 21 Signature 1A 0.23 -0.84 1.22 1602.78 1.00 164 35 16 5 TRUE 0.18
uterine cancer KRAS_12-61 EP300 Any mutation 17 20 Signature 6 0.16 -1.14 1.25 1486.30 1.00 67 13 16 4 TRUE 0.11
colorectal cancer KRAS_12-61 EP300 Any mutation 611 105 Signature overall -0.56 -1.48 0.29 1337.04 1.00 876 581 75 30 TRUE 0.65
non-small cell lung cancer KRAS_12-61 EP300 Any mutation 366 61 Signature overall -0.25 -1.25 0.79 1305.12 1.00 722 350 45 16 TRUE 0.20
uterine cancer KRAS_12-61 EP300 Any mutation 60 74 Signature overall 0.14 -1.38 1.82 1593.14 1.00 251 49 63 11 TRUE 0.07
colorectal cancer KRAS_12-61 ERBB4 Any mutation 16 18 Signature 10 0.09 -0.99 1.07 1386.18 1.00 15 10 12 6 TRUE 0.06
colorectal cancer KRAS_12-61 ERBB4 Any mutation 165 23 Signature 15 -0.30 -1.09 0.42 1482.05 1.00 208 157 15 8 TRUE 0.36
colorectal cancer KRAS_12-61 ERBB4 Any mutation 332 43 Signature 1A 0.11 -0.44 0.67 1514.30 1.00 492 313 24 19 TRUE 0.16
colorectal cancer KRAS_12-61 ERBB4 Any mutation 113 31 Signature 6 0.32 -0.39 1.01 1519.99 1.00 185 99 17 14 TRUE 0.45
non-small cell lung cancer KRAS_12-61 ERBB4 Any mutation 47 11 Signature 1A -0.02 -1.21 1.10 1439.96 1.00 211 44 8 3 TRUE 0.01
non-small cell lung cancer KRAS_12-61 ERBB4 Any mutation 84 17 Signature 2 -0.75 -1.98 0.28 1572.37 1.00 228 82 15 2 TRUE 0.73
non-small cell lung cancer KRAS_12-61 ERBB4 Any mutation 270 97 Signature 4 -0.31 -0.76 0.14 1529.36 1.00 384 240 67 30 TRUE 0.73
colorectal cancer KRAS_12-61 ERBB4 Any mutation 626 115 Signature overall 0.04 -0.86 0.91 1578.22 1.00 900 579 68 47 TRUE 0.03
non-small cell lung cancer KRAS_12-61 ERBB4 Any mutation 401 125 Signature overall -0.35 -1.50 0.85 1488.52 1.00 823 366 90 35 TRUE 0.26
colorectal cancer KRAS_12-61 MED12 Any mutation 164 11 Signature 15 -0.91 -2.20 0.11 1425.24 1.00 213 162 9 2 TRUE 0.90
colorectal cancer KRAS_12-61 MED12 Any mutation 332 34 Signature 1A 0.22 -0.39 0.86 1280.16 1.00 499 315 17 17 TRUE 0.31
colorectal cancer KRAS_12-61 MED12 Any mutation 115 42 Signature 6 -0.42 -1.10 0.20 1552.28 1.00 176 104 31 11 TRUE 0.67
non-small cell lung cancer KRAS_12-61 MED12 Any mutation 84 25 Signature 2 -0.39 -1.21 0.52 1482.90 1.00 222 78 19 6 TRUE 0.43
non-small cell lung cancer KRAS_12-61 MED12 Any mutation 268 72 Signature 4 -0.67 -1.24 -0.15 1516.82 1.00 389 251 55 17 TRUE 1.84
uterine cancer KRAS_12-61 MED12 Any mutation 26 13 Signature 15 -0.40 -1.81 0.84 1270.83 1.00 72 23 10 3 TRUE 0.26
uterine cancer KRAS_12-61 MED12 Any mutation 39 18 Signature 1A -1.35 -3.13 0.10 1593.98 1.00 164 38 17 1 TRUE 1.00
uterine cancer KRAS_12-61 MED12 Any mutation 17 14 Signature 6 -1.15 -3.05 0.40 1449.36 1.00 71 16 13 1 TRUE 0.72
colorectal cancer KRAS_12-61 MED12 Any mutation 611 87 Signature overall -0.36 -1.49 0.71 1471.46 1.00 888 581 57 30 TRUE 0.28
non-small cell lung cancer KRAS_12-61 MED12 Any mutation 352 97 Signature overall -0.49 -1.47 0.64 1488.02 1.00 611 329 74 23 TRUE 0.42
uterine cancer KRAS_12-61 MED12 Any mutation 85 87 Signature overall -0.89 -2.42 0.60 1486.32 1.00 324 78 80 7 TRUE 0.62
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 14 11 Signature 13 0.71 -0.31 1.67 1319.04 1.00 77 11 8 3 FALSE 0.79
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 32 11 Signature 15 0.81 -0.10 1.75 1437.18 1.00 100 27 6 5 FALSE 1.08
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 67 17 Signature 18 0.53 -0.25 1.30 1590.35 1.00 76 58 8 9 FALSE 0.76
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 47 21 Signature 1A 0.75 -0.05 1.56 1578.11 1.00 205 40 14 7 FALSE 1.16
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 84 32 Signature 2 0.91 0.29 1.55 1520.09 1.00 223 69 17 15 FALSE 2.32
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 56 30 Signature 3 0.49 -0.26 1.19 1415.13 1.00 169 47 21 9 FALSE 0.73
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 271 128 Signature 4 0.70 0.31 1.07 1389.14 1.00 380 205 62 66 FALSE 3.68
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 154 20 Signature R2 0.41 -0.37 1.20 1346.72 1.00 40 138 4 16 FALSE 0.53
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 21 15 Signature U1 0.77 -0.11 1.68 1540.03 1.00 81 16 10 5 FALSE 1.08
non-small cell lung cancer KRAS_12-61 RBM10 Any mutation 746 285 Signature overall 0.67 0.12 1.23 1452.39 1.00 1351 611 150 135 FALSE 1.83
colorectal cancer KRAS_12-61 NF1 Any mutation 15 24 Signature 10 -0.87 -2.07 0.16 1473.21 1.00 14 10 19 5 TRUE 0.88
colorectal cancer KRAS_12-61 NF1 Any mutation 164 21 Signature 15 -1.49 -2.71 -0.48 1490.62 1.00 207 161 18 3 TRUE 2.10
colorectal cancer KRAS_12-61 NF1 Any mutation 333 40 Signature 1A -0.12 -0.75 0.52 1496.33 1.00 493 317 24 16 TRUE 0.15
colorectal cancer KRAS_12-61 NF1 Any mutation 111 44 Signature 6 -1.49 -2.48 -0.66 1462.21 1.00 172 106 39 5 TRUE 2.98
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 66 13 Signature 18 -0.27 -1.24 0.67 1520.84 1.00 78 60 7 6 TRUE 0.25
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 47 13 Signature 1A -0.63 -1.80 0.43 1407.23 1.00 208 45 11 2 TRUE 0.57
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 86 39 Signature 2 -0.49 -1.25 0.24 1379.80 1.00 212 78 31 8 TRUE 0.72
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 15 13 Signature 20 -0.94 -2.26 0.27 1466.75 1.00 51 14 12 1 TRUE 0.84
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 54 15 Signature 3 -1.09 -2.28 0.03 1482.99 1.00 176 53 14 1 TRUE 1.17
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 268 113 Signature 4 -0.72 -1.18 -0.28 1468.67 1.00 373 241 86 27 TRUE 2.79
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 24 11 Signature 7 -1.32 -2.83 -0.07 1374.43 1.00 73 24 11 0 TRUE 1.25
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 155 12 Signature R2 -0.67 -1.53 0.24 1450.77 1.00 40 147 4 8 TRUE 0.83
uterine cancer KRAS_12-61 NF1 Any mutation 39 21 Signature 1A -0.36 -1.73 0.78 1378.95 1.00 167 36 18 3 TRUE 0.25
uterine cancer KRAS_12-61 NF1 Any mutation 17 24 Signature 6 -0.43 -1.81 0.78 1367.91 1.00 64 14 21 3 TRUE 0.28
colorectal cancer KRAS_12-61 NF1 Any mutation 623 129 Signature overall -0.97 -2.16 0.24 1732.86 1.00 886 594 100 29 TRUE 0.97
non-small cell lung cancer KRAS_12-61 NF1 Any mutation 715 229 Signature overall -0.77 -1.49 -0.11 1445.51 1.00 1211 662 176 53 TRUE 1.57
uterine cancer KRAS_12-61 NF1 Any mutation 59 92 Signature overall -0.14 -2.11 2.14 1289.64 1.00 249 50 83 9 TRUE 0.05
non-small cell lung cancer KRAS_12-61 FLT1 Any mutation 67 13 Signature 18 0.50 -0.34 1.46 1409.66 1.00 79 59 5 8 FALSE 0.58
non-small cell lung cancer KRAS_12-61 FLT1 Any mutation 84 12 Signature 2 0.33 -0.54 1.28 1427.70 1.00 233 79 7 5 FALSE 0.32
non-small cell lung cancer KRAS_12-61 FLT1 Any mutation 269 64 Signature 4 -0.09 -0.63 0.42 1424.67 1.00 400 248 43 21 FALSE 0.13
non-small cell lung cancer KRAS_12-61 FLT1 Any mutation 420 89 Signature overall 0.24 -0.63 1.12 1431.97 1.00 712 386 55 34 FALSE 0.23
uterine cancer KRAS_12-61 RASA1 Any mutation 39 20 Signature 1A -1.99 -4.49 -0.23 1544.86 1.00 166 38 19 1 FALSE 1.19
uterine cancer KRAS_12-61 RASA1 Any mutation 17 12 Signature 6 -1.68 -4.25 0.37 1439.28 1.00 71 16 11 1 FALSE 0.84
uterine cancer KRAS_12-61 RASA1 Any mutation 58 78 Signature overall -2.17 -4.80 0.26 1384.34 1.00 253 56 76 2 FALSE 1.06
colorectal cancer KRAS_12-61 EPHA5 Any mutation 15 26 Signature 10 -1.30 -2.52 -0.14 1588.44 1.00 12 11 22 4 FALSE 1.50
colorectal cancer KRAS_12-61 EPHA5 Any mutation 164 18 Signature 15 -1.09 -2.21 -0.07 1558.63 1.00 211 160 14 4 FALSE 1.35
colorectal cancer KRAS_12-61 EPHA5 Any mutation 332 49 Signature 1A -0.23 -0.80 0.35 1491.99 1.00 484 314 31 18 FALSE 0.35
colorectal cancer KRAS_12-61 EPHA5 Any mutation 111 36 Signature 6 -1.53 -2.63 -0.65 1377.90 1.00 173 107 32 4 FALSE 2.62
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 67 24 Signature 18 0.16 -0.63 0.92 1453.91 1.00 72 56 13 11 FALSE 0.16
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 84 30 Signature 2 0.28 -0.49 1.01 1367.23 1.00 223 74 20 10 FALSE 0.34
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 54 19 Signature 3 0.67 -0.16 1.55 1411.20 1.00 181 46 11 8 FALSE 0.91
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 269 109 Signature 4 0.03 -0.39 0.44 1434.17 1.00 380 228 68 41 FALSE 0.05
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 154 12 Signature R2 -0.29 -1.28 0.67 1420.81 1.00 41 146 4 8 FALSE 0.26
colorectal cancer KRAS_12-61 EPHA5 Any mutation 622 129 Signature overall -1.02 -2.30 0.14 1563.50 1.00 880 592 99 30 FALSE 1.02
non-small cell lung cancer KRAS_12-61 EPHA5 Any mutation 628 194 Signature overall 0.17 -0.65 0.97 1571.37 1.00 897 550 116 78 FALSE 0.16
colorectal cancer KRAS_12-61 AR Any mutation 165 21 Signature 15 -0.63 -1.43 0.09 1218.82 1.00 209 159 15 6 TRUE 1.04
colorectal cancer KRAS_12-61 AR Any mutation 331 33 Signature 1A -0.55 -1.17 0.08 1520.76 1.00 491 321 23 10 TRUE 1.09
colorectal cancer KRAS_12-61 AR Any mutation 111 37 Signature 6 -0.53 -1.26 0.11 1278.42 1.00 177 102 28 9 TRUE 0.90
non-small cell lung cancer KRAS_12-61 AR Any mutation 268 56 Signature 4 -0.37 -0.98 0.21 1160.68 1.00 402 251 39 17 TRUE 0.66
colorectal cancer KRAS_12-61 AR Any mutation 607 91 Signature overall -0.57 -1.30 0.17 1280.45 1.00 877 582 66 25 TRUE 0.91
non-small cell lung cancer KRAS_12-61 AR Any mutation 268 56 Signature overall -0.29 -4.92 4.32 1616.67 1.00 402 251 39 17 TRUE 0.05
colorectal cancer KRAS_12-61 ROS1 Any mutation 18 30 Signature 10 -0.59 -1.69 0.42 1566.28 1.00 13 10 22 8 TRUE 0.56
colorectal cancer KRAS_12-61 ROS1 Any mutation 331 28 Signature 1A -0.75 -1.60 0.06 1408.07 1.00 495 324 21 7 TRUE 1.07
colorectal cancer KRAS_12-61 ROS1 Any mutation 111 26 Signature 6 -0.73 -1.69 0.12 1506.00 1.00 180 105 20 6 TRUE 0.91
non-small cell lung cancer KRAS_12-61 ROS1 Any mutation 84 14 Signature 2 -1.70 -3.29 -0.42 1456.91 1.00 228 83 13 1 TRUE 1.70
non-small cell lung cancer KRAS_12-61 ROS1 Any mutation 266 42 Signature 4 -1.63 -2.64 -0.82 1448.56 1.00 401 261 37 5 TRUE 3.32
colorectal cancer KRAS_12-61 ROS1 Any mutation 460 84 Signature overall -0.67 -2.30 1.02 1531.05 1.00 688 439 63 21 TRUE 0.35
non-small cell lung cancer KRAS_12-61 ROS1 Any mutation 350 56 Signature overall -1.64 -3.16 -0.22 1549.83 1.00 629 344 50 6 TRUE 1.63
colorectal cancer KRAS_12-61 PIK3CG Any mutation 15 22 Signature 10 -0.37 -1.52 0.73 1612.23 1.00 13 9 16 6 FALSE 0.28
colorectal cancer KRAS_12-61 PIK3CG Any mutation 164 17 Signature 15 -0.45 -1.37 0.43 1382.55 1.00 212 158 11 6 FALSE 0.47
colorectal cancer KRAS_12-61 PIK3CG Any mutation 331 29 Signature 1A -0.61 -1.37 0.08 1509.47 1.00 493 323 21 8 FALSE 0.95
colorectal cancer KRAS_12-61 PIK3CG Any mutation 112 29 Signature 6 -0.30 -1.11 0.42 1421.15 1.00 182 103 20 9 FALSE 0.35
non-small cell lung cancer KRAS_12-61 PIK3CG Any mutation 14 13 Signature 13 -0.74 -2.56 0.75 1750.26 1.00 73 13 12 1 FALSE 0.42
non-small cell lung cancer KRAS_12-61 PIK3CG Any mutation 86 18 Signature 2 0.98 0.09 1.89 1444.69 1.00 232 76 8 10 FALSE 1.46
non-small cell lung cancer KRAS_12-61 PIK3CG Any mutation 267 75 Signature 4 -0.41 -0.96 0.11 1632.69 1.00 389 245 53 22 FALSE 0.96
non-small cell lung cancer KRAS_12-61 PIK3CG Any mutation 154 12 Signature R2 -1.34 -2.50 -0.26 1441.77 1.00 38 149 7 5 FALSE 1.70
colorectal cancer KRAS_12-61 PIK3CG Any mutation 622 97 Signature overall -0.44 -1.61 0.72 1599.30 1.00 900 593 68 29 FALSE 0.35
non-small cell lung cancer KRAS_12-61 PIK3CG Any mutation 521 118 Signature overall -0.36 -1.69 0.99 1355.54 1.00 732 483 80 38 FALSE 0.22
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 14 23 Signature 13 -3.08 -4.06 -2.08 1412.44 1.00 64 13 22 1 TRUE 8.95
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 21 12 Signature 14 -3.09 -4.14 -2.04 1451.68 1.00 26 20 11 1 TRUE 8.43
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 32 54 Signature 15 -3.06 -3.99 -2.21 1283.88 1.00 61 30 52 2 TRUE 10.47
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 9 19 Signature 16 -3.30 -4.36 -2.32 1425.02 1.00 33 9 19 0 TRUE 9.09
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 19 21 Signature 17 -3.17 -4.23 -2.18 1416.10 1.00 13 18 20 1 TRUE 8.92
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 66 29 Signature 18 -3.46 -4.47 -2.57 1541.23 1.00 59 66 29 0 TRUE 11.73
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 16 16 Signature 19 -3.30 -4.38 -2.32 1637.15 1.00 31 16 16 0 TRUE 9.15
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 47 197 Signature 1A -3.74 -4.73 -2.89 1430.48 1.00 94 47 197 0 TRUE 15.17
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 84 79 Signature 2 -3.33 -4.30 -2.47 1432.91 1.00 178 83 78 1 TRUE 11.78
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 15 35 Signature 20 -3.34 -4.30 -2.38 1569.78 1.00 34 15 35 0 TRUE 10.11
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 11 29 Signature 21 -3.33 -4.40 -2.33 1499.78 1.00 29 11 29 0 TRUE 9.38
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 54 89 Signature 3 -2.87 -3.68 -2.06 1587.46 1.00 112 50 85 4 TRUE 11.32
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 266 114 Signature 4 -2.62 -3.33 -1.99 1357.61 1.00 352 257 105 9 TRUE 14.15
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 13 18 Signature 6 -3.07 -4.06 -2.02 1462.94 1.00 28 12 17 1 TRUE 8.63
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 24 34 Signature 7 -3.36 -4.42 -2.38 1510.96 1.00 54 24 34 0 TRUE 9.85
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 29 14 Signature 8 -3.17 -4.22 -2.16 1542.35 1.00 22 28 13 1 TRUE 9.03
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 7 11 Signature R3 -3.25 -4.32 -2.19 1540.17 1.00 14 7 11 0 TRUE 8.65
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 21 46 Signature U1 -3.39 -4.46 -2.49 1420.68 1.00 49 21 46 0 TRUE 10.83
non-small cell lung cancer KRAS_12-61 EGFR Any mutation 751 853 Signature overall -3.22 -3.75 -2.69 1479.02 1.00 1268 730 832 21 TRUE 30.91
colorectal cancer KRAS_12-61 ARID1B Any mutation 164 22 Signature 15 -1.01 -1.79 -0.22 1460.67 1.00 209 158 16 6 TRUE 2.01
colorectal cancer KRAS_12-61 ARID1B Any mutation 332 53 Signature 1A -0.99 -1.59 -0.39 1527.49 1.00 481 320 41 12 TRUE 2.86
colorectal cancer KRAS_12-61 ARID1B Any mutation 111 46 Signature 6 -1.48 -2.35 -0.77 1181.65 1.00 166 107 42 4 TRUE 3.50
non-small cell lung cancer KRAS_12-61 ARID1B Any mutation 84 13 Signature 2 0.13 -0.96 1.29 1377.18 1.00 232 79 8 5 TRUE 0.08
non-small cell lung cancer KRAS_12-61 ARID1B Any mutation 266 42 Signature 4 -0.72 -1.45 -0.04 1285.69 1.00 405 257 33 9 TRUE 1.30
uterine cancer KRAS_12-61 ARID1B Any mutation 39 17 Signature 1A 0.26 -0.89 1.31 1434.02 1.00 168 35 13 4 TRUE 0.19
uterine cancer KRAS_12-61 ARID1B Any mutation 18 39 Signature 6 -0.05 -1.08 0.95 1606.00 1.00 55 12 33 6 TRUE 0.03
colorectal cancer KRAS_12-61 ARID1B Any mutation 607 121 Signature overall -1.18 -1.91 -0.43 1508.35 1.00 856 585 99 22 TRUE 2.61
non-small cell lung cancer KRAS_12-61 ARID1B Any mutation 350 55 Signature overall -0.29 -1.82 1.34 1527.57 1.00 637 336 41 14 TRUE 0.15
uterine cancer KRAS_12-61 ARID1B Any mutation 59 78 Signature overall 0.28 -1.50 2.22 1484.45 1.00 250 47 66 12 TRUE 0.12
non-small cell lung cancer KRAS_12-61 MET Any mutation 84 23 Signature 2 -0.89 -1.96 -0.03 1236.77 1.00 222 82 21 2 TRUE 1.16
non-small cell lung cancer KRAS_12-61 MET Any mutation 54 11 Signature 3 -0.64 -1.70 0.32 1711.37 1.00 181 52 9 2 TRUE 0.66
non-small cell lung cancer KRAS_12-61 MET Any mutation 266 34 Signature 4 -0.54 -1.23 0.13 1451.35 1.00 416 256 24 10 TRUE 0.93
non-small cell lung cancer KRAS_12-61 MET Any mutation 404 68 Signature overall -0.68 -1.54 0.22 1442.34 1.00 819 390 54 14 TRUE 0.91
colorectal cancer KRAS_12-61 BRAF Any mutation 164 48 Signature 15 -2.24 -2.98 -1.54 1724.17 1.00 180 159 43 5 TRUE 10.01
colorectal cancer KRAS_12-61 BRAF Any mutation 332 99 Signature 1A -2.13 -2.71 -1.51 101.13 1.03 428 321 88 11 TRUE 11.72
colorectal cancer KRAS_12-61 BRAF Any mutation 111 60 Signature 6 -2.70 -4.62 -1.90 101.96 1.03 146 111 60 0 TRUE 3.85
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 66 11 Signature 18 -1.22 -2.30 -0.35 1503.21 1.00 74 65 10 1 TRUE 1.84
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 84 20 Signature 2 -1.10 -2.07 -0.26 1612.86 1.00 222 82 18 2 TRUE 1.84
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 54 20 Signature 3 -1.07 -2.05 -0.22 1527.19 1.00 171 52 18 2 TRUE 1.73
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 266 50 Signature 4 -0.80 -1.40 -0.22 1384.06 1.00 401 253 37 13 TRUE 2.04
colorectal cancer KRAS_12-61 BRAF Any mutation 607 207 Signature overall -2.36 -3.32 -1.68 1516.13 1.00 754 591 191 16 TRUE 7.73
non-small cell lung cancer KRAS_12-61 BRAF Any mutation 470 101 Signature overall -1.05 -1.80 -0.35 1399.30 1.00 868 452 83 18 TRUE 2.36
colorectal cancer KRAS_12-61 B2M Any mutation 13 14 Signature 10 -0.84 -2.17 0.26 1268.74 1.00 16 11 12 2 FALSE 0.77
colorectal cancer KRAS_12-61 B2M Any mutation 162 20 Signature 15 -0.85 -1.79 -0.01 1560.06 1.00 207 157 15 5 FALSE 1.25
colorectal cancer KRAS_12-61 B2M Any mutation 324 46 Signature 1A -0.40 -0.99 0.16 1445.21 1.00 484 309 31 15 FALSE 0.75
colorectal cancer KRAS_12-61 B2M Any mutation 114 51 Signature 6 -0.47 -1.14 0.14 1600.45 1.00 170 100 37 14 FALSE 0.86
colorectal cancer KRAS_12-61 B2M Any mutation 613 131 Signature overall -0.65 -1.52 0.20 1490.49 1.00 877 577 95 36 FALSE 0.85
colorectal cancer KRAS_12-61 CARD11 Any mutation 164 14 Signature 15 -0.39 -1.23 0.38 1525.58 1.00 212 159 9 5 FALSE 0.50
colorectal cancer KRAS_12-61 CARD11 Any mutation 334 58 Signature 1A -0.05 -0.54 0.48 1311.28 1.00 482 310 34 24 FALSE 0.07
colorectal cancer KRAS_12-61 CARD11 Any mutation 113 38 Signature 6 -0.43 -1.17 0.22 1343.23 1.00 177 104 29 9 FALSE 0.65
non-small cell lung cancer KRAS_12-61 CARD11 Any mutation 86 16 Signature 2 0.47 -0.40 1.48 1499.97 1.00 231 79 9 7 FALSE 0.49
non-small cell lung cancer KRAS_12-61 CARD11 Any mutation 266 63 Signature 4 -0.04 -0.59 0.50 1528.29 1.00 399 244 41 22 FALSE 0.06
colorectal cancer KRAS_12-61 CARD11 Any mutation 611 110 Signature overall -0.29 -1.03 0.46 1299.75 1.00 871 573 72 38 FALSE 0.35
non-small cell lung cancer KRAS_12-61 CARD11 Any mutation 352 79 Signature overall 0.19 -1.11 1.54 1611.98 1.00 630 323 50 29 FALSE 0.11
non-small cell lung cancer KRAS_12-61 INPP4B Any mutation 85 15 Signature 2 0.83 -0.11 1.93 1493.79 1.00 234 77 7 8 FALSE 0.98
non-small cell lung cancer KRAS_12-61 INPP4B Any mutation 268 60 Signature 4 0.12 -0.40 0.67 1209.04 1.00 405 245 37 23 FALSE 0.18
non-small cell lung cancer KRAS_12-61 INPP4B Any mutation 353 75 Signature overall 0.48 -0.87 2.02 1619.75 1.00 639 322 44 31 FALSE 0.28
non-small cell lung cancer KRAS_12-61 NFE2L2 Any mutation 14 15 Signature 13 -0.80 -2.39 0.53 1331.49 1.00 73 13 14 1 FALSE 0.56
non-small cell lung cancer KRAS_12-61 NFE2L2 Any mutation 84 32 Signature 2 -0.67 -1.59 0.18 1557.12 1.00 220 79 27 5 FALSE 0.84
non-small cell lung cancer KRAS_12-61 NFE2L2 Any mutation 267 20 Signature 4 -0.35 -1.23 0.46 1549.79 1.00 423 260 13 7 FALSE 0.37
non-small cell lung cancer KRAS_12-61 NFE2L2 Any mutation 365 67 Signature overall -0.60 -1.82 0.62 1490.13 1.00 716 352 54 13 FALSE 0.47
colorectal cancer KRAS_12-61 SOX9 Any mutation 166 40 Signature 15 0.47 -0.02 1.06 1427.78 1.00 205 142 16 24 FALSE 1.05
colorectal cancer KRAS_12-61 SOX9 Any mutation 336 105 Signature 1A 0.37 0.01 0.75 1376.79 1.00 464 285 54 51 FALSE 1.36
colorectal cancer KRAS_12-61 SOX9 Any mutation 113 59 Signature 6 0.11 -0.42 0.59 1352.89 1.00 165 94 40 19 FALSE 0.17
colorectal cancer KRAS_12-61 SOX9 Any mutation 615 204 Signature overall 0.32 -0.24 0.87 1496.90 1.00 834 521 110 94 FALSE 0.60
colorectal cancer KRAS_12-61 SMAD2 Any mutation 164 16 Signature 15 0.55 -0.04 1.05 565.23 1.01 213 156 8 8 TRUE 1.28
colorectal cancer KRAS_12-61 SMAD2 Any mutation 334 33 Signature 1A 0.65 0.12 1.18 1383.28 1.00 504 313 12 21 TRUE 1.83
colorectal cancer KRAS_12-61 SMAD2 Any mutation 111 17 Signature 6 0.54 -0.11 1.06 642.08 1.01 191 105 11 6 TRUE 1.18
colorectal cancer KRAS_12-61 SMAD2 Any mutation 609 66 Signature overall 0.59 0.02 1.08 982.77 1.01 908 574 31 35 TRUE 1.56
non-small cell lung cancer KRAS_12-61 GLI1 Any mutation 251 44 Signature 4 0.19 -0.44 0.78 97.20 1.03 361 232 25 19 FALSE 0.25
non-small cell lung cancer KRAS_12-61 GLI1 Any mutation 251 44 Signature overall 0.18 -4.12 4.59 1484.80 1.00 361 232 25 19 FALSE 0.03
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 16 17 Signature 10 -0.40 -1.40 0.56 1522.30 1.00 11 10 11 6 FALSE 0.39
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 149 31 Signature 15 -0.83 -1.57 -0.12 1458.17 1.00 187 141 23 8 FALSE 1.58
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 315 80 Signature 1A -0.70 -1.16 -0.22 1353.63 1.00 435 294 59 21 FALSE 2.31
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 105 81 Signature 6 -0.85 -1.44 -0.30 1411.51 1.00 146 89 65 16 FALSE 2.42
non-small cell lung cancer KRAS_12-61 ZFHX3 Any mutation 79 18 Signature 2 -0.52 -1.76 0.53 1464.12 1.00 197 75 14 4 FALSE 0.44
non-small cell lung cancer KRAS_12-61 ZFHX3 Any mutation 251 61 Signature 4 -0.36 -0.95 0.17 1429.84 1.00 346 231 41 20 FALSE 0.70
non-small cell lung cancer KRAS_12-61 ZFHX3 Any mutation 138 14 Signature R2 -1.35 -2.55 -0.34 1485.05 1.00 31 132 8 6 FALSE 1.75
uterine cancer KRAS_12-61 ZFHX3 Any mutation 6 21 Signature 14 0.20 -1.21 1.56 1531.79 1.00 6 2 17 4 FALSE 0.11
uterine cancer KRAS_12-61 ZFHX3 Any mutation 25 13 Signature 15 0.74 -0.33 1.80 1388.22 1.00 71 19 7 6 FALSE 0.74
uterine cancer KRAS_12-61 ZFHX3 Any mutation 41 56 Signature 1A 0.42 -0.30 1.11 1568.53 1.00 131 27 42 14 FALSE 0.64
uterine cancer KRAS_12-61 ZFHX3 Any mutation 17 45 Signature 6 0.18 -0.77 1.09 1352.54 1.00 48 9 37 8 FALSE 0.15
colorectal cancer KRAS_12-61 ZFHX3 Any mutation 585 209 Signature overall -0.71 -1.51 0.06 1480.11 1.00 779 534 158 51 FALSE 1.14
non-small cell lung cancer KRAS_12-61 ZFHX3 Any mutation 468 93 Signature overall -0.75 -2.12 0.71 1383.26 1.00 574 438 63 30 FALSE 0.55
uterine cancer KRAS_12-61 ZFHX3 Any mutation 93 184 Signature overall 0.32 -0.77 1.45 1373.84 1.00 275 58 149 35 FALSE 0.25
colorectal cancer KRAS_12-61 MGA Any mutation 16 15 Signature 10 -0.27 -1.39 0.79 1344.21 1.00 12 11 10 5 FALSE 0.20
colorectal cancer KRAS_12-61 MGA Any mutation 147 16 Signature 15 -0.60 -1.53 0.28 1493.29 1.00 190 142 11 5 FALSE 0.71
colorectal cancer KRAS_12-61 MGA Any mutation 313 42 Signature 1A -0.10 -0.75 0.48 1486.93 1.00 455 296 25 17 FALSE 0.13
colorectal cancer KRAS_12-61 MGA Any mutation 103 36 Signature 6 -0.80 -1.65 -0.07 1614.80 1.00 161 96 29 7 FALSE 1.36
non-small cell lung cancer KRAS_12-61 MGA Any mutation 79 28 Signature 2 -0.73 -1.75 0.17 1785.40 1.00 198 75 24 4 FALSE 0.85
non-small cell lung cancer KRAS_12-61 MGA Any mutation 252 79 Signature 4 -0.19 -0.68 0.30 1386.27 1.00 338 224 51 28 FALSE 0.36
non-small cell lung cancer KRAS_12-61 MGA Any mutation 138 13 Signature R2 0.13 -0.97 1.32 1553.03 1.00 37 127 2 11 FALSE 0.09
uterine cancer KRAS_12-61 MGA Any mutation 6 49 Signature 10 1.16 -0.61 4.06 1486.98 1.00 20 0 43 6 FALSE 0.49
uterine cancer KRAS_12-61 MGA Any mutation 36 19 Signature 1A -0.28 -1.57 0.85 1616.05 1.00 152 33 16 3 FALSE 0.18
uterine cancer KRAS_12-61 MGA Any mutation 16 14 Signature 6 -0.96 -3.04 0.60 1597.59 1.00 63 15 13 1 FALSE 0.52
colorectal cancer KRAS_12-61 MGA Any mutation 579 109 Signature overall -0.45 -1.48 0.42 1326.56 1.00 818 545 75 34 FALSE 0.44
non-small cell lung cancer KRAS_12-61 MGA Any mutation 469 120 Signature overall -0.24 -1.52 1.05 1490.73 1.00 573 426 77 43 FALSE 0.15
uterine cancer KRAS_12-61 MGA Any mutation 58 82 Signature overall 0.01 -2.07 2.34 1641.95 1.00 235 48 72 10 FALSE 0.00
colorectal cancer KRAS_12-61 KMT2B Any mutation 85 18 Signature 15 -0.78 -1.72 0.09 1611.48 1.00 101 80 13 5 FALSE 1.05
colorectal cancer KRAS_12-61 KMT2B Any mutation 190 64 Signature 1A -0.45 -0.98 0.08 1400.92 1.00 239 169 43 21 FALSE 0.99
colorectal cancer KRAS_12-61 KMT2B Any mutation 68 86 Signature 6 -0.72 -1.34 -0.16 1282.71 1.00 73 48 66 20 FALSE 1.80
uterine cancer KRAS_12-61 KMT2B Any mutation 20 15 Signature 15 0.57 -0.35 1.52 1415.60 1.00 42 13 8 7 FALSE 0.62
uterine cancer KRAS_12-61 KMT2B Any mutation 36 51 Signature 1A 0.43 -0.30 1.09 1468.80 1.00 100 22 37 14 FALSE 0.66
uterine cancer KRAS_12-61 KMT2B Any mutation 7 13 Signature 20 -0.09 -1.43 1.01 1637.21 1.00 14 5 11 2 FALSE 0.05
uterine cancer KRAS_12-61 KMT2B Any mutation 13 39 Signature 6 0.61 -0.29 1.61 1577.62 1.00 40 4 30 9 FALSE 0.67
colorectal cancer KRAS_12-61 KMT2B Any mutation 343 168 Signature overall -0.64 -1.63 0.38 1552.73 1.00 413 297 122 46 FALSE 0.67
uterine cancer KRAS_12-61 KMT2B Any mutation 81 152 Signature overall 0.19 -0.68 1.02 1551.73 1.00 215 47 118 34 FALSE 0.18
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 150 48 Signature 15 0.09 -0.38 0.61 1499.34 1.00 176 128 26 22 FALSE 0.14
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 319 115 Signature 1A 0.08 -0.28 0.44 1453.38 1.00 416 271 67 48 FALSE 0.17
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 41 12 Signature 2 0.53 -0.16 1.47 1374.69 1.00 30 30 1 11 FALSE 0.66
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 105 69 Signature 6 -0.19 -0.77 0.31 1510.89 1.00 142 86 50 19 FALSE 0.31
colorectal cancer KRAS_12-61 TCF7L2 Any mutation 615 244 Signature overall 0.12 -0.39 0.70 1535.80 1.00 764 515 144 100 FALSE 0.17
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 14 12 Signature 10 -0.46 -1.52 0.55 1575.46 1.00 13 10 8 4 FALSE 0.41
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 143 17 Signature 15 -0.93 -1.79 -0.09 1474.88 1.00 187 139 13 4 FALSE 1.40
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 302 47 Signature 1A -0.82 -1.50 -0.21 1609.75 1.00 436 291 36 11 FALSE 1.98
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 102 57 Signature 6 -0.78 -1.42 -0.20 1412.31 1.00 150 90 45 12 FALSE 1.89
colorectal cancer KRAS_12-61 ANKRD11 Any mutation 561 133 Signature overall -0.75 -1.64 0.12 1492.50 1.00 786 530 102 31 FALSE 1.07
colorectal cancer KRAS_12-61 POLD1 Any mutation 147 15 Signature 15 -1.37 -2.68 -0.39 1402.73 1.00 193 145 13 2 TRUE 1.76
colorectal cancer KRAS_12-61 POLD1 Any mutation 315 43 Signature 1A -0.33 -0.98 0.33 1336.99 1.00 455 299 27 16 TRUE 0.51
colorectal cancer KRAS_12-61 POLD1 Any mutation 103 44 Signature 6 -1.37 -2.30 -0.56 1606.66 1.00 158 98 39 5 TRUE 2.73
colorectal cancer KRAS_12-61 POLD1 Any mutation 565 102 Signature overall -1.03 -2.13 0.01 1510.08 1.00 806 542 79 23 TRUE 1.25
non-small cell lung cancer KRAS_12-61 PREX2 Any mutation 148 52 Signature 4 -0.27 -0.87 0.30 643.36 1.01 188 130 34 18 FALSE 0.40
non-small cell lung cancer KRAS_12-61 PREX2 Any mutation 148 52 Signature overall -0.26 -4.22 3.85 1369.76 1.00 188 130 34 18 FALSE 0.05
colorectal cancer KRAS_12-61 AMER1 Any mutation 164 34 Signature 15 0.66 0.17 1.10 1135.04 1.00 207 145 15 19 FALSE 2.32
colorectal cancer KRAS_12-61 AMER1 Any mutation 335 61 Signature 1A 0.66 0.24 1.09 1102.79 1.00 490 300 26 35 FALSE 2.81
colorectal cancer KRAS_12-61 AMER1 Any mutation 113 36 Signature 6 0.68 0.21 1.13 1162.65 1.00 184 96 19 17 FALSE 2.33
non-small cell lung cancer KRAS_12-61 AMER1 Any mutation 84 11 Signature 2 0.90 -0.21 2.07 1550.54 1.00 235 78 5 6 FALSE 0.90
non-small cell lung cancer KRAS_12-61 AMER1 Any mutation 269 83 Signature 4 0.05 -0.43 0.50 1435.72 1.00 398 238 52 31 FALSE 0.07
colorectal cancer KRAS_12-61 AMER1 Any mutation 612 131 Signature overall 0.67 0.24 1.14 1291.72 1.00 881 541 60 71 FALSE 2.45
non-small cell lung cancer KRAS_12-61 AMER1 Any mutation 353 94 Signature overall 0.46 -1.45 2.61 1264.36 1.00 633 316 57 37 FALSE 0.19
non-small cell lung cancer KRAS_12-61 EPHA7 Any mutation 48 13 Signature 3 -0.39 -1.60 0.81 1274.03 1.00 159 45 10 3 FALSE 0.28
non-small cell lung cancer KRAS_12-61 EPHA7 Any mutation 249 51 Signature 4 -0.84 -1.53 -0.19 1138.85 1.00 347 238 40 11 FALSE 1.90
non-small cell lung cancer KRAS_12-61 EPHA7 Any mutation 297 64 Signature overall -0.61 -2.10 0.98 1381.31 1.00 506 283 50 14 FALSE 0.37
uterine cancer KRAS_12-61 INPPL1 Any mutation 34 38 Signature 1A 0.65 -0.08 1.42 1273.91 1.00 98 21 25 13 FALSE 1.09
uterine cancer KRAS_12-61 INPPL1 Any mutation 6 13 Signature 20 0.23 -1.19 1.29 1556.42 1.00 12 4 11 2 FALSE 0.15
uterine cancer KRAS_12-61 INPPL1 Any mutation 14 40 Signature 6 0.46 -0.42 1.28 1523.68 1.00 40 6 32 8 FALSE 0.54
uterine cancer KRAS_12-61 INPPL1 Any mutation 54 91 Signature overall 0.44 -0.60 1.34 1489.37 1.00 150 31 68 23 FALSE 0.45
melanoma NRAS_12-61 SPEN Any mutation 135 105 Signature 7 -0.65 -1.21 -0.14 1397.75 1.00 258 115 85 20 FALSE 1.73
melanoma NRAS_12-61 SPEN Any mutation 135 105 Signature overall -0.54 -4.50 4.14 1470.75 1.00 258 115 85 20 FALSE 0.11
melanoma NRAS_12-61 KMT2C Any mutation 15 11 Signature 11 0.21 -1.01 1.73 919.70 1.01 34 10 6 5 FALSE 0.11
melanoma NRAS_12-61 KMT2C Any mutation 129 126 Signature 7 -0.70 -1.18 -0.19 1207.60 1.00 216 106 103 23 FALSE 2.22
melanoma NRAS_12-61 KMT2C Any mutation 144 137 Signature overall -0.23 -1.48 1.61 1297.77 1.00 250 116 109 28 FALSE 0.11
melanoma NRAS_12-61 TP53 Any mutation 15 14 Signature 11 -0.10 -0.87 0.87 1173.10 1.00 32 11 10 4 TRUE 0.09
melanoma NRAS_12-61 TP53 Any mutation 15 14 Signature 1A 0.15 -0.67 1.35 354.80 1.01 44 9 8 6 TRUE 0.11
melanoma NRAS_12-61 TP53 Any mutation 133 150 Signature 7 -0.35 -0.79 0.08 1354.35 1.00 215 100 117 33 TRUE 0.92
melanoma NRAS_12-61 TP53 Any mutation 163 178 Signature overall -0.10 -0.79 0.79 457.15 1.00 291 120 135 43 TRUE 0.10
melanoma NRAS_12-61 ATRX Any mutation 133 76 Signature 7 -0.57 -1.20 0.00 1383.42 1.00 275 118 61 15 TRUE 1.20
melanoma NRAS_12-61 ATRX Any mutation 133 76 Signature overall -0.48 -4.55 4.09 1386.41 1.00 275 118 61 15 TRUE 0.09
melanoma NRAS_12-61 PTPRD Any mutation 144 247 Signature 7 -0.60 -1.00 -0.25 155.26 1.02 197 93 196 51 FALSE 2.61
melanoma NRAS_12-61 PTPRD Any mutation 144 247 Signature overall -0.52 -4.26 3.71 1227.50 1.00 197 93 196 51 FALSE 0.11
melanoma NRAS_12-61 PIK3C2G Any mutation 134 174 Signature 7 -0.50 -0.94 -0.07 1387.62 1.00 207 96 136 38 FALSE 1.60
melanoma NRAS_12-61 PIK3C2G Any mutation 134 174 Signature overall -0.45 -4.68 3.49 1649.12 1.00 207 96 136 38 FALSE 0.09
melanoma NRAS_12-61 PTPRT Any mutation 16 12 Signature 11 -0.34 -1.63 0.89 1669.25 1.00 35 13 9 3 FALSE 0.22
melanoma NRAS_12-61 PTPRT Any mutation 150 346 Signature 7 -0.32 -0.69 0.06 1490.81 1.00 173 71 267 79 FALSE 1.02
melanoma NRAS_12-61 PTPRT Any mutation 166 358 Signature overall -0.30 -2.04 1.43 1362.88 1.00 208 84 276 82 FALSE 0.13
melanoma NRAS_12-61 ALK Any mutation 134 117 Signature 7 -0.62 -1.13 -0.04 166.67 1.02 244 111 94 23 TRUE 1.67
melanoma NRAS_12-61 ALK Any mutation 134 117 Signature overall -0.52 -5.15 4.01 1447.24 1.00 244 111 94 23 TRUE 0.10
melanoma NRAS_12-61 IKZF1 Any mutation 134 93 Signature 7 -0.48 -1.03 0.06 1531.02 1.00 260 114 73 20 TRUE 1.09
melanoma NRAS_12-61 IKZF1 Any mutation 134 93 Signature overall -0.48 -4.92 3.70 1531.45 1.00 260 114 73 20 TRUE 0.09
melanoma NRAS_12-61 FAT1 Any mutation 135 128 Signature 7 -0.36 -0.82 0.15 1100.95 1.00 244 105 98 30 FALSE 0.85
melanoma NRAS_12-61 FAT1 Any mutation 135 128 Signature overall -0.26 -4.34 3.91 1527.04 1.00 244 105 98 30 FALSE 0.05
melanoma NRAS_12-61 KMT2A Any mutation 134 124 Signature 7 -0.62 -1.11 -0.13 1105.24 1.00 250 110 100 24 FALSE 1.79
melanoma NRAS_12-61 KMT2A Any mutation 134 124 Signature overall -0.56 -4.67 3.40 1661.97 1.00 250 110 100 24 FALSE 0.11
melanoma NRAS_12-61 PAK7 Any mutation 134 205 Signature 7 -0.73 -1.15 -0.34 1473.87 1.00 177 93 164 41 FALSE 3.36
melanoma NRAS_12-61 PAK7 Any mutation 134 205 Signature overall -0.73 -4.82 3.61 1437.95 1.00 177 93 164 41 FALSE 0.15
melanoma NRAS_12-61 TERT Any mutation 17 48 Signature 11 1.11 -0.09 2.43 1560.90 1.00 11 2 33 15 TRUE 1.12
melanoma NRAS_12-61 TERT Any mutation 11 20 Signature 19 1.59 0.26 3.00 1206.69 1.00 6 1 10 10 TRUE 1.60
melanoma NRAS_12-61 TERT Any mutation 12 17 Signature 1A 1.41 0.35 2.55 1478.36 1.00 42 5 10 7 TRUE 1.92
melanoma NRAS_12-61 TERT Any mutation 152 473 Signature 7 0.88 0.27 1.51 1623.99 1.00 61 12 333 140 TRUE 2.27
melanoma NRAS_12-61 TERT Any mutation 192 558 Signature overall 1.22 0.06 2.47 1160.72 1.00 120 20 386 172 TRUE 1.39
melanoma NRAS_12-61 NOTCH3 Any mutation 132 116 Signature 7 -0.95 -1.51 -0.42 931.70 1.00 244 114 98 18 TRUE 3.14
melanoma NRAS_12-61 NOTCH3 Any mutation 132 116 Signature overall -0.87 -4.81 3.21 1524.66 1.00 244 114 98 18 TRUE 0.19
melanoma NRAS_12-61 NOTCH4 Any mutation 131 141 Signature 7 -0.39 -0.84 0.04 1522.73 1.00 215 98 108 33 TRUE 1.09
melanoma NRAS_12-61 NOTCH4 Any mutation 131 141 Signature overall -0.36 -4.34 3.78 1232.41 1.00 215 98 108 33 TRUE 0.07
melanoma NRAS_12-61 CDKN2A Any mutation 136 108 Signature 7 -0.25 -0.80 0.25 1096.73 1.00 242 108 80 28 TRUE 0.47
melanoma NRAS_12-61 CDKN2A Any mutation 136 108 Signature overall -0.26 -4.68 3.97 1463.41 1.00 242 108 80 28 TRUE 0.05
melanoma NRAS_12-61 KMT2D Any mutation 15 13 Signature 11 -0.17 -0.90 0.89 966.74 1.00 31 11 9 4 FALSE 0.16
melanoma NRAS_12-61 KMT2D Any mutation 146 184 Signature 7 -0.30 -0.66 0.10 871.00 1.01 236 102 140 44 FALSE 0.88
melanoma NRAS_12-61 KMT2D Any mutation 161 197 Signature overall -0.25 -1.22 0.94 1287.96 1.00 267 113 149 48 FALSE 0.20
colorectal cancer NRAS_12-61 APC Any mutation 12 469 Signature 15 0.23 -0.70 1.16 1363.58 1.00 79 4 461 8 TRUE 0.20
colorectal cancer NRAS_12-61 APC Any mutation 54 962 Signature 1A 1.03 0.33 1.76 1476.53 1.00 218 3 911 51 TRUE 2.28
colorectal cancer NRAS_12-61 APC Any mutation 6 42 Signature 3 1.18 0.22 2.21 1413.34 1.00 11 0 36 6 TRUE 1.72
colorectal cancer NRAS_12-61 APC Any mutation 15 355 Signature 6 0.70 -0.14 1.58 1461.74 1.00 93 2 342 13 TRUE 0.97
melanoma NRAS_12-61 APC Any mutation 132 102 Signature 7 -0.84 -1.43 -0.28 1414.25 1.00 252 115 85 17 TRUE 2.40
colorectal cancer NRAS_12-61 APC Any mutation 116 2462 Signature overall 0.77 0.08 1.48 1381.83 1.00 540 11 2357 105 TRUE 1.50
melanoma NRAS_12-61 APC Any mutation 132 102 Signature overall -0.68 -4.77 3.86 1306.71 1.00 252 115 85 17 TRUE 0.13
melanoma NRAS_12-61 ARID2 Any mutation 139 109 Signature 7 -0.07 -0.55 0.41 1536.06 1.00 262 108 78 31 FALSE 0.10
melanoma NRAS_12-61 ARID2 Any mutation 141 128 Signature overall -1.08 -4.53 1.44 1445.30 1.00 278 110 97 31 FALSE 0.32
melanoma NRAS_12-61 EPHA3 Any mutation 133 97 Signature 7 -0.04 -0.52 0.42 1040.07 1.00 265 106 70 27 FALSE 0.06
melanoma NRAS_12-61 EPHA3 Any mutation 133 97 Signature overall -0.05 -4.36 4.23 1402.08 1.00 265 106 70 27 FALSE 0.01
melanoma NRAS_12-61 KDR Any mutation 134 121 Signature 7 -0.49 -0.98 0.02 1143.88 1.00 245 108 95 26 TRUE 1.29
melanoma NRAS_12-61 KDR Any mutation 134 121 Signature overall -0.36 -4.73 4.07 1567.36 1.00 245 108 95 26 TRUE 0.07
melanoma NRAS_12-61 NTRK3 Any mutation 135 93 Signature 7 -0.50 -1.04 0.01 1399.26 1.00 258 115 73 20 FALSE 1.15
melanoma NRAS_12-61 NTRK3 Any mutation 135 93 Signature overall -0.32 -4.70 4.14 1436.35 1.00 258 115 73 20 FALSE 0.06
melanoma NRAS_12-61 GRIN2A Any mutation 15 13 Signature 11 -0.56 -1.75 0.71 1392.22 1.00 31 12 10 3 FALSE 0.45
melanoma NRAS_12-61 GRIN2A Any mutation 148 278 Signature 7 -0.63 -1.04 -0.23 1396.27 1.00 191 92 222 56 FALSE 2.74
melanoma NRAS_12-61 GRIN2A Any mutation 163 291 Signature overall -0.58 -2.08 0.95 1498.12 1.00 222 104 232 59 FALSE 0.34
melanoma NRAS_12-61 ERBB4 Any mutation 138 171 Signature 7 -0.93 -1.40 -0.48 798.35 1.00 217 109 142 29 TRUE 4.13
melanoma NRAS_12-61 ERBB4 Any mutation 138 171 Signature overall -0.84 -4.86 3.64 1246.81 1.00 217 109 142 29 TRUE 0.18
melanoma NRAS_12-61 NF1 Any mutation 15 17 Signature 11 -1.05 -2.10 0.16 1212.98 1.00 32 12 14 3 TRUE 1.20
melanoma NRAS_12-61 NF1 Any mutation 140 242 Signature 7 -1.27 -1.70 -0.87 1503.44 1.00 184 107 209 33 TRUE 8.43
melanoma NRAS_12-61 NF1 Any mutation 155 259 Signature overall -1.19 -2.39 0.21 1205.90 1.00 216 119 223 36 TRUE 1.20
melanoma NRAS_12-61 FLT1 Any mutation 134 110 Signature 7 -0.39 -0.89 0.11 1165.56 1.00 253 109 85 25 FALSE 0.92
melanoma NRAS_12-61 FLT1 Any mutation 134 110 Signature overall -0.30 -4.28 3.80 1404.61 1.00 253 109 85 25 FALSE 0.06
melanoma NRAS_12-61 ROS1 Any mutation 15 11 Signature 11 0.01 -1.29 1.37 1454.88 1.00 33 11 7 4 TRUE 0.00
melanoma NRAS_12-61 ROS1 Any mutation 143 231 Signature 7 -0.57 -0.96 -0.16 1541.66 1.00 206 96 184 47 TRUE 2.20
melanoma NRAS_12-61 ROS1 Any mutation 158 242 Signature overall -0.30 -1.81 1.45 1622.40 1.00 239 107 191 51 TRUE 0.16
melanoma NRAS_12-61 PIK3CG Any mutation 133 92 Signature 7 -0.86 -1.49 -0.24 1114.91 1.00 263 118 77 15 FALSE 2.24
melanoma NRAS_12-61 PIK3CG Any mutation 133 92 Signature overall -0.70 -4.78 3.96 1392.90 1.00 263 118 77 15 FALSE 0.13
melanoma NRAS_12-61 BRAF Any mutation 15 25 Signature 11 -1.84 -3.11 -0.62 1441.93 1.00 19 12 22 3 TRUE 2.53
melanoma NRAS_12-61 BRAF Any mutation 11 11 Signature 1A -2.42 -4.70 -0.73 1512.12 1.00 41 11 11 0 TRUE 1.97
melanoma NRAS_12-61 BRAF Any mutation 134 191 Signature 7 -2.19 -2.77 -1.67 1373.45 1.00 155 119 176 15 TRUE 14.01
melanoma NRAS_12-61 BRAF Any mutation 160 227 Signature overall -2.14 -3.50 -0.97 1598.98 1.00 215 142 209 18 TRUE 2.98
melanoma NRAS_12-61 CARD11 Any mutation 132 107 Signature 7 -0.85 -1.43 -0.34 1348.31 1.00 246 114 89 18 FALSE 2.59
melanoma NRAS_12-61 CARD11 Any mutation 132 107 Signature overall -0.70 -4.89 3.76 1497.85 1.00 246 114 89 18 FALSE 0.14
melanoma NRAS_12-61 TP63 Any mutation 128 152 Signature 7 -0.57 -1.04 -0.10 1672.67 1.00 205 96 120 32 FALSE 1.72
melanoma NRAS_12-61 TP63 Any mutation 128 152 Signature overall -0.49 -4.62 3.88 1374.14 1.00 205 96 120 32 FALSE 0.10
melanoma NRAS_12-61 ZFHX3 Any mutation 127 90 Signature 7 -0.78 -1.41 -0.24 1452.00 1.00 247 111 74 16 FALSE 2.00
melanoma NRAS_12-61 ZFHX3 Any mutation 128 129 Signature overall -1.69 -5.69 1.78 1601.70 1.00 263 112 113 16 FALSE 0.45
melanoma NRAS_12-61 PREX2 Any mutation 90 158 Signature 7 -0.48 -0.96 0.01 1474.10 1.00 113 54 122 36 FALSE 1.28
melanoma NRAS_12-61 PREX2 Any mutation 90 158 Signature overall -0.43 -4.37 3.90 1434.77 1.00 113 54 122 36 FALSE 0.09
melanoma NRAS_12-61 EPHA7 Any mutation 130 141 Signature 7 -0.45 -0.91 0.00 1464.13 1.00 226 99 110 31 FALSE 1.25
melanoma NRAS_12-61 EPHA7 Any mutation 130 141 Signature overall -0.46 -4.56 3.71 1540.76 1.00 226 99 110 31 FALSE 0.09
colorectal cancer RAS_12 SPEN Any mutation 8 21 Signature 10 -1.39 -3.02 -0.02 1537.55 1.00 18 7 20 1 FALSE 1.14
colorectal cancer RAS_12 SPEN Any mutation 101 18 Signature 15 -0.77 -2.00 0.23 1626.20 1.00 274 98 15 3 FALSE 0.75
colorectal cancer RAS_12 SPEN Any mutation 280 38 Signature 1A -0.22 -0.90 0.47 1557.28 1.00 545 268 26 12 FALSE 0.28
colorectal cancer RAS_12 SPEN Any mutation 73 61 Signature 6 -0.80 -1.63 -0.09 1522.21 1.00 201 65 53 8 FALSE 1.44
non-small cell lung cancer RAS_12 SPEN Any mutation 79 39 Signature 2 -3.93 -9.42 -1.30 1474.65 1.00 233 79 39 0 FALSE 1.15
non-small cell lung cancer RAS_12 SPEN Any mutation 231 24 Signature 4 0.06 -0.85 0.91 1316.19 1.00 459 222 15 9 FALSE 0.04
uterine cancer RAS_12 SPEN Any mutation 20 13 Signature 15 0.96 -0.19 2.12 1475.47 1.00 83 15 8 5 FALSE 0.99
uterine cancer RAS_12 SPEN Any mutation 36 21 Signature 1A -0.40 -1.79 0.71 1458.71 1.00 167 34 19 2 FALSE 0.28
uterine cancer RAS_12 SPEN Any mutation 14 21 Signature 6 0.79 -0.43 1.92 1470.88 1.00 73 9 16 5 FALSE 0.73
colorectal cancer RAS_12 SPEN Any mutation 462 138 Signature overall -0.76 -1.88 0.33 1593.28 1.00 1038 438 114 24 FALSE 0.74
non-small cell lung cancer RAS_12 SPEN Any mutation 310 63 Signature overall -1.67 -5.37 1.56 1392.93 1.00 692 301 54 9 FALSE 0.47
uterine cancer RAS_12 SPEN Any mutation 73 93 Signature overall 0.51 -0.85 2.02 1392.07 1.00 346 58 78 15 FALSE 0.34
colorectal cancer RAS_12 KMT2C Any mutation 9 32 Signature 10 -1.41 -2.96 -0.11 1508.12 1.00 15 7 30 2 FALSE 1.32
colorectal cancer RAS_12 KMT2C Any mutation 97 22 Signature 15 -0.89 -2.04 0.08 1335.31 1.00 268 94 19 3 FALSE 0.98
colorectal cancer RAS_12 KMT2C Any mutation 274 60 Signature 1A -0.29 -0.91 0.28 1590.01 1.00 519 257 43 17 FALSE 0.49
colorectal cancer RAS_12 KMT2C Any mutation 69 65 Signature 6 -0.32 -0.98 0.32 1458.27 1.00 193 57 53 12 FALSE 0.45
non-small cell lung cancer RAS_12 KMT2C Any mutation 13 22 Signature 13 0.08 -0.85 1.01 1657.56 1.00 69 9 18 4 FALSE 0.06
non-small cell lung cancer RAS_12 KMT2C Any mutation 80 40 Signature 2 0.16 -0.52 0.81 1398.77 1.00 218 68 28 12 FALSE 0.19
non-small cell lung cancer RAS_12 KMT2C Any mutation 49 13 Signature 3 -0.50 -1.67 0.44 1569.36 1.00 182 48 12 1 FALSE 0.47
non-small cell lung cancer RAS_12 KMT2C Any mutation 230 76 Signature 4 -0.28 -0.78 0.18 1415.61 1.00 422 210 56 20 FALSE 0.60
uterine cancer RAS_12 KMT2C Any mutation 18 17 Signature 15 -0.74 -2.34 0.56 1533.18 1.00 77 16 15 2 FALSE 0.50
uterine cancer RAS_12 KMT2C Any mutation 34 20 Signature 1A -0.84 -2.42 0.49 1446.38 1.00 154 32 18 2 FALSE 0.61
uterine cancer RAS_12 KMT2C Any mutation 13 23 Signature 6 -1.29 -3.07 0.17 1540.33 1.00 64 12 22 1 FALSE 0.85
colorectal cancer RAS_12 KMT2C Any mutation 449 179 Signature overall -0.71 -1.89 0.40 1543.86 1.00 995 415 145 34 FALSE 0.65
non-small cell lung cancer RAS_12 KMT2C Any mutation 372 151 Signature overall -0.14 -0.84 0.58 1578.27 1.00 891 335 114 37 FALSE 0.16
uterine cancer RAS_12 KMT2C Any mutation 67 118 Signature overall -0.82 -2.32 0.73 1580.80 1.00 315 60 111 7 FALSE 0.54
cancer of unknown primary RAS_12 TP53 Any mutation 12 11 Signature 11 0.02 -0.93 1.01 1374.54 1.00 8 5 4 7 TRUE 0.01
cancer of unknown primary RAS_12 TP53 Any mutation 10 28 Signature 15 -0.15 -1.04 0.79 1541.84 1.00 19 3 21 7 TRUE 0.13
cancer of unknown primary RAS_12 TP53 Any mutation 34 66 Signature 1A -0.51 -1.16 0.10 1589.68 1.00 36 19 51 15 TRUE 0.94
cancer of unknown primary RAS_12 TP53 Any mutation 9 31 Signature 2 -0.75 -1.63 0.11 1223.08 1.00 20 6 28 3 TRUE 1.05
cancer of unknown primary RAS_12 TP53 Any mutation 6 18 Signature 3 -0.53 -1.51 0.39 1691.84 1.00 6 3 15 3 TRUE 0.56
cancer of unknown primary RAS_12 TP53 Any mutation 21 70 Signature 4 -0.60 -1.36 0.12 1417.83 1.00 11 8 57 13 TRUE 0.94
colorectal cancer RAS_12 TP53 Any mutation 9 32 Signature 10 -0.96 -1.58 -0.36 1486.09 1.00 6 3 26 6 TRUE 2.67
colorectal cancer RAS_12 TP53 Any mutation 22 28 Signature 11 -0.57 -1.14 0.02 1528.39 1.00 2 7 13 15 TRUE 1.26
colorectal cancer RAS_12 TP53 Any mutation 103 311 Signature 15 -0.98 -1.36 -0.58 1485.77 1.00 58 39 247 64 TRUE 6.27
colorectal cancer RAS_12 TP53 Any mutation 8 36 Signature 17 -0.96 -1.60 -0.36 1440.91 1.00 8 2 30 6 TRUE 2.60
colorectal cancer RAS_12 TP53 Any mutation 17 36 Signature 18 -1.04 -1.68 -0.47 1505.98 1.00 3 9 28 8 TRUE 3.26
colorectal cancer RAS_12 TP53 Any mutation 20 31 Signature 19 -1.05 -1.68 -0.49 1528.78 1.00 5 12 23 8 TRUE 3.18
colorectal cancer RAS_12 TP53 Any mutation 294 655 Signature 1A -0.83 -1.11 -0.55 1490.45 1.00 123 110 471 184 TRUE 8.49
colorectal cancer RAS_12 TP53 Any mutation 7 15 Signature 1B -0.90 -1.62 -0.26 1392.15 1.00 4 3 11 4 TRUE 2.04
colorectal cancer RAS_12 TP53 Any mutation 38 56 Signature 2 -0.98 -1.53 -0.47 1502.63 1.00 9 20 38 18 TRUE 3.52
colorectal cancer RAS_12 TP53 Any mutation 9 23 Signature 20 -0.85 -1.48 -0.23 1538.23 1.00 8 3 17 6 TRUE 2.12
colorectal cancer RAS_12 TP53 Any mutation 7 20 Signature 21 -0.87 -1.51 -0.20 1458.21 1.00 6 2 15 5 TRUE 2.10
colorectal cancer RAS_12 TP53 Any mutation 14 35 Signature 3 -0.89 -1.49 -0.32 1415.96 1.00 2 5 26 9 TRUE 2.49
colorectal cancer RAS_12 TP53 Any mutation 18 36 Signature 4 -0.86 -1.49 -0.29 1501.07 1.00 3 7 25 11 TRUE 2.45
colorectal cancer RAS_12 TP53 Any mutation 84 236 Signature 6 -0.55 -0.98 -0.12 1449.44 1.00 84 28 180 56 TRUE 1.78
colorectal cancer RAS_12 TP53 Any mutation 15 28 Signature 7 -0.89 -1.56 -0.32 1436.21 1.00 5 7 20 8 TRUE 2.34
colorectal cancer RAS_12 TP53 Any mutation 14 13 Signature 8 -0.66 -1.28 -0.03 1358.16 1.00 4 6 5 8 TRUE 1.46
colorectal cancer RAS_12 TP53 Any mutation 17 16 Signature R2 -0.61 -1.22 -0.01 1487.54 1.00 0 7 6 10 TRUE 1.30
non-small cell lung cancer RAS_12 TP53 Any mutation 22 12 Signature 11 -1.44 -2.30 -0.63 1521.87 1.00 13 19 9 3 TRUE 3.17
non-small cell lung cancer RAS_12 TP53 Any mutation 15 79 Signature 13 -0.81 -1.54 -0.04 1446.59 1.00 27 4 68 11 TRUE 1.48
non-small cell lung cancer RAS_12 TP53 Any mutation 17 36 Signature 14 -1.15 -1.94 -0.39 1566.77 1.00 14 10 29 7 TRUE 2.43
non-small cell lung cancer RAS_12 TP53 Any mutation 20 87 Signature 15 -1.39 -2.11 -0.73 1336.37 1.00 40 13 80 7 TRUE 3.98
non-small cell lung cancer RAS_12 TP53 Any mutation 10 39 Signature 16 -0.83 -1.69 -0.03 1534.56 1.00 21 3 32 7 TRUE 1.33
non-small cell lung cancer RAS_12 TP53 Any mutation 58 92 Signature 18 -0.95 -1.50 -0.41 1407.72 1.00 32 32 66 26 TRUE 3.10
non-small cell lung cancer RAS_12 TP53 Any mutation 14 31 Signature 19 -1.10 -1.92 -0.31 1388.83 1.00 26 9 26 5 TRUE 2.10
non-small cell lung cancer RAS_12 TP53 Any mutation 46 149 Signature 1A -0.98 -1.54 -0.43 1398.09 1.00 96 28 131 18 TRUE 3.30
non-small cell lung cancer RAS_12 TP53 Any mutation 81 223 Signature 2 -0.81 -1.26 -0.38 1451.33 1.00 85 39 181 42 TRUE 3.46
non-small cell lung cancer RAS_12 TP53 Any mutation 13 46 Signature 20 -1.44 -2.30 -0.62 1585.03 1.00 22 9 42 4 TRUE 3.32
non-small cell lung cancer RAS_12 TP53 Any mutation 9 37 Signature 21 -1.73 -2.66 -0.84 1526.86 1.00 21 8 36 1 TRUE 3.85
non-small cell lung cancer RAS_12 TP53 Any mutation 52 161 Signature 3 -1.16 -1.70 -0.65 1518.17 1.00 65 30 139 22 TRUE 4.62
non-small cell lung cancer RAS_12 TP53 Any mutation 233 522 Signature 4 -1.70 -2.02 -1.39 1433.23 1.00 92 134 423 99 TRUE 25.06
non-small cell lung cancer RAS_12 TP53 Any mutation 11 36 Signature 6 -1.25 -2.05 -0.43 1404.80 1.00 11 6 31 5 TRUE 2.60
non-small cell lung cancer RAS_12 TP53 Any mutation 22 71 Signature 7 -1.36 -2.06 -0.68 1467.38 1.00 27 14 63 8 TRUE 3.94
non-small cell lung cancer RAS_12 TP53 Any mutation 26 35 Signature 8 -1.24 -2.01 -0.50 1640.98 1.00 11 17 26 9 TRUE 3.07
non-small cell lung cancer RAS_12 TP53 Any mutation 145 85 Signature R2 -1.39 -1.93 -0.89 1362.02 1.00 18 103 43 42 TRUE 6.60
non-small cell lung cancer RAS_12 TP53 Any mutation 6 15 Signature R3 -1.48 -2.48 -0.56 1380.62 1.00 12 5 14 1 TRUE 2.61
non-small cell lung cancer RAS_12 TP53 Any mutation 17 57 Signature U1 -1.76 -2.58 -0.96 1495.48 1.00 41 15 55 2 TRUE 4.61
non-small cell lung cancer RAS_12 TP53 Any mutation 9 32 Signature U2 -1.65 -2.61 -0.82 1532.56 1.00 8 7 30 2 TRUE 3.59
pancreatic cancer RAS_12 TP53 Any mutation 115 94 Signature 11 1.88 1.02 2.76 1341.54 1.00 5 26 5 89 TRUE 4.82
pancreatic cancer RAS_12 TP53 Any mutation 109 98 Signature 15 1.43 0.68 2.17 1452.66 1.00 10 25 14 84 TRUE 3.80
pancreatic cancer RAS_12 TP53 Any mutation 23 19 Signature 16 2.15 1.16 3.32 1523.66 1.00 7 5 1 18 TRUE 4.20
pancreatic cancer RAS_12 TP53 Any mutation 12 41 Signature 17 0.22 -0.75 1.16 1541.36 1.00 9 5 34 7 TRUE 0.18
pancreatic cancer RAS_12 TP53 Any mutation 14 14 Signature 18 2.08 1.06 3.21 1464.12 1.00 7 2 2 12 TRUE 3.89
pancreatic cancer RAS_12 TP53 Any mutation 14 16 Signature 19 1.90 0.86 2.99 1333.67 1.00 8 2 4 12 TRUE 3.54
pancreatic cancer RAS_12 TP53 Any mutation 201 172 Signature 1A 1.41 0.86 1.96 1305.77 1.00 28 53 24 148 TRUE 6.11
pancreatic cancer RAS_12 TP53 Any mutation 16 12 Signature 1B 1.88 0.75 3.00 1723.36 1.00 4 5 1 11 TRUE 3.14
pancreatic cancer RAS_12 TP53 Any mutation 33 29 Signature 2 2.31 1.36 3.33 1369.60 1.00 11 6 2 27 TRUE 5.47
pancreatic cancer RAS_12 TP53 Any mutation 25 21 Signature 21 2.22 1.21 3.41 1462.55 1.00 6 5 1 20 TRUE 4.41
pancreatic cancer RAS_12 TP53 Any mutation 79 66 Signature 3 2.10 1.34 2.94 1464.15 1.00 14 18 5 61 TRUE 6.64
pancreatic cancer RAS_12 TP53 Any mutation 61 58 Signature 4 2.41 1.55 3.29 1411.67 1.00 8 7 4 54 TRUE 7.18
pancreatic cancer RAS_12 TP53 Any mutation 54 53 Signature 6 1.68 0.89 2.50 1580.63 1.00 10 11 10 43 TRUE 4.61
pancreatic cancer RAS_12 TP53 Any mutation 23 25 Signature 7 2.42 1.45 3.52 1458.87 1.00 9 1 3 22 TRUE 5.05
pancreatic cancer RAS_12 TP53 Any mutation 49 37 Signature 8 2.26 1.29 3.27 1481.00 1.00 3 12 0 37 TRUE 5.03
pancreatic cancer RAS_12 TP53 Any mutation 21 19 Signature R3 2.29 1.28 3.42 1525.38 1.00 3 3 1 18 TRUE 4.39
pancreatic cancer RAS_12 TP53 Any mutation 11 11 Signature U1 2.22 1.20 3.36 1206.42 1.00 10 1 1 10 TRUE 4.08
uterine cancer RAS_12 TP53 Any mutation 19 53 Signature 15 -1.81 -2.83 -0.97 1470.19 1.00 39 16 50 3 TRUE 3.95
uterine cancer RAS_12 TP53 Any mutation 37 113 Signature 1A -1.19 -1.87 -0.50 1499.24 1.00 92 25 101 12 TRUE 3.13
uterine cancer RAS_12 TP53 Any mutation 6 19 Signature 2 -2.02 -3.39 -1.00 1299.24 1.00 23 6 19 0 TRUE 2.93
uterine cancer RAS_12 TP53 Any mutation 7 19 Signature 20 -1.80 -3.10 -0.76 1576.30 1.00 19 6 18 1 TRUE 2.67
uterine cancer RAS_12 TP53 Any mutation 11 30 Signature 3 -1.49 -2.51 -0.50 1570.80 1.00 10 7 26 4 TRUE 2.57
uterine cancer RAS_12 TP53 Any mutation 13 45 Signature 6 -2.20 -3.59 -1.18 1456.15 1.00 49 13 45 0 TRUE 3.55
cancer of unknown primary RAS_12 TP53 Any mutation 100 287 Signature overall -0.48 -1.05 0.14 1364.23 1.00 127 47 234 53 TRUE 0.93
colorectal cancer RAS_12 TP53 Any mutation 696 1607 Signature overall -0.85 -1.17 -0.54 1549.72 1.00 330 270 1181 426 TRUE 7.30
non-small cell lung cancer RAS_12 TP53 Any mutation 838 1927 Signature overall -1.30 -1.63 -1.01 1393.48 1.00 718 512 1601 326 TRUE 15.39
pancreatic cancer RAS_12 TP53 Any mutation 860 785 Signature overall 1.93 1.44 2.45 1367.55 1.00 152 187 112 673 TRUE 13.26
uterine cancer RAS_12 TP53 Any mutation 96 356 Signature overall -1.82 -2.59 -1.11 1432.15 1.00 282 76 336 20 TRUE 5.74
colorectal cancer RAS_12 ATRX Any mutation 8 19 Signature 10 -2.42 -5.27 -0.48 1592.20 1.00 18 8 19 0 TRUE 1.26
colorectal cancer RAS_12 ATRX Any mutation 279 46 Signature 1A -0.71 -1.49 -0.05 1524.43 1.00 536 269 36 10 TRUE 1.28
colorectal cancer RAS_12 ATRX Any mutation 72 29 Signature 6 -0.89 -2.03 0.07 1566.13 1.00 217 68 25 4 TRUE 1.00
non-small cell lung cancer RAS_12 ATRX Any mutation 58 12 Signature 18 0.14 -0.59 0.89 1425.18 1.00 87 52 6 6 TRUE 0.15
non-small cell lung cancer RAS_12 ATRX Any mutation 79 28 Signature 2 0.09 -0.55 0.76 1626.62 1.00 228 71 20 8 TRUE 0.10
non-small cell lung cancer RAS_12 ATRX Any mutation 234 88 Signature 4 -0.01 -0.43 0.44 1472.62 1.00 423 207 61 27 TRUE 0.02
uterine cancer RAS_12 ATRX Any mutation 36 12 Signature 1A -4.06 -8.58 -0.89 1526.60 1.00 171 36 12 0 TRUE 1.39
uterine cancer RAS_12 ATRX Any mutation 13 13 Signature 6 -3.97 -8.66 -0.71 1524.76 1.00 75 13 13 0 TRUE 1.28
colorectal cancer RAS_12 ATRX Any mutation 359 94 Signature overall -1.30 -3.18 0.34 1507.06 1.00 771 345 80 14 TRUE 0.84
non-small cell lung cancer RAS_12 ATRX Any mutation 371 128 Signature overall 0.08 -0.52 0.73 1363.56 1.00 738 330 87 41 TRUE 0.09
uterine cancer RAS_12 ATRX Any mutation 53 123 Signature overall -3.46 -7.03 -0.55 1557.08 1.00 272 52 122 1 TRUE 1.45
colorectal cancer RAS_12 ATR Any mutation 8 28 Signature 10 -1.89 -3.82 -0.50 1633.10 1.00 17 7 27 1 FALSE 1.62
colorectal cancer RAS_12 ATR Any mutation 101 12 Signature 15 -1.46 -3.27 0.03 1536.47 1.00 276 100 11 1 FALSE 1.12
colorectal cancer RAS_12 ATR Any mutation 280 32 Signature 1A -0.58 -1.44 0.19 1433.55 1.00 542 272 24 8 FALSE 0.78
colorectal cancer RAS_12 ATR Any mutation 74 28 Signature 6 -0.81 -1.92 0.14 1336.89 1.00 222 70 24 4 FALSE 0.89
non-small cell lung cancer RAS_12 ATR Any mutation 13 11 Signature 13 -0.19 -1.35 1.12 1452.13 1.00 76 11 9 2 FALSE 0.12
non-small cell lung cancer RAS_12 ATR Any mutation 79 16 Signature 2 -0.27 -1.19 0.67 1239.22 1.00 233 75 12 4 FALSE 0.25
non-small cell lung cancer RAS_12 ATR Any mutation 230 60 Signature 4 -0.60 -1.21 -0.01 1526.77 1.00 426 218 48 12 FALSE 1.30
colorectal cancer RAS_12 ATR Any mutation 463 100 Signature overall -1.16 -2.76 0.24 1567.44 1.00 1057 449 86 14 FALSE 0.93
non-small cell lung cancer RAS_12 ATR Any mutation 322 87 Signature overall -0.36 -1.32 0.64 1560.87 1.00 735 304 69 18 FALSE 0.33
non-small cell lung cancer RAS_12 PDGFRA Any mutation 79 20 Signature 2 -0.15 -0.96 0.68 1342.35 1.00 230 74 15 5 TRUE 0.14
non-small cell lung cancer RAS_12 PDGFRA Any mutation 232 70 Signature 4 -0.18 -0.76 0.32 1451.05 1.00 426 212 50 20 TRUE 0.29
non-small cell lung cancer RAS_12 PDGFRA Any mutation 311 90 Signature overall -0.17 -1.20 0.81 1228.93 1.00 656 286 65 25 TRUE 0.13
colorectal cancer RAS_12 FBXW7 Any mutation 8 17 Signature 10 -0.15 -1.30 0.78 1552.82 1.00 14 6 15 2 TRUE 0.12
colorectal cancer RAS_12 FBXW7 Any mutation 104 48 Signature 15 0.16 -0.42 0.71 1586.35 1.00 255 89 33 15 TRUE 0.23
colorectal cancer RAS_12 FBXW7 Any mutation 289 144 Signature 1A 0.13 -0.22 0.48 1334.61 1.00 485 237 92 52 TRUE 0.32
colorectal cancer RAS_12 FBXW7 Any mutation 76 78 Signature 6 0.37 -0.11 0.90 1521.57 1.00 189 52 54 24 TRUE 0.85
uterine cancer RAS_12 FBXW7 Any mutation 19 17 Signature 15 -0.43 -1.84 0.73 1580.79 1.00 75 17 15 2 TRUE 0.30
uterine cancer RAS_12 FBXW7 Any mutation 36 35 Signature 1A -0.06 -1.01 0.79 1359.42 1.00 155 30 29 6 TRUE 0.05
uterine cancer RAS_12 FBXW7 Any mutation 13 18 Signature 6 -0.26 -1.54 0.95 1549.06 1.00 68 11 16 2 TRUE 0.15
colorectal cancer RAS_12 FBXW7 Any mutation 477 287 Signature overall 0.13 -0.60 0.80 1484.55 1.00 943 384 194 93 TRUE 0.15
uterine cancer RAS_12 FBXW7 Any mutation 71 101 Signature overall -0.13 -1.34 1.07 1496.02 1.00 316 58 88 13 TRUE 0.08
uterine cancer RAS_12 NSD1 Any mutation 37 22 Signature 1A 0.06 -1.16 1.03 1567.77 1.00 168 33 18 4 FALSE 0.04
uterine cancer RAS_12 NSD1 Any mutation 16 29 Signature 6 0.80 -0.32 1.90 1423.31 1.00 69 9 22 7 FALSE 0.83
uterine cancer RAS_12 NSD1 Any mutation 55 88 Signature overall 0.47 -1.47 2.60 1314.97 1.00 254 42 75 13 FALSE 0.20
colorectal cancer RAS_12 FLT4 Any mutation 8 14 Signature 10 -0.89 -2.50 0.50 1455.20 1.00 20 7 13 1 TRUE 0.60
colorectal cancer RAS_12 FLT4 Any mutation 102 14 Signature 15 0.26 -0.77 1.30 1479.71 1.00 276 96 8 6 TRUE 0.21
colorectal cancer RAS_12 FLT4 Any mutation 282 54 Signature 1A -0.16 -0.74 0.39 1612.36 1.00 530 265 37 17 TRUE 0.25
colorectal cancer RAS_12 FLT4 Any mutation 72 51 Signature 6 -1.01 -1.92 -0.24 1495.92 1.00 199 67 46 5 TRUE 1.69
non-small cell lung cancer RAS_12 FLT4 Any mutation 79 11 Signature 2 -0.84 -2.26 0.20 1549.75 1.00 235 78 10 1 TRUE 0.72
non-small cell lung cancer RAS_12 FLT4 Any mutation 230 36 Signature 4 -0.51 -1.31 0.26 1466.30 1.00 447 221 27 9 TRUE 0.70
colorectal cancer RAS_12 FLT4 Any mutation 464 133 Signature overall -0.45 -1.63 0.64 1608.80 1.00 1025 435 104 29 TRUE 0.38
non-small cell lung cancer RAS_12 FLT4 Any mutation 309 47 Signature overall -0.67 -2.01 0.48 1462.10 1.00 682 299 37 10 TRUE 0.52
colorectal cancer RAS_12 PTPRD Any mutation 8 19 Signature 10 -1.25 -2.95 0.23 1203.69 1.00 19 7 18 1 FALSE 0.89
colorectal cancer RAS_12 PTPRD Any mutation 101 14 Signature 15 0.35 -0.70 1.38 1615.98 1.00 278 95 8 6 FALSE 0.28
colorectal cancer RAS_12 PTPRD Any mutation 279 31 Signature 1A -0.60 -1.41 0.16 1624.84 1.00 545 272 24 7 FALSE 0.84
colorectal cancer RAS_12 PTPRD Any mutation 72 31 Signature 6 -0.76 -1.87 0.16 1345.30 1.00 217 68 27 4 FALSE 0.88
non-small cell lung cancer RAS_12 PTPRD Any mutation 60 22 Signature 18 0.55 -0.20 1.36 1361.14 1.00 83 48 10 12 FALSE 0.78
non-small cell lung cancer RAS_12 PTPRD Any mutation 44 12 Signature 1A 0.18 -0.91 1.20 1499.31 1.00 213 41 9 3 FALSE 0.13
non-small cell lung cancer RAS_12 PTPRD Any mutation 79 33 Signature 2 0.12 -0.66 0.85 1583.13 1.00 222 70 24 9 FALSE 0.12
non-small cell lung cancer RAS_12 PTPRD Any mutation 13 12 Signature 20 -0.04 -1.31 1.15 1424.84 1.00 56 11 10 2 FALSE 0.03
non-small cell lung cancer RAS_12 PTPRD Any mutation 50 18 Signature 3 0.42 -0.50 1.28 1470.33 1.00 181 44 12 6 FALSE 0.45
non-small cell lung cancer RAS_12 PTPRD Any mutation 240 195 Signature 4 -0.24 -0.61 0.11 1594.82 1.00 366 186 141 54 FALSE 0.76
non-small cell lung cancer RAS_12 PTPRD Any mutation 145 18 Signature R2 -0.32 -1.16 0.48 1497.11 1.00 48 134 7 11 FALSE 0.34
non-small cell lung cancer RAS_12 PTPRD Any mutation 9 11 Signature U2 0.00 -1.18 1.18 1575.18 1.00 28 7 9 2 FALSE 0.00
colorectal cancer RAS_12 PTPRD Any mutation 460 95 Signature overall -0.54 -1.75 0.67 1498.90 1.00 1059 442 77 18 FALSE 0.41
non-small cell lung cancer RAS_12 PTPRD Any mutation 640 321 Signature overall 0.09 -0.56 0.72 1386.96 1.00 1197 541 222 99 FALSE 0.10
non-small cell lung cancer RAS_12 PIK3C2G Any mutation 79 17 Signature 2 -0.97 -2.09 0.08 1369.47 1.00 229 77 15 2 FALSE 1.13
non-small cell lung cancer RAS_12 PIK3C2G Any mutation 230 57 Signature 4 -0.79 -1.46 -0.20 1480.25 1.00 430 219 46 11 FALSE 1.85
non-small cell lung cancer RAS_12 PIK3C2G Any mutation 309 74 Signature overall -0.88 -2.04 0.18 1517.44 1.00 659 296 61 13 FALSE 0.87
colorectal cancer RAS_12 CREBBP Any mutation 8 15 Signature 10 -1.06 -2.74 0.31 1256.07 1.00 19 7 14 1 TRUE 0.77
colorectal cancer RAS_12 CREBBP Any mutation 101 27 Signature 15 -0.80 -1.85 0.06 1485.11 1.00 266 97 23 4 TRUE 0.98
colorectal cancer RAS_12 CREBBP Any mutation 283 45 Signature 1A 0.13 -0.49 0.74 1480.37 1.00 540 265 27 18 TRUE 0.17
colorectal cancer RAS_12 CREBBP Any mutation 79 80 Signature 6 -0.80 -1.47 -0.13 1416.29 1.00 187 68 69 11 TRUE 1.66
non-small cell lung cancer RAS_12 CREBBP Any mutation 44 12 Signature 1A 0.09 -0.69 0.90 1293.61 1.00 213 41 9 3 TRUE 0.08
non-small cell lung cancer RAS_12 CREBBP Any mutation 79 15 Signature 2 -0.16 -1.06 0.56 1327.37 1.00 232 77 13 2 TRUE 0.16
non-small cell lung cancer RAS_12 CREBBP Any mutation 50 11 Signature 3 0.06 -0.75 0.81 1402.32 1.00 185 47 8 3 TRUE 0.05
non-small cell lung cancer RAS_12 CREBBP Any mutation 230 44 Signature 4 0.09 -0.52 0.60 1507.34 1.00 448 215 29 15 TRUE 0.12
colorectal cancer RAS_12 CREBBP Any mutation 471 167 Signature overall -0.64 -1.73 0.31 1414.65 1.00 1012 437 133 34 TRUE 0.65
non-small cell lung cancer RAS_12 CREBBP Any mutation 403 82 Signature overall 0.01 -0.67 0.66 1320.59 1.00 1078 380 59 23 TRUE 0.02
colorectal cancer RAS_12 AXIN2 Any mutation 101 17 Signature 15 -0.24 -1.31 0.83 1617.73 1.00 274 96 12 5 TRUE 0.18
colorectal cancer RAS_12 AXIN2 Any mutation 279 36 Signature 1A -0.42 -1.18 0.29 1504.88 1.00 544 269 26 10 TRUE 0.58
colorectal cancer RAS_12 AXIN2 Any mutation 72 40 Signature 6 -2.44 -5.34 -0.84 1583.44 1.00 209 72 40 0 TRUE 1.34
colorectal cancer RAS_12 AXIN2 Any mutation 452 93 Signature overall -1.02 -2.76 0.43 1494.82 1.00 1027 437 78 15 TRUE 0.72
non-small cell lung cancer RAS_12 DOT1L Any mutation 79 16 Signature 2 -0.28 -1.25 0.54 1518.20 1.00 232 76 13 3 FALSE 0.27
non-small cell lung cancer RAS_12 DOT1L Any mutation 230 38 Signature 4 -0.12 -0.84 0.51 1576.40 1.00 447 218 26 12 FALSE 0.15
non-small cell lung cancer RAS_12 DOT1L Any mutation 309 54 Signature overall -0.21 -1.25 0.71 1357.06 1.00 679 294 39 15 FALSE 0.16
colorectal cancer RAS_12 PTPRS Any mutation 8 16 Signature 10 -1.46 -3.42 -0.06 1431.81 1.00 16 8 16 0 FALSE 1.07
colorectal cancer RAS_12 PTPRS Any mutation 98 38 Signature 15 0.06 -0.68 0.78 1639.96 1.00 258 86 26 12 FALSE 0.06
colorectal cancer RAS_12 PTPRS Any mutation 273 95 Signature 1A -0.14 -0.59 0.31 1576.47 1.00 496 243 65 30 FALSE 0.26
colorectal cancer RAS_12 PTPRS Any mutation 72 83 Signature 6 -0.98 -1.68 -0.27 1492.90 1.00 182 63 74 9 FALSE 2.20
colorectal cancer RAS_12 PTPRS Any mutation 451 232 Signature overall -0.63 -1.71 0.26 1428.91 1.00 952 400 181 51 FALSE 0.67
colorectal cancer RAS_12 SMARCA4 Any mutation 102 22 Signature 15 -0.12 -0.89 0.75 1473.08 1.00 274 95 15 7 FALSE 0.12
colorectal cancer RAS_12 SMARCA4 Any mutation 282 74 Signature 1A -0.35 -0.83 0.14 1594.74 1.00 523 262 54 20 FALSE 0.77
colorectal cancer RAS_12 SMARCA4 Any mutation 73 52 Signature 6 -0.80 -1.65 -0.12 1627.70 1.00 206 68 47 5 FALSE 1.39
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 13 11 Signature 13 0.17 -0.93 1.29 1555.38 1.00 76 11 9 2 FALSE 0.12
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 57 14 Signature 18 0.18 -0.66 1.01 1545.73 1.00 86 51 8 6 FALSE 0.16
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 44 17 Signature 1A 0.04 -0.97 0.92 1508.54 1.00 210 41 14 3 FALSE 0.03
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 81 33 Signature 2 0.00 -0.78 0.74 1504.36 1.00 225 73 25 8 FALSE 0.00
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 50 16 Signature 3 0.69 -0.23 1.56 1346.42 1.00 185 43 9 7 FALSE 0.88
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 231 104 Signature 4 -0.21 -0.66 0.20 1638.71 1.00 403 202 75 29 FALSE 0.44
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 21 15 Signature 7 0.28 -0.69 1.22 1582.78 1.00 76 17 11 4 FALSE 0.24
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 144 15 Signature R2 -0.09 -0.92 0.72 1494.44 1.00 49 134 5 10 FALSE 0.08
uterine cancer RAS_12 SMARCA4 Any mutation 19 14 Signature 15 -0.39 -1.71 0.76 1425.91 1.00 82 17 12 2 FALSE 0.28
uterine cancer RAS_12 SMARCA4 Any mutation 36 21 Signature 1A -0.57 -1.75 0.48 1533.07 1.00 166 34 19 2 FALSE 0.50
uterine cancer RAS_12 SMARCA4 Any mutation 15 30 Signature 6 -0.44 -1.55 0.54 1501.61 1.00 69 12 27 3 FALSE 0.39
colorectal cancer RAS_12 SMARCA4 Any mutation 457 148 Signature overall -0.43 -1.23 0.40 1481.94 1.00 1003 425 116 32 FALSE 0.52
non-small cell lung cancer RAS_12 SMARCA4 Any mutation 641 225 Signature overall 0.13 -0.43 0.72 1450.69 1.00 1310 572 156 69 FALSE 0.18
uterine cancer RAS_12 SMARCA4 Any mutation 71 76 Signature overall -0.42 -1.53 0.68 1449.59 1.00 346 63 68 8 FALSE 0.35
colorectal cancer RAS_12 PTPRT Any mutation 8 23 Signature 10 -2.41 -5.08 -0.71 1428.75 1.00 16 8 23 0 FALSE 1.49
colorectal cancer RAS_12 PTPRT Any mutation 101 25 Signature 15 -1.95 -3.82 -0.60 1480.68 1.00 261 100 24 1 FALSE 1.88
colorectal cancer RAS_12 PTPRT Any mutation 280 66 Signature 1A -0.31 -0.86 0.20 1608.23 1.00 520 261 47 19 FALSE 0.61
colorectal cancer RAS_12 PTPRT Any mutation 74 43 Signature 6 -0.54 -1.34 0.21 1527.38 1.00 205 66 35 8 FALSE 0.75
non-small cell lung cancer RAS_12 PTPRT Any mutation 13 11 Signature 13 0.32 -0.94 1.62 1663.20 1.00 79 10 8 3 FALSE 0.21
non-small cell lung cancer RAS_12 PTPRT Any mutation 57 17 Signature 18 -0.38 -1.36 0.58 1305.91 1.00 82 52 12 5 FALSE 0.36
non-small cell lung cancer RAS_12 PTPRT Any mutation 44 11 Signature 1A -1.03 -2.69 0.33 1356.10 1.00 214 44 11 0 FALSE 0.74
non-small cell lung cancer RAS_12 PTPRT Any mutation 80 30 Signature 2 0.69 -0.10 1.39 1507.94 1.00 229 67 17 13 FALSE 1.14
non-small cell lung cancer RAS_12 PTPRT Any mutation 50 19 Signature 3 -0.72 -1.92 0.38 1620.60 1.00 178 48 17 2 FALSE 0.67
non-small cell lung cancer RAS_12 PTPRT Any mutation 234 179 Signature 4 -0.81 -1.22 -0.42 1213.78 1.00 366 200 145 34 FALSE 4.01
non-small cell lung cancer RAS_12 PTPRT Any mutation 146 23 Signature R2 -0.24 -1.11 0.57 1255.54 1.00 49 131 8 15 FALSE 0.24
colorectal cancer RAS_12 PTPRT Any mutation 463 157 Signature overall -1.25 -2.81 0.02 1430.80 1.00 1002 435 129 28 FALSE 1.14
non-small cell lung cancer RAS_12 PTPRT Any mutation 624 290 Signature overall -0.30 -1.13 0.50 1558.55 1.00 1197 552 218 72 FALSE 0.33
non-small cell lung cancer RAS_12 HGF Any mutation 79 20 Signature 2 0.26 -0.70 1.16 1682.92 1.00 232 72 13 7 FALSE 0.23
non-small cell lung cancer RAS_12 HGF Any mutation 230 89 Signature 4 -0.44 -0.95 0.05 1427.95 1.00 414 208 67 22 FALSE 1.10
non-small cell lung cancer RAS_12 HGF Any mutation 145 12 Signature R2 -1.09 -2.12 -0.06 1487.82 1.00 48 140 7 5 FALSE 1.40
non-small cell lung cancer RAS_12 HGF Any mutation 454 121 Signature overall -0.43 -1.79 0.91 1549.60 1.00 694 420 87 34 FALSE 0.28
colorectal cancer RAS_12 PIK3CA Any mutation 9 23 Signature 10 0.00 -0.91 0.78 1375.39 1.00 15 5 19 4 TRUE 0.00
colorectal cancer RAS_12 PIK3CA Any mutation 101 63 Signature 15 -0.02 -0.58 0.52 1512.55 1.00 242 85 47 16 TRUE 0.03
colorectal cancer RAS_12 PIK3CA Any mutation 17 19 Signature 18 0.08 -0.77 0.90 1555.53 1.00 18 11 13 6 TRUE 0.07
colorectal cancer RAS_12 PIK3CA Any mutation 286 191 Signature 1A 0.37 0.06 0.70 1521.66 1.00 464 209 114 77 TRUE 1.68
colorectal cancer RAS_12 PIK3CA Any mutation 39 43 Signature 2 0.82 0.20 1.53 1531.07 1.00 28 14 18 25 TRUE 1.80
colorectal cancer RAS_12 PIK3CA Any mutation 75 95 Signature 6 -0.03 -0.54 0.48 1577.88 1.00 177 54 74 21 TRUE 0.04
non-small cell lung cancer RAS_12 PIK3CA Any mutation 14 13 Signature 13 1.09 0.03 2.30 1467.93 1.00 78 8 7 6 TRUE 1.25
non-small cell lung cancer RAS_12 PIK3CA Any mutation 44 13 Signature 1A 0.19 -0.81 1.15 1527.44 1.00 213 41 10 3 TRUE 0.14
non-small cell lung cancer RAS_12 PIK3CA Any mutation 80 82 Signature 2 0.14 -0.43 0.65 1532.87 1.00 189 59 61 21 TRUE 0.20
non-small cell lung cancer RAS_12 PIK3CA Any mutation 13 16 Signature 20 0.13 -1.00 1.20 1430.61 1.00 51 10 13 3 TRUE 0.09
non-small cell lung cancer RAS_12 PIK3CA Any mutation 50 15 Signature 3 -0.87 -2.41 0.31 1436.80 1.00 178 50 15 0 TRUE 0.69
non-small cell lung cancer RAS_12 PIK3CA Any mutation 230 38 Signature 4 -0.17 -0.86 0.47 1419.81 1.00 446 219 27 11 TRUE 0.21
uterine cancer RAS_12 PIK3CA Any mutation 22 50 Signature 15 0.32 -0.47 1.10 1639.65 1.00 56 12 40 10 TRUE 0.38
uterine cancer RAS_12 PIK3CA Any mutation 42 138 Signature 1A 0.94 0.29 1.61 1357.19 1.00 103 11 107 31 TRUE 2.29
uterine cancer RAS_12 PIK3CA Any mutation 7 30 Signature 2 0.62 -0.45 1.70 1434.41 1.00 18 2 25 5 TRUE 0.59
uterine cancer RAS_12 PIK3CA Any mutation 8 25 Signature 20 0.32 -0.80 1.32 1263.23 1.01 15 4 21 4 TRUE 0.25
uterine cancer RAS_12 PIK3CA Any mutation 12 21 Signature 3 1.21 0.24 2.21 1280.24 1.00 23 3 12 9 TRUE 1.75
uterine cancer RAS_12 PIK3CA Any mutation 20 85 Signature 6 0.90 -0.01 1.77 1496.72 1.00 36 3 68 17 TRUE 1.33
colorectal cancer RAS_12 PIK3CA Any mutation 527 434 Signature overall 0.20 -0.32 0.71 1547.74 1.00 944 378 285 149 TRUE 0.34
non-small cell lung cancer RAS_12 PIK3CA Any mutation 431 177 Signature overall 0.09 -0.71 0.85 1520.63 1.00 1155 387 133 44 TRUE 0.08
uterine cancer RAS_12 PIK3CA Any mutation 117 459 Signature overall 0.50 -0.21 1.25 1422.57 1.00 319 37 379 80 TRUE 0.75
colorectal cancer RAS_12 ALK Any mutation 8 13 Signature 10 -2.00 -4.66 -0.15 1440.86 1.00 18 8 13 0 TRUE 1.10
colorectal cancer RAS_12 ALK Any mutation 101 16 Signature 15 0.05 -1.02 1.06 1360.54 1.00 274 95 10 6 TRUE 0.04
colorectal cancer RAS_12 ALK Any mutation 279 35 Signature 1A -0.69 -1.51 0.05 1540.19 1.00 542 271 27 8 TRUE 1.07
colorectal cancer RAS_12 ALK Any mutation 72 37 Signature 6 -2.03 -3.80 -0.76 1247.75 1.00 210 71 36 1 TRUE 2.02
non-small cell lung cancer RAS_12 ALK Any mutation 79 24 Signature 2 0.23 -0.42 0.94 1552.07 1.00 231 71 16 8 TRUE 0.28
non-small cell lung cancer RAS_12 ALK Any mutation 230 72 Signature 4 0.04 -0.47 0.53 1368.49 1.00 428 207 49 23 TRUE 0.05
colorectal cancer RAS_12 ALK Any mutation 460 101 Signature overall -1.15 -2.64 0.18 1459.59 1.00 1044 445 86 15 TRUE 1.03
non-small cell lung cancer RAS_12 ALK Any mutation 309 96 Signature overall 0.14 -0.80 1.16 1458.45 1.00 659 278 65 31 TRUE 0.11
colorectal cancer RAS_12 RNF43 Any mutation 104 31 Signature 15 -0.35 -1.12 0.48 1347.68 1.00 268 96 23 8 TRUE 0.40
colorectal cancer RAS_12 RNF43 Any mutation 284 93 Signature 1A -0.80 -1.33 -0.31 1607.36 1.00 515 266 75 18 TRUE 2.68
colorectal cancer RAS_12 RNF43 Any mutation 74 102 Signature 6 -1.22 -1.95 -0.60 1548.72 1.00 173 65 93 9 TRUE 3.38
colorectal cancer RAS_12 RNF43 Any mutation 462 226 Signature overall -0.78 -1.82 0.35 1339.30 1.00 956 427 191 35 TRUE 0.86
colorectal cancer RAS_12 PTEN Any mutation 8 13 Signature 10 -0.81 -2.24 0.34 1634.02 1.00 18 7 12 1 TRUE 0.67
colorectal cancer RAS_12 PTEN Any mutation 101 22 Signature 15 0.07 -0.80 0.90 1463.95 1.00 271 93 14 8 TRUE 0.06
colorectal cancer RAS_12 PTEN Any mutation 280 64 Signature 1A -0.86 -1.50 -0.26 1508.45 1.00 528 269 53 11 TRUE 2.20
colorectal cancer RAS_12 PTEN Any mutation 75 57 Signature 6 -0.54 -1.25 0.14 1300.88 1.00 208 66 48 9 TRUE 0.86
non-small cell lung cancer RAS_12 PTEN Any mutation 79 27 Signature 2 -0.74 -1.73 0.20 1505.23 1.00 225 75 23 4 TRUE 0.88
non-small cell lung cancer RAS_12 PTEN Any mutation 230 27 Signature 4 -0.85 -1.76 -0.03 1645.06 1.00 451 225 22 5 TRUE 1.20
uterine cancer RAS_12 PTEN Any mutation 27 61 Signature 15 1.00 0.28 1.69 1461.40 1.00 61 8 42 19 TRUE 2.20
uterine cancer RAS_12 PTEN Any mutation 49 155 Signature 1A 0.74 0.19 1.32 1540.41 1.00 113 15 121 34 TRUE 1.96
uterine cancer RAS_12 PTEN Any mutation 8 26 Signature 2 0.60 -0.36 1.56 1367.68 1.00 25 3 21 5 TRUE 0.64
uterine cancer RAS_12 PTEN Any mutation 10 28 Signature 20 0.91 -0.03 1.90 1418.49 1.00 19 2 20 8 TRUE 1.22
uterine cancer RAS_12 PTEN Any mutation 14 17 Signature 3 1.13 0.33 2.06 1392.00 1.00 29 5 8 9 TRUE 1.83
uterine cancer RAS_12 PTEN Any mutation 19 104 Signature 6 0.15 -0.63 1.01 1508.92 1.00 24 6 91 13 TRUE 0.14
colorectal cancer RAS_12 PTEN Any mutation 464 156 Signature overall -0.53 -1.52 0.41 1400.24 1.00 1025 435 127 29 TRUE 0.58
non-small cell lung cancer RAS_12 PTEN Any mutation 309 54 Signature overall -0.79 -2.04 0.44 1244.68 1.00 676 300 45 9 TRUE 0.64
uterine cancer RAS_12 PTEN Any mutation 146 545 Signature overall 0.52 -0.03 1.09 1546.03 1.00 344 45 444 101 TRUE 1.16
colorectal cancer RAS_12 BCOR Any mutation 8 11 Signature 10 -0.79 -2.48 0.70 1472.41 1.00 19 7 10 1 FALSE 0.49
colorectal cancer RAS_12 BCOR Any mutation 101 13 Signature 15 -0.10 -1.23 0.94 1444.95 1.00 276 97 9 4 FALSE 0.07
colorectal cancer RAS_12 BCOR Any mutation 279 27 Signature 1A 0.28 -0.44 1.04 1578.01 1.00 551 267 15 12 FALSE 0.34
colorectal cancer RAS_12 BCOR Any mutation 75 49 Signature 6 -1.19 -2.21 -0.36 1552.70 1.00 205 71 45 4 FALSE 1.86
non-small cell lung cancer RAS_12 BCOR Any mutation 80 13 Signature 2 0.37 -0.49 1.18 1205.49 1.00 236 76 9 4 FALSE 0.41
non-small cell lung cancer RAS_12 BCOR Any mutation 233 52 Signature 4 0.53 -0.02 1.02 942.20 1.01 447 210 29 23 FALSE 1.37
uterine cancer RAS_12 BCOR Any mutation 36 30 Signature 1A 0.04 -1.03 0.95 1568.34 1.00 160 31 25 5 FALSE 0.03
uterine cancer RAS_12 BCOR Any mutation 15 23 Signature 6 1.18 0.06 2.33 1335.66 1.00 72 8 16 7 FALSE 1.39
colorectal cancer RAS_12 BCOR Any mutation 463 100 Signature overall -0.44 -1.70 0.72 1553.02 1.00 1051 442 79 21 FALSE 0.32
non-small cell lung cancer RAS_12 BCOR Any mutation 313 65 Signature overall 0.47 -0.59 1.48 1598.16 1.00 683 286 38 27 FALSE 0.43
uterine cancer RAS_12 BCOR Any mutation 52 83 Signature overall 0.50 -1.26 2.61 1599.63 1.00 254 39 70 13 FALSE 0.23
colorectal cancer RAS_12 CTNNB1 Any mutation 101 22 Signature 15 0.12 -0.60 0.78 1369.08 1.01 269 95 16 6 TRUE 0.13
colorectal cancer RAS_12 CTNNB1 Any mutation 282 61 Signature 1A 0.45 -0.02 0.95 1486.70 1.00 534 253 32 29 TRUE 1.18
colorectal cancer RAS_12 CTNNB1 Any mutation 73 33 Signature 6 0.03 -0.76 0.65 1440.34 1.00 214 67 27 6 TRUE 0.03
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 44 11 Signature 1A -1.29 -2.66 -0.03 1632.38 1.00 212 43 10 1 TRUE 1.24
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 79 14 Signature 2 -1.45 -2.82 -0.31 1690.49 1.00 232 78 13 1 TRUE 1.58
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 50 17 Signature 3 -1.02 -2.32 0.16 1538.87 1.00 179 47 14 3 TRUE 0.96
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 230 16 Signature 4 -1.78 -3.52 -0.65 1528.61 1.00 456 230 16 0 TRUE 1.91
uterine cancer RAS_12 CTNNB1 Any mutation 19 11 Signature 15 -2.01 -4.00 -0.51 1588.73 1.00 80 19 11 0 TRUE 1.65
uterine cancer RAS_12 CTNNB1 Any mutation 36 31 Signature 1A -1.67 -3.26 -0.38 1363.31 1.00 155 34 29 2 TRUE 1.66
uterine cancer RAS_12 CTNNB1 Any mutation 13 19 Signature 6 -1.70 -3.42 -0.30 1376.84 1.00 68 12 18 1 TRUE 1.47
colorectal cancer RAS_12 CTNNB1 Any mutation 456 116 Signature overall 0.20 -0.54 0.87 1499.94 1.00 1017 415 75 41 TRUE 0.26
non-small cell lung cancer RAS_12 CTNNB1 Any mutation 403 58 Signature overall -1.38 -2.62 -0.38 1705.31 1.00 1079 398 53 5 TRUE 1.79
uterine cancer RAS_12 CTNNB1 Any mutation 70 83 Signature overall -1.81 -3.42 -0.50 1434.46 1.00 370 67 80 3 TRUE 1.87
cancer of unknown primary RAS_12 ARID1A Any mutation 34 22 Signature 1A -0.37 -1.24 0.57 1480.86 1.00 72 28 16 6 TRUE 0.37
cancer of unknown primary RAS_12 ARID1A Any mutation 8 13 Signature 2 -0.45 -1.42 0.65 1414.10 1.00 37 6 11 2 TRUE 0.41
cancer of unknown primary RAS_12 ARID1A Any mutation 19 12 Signature 4 -0.54 -1.61 0.39 1542.62 1.00 52 17 10 2 TRUE 0.54
colorectal cancer RAS_12 ARID1A Any mutation 8 13 Signature 10 -0.88 -2.02 0.11 1409.65 1.00 19 7 12 1 TRUE 0.96
colorectal cancer RAS_12 ARID1A Any mutation 102 39 Signature 15 -0.90 -1.70 -0.22 1454.56 1.00 265 97 34 5 TRUE 1.82
colorectal cancer RAS_12 ARID1A Any mutation 286 130 Signature 1A -0.59 -1.01 -0.18 1409.08 1.00 497 256 100 30 TRUE 2.25
colorectal cancer RAS_12 ARID1A Any mutation 78 99 Signature 6 -0.61 -1.17 -0.05 1339.03 1.00 181 62 83 16 TRUE 1.53
non-small cell lung cancer RAS_12 ARID1A Any mutation 13 17 Signature 13 -1.12 -2.78 0.23 1407.60 1.00 70 13 17 0 TRUE 0.85
non-small cell lung cancer RAS_12 ARID1A Any mutation 60 12 Signature 18 0.64 -0.43 1.67 1680.70 1.00 89 52 4 8 TRUE 0.64
non-small cell lung cancer RAS_12 ARID1A Any mutation 83 52 Signature 2 0.45 -0.19 1.08 1621.79 1.00 216 65 34 18 TRUE 0.78
non-small cell lung cancer RAS_12 ARID1A Any mutation 50 11 Signature 3 -0.34 -1.66 0.87 1459.15 1.00 184 48 9 2 TRUE 0.22
non-small cell lung cancer RAS_12 ARID1A Any mutation 231 86 Signature 4 -0.88 -1.44 -0.35 1364.38 1.00 403 216 71 15 TRUE 2.63
non-small cell lung cancer RAS_12 ARID1A Any mutation 144 13 Signature R2 -0.21 -1.13 0.73 1597.98 1.00 50 135 4 9 TRUE 0.18
pancreatic cancer RAS_12 ARID1A Any mutation 116 12 Signature 11 -0.13 -1.40 1.49 1427.88 1.00 9 105 1 11 TRUE 0.07
pancreatic cancer RAS_12 ARID1A Any mutation 203 33 Signature 1A -0.20 -1.02 0.66 1424.76 1.00 45 178 8 25 TRUE 0.19
uterine cancer RAS_12 ARID1A Any mutation 24 58 Signature 15 1.11 0.30 1.96 1300.77 1.00 62 8 42 16 TRUE 2.06
uterine cancer RAS_12 ARID1A Any mutation 46 133 Signature 1A 1.00 0.38 1.62 1429.24 1.00 116 14 101 32 TRUE 2.73
uterine cancer RAS_12 ARID1A Any mutation 9 23 Signature 2 1.51 0.42 2.72 1461.15 1.00 28 1 15 8 TRUE 2.04
uterine cancer RAS_12 ARID1A Any mutation 8 26 Signature 20 1.30 0.17 2.45 1544.54 1.00 20 1 19 7 TRUE 1.65
uterine cancer RAS_12 ARID1A Any mutation 18 121 Signature 6 0.86 -0.14 1.88 1455.42 1.00 28 2 105 16 TRUE 1.05
cancer of unknown primary RAS_12 ARID1A Any mutation 66 58 Signature overall -0.50 -1.46 0.37 1379.71 1.00 177 56 48 10 TRUE 0.56
colorectal cancer RAS_12 ARID1A Any mutation 474 281 Signature overall -0.75 -1.44 -0.08 1380.71 1.00 962 422 229 52 TRUE 1.58
non-small cell lung cancer RAS_12 ARID1A Any mutation 581 191 Signature overall -0.24 -1.15 0.63 1565.56 1.00 1012 529 139 52 TRUE 0.23
pancreatic cancer RAS_12 ARID1A Any mutation 319 45 Signature overall -0.15 -1.77 1.66 1411.47 1.00 54 283 9 36 TRUE 0.06
uterine cancer RAS_12 ARID1A Any mutation 110 445 Signature overall 0.90 0.18 1.68 1519.44 1.00 282 28 363 82 TRUE 1.72
colorectal cancer RAS_12 PIK3R1 Any mutation 10 17 Signature 10 -0.41 -1.75 0.82 1500.28 1.00 17 7 14 3 TRUE 0.28
colorectal cancer RAS_12 PIK3R1 Any mutation 101 17 Signature 15 0.37 -0.56 1.28 1263.40 1.00 277 94 10 7 TRUE 0.36
colorectal cancer RAS_12 PIK3R1 Any mutation 280 31 Signature 1A -0.14 -0.89 0.60 1587.26 1.00 547 270 21 10 TRUE 0.15
colorectal cancer RAS_12 PIK3R1 Any mutation 72 31 Signature 6 -0.89 -2.00 0.08 1487.22 1.00 215 69 28 3 TRUE 1.01
uterine cancer RAS_12 PIK3R1 Any mutation 21 32 Signature 15 -0.11 -0.91 0.88 764.05 1.01 71 12 23 9 TRUE 0.08
uterine cancer RAS_12 PIK3R1 Any mutation 37 59 Signature 1A -0.81 -1.69 -0.09 1006.44 1.00 135 33 55 4 TRUE 1.34
uterine cancer RAS_12 PIK3R1 Any mutation 7 13 Signature 20 -0.52 -1.46 0.42 1409.61 1.00 25 5 11 2 TRUE 0.59
uterine cancer RAS_12 PIK3R1 Any mutation 13 31 Signature 6 -0.96 -2.31 -0.13 1018.86 1.00 61 13 31 0 TRUE 1.06
colorectal cancer RAS_12 PIK3R1 Any mutation 463 96 Signature overall -0.25 -1.32 0.82 1422.33 1.00 1056 440 73 23 TRUE 0.18
uterine cancer RAS_12 PIK3R1 Any mutation 83 167 Signature overall -0.61 -1.33 0.05 1391.01 1.00 331 66 150 17 TRUE 1.08
colorectal cancer RAS_12 FAT1 Any mutation 10 44 Signature 10 -1.50 -2.78 -0.27 1260.56 1.00 16 7 41 3 FALSE 1.72
colorectal cancer RAS_12 FAT1 Any mutation 101 29 Signature 15 -1.56 -2.79 -0.48 1495.80 1.00 266 99 27 2 FALSE 1.99
colorectal cancer RAS_12 FAT1 Any mutation 283 66 Signature 1A -0.65 -1.25 -0.05 1420.09 1.00 524 268 51 15 FALSE 1.46
colorectal cancer RAS_12 FAT1 Any mutation 73 67 Signature 6 -0.83 -1.62 -0.11 1526.00 1.00 197 64 58 9 FALSE 1.53
non-small cell lung cancer RAS_12 FAT1 Any mutation 13 16 Signature 13 0.08 -0.94 1.03 1251.98 1.00 73 11 14 2 FALSE 0.06
non-small cell lung cancer RAS_12 FAT1 Any mutation 57 16 Signature 18 0.54 -0.25 1.36 1479.51 1.00 86 48 7 9 FALSE 0.73
non-small cell lung cancer RAS_12 FAT1 Any mutation 44 13 Signature 1A 0.34 -0.52 1.24 1688.32 1.00 216 40 9 4 FALSE 0.34
non-small cell lung cancer RAS_12 FAT1 Any mutation 81 38 Signature 2 0.13 -0.58 0.79 1323.80 1.00 221 71 28 10 FALSE 0.16
non-small cell lung cancer RAS_12 FAT1 Any mutation 14 11 Signature 20 0.53 -0.38 1.49 1321.92 1.00 57 10 7 4 FALSE 0.55
non-small cell lung cancer RAS_12 FAT1 Any mutation 50 13 Signature 3 0.21 -0.64 1.06 1545.01 1.00 184 46 9 4 FALSE 0.19
non-small cell lung cancer RAS_12 FAT1 Any mutation 232 121 Signature 4 -0.44 -0.91 0.00 1555.84 1.00 390 205 94 27 FALSE 1.29
uterine cancer RAS_12 FAT1 Any mutation 19 14 Signature 15 -1.01 -2.99 0.54 1435.08 1.00 80 18 13 1 FALSE 0.59
uterine cancer RAS_12 FAT1 Any mutation 36 24 Signature 1A -0.92 -2.38 0.35 1368.56 1.00 165 34 22 2 FALSE 0.73
uterine cancer RAS_12 FAT1 Any mutation 13 37 Signature 6 0.08 -1.14 1.23 1400.82 1.00 65 8 32 5 FALSE 0.05
colorectal cancer RAS_12 FAT1 Any mutation 467 206 Signature overall -1.10 -2.36 0.11 1289.21 1.00 1003 438 177 29 FALSE 1.11
non-small cell lung cancer RAS_12 FAT1 Any mutation 491 228 Signature overall 0.20 -0.38 0.79 1465.41 1.00 1227 431 168 60 FALSE 0.29
uterine cancer RAS_12 FAT1 Any mutation 71 149 Signature overall -0.46 -2.17 1.28 1373.25 1.00 322 60 138 11 FALSE 0.23
colorectal cancer RAS_12 CIC Any mutation 102 19 Signature 15 -0.50 -1.32 0.33 1399.54 1.00 275 98 15 4 TRUE 0.63
colorectal cancer RAS_12 CIC Any mutation 280 58 Signature 1A -0.38 -0.93 0.17 1555.59 1.00 533 264 42 16 TRUE 0.76
colorectal cancer RAS_12 CIC Any mutation 73 43 Signature 6 -0.68 -1.53 0.03 1396.86 1.00 211 68 38 5 TRUE 1.07
colorectal cancer RAS_12 CIC Any mutation 455 120 Signature overall -0.51 -1.32 0.30 1464.10 1.00 1019 430 95 25 TRUE 0.70
colorectal cancer RAS_12 NCOR1 Any mutation 8 16 Signature 10 -1.10 -2.60 0.09 1398.93 1.00 17 7 15 1 FALSE 0.96
colorectal cancer RAS_12 NCOR1 Any mutation 101 22 Signature 15 -0.47 -1.42 0.36 1537.61 1.00 270 96 17 5 FALSE 0.50
colorectal cancer RAS_12 NCOR1 Any mutation 281 44 Signature 1A -0.76 -1.49 -0.10 1354.27 1.00 536 272 35 9 FALSE 1.47
colorectal cancer RAS_12 NCOR1 Any mutation 73 43 Signature 6 -0.73 -1.61 0.07 1066.31 1.00 211 67 37 6 FALSE 1.05
non-small cell lung cancer RAS_12 NCOR1 Any mutation 14 14 Signature 13 0.09 -1.19 1.35 1305.04 1.00 77 11 11 3 FALSE 0.05
non-small cell lung cancer RAS_12 NCOR1 Any mutation 79 11 Signature 2 -0.23 -1.44 0.93 1423.17 1.00 240 76 8 3 FALSE 0.15
non-small cell lung cancer RAS_12 NCOR1 Any mutation 231 36 Signature 4 -0.97 -1.92 -0.18 1519.27 1.00 442 226 31 5 FALSE 1.58
colorectal cancer RAS_12 NCOR1 Any mutation 463 125 Signature overall -0.75 -1.77 0.24 1526.31 1.00 1034 442 104 21 FALSE 0.81
non-small cell lung cancer RAS_12 NCOR1 Any mutation 324 61 Signature overall -0.39 -1.56 0.91 1497.23 1.00 759 313 50 11 FALSE 0.28
colorectal cancer RAS_12 POLE Any mutation 8 20 Signature 10 -1.46 -3.14 -0.12 1520.64 1.00 15 7 19 1 TRUE 1.21
colorectal cancer RAS_12 POLE Any mutation 101 19 Signature 15 -0.50 -1.63 0.54 1560.29 1.00 273 97 15 4 TRUE 0.45
colorectal cancer RAS_12 POLE Any mutation 280 36 Signature 1A -0.14 -0.83 0.56 1492.53 1.00 546 268 24 12 TRUE 0.16
colorectal cancer RAS_12 POLE Any mutation 74 54 Signature 6 -1.03 -1.92 -0.25 1308.51 1.00 199 68 48 6 TRUE 1.78
non-small cell lung cancer RAS_12 POLE Any mutation 80 19 Signature 2 0.19 -0.71 1.12 1384.34 1.00 233 74 13 6 TRUE 0.17
non-small cell lung cancer RAS_12 POLE Any mutation 230 49 Signature 4 -0.38 -1.03 0.21 1467.64 1.00 438 218 37 12 TRUE 0.64
non-small cell lung cancer RAS_12 POLE Any mutation 144 11 Signature R2 0.29 -0.78 1.48 1447.31 1.00 52 135 2 9 TRUE 0.21
uterine cancer RAS_12 POLE Any mutation 36 12 Signature 1A 0.34 -1.15 1.63 1367.97 1.00 175 33 9 3 TRUE 0.20
uterine cancer RAS_12 POLE Any mutation 13 20 Signature 6 0.18 -1.25 1.51 1300.91 1.00 74 10 17 3 TRUE 0.10
colorectal cancer RAS_12 POLE Any mutation 463 129 Signature overall -0.79 -2.09 0.40 1561.31 1.00 1033 440 106 23 TRUE 0.70
non-small cell lung cancer RAS_12 POLE Any mutation 454 79 Signature overall 0.03 -1.20 1.22 1545.63 1.00 723 427 52 27 TRUE 0.02
uterine cancer RAS_12 POLE Any mutation 51 89 Signature overall 0.26 -2.09 2.76 1443.53 1.00 260 43 81 8 TRUE 0.08
non-small cell lung cancer RAS_12 NOTCH2 Any mutation 79 15 Signature 2 -0.94 -2.08 0.08 1356.43 1.00 230 77 13 2 TRUE 1.04
non-small cell lung cancer RAS_12 NOTCH2 Any mutation 230 54 Signature 4 -0.92 -1.67 -0.27 1408.95 1.00 437 221 45 9 TRUE 1.99
non-small cell lung cancer RAS_12 NOTCH2 Any mutation 309 69 Signature overall -0.92 -2.23 0.26 1261.11 1.00 667 298 58 11 TRUE 0.90
colorectal cancer RAS_12 TGFBR2 Any mutation 102 11 Signature 15 -0.58 -1.69 0.45 1556.26 1.00 275 100 9 2 TRUE 0.52
colorectal cancer RAS_12 TGFBR2 Any mutation 280 48 Signature 1A -0.29 -0.95 0.30 1478.56 1.00 535 266 34 14 TRUE 0.44
colorectal cancer RAS_12 TGFBR2 Any mutation 72 43 Signature 6 -0.61 -1.46 0.15 1415.39 1.00 204 66 37 6 TRUE 0.88
colorectal cancer RAS_12 TGFBR2 Any mutation 454 102 Signature overall -0.48 -1.43 0.46 1577.55 1.00 1014 432 80 22 TRUE 0.50
colorectal cancer RAS_12 KMT2A Any mutation 9 22 Signature 10 -1.13 -2.52 0.07 1403.26 1.00 20 7 20 2 FALSE 1.05
colorectal cancer RAS_12 KMT2A Any mutation 101 19 Signature 15 -1.58 -3.14 -0.35 1531.74 1.00 269 100 18 1 FALSE 1.58
colorectal cancer RAS_12 KMT2A Any mutation 279 53 Signature 1A -0.19 -0.82 0.40 1197.11 1.00 535 262 36 17 FALSE 0.26
colorectal cancer RAS_12 KMT2A Any mutation 72 42 Signature 6 -1.42 -2.54 -0.45 1330.60 1.00 210 69 39 3 FALSE 2.11
non-small cell lung cancer RAS_12 KMT2A Any mutation 79 23 Signature 2 -0.14 -0.94 0.66 1593.59 1.00 230 73 17 6 FALSE 0.13
non-small cell lung cancer RAS_12 KMT2A Any mutation 230 37 Signature 4 -0.35 -1.09 0.31 1468.14 1.00 445 221 28 9 FALSE 0.52
uterine cancer RAS_12 KMT2A Any mutation 36 13 Signature 1A -0.46 -2.18 1.01 1495.44 1.00 172 34 11 2 FALSE 0.23
uterine cancer RAS_12 KMT2A Any mutation 13 14 Signature 6 -2.46 -6.92 0.00 1501.12 1.00 71 13 14 0 FALSE 0.79
colorectal cancer RAS_12 KMT2A Any mutation 461 136 Signature overall -1.06 -2.25 0.01 1387.04 1.00 1034 438 113 23 FALSE 1.15
non-small cell lung cancer RAS_12 KMT2A Any mutation 309 60 Signature overall -0.24 -1.27 0.82 1521.54 1.00 675 294 45 15 FALSE 0.17
uterine cancer RAS_12 KMT2A Any mutation 51 81 Signature overall -0.92 -4.03 1.77 1501.76 1.00 261 47 77 4 FALSE 0.28
non-small cell lung cancer RAS_12 PAK7 Any mutation 230 69 Signature 4 -0.62 -1.24 -0.05 1324.16 1.00 425 215 54 15 FALSE 1.38
non-small cell lung cancer RAS_12 PAK7 Any mutation 230 69 Signature overall -0.47 -4.39 3.57 1210.89 1.00 425 215 54 15 FALSE 0.10
non-small cell lung cancer RAS_12 STAG2 Any mutation 79 16 Signature 2 0.08 -0.84 0.90 1445.19 1.00 234 75 12 4 TRUE 0.07
non-small cell lung cancer RAS_12 STAG2 Any mutation 231 43 Signature 4 0.18 -0.43 0.76 1265.66 1.00 448 215 27 16 TRUE 0.27
non-small cell lung cancer RAS_12 STAG2 Any mutation 310 59 Signature overall 0.13 -0.88 1.10 1347.82 1.00 682 290 39 20 TRUE 0.09
non-small cell lung cancer RAS_12 TERT Any mutation 80 23 Signature 2 0.76 -0.07 1.65 1395.23 1.00 233 69 12 11 TRUE 1.05
non-small cell lung cancer RAS_12 TERT Any mutation 231 54 Signature 4 -0.01 -0.61 0.53 1568.53 1.00 438 215 38 16 TRUE 0.01
non-small cell lung cancer RAS_12 TERT Any mutation 311 77 Signature overall 0.37 -0.87 1.77 1399.20 1.00 671 284 50 27 TRUE 0.23
colorectal cancer RAS_12 BRCA2 Any mutation 8 37 Signature 10 -3.05 -5.87 -1.15 1660.14 1.00 17 8 37 0 TRUE 1.99
colorectal cancer RAS_12 BRCA2 Any mutation 101 17 Signature 15 -0.87 -2.23 0.29 1617.97 1.00 275 98 14 3 TRUE 0.75
colorectal cancer RAS_12 BRCA2 Any mutation 280 50 Signature 1A -0.48 -1.16 0.15 1188.11 1.00 537 267 37 13 TRUE 0.81
colorectal cancer RAS_12 BRCA2 Any mutation 72 62 Signature 6 -1.96 -3.17 -0.94 1181.00 1.00 199 69 59 3 TRUE 3.13
non-small cell lung cancer RAS_12 BRCA2 Any mutation 13 13 Signature 13 -1.37 -3.79 0.06 1328.12 1.00 74 13 13 0 TRUE 0.79
non-small cell lung cancer RAS_12 BRCA2 Any mutation 79 15 Signature 2 -1.24 -2.94 -0.09 1186.25 1.00 232 78 14 1 TRUE 1.05
non-small cell lung cancer RAS_12 BRCA2 Any mutation 231 55 Signature 4 -0.35 -0.99 0.23 1400.12 1.00 439 215 39 16 TRUE 0.57
uterine cancer RAS_12 BRCA2 Any mutation 36 15 Signature 1A -0.07 -1.49 1.22 1459.15 1.00 171 33 12 3 TRUE 0.04
uterine cancer RAS_12 BRCA2 Any mutation 13 22 Signature 6 -2.94 -7.38 -0.50 1524.40 1.00 69 13 22 0 TRUE 0.98
colorectal cancer RAS_12 BRCA2 Any mutation 461 166 Signature overall -1.55 -3.31 0.03 1587.88 1.00 1028 442 147 19 TRUE 1.26
non-small cell lung cancer RAS_12 BRCA2 Any mutation 323 83 Signature overall -0.98 -2.53 0.16 1430.99 1.00 745 306 66 17 TRUE 0.83
uterine cancer RAS_12 BRCA2 Any mutation 51 102 Signature overall -0.98 -3.83 2.08 1502.17 1.00 255 46 97 5 TRUE 0.30
colorectal cancer RAS_12 NOTCH3 Any mutation 101 27 Signature 15 -0.39 -1.24 0.47 1582.35 1.00 269 94 20 7 TRUE 0.43
colorectal cancer RAS_12 NOTCH3 Any mutation 280 70 Signature 1A -0.87 -1.49 -0.30 1545.56 1.00 520 267 57 13 TRUE 2.41
colorectal cancer RAS_12 NOTCH3 Any mutation 73 72 Signature 6 -1.49 -2.46 -0.69 1561.98 1.00 190 69 68 4 TRUE 3.10
non-small cell lung cancer RAS_12 NOTCH3 Any mutation 57 11 Signature 18 0.07 -0.73 1.01 1406.85 1.00 89 51 5 6 TRUE 0.06
non-small cell lung cancer RAS_12 NOTCH3 Any mutation 79 15 Signature 2 -0.28 -1.16 0.47 1490.58 1.00 234 76 12 3 TRUE 0.30
non-small cell lung cancer RAS_12 NOTCH3 Any mutation 230 48 Signature 4 -0.34 -0.99 0.26 1442.62 1.00 440 219 37 11 TRUE 0.55
colorectal cancer RAS_12 NOTCH3 Any mutation 454 169 Signature overall -0.91 -2.00 0.07 1506.26 1.00 979 430 145 24 TRUE 1.11
non-small cell lung cancer RAS_12 NOTCH3 Any mutation 366 74 Signature overall -0.18 -0.95 0.58 1458.09 1.00 763 346 54 20 TRUE 0.19
colorectal cancer RAS_12 NOTCH4 Any mutation 97 18 Signature 15 -0.65 -1.62 0.23 1637.94 1.00 267 94 15 3 TRUE 0.80
colorectal cancer RAS_12 NOTCH4 Any mutation 270 43 Signature 1A -0.59 -1.26 0.00 1310.50 1.00 523 260 33 10 TRUE 1.16
colorectal cancer RAS_12 NOTCH4 Any mutation 70 41 Signature 6 -0.59 -1.37 0.12 1410.99 1.00 204 64 35 6 TRUE 0.92
non-small cell lung cancer RAS_12 NOTCH4 Any mutation 230 74 Signature 4 -0.40 -0.95 0.14 828.44 1.00 423 211 55 19 TRUE 0.78
colorectal cancer RAS_12 NOTCH4 Any mutation 437 102 Signature overall -0.60 -1.45 0.26 1499.58 1.00 994 418 83 19 TRUE 0.79
non-small cell lung cancer RAS_12 NOTCH4 Any mutation 230 74 Signature overall -0.43 -4.73 3.80 1348.80 1.00 423 211 55 19 TRUE 0.08
non-small cell lung cancer RAS_12 KEAP1 Any mutation 13 20 Signature 13 -0.10 -1.17 0.80 1554.89 1.00 67 11 18 2 FALSE 0.08
non-small cell lung cancer RAS_12 KEAP1 Any mutation 17 12 Signature 14 0.05 -0.99 0.98 1531.89 1.00 30 14 9 3 FALSE 0.04
non-small cell lung cancer RAS_12 KEAP1 Any mutation 20 16 Signature 15 0.35 -0.56 1.26 1311.33 1.00 105 16 12 4 FALSE 0.36
non-small cell lung cancer RAS_12 KEAP1 Any mutation 8 12 Signature 16 0.12 -0.89 1.16 1490.44 1.00 42 6 10 2 FALSE 0.09
non-small cell lung cancer RAS_12 KEAP1 Any mutation 58 34 Signature 18 -0.09 -0.81 0.55 1296.13 1.00 71 47 23 11 FALSE 0.10
non-small cell lung cancer RAS_12 KEAP1 Any mutation 15 11 Signature 19 0.41 -0.44 1.34 1502.14 1.00 41 11 7 4 FALSE 0.41
non-small cell lung cancer RAS_12 KEAP1 Any mutation 44 27 Signature 1A 0.51 -0.26 1.30 1498.08 1.00 205 36 19 8 FALSE 0.74
non-small cell lung cancer RAS_12 KEAP1 Any mutation 79 55 Signature 2 -0.09 -0.73 0.51 1621.04 1.00 205 67 43 12 FALSE 0.11
non-small cell lung cancer RAS_12 KEAP1 Any mutation 13 13 Signature 20 0.24 -0.70 1.18 1465.12 1.00 54 10 10 3 FALSE 0.21
non-small cell lung cancer RAS_12 KEAP1 Any mutation 50 31 Signature 3 0.50 -0.25 1.17 1592.90 1.00 172 40 21 10 FALSE 0.77
non-small cell lung cancer RAS_12 KEAP1 Any mutation 232 175 Signature 4 -0.20 -0.56 0.15 1505.19 1.00 352 182 125 50 FALSE 0.57
non-small cell lung cancer RAS_12 KEAP1 Any mutation 21 14 Signature 7 -0.32 -1.40 0.61 1483.38 1.00 75 20 13 1 FALSE 0.27
non-small cell lung cancer RAS_12 KEAP1 Any mutation 145 45 Signature R2 0.08 -0.56 0.71 1481.89 1.00 41 114 14 31 FALSE 0.10
non-small cell lung cancer RAS_12 KEAP1 Any mutation 17 11 Signature U1 1.14 0.19 2.11 1516.03 1.00 90 10 4 7 FALSE 1.71
non-small cell lung cancer RAS_12 KEAP1 Any mutation 732 476 Signature overall 0.19 -0.23 0.63 1474.95 1.00 1550 584 328 148 FALSE 0.40
non-small cell lung cancer RAS_12 KDM5C Any mutation 79 15 Signature 2 -0.21 -1.68 0.73 1451.52 1.00 233 77 13 2 FALSE 0.13
non-small cell lung cancer RAS_12 KDM5C Any mutation 231 41 Signature 4 0.46 -0.15 1.07 1492.36 1.00 451 212 22 19 FALSE 0.83
non-small cell lung cancer RAS_12 KDM5C Any mutation 310 56 Signature overall 0.11 -1.30 1.30 1502.04 1.00 684 289 35 21 FALSE 0.06
non-small cell lung cancer RAS_12 CDKN2A Any mutation 13 12 Signature 13 -0.97 -2.59 0.38 1351.75 1.00 73 13 12 0 TRUE 0.69
non-small cell lung cancer RAS_12 CDKN2A Any mutation 20 11 Signature 15 -0.54 -2.02 0.71 1470.19 1.00 106 19 10 1 TRUE 0.37
non-small cell lung cancer RAS_12 CDKN2A Any mutation 44 18 Signature 1A 0.47 -0.56 1.44 1304.34 1.00 210 38 12 6 TRUE 0.45
non-small cell lung cancer RAS_12 CDKN2A Any mutation 79 22 Signature 2 -1.19 -2.49 -0.16 1435.31 1.00 225 78 21 1 TRUE 1.26
non-small cell lung cancer RAS_12 CDKN2A Any mutation 51 20 Signature 3 0.20 -0.73 1.06 1289.42 1.00 179 45 14 6 TRUE 0.16
non-small cell lung cancer RAS_12 CDKN2A Any mutation 233 90 Signature 4 -0.58 -1.10 -0.07 1481.75 1.00 407 213 70 20 TRUE 1.57
non-small cell lung cancer RAS_12 CDKN2A Any mutation 144 11 Signature R2 0.04 -0.96 1.11 1675.73 1.00 52 135 2 9 TRUE 0.03
pancreatic cancer RAS_12 CDKN2A Any mutation 117 30 Signature 11 1.30 0.00 2.67 1394.56 1.00 9 88 1 29 TRUE 1.31
pancreatic cancer RAS_12 CDKN2A Any mutation 110 27 Signature 15 0.48 -0.53 1.51 1514.60 1.00 19 88 5 22 TRUE 0.46
pancreatic cancer RAS_12 CDKN2A Any mutation 12 11 Signature 17 0.27 -0.96 1.44 1402.71 1.00 33 10 9 2 TRUE 0.18
pancreatic cancer RAS_12 CDKN2A Any mutation 205 67 Signature 1A 1.11 0.38 1.91 1630.92 1.00 44 145 7 60 TRUE 2.27
pancreatic cancer RAS_12 CDKN2A Any mutation 83 23 Signature 3 1.88 0.68 3.40 1458.78 1.00 19 60 0 23 TRUE 2.25
pancreatic cancer RAS_12 CDKN2A Any mutation 62 25 Signature 4 2.10 0.90 3.63 1380.94 1.00 12 37 0 25 TRUE 2.53
pancreatic cancer RAS_12 CDKN2A Any mutation 54 26 Signature 6 2.43 1.17 4.04 1542.89 1.00 20 28 0 26 TRUE 3.15
pancreatic cancer RAS_12 CDKN2A Any mutation 49 11 Signature 8 1.43 0.06 2.99 1475.85 1.00 3 38 0 11 TRUE 1.17
non-small cell lung cancer RAS_12 CDKN2A Any mutation 584 184 Signature overall -0.37 -1.22 0.37 1390.06 1.00 1252 541 141 43 TRUE 0.44
pancreatic cancer RAS_12 CDKN2A Any mutation 692 220 Signature overall 1.39 0.51 2.42 1422.67 1.00 159 494 22 198 TRUE 2.48
non-small cell lung cancer RAS_12 EPHB1 Any mutation 79 17 Signature 2 -0.37 -1.44 0.69 1640.51 1.00 233 75 13 4 FALSE 0.31
non-small cell lung cancer RAS_12 EPHB1 Any mutation 232 79 Signature 4 -0.66 -1.25 -0.12 1420.38 1.00 419 216 63 16 FALSE 1.63
non-small cell lung cancer RAS_12 EPHB1 Any mutation 311 96 Signature overall -0.49 -1.80 0.99 1633.28 1.00 652 291 76 20 FALSE 0.32
uterine cancer RAS_12 PPP2R1A Any mutation 19 20 Signature 15 -1.16 -2.65 -0.09 1378.71 1.00 72 18 19 1 FALSE 1.15
uterine cancer RAS_12 PPP2R1A Any mutation 36 25 Signature 1A -0.76 -1.87 0.25 1420.89 1.00 163 33 22 3 FALSE 0.76
uterine cancer RAS_12 PPP2R1A Any mutation 11 14 Signature 3 -0.84 -2.06 0.29 1285.74 1.00 22 9 12 2 FALSE 0.77
uterine cancer RAS_12 PPP2R1A Any mutation 13 17 Signature 6 -0.69 -1.97 0.54 1140.86 1.00 74 11 15 2 FALSE 0.54
uterine cancer RAS_12 PPP2R1A Any mutation 80 96 Signature overall -0.91 -1.92 0.04 1451.78 1.00 363 72 88 8 FALSE 1.11
colorectal cancer RAS_12 ERBB3 Any mutation 101 18 Signature 15 -0.45 -1.34 0.33 1421.72 1.00 269 98 15 3 TRUE 0.53
colorectal cancer RAS_12 ERBB3 Any mutation 280 46 Signature 1A -0.41 -1.01 0.14 1091.12 1.00 538 269 35 11 TRUE 0.76
colorectal cancer RAS_12 ERBB3 Any mutation 72 34 Signature 6 -0.04 -0.74 0.70 1599.90 1.00 219 63 25 9 TRUE 0.04
colorectal cancer RAS_12 ERBB3 Any mutation 453 98 Signature overall -0.29 -1.06 0.50 1066.15 1.00 1026 430 75 23 TRUE 0.33
colorectal cancer RAS_12 SMAD4 Any mutation 8 17 Signature 10 0.13 -0.64 0.81 1377.83 1.00 17 5 14 3 TRUE 0.14
colorectal cancer RAS_12 SMAD4 Any mutation 102 60 Signature 15 0.28 -0.18 0.76 1525.76 1.00 248 82 40 20 TRUE 0.60
colorectal cancer RAS_12 SMAD4 Any mutation 8 11 Signature 17 0.11 -0.71 0.86 1460.43 1.00 29 6 9 2 TRUE 0.11
colorectal cancer RAS_12 SMAD4 Any mutation 20 12 Signature 19 0.36 -0.35 1.08 1516.00 1.00 20 14 6 6 TRUE 0.48
colorectal cancer RAS_12 SMAD4 Any mutation 286 122 Signature 1A 0.16 -0.21 0.54 1510.36 1.00 492 241 77 45 TRUE 0.42
colorectal cancer RAS_12 SMAD4 Any mutation 36 11 Signature 2 0.02 -0.70 0.67 1406.28 1.00 39 32 7 4 TRUE 0.02
colorectal cancer RAS_12 SMAD4 Any mutation 73 57 Signature 6 0.11 -0.45 0.62 1418.86 1.00 203 59 43 14 TRUE 0.15
colorectal cancer RAS_12 SMAD4 Any mutation 15 11 Signature 7 0.46 -0.27 1.23 1524.81 1.00 20 9 5 6 TRUE 0.64
non-small cell lung cancer RAS_12 SMAD4 Any mutation 44 17 Signature 1A -0.17 -1.45 0.90 1580.06 1.00 209 42 15 2 TRUE 0.11
non-small cell lung cancer RAS_12 SMAD4 Any mutation 79 21 Signature 2 0.76 -0.12 1.65 1391.13 1.00 234 69 11 10 TRUE 1.03
non-small cell lung cancer RAS_12 SMAD4 Any mutation 230 16 Signature 4 -0.47 -1.54 0.42 1620.77 1.00 459 227 13 3 TRUE 0.45
pancreatic cancer RAS_12 SMAD4 Any mutation 115 25 Signature 11 0.30 -0.65 1.30 1490.86 1.00 9 91 1 24 TRUE 0.27
pancreatic cancer RAS_12 SMAD4 Any mutation 109 31 Signature 15 0.35 -0.43 1.20 1376.57 1.00 20 82 4 27 TRUE 0.39
pancreatic cancer RAS_12 SMAD4 Any mutation 12 12 Signature 17 -0.97 -2.35 0.14 1384.92 1.00 31 12 12 0 TRUE 0.93
pancreatic cancer RAS_12 SMAD4 Any mutation 201 56 Signature 1A 0.00 -0.62 0.64 1432.88 1.00 40 157 12 44 TRUE 0.00
pancreatic cancer RAS_12 SMAD4 Any mutation 33 12 Signature 2 -0.28 -1.32 0.71 1546.69 1.00 8 26 5 7 TRUE 0.23
pancreatic cancer RAS_12 SMAD4 Any mutation 80 24 Signature 3 0.38 -0.50 1.33 1293.88 1.00 16 59 3 21 TRUE 0.41
pancreatic cancer RAS_12 SMAD4 Any mutation 61 15 Signature 4 0.37 -0.61 1.40 1351.78 1.00 11 47 1 14 TRUE 0.34
pancreatic cancer RAS_12 SMAD4 Any mutation 54 15 Signature 6 -0.17 -1.07 0.76 1553.84 1.00 15 44 5 10 TRUE 0.15
pancreatic cancer RAS_12 SMAD4 Any mutation 50 15 Signature 8 0.53 -0.56 1.65 1514.09 1.00 3 35 0 15 TRUE 0.45
colorectal cancer RAS_12 SMAD4 Any mutation 548 301 Signature overall 0.20 -0.27 0.66 1430.65 1.00 1068 448 201 100 TRUE 0.41
non-small cell lung cancer RAS_12 SMAD4 Any mutation 353 54 Signature overall 0.04 -1.17 1.08 1489.94 1.00 902 338 39 15 TRUE 0.03
pancreatic cancer RAS_12 SMAD4 Any mutation 715 205 Signature overall 0.06 -0.63 0.71 1460.06 1.00 153 553 43 162 TRUE 0.07
colorectal cancer RAS_12 ATM Any mutation 10 39 Signature 10 -0.92 -2.08 0.21 1359.04 1.00 16 6 35 4 TRUE 0.93
colorectal cancer RAS_12 ATM Any mutation 102 32 Signature 15 -0.58 -1.51 0.24 1487.08 1.00 262 96 26 6 TRUE 0.69
colorectal cancer RAS_12 ATM Any mutation 282 77 Signature 1A -0.04 -0.58 0.45 1473.17 1.00 522 256 51 26 TRUE 0.06
colorectal cancer RAS_12 ATM Any mutation 73 48 Signature 6 -1.04 -2.00 -0.16 1674.91 1.00 204 68 43 5 TRUE 1.62
non-small cell lung cancer RAS_12 ATM Any mutation 13 12 Signature 13 0.77 -0.33 1.85 1398.86 1.00 76 10 9 3 TRUE 0.80
non-small cell lung cancer RAS_12 ATM Any mutation 57 11 Signature 18 0.70 -0.24 1.64 1521.48 1.00 89 51 5 6 TRUE 0.84
non-small cell lung cancer RAS_12 ATM Any mutation 81 27 Signature 2 0.88 0.18 1.55 1293.52 1.00 231 69 15 12 TRUE 1.84
non-small cell lung cancer RAS_12 ATM Any mutation 50 13 Signature 3 0.58 -0.43 1.55 1418.55 1.00 184 46 9 4 TRUE 0.63
non-small cell lung cancer RAS_12 ATM Any mutation 241 95 Signature 4 0.74 0.32 1.14 1315.82 1.00 429 195 49 46 TRUE 3.24
non-small cell lung cancer RAS_12 ATM Any mutation 145 25 Signature R2 0.52 -0.27 1.31 1552.77 1.00 48 126 6 19 TRUE 0.71
non-small cell lung cancer RAS_12 ATM Any mutation 11 12 Signature U2 1.59 0.56 2.76 1322.94 1.00 31 4 5 7 TRUE 2.31
uterine cancer RAS_12 ATM Any mutation 36 23 Signature 1A -0.58 -1.95 0.61 1578.16 1.00 167 33 20 3 TRUE 0.44
uterine cancer RAS_12 ATM Any mutation 14 24 Signature 6 -0.84 -2.38 0.52 1320.48 1.00 70 12 22 2 TRUE 0.59
colorectal cancer RAS_12 ATM Any mutation 467 196 Signature overall -0.65 -1.84 0.49 1333.84 1.00 1004 426 155 41 TRUE 0.56
non-small cell lung cancer RAS_12 ATM Any mutation 598 195 Signature overall 0.82 0.15 1.53 1466.28 1.00 1088 501 98 97 TRUE 1.73
uterine cancer RAS_12 ATM Any mutation 56 121 Signature overall -0.85 -2.55 0.80 1353.81 1.00 261 48 113 8 TRUE 0.48
non-small cell lung cancer RAS_12 RB1 Any mutation 13 11 Signature 13 -0.79 -1.71 0.33 1551.19 1.00 78 11 9 2 TRUE 0.91
non-small cell lung cancer RAS_12 RB1 Any mutation 57 11 Signature 18 -0.87 -1.76 0.00 1347.19 1.00 85 54 8 3 TRUE 1.33
non-small cell lung cancer RAS_12 RB1 Any mutation 44 16 Signature 1A -0.91 -1.83 -0.01 1444.03 1.00 208 42 14 2 TRUE 1.32
non-small cell lung cancer RAS_12 RB1 Any mutation 79 28 Signature 2 -1.01 -1.84 -0.23 1593.61 1.00 220 76 25 3 TRUE 1.94
non-small cell lung cancer RAS_12 RB1 Any mutation 50 18 Signature 3 -1.24 -2.25 -0.38 1509.64 1.00 175 50 18 0 TRUE 2.06
non-small cell lung cancer RAS_12 RB1 Any mutation 230 67 Signature 4 -1.03 -1.65 -0.47 1535.50 1.00 419 220 57 10 TRUE 3.16
non-small cell lung cancer RAS_12 RB1 Any mutation 473 151 Signature overall -0.97 -1.60 -0.32 1516.71 1.00 1185 453 131 20 TRUE 2.53
cancer of unknown primary RAS_12 KMT2D Any mutation 32 18 Signature 1A -1.50 -2.89 -0.31 1540.02 1.00 70 30 16 2 FALSE 1.61
cancer of unknown primary RAS_12 KMT2D Any mutation 19 15 Signature 4 -1.28 -2.80 0.00 1523.59 1.00 50 17 13 2 FALSE 1.14
colorectal cancer RAS_12 KMT2D Any mutation 8 19 Signature 10 -1.17 -2.48 -0.13 1461.56 1.00 16 7 18 1 FALSE 1.29
colorectal cancer RAS_12 KMT2D Any mutation 102 55 Signature 15 -0.86 -1.58 -0.18 1359.20 1.00 259 94 47 8 FALSE 1.86
colorectal cancer RAS_12 KMT2D Any mutation 288 128 Signature 1A -0.61 -1.05 -0.21 1408.61 1.00 505 259 99 29 FALSE 2.42
colorectal cancer RAS_12 KMT2D Any mutation 82 142 Signature 6 -0.80 -1.30 -0.29 1477.69 1.00 169 62 122 20 FALSE 2.68
non-small cell lung cancer RAS_12 KMT2D Any mutation 13 16 Signature 13 -1.30 -2.78 -0.03 1304.07 1.00 70 13 16 0 FALSE 1.19
non-small cell lung cancer RAS_12 KMT2D Any mutation 57 16 Signature 18 -0.95 -1.98 -0.02 1345.96 1.00 82 54 13 3 FALSE 1.22
non-small cell lung cancer RAS_12 KMT2D Any mutation 44 22 Signature 1A -0.82 -1.98 0.28 1163.67 1.00 205 42 20 2 FALSE 0.83
non-small cell lung cancer RAS_12 KMT2D Any mutation 80 46 Signature 2 -0.19 -0.92 0.48 1492.28 1.00 216 69 35 11 FALSE 0.23
non-small cell lung cancer RAS_12 KMT2D Any mutation 50 13 Signature 3 -0.98 -2.33 0.18 1609.79 1.00 181 49 12 1 FALSE 0.92
non-small cell lung cancer RAS_12 KMT2D Any mutation 232 129 Signature 4 -0.69 -1.13 -0.25 1515.05 1.00 391 205 102 27 FALSE 2.70
non-small cell lung cancer RAS_12 KMT2D Any mutation 144 13 Signature R2 -0.24 -1.13 0.68 1401.02 1.00 51 134 3 10 FALSE 0.22
uterine cancer RAS_12 KMT2D Any mutation 20 27 Signature 15 -0.09 -1.11 0.86 1404.28 1.00 73 14 21 6 FALSE 0.07
uterine cancer RAS_12 KMT2D Any mutation 36 61 Signature 1A -0.72 -1.54 0.06 1289.81 1.00 140 30 55 6 FALSE 1.05
uterine cancer RAS_12 KMT2D Any mutation 7 13 Signature 20 -0.88 -2.23 0.37 1397.42 1.00 24 6 12 1 FALSE 0.72
uterine cancer RAS_12 KMT2D Any mutation 14 63 Signature 6 -0.77 -1.76 0.14 1561.07 1.00 45 9 58 5 FALSE 0.98
cancer of unknown primary RAS_12 KMT2D Any mutation 59 76 Signature overall -1.54 -2.90 -0.31 1518.49 1.00 165 54 71 5 FALSE 1.68
colorectal cancer RAS_12 KMT2D Any mutation 480 344 Signature overall -0.85 -1.68 -0.07 1326.03 1.00 949 422 286 58 FALSE 1.52
non-small cell lung cancer RAS_12 KMT2D Any mutation 620 255 Signature overall -0.73 -1.46 -0.01 1385.53 1.00 1196 566 201 54 FALSE 1.33
uterine cancer RAS_12 KMT2D Any mutation 83 233 Signature overall -0.71 -1.56 0.16 1488.66 1.00 311 62 212 21 FALSE 0.96
colorectal cancer RAS_12 TSC2 Any mutation 101 11 Signature 15 0.27 -0.81 1.43 1331.51 1.00 278 96 6 5 TRUE 0.20
colorectal cancer RAS_12 TSC2 Any mutation 281 36 Signature 1A -0.32 -1.03 0.34 1406.47 1.00 545 271 26 10 TRUE 0.44
colorectal cancer RAS_12 TSC2 Any mutation 72 44 Signature 6 -0.94 -1.95 -0.09 1550.72 1.00 208 68 40 4 TRUE 1.34
colorectal cancer RAS_12 TSC2 Any mutation 454 91 Signature overall -0.35 -1.66 0.95 1444.02 1.00 1031 435 72 19 TRUE 0.23
colorectal cancer RAS_12 APC Any mutation 16 94 Signature 10 -0.09 -0.77 0.65 1510.42 1.00 3 0 78 16 TRUE 0.09
colorectal cancer RAS_12 APC Any mutation 27 39 Signature 11 -0.05 -0.79 0.64 1444.71 1.00 1 9 21 18 TRUE 0.05
colorectal cancer RAS_12 APC Any mutation 13 25 Signature 14 0.40 -0.35 1.19 1453.62 1.00 2 1 13 12 TRUE 0.53
colorectal cancer RAS_12 APC Any mutation 156 469 Signature 15 0.35 -0.06 0.80 1402.14 1.00 67 16 329 140 TRUE 0.97
colorectal cancer RAS_12 APC Any mutation 11 46 Signature 17 -0.31 -1.06 0.40 1408.69 1.00 11 4 39 7 TRUE 0.38
colorectal cancer RAS_12 APC Any mutation 23 63 Signature 18 -0.13 -0.83 0.54 1475.12 1.00 3 5 45 18 TRUE 0.15
colorectal cancer RAS_12 APC Any mutation 24 38 Signature 19 -0.17 -0.86 0.50 1500.96 1.00 8 10 24 14 TRUE 0.21
colorectal cancer RAS_12 APC Any mutation 406 962 Signature 1A 0.10 -0.19 0.39 1541.34 1.00 149 72 628 334 TRUE 0.30
colorectal cancer RAS_12 APC Any mutation 12 22 Signature 1B 0.40 -0.37 1.16 1380.88 1.00 7 1 11 11 TRUE 0.52
colorectal cancer RAS_12 APC Any mutation 51 95 Signature 2 0.41 -0.19 1.04 1423.26 1.00 11 6 50 45 TRUE 0.70
colorectal cancer RAS_12 APC Any mutation 13 34 Signature 20 -0.02 -0.80 0.73 1472.09 1.00 5 3 24 10 TRUE 0.02
colorectal cancer RAS_12 APC Any mutation 11 25 Signature 21 0.41 -0.34 1.17 1619.76 1.00 10 0 14 11 TRUE 0.52
colorectal cancer RAS_12 APC Any mutation 19 42 Signature 3 0.20 -0.48 0.90 1672.84 1.00 8 3 26 16 TRUE 0.25
colorectal cancer RAS_12 APC Any mutation 22 49 Signature 4 0.03 -0.67 0.69 1563.85 1.00 6 5 32 17 TRUE 0.03
colorectal cancer RAS_12 APC Any mutation 109 355 Signature 6 0.28 -0.14 0.74 1295.76 1.00 79 16 262 93 TRUE 0.65
colorectal cancer RAS_12 APC Any mutation 21 40 Signature 7 0.34 -0.34 1.00 1322.49 1.00 9 3 22 18 TRUE 0.50
colorectal cancer RAS_12 APC Any mutation 19 30 Signature 8 0.47 -0.26 1.16 1441.21 1.00 1 2 13 17 TRUE 0.71
colorectal cancer RAS_12 APC Any mutation 22 20 Signature R2 0.48 -0.25 1.25 1367.21 1.00 3 6 4 16 TRUE 0.69
colorectal cancer RAS_12 APC Any mutation 10 14 Signature U1 0.05 -0.78 0.83 1444.69 1.00 2 4 8 6 TRUE 0.04
non-small cell lung cancer RAS_12 APC Any mutation 44 13 Signature 1A -0.38 -1.45 0.67 1353.94 1.00 211 42 11 2 TRUE 0.33
non-small cell lung cancer RAS_12 APC Any mutation 82 23 Signature 2 -0.10 -0.88 0.72 1532.65 1.00 229 75 16 7 TRUE 0.09
non-small cell lung cancer RAS_12 APC Any mutation 230 50 Signature 4 -0.75 -1.47 -0.06 1491.59 1.00 434 222 42 8 TRUE 1.48
uterine cancer RAS_12 APC Any mutation 36 18 Signature 1A -0.53 -2.04 0.74 1556.66 1.00 172 34 16 2 TRUE 0.33
uterine cancer RAS_12 APC Any mutation 13 15 Signature 6 -0.08 -1.74 1.36 1557.62 1.00 76 11 13 2 TRUE 0.04
colorectal cancer RAS_12 APC Any mutation 985 2462 Signature overall 0.16 -0.19 0.51 1517.04 1.00 385 166 1643 819 TRUE 0.45
non-small cell lung cancer RAS_12 APC Any mutation 356 86 Signature overall -0.40 -1.26 0.41 1310.73 1.00 874 339 69 17 TRUE 0.45
uterine cancer RAS_12 APC Any mutation 53 96 Signature overall 0.02 -2.18 2.30 1593.20 1.00 265 45 88 8 TRUE 0.01
colorectal cancer RAS_12 ERBB2 Any mutation 279 47 Signature 1A -0.93 -1.66 -0.24 1483.64 1.00 532 271 39 8 TRUE 1.98
colorectal cancer RAS_12 ERBB2 Any mutation 72 29 Signature 6 -0.81 -1.73 0.06 1504.16 1.00 218 68 25 4 TRUE 1.11
non-small cell lung cancer RAS_12 ERBB2 Any mutation 44 15 Signature 1A -1.76 -3.53 -0.35 1393.17 1.00 208 43 14 1 TRUE 1.52
non-small cell lung cancer RAS_12 ERBB2 Any mutation 79 12 Signature 2 -2.05 -3.88 -0.60 1494.64 1.00 233 79 12 0 TRUE 1.81
non-small cell lung cancer RAS_12 ERBB2 Any mutation 230 19 Signature 4 -1.80 -3.28 -0.58 1440.54 1.00 457 228 17 2 TRUE 1.99
colorectal cancer RAS_12 ERBB2 Any mutation 351 76 Signature overall -0.85 -2.11 0.39 1562.84 1.00 750 339 64 12 TRUE 0.73
non-small cell lung cancer RAS_12 ERBB2 Any mutation 353 46 Signature overall -1.84 -3.36 -0.52 1462.96 1.00 898 350 43 3 TRUE 1.92
uterine cancer RAS_12 JAK1 Any mutation 20 14 Signature 15 0.53 -0.62 1.60 1486.62 1.00 83 16 10 4 TRUE 0.47
uterine cancer RAS_12 JAK1 Any mutation 38 35 Signature 1A 0.39 -0.40 1.14 1593.05 1.00 159 30 27 8 TRUE 0.47
uterine cancer RAS_12 JAK1 Any mutation 14 42 Signature 6 0.30 -0.67 1.31 1310.81 1.00 59 8 36 6 TRUE 0.26
uterine cancer RAS_12 JAK1 Any mutation 74 117 Signature overall 0.42 -0.66 1.57 1364.75 1.00 325 54 97 20 TRUE 0.34
colorectal cancer RAS_12 ARID2 Any mutation 8 16 Signature 10 -0.61 -1.96 0.58 1478.70 1.00 17 6 14 2 FALSE 0.47
colorectal cancer RAS_12 ARID2 Any mutation 101 19 Signature 15 -0.72 -1.90 0.30 1550.64 1.00 271 98 16 3 FALSE 0.74
colorectal cancer RAS_12 ARID2 Any mutation 280 42 Signature 1A -0.12 -0.79 0.53 1643.65 1.00 542 266 28 14 FALSE 0.15
colorectal cancer RAS_12 ARID2 Any mutation 72 27 Signature 6 -0.62 -1.67 0.28 1466.32 1.00 218 68 23 4 FALSE 0.70
non-small cell lung cancer RAS_12 ARID2 Any mutation 57 11 Signature 18 0.01 -0.80 0.94 1005.78 1.01 88 51 5 6 FALSE 0.01
non-small cell lung cancer RAS_12 ARID2 Any mutation 79 18 Signature 2 -0.18 -0.93 0.64 1598.60 1.00 233 74 13 5 FALSE 0.19
non-small cell lung cancer RAS_12 ARID2 Any mutation 50 16 Signature 3 -0.52 -1.44 0.30 1522.98 1.00 178 49 15 1 FALSE 0.60
non-small cell lung cancer RAS_12 ARID2 Any mutation 231 67 Signature 4 -0.42 -0.97 0.07 1595.96 1.00 428 216 52 15 FALSE 0.94
colorectal cancer RAS_12 ARID2 Any mutation 461 104 Signature overall -0.53 -1.60 0.50 1399.33 1.00 1048 438 81 23 FALSE 0.48
non-small cell lung cancer RAS_12 ARID2 Any mutation 417 112 Signature overall -0.27 -0.98 0.40 1556.53 1.00 927 390 85 27 FALSE 0.36
colorectal cancer RAS_12 MTOR Any mutation 8 12 Signature 10 -1.36 -3.39 0.00 1308.53 1.00 19 8 12 0 TRUE 0.93
colorectal cancer RAS_12 MTOR Any mutation 101 17 Signature 15 -0.55 -1.50 0.42 1550.53 1.00 273 97 13 4 TRUE 0.57
colorectal cancer RAS_12 MTOR Any mutation 282 48 Signature 1A -0.46 -1.12 0.17 1486.91 1.00 534 269 35 13 TRUE 0.82
colorectal cancer RAS_12 MTOR Any mutation 72 45 Signature 6 -0.92 -1.79 -0.14 1519.97 1.00 208 67 40 5 TRUE 1.51
non-small cell lung cancer RAS_12 MTOR Any mutation 230 41 Signature 4 0.18 -0.50 0.84 1322.15 1.00 446 215 26 15 TRUE 0.23
colorectal cancer RAS_12 MTOR Any mutation 463 122 Signature overall -0.82 -1.84 0.16 1388.32 1.00 1034 441 100 22 TRUE 0.97
non-small cell lung cancer RAS_12 MTOR Any mutation 230 41 Signature overall 0.12 -4.02 4.44 1451.38 1.00 446 215 26 15 TRUE 0.02
colorectal cancer RAS_12 NOTCH1 Any mutation 8 11 Signature 10 -1.42 -3.40 0.01 1485.60 1.00 20 8 11 0 TRUE 0.99
colorectal cancer RAS_12 NOTCH1 Any mutation 103 17 Signature 15 -0.48 -1.54 0.48 1531.78 1.00 275 99 13 4 TRUE 0.45
colorectal cancer RAS_12 NOTCH1 Any mutation 281 47 Signature 1A -0.37 -1.01 0.24 1557.43 1.00 537 268 34 13 TRUE 0.61
colorectal cancer RAS_12 NOTCH1 Any mutation 76 82 Signature 6 -0.68 -1.32 -0.03 1437.82 1.00 188 64 70 12 TRUE 1.40
non-small cell lung cancer RAS_12 NOTCH1 Any mutation 79 12 Signature 2 -0.97 -2.28 0.27 1484.70 1.00 235 77 10 2 TRUE 0.91
non-small cell lung cancer RAS_12 NOTCH1 Any mutation 230 54 Signature 4 -1.22 -2.05 -0.50 1331.28 1.00 428 223 47 7 TRUE 2.58
colorectal cancer RAS_12 NOTCH1 Any mutation 468 157 Signature overall -0.74 -1.89 0.28 1518.96 1.00 1020 439 128 29 TRUE 0.77
non-small cell lung cancer RAS_12 NOTCH1 Any mutation 309 66 Signature overall -1.12 -2.63 0.25 1093.27 1.00 663 300 57 9 TRUE 0.91
colorectal cancer RAS_12 SETD2 Any mutation 9 22 Signature 10 -1.43 -2.90 -0.14 1563.90 1.00 17 7 20 2 FALSE 1.30
colorectal cancer RAS_12 SETD2 Any mutation 101 13 Signature 15 -1.64 -3.33 -0.25 1320.38 1.00 274 100 12 1 FALSE 1.46
colorectal cancer RAS_12 SETD2 Any mutation 279 31 Signature 1A -1.41 -2.47 -0.50 1371.22 1.00 541 275 27 4 FALSE 2.23
colorectal cancer RAS_12 SETD2 Any mutation 73 39 Signature 6 -1.51 -2.69 -0.45 1365.07 1.00 208 70 36 3 FALSE 2.06
non-small cell lung cancer RAS_12 SETD2 Any mutation 14 16 Signature 13 0.13 -1.01 1.19 1448.81 1.00 74 11 13 3 FALSE 0.09
non-small cell lung cancer RAS_12 SETD2 Any mutation 81 44 Signature 2 0.05 -0.61 0.71 1446.68 1.00 223 70 33 11 FALSE 0.05
non-small cell lung cancer RAS_12 SETD2 Any mutation 51 15 Signature 3 -0.14 -1.22 0.87 1231.63 1.00 182 48 12 3 FALSE 0.10
non-small cell lung cancer RAS_12 SETD2 Any mutation 232 55 Signature 4 -0.26 -0.91 0.32 1335.81 1.00 435 217 40 15 FALSE 0.41
non-small cell lung cancer RAS_12 SETD2 Any mutation 146 14 Signature R2 -0.08 -0.98 0.84 1558.90 1.00 50 136 4 10 FALSE 0.06
colorectal cancer RAS_12 SETD2 Any mutation 462 105 Signature overall -1.49 -2.79 -0.26 1531.49 1.00 1040 452 95 10 FALSE 1.64
non-small cell lung cancer RAS_12 SETD2 Any mutation 524 144 Signature overall -0.06 -0.91 0.78 1551.72 1.00 964 482 102 42 FALSE 0.05
non-small cell lung cancer RAS_12 PBRM1 Any mutation 79 20 Signature 2 -0.21 -1.22 0.73 1394.74 1.00 235 74 15 5 TRUE 0.18
non-small cell lung cancer RAS_12 PBRM1 Any mutation 230 27 Signature 4 -0.47 -1.37 0.29 1482.18 1.00 452 224 21 6 TRUE 0.60
non-small cell lung cancer RAS_12 PBRM1 Any mutation 309 47 Signature overall -0.32 -1.50 0.88 1467.31 1.00 687 298 36 11 TRUE 0.23
colorectal cancer RAS_12 EPHA3 Any mutation 8 14 Signature 10 -0.97 -2.65 0.40 1384.01 1.00 21 7 13 1 FALSE 0.70
colorectal cancer RAS_12 EPHA3 Any mutation 101 13 Signature 15 -0.81 -2.12 0.26 1388.48 1.00 273 99 11 2 FALSE 0.76
colorectal cancer RAS_12 EPHA3 Any mutation 280 42 Signature 1A -0.26 -0.93 0.37 1542.40 1.00 538 267 29 13 FALSE 0.37
colorectal cancer RAS_12 EPHA3 Any mutation 72 26 Signature 6 -0.87 -1.96 0.07 1835.44 1.00 218 69 23 3 FALSE 1.03
non-small cell lung cancer RAS_12 EPHA3 Any mutation 57 13 Signature 18 -0.25 -1.21 0.67 1506.80 1.00 85 53 9 4 FALSE 0.22
non-small cell lung cancer RAS_12 EPHA3 Any mutation 81 27 Signature 2 0.13 -0.64 0.92 1506.48 1.00 227 73 19 8 FALSE 0.13
non-small cell lung cancer RAS_12 EPHA3 Any mutation 51 18 Signature 3 0.52 -0.35 1.42 1537.55 1.00 183 44 11 7 FALSE 0.60
non-small cell lung cancer RAS_12 EPHA3 Any mutation 233 112 Signature 4 -0.35 -0.77 0.07 1530.06 1.00 397 204 83 29 FALSE 0.95
non-small cell lung cancer RAS_12 EPHA3 Any mutation 145 13 Signature R2 -0.34 -1.21 0.56 1507.01 1.00 49 137 5 8 FALSE 0.35
colorectal cancer RAS_12 EPHA3 Any mutation 461 95 Signature overall -0.73 -1.86 0.37 1438.06 1.00 1050 442 76 19 FALSE 0.71
non-small cell lung cancer RAS_12 EPHA3 Any mutation 567 183 Signature overall -0.05 -0.80 0.78 1514.26 1.00 941 511 127 56 FALSE 0.05
non-small cell lung cancer RAS_12 KDR Any mutation 79 12 Signature 2 0.56 -0.49 1.67 1610.18 1.00 238 74 7 5 TRUE 0.50
non-small cell lung cancer RAS_12 KDR Any mutation 51 11 Signature 3 1.05 -0.18 2.22 1522.75 1.00 188 45 5 6 TRUE 1.09
non-small cell lung cancer RAS_12 KDR Any mutation 231 76 Signature 4 -0.81 -1.43 -0.20 1431.93 1.00 414 218 63 13 TRUE 1.97
non-small cell lung cancer RAS_12 KDR Any mutation 361 99 Signature overall 0.28 -0.99 1.82 1505.68 1.00 840 337 75 24 TRUE 0.16
colorectal cancer RAS_12 PTCH1 Any mutation 8 11 Signature 10 -1.14 -2.64 0.28 1433.08 1.00 20 7 10 1 TRUE 0.95
colorectal cancer RAS_12 PTCH1 Any mutation 101 14 Signature 15 -1.10 -2.27 0.00 1354.75 1.00 275 99 12 2 TRUE 1.21
colorectal cancer RAS_12 PTCH1 Any mutation 279 55 Signature 1A -0.94 -1.60 -0.26 1404.14 1.00 530 269 45 10 TRUE 2.28
colorectal cancer RAS_12 PTCH1 Any mutation 73 53 Signature 6 -1.34 -2.29 -0.54 1505.95 1.00 207 69 49 4 TRUE 2.50
colorectal cancer RAS_12 PTCH1 Any mutation 461 133 Signature overall -1.14 -2.17 -0.11 1621.90 1.00 1032 444 116 17 TRUE 1.60
colorectal cancer RAS_12 TET1 Any mutation 8 27 Signature 10 -2.08 -4.10 -0.54 1685.97 1.00 16 7 26 1 FALSE 1.67
colorectal cancer RAS_12 TET1 Any mutation 97 18 Signature 15 -2.66 -5.47 -0.81 1520.84 1.00 266 97 18 0 FALSE 1.57
colorectal cancer RAS_12 TET1 Any mutation 270 25 Signature 1A -0.66 -1.69 0.20 1450.62 1.00 534 264 19 6 FALSE 0.73
colorectal cancer RAS_12 TET1 Any mutation 69 28 Signature 6 -0.57 -1.62 0.39 1459.49 1.00 214 64 23 5 FALSE 0.54
non-small cell lung cancer RAS_12 TET1 Any mutation 79 12 Signature 2 1.07 -0.15 2.37 1469.57 1.00 238 72 5 7 FALSE 1.06
non-small cell lung cancer RAS_12 TET1 Any mutation 232 60 Signature 4 -0.41 -1.02 0.17 1528.08 1.00 432 218 46 14 FALSE 0.73
colorectal cancer RAS_12 TET1 Any mutation 444 98 Signature overall -1.45 -3.19 0.07 1440.82 1.00 1030 432 86 12 FALSE 1.05
non-small cell lung cancer RAS_12 TET1 Any mutation 311 72 Signature overall 0.33 -1.64 2.49 1500.97 1.00 670 290 51 21 FALSE 0.13
uterine cancer RAS_12 FGFR2 Any mutation 36 26 Signature 1A -2.59 -5.13 -0.69 1059.05 1.00 161 35 25 1 TRUE 1.61
uterine cancer RAS_12 FGFR2 Any mutation 13 22 Signature 6 -3.00 -6.56 -0.75 1294.83 1.00 66 13 22 0 TRUE 1.39
uterine cancer RAS_12 FGFR2 Any mutation 49 48 Signature overall -2.74 -5.51 -0.53 1249.35 1.00 227 48 47 1 TRUE 1.46
non-small cell lung cancer RAS_12 TBX3 Any mutation 230 75 Signature 4 -1.01 -1.64 -0.43 1590.49 1.00 417 218 63 12 FALSE 2.96
non-small cell lung cancer RAS_12 TBX3 Any mutation 144 15 Signature R2 -0.41 -1.40 0.64 1610.27 1.00 50 134 5 10 FALSE 0.36
non-small cell lung cancer RAS_12 TBX3 Any mutation 374 90 Signature overall -0.74 -2.49 1.20 1560.85 1.00 467 352 68 22 FALSE 0.39
colorectal cancer RAS_12 SMAD3 Any mutation 104 21 Signature 15 0.30 -0.33 0.91 1352.46 1.00 271 97 14 7 TRUE 0.48
colorectal cancer RAS_12 SMAD3 Any mutation 283 38 Signature 1A 0.26 -0.24 0.78 1514.90 1.00 544 268 23 15 TRUE 0.49
colorectal cancer RAS_12 SMAD3 Any mutation 73 20 Signature 6 0.32 -0.35 0.95 1527.33 1.00 225 67 14 6 TRUE 0.47
colorectal cancer RAS_12 SMAD3 Any mutation 460 79 Signature overall 0.29 -0.30 0.88 1369.85 1.00 1040 432 51 28 TRUE 0.48
non-small cell lung cancer RAS_12 NTRK3 Any mutation 80 15 Signature 2 0.81 -0.19 1.80 1642.67 1.00 238 73 8 7 FALSE 0.95
non-small cell lung cancer RAS_12 NTRK3 Any mutation 50 14 Signature 3 0.67 -0.38 1.68 1445.04 1.00 185 45 9 5 FALSE 0.69
non-small cell lung cancer RAS_12 NTRK3 Any mutation 234 105 Signature 4 -0.35 -0.83 0.10 1598.93 1.00 410 208 79 26 FALSE 0.87
non-small cell lung cancer RAS_12 NTRK3 Any mutation 145 18 Signature R2 0.92 -0.11 2.13 1316.92 1.00 52 129 2 16 FALSE 0.98
non-small cell lung cancer RAS_12 NTRK3 Any mutation 509 152 Signature overall 0.51 -0.53 1.71 1603.12 1.00 885 455 98 54 FALSE 0.44
colorectal cancer RAS_12 GRIN2A Any mutation 8 18 Signature 10 -1.28 -3.01 0.14 1554.59 1.00 17 7 17 1 FALSE 0.97
colorectal cancer RAS_12 GRIN2A Any mutation 101 12 Signature 15 -0.48 -1.74 0.70 1428.79 1.00 278 98 9 3 FALSE 0.36
colorectal cancer RAS_12 GRIN2A Any mutation 280 43 Signature 1A -0.60 -1.37 0.07 1581.11 1.00 533 270 33 10 FALSE 1.00
colorectal cancer RAS_12 GRIN2A Any mutation 72 43 Signature 6 -0.74 -1.64 0.07 1468.22 1.00 205 66 37 6 FALSE 1.06
non-small cell lung cancer RAS_12 GRIN2A Any mutation 79 15 Signature 2 -0.52 -1.70 0.59 1504.37 1.00 233 76 12 3 FALSE 0.42
non-small cell lung cancer RAS_12 GRIN2A Any mutation 232 76 Signature 4 -0.68 -1.27 -0.14 1467.04 1.00 418 216 60 16 FALSE 1.69
non-small cell lung cancer RAS_12 GRIN2A Any mutation 144 13 Signature R2 -0.77 -1.77 0.25 1507.09 1.00 48 137 6 7 FALSE 0.88
colorectal cancer RAS_12 GRIN2A Any mutation 461 116 Signature overall -0.77 -1.95 0.41 1573.16 1.00 1033 441 96 20 FALSE 0.72
non-small cell lung cancer RAS_12 GRIN2A Any mutation 455 104 Signature overall -0.65 -1.88 0.62 1573.93 1.00 699 429 78 26 FALSE 0.52
uterine cancer RAS_12 CTCF Any mutation 19 18 Signature 15 0.32 -0.71 1.27 1523.98 1.00 78 14 13 5 FALSE 0.27
uterine cancer RAS_12 CTCF Any mutation 37 49 Signature 1A 0.31 -0.38 1.05 1421.86 1.00 148 26 38 11 FALSE 0.39
uterine cancer RAS_12 CTCF Any mutation 13 40 Signature 6 -0.43 -1.58 0.60 1493.39 1.00 51 10 37 3 FALSE 0.36
uterine cancer RAS_12 CTCF Any mutation 70 123 Signature overall -0.04 -1.08 0.95 1507.41 1.00 301 51 104 19 FALSE 0.03
non-small cell lung cancer RAS_12 STK11 Any mutation 22 11 Signature 11 1.56 0.63 2.60 1485.63 1.00 21 12 1 10 TRUE 2.81
non-small cell lung cancer RAS_12 STK11 Any mutation 20 19 Signature 15 0.79 -0.06 1.63 1411.38 1.00 102 15 14 5 TRUE 1.15
non-small cell lung cancer RAS_12 STK11 Any mutation 8 11 Signature 16 0.64 -0.33 1.62 1301.70 1.00 43 6 9 2 TRUE 0.68
non-small cell lung cancer RAS_12 STK11 Any mutation 58 38 Signature 18 0.49 -0.15 1.15 1527.21 1.00 72 42 22 16 TRUE 0.87
non-small cell lung cancer RAS_12 STK11 Any mutation 15 17 Signature 19 0.88 -0.02 1.81 1442.07 1.00 37 9 11 6 TRUE 1.28
non-small cell lung cancer RAS_12 STK11 Any mutation 44 21 Signature 1A 1.54 0.78 2.30 1621.20 1.00 213 32 9 12 TRUE 4.08
non-small cell lung cancer RAS_12 STK11 Any mutation 80 55 Signature 2 0.26 -0.35 0.84 1530.11 1.00 212 66 41 14 TRUE 0.40
non-small cell lung cancer RAS_12 STK11 Any mutation 13 13 Signature 20 1.26 0.33 2.19 1673.11 1.00 57 7 7 6 TRUE 2.04
non-small cell lung cancer RAS_12 STK11 Any mutation 50 37 Signature 3 0.77 0.12 1.39 1588.07 1.00 168 38 25 12 TRUE 1.66
non-small cell lung cancer RAS_12 STK11 Any mutation 231 163 Signature 4 0.37 0.01 0.72 1535.89 1.00 372 169 101 62 TRUE 1.38
non-small cell lung cancer RAS_12 STK11 Any mutation 27 13 Signature 8 0.98 0.10 1.85 1376.91 1.00 32 19 5 8 TRUE 1.55
non-small cell lung cancer RAS_12 STK11 Any mutation 145 61 Signature R2 0.75 0.15 1.36 1466.87 1.00 41 97 13 48 TRUE 1.85
non-small cell lung cancer RAS_12 STK11 Any mutation 17 13 Signature U1 1.25 0.34 2.15 1643.00 1.00 87 11 7 6 TRUE 2.13
non-small cell lung cancer RAS_12 STK11 Any mutation 730 472 Signature overall 0.88 0.41 1.32 1560.80 1.00 1457 523 265 207 TRUE 3.78
colorectal cancer RAS_12 ASXL1 Any mutation 8 11 Signature 10 -1.90 -4.74 -0.14 1373.65 1.00 17 8 11 0 TRUE 0.97
colorectal cancer RAS_12 ASXL1 Any mutation 101 14 Signature 15 -2.09 -4.77 -0.44 1485.49 1.00 272 101 14 0 TRUE 1.19
colorectal cancer RAS_12 ASXL1 Any mutation 279 31 Signature 1A -0.55 -1.42 0.19 1493.88 1.00 545 271 23 8 TRUE 0.76
colorectal cancer RAS_12 ASXL1 Any mutation 74 34 Signature 6 -0.21 -1.07 0.57 1298.57 1.00 216 66 26 8 TRUE 0.21
colorectal cancer RAS_12 ASXL1 Any mutation 462 90 Signature overall -1.16 -2.80 0.16 1564.01 1.00 1050 446 74 16 TRUE 0.89
colorectal cancer RAS_12 EP300 Any mutation 101 18 Signature 15 -0.96 -2.03 0.03 1508.30 1.00 272 99 16 2 TRUE 1.14
colorectal cancer RAS_12 EP300 Any mutation 279 36 Signature 1A -0.58 -1.37 0.14 1442.47 1.00 541 270 27 9 TRUE 0.92
colorectal cancer RAS_12 EP300 Any mutation 74 51 Signature 6 -0.70 -1.45 0.02 1371.31 1.00 208 67 44 7 TRUE 1.22
non-small cell lung cancer RAS_12 EP300 Any mutation 13 11 Signature 13 -0.14 -1.48 1.20 1608.44 1.00 78 11 9 2 TRUE 0.07
non-small cell lung cancer RAS_12 EP300 Any mutation 79 20 Signature 2 -1.01 -2.45 0.09 1582.93 1.00 232 78 19 1 TRUE 0.90
non-small cell lung cancer RAS_12 EP300 Any mutation 231 30 Signature 4 -0.02 -0.80 0.74 1662.19 1.00 453 220 19 11 TRUE 0.02
uterine cancer RAS_12 EP300 Any mutation 37 21 Signature 1A -0.24 -1.56 0.89 1500.93 1.00 165 34 18 3 TRUE 0.16
uterine cancer RAS_12 EP300 Any mutation 13 20 Signature 6 0.07 -1.32 1.36 1449.56 1.00 70 10 17 3 TRUE 0.04
colorectal cancer RAS_12 EP300 Any mutation 454 105 Signature overall -0.73 -1.70 0.25 1397.46 1.00 1021 436 87 18 TRUE 0.85
non-small cell lung cancer RAS_12 EP300 Any mutation 323 61 Signature overall -0.35 -1.55 0.84 1391.15 1.00 763 309 47 14 TRUE 0.25
uterine cancer RAS_12 EP300 Any mutation 52 74 Signature overall 0.06 -1.71 1.96 1536.90 1.00 256 44 66 8 TRUE 0.02
colorectal cancer RAS_12 ERBB4 Any mutation 8 18 Signature 10 -0.97 -2.67 0.34 1398.65 1.00 18 7 17 1 TRUE 0.70
colorectal cancer RAS_12 ERBB4 Any mutation 102 23 Signature 15 -0.38 -1.34 0.50 1445.00 1.00 268 97 18 5 TRUE 0.39
colorectal cancer RAS_12 ERBB4 Any mutation 280 43 Signature 1A -0.13 -0.79 0.50 1351.64 1.00 539 266 29 14 TRUE 0.16
colorectal cancer RAS_12 ERBB4 Any mutation 72 31 Signature 6 -0.16 -1.07 0.67 1614.25 1.00 219 65 24 7 TRUE 0.15
non-small cell lung cancer RAS_12 ERBB4 Any mutation 44 11 Signature 1A -0.03 -1.20 1.22 1631.65 1.00 214 41 8 3 TRUE 0.01
non-small cell lung cancer RAS_12 ERBB4 Any mutation 79 17 Signature 2 -0.71 -1.91 0.36 1589.93 1.00 233 77 15 2 TRUE 0.65
non-small cell lung cancer RAS_12 ERBB4 Any mutation 233 97 Signature 4 -0.52 -1.04 -0.03 1558.28 1.00 413 211 75 22 TRUE 1.38
colorectal cancer RAS_12 ERBB4 Any mutation 462 115 Signature overall -0.41 -1.50 0.56 1639.72 1.00 1044 435 88 27 TRUE 0.35
non-small cell lung cancer RAS_12 ERBB4 Any mutation 356 125 Signature overall -0.42 -1.50 0.72 1568.43 1.00 860 329 98 27 TRUE 0.34
colorectal cancer RAS_12 MED12 Any mutation 101 11 Signature 15 -0.65 -1.92 0.50 1460.50 1.00 276 99 9 2 TRUE 0.52
colorectal cancer RAS_12 MED12 Any mutation 280 34 Signature 1A 0.02 -0.68 0.72 1632.65 1.00 547 267 21 13 TRUE 0.02
colorectal cancer RAS_12 MED12 Any mutation 73 42 Signature 6 -1.18 -2.27 -0.22 1552.25 1.00 210 70 39 3 TRUE 1.60
non-small cell lung cancer RAS_12 MED12 Any mutation 79 25 Signature 2 -0.41 -1.25 0.53 1367.19 1.00 227 73 19 6 TRUE 0.43
non-small cell lung cancer RAS_12 MED12 Any mutation 231 72 Signature 4 -0.84 -1.46 -0.27 1330.26 1.00 421 219 60 12 TRUE 2.17
uterine cancer RAS_12 MED12 Any mutation 19 13 Signature 15 -0.75 -2.47 0.64 1549.96 1.00 78 17 11 2 TRUE 0.44
uterine cancer RAS_12 MED12 Any mutation 36 18 Signature 1A -1.51 -3.68 0.02 1415.91 1.00 167 35 17 1 TRUE 1.00
uterine cancer RAS_12 MED12 Any mutation 13 14 Signature 6 -1.24 -3.44 0.46 1621.29 1.00 75 12 13 1 TRUE 0.70
colorectal cancer RAS_12 MED12 Any mutation 454 87 Signature overall -0.59 -1.92 0.72 1460.93 1.00 1033 436 69 18 TRUE 0.44
non-small cell lung cancer RAS_12 MED12 Any mutation 310 97 Signature overall -0.62 -1.61 0.61 1278.02 1.00 648 292 79 18 TRUE 0.56
uterine cancer RAS_12 MED12 Any mutation 69 87 Signature overall -1.36 -3.29 0.30 1515.95 1.00 337 65 83 4 TRUE 0.88
non-small cell lung cancer RAS_12 RBM10 Any mutation 13 11 Signature 13 0.65 -0.33 1.67 1456.54 1.00 78 10 8 3 FALSE 0.72
non-small cell lung cancer RAS_12 RBM10 Any mutation 21 11 Signature 15 0.59 -0.44 1.54 1501.72 1.00 109 18 8 3 FALSE 0.62
non-small cell lung cancer RAS_12 RBM10 Any mutation 58 17 Signature 18 0.61 -0.17 1.35 1655.02 1.00 85 49 8 9 FALSE 0.93
non-small cell lung cancer RAS_12 RBM10 Any mutation 44 21 Signature 1A 0.28 -0.57 1.07 1429.17 1.00 205 40 17 4 FALSE 0.29
non-small cell lung cancer RAS_12 RBM10 Any mutation 79 32 Signature 2 0.83 0.15 1.50 1207.77 1.00 227 65 18 14 FALSE 1.84
non-small cell lung cancer RAS_12 RBM10 Any mutation 52 30 Signature 3 0.52 -0.21 1.21 1495.64 1.00 173 43 21 9 FALSE 0.84
non-small cell lung cancer RAS_12 RBM10 Any mutation 234 128 Signature 4 0.53 0.15 0.90 1488.64 1.00 405 180 74 54 FALSE 2.20
non-small cell lung cancer RAS_12 RBM10 Any mutation 144 20 Signature R2 0.34 -0.41 1.08 1548.22 1.00 49 129 5 15 FALSE 0.42
non-small cell lung cancer RAS_12 RBM10 Any mutation 17 15 Signature U1 0.43 -0.51 1.28 1459.14 1.00 83 14 12 3 FALSE 0.44
non-small cell lung cancer RAS_12 RBM10 Any mutation 662 285 Signature overall 0.53 0.01 1.09 1578.16 1.00 1414 548 171 114 FALSE 1.28
colorectal cancer RAS_12 NF1 Any mutation 8 24 Signature 10 -1.80 -3.56 -0.33 1372.99 1.00 17 7 23 1 TRUE 1.60
colorectal cancer RAS_12 NF1 Any mutation 101 21 Signature 15 -1.41 -2.81 -0.26 1486.90 1.00 269 99 19 2 TRUE 1.49
colorectal cancer RAS_12 NF1 Any mutation 281 40 Signature 1A -0.34 -1.07 0.35 1445.72 1.00 541 269 28 12 TRUE 0.45
colorectal cancer RAS_12 NF1 Any mutation 72 44 Signature 6 -1.84 -3.22 -0.77 1286.78 1.00 208 70 42 2 TRUE 2.54
non-small cell lung cancer RAS_12 NF1 Any mutation 57 13 Signature 18 -0.16 -1.14 0.76 1353.38 1.00 87 51 7 6 TRUE 0.13
non-small cell lung cancer RAS_12 NF1 Any mutation 44 13 Signature 1A -0.64 -1.79 0.39 1459.41 1.00 211 42 11 2 TRUE 0.58
non-small cell lung cancer RAS_12 NF1 Any mutation 81 39 Signature 2 -0.58 -1.42 0.19 1662.28 1.00 216 74 32 7 TRUE 0.84
non-small cell lung cancer RAS_12 NF1 Any mutation 13 13 Signature 20 -0.90 -2.14 0.26 1519.66 1.00 53 12 12 1 TRUE 0.83
non-small cell lung cancer RAS_12 NF1 Any mutation 50 15 Signature 3 -1.07 -2.21 0.03 1433.50 1.00 180 49 14 1 TRUE 1.18
non-small cell lung cancer RAS_12 NF1 Any mutation 231 113 Signature 4 -0.89 -1.38 -0.40 1537.58 1.00 403 211 93 20 TRUE 3.56
non-small cell lung cancer RAS_12 NF1 Any mutation 21 11 Signature 7 -1.23 -2.64 0.03 1528.32 1.00 76 21 11 0 TRUE 1.18
non-small cell lung cancer RAS_12 NF1 Any mutation 145 12 Signature R2 -0.90 -1.78 -0.03 1412.85 1.00 48 139 6 6 TRUE 1.36
uterine cancer RAS_12 NF1 Any mutation 36 21 Signature 1A -0.33 -1.75 0.86 1537.04 1.00 170 33 18 3 TRUE 0.21
uterine cancer RAS_12 NF1 Any mutation 13 24 Signature 6 -0.68 -2.31 0.72 1660.83 1.00 67 11 22 2 TRUE 0.43
colorectal cancer RAS_12 NF1 Any mutation 462 129 Signature overall -1.35 -2.64 -0.10 1409.42 1.00 1035 445 112 17 TRUE 1.41
non-small cell lung cancer RAS_12 NF1 Any mutation 642 229 Signature overall -0.80 -1.47 -0.13 1621.46 1.00 1274 599 186 43 TRUE 1.71
uterine cancer RAS_12 NF1 Any mutation 50 92 Signature overall -0.42 -2.37 1.88 1532.10 1.00 255 44 86 6 TRUE 0.15
non-small cell lung cancer RAS_12 FLT1 Any mutation 58 13 Signature 18 0.42 -0.42 1.42 1436.81 1.00 87 51 6 7 FALSE 0.46
non-small cell lung cancer RAS_12 FLT1 Any mutation 79 12 Signature 2 0.34 -0.51 1.26 1310.60 1.00 238 74 7 5 FALSE 0.34
non-small cell lung cancer RAS_12 FLT1 Any mutation 233 64 Signature 4 -0.09 -0.61 0.43 1307.78 1.00 433 215 46 18 FALSE 0.12
non-small cell lung cancer RAS_12 FLT1 Any mutation 370 89 Signature overall 0.22 -0.65 1.13 1416.28 1.00 758 340 59 30 FALSE 0.22
uterine cancer RAS_12 RASA1 Any mutation 36 20 Signature 1A -2.44 -5.64 -0.26 1597.18 1.00 169 35 19 1 FALSE 1.16
uterine cancer RAS_12 RASA1 Any mutation 13 12 Signature 6 -3.78 -9.13 -0.41 1432.76 1.00 74 13 12 0 FALSE 1.07
uterine cancer RAS_12 RASA1 Any mutation 50 78 Signature overall -3.16 -6.80 -0.20 1481.06 1.00 260 49 77 1 FALSE 1.22
colorectal cancer RAS_12 EPHA5 Any mutation 8 26 Signature 10 -2.66 -5.43 -0.77 1537.80 1.00 15 8 26 0 FALSE 1.67
colorectal cancer RAS_12 EPHA5 Any mutation 101 18 Signature 15 -0.87 -2.19 0.32 1326.20 1.00 273 98 15 3 FALSE 0.77
colorectal cancer RAS_12 EPHA5 Any mutation 280 49 Signature 1A 0.05 -0.58 0.65 1618.08 1.00 536 262 31 18 FALSE 0.06
colorectal cancer RAS_12 EPHA5 Any mutation 72 36 Signature 6 -1.37 -2.57 -0.30 1634.01 1.00 211 69 33 3 FALSE 1.75
non-small cell lung cancer RAS_12 EPHA5 Any mutation 58 24 Signature 18 0.04 -0.78 0.78 1347.24 1.00 79 49 15 9 FALSE 0.04
non-small cell lung cancer RAS_12 EPHA5 Any mutation 79 30 Signature 2 0.21 -0.56 0.96 1255.55 1.00 227 70 21 9 FALSE 0.23
non-small cell lung cancer RAS_12 EPHA5 Any mutation 50 19 Signature 3 0.53 -0.39 1.42 1575.52 1.00 184 43 12 7 FALSE 0.61
non-small cell lung cancer RAS_12 EPHA5 Any mutation 233 109 Signature 4 0.00 -0.43 0.43 1454.16 1.00 410 198 74 35 FALSE 0.01
non-small cell lung cancer RAS_12 EPHA5 Any mutation 144 12 Signature R2 -0.37 -1.31 0.49 1321.77 1.00 50 137 5 7 FALSE 0.39
colorectal cancer RAS_12 EPHA5 Any mutation 461 129 Signature overall -1.18 -2.73 0.25 1681.39 1.00 1035 437 105 24 FALSE 0.94
non-small cell lung cancer RAS_12 EPHA5 Any mutation 564 194 Signature overall 0.09 -0.68 0.86 1288.44 1.00 950 497 127 67 FALSE 0.09
colorectal cancer RAS_12 AR Any mutation 101 21 Signature 15 -0.96 -1.91 -0.09 1385.23 1.00 269 99 19 2 TRUE 1.39
colorectal cancer RAS_12 AR Any mutation 279 33 Signature 1A -0.76 -1.53 -0.05 1412.21 1.00 540 272 26 7 TRUE 1.38
colorectal cancer RAS_12 AR Any mutation 72 37 Signature 6 -0.63 -1.43 0.16 1249.88 1.00 213 66 31 6 TRUE 0.95
non-small cell lung cancer RAS_12 AR Any mutation 232 56 Signature 4 -0.26 -0.89 0.36 1286.26 1.00 437 216 40 16 TRUE 0.38
colorectal cancer RAS_12 AR Any mutation 452 91 Signature overall -0.77 -1.59 0.02 1412.23 1.00 1022 437 76 15 TRUE 1.18
non-small cell lung cancer RAS_12 AR Any mutation 232 56 Signature overall -0.19 -4.34 4.22 1425.46 1.00 437 216 40 16 TRUE 0.03
colorectal cancer RAS_12 ROS1 Any mutation 8 30 Signature 10 -2.26 -4.27 -0.63 1407.81 1.00 16 7 29 1 TRUE 1.82
colorectal cancer RAS_12 ROS1 Any mutation 279 28 Signature 1A -1.30 -2.41 -0.35 1388.11 1.00 544 275 24 4 TRUE 1.86
colorectal cancer RAS_12 ROS1 Any mutation 72 26 Signature 6 -1.14 -2.43 0.01 1401.86 1.00 216 69 23 3 TRUE 1.17
non-small cell lung cancer RAS_12 ROS1 Any mutation 79 14 Signature 2 -1.89 -3.44 -0.58 1451.85 1.00 233 78 13 1 TRUE 2.04
non-small cell lung cancer RAS_12 ROS1 Any mutation 230 42 Signature 4 -1.95 -3.14 -0.99 1373.54 1.00 435 227 39 3 TRUE 3.39
colorectal cancer RAS_12 ROS1 Any mutation 359 84 Signature overall -1.55 -3.57 0.26 1315.60 1.00 776 351 76 8 TRUE 0.99
non-small cell lung cancer RAS_12 ROS1 Any mutation 309 56 Signature overall -1.91 -3.46 -0.65 1403.32 1.00 668 305 52 4 TRUE 2.10
colorectal cancer RAS_12 PIK3CG Any mutation 10 22 Signature 10 -0.31 -1.56 0.90 1384.66 1.00 16 6 18 4 FALSE 0.21
colorectal cancer RAS_12 PIK3CG Any mutation 101 17 Signature 15 0.18 -0.80 1.13 1460.16 1.00 275 95 11 6 FALSE 0.14
colorectal cancer RAS_12 PIK3CG Any mutation 279 29 Signature 1A -0.86 -1.81 -0.01 1564.84 1.00 542 274 24 5 FALSE 1.23
colorectal cancer RAS_12 PIK3CG Any mutation 72 29 Signature 6 -0.23 -1.10 0.64 1200.58 1.00 219 66 23 6 FALSE 0.22
non-small cell lung cancer RAS_12 PIK3CG Any mutation 13 13 Signature 13 -0.60 -2.46 0.85 1565.17 1.00 74 12 12 1 FALSE 0.32
non-small cell lung cancer RAS_12 PIK3CG Any mutation 81 18 Signature 2 1.06 0.15 1.94 1388.09 1.00 237 71 8 10 FALSE 1.62
non-small cell lung cancer RAS_12 PIK3CG Any mutation 231 75 Signature 4 -0.31 -0.88 0.21 1423.99 1.00 423 211 55 20 FALSE 0.60
non-small cell lung cancer RAS_12 PIK3CG Any mutation 144 12 Signature R2 -1.06 -2.20 0.06 1363.53 1.00 48 139 7 5 FALSE 1.21
colorectal cancer RAS_12 PIK3CG Any mutation 462 97 Signature overall -0.28 -1.45 1.00 1489.50 1.00 1052 441 76 21 FALSE 0.19
non-small cell lung cancer RAS_12 PIK3CG Any mutation 469 118 Signature overall -0.22 -1.54 1.16 1570.65 1.00 782 433 82 36 FALSE 0.13
non-small cell lung cancer RAS_12 EGFR Any mutation 13 23 Signature 13 -3.24 -4.35 -2.15 1458.66 1.00 65 12 22 1 TRUE 8.29
non-small cell lung cancer RAS_12 EGFR Any mutation 17 12 Signature 14 -3.24 -4.24 -2.19 1364.61 1.00 30 16 11 1 TRUE 8.94
non-small cell lung cancer RAS_12 EGFR Any mutation 20 54 Signature 15 -3.49 -4.56 -2.52 1476.40 1.00 71 20 54 0 TRUE 10.18
non-small cell lung cancer RAS_12 EGFR Any mutation 8 19 Signature 16 -3.45 -4.60 -2.41 1412.09 1.00 34 8 19 0 TRUE 9.06
non-small cell lung cancer RAS_12 EGFR Any mutation 57 29 Signature 18 -3.55 -4.60 -2.60 1449.22 1.00 68 57 29 0 TRUE 11.16
non-small cell lung cancer RAS_12 EGFR Any mutation 14 16 Signature 19 -3.44 -4.54 -2.42 1355.33 1.00 33 14 16 0 TRUE 9.40
non-small cell lung cancer RAS_12 EGFR Any mutation 44 197 Signature 1A -3.81 -4.85 -2.92 1417.69 1.00 97 44 197 0 TRUE 14.16
non-small cell lung cancer RAS_12 EGFR Any mutation 79 79 Signature 2 -3.42 -4.41 -2.50 1403.48 1.00 183 78 78 1 TRUE 11.64
non-small cell lung cancer RAS_12 EGFR Any mutation 13 35 Signature 20 -3.48 -4.54 -2.48 1398.65 1.00 36 13 35 0 TRUE 9.87
non-small cell lung cancer RAS_12 EGFR Any mutation 9 29 Signature 21 -3.47 -4.64 -2.47 1385.19 1.00 31 9 29 0 TRUE 9.93
non-small cell lung cancer RAS_12 EGFR Any mutation 50 89 Signature 3 -3.12 -4.03 -2.25 1448.59 1.00 115 47 86 3 TRUE 10.87
non-small cell lung cancer RAS_12 EGFR Any mutation 230 114 Signature 4 -2.81 -3.62 -2.05 1568.83 1.00 386 223 107 7 TRUE 11.65
non-small cell lung cancer RAS_12 EGFR Any mutation 11 18 Signature 6 -3.46 -4.55 -2.40 1493.32 1.00 29 11 18 0 TRUE 9.20
non-small cell lung cancer RAS_12 EGFR Any mutation 21 34 Signature 7 -3.52 -4.63 -2.46 1482.04 1.00 57 21 34 0 TRUE 9.56
non-small cell lung cancer RAS_12 EGFR Any mutation 26 14 Signature 8 -3.29 -4.33 -2.28 1364.10 1.00 25 25 13 1 TRUE 9.59
non-small cell lung cancer RAS_12 EGFR Any mutation 6 11 Signature R3 -3.43 -4.56 -2.41 1453.57 1.00 15 6 11 0 TRUE 9.39
non-small cell lung cancer RAS_12 EGFR Any mutation 17 46 Signature U1 -3.51 -4.62 -2.56 1468.34 1.00 53 17 46 0 TRUE 10.40
non-small cell lung cancer RAS_12 EGFR Any mutation 641 853 Signature overall -3.40 -4.03 -2.81 1366.82 1.00 1371 627 839 14 TRUE 25.75
colorectal cancer RAS_12 ARID1B Any mutation 101 22 Signature 15 -1.29 -2.39 -0.25 1259.27 1.00 269 98 19 3 TRUE 1.81
colorectal cancer RAS_12 ARID1B Any mutation 280 53 Signature 1A -1.25 -2.02 -0.59 1453.92 1.00 529 272 45 8 TRUE 3.22
colorectal cancer RAS_12 ARID1B Any mutation 72 46 Signature 6 -1.86 -3.26 -0.91 1311.59 1.00 202 71 45 1 TRUE 2.72
non-small cell lung cancer RAS_12 ARID1B Any mutation 79 13 Signature 2 0.15 -0.85 1.29 1241.81 1.00 237 74 8 5 TRUE 0.10
non-small cell lung cancer RAS_12 ARID1B Any mutation 230 42 Signature 4 -0.45 -1.19 0.21 1477.46 1.00 441 221 33 9 TRUE 0.65
uterine cancer RAS_12 ARID1B Any mutation 36 17 Signature 1A -0.09 -1.37 1.06 1524.79 1.00 170 33 14 3 TRUE 0.05
uterine cancer RAS_12 ARID1B Any mutation 13 39 Signature 6 -0.22 -1.36 0.88 1428.26 1.00 58 9 35 4 TRUE 0.15
colorectal cancer RAS_12 ARID1B Any mutation 453 121 Signature overall -1.45 -2.47 -0.49 1101.66 1.00 1000 441 109 12 TRUE 2.47
non-small cell lung cancer RAS_12 ARID1B Any mutation 309 55 Signature overall -0.16 -1.35 1.17 1431.65 1.00 678 295 41 14 TRUE 0.09
uterine cancer RAS_12 ARID1B Any mutation 50 78 Signature overall -0.05 -1.86 2.04 1446.86 1.00 255 42 70 8 TRUE 0.02
non-small cell lung cancer RAS_12 MET Any mutation 79 23 Signature 2 -1.00 -2.20 -0.08 1449.27 1.00 226 78 22 1 TRUE 1.18
non-small cell lung cancer RAS_12 MET Any mutation 50 11 Signature 3 -0.65 -1.68 0.35 1560.80 1.00 185 48 9 2 TRUE 0.67
non-small cell lung cancer RAS_12 MET Any mutation 230 34 Signature 4 -0.56 -1.31 0.11 1465.39 1.00 451 221 25 9 TRUE 0.92
non-small cell lung cancer RAS_12 MET Any mutation 359 68 Signature overall -0.74 -1.67 0.10 1429.56 1.00 862 347 56 12 TRUE 0.92
colorectal cancer RAS_12 BRAF Any mutation 101 48 Signature 15 -2.08 -2.89 -1.31 1497.33 1.00 241 98 45 3 TRUE 6.73
colorectal cancer RAS_12 BRAF Any mutation 280 99 Signature 1A -2.09 -2.79 -1.47 1564.45 1.00 476 273 92 7 TRUE 9.11
colorectal cancer RAS_12 BRAF Any mutation 73 60 Signature 6 -2.15 -3.02 -1.39 1426.95 1.00 186 71 58 2 TRUE 6.44
non-small cell lung cancer RAS_12 BRAF Any mutation 57 11 Signature 18 -1.21 -2.23 -0.39 1408.17 1.00 83 56 10 1 TRUE 2.04
non-small cell lung cancer RAS_12 BRAF Any mutation 79 20 Signature 2 -1.15 -2.00 -0.35 1423.91 1.00 227 77 18 2 TRUE 2.15
non-small cell lung cancer RAS_12 BRAF Any mutation 50 20 Signature 3 -1.21 -2.19 -0.41 1347.37 1.00 174 49 19 1 TRUE 2.06
non-small cell lung cancer RAS_12 BRAF Any mutation 230 50 Signature 4 -0.96 -1.63 -0.32 1456.72 1.00 434 220 40 10 TRUE 2.40
colorectal cancer RAS_12 BRAF Any mutation 454 207 Signature overall -2.11 -2.89 -1.38 1464.60 1.00 903 442 195 12 TRUE 7.30
non-small cell lung cancer RAS_12 BRAF Any mutation 416 101 Signature overall -1.12 -1.89 -0.43 1421.83 1.00 918 402 87 14 TRUE 2.63
colorectal cancer RAS_12 B2M Any mutation 8 14 Signature 10 -1.48 -3.56 -0.11 1378.01 1.00 19 8 14 0 FALSE 1.04
colorectal cancer RAS_12 B2M Any mutation 99 20 Signature 15 -0.64 -1.69 0.28 1474.14 1.00 269 95 16 4 FALSE 0.68
colorectal cancer RAS_12 B2M Any mutation 272 46 Signature 1A -0.80 -1.49 -0.14 1490.26 1.00 530 263 37 9 FALSE 1.64
colorectal cancer RAS_12 B2M Any mutation 73 51 Signature 6 -0.51 -1.30 0.20 1440.25 1.00 206 64 42 9 FALSE 0.75
colorectal cancer RAS_12 B2M Any mutation 452 131 Signature overall -0.85 -1.98 0.13 1469.30 1.00 1024 430 109 22 FALSE 0.99
colorectal cancer RAS_12 CARD11 Any mutation 101 14 Signature 15 -0.45 -1.54 0.44 1523.08 1.00 273 98 11 3 FALSE 0.45
colorectal cancer RAS_12 CARD11 Any mutation 281 58 Signature 1A -0.13 -0.66 0.39 1380.84 1.00 530 262 39 19 FALSE 0.20
colorectal cancer RAS_12 CARD11 Any mutation 72 38 Signature 6 -0.70 -1.67 0.08 1346.11 1.00 213 68 34 4 FALSE 0.95
non-small cell lung cancer RAS_12 CARD11 Any mutation 81 16 Signature 2 0.48 -0.48 1.53 1397.84 1.00 236 74 9 7 FALSE 0.45
non-small cell lung cancer RAS_12 CARD11 Any mutation 230 63 Signature 4 -0.28 -0.88 0.28 1374.00 1.00 429 214 47 16 FALSE 0.47
colorectal cancer RAS_12 CARD11 Any mutation 454 110 Signature overall -0.42 -1.32 0.44 1573.20 1.00 1016 428 84 26 FALSE 0.47
non-small cell lung cancer RAS_12 CARD11 Any mutation 311 79 Signature overall 0.08 -1.43 1.48 1646.35 1.00 665 288 56 23 FALSE 0.04
non-small cell lung cancer RAS_12 INPP4B Any mutation 80 15 Signature 2 0.90 -0.09 1.97 1436.92 1.00 239 72 7 8 FALSE 1.03
non-small cell lung cancer RAS_12 INPP4B Any mutation 231 60 Signature 4 0.06 -0.52 0.60 1483.75 1.00 438 212 41 19 FALSE 0.08
non-small cell lung cancer RAS_12 INPP4B Any mutation 311 75 Signature overall 0.50 -1.00 2.24 1550.15 1.00 677 284 48 27 FALSE 0.28
non-small cell lung cancer RAS_12 NFE2L2 Any mutation 13 15 Signature 13 -0.73 -2.32 0.52 1449.28 1.00 74 12 14 1 FALSE 0.50
non-small cell lung cancer RAS_12 NFE2L2 Any mutation 79 32 Signature 2 -0.60 -1.54 0.25 1383.47 1.00 225 74 27 5 FALSE 0.73
non-small cell lung cancer RAS_12 NFE2L2 Any mutation 231 20 Signature 4 -0.37 -1.33 0.49 1493.04 1.00 458 225 14 6 FALSE 0.38
non-small cell lung cancer RAS_12 NFE2L2 Any mutation 323 67 Signature overall -0.59 -1.90 0.64 1235.27 1.00 757 311 55 12 FALSE 0.46
colorectal cancer RAS_12 SOX9 Any mutation 103 40 Signature 15 -0.04 -0.62 0.52 1541.48 1.00 254 93 30 10 FALSE 0.05
colorectal cancer RAS_12 SOX9 Any mutation 283 105 Signature 1A 0.43 0.02 0.82 1244.39 1.00 513 236 58 47 FALSE 1.45
colorectal cancer RAS_12 SOX9 Any mutation 72 59 Signature 6 -0.17 -0.82 0.40 1510.40 1.00 197 62 49 10 FALSE 0.23
colorectal cancer RAS_12 SOX9 Any mutation 458 204 Signature overall 0.07 -0.60 0.69 1568.33 1.00 964 391 137 67 FALSE 0.08
colorectal cancer RAS_12 SMAD2 Any mutation 101 16 Signature 15 0.38 -0.38 1.04 1439.90 1.00 273 96 11 5 TRUE 0.55
colorectal cancer RAS_12 SMAD2 Any mutation 281 33 Signature 1A 0.56 0.00 1.16 1403.19 1.00 553 264 16 17 TRUE 1.24
colorectal cancer RAS_12 SMAD2 Any mutation 72 17 Signature 6 0.37 -0.40 1.03 1421.47 1.00 228 68 13 4 TRUE 0.52
colorectal cancer RAS_12 SMAD2 Any mutation 454 66 Signature overall 0.44 -0.18 1.06 1394.62 1.00 1054 428 40 26 TRUE 0.76
non-small cell lung cancer RAS_12 GLI1 Any mutation 219 44 Signature 4 0.28 -0.36 0.89 1414.94 1.00 392 201 26 18 FALSE 0.43
non-small cell lung cancer RAS_12 GLI1 Any mutation 219 44 Signature overall 0.26 -3.97 4.35 1501.72 1.00 392 201 26 18 FALSE 0.05
colorectal cancer RAS_12 ZFHX3 Any mutation 9 17 Signature 10 -0.85 -2.10 0.23 1455.73 1.00 14 7 15 2 FALSE 0.82
colorectal cancer RAS_12 ZFHX3 Any mutation 92 31 Signature 15 -0.61 -1.42 0.16 1427.30 1.00 242 86 25 6 FALSE 0.87
colorectal cancer RAS_12 ZFHX3 Any mutation 265 80 Signature 1A -0.76 -1.29 -0.24 1618.26 1.00 480 249 64 16 FALSE 2.38
colorectal cancer RAS_12 ZFHX3 Any mutation 72 81 Signature 6 -0.70 -1.37 -0.10 1517.73 1.00 175 60 69 12 FALSE 1.47
non-small cell lung cancer RAS_12 ZFHX3 Any mutation 75 18 Signature 2 -0.75 -1.90 0.39 1423.36 1.00 200 72 15 3 FALSE 0.69
non-small cell lung cancer RAS_12 ZFHX3 Any mutation 219 61 Signature 4 -0.41 -1.01 0.17 1533.14 1.00 375 202 44 17 FALSE 0.75
non-small cell lung cancer RAS_12 ZFHX3 Any mutation 129 14 Signature R2 -1.11 -2.16 -0.10 1564.59 1.00 40 123 8 6 FALSE 1.46
uterine cancer RAS_12 ZFHX3 Any mutation 19 13 Signature 15 0.77 -0.46 1.93 1329.37 1.00 76 14 8 5 FALSE 0.70
uterine cancer RAS_12 ZFHX3 Any mutation 33 56 Signature 1A -0.68 -1.66 0.17 1253.57 1.00 130 28 51 5 FALSE 0.82
uterine cancer RAS_12 ZFHX3 Any mutation 13 45 Signature 6 0.59 -0.51 1.68 1309.22 1.00 52 5 37 8 FALSE 0.54
colorectal cancer RAS_12 ZFHX3 Any mutation 438 209 Signature overall -0.71 -1.58 0.12 1449.74 1.00 911 402 173 36 FALSE 1.02
non-small cell lung cancer RAS_12 ZFHX3 Any mutation 423 93 Signature overall -0.74 -2.03 0.55 1402.49 1.00 615 397 67 26 FALSE 0.61
uterine cancer RAS_12 ZFHX3 Any mutation 71 184 Signature overall 0.04 -1.07 1.27 1456.81 1.00 284 49 162 22 FALSE 0.03
colorectal cancer RAS_12 MGA Any mutation 8 15 Signature 10 -1.68 -3.73 -0.16 1464.53 1.00 15 8 15 0 FALSE 1.13
colorectal cancer RAS_12 MGA Any mutation 91 16 Signature 15 -0.71 -1.87 0.35 1304.09 1.00 244 88 13 3 FALSE 0.68
colorectal cancer RAS_12 MGA Any mutation 264 42 Signature 1A -0.25 -0.94 0.42 1472.65 1.00 500 251 29 13 FALSE 0.34
colorectal cancer RAS_12 MGA Any mutation 70 36 Signature 6 -0.60 -1.52 0.24 1381.60 1.00 193 64 30 6 FALSE 0.75
non-small cell lung cancer RAS_12 MGA Any mutation 75 28 Signature 2 -0.65 -1.64 0.24 1707.23 1.00 202 71 24 4 FALSE 0.77
non-small cell lung cancer RAS_12 MGA Any mutation 220 79 Signature 4 -0.23 -0.75 0.25 1512.76 1.00 366 196 55 24 FALSE 0.43
non-small cell lung cancer RAS_12 MGA Any mutation 129 13 Signature R2 0.00 -1.06 1.08 1359.15 1.00 45 119 3 10 FALSE 0.00
uterine cancer RAS_12 MGA Any mutation 33 19 Signature 1A -3.45 -9.32 -0.51 1375.31 1.00 152 33 19 0 FALSE 0.89
uterine cancer RAS_12 MGA Any mutation 12 14 Signature 6 -3.22 -9.37 -0.24 1172.00 1.00 66 12 14 0 FALSE 0.76
colorectal cancer RAS_12 MGA Any mutation 433 109 Signature overall -0.76 -2.03 0.30 1394.86 1.00 952 411 87 22 FALSE 0.73
non-small cell lung cancer RAS_12 MGA Any mutation 424 120 Signature overall -0.28 -1.53 0.98 1521.25 1.00 613 386 82 38 FALSE 0.19
uterine cancer RAS_12 MGA Any mutation 50 82 Signature overall -1.66 -5.52 1.48 1348.09 1.00 238 45 77 5 FALSE 0.47
colorectal cancer RAS_12 KMT2B Any mutation 51 18 Signature 15 -1.51 -2.95 -0.32 1453.70 1.00 131 50 17 1 FALSE 1.56
colorectal cancer RAS_12 KMT2B Any mutation 158 64 Signature 1A -0.57 -1.18 0.00 1462.80 1.00 266 142 48 16 FALSE 1.25
colorectal cancer RAS_12 KMT2B Any mutation 49 86 Signature 6 -0.97 -1.65 -0.29 1513.00 1.00 84 37 74 12 FALSE 2.23
colorectal cancer RAS_12 KMT2B Any mutation 258 168 Signature overall -1.01 -2.34 0.11 1306.69 1.00 481 229 139 29 FALSE 1.01
colorectal cancer RAS_12 TCF7L2 Any mutation 93 48 Signature 15 0.27 -0.29 0.84 1111.06 1.00 227 77 32 16 FALSE 0.45
colorectal cancer RAS_12 TCF7L2 Any mutation 268 115 Signature 1A 0.04 -0.35 0.42 1552.42 1.00 458 229 76 39 FALSE 0.08
colorectal cancer RAS_12 TCF7L2 Any mutation 35 12 Signature 2 0.70 -0.07 1.77 1540.30 1.00 35 25 2 10 FALSE 0.86
colorectal cancer RAS_12 TCF7L2 Any mutation 70 69 Signature 6 -0.23 -0.83 0.33 1361.83 1.00 170 58 57 12 FALSE 0.36
colorectal cancer RAS_12 TCF7L2 Any mutation 466 244 Signature overall 0.18 -0.42 0.83 1524.78 1.00 890 389 167 77 FALSE 0.25
colorectal cancer RAS_12 ANKRD11 Any mutation 10 12 Signature 10 -0.68 -2.06 0.58 1605.42 1.00 16 7 9 3 FALSE 0.52
colorectal cancer RAS_12 ANKRD11 Any mutation 87 17 Signature 15 -1.53 -2.92 -0.34 1605.26 1.00 240 86 16 1 FALSE 1.69
colorectal cancer RAS_12 ANKRD11 Any mutation 255 47 Signature 1A -0.92 -1.63 -0.25 1417.46 1.00 481 246 38 9 FALSE 2.01
colorectal cancer RAS_12 ANKRD11 Any mutation 66 57 Signature 6 -1.66 -2.70 -0.77 1336.08 1.00 177 63 54 3 FALSE 3.02
colorectal cancer RAS_12 ANKRD11 Any mutation 418 133 Signature overall -1.19 -2.22 -0.20 1603.18 1.00 914 402 117 16 FALSE 1.61
colorectal cancer RAS_12 POLD1 Any mutation 91 15 Signature 15 -1.77 -3.85 -0.49 1500.57 1.00 247 91 15 0 TRUE 1.31
colorectal cancer RAS_12 POLD1 Any mutation 266 43 Signature 1A -0.39 -1.06 0.27 1410.06 1.00 501 253 30 13 TRUE 0.59
colorectal cancer RAS_12 POLD1 Any mutation 70 44 Signature 6 -1.18 -2.20 -0.29 1387.10 1.00 190 66 40 4 TRUE 1.79
colorectal cancer RAS_12 POLD1 Any mutation 427 102 Signature overall -1.10 -2.42 0.04 1463.31 1.00 938 410 85 17 TRUE 1.11
non-small cell lung cancer RAS_12 PREX2 Any mutation 126 52 Signature 4 -0.18 -0.80 0.43 1584.78 1.00 208 110 36 16 FALSE 0.24
non-small cell lung cancer RAS_12 PREX2 Any mutation 126 52 Signature overall -0.20 -4.34 3.78 1513.51 1.00 208 110 36 16 FALSE 0.04
colorectal cancer RAS_12 AMER1 Any mutation 101 34 Signature 15 0.21 -0.41 0.76 1381.58 1.00 261 91 24 10 FALSE 0.32
colorectal cancer RAS_12 AMER1 Any mutation 279 61 Signature 1A 0.35 -0.10 0.81 1421.12 1.00 538 252 34 27 FALSE 0.89
colorectal cancer RAS_12 AMER1 Any mutation 72 36 Signature 6 0.16 -0.45 0.70 1481.27 1.00 216 64 28 8 FALSE 0.23
non-small cell lung cancer RAS_12 AMER1 Any mutation 79 11 Signature 2 0.61 -0.59 1.81 1546.10 1.00 239 74 6 5 FALSE 0.50
non-small cell lung cancer RAS_12 AMER1 Any mutation 232 83 Signature 4 -0.20 -0.69 0.27 1403.74 1.00 427 209 60 23 FALSE 0.38
colorectal cancer RAS_12 AMER1 Any mutation 452 131 Signature overall 0.24 -0.34 0.79 1430.19 1.00 1015 407 86 45 FALSE 0.38
non-small cell lung cancer RAS_12 AMER1 Any mutation 311 94 Signature overall 0.19 -1.70 2.20 1486.09 1.00 666 283 66 28 FALSE 0.08
non-small cell lung cancer RAS_12 EPHA7 Any mutation 44 13 Signature 3 -0.36 -1.61 0.91 1560.88 1.00 163 41 10 3 FALSE 0.25
non-small cell lung cancer RAS_12 EPHA7 Any mutation 217 51 Signature 4 -0.85 -1.59 -0.21 1461.68 1.00 377 208 42 9 FALSE 1.75
non-small cell lung cancer RAS_12 EPHA7 Any mutation 261 64 Signature overall -0.61 -2.10 0.80 1494.10 1.00 540 249 52 12 FALSE 0.37
colorectal cancer KRAS_12 SPEN Any mutation 8 21 Signature 10 -1.37 -3.08 0.02 1401.47 1.00 18 7 20 1 FALSE 1.10
colorectal cancer KRAS_12 SPEN Any mutation 99 18 Signature 15 -0.76 -2.01 0.31 1455.31 1.00 276 96 15 3 FALSE 0.70
colorectal cancer KRAS_12 SPEN Any mutation 271 38 Signature 1A -0.30 -0.97 0.38 1480.99 1.00 553 260 27 11 FALSE 0.40
colorectal cancer KRAS_12 SPEN Any mutation 70 61 Signature 6 -0.75 -1.53 0.03 1394.65 1.00 204 62 53 8 FALSE 1.24
non-small cell lung cancer KRAS_12 SPEN Any mutation 79 39 Signature 2 -4.10 -9.65 -1.43 1551.72 1.00 233 79 39 0 FALSE 1.16
non-small cell lung cancer KRAS_12 SPEN Any mutation 231 24 Signature 4 0.05 -0.84 0.89 1435.17 1.00 459 222 15 9 FALSE 0.04
uterine cancer KRAS_12 SPEN Any mutation 20 13 Signature 15 0.97 -0.21 2.20 1493.99 1.00 83 15 8 5 FALSE 0.97
uterine cancer KRAS_12 SPEN Any mutation 34 21 Signature 1A -0.35 -1.75 0.78 1623.14 1.00 169 32 19 2 FALSE 0.23
uterine cancer KRAS_12 SPEN Any mutation 14 21 Signature 6 0.81 -0.33 1.91 1383.08 1.00 73 9 16 5 FALSE 0.82
colorectal cancer KRAS_12 SPEN Any mutation 448 138 Signature overall -0.80 -2.07 0.42 1429.28 1.00 1051 425 115 23 FALSE 0.72
non-small cell lung cancer KRAS_12 SPEN Any mutation 310 63 Signature overall -1.70 -5.67 1.59 1336.26 1.00 692 301 54 9 FALSE 0.47
uterine cancer KRAS_12 SPEN Any mutation 71 93 Signature overall 0.54 -0.85 2.07 1673.33 1.00 348 56 78 15 FALSE 0.34
colorectal cancer KRAS_12 KMT2C Any mutation 9 32 Signature 10 -1.43 -2.92 -0.08 1261.33 1.00 15 7 30 2 FALSE 1.38
colorectal cancer KRAS_12 KMT2C Any mutation 95 22 Signature 15 -0.91 -2.12 0.11 1450.78 1.00 270 92 19 3 FALSE 0.98
colorectal cancer KRAS_12 KMT2C Any mutation 265 60 Signature 1A -0.36 -0.99 0.21 1525.61 1.00 527 249 44 16 FALSE 0.62
colorectal cancer KRAS_12 KMT2C Any mutation 65 65 Signature 6 -0.51 -1.26 0.17 1520.21 1.00 195 55 55 10 FALSE 0.78
non-small cell lung cancer KRAS_12 KMT2C Any mutation 13 22 Signature 13 0.12 -0.75 1.12 1250.62 1.00 69 9 18 4 FALSE 0.09
non-small cell lung cancer KRAS_12 KMT2C Any mutation 80 40 Signature 2 0.15 -0.57 0.79 1476.12 1.00 218 68 28 12 FALSE 0.18
non-small cell lung cancer KRAS_12 KMT2C Any mutation 49 13 Signature 3 -0.50 -1.62 0.41 1569.20 1.00 182 48 12 1 FALSE 0.48
non-small cell lung cancer KRAS_12 KMT2C Any mutation 230 76 Signature 4 -0.29 -0.80 0.18 1365.45 1.00 422 210 56 20 FALSE 0.61
uterine cancer KRAS_12 KMT2C Any mutation 18 17 Signature 15 -0.70 -2.34 0.65 1424.99 1.00 77 16 15 2 FALSE 0.44
uterine cancer KRAS_12 KMT2C Any mutation 32 20 Signature 1A -0.77 -2.30 0.52 1570.25 1.00 156 30 18 2 FALSE 0.55
uterine cancer KRAS_12 KMT2C Any mutation 13 23 Signature 6 -1.30 -3.16 0.21 1463.97 1.00 64 12 22 1 FALSE 0.90
colorectal cancer KRAS_12 KMT2C Any mutation 434 179 Signature overall -0.78 -1.96 0.47 1201.75 1.00 1007 403 148 31 FALSE 0.71
non-small cell lung cancer KRAS_12 KMT2C Any mutation 372 151 Signature overall -0.13 -0.91 0.61 1291.09 1.00 891 335 114 37 FALSE 0.14
uterine cancer KRAS_12 KMT2C Any mutation 65 118 Signature overall -0.79 -2.35 0.69 1514.61 1.00 317 58 111 7 FALSE 0.52
cancer of unknown primary KRAS_12 TP53 Any mutation 12 11 Signature 11 0.06 -0.87 1.11 1295.26 1.00 8 5 4 7 TRUE 0.05
cancer of unknown primary KRAS_12 TP53 Any mutation 10 28 Signature 15 -0.13 -0.98 0.86 1533.36 1.00 19 3 21 7 TRUE 0.11
cancer of unknown primary KRAS_12 TP53 Any mutation 32 66 Signature 1A -0.50 -1.17 0.19 1393.24 1.00 37 18 52 14 TRUE 0.80
cancer of unknown primary KRAS_12 TP53 Any mutation 7 31 Signature 2 -0.79 -1.77 0.09 1489.69 1.00 21 5 29 2 TRUE 1.01
cancer of unknown primary KRAS_12 TP53 Any mutation 6 18 Signature 3 -0.50 -1.51 0.45 1679.61 1.00 6 3 15 3 TRUE 0.49
cancer of unknown primary KRAS_12 TP53 Any mutation 20 70 Signature 4 -0.49 -1.25 0.28 1511.25 1.00 12 7 57 13 TRUE 0.66
colorectal cancer KRAS_12 TP53 Any mutation 9 32 Signature 10 -0.94 -1.58 -0.35 1455.30 1.00 6 3 26 6 TRUE 2.59
colorectal cancer KRAS_12 TP53 Any mutation 22 28 Signature 11 -0.59 -1.19 0.00 1450.07 1.00 2 7 13 15 TRUE 1.31
colorectal cancer KRAS_12 TP53 Any mutation 101 311 Signature 15 -1.00 -1.42 -0.61 1397.78 1.00 58 39 249 62 TRUE 6.29
colorectal cancer KRAS_12 TP53 Any mutation 7 36 Signature 17 -1.03 -1.68 -0.42 1436.66 1.00 8 2 31 5 TRUE 2.90
colorectal cancer KRAS_12 TP53 Any mutation 16 36 Signature 18 -1.02 -1.70 -0.43 1289.49 1.00 4 8 28 8 TRUE 2.88
colorectal cancer KRAS_12 TP53 Any mutation 19 31 Signature 19 -1.10 -1.74 -0.56 1474.13 1.00 5 12 24 7 TRUE 3.53
colorectal cancer KRAS_12 TP53 Any mutation 285 655 Signature 1A -0.81 -1.09 -0.52 1533.08 1.00 127 106 476 179 TRUE 8.02
colorectal cancer KRAS_12 TP53 Any mutation 7 15 Signature 1B -0.90 -1.57 -0.28 1250.48 1.00 4 3 11 4 TRUE 2.18
colorectal cancer KRAS_12 TP53 Any mutation 37 56 Signature 2 -1.03 -1.62 -0.54 1426.37 1.00 9 20 39 17 TRUE 3.77
colorectal cancer KRAS_12 TP53 Any mutation 9 23 Signature 20 -0.86 -1.50 -0.23 1668.61 1.00 8 3 17 6 TRUE 2.17
colorectal cancer KRAS_12 TP53 Any mutation 7 20 Signature 21 -0.88 -1.52 -0.26 1573.88 1.00 6 2 15 5 TRUE 2.23
colorectal cancer KRAS_12 TP53 Any mutation 14 35 Signature 3 -0.89 -1.54 -0.31 1476.67 1.00 2 5 26 9 TRUE 2.46
colorectal cancer KRAS_12 TP53 Any mutation 18 36 Signature 4 -0.86 -1.47 -0.29 1472.80 1.00 3 7 25 11 TRUE 2.46
colorectal cancer KRAS_12 TP53 Any mutation 79 236 Signature 6 -0.60 -1.04 -0.14 1445.34 1.00 85 27 184 52 TRUE 2.09
colorectal cancer KRAS_12 TP53 Any mutation 14 28 Signature 7 -0.97 -1.60 -0.36 1377.44 1.00 5 7 21 7 TRUE 2.74
colorectal cancer KRAS_12 TP53 Any mutation 14 13 Signature 8 -0.68 -1.27 -0.02 1462.64 1.00 4 6 5 8 TRUE 1.49
colorectal cancer KRAS_12 TP53 Any mutation 16 16 Signature R2 -0.71 -1.32 -0.08 1532.36 1.00 0 7 7 9 TRUE 1.57
non-small cell lung cancer KRAS_12 TP53 Any mutation 21 12 Signature 11 -1.60 -2.49 -0.74 1385.95 1.00 13 19 10 2 TRUE 3.40
non-small cell lung cancer KRAS_12 TP53 Any mutation 15 79 Signature 13 -0.79 -1.51 -0.09 1425.69 1.00 27 4 68 11 TRUE 1.46
non-small cell lung cancer KRAS_12 TP53 Any mutation 17 36 Signature 14 -1.15 -1.91 -0.40 1579.31 1.00 14 10 29 7 TRUE 2.43
non-small cell lung cancer KRAS_12 TP53 Any mutation 20 87 Signature 15 -1.40 -2.12 -0.69 1706.80 1.00 40 13 80 7 TRUE 3.87
non-small cell lung cancer KRAS_12 TP53 Any mutation 10 39 Signature 16 -0.82 -1.59 0.04 1337.96 1.00 21 3 32 7 TRUE 1.27
non-small cell lung cancer KRAS_12 TP53 Any mutation 58 92 Signature 18 -0.95 -1.49 -0.42 1414.93 1.00 32 32 66 26 TRUE 3.22
non-small cell lung cancer KRAS_12 TP53 Any mutation 14 31 Signature 19 -1.10 -1.93 -0.30 1641.68 1.00 26 9 26 5 TRUE 2.09
non-small cell lung cancer KRAS_12 TP53 Any mutation 46 149 Signature 1A -0.99 -1.52 -0.47 1595.07 1.00 96 28 131 18 TRUE 3.43
non-small cell lung cancer KRAS_12 TP53 Any mutation 81 223 Signature 2 -0.81 -1.26 -0.36 1283.90 1.00 85 39 181 42 TRUE 3.28
non-small cell lung cancer KRAS_12 TP53 Any mutation 13 46 Signature 20 -1.44 -2.28 -0.66 1468.68 1.00 22 9 42 4 TRUE 3.24
non-small cell lung cancer KRAS_12 TP53 Any mutation 9 37 Signature 21 -1.75 -2.65 -0.86 1520.47 1.00 21 8 36 1 TRUE 3.90
non-small cell lung cancer KRAS_12 TP53 Any mutation 52 161 Signature 3 -1.16 -1.70 -0.64 1353.69 1.00 65 30 139 22 TRUE 4.69
non-small cell lung cancer KRAS_12 TP53 Any mutation 233 522 Signature 4 -1.71 -2.03 -1.39 1543.04 1.00 92 134 423 99 TRUE 24.34
non-small cell lung cancer KRAS_12 TP53 Any mutation 11 36 Signature 6 -1.25 -2.08 -0.45 1439.73 1.00 11 6 31 5 TRUE 2.61
non-small cell lung cancer KRAS_12 TP53 Any mutation 21 71 Signature 7 -1.34 -2.04 -0.63 1569.12 1.00 28 13 63 8 TRUE 3.74
non-small cell lung cancer KRAS_12 TP53 Any mutation 26 35 Signature 8 -1.24 -1.98 -0.56 1338.86 1.00 11 17 26 9 TRUE 3.13
non-small cell lung cancer KRAS_12 TP53 Any mutation 145 85 Signature R2 -1.39 -1.86 -0.89 1517.27 1.00 18 103 43 42 TRUE 7.28
non-small cell lung cancer KRAS_12 TP53 Any mutation 6 15 Signature R3 -1.51 -2.55 -0.57 1393.83 1.00 12 5 14 1 TRUE 2.75
non-small cell lung cancer KRAS_12 TP53 Any mutation 17 57 Signature U1 -1.78 -2.67 -0.99 1519.40 1.00 41 15 55 2 TRUE 4.71
non-small cell lung cancer KRAS_12 TP53 Any mutation 9 32 Signature U2 -1.66 -2.58 -0.82 1413.48 1.00 8 7 30 2 TRUE 3.55
pancreatic cancer KRAS_12 TP53 Any mutation 115 94 Signature 11 1.88 1.05 2.70 1410.53 1.00 5 26 5 89 TRUE 5.22
pancreatic cancer KRAS_12 TP53 Any mutation 109 98 Signature 15 1.45 0.73 2.17 1503.29 1.00 10 25 14 84 TRUE 3.93
pancreatic cancer KRAS_12 TP53 Any mutation 23 19 Signature 16 2.15 1.13 3.25 1371.01 1.00 7 5 1 18 TRUE 4.15
pancreatic cancer KRAS_12 TP53 Any mutation 12 41 Signature 17 0.23 -0.75 1.12 1507.43 1.00 9 5 34 7 TRUE 0.21
pancreatic cancer KRAS_12 TP53 Any mutation 14 14 Signature 18 2.06 1.02 3.13 1471.60 1.00 7 2 2 12 TRUE 3.70
pancreatic cancer KRAS_12 TP53 Any mutation 14 16 Signature 19 1.92 0.94 2.99 1567.69 1.00 8 2 4 12 TRUE 3.61
pancreatic cancer KRAS_12 TP53 Any mutation 201 172 Signature 1A 1.40 0.85 1.91 1504.60 1.00 28 53 24 148 TRUE 6.43
pancreatic cancer KRAS_12 TP53 Any mutation 16 12 Signature 1B 1.88 0.80 3.09 1487.33 1.00 4 5 1 11 TRUE 3.04
pancreatic cancer KRAS_12 TP53 Any mutation 33 29 Signature 2 2.29 1.38 3.31 1445.60 1.00 11 6 2 27 TRUE 5.51
pancreatic cancer KRAS_12 TP53 Any mutation 25 21 Signature 21 2.24 1.26 3.38 1418.47 1.00 6 5 1 20 TRUE 4.39
pancreatic cancer KRAS_12 TP53 Any mutation 78 66 Signature 3 2.16 1.38 2.96 1491.97 1.00 15 17 5 61 TRUE 7.13
pancreatic cancer KRAS_12 TP53 Any mutation 61 58 Signature 4 2.42 1.51 3.36 1396.56 1.00 8 7 4 54 TRUE 6.83
pancreatic cancer KRAS_12 TP53 Any mutation 54 53 Signature 6 1.67 0.87 2.54 1333.36 1.00 10 11 10 43 TRUE 4.09
pancreatic cancer KRAS_12 TP53 Any mutation 23 25 Signature 7 2.43 1.46 3.54 1418.94 1.00 9 1 3 22 TRUE 5.30
pancreatic cancer KRAS_12 TP53 Any mutation 49 37 Signature 8 2.28 1.29 3.34 1335.80 1.00 3 12 0 37 TRUE 4.94
pancreatic cancer KRAS_12 TP53 Any mutation 21 19 Signature R3 2.30 1.26 3.52 1555.04 1.00 3 3 1 18 TRUE 4.39
pancreatic cancer KRAS_12 TP53 Any mutation 11 11 Signature U1 2.21 1.16 3.36 1405.65 1.00 10 1 1 10 TRUE 4.11
uterine cancer KRAS_12 TP53 Any mutation 19 53 Signature 15 -1.89 -2.87 -1.02 1431.82 1.00 39 16 50 3 TRUE 4.11
uterine cancer KRAS_12 TP53 Any mutation 35 113 Signature 1A -1.43 -2.15 -0.75 1568.42 1.00 92 25 103 10 TRUE 4.12
uterine cancer KRAS_12 TP53 Any mutation 7 19 Signature 20 -1.89 -3.06 -0.87 1143.78 1.00 19 6 18 1 TRUE 3.04
uterine cancer KRAS_12 TP53 Any mutation 10 30 Signature 3 -1.72 -2.75 -0.81 1513.68 1.00 10 7 27 3 TRUE 3.25
uterine cancer KRAS_12 TP53 Any mutation 13 45 Signature 6 -2.23 -3.59 -1.20 1216.99 1.00 49 13 45 0 TRUE 3.53
cancer of unknown primary KRAS_12 TP53 Any mutation 95 287 Signature overall -0.45 -1.06 0.15 1354.02 1.00 130 44 236 51 TRUE 0.82
colorectal cancer KRAS_12 TP53 Any mutation 674 1607 Signature overall -0.88 -1.18 -0.58 1442.06 1.00 336 264 1197 410 TRUE 7.85
non-small cell lung cancer KRAS_12 TP53 Any mutation 836 1927 Signature overall -1.31 -1.64 -1.00 1521.57 1.00 719 511 1602 325 TRUE 15.24
pancreatic cancer KRAS_12 TP53 Any mutation 859 785 Signature overall 1.94 1.44 2.46 1517.62 1.00 153 186 112 673 TRUE 12.46
uterine cancer KRAS_12 TP53 Any mutation 92 356 Signature overall -1.93 -2.77 -1.20 1182.88 1.00 283 75 339 17 TRUE 5.80
colorectal cancer KRAS_12 ATRX Any mutation 8 19 Signature 10 -2.47 -5.61 -0.58 1499.52 1.00 18 8 19 0 TRUE 1.22
colorectal cancer KRAS_12 ATRX Any mutation 270 46 Signature 1A -0.68 -1.42 0.00 1481.01 1.00 545 260 36 10 TRUE 1.19
colorectal cancer KRAS_12 ATRX Any mutation 69 29 Signature 6 -1.13 -2.31 -0.08 1321.87 1.00 219 66 26 3 TRUE 1.28
non-small cell lung cancer KRAS_12 ATRX Any mutation 58 12 Signature 18 0.12 -0.58 0.89 1499.75 1.00 87 52 6 6 TRUE 0.13
non-small cell lung cancer KRAS_12 ATRX Any mutation 79 28 Signature 2 0.08 -0.58 0.73 1778.05 1.00 228 71 20 8 TRUE 0.09
non-small cell lung cancer KRAS_12 ATRX Any mutation 234 88 Signature 4 -0.01 -0.48 0.43 1515.10 1.00 423 207 61 27 TRUE 0.02
uterine cancer KRAS_12 ATRX Any mutation 34 12 Signature 1A -4.00 -9.06 -0.75 1506.22 1.00 173 34 12 0 TRUE 1.20
uterine cancer KRAS_12 ATRX Any mutation 13 13 Signature 6 -3.90 -8.68 -0.76 1577.43 1.00 75 13 13 0 TRUE 1.25
colorectal cancer KRAS_12 ATRX Any mutation 347 94 Signature overall -1.42 -3.38 0.16 1554.77 1.00 782 334 81 13 TRUE 0.94
non-small cell lung cancer KRAS_12 ATRX Any mutation 371 128 Signature overall 0.07 -0.56 0.74 1518.57 1.00 738 330 87 41 TRUE 0.08
uterine cancer KRAS_12 ATRX Any mutation 51 123 Signature overall -3.40 -6.85 -0.50 1423.60 1.00 274 50 122 1 TRUE 1.48
colorectal cancer KRAS_12 ATR Any mutation 8 28 Signature 10 -1.96 -3.84 -0.37 1291.86 1.00 17 7 27 1 FALSE 1.66
colorectal cancer KRAS_12 ATR Any mutation 99 12 Signature 15 -1.54 -3.42 -0.10 1420.89 1.00 278 98 11 1 FALSE 1.15
colorectal cancer KRAS_12 ATR Any mutation 270 32 Signature 1A -0.90 -1.88 -0.07 1390.21 1.00 550 264 26 6 FALSE 1.29
colorectal cancer KRAS_12 ATR Any mutation 71 28 Signature 6 -0.82 -1.99 0.22 1703.82 1.00 225 67 24 4 FALSE 0.86
non-small cell lung cancer KRAS_12 ATR Any mutation 13 11 Signature 13 -0.21 -1.42 0.96 1284.40 1.00 76 11 9 2 FALSE 0.14
non-small cell lung cancer KRAS_12 ATR Any mutation 79 16 Signature 2 -0.25 -1.23 0.69 1477.61 1.00 233 75 12 4 FALSE 0.22
non-small cell lung cancer KRAS_12 ATR Any mutation 230 60 Signature 4 -0.61 -1.24 -0.03 1042.77 1.00 426 218 48 12 FALSE 1.28
colorectal cancer KRAS_12 ATR Any mutation 448 100 Signature overall -1.29 -2.76 0.16 1414.22 1.00 1070 436 88 12 FALSE 1.09
non-small cell lung cancer KRAS_12 ATR Any mutation 322 87 Signature overall -0.35 -1.35 0.67 1259.20 1.00 735 304 69 18 FALSE 0.32
non-small cell lung cancer KRAS_12 PDGFRA Any mutation 79 20 Signature 2 -0.13 -0.95 0.67 1561.42 1.00 230 74 15 5 TRUE 0.13
non-small cell lung cancer KRAS_12 PDGFRA Any mutation 232 70 Signature 4 -0.18 -0.70 0.34 1285.85 1.00 426 212 50 20 TRUE 0.30
non-small cell lung cancer KRAS_12 PDGFRA Any mutation 311 90 Signature overall -0.16 -1.22 0.95 1534.25 1.00 656 286 65 25 TRUE 0.12
colorectal cancer KRAS_12 FBXW7 Any mutation 8 17 Signature 10 -0.13 -1.29 0.75 1513.72 1.00 14 6 15 2 TRUE 0.10
colorectal cancer KRAS_12 FBXW7 Any mutation 102 48 Signature 15 0.17 -0.42 0.75 1363.64 1.00 257 87 33 15 TRUE 0.25
colorectal cancer KRAS_12 FBXW7 Any mutation 280 144 Signature 1A 0.16 -0.18 0.52 1502.03 1.00 493 229 93 51 TRUE 0.41
colorectal cancer KRAS_12 FBXW7 Any mutation 73 78 Signature 6 0.30 -0.21 0.80 1554.65 1.00 190 51 56 22 TRUE 0.60
uterine cancer KRAS_12 FBXW7 Any mutation 19 17 Signature 15 -0.41 -1.78 0.75 1477.95 1.00 75 17 15 2 TRUE 0.29
uterine cancer KRAS_12 FBXW7 Any mutation 34 35 Signature 1A 0.02 -0.84 0.84 1220.85 1.00 157 28 29 6 TRUE 0.01
uterine cancer KRAS_12 FBXW7 Any mutation 13 18 Signature 6 -0.27 -1.52 0.95 1346.25 1.00 68 11 16 2 TRUE 0.17
colorectal cancer KRAS_12 FBXW7 Any mutation 463 287 Signature overall 0.13 -0.56 0.78 1584.83 1.00 954 373 197 90 TRUE 0.16
uterine cancer KRAS_12 FBXW7 Any mutation 69 101 Signature overall -0.10 -1.17 1.14 1463.36 1.00 318 56 88 13 TRUE 0.06
uterine cancer KRAS_12 NSD1 Any mutation 35 22 Signature 1A 0.16 -0.98 1.21 1551.67 1.00 170 31 18 4 FALSE 0.11
uterine cancer KRAS_12 NSD1 Any mutation 16 29 Signature 6 0.82 -0.27 1.88 1432.87 1.00 69 9 22 7 FALSE 0.90
uterine cancer KRAS_12 NSD1 Any mutation 53 88 Signature overall 0.50 -1.35 2.36 1459.33 1.00 256 40 75 13 FALSE 0.22
colorectal cancer KRAS_12 FLT4 Any mutation 8 14 Signature 10 -0.95 -2.77 0.46 1408.08 1.00 20 7 13 1 TRUE 0.64
colorectal cancer KRAS_12 FLT4 Any mutation 100 14 Signature 15 0.25 -0.75 1.33 1480.89 1.00 278 94 8 6 TRUE 0.19
colorectal cancer KRAS_12 FLT4 Any mutation 273 54 Signature 1A -0.21 -0.86 0.36 1118.90 1.00 538 257 38 16 TRUE 0.32
colorectal cancer KRAS_12 FLT4 Any mutation 69 51 Signature 6 -1.18 -2.21 -0.34 1446.26 1.00 201 65 47 4 TRUE 1.83
non-small cell lung cancer KRAS_12 FLT4 Any mutation 79 11 Signature 2 -0.81 -2.39 0.22 434.51 1.01 235 78 10 1 TRUE 0.66
non-small cell lung cancer KRAS_12 FLT4 Any mutation 230 36 Signature 4 -0.48 -1.32 0.20 729.32 1.00 447 221 27 9 TRUE 0.68
colorectal cancer KRAS_12 FLT4 Any mutation 450 133 Signature overall -0.52 -1.71 0.63 1484.76 1.00 1037 423 106 27 TRUE 0.44
non-small cell lung cancer KRAS_12 FLT4 Any mutation 309 47 Signature overall -0.63 -2.23 0.49 1048.82 1.00 682 299 37 10 TRUE 0.42
colorectal cancer KRAS_12 PTPRD Any mutation 8 19 Signature 10 -1.33 -3.06 0.01 1462.98 1.00 19 7 18 1 FALSE 1.06
colorectal cancer KRAS_12 PTPRD Any mutation 99 14 Signature 15 0.08 -1.04 1.15 1346.90 1.00 279 94 9 5 FALSE 0.05
colorectal cancer KRAS_12 PTPRD Any mutation 270 31 Signature 1A -0.60 -1.45 0.17 1564.10 1.00 554 263 24 7 FALSE 0.83
colorectal cancer KRAS_12 PTPRD Any mutation 69 31 Signature 6 -1.03 -2.26 -0.05 1487.85 1.00 219 66 28 3 FALSE 1.17
non-small cell lung cancer KRAS_12 PTPRD Any mutation 60 22 Signature 18 0.55 -0.25 1.30 1437.35 1.00 83 48 10 12 FALSE 0.76
non-small cell lung cancer KRAS_12 PTPRD Any mutation 44 12 Signature 1A 0.17 -0.89 1.18 1335.32 1.00 213 41 9 3 FALSE 0.13
non-small cell lung cancer KRAS_12 PTPRD Any mutation 79 33 Signature 2 0.13 -0.64 0.84 1386.53 1.00 222 70 24 9 FALSE 0.14
non-small cell lung cancer KRAS_12 PTPRD Any mutation 13 12 Signature 20 0.00 -1.15 1.09 1520.53 1.00 56 11 10 2 FALSE 0.00
non-small cell lung cancer KRAS_12 PTPRD Any mutation 50 18 Signature 3 0.40 -0.50 1.27 1414.52 1.00 181 44 12 6 FALSE 0.42
non-small cell lung cancer KRAS_12 PTPRD Any mutation 240 195 Signature 4 -0.25 -0.61 0.09 1584.52 1.00 366 186 141 54 FALSE 0.80
non-small cell lung cancer KRAS_12 PTPRD Any mutation 145 18 Signature R2 -0.32 -1.14 0.51 1470.43 1.00 48 134 7 11 FALSE 0.35
non-small cell lung cancer KRAS_12 PTPRD Any mutation 9 11 Signature U2 -0.01 -1.20 1.11 1324.78 1.00 28 7 9 2 FALSE 0.01
colorectal cancer KRAS_12 PTPRD Any mutation 446 95 Signature overall -0.73 -2.01 0.58 1414.75 1.00 1071 430 79 16 FALSE 0.57
non-small cell lung cancer KRAS_12 PTPRD Any mutation 640 321 Signature overall 0.09 -0.53 0.78 1430.83 1.00 1197 541 222 99 FALSE 0.11
non-small cell lung cancer KRAS_12 PIK3C2G Any mutation 79 17 Signature 2 -0.92 -2.04 0.05 1496.82 1.00 229 77 15 2 FALSE 1.08
non-small cell lung cancer KRAS_12 PIK3C2G Any mutation 230 57 Signature 4 -0.81 -1.46 -0.17 1539.75 1.00 430 219 46 11 FALSE 1.82
non-small cell lung cancer KRAS_12 PIK3C2G Any mutation 309 74 Signature overall -0.84 -2.07 0.27 1462.00 1.00 659 296 61 13 FALSE 0.81
colorectal cancer KRAS_12 CREBBP Any mutation 8 15 Signature 10 -1.10 -2.72 0.28 1528.49 1.00 19 7 14 1 TRUE 0.82
colorectal cancer KRAS_12 CREBBP Any mutation 99 27 Signature 15 -0.83 -1.80 0.08 1579.32 1.00 268 95 23 4 TRUE 1.05
colorectal cancer KRAS_12 CREBBP Any mutation 273 45 Signature 1A -0.03 -0.63 0.56 1475.15 1.00 548 257 29 16 TRUE 0.03
colorectal cancer KRAS_12 CREBBP Any mutation 73 80 Signature 6 -1.22 -2.02 -0.48 1580.88 1.00 189 66 73 7 TRUE 2.72
non-small cell lung cancer KRAS_12 CREBBP Any mutation 44 12 Signature 1A 0.08 -0.77 0.87 1474.04 1.00 213 41 9 3 TRUE 0.08
non-small cell lung cancer KRAS_12 CREBBP Any mutation 79 15 Signature 2 -0.16 -0.99 0.56 1453.64 1.00 232 77 13 2 TRUE 0.16
non-small cell lung cancer KRAS_12 CREBBP Any mutation 50 11 Signature 3 0.06 -0.76 0.80 1546.63 1.00 185 47 8 3 TRUE 0.05
non-small cell lung cancer KRAS_12 CREBBP Any mutation 230 44 Signature 4 0.07 -0.51 0.64 1410.16 1.00 448 215 29 15 TRUE 0.09
colorectal cancer KRAS_12 CREBBP Any mutation 453 167 Signature overall -0.76 -1.86 0.31 1685.77 1.00 1024 425 139 28 TRUE 0.79
non-small cell lung cancer KRAS_12 CREBBP Any mutation 403 82 Signature overall 0.01 -0.68 0.64 1486.90 1.00 1078 380 59 23 TRUE 0.01
colorectal cancer KRAS_12 AXIN2 Any mutation 99 17 Signature 15 -0.19 -1.29 0.81 1599.77 1.00 276 94 12 5 TRUE 0.14
colorectal cancer KRAS_12 AXIN2 Any mutation 270 36 Signature 1A -0.35 -1.07 0.34 1468.08 1.00 553 260 26 10 TRUE 0.47
colorectal cancer KRAS_12 AXIN2 Any mutation 69 40 Signature 6 -2.35 -5.20 -0.83 1436.58 1.00 212 69 40 0 TRUE 1.41
colorectal cancer KRAS_12 AXIN2 Any mutation 438 93 Signature overall -0.92 -2.67 0.51 1288.46 1.00 1041 423 78 15 TRUE 0.63
non-small cell lung cancer KRAS_12 DOT1L Any mutation 79 16 Signature 2 -0.24 -1.21 0.58 1440.19 1.00 232 76 13 3 FALSE 0.23
non-small cell lung cancer KRAS_12 DOT1L Any mutation 230 38 Signature 4 -0.12 -0.78 0.48 1603.80 1.00 447 218 26 12 FALSE 0.15
non-small cell lung cancer KRAS_12 DOT1L Any mutation 309 54 Signature overall -0.18 -1.14 0.72 1576.03 1.00 679 294 39 15 FALSE 0.15
colorectal cancer KRAS_12 PTPRS Any mutation 8 16 Signature 10 -1.45 -3.63 -0.02 1598.46 1.00 16 8 16 0 FALSE 0.93
colorectal cancer KRAS_12 PTPRS Any mutation 96 38 Signature 15 0.10 -0.61 0.78 1320.02 1.00 260 84 26 12 FALSE 0.11
colorectal cancer KRAS_12 PTPRS Any mutation 264 95 Signature 1A -0.07 -0.55 0.37 1516.83 1.00 505 234 65 30 FALSE 0.12
colorectal cancer KRAS_12 PTPRS Any mutation 69 83 Signature 6 -0.90 -1.59 -0.26 1581.63 1.00 185 60 74 9 FALSE 2.03
colorectal cancer KRAS_12 PTPRS Any mutation 437 232 Signature overall -0.57 -1.72 0.32 1356.28 1.00 966 386 181 51 FALSE 0.57
colorectal cancer KRAS_12 SMARCA4 Any mutation 100 22 Signature 15 -0.13 -0.97 0.79 1481.89 1.00 276 93 15 7 FALSE 0.12
colorectal cancer KRAS_12 SMARCA4 Any mutation 273 74 Signature 1A -0.37 -0.90 0.12 1524.65 1.00 531 254 55 19 FALSE 0.81
colorectal cancer KRAS_12 SMARCA4 Any mutation 70 52 Signature 6 -0.95 -1.92 -0.20 1541.77 1.00 208 66 48 4 FALSE 1.56
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 13 11 Signature 13 0.13 -1.02 1.20 1502.63 1.00 76 11 9 2 FALSE 0.09
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 57 14 Signature 18 0.16 -0.72 1.03 1632.32 1.00 86 51 8 6 FALSE 0.14
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 44 17 Signature 1A 0.01 -0.98 0.96 1611.56 1.00 210 41 14 3 FALSE 0.00
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 81 33 Signature 2 -0.01 -0.80 0.69 1446.82 1.00 225 73 25 8 FALSE 0.01
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 50 16 Signature 3 0.66 -0.24 1.55 1425.86 1.00 185 43 9 7 FALSE 0.83
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 231 104 Signature 4 -0.21 -0.64 0.22 1498.06 1.00 403 202 75 29 FALSE 0.45
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 20 15 Signature 7 0.05 -1.00 1.04 1615.90 1.00 76 17 12 3 FALSE 0.04
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 144 15 Signature R2 -0.11 -0.98 0.74 1412.04 1.00 49 134 5 10 FALSE 0.10
uterine cancer KRAS_12 SMARCA4 Any mutation 19 14 Signature 15 -0.38 -1.57 0.78 1576.96 1.00 82 17 12 2 FALSE 0.27
uterine cancer KRAS_12 SMARCA4 Any mutation 34 21 Signature 1A -0.53 -1.69 0.50 1450.77 1.00 168 32 19 2 FALSE 0.47
uterine cancer KRAS_12 SMARCA4 Any mutation 15 30 Signature 6 -0.40 -1.56 0.59 1674.36 1.00 69 12 27 3 FALSE 0.33
colorectal cancer KRAS_12 SMARCA4 Any mutation 443 148 Signature overall -0.47 -1.31 0.43 1613.71 1.00 1015 413 118 30 FALSE 0.54
non-small cell lung cancer KRAS_12 SMARCA4 Any mutation 640 225 Signature overall 0.08 -0.56 0.72 1568.09 1.00 1310 572 157 68 FALSE 0.10
uterine cancer KRAS_12 SMARCA4 Any mutation 69 76 Signature overall -0.39 -1.51 0.66 1498.46 1.00 348 61 68 8 FALSE 0.32
colorectal cancer KRAS_12 PTPRT Any mutation 8 23 Signature 10 -2.43 -4.87 -0.74 1501.07 1.00 16 8 23 0 FALSE 1.56
colorectal cancer KRAS_12 PTPRT Any mutation 99 25 Signature 15 -1.96 -3.72 -0.66 1401.01 1.00 263 98 24 1 FALSE 1.98
colorectal cancer KRAS_12 PTPRT Any mutation 271 66 Signature 1A -0.38 -0.99 0.17 1512.89 1.00 528 253 48 18 FALSE 0.70
colorectal cancer KRAS_12 PTPRT Any mutation 70 43 Signature 6 -0.83 -1.77 0.04 1430.22 1.00 207 64 37 6 FALSE 1.16
non-small cell lung cancer KRAS_12 PTPRT Any mutation 13 11 Signature 13 0.31 -1.02 1.55 1334.05 1.00 79 10 8 3 FALSE 0.19
non-small cell lung cancer KRAS_12 PTPRT Any mutation 57 17 Signature 18 -0.39 -1.34 0.62 1275.95 1.00 82 52 12 5 FALSE 0.36
non-small cell lung cancer KRAS_12 PTPRT Any mutation 44 11 Signature 1A -1.02 -2.73 0.28 1475.34 1.00 214 44 11 0 FALSE 0.74
non-small cell lung cancer KRAS_12 PTPRT Any mutation 80 30 Signature 2 0.69 -0.05 1.40 1515.64 1.00 229 67 17 13 FALSE 1.20
non-small cell lung cancer KRAS_12 PTPRT Any mutation 50 19 Signature 3 -0.68 -1.95 0.38 1242.27 1.01 178 48 17 2 FALSE 0.63
non-small cell lung cancer KRAS_12 PTPRT Any mutation 234 179 Signature 4 -0.80 -1.24 -0.41 1539.60 1.00 366 200 145 34 FALSE 3.92
non-small cell lung cancer KRAS_12 PTPRT Any mutation 146 23 Signature R2 -0.25 -1.08 0.56 1229.78 1.00 49 131 8 15 FALSE 0.27
colorectal cancer KRAS_12 PTPRT Any mutation 448 157 Signature overall -1.39 -2.85 -0.19 1431.58 1.00 1014 423 132 25 FALSE 1.41
non-small cell lung cancer KRAS_12 PTPRT Any mutation 624 290 Signature overall -0.31 -1.13 0.45 1519.65 1.00 1197 552 218 72 FALSE 0.36
non-small cell lung cancer KRAS_12 HGF Any mutation 79 20 Signature 2 0.28 -0.65 1.13 1540.43 1.00 232 72 13 7 FALSE 0.26
non-small cell lung cancer KRAS_12 HGF Any mutation 230 89 Signature 4 -0.43 -0.95 0.05 1520.09 1.00 414 208 67 22 FALSE 1.02
non-small cell lung cancer KRAS_12 HGF Any mutation 145 12 Signature R2 -1.05 -2.14 -0.06 1530.65 1.00 48 140 7 5 FALSE 1.26
non-small cell lung cancer KRAS_12 HGF Any mutation 454 121 Signature overall -0.38 -1.72 0.99 1441.41 1.00 694 420 87 34 FALSE 0.23
colorectal cancer KRAS_12 PIK3CA Any mutation 9 23 Signature 10 0.06 -0.82 0.92 1617.61 1.00 15 5 19 4 TRUE 0.05
colorectal cancer KRAS_12 PIK3CA Any mutation 99 63 Signature 15 0.01 -0.53 0.55 1402.09 1.00 244 83 47 16 TRUE 0.02
colorectal cancer KRAS_12 PIK3CA Any mutation 16 19 Signature 18 0.19 -0.63 1.00 1450.46 1.00 19 10 13 6 TRUE 0.19
colorectal cancer KRAS_12 PIK3CA Any mutation 276 191 Signature 1A 0.36 0.03 0.66 1431.47 1.00 471 202 117 74 TRUE 1.57
colorectal cancer KRAS_12 PIK3CA Any mutation 38 43 Signature 2 0.88 0.23 1.54 1455.99 1.00 29 13 18 25 TRUE 2.06
colorectal cancer KRAS_12 PIK3CA Any mutation 72 95 Signature 6 0.05 -0.46 0.55 1469.65 1.00 180 51 74 21 TRUE 0.07
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 14 13 Signature 13 1.08 -0.06 2.28 1260.66 1.00 78 8 7 6 TRUE 1.20
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 44 13 Signature 1A 0.16 -0.95 1.18 1496.81 1.00 213 41 10 3 TRUE 0.12
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 80 82 Signature 2 0.14 -0.43 0.67 1425.35 1.00 189 59 61 21 TRUE 0.21
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 13 16 Signature 20 0.13 -0.97 1.19 1521.78 1.00 51 10 13 3 TRUE 0.09
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 50 15 Signature 3 -0.89 -2.46 0.27 1429.57 1.00 178 50 15 0 TRUE 0.73
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 230 38 Signature 4 -0.18 -0.83 0.43 1429.53 1.00 446 219 27 11 TRUE 0.24
uterine cancer KRAS_12 PIK3CA Any mutation 22 50 Signature 15 0.32 -0.51 1.13 1513.21 1.00 56 12 40 10 TRUE 0.35
uterine cancer KRAS_12 PIK3CA Any mutation 40 138 Signature 1A 0.86 0.22 1.52 1476.29 1.00 103 11 109 29 TRUE 1.98
uterine cancer KRAS_12 PIK3CA Any mutation 8 25 Signature 20 0.28 -0.84 1.35 1425.99 1.00 15 4 21 4 TRUE 0.20
uterine cancer KRAS_12 PIK3CA Any mutation 11 21 Signature 3 1.34 0.29 2.53 1530.71 1.00 24 2 12 9 TRUE 1.78
uterine cancer KRAS_12 PIK3CA Any mutation 20 85 Signature 6 0.93 0.05 1.87 1405.05 1.00 36 3 68 17 TRUE 1.36
colorectal cancer KRAS_12 PIK3CA Any mutation 510 434 Signature overall 0.27 -0.28 0.78 1449.21 1.00 958 364 288 146 TRUE 0.48
non-small cell lung cancer KRAS_12 PIK3CA Any mutation 431 177 Signature overall 0.07 -0.72 0.79 1461.66 1.00 1155 387 133 44 TRUE 0.06
uterine cancer KRAS_12 PIK3CA Any mutation 112 459 Signature overall 0.47 -0.24 1.18 1394.09 1.00 320 36 383 76 TRUE 0.67
colorectal cancer KRAS_12 ALK Any mutation 8 13 Signature 10 -2.43 -5.86 -0.39 1360.21 1.00 18 8 13 0 TRUE 1.10
colorectal cancer KRAS_12 ALK Any mutation 99 16 Signature 15 0.14 -0.99 1.18 1299.11 1.00 276 93 10 6 TRUE 0.10
colorectal cancer KRAS_12 ALK Any mutation 270 35 Signature 1A -0.62 -1.46 0.14 1410.26 1.00 551 262 27 8 TRUE 0.94
colorectal cancer KRAS_12 ALK Any mutation 69 37 Signature 6 -2.88 -6.02 -1.08 1316.24 1.00 212 69 37 0 TRUE 1.64
non-small cell lung cancer KRAS_12 ALK Any mutation 79 24 Signature 2 0.22 -0.48 1.07 1501.99 1.00 231 71 16 8 TRUE 0.26
non-small cell lung cancer KRAS_12 ALK Any mutation 230 72 Signature 4 0.04 -0.46 0.55 1457.71 1.00 428 207 49 23 TRUE 0.06
colorectal cancer KRAS_12 ALK Any mutation 446 101 Signature overall -1.42 -3.30 0.07 1416.42 1.00 1057 432 87 14 TRUE 1.00
non-small cell lung cancer KRAS_12 ALK Any mutation 309 96 Signature overall 0.14 -0.82 1.25 1255.80 1.00 659 278 65 31 TRUE 0.10
colorectal cancer KRAS_12 RNF43 Any mutation 102 31 Signature 15 -0.30 -1.18 0.59 1451.02 1.00 270 94 23 8 TRUE 0.30
colorectal cancer KRAS_12 RNF43 Any mutation 275 93 Signature 1A -0.76 -1.30 -0.26 1531.28 1.00 524 257 75 18 TRUE 2.32
colorectal cancer KRAS_12 RNF43 Any mutation 69 102 Signature 6 -1.54 -2.40 -0.80 1430.48 1.00 175 63 96 6 TRUE 3.94
colorectal cancer KRAS_12 RNF43 Any mutation 446 226 Signature overall -0.83 -1.98 0.26 1362.24 1.00 969 414 194 32 TRUE 0.85
colorectal cancer KRAS_12 PTEN Any mutation 8 13 Signature 10 -0.90 -2.40 0.37 1470.10 1.00 18 7 12 1 TRUE 0.73
colorectal cancer KRAS_12 PTEN Any mutation 99 22 Signature 15 0.06 -0.85 0.95 1530.98 1.00 273 91 14 8 TRUE 0.05
colorectal cancer KRAS_12 PTEN Any mutation 270 64 Signature 1A -1.04 -1.74 -0.41 1755.45 1.00 536 261 55 9 TRUE 2.68
colorectal cancer KRAS_12 PTEN Any mutation 71 57 Signature 6 -0.77 -1.53 -0.04 1414.13 1.00 210 64 50 7 TRUE 1.33
non-small cell lung cancer KRAS_12 PTEN Any mutation 79 27 Signature 2 -0.76 -1.76 0.14 1276.73 1.00 225 75 23 4 TRUE 0.91
non-small cell lung cancer KRAS_12 PTEN Any mutation 230 27 Signature 4 -0.82 -1.76 0.00 1417.50 1.00 451 225 22 5 TRUE 1.21
uterine cancer KRAS_12 PTEN Any mutation 27 61 Signature 15 1.02 0.30 1.73 1352.66 1.00 61 8 42 19 TRUE 2.24
uterine cancer KRAS_12 PTEN Any mutation 47 155 Signature 1A 0.78 0.21 1.35 1423.28 1.00 114 14 122 33 TRUE 2.03
uterine cancer KRAS_12 PTEN Any mutation 7 26 Signature 2 0.48 -0.45 1.49 1450.01 1.00 25 3 22 4 TRUE 0.48
uterine cancer KRAS_12 PTEN Any mutation 10 28 Signature 20 0.91 0.00 1.90 1573.07 1.00 19 2 20 8 TRUE 1.23
uterine cancer KRAS_12 PTEN Any mutation 13 17 Signature 3 1.22 0.30 2.17 1423.84 1.00 30 4 8 9 TRUE 2.04
uterine cancer KRAS_12 PTEN Any mutation 19 104 Signature 6 0.15 -0.74 0.99 1490.77 1.00 24 6 91 13 TRUE 0.14
colorectal cancer KRAS_12 PTEN Any mutation 448 156 Signature overall -0.65 -1.64 0.29 1446.84 1.00 1037 423 131 25 TRUE 0.74
non-small cell lung cancer KRAS_12 PTEN Any mutation 309 54 Signature overall -0.74 -2.08 0.68 1431.85 1.00 676 300 45 9 TRUE 0.53
uterine cancer KRAS_12 PTEN Any mutation 142 545 Signature overall 0.54 0.00 1.09 1358.31 1.00 346 43 446 99 TRUE 1.23
colorectal cancer KRAS_12 BCOR Any mutation 8 11 Signature 10 -1.20 -3.24 0.55 1400.32 1.00 19 7 10 1 FALSE 0.68
colorectal cancer KRAS_12 BCOR Any mutation 99 13 Signature 15 -0.07 -1.29 1.05 1216.44 1.00 278 95 9 4 FALSE 0.04
colorectal cancer KRAS_12 BCOR Any mutation 270 27 Signature 1A 0.36 -0.41 1.13 1473.05 1.00 560 258 15 12 FALSE 0.45
colorectal cancer KRAS_12 BCOR Any mutation 69 49 Signature 6 -2.95 -5.78 -1.22 1439.85 1.00 207 69 49 0 FALSE 1.93
non-small cell lung cancer KRAS_12 BCOR Any mutation 80 13 Signature 2 0.34 -0.60 1.22 1289.78 1.00 236 76 9 4 FALSE 0.34
non-small cell lung cancer KRAS_12 BCOR Any mutation 233 52 Signature 4 0.52 -0.02 1.05 1440.07 1.00 447 210 29 23 FALSE 1.22
uterine cancer KRAS_12 BCOR Any mutation 34 30 Signature 1A -0.15 -1.23 0.85 1451.10 1.00 161 30 26 4 FALSE 0.11
uterine cancer KRAS_12 BCOR Any mutation 15 23 Signature 6 1.15 -0.03 2.38 1348.83 1.00 72 8 16 7 FALSE 1.22
colorectal cancer KRAS_12 BCOR Any mutation 446 100 Signature overall -0.94 -2.70 0.61 1615.38 1.00 1064 429 83 17 FALSE 0.58
non-small cell lung cancer KRAS_12 BCOR Any mutation 313 65 Signature overall 0.42 -0.74 1.46 1462.72 1.00 683 286 38 27 FALSE 0.32
uterine cancer KRAS_12 BCOR Any mutation 50 83 Signature overall 0.42 -1.32 2.36 1458.17 1.00 255 38 71 12 FALSE 0.18
colorectal cancer KRAS_12 CTNNB1 Any mutation 99 22 Signature 15 0.13 -0.55 0.78 1361.26 1.00 271 93 16 6 TRUE 0.15
colorectal cancer KRAS_12 CTNNB1 Any mutation 273 61 Signature 1A 0.44 -0.04 0.89 1257.77 1.00 542 245 33 28 TRUE 1.16
colorectal cancer KRAS_12 CTNNB1 Any mutation 70 33 Signature 6 0.06 -0.71 0.68 1562.90 1.00 217 64 27 6 TRUE 0.06
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 44 11 Signature 1A -1.33 -2.79 -0.09 1563.10 1.00 212 43 10 1 TRUE 1.29
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 79 14 Signature 2 -1.46 -2.85 -0.29 1382.18 1.00 232 78 13 1 TRUE 1.62
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 50 17 Signature 3 -1.03 -2.26 0.20 1334.03 1.00 179 47 14 3 TRUE 1.03
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 230 16 Signature 4 -1.78 -3.25 -0.62 1489.01 1.00 456 230 16 0 TRUE 2.07
uterine cancer KRAS_12 CTNNB1 Any mutation 19 11 Signature 15 -1.95 -3.91 -0.44 1389.39 1.00 80 19 11 0 TRUE 1.52
uterine cancer KRAS_12 CTNNB1 Any mutation 34 31 Signature 1A -1.60 -3.15 -0.35 1346.65 1.00 157 32 29 2 TRUE 1.57
uterine cancer KRAS_12 CTNNB1 Any mutation 13 19 Signature 6 -1.71 -3.42 -0.30 1372.71 1.00 68 12 18 1 TRUE 1.44
colorectal cancer KRAS_12 CTNNB1 Any mutation 442 116 Signature overall 0.22 -0.46 0.84 1497.94 1.00 1030 402 76 40 TRUE 0.30
non-small cell lung cancer KRAS_12 CTNNB1 Any mutation 403 58 Signature overall -1.39 -2.62 -0.34 1470.23 1.00 1079 398 53 5 TRUE 1.87
uterine cancer KRAS_12 CTNNB1 Any mutation 68 83 Signature overall -1.78 -3.28 -0.53 1403.44 1.00 372 65 80 3 TRUE 1.77
cancer of unknown primary KRAS_12 ARID1A Any mutation 32 22 Signature 1A -0.55 -1.47 0.34 1344.46 1.00 73 27 17 5 TRUE 0.63
cancer of unknown primary KRAS_12 ARID1A Any mutation 6 13 Signature 2 -0.71 -1.94 0.48 1384.67 1.00 38 5 12 1 TRUE 0.64
cancer of unknown primary KRAS_12 ARID1A Any mutation 18 12 Signature 4 -0.67 -1.74 0.37 1453.63 1.00 53 16 10 2 TRUE 0.69
colorectal cancer KRAS_12 ARID1A Any mutation 8 13 Signature 10 -0.92 -2.08 0.11 1472.08 1.00 19 7 12 1 TRUE 1.05
colorectal cancer KRAS_12 ARID1A Any mutation 100 39 Signature 15 -0.92 -1.68 -0.16 1624.57 1.00 267 95 34 5 TRUE 1.82
colorectal cancer KRAS_12 ARID1A Any mutation 277 130 Signature 1A -0.61 -1.04 -0.18 1316.56 1.00 505 248 101 29 TRUE 2.26
colorectal cancer KRAS_12 ARID1A Any mutation 72 99 Signature 6 -0.86 -1.43 -0.31 1563.01 1.00 183 60 87 12 TRUE 2.57
non-small cell lung cancer KRAS_12 ARID1A Any mutation 13 17 Signature 13 -1.10 -2.84 0.23 1501.91 1.00 70 13 17 0 TRUE 0.80
non-small cell lung cancer KRAS_12 ARID1A Any mutation 60 12 Signature 18 0.66 -0.29 1.69 1533.61 1.00 89 52 4 8 TRUE 0.69
non-small cell lung cancer KRAS_12 ARID1A Any mutation 83 52 Signature 2 0.48 -0.13 1.09 1560.64 1.00 216 65 34 18 TRUE 0.93
non-small cell lung cancer KRAS_12 ARID1A Any mutation 50 11 Signature 3 -0.34 -1.62 0.80 1437.61 1.00 184 48 9 2 TRUE 0.24
non-small cell lung cancer KRAS_12 ARID1A Any mutation 231 86 Signature 4 -0.85 -1.44 -0.32 1382.40 1.00 403 216 71 15 TRUE 2.59
non-small cell lung cancer KRAS_12 ARID1A Any mutation 144 13 Signature R2 -0.22 -1.15 0.73 1526.42 1.00 50 135 4 9 TRUE 0.19
pancreatic cancer KRAS_12 ARID1A Any mutation 116 12 Signature 11 -0.13 -1.36 1.46 1429.53 1.00 9 105 1 11 TRUE 0.07
pancreatic cancer KRAS_12 ARID1A Any mutation 203 33 Signature 1A -0.18 -0.99 0.74 1506.67 1.00 45 178 8 25 TRUE 0.17
uterine cancer KRAS_12 ARID1A Any mutation 24 58 Signature 15 1.15 0.34 2.01 1632.07 1.00 62 8 42 16 TRUE 2.23
uterine cancer KRAS_12 ARID1A Any mutation 44 133 Signature 1A 1.07 0.39 1.73 1378.59 1.00 117 13 102 31 TRUE 2.74
uterine cancer KRAS_12 ARID1A Any mutation 8 23 Signature 2 1.77 0.68 3.25 1413.79 1.00 29 0 15 8 TRUE 2.17
uterine cancer KRAS_12 ARID1A Any mutation 8 26 Signature 20 1.39 0.30 2.58 1525.97 1.00 20 1 19 7 TRUE 1.73
uterine cancer KRAS_12 ARID1A Any mutation 18 121 Signature 6 0.94 -0.02 1.97 1388.56 1.00 28 2 105 16 TRUE 1.19
cancer of unknown primary KRAS_12 ARID1A Any mutation 61 58 Signature overall -0.69 -1.70 0.22 1432.84 1.00 180 53 50 8 TRUE 0.80
colorectal cancer KRAS_12 ARID1A Any mutation 457 281 Signature overall -0.83 -1.50 -0.16 1598.64 1.00 974 410 234 47 TRUE 1.81
non-small cell lung cancer KRAS_12 ARID1A Any mutation 581 191 Signature overall -0.22 -1.09 0.65 1479.30 1.00 1012 529 139 52 TRUE 0.21
pancreatic cancer KRAS_12 ARID1A Any mutation 319 45 Signature overall -0.14 -1.73 1.63 1291.11 1.00 54 283 9 36 TRUE 0.06
uterine cancer KRAS_12 ARID1A Any mutation 107 445 Signature overall 0.99 0.22 1.77 1591.69 1.00 284 26 364 81 TRUE 1.90
colorectal cancer KRAS_12 PIK3R1 Any mutation 10 17 Signature 10 -0.37 -1.81 0.82 1611.21 1.00 17 7 14 3 TRUE 0.25
colorectal cancer KRAS_12 PIK3R1 Any mutation 99 17 Signature 15 0.41 -0.52 1.37 1530.45 1.00 279 92 10 7 TRUE 0.41
colorectal cancer KRAS_12 PIK3R1 Any mutation 271 31 Signature 1A -0.22 -0.97 0.49 1565.14 1.00 555 262 22 9 TRUE 0.25
colorectal cancer KRAS_12 PIK3R1 Any mutation 69 31 Signature 6 -0.89 -2.04 0.09 1572.09 1.00 218 66 28 3 TRUE 0.97
uterine cancer KRAS_12 PIK3R1 Any mutation 21 32 Signature 15 -0.10 -0.92 0.88 903.38 1.00 71 12 23 9 TRUE 0.08
uterine cancer KRAS_12 PIK3R1 Any mutation 35 59 Signature 1A -0.80 -1.66 -0.07 1124.90 1.00 137 31 55 4 TRUE 1.33
uterine cancer KRAS_12 PIK3R1 Any mutation 7 13 Signature 20 -0.52 -1.49 0.42 1506.29 1.00 25 5 11 2 TRUE 0.58
uterine cancer KRAS_12 PIK3R1 Any mutation 13 31 Signature 6 -0.93 -2.25 -0.04 1393.70 1.00 61 13 31 0 TRUE 0.99
colorectal cancer KRAS_12 PIK3R1 Any mutation 449 96 Signature overall -0.26 -1.44 0.93 1645.63 1.00 1069 427 74 22 TRUE 0.18
uterine cancer KRAS_12 PIK3R1 Any mutation 81 167 Signature overall -0.60 -1.31 0.05 1273.35 1.00 333 64 150 17 TRUE 1.02
colorectal cancer KRAS_12 FAT1 Any mutation 10 44 Signature 10 -1.47 -2.82 -0.32 1291.39 1.00 16 7 41 3 FALSE 1.69
colorectal cancer KRAS_12 FAT1 Any mutation 99 29 Signature 15 -1.55 -2.84 -0.43 1543.88 1.00 268 97 27 2 FALSE 2.03
colorectal cancer KRAS_12 FAT1 Any mutation 274 66 Signature 1A -0.60 -1.24 0.01 1152.91 1.00 533 259 51 15 FALSE 1.30
colorectal cancer KRAS_12 FAT1 Any mutation 70 67 Signature 6 -0.77 -1.49 -0.09 1303.60 1.00 200 61 58 9 FALSE 1.42
non-small cell lung cancer KRAS_12 FAT1 Any mutation 13 16 Signature 13 0.08 -0.93 0.99 1472.23 1.00 73 11 14 2 FALSE 0.06
non-small cell lung cancer KRAS_12 FAT1 Any mutation 57 16 Signature 18 0.52 -0.21 1.30 1380.16 1.00 86 48 7 9 FALSE 0.72
non-small cell lung cancer KRAS_12 FAT1 Any mutation 44 13 Signature 1A 0.36 -0.55 1.26 1418.97 1.00 216 40 9 4 FALSE 0.36
non-small cell lung cancer KRAS_12 FAT1 Any mutation 81 38 Signature 2 0.13 -0.53 0.78 1610.52 1.00 221 71 28 10 FALSE 0.16
non-small cell lung cancer KRAS_12 FAT1 Any mutation 14 11 Signature 20 0.52 -0.43 1.52 1601.87 1.00 57 10 7 4 FALSE 0.53
non-small cell lung cancer KRAS_12 FAT1 Any mutation 50 13 Signature 3 0.25 -0.64 1.13 1455.46 1.00 184 46 9 4 FALSE 0.24
non-small cell lung cancer KRAS_12 FAT1 Any mutation 232 121 Signature 4 -0.45 -0.88 -0.02 1354.61 1.00 390 205 94 27 FALSE 1.42
uterine cancer KRAS_12 FAT1 Any mutation 19 14 Signature 15 -1.07 -3.00 0.47 1573.42 1.00 80 18 13 1 FALSE 0.66
uterine cancer KRAS_12 FAT1 Any mutation 34 24 Signature 1A -0.86 -2.44 0.40 1463.07 1.00 167 32 22 2 FALSE 0.63
uterine cancer KRAS_12 FAT1 Any mutation 13 37 Signature 6 0.04 -1.19 1.21 1542.98 1.00 65 8 32 5 FALSE 0.02
colorectal cancer KRAS_12 FAT1 Any mutation 453 206 Signature overall -1.09 -2.25 0.04 1536.97 1.00 1017 424 177 29 FALSE 1.21
non-small cell lung cancer KRAS_12 FAT1 Any mutation 491 228 Signature overall 0.19 -0.37 0.79 1658.26 1.00 1227 431 168 60 FALSE 0.28
uterine cancer KRAS_12 FAT1 Any mutation 69 149 Signature overall -0.52 -2.19 1.23 1570.00 1.00 324 58 138 11 FALSE 0.28
colorectal cancer KRAS_12 CIC Any mutation 100 19 Signature 15 -0.49 -1.29 0.33 1333.30 1.00 277 96 15 4 TRUE 0.61
colorectal cancer KRAS_12 CIC Any mutation 271 58 Signature 1A -0.38 -0.95 0.13 1397.35 1.00 541 256 43 15 TRUE 0.79
colorectal cancer KRAS_12 CIC Any mutation 70 43 Signature 6 -0.66 -1.47 0.07 1514.31 1.00 214 65 38 5 TRUE 1.03
colorectal cancer KRAS_12 CIC Any mutation 441 120 Signature overall -0.52 -1.27 0.26 1514.48 1.00 1032 417 96 24 TRUE 0.70
colorectal cancer KRAS_12 NCOR1 Any mutation 8 16 Signature 10 -1.18 -2.76 0.07 1200.85 1.00 17 7 15 1 FALSE 0.98
colorectal cancer KRAS_12 NCOR1 Any mutation 99 22 Signature 15 -0.49 -1.41 0.40 1390.44 1.00 272 94 17 5 FALSE 0.53
colorectal cancer KRAS_12 NCOR1 Any mutation 272 44 Signature 1A -0.74 -1.49 -0.06 1608.52 1.00 545 263 35 9 FALSE 1.38
colorectal cancer KRAS_12 NCOR1 Any mutation 69 43 Signature 6 -1.05 -2.05 -0.22 1417.08 1.00 213 65 39 4 FALSE 1.58
non-small cell lung cancer KRAS_12 NCOR1 Any mutation 14 14 Signature 13 0.05 -1.23 1.35 1514.77 1.00 77 11 11 3 FALSE 0.03
non-small cell lung cancer KRAS_12 NCOR1 Any mutation 79 11 Signature 2 -0.22 -1.49 0.95 1332.43 1.00 240 76 8 3 FALSE 0.14
non-small cell lung cancer KRAS_12 NCOR1 Any mutation 231 36 Signature 4 -0.94 -1.86 -0.15 1274.08 1.00 442 226 31 5 FALSE 1.48
colorectal cancer KRAS_12 NCOR1 Any mutation 448 125 Signature overall -0.84 -1.92 0.20 1762.17 1.00 1047 429 106 19 FALSE 0.94
non-small cell lung cancer KRAS_12 NCOR1 Any mutation 324 61 Signature overall -0.37 -1.55 0.86 1367.04 1.00 759 313 50 11 FALSE 0.25
colorectal cancer KRAS_12 POLE Any mutation 8 20 Signature 10 -1.58 -3.41 -0.05 1498.27 1.00 15 7 19 1 TRUE 1.19
colorectal cancer KRAS_12 POLE Any mutation 99 19 Signature 15 -0.51 -1.68 0.50 1322.53 1.00 275 95 15 4 TRUE 0.46
colorectal cancer KRAS_12 POLE Any mutation 271 36 Signature 1A -0.11 -0.81 0.57 1234.59 1.00 555 259 24 12 TRUE 0.11
colorectal cancer KRAS_12 POLE Any mutation 69 54 Signature 6 -1.61 -2.85 -0.61 1474.73 1.00 201 66 51 3 TRUE 2.43
non-small cell lung cancer KRAS_12 POLE Any mutation 80 19 Signature 2 0.21 -0.74 1.10 1573.17 1.00 233 74 13 6 TRUE 0.18
non-small cell lung cancer KRAS_12 POLE Any mutation 230 49 Signature 4 -0.39 -1.06 0.20 1356.93 1.00 438 218 37 12 TRUE 0.64
non-small cell lung cancer KRAS_12 POLE Any mutation 144 11 Signature R2 0.30 -0.77 1.49 1351.95 1.00 52 135 2 9 TRUE 0.22
uterine cancer KRAS_12 POLE Any mutation 34 12 Signature 1A 0.42 -1.06 1.68 1253.41 1.00 177 31 9 3 TRUE 0.27
uterine cancer KRAS_12 POLE Any mutation 13 20 Signature 6 0.17 -1.38 1.53 1604.98 1.00 74 10 17 3 TRUE 0.08
colorectal cancer KRAS_12 POLE Any mutation 447 129 Signature overall -0.91 -2.37 0.40 1495.06 1.00 1046 427 109 20 TRUE 0.70
non-small cell lung cancer KRAS_12 POLE Any mutation 454 79 Signature overall 0.04 -1.16 1.35 1435.51 1.00 723 427 52 27 TRUE 0.02
uterine cancer KRAS_12 POLE Any mutation 49 89 Signature overall 0.32 -2.14 2.73 1185.35 1.00 262 41 81 8 TRUE 0.10
non-small cell lung cancer KRAS_12 NOTCH2 Any mutation 79 15 Signature 2 -0.95 -2.08 0.10 1228.27 1.00 230 77 13 2 TRUE 1.05
non-small cell lung cancer KRAS_12 NOTCH2 Any mutation 230 54 Signature 4 -0.92 -1.65 -0.25 1605.76 1.00 437 221 45 9 TRUE 2.00
non-small cell lung cancer KRAS_12 NOTCH2 Any mutation 309 69 Signature overall -0.94 -2.15 0.29 1324.42 1.00 667 298 58 11 TRUE 0.89
colorectal cancer KRAS_12 TGFBR2 Any mutation 100 11 Signature 15 -0.56 -1.70 0.43 1648.17 1.00 277 98 9 2 TRUE 0.52
colorectal cancer KRAS_12 TGFBR2 Any mutation 271 48 Signature 1A -0.24 -0.84 0.39 1441.79 1.00 544 257 34 14 TRUE 0.35
colorectal cancer KRAS_12 TGFBR2 Any mutation 69 43 Signature 6 -0.55 -1.36 0.19 1411.78 1.00 207 63 37 6 TRUE 0.77
colorectal cancer KRAS_12 TGFBR2 Any mutation 440 102 Signature overall -0.44 -1.45 0.49 1378.42 1.00 1028 418 80 22 TRUE 0.43
colorectal cancer KRAS_12 KMT2A Any mutation 9 22 Signature 10 -1.20 -2.64 0.05 1466.24 1.00 20 7 20 2 FALSE 1.07
colorectal cancer KRAS_12 KMT2A Any mutation 99 19 Signature 15 -1.64 -3.31 -0.41 1379.04 1.00 271 98 18 1 FALSE 1.63
colorectal cancer KRAS_12 KMT2A Any mutation 270 53 Signature 1A -0.14 -0.79 0.44 1344.29 1.00 544 253 36 17 FALSE 0.19
colorectal cancer KRAS_12 KMT2A Any mutation 69 42 Signature 6 -1.71 -3.10 -0.60 1257.57 1.00 212 67 40 2 FALSE 2.17
non-small cell lung cancer KRAS_12 KMT2A Any mutation 79 23 Signature 2 -0.13 -0.93 0.74 1534.70 1.00 230 73 17 6 FALSE 0.12
non-small cell lung cancer KRAS_12 KMT2A Any mutation 230 37 Signature 4 -0.36 -1.04 0.28 1337.27 1.00 445 221 28 9 FALSE 0.54
uterine cancer KRAS_12 KMT2A Any mutation 34 13 Signature 1A -0.37 -2.22 1.14 1212.38 1.00 174 32 11 2 FALSE 0.18
uterine cancer KRAS_12 KMT2A Any mutation 13 14 Signature 6 -2.48 -6.88 -0.02 1429.97 1.00 71 13 14 0 FALSE 0.78
colorectal cancer KRAS_12 KMT2A Any mutation 447 136 Signature overall -1.13 -2.44 0.10 1384.06 1.00 1047 425 114 22 FALSE 1.17
non-small cell lung cancer KRAS_12 KMT2A Any mutation 309 60 Signature overall -0.25 -1.23 0.71 1386.28 1.00 675 294 45 15 FALSE 0.21
uterine cancer KRAS_12 KMT2A Any mutation 49 81 Signature overall -0.84 -3.62 1.88 1622.86 1.00 263 45 77 4 FALSE 0.26
non-small cell lung cancer KRAS_12 PAK7 Any mutation 230 69 Signature 4 -0.61 -1.20 -0.04 1338.75 1.00 425 215 54 15 FALSE 1.37
non-small cell lung cancer KRAS_12 PAK7 Any mutation 230 69 Signature overall -0.65 -5.14 3.43 1326.65 1.00 425 215 54 15 FALSE 0.13
non-small cell lung cancer KRAS_12 STAG2 Any mutation 79 16 Signature 2 0.06 -0.85 0.83 1418.32 1.00 234 75 12 4 TRUE 0.06
non-small cell lung cancer KRAS_12 STAG2 Any mutation 231 43 Signature 4 0.18 -0.41 0.76 1149.92 1.00 448 215 27 16 TRUE 0.26
non-small cell lung cancer KRAS_12 STAG2 Any mutation 310 59 Signature overall 0.13 -0.77 0.98 1156.62 1.00 682 290 39 20 TRUE 0.11
non-small cell lung cancer KRAS_12 TERT Any mutation 80 23 Signature 2 0.76 -0.06 1.68 1494.23 1.00 233 69 12 11 TRUE 1.03
non-small cell lung cancer KRAS_12 TERT Any mutation 231 54 Signature 4 -0.01 -0.64 0.57 1073.36 1.00 438 215 38 16 TRUE 0.02
non-small cell lung cancer KRAS_12 TERT Any mutation 311 77 Signature overall 0.35 -0.94 1.64 1546.34 1.00 671 284 50 27 TRUE 0.25
colorectal cancer KRAS_12 BRCA2 Any mutation 8 37 Signature 10 -3.21 -6.07 -1.25 1344.90 1.00 17 8 37 0 TRUE 1.98
colorectal cancer KRAS_12 BRCA2 Any mutation 99 17 Signature 15 -0.89 -2.25 0.30 1420.03 1.00 277 96 14 3 TRUE 0.75
colorectal cancer KRAS_12 BRCA2 Any mutation 271 50 Signature 1A -0.53 -1.21 0.12 1389.65 1.00 545 259 38 12 TRUE 0.93
colorectal cancer KRAS_12 BRCA2 Any mutation 69 62 Signature 6 -2.31 -3.89 -1.11 1349.59 1.00 201 67 60 2 TRUE 3.05
non-small cell lung cancer KRAS_12 BRCA2 Any mutation 13 13 Signature 13 -1.31 -3.69 0.19 1506.10 1.00 74 13 13 0 TRUE 0.72
non-small cell lung cancer KRAS_12 BRCA2 Any mutation 79 15 Signature 2 -1.24 -2.91 -0.05 1417.76 1.00 232 78 14 1 TRUE 1.05
non-small cell lung cancer KRAS_12 BRCA2 Any mutation 231 55 Signature 4 -0.34 -0.94 0.26 1533.51 1.00 439 215 39 16 TRUE 0.56
uterine cancer KRAS_12 BRCA2 Any mutation 34 15 Signature 1A 0.03 -1.55 1.25 1408.88 1.00 173 31 12 3 TRUE 0.01
uterine cancer KRAS_12 BRCA2 Any mutation 13 22 Signature 6 -2.87 -7.28 -0.33 1375.91 1.00 69 13 22 0 TRUE 0.90
colorectal cancer KRAS_12 BRCA2 Any mutation 447 166 Signature overall -1.71 -3.46 -0.20 1443.63 1.00 1040 430 149 17 TRUE 1.38
non-small cell lung cancer KRAS_12 BRCA2 Any mutation 323 83 Signature overall -0.93 -2.48 0.32 1524.69 1.00 745 306 66 17 TRUE 0.76
uterine cancer KRAS_12 BRCA2 Any mutation 49 102 Signature overall -0.85 -3.79 2.28 1375.88 1.00 257 44 97 5 TRUE 0.25
colorectal cancer KRAS_12 NOTCH3 Any mutation 99 27 Signature 15 -0.36 -1.26 0.51 1486.56 1.00 271 92 20 7 TRUE 0.36
colorectal cancer KRAS_12 NOTCH3 Any mutation 271 70 Signature 1A -0.94 -1.57 -0.34 1470.09 1.00 528 259 58 12 TRUE 2.46
colorectal cancer KRAS_12 NOTCH3 Any mutation 69 72 Signature 6 -1.97 -3.27 -0.97 1581.59 1.00 192 67 70 2 TRUE 3.13
non-small cell lung cancer KRAS_12 NOTCH3 Any mutation 57 11 Signature 18 0.06 -0.70 0.99 1142.81 1.00 89 51 5 6 TRUE 0.05
non-small cell lung cancer KRAS_12 NOTCH3 Any mutation 79 15 Signature 2 -0.25 -1.07 0.53 1261.03 1.00 234 76 12 3 TRUE 0.26
non-small cell lung cancer KRAS_12 NOTCH3 Any mutation 230 48 Signature 4 -0.34 -0.99 0.23 1398.72 1.00 440 219 37 11 TRUE 0.55
colorectal cancer KRAS_12 NOTCH3 Any mutation 439 169 Signature overall -1.09 -2.29 0.04 1471.54 1.00 991 418 148 21 TRUE 1.22
non-small cell lung cancer KRAS_12 NOTCH3 Any mutation 366 74 Signature overall -0.17 -0.91 0.57 1295.49 1.00 763 346 54 20 TRUE 0.19
colorectal cancer KRAS_12 NOTCH4 Any mutation 95 18 Signature 15 -0.61 -1.49 0.21 1376.91 1.00 269 92 15 3 TRUE 0.77
colorectal cancer KRAS_12 NOTCH4 Any mutation 261 43 Signature 1A -0.53 -1.21 0.11 1540.24 1.00 532 251 33 10 TRUE 0.94
colorectal cancer KRAS_12 NOTCH4 Any mutation 67 41 Signature 6 -0.53 -1.35 0.19 1564.05 1.00 207 61 35 6 TRUE 0.76
non-small cell lung cancer KRAS_12 NOTCH4 Any mutation 230 74 Signature 4 -0.39 -0.96 0.17 1088.85 1.00 423 211 55 19 TRUE 0.77
colorectal cancer KRAS_12 NOTCH4 Any mutation 423 102 Signature overall -0.56 -1.44 0.22 1571.54 1.00 1008 404 83 19 TRUE 0.73
non-small cell lung cancer KRAS_12 NOTCH4 Any mutation 230 74 Signature overall -0.39 -4.51 4.03 1586.31 1.00 423 211 55 19 TRUE 0.07
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 13 20 Signature 13 -0.11 -1.13 0.89 1539.34 1.00 67 11 18 2 FALSE 0.08
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 17 12 Signature 14 0.02 -0.96 0.92 1535.30 1.00 30 14 9 3 FALSE 0.02
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 20 16 Signature 15 0.35 -0.56 1.27 1450.13 1.00 105 16 12 4 FALSE 0.35
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 8 12 Signature 16 0.16 -0.85 1.13 1389.75 1.00 42 6 10 2 FALSE 0.12
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 58 34 Signature 18 -0.07 -0.80 0.60 1353.06 1.00 71 47 23 11 FALSE 0.07
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 15 11 Signature 19 0.42 -0.52 1.37 1611.26 1.00 41 11 7 4 FALSE 0.40
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 44 27 Signature 1A 0.53 -0.25 1.32 995.40 1.00 205 36 19 8 FALSE 0.75
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 79 55 Signature 2 -0.09 -0.71 0.51 1547.69 1.00 205 67 43 12 FALSE 0.12
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 13 13 Signature 20 0.24 -0.71 1.22 1382.40 1.00 54 10 10 3 FALSE 0.21
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 50 31 Signature 3 0.48 -0.21 1.18 1430.54 1.00 172 40 21 10 FALSE 0.72
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 232 175 Signature 4 -0.19 -0.56 0.15 1465.94 1.00 352 182 125 50 FALSE 0.52
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 20 14 Signature 7 -0.33 -1.39 0.64 1504.82 1.00 76 19 13 1 FALSE 0.28
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 145 45 Signature R2 0.08 -0.52 0.72 1452.06 1.00 41 114 14 31 FALSE 0.10
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 17 11 Signature U1 1.13 0.18 2.12 1607.80 1.00 90 10 4 7 FALSE 1.73
non-small cell lung cancer KRAS_12 KEAP1 Any mutation 731 476 Signature overall 0.19 -0.25 0.63 1425.95 1.00 1551 583 328 148 FALSE 0.40
non-small cell lung cancer KRAS_12 KDM5C Any mutation 79 15 Signature 2 -0.21 -1.66 0.80 1333.69 1.00 233 77 13 2 FALSE 0.13
non-small cell lung cancer KRAS_12 KDM5C Any mutation 231 41 Signature 4 0.45 -0.18 1.10 1409.39 1.00 451 212 22 19 FALSE 0.78
non-small cell lung cancer KRAS_12 KDM5C Any mutation 310 56 Signature overall 0.11 -1.44 1.25 1534.88 1.00 684 289 35 21 FALSE 0.06
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 13 12 Signature 13 -0.96 -2.73 0.45 1461.78 1.00 73 13 12 0 TRUE 0.64
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 20 11 Signature 15 -0.54 -1.88 0.66 1599.83 1.00 106 19 10 1 TRUE 0.37
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 44 18 Signature 1A 0.49 -0.54 1.46 1377.94 1.00 210 38 12 6 TRUE 0.48
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 79 22 Signature 2 -1.21 -2.56 -0.12 1457.23 1.00 225 78 21 1 TRUE 1.30
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 51 20 Signature 3 0.21 -0.71 1.07 1501.38 1.00 179 45 14 6 TRUE 0.19
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 233 90 Signature 4 -0.57 -1.12 -0.06 1468.39 1.00 407 213 70 20 TRUE 1.48
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 144 11 Signature R2 0.03 -0.94 1.11 1577.23 1.00 52 135 2 9 TRUE 0.02
pancreatic cancer KRAS_12 CDKN2A Any mutation 117 30 Signature 11 1.31 0.08 2.71 1534.27 1.00 9 88 1 29 TRUE 1.30
pancreatic cancer KRAS_12 CDKN2A Any mutation 110 27 Signature 15 0.49 -0.47 1.48 1346.13 1.00 19 88 5 22 TRUE 0.47
pancreatic cancer KRAS_12 CDKN2A Any mutation 12 11 Signature 17 0.26 -1.05 1.49 1310.71 1.00 33 10 9 2 TRUE 0.16
pancreatic cancer KRAS_12 CDKN2A Any mutation 205 67 Signature 1A 1.10 0.35 1.94 1470.62 1.00 44 145 7 60 TRUE 2.16
pancreatic cancer KRAS_12 CDKN2A Any mutation 82 23 Signature 3 1.88 0.66 3.39 1373.65 1.00 20 59 0 23 TRUE 2.06
pancreatic cancer KRAS_12 CDKN2A Any mutation 62 25 Signature 4 2.07 0.77 3.61 1517.11 1.00 12 37 0 25 TRUE 2.46
pancreatic cancer KRAS_12 CDKN2A Any mutation 54 26 Signature 6 2.43 1.26 4.04 1549.87 1.00 20 28 0 26 TRUE 3.23
pancreatic cancer KRAS_12 CDKN2A Any mutation 49 11 Signature 8 1.37 -0.10 2.93 1625.28 1.00 3 38 0 11 TRUE 1.12
non-small cell lung cancer KRAS_12 CDKN2A Any mutation 584 184 Signature overall -0.36 -1.23 0.39 1425.01 1.00 1252 541 141 43 TRUE 0.42
pancreatic cancer KRAS_12 CDKN2A Any mutation 691 220 Signature overall 1.36 0.44 2.32 1551.47 1.00 160 493 22 198 TRUE 2.33
non-small cell lung cancer KRAS_12 EPHB1 Any mutation 79 17 Signature 2 -0.36 -1.37 0.68 1622.45 1.00 233 75 13 4 FALSE 0.31
non-small cell lung cancer KRAS_12 EPHB1 Any mutation 232 79 Signature 4 -0.67 -1.26 -0.11 1453.28 1.00 419 216 63 16 FALSE 1.65
non-small cell lung cancer KRAS_12 EPHB1 Any mutation 311 96 Signature overall -0.53 -1.87 0.80 1549.78 1.00 652 291 76 20 FALSE 0.36
uterine cancer KRAS_12 PPP2R1A Any mutation 19 20 Signature 15 -1.16 -2.57 -0.01 1439.91 1.00 72 18 19 1 FALSE 1.15
uterine cancer KRAS_12 PPP2R1A Any mutation 34 25 Signature 1A -1.00 -2.14 0.07 1313.43 1.00 164 32 23 2 FALSE 1.08
uterine cancer KRAS_12 PPP2R1A Any mutation 10 14 Signature 3 -0.83 -2.08 0.37 1500.90 1.00 23 8 12 2 FALSE 0.74
uterine cancer KRAS_12 PPP2R1A Any mutation 13 17 Signature 6 -0.77 -2.06 0.47 1490.40 1.00 74 11 15 2 FALSE 0.65
uterine cancer KRAS_12 PPP2R1A Any mutation 77 96 Signature overall -0.99 -2.07 0.03 1482.81 1.00 365 70 89 7 FALSE 1.25
colorectal cancer KRAS_12 ERBB3 Any mutation 99 18 Signature 15 -0.43 -1.28 0.35 1505.23 1.00 271 96 15 3 TRUE 0.54
colorectal cancer KRAS_12 ERBB3 Any mutation 271 46 Signature 1A -0.38 -0.95 0.19 1512.84 1.00 547 260 35 11 TRUE 0.71
colorectal cancer KRAS_12 ERBB3 Any mutation 69 34 Signature 6 -0.12 -0.77 0.60 1417.49 1.00 221 61 26 8 TRUE 0.13
colorectal cancer KRAS_12 ERBB3 Any mutation 439 98 Signature overall -0.31 -1.03 0.39 1482.42 1.00 1039 417 76 22 TRUE 0.38
colorectal cancer KRAS_12 SMAD4 Any mutation 8 17 Signature 10 0.12 -0.67 0.89 1467.67 1.00 17 5 14 3 TRUE 0.12
colorectal cancer KRAS_12 SMAD4 Any mutation 100 60 Signature 15 0.29 -0.22 0.79 1279.29 1.00 250 80 40 20 TRUE 0.62
colorectal cancer KRAS_12 SMAD4 Any mutation 7 11 Signature 17 -0.01 -0.90 0.76 1253.76 1.00 29 6 10 1 TRUE 0.01
colorectal cancer KRAS_12 SMAD4 Any mutation 19 12 Signature 19 0.35 -0.40 1.11 1581.18 1.00 21 13 6 6 TRUE 0.45
colorectal cancer KRAS_12 SMAD4 Any mutation 276 122 Signature 1A 0.10 -0.24 0.46 1539.82 1.00 499 234 80 42 TRUE 0.25
colorectal cancer KRAS_12 SMAD4 Any mutation 35 11 Signature 2 0.00 -0.75 0.68 1492.77 1.00 40 31 7 4 TRUE 0.00
colorectal cancer KRAS_12 SMAD4 Any mutation 70 57 Signature 6 0.06 -0.50 0.61 1418.46 1.00 205 57 44 13 TRUE 0.08
colorectal cancer KRAS_12 SMAD4 Any mutation 14 11 Signature 7 0.46 -0.25 1.29 1571.90 1.00 21 8 5 6 TRUE 0.64
non-small cell lung cancer KRAS_12 SMAD4 Any mutation 44 17 Signature 1A -0.20 -1.42 0.80 1575.37 1.00 209 42 15 2 TRUE 0.14
non-small cell lung cancer KRAS_12 SMAD4 Any mutation 79 21 Signature 2 0.78 -0.07 1.72 1312.98 1.00 234 69 11 10 TRUE 1.05
non-small cell lung cancer KRAS_12 SMAD4 Any mutation 230 16 Signature 4 -0.49 -1.58 0.43 1374.04 1.00 459 227 13 3 TRUE 0.48
pancreatic cancer KRAS_12 SMAD4 Any mutation 115 25 Signature 11 0.29 -0.66 1.30 1257.76 1.00 9 91 1 24 TRUE 0.25
pancreatic cancer KRAS_12 SMAD4 Any mutation 109 31 Signature 15 0.33 -0.50 1.20 1245.61 1.00 20 82 4 27 TRUE 0.35
pancreatic cancer KRAS_12 SMAD4 Any mutation 12 12 Signature 17 -0.98 -2.46 0.19 1431.13 1.00 31 12 12 0 TRUE 0.81
pancreatic cancer KRAS_12 SMAD4 Any mutation 201 56 Signature 1A -0.02 -0.62 0.62 1574.89 1.00 40 157 12 44 TRUE 0.02
pancreatic cancer KRAS_12 SMAD4 Any mutation 33 12 Signature 2 -0.29 -1.38 0.68 1404.03 1.00 8 26 5 7 TRUE 0.24
pancreatic cancer KRAS_12 SMAD4 Any mutation 79 24 Signature 3 0.44 -0.46 1.40 1560.89 1.00 17 58 3 21 TRUE 0.45
pancreatic cancer KRAS_12 SMAD4 Any mutation 61 15 Signature 4 0.38 -0.57 1.46 1382.68 1.00 11 47 1 14 TRUE 0.34
pancreatic cancer KRAS_12 SMAD4 Any mutation 54 15 Signature 6 -0.17 -1.05 0.78 1504.09 1.00 15 44 5 10 TRUE 0.14
pancreatic cancer KRAS_12 SMAD4 Any mutation 50 15 Signature 8 0.57 -0.49 1.73 1373.81 1.00 3 35 0 15 TRUE 0.51
colorectal cancer KRAS_12 SMAD4 Any mutation 529 301 Signature overall 0.17 -0.27 0.64 1150.23 1.00 1082 434 206 95 TRUE 0.34
non-small cell lung cancer KRAS_12 SMAD4 Any mutation 353 54 Signature overall 0.02 -1.12 1.13 1349.18 1.00 902 338 39 15 TRUE 0.01
pancreatic cancer KRAS_12 SMAD4 Any mutation 714 205 Signature overall 0.06 -0.61 0.72 1491.54 1.00 154 552 43 162 TRUE 0.06
colorectal cancer KRAS_12 ATM Any mutation 10 39 Signature 10 -0.91 -2.18 0.28 1403.50 1.00 16 6 35 4 TRUE 0.87
colorectal cancer KRAS_12 ATM Any mutation 100 32 Signature 15 -0.56 -1.49 0.30 1421.45 1.00 264 94 26 6 TRUE 0.69
colorectal cancer KRAS_12 ATM Any mutation 273 77 Signature 1A 0.02 -0.48 0.51 1588.31 1.00 531 247 51 26 TRUE 0.02
colorectal cancer KRAS_12 ATM Any mutation 70 48 Signature 6 -0.97 -1.90 -0.16 1431.69 1.00 207 65 43 5 TRUE 1.47
non-small cell lung cancer KRAS_12 ATM Any mutation 13 12 Signature 13 0.76 -0.32 1.80 1527.38 1.00 76 10 9 3 TRUE 0.79
non-small cell lung cancer KRAS_12 ATM Any mutation 57 11 Signature 18 0.69 -0.24 1.61 1434.35 1.00 89 51 5 6 TRUE 0.82
non-small cell lung cancer KRAS_12 ATM Any mutation 81 27 Signature 2 0.90 0.18 1.63 1410.58 1.00 231 69 15 12 TRUE 1.89
non-small cell lung cancer KRAS_12 ATM Any mutation 50 13 Signature 3 0.58 -0.36 1.55 1441.22 1.00 184 46 9 4 TRUE 0.65
non-small cell lung cancer KRAS_12 ATM Any mutation 241 95 Signature 4 0.75 0.31 1.18 1469.83 1.00 429 195 49 46 TRUE 3.16
non-small cell lung cancer KRAS_12 ATM Any mutation 145 25 Signature R2 0.50 -0.28 1.33 1600.46 1.00 48 126 6 19 TRUE 0.64
non-small cell lung cancer KRAS_12 ATM Any mutation 11 12 Signature U2 1.57 0.59 2.64 1364.93 1.00 31 4 5 7 TRUE 2.44
uterine cancer KRAS_12 ATM Any mutation 34 23 Signature 1A -0.46 -1.85 0.72 1474.04 1.00 169 31 20 3 TRUE 0.32
uterine cancer KRAS_12 ATM Any mutation 14 24 Signature 6 -0.81 -2.44 0.55 1443.09 1.00 70 12 22 2 TRUE 0.54
colorectal cancer KRAS_12 ATM Any mutation 453 196 Signature overall -0.61 -1.77 0.52 1230.68 1.00 1018 412 155 41 TRUE 0.53
non-small cell lung cancer KRAS_12 ATM Any mutation 598 195 Signature overall 0.80 0.12 1.48 1546.04 1.00 1088 501 98 97 TRUE 1.64
uterine cancer KRAS_12 ATM Any mutation 54 121 Signature overall -0.80 -2.56 0.89 1476.30 1.00 263 46 113 8 TRUE 0.45
non-small cell lung cancer KRAS_12 RB1 Any mutation 13 11 Signature 13 -0.79 -1.75 0.15 1459.69 1.00 78 11 9 2 TRUE 0.97
non-small cell lung cancer KRAS_12 RB1 Any mutation 57 11 Signature 18 -0.87 -1.74 0.01 1481.36 1.00 85 54 8 3 TRUE 1.29
non-small cell lung cancer KRAS_12 RB1 Any mutation 44 16 Signature 1A -0.92 -1.86 0.02 1439.84 1.00 208 42 14 2 TRUE 1.30
non-small cell lung cancer KRAS_12 RB1 Any mutation 79 28 Signature 2 -1.00 -1.86 -0.26 1480.84 1.00 220 76 25 3 TRUE 1.83
non-small cell lung cancer KRAS_12 RB1 Any mutation 50 18 Signature 3 -1.22 -2.28 -0.34 1699.84 1.00 175 50 18 0 TRUE 1.90
non-small cell lung cancer KRAS_12 RB1 Any mutation 230 67 Signature 4 -1.03 -1.65 -0.48 1526.36 1.00 419 220 57 10 TRUE 3.25
non-small cell lung cancer KRAS_12 RB1 Any mutation 473 151 Signature overall -0.97 -1.62 -0.36 1406.94 1.00 1185 453 131 20 TRUE 2.47
cancer of unknown primary KRAS_12 KMT2D Any mutation 30 18 Signature 1A -1.43 -2.89 -0.17 1400.51 1.00 72 28 16 2 FALSE 1.42
cancer of unknown primary KRAS_12 KMT2D Any mutation 18 15 Signature 4 -1.21 -2.76 0.10 1502.49 1.00 51 16 13 2 FALSE 1.04
colorectal cancer KRAS_12 KMT2D Any mutation 8 19 Signature 10 -1.25 -2.58 -0.16 1496.77 1.00 16 7 18 1 FALSE 1.36
colorectal cancer KRAS_12 KMT2D Any mutation 100 55 Signature 15 -0.86 -1.60 -0.22 1490.38 1.00 261 92 47 8 FALSE 1.87
colorectal cancer KRAS_12 KMT2D Any mutation 278 128 Signature 1A -0.73 -1.17 -0.29 1429.68 1.00 512 252 102 26 FALSE 2.89
colorectal cancer KRAS_12 KMT2D Any mutation 76 142 Signature 6 -1.00 -1.56 -0.47 1615.80 1.00 171 60 126 16 FALSE 3.46
non-small cell lung cancer KRAS_12 KMT2D Any mutation 13 16 Signature 13 -1.26 -2.82 0.01 1445.90 1.00 70 13 16 0 FALSE 1.05
non-small cell lung cancer KRAS_12 KMT2D Any mutation 57 16 Signature 18 -0.91 -1.98 0.06 1521.64 1.00 82 54 13 3 FALSE 1.06
non-small cell lung cancer KRAS_12 KMT2D Any mutation 44 22 Signature 1A -0.80 -1.98 0.14 1569.86 1.00 205 42 20 2 FALSE 0.81
non-small cell lung cancer KRAS_12 KMT2D Any mutation 80 46 Signature 2 -0.19 -0.85 0.47 1480.71 1.00 216 69 35 11 FALSE 0.24
non-small cell lung cancer KRAS_12 KMT2D Any mutation 50 13 Signature 3 -1.01 -2.26 0.12 1449.96 1.00 181 49 12 1 FALSE 0.96
non-small cell lung cancer KRAS_12 KMT2D Any mutation 232 129 Signature 4 -0.69 -1.13 -0.26 1465.05 1.00 391 205 102 27 FALSE 2.68
non-small cell lung cancer KRAS_12 KMT2D Any mutation 144 13 Signature R2 -0.23 -1.14 0.76 1457.84 1.00 51 134 3 10 FALSE 0.20
uterine cancer KRAS_12 KMT2D Any mutation 20 27 Signature 15 -0.06 -1.05 0.85 1287.29 1.00 73 14 21 6 FALSE 0.05
uterine cancer KRAS_12 KMT2D Any mutation 34 61 Signature 1A -0.68 -1.52 0.14 1590.79 1.00 142 28 55 6 FALSE 0.93
uterine cancer KRAS_12 KMT2D Any mutation 7 13 Signature 20 -0.87 -2.28 0.39 1553.97 1.00 24 6 12 1 FALSE 0.71
uterine cancer KRAS_12 KMT2D Any mutation 14 63 Signature 6 -0.75 -1.70 0.17 1538.37 1.00 45 9 58 5 FALSE 0.95
cancer of unknown primary KRAS_12 KMT2D Any mutation 56 76 Signature overall -1.48 -2.94 -0.15 1465.47 1.00 168 51 71 5 FALSE 1.43
colorectal cancer KRAS_12 KMT2D Any mutation 462 344 Signature overall -0.94 -1.74 -0.18 1539.30 1.00 960 411 293 51 FALSE 1.73
non-small cell lung cancer KRAS_12 KMT2D Any mutation 620 255 Signature overall -0.73 -1.50 -0.04 1463.82 1.00 1196 566 201 54 FALSE 1.29
uterine cancer KRAS_12 KMT2D Any mutation 81 233 Signature overall -0.67 -1.61 0.21 1420.48 1.00 313 60 212 21 FALSE 0.87
colorectal cancer KRAS_12 TSC2 Any mutation 99 11 Signature 15 0.30 -0.85 1.56 1364.00 1.00 280 94 6 5 TRUE 0.20
colorectal cancer KRAS_12 TSC2 Any mutation 272 36 Signature 1A -0.26 -0.97 0.45 1251.56 1.00 554 262 26 10 TRUE 0.33
colorectal cancer KRAS_12 TSC2 Any mutation 69 44 Signature 6 -1.14 -2.20 -0.22 1356.70 1.00 210 66 41 3 TRUE 1.56
colorectal cancer KRAS_12 TSC2 Any mutation 440 91 Signature overall -0.37 -1.59 0.89 1520.57 1.00 1044 422 73 18 TRUE 0.25
colorectal cancer KRAS_12 APC Any mutation 16 94 Signature 10 -0.12 -0.83 0.63 1569.56 1.00 3 0 78 16 TRUE 0.13
colorectal cancer KRAS_12 APC Any mutation 27 39 Signature 11 -0.04 -0.77 0.66 1474.84 1.00 1 9 21 18 TRUE 0.04
colorectal cancer KRAS_12 APC Any mutation 10 25 Signature 14 0.20 -0.51 0.94 1604.19 1.00 2 1 16 9 TRUE 0.23
colorectal cancer KRAS_12 APC Any mutation 154 469 Signature 15 0.32 -0.09 0.78 1474.74 1.00 67 16 331 138 TRUE 0.79
colorectal cancer KRAS_12 APC Any mutation 10 46 Signature 17 -0.38 -1.18 0.27 1558.30 1.00 11 4 40 6 TRUE 0.52
colorectal cancer KRAS_12 APC Any mutation 22 63 Signature 18 -0.15 -0.88 0.50 1455.28 1.00 3 5 46 17 TRUE 0.18
colorectal cancer KRAS_12 APC Any mutation 23 38 Signature 19 -0.10 -0.75 0.52 1494.17 1.00 9 9 24 14 TRUE 0.12
colorectal cancer KRAS_12 APC Any mutation 392 962 Signature 1A 0.05 -0.24 0.33 1492.34 1.00 149 72 642 320 TRUE 0.13
colorectal cancer KRAS_12 APC Any mutation 12 22 Signature 1B 0.37 -0.38 1.10 1295.53 1.00 7 1 11 11 TRUE 0.49
colorectal cancer KRAS_12 APC Any mutation 50 95 Signature 2 0.36 -0.24 0.94 1394.27 1.00 11 6 51 44 TRUE 0.63
colorectal cancer KRAS_12 APC Any mutation 13 34 Signature 20 -0.03 -0.72 0.66 1500.44 1.00 5 3 24 10 TRUE 0.03
colorectal cancer KRAS_12 APC Any mutation 11 25 Signature 21 0.38 -0.29 1.17 1383.19 1.00 10 0 14 11 TRUE 0.50
colorectal cancer KRAS_12 APC Any mutation 19 42 Signature 3 0.19 -0.49 0.87 1387.95 1.00 8 3 26 16 TRUE 0.23
colorectal cancer KRAS_12 APC Any mutation 22 49 Signature 4 0.03 -0.64 0.68 1512.76 1.00 6 5 32 17 TRUE 0.03
colorectal cancer KRAS_12 APC Any mutation 104 355 Signature 6 0.20 -0.28 0.65 1531.24 1.00 79 16 267 88 TRUE 0.42
colorectal cancer KRAS_12 APC Any mutation 20 40 Signature 7 0.27 -0.42 0.98 1542.26 1.00 9 3 23 17 TRUE 0.35
colorectal cancer KRAS_12 APC Any mutation 19 30 Signature 8 0.47 -0.23 1.16 1314.87 1.00 1 2 13 17 TRUE 0.71
colorectal cancer KRAS_12 APC Any mutation 20 20 Signature R2 0.32 -0.42 1.01 1316.72 1.00 3 6 6 14 TRUE 0.41
colorectal cancer KRAS_12 APC Any mutation 10 14 Signature U1 0.03 -0.76 0.79 1652.24 1.00 2 4 8 6 TRUE 0.03
non-small cell lung cancer KRAS_12 APC Any mutation 44 13 Signature 1A -0.41 -1.45 0.59 1442.46 1.00 211 42 11 2 TRUE 0.37
non-small cell lung cancer KRAS_12 APC Any mutation 82 23 Signature 2 -0.10 -0.96 0.73 1442.39 1.00 229 75 16 7 TRUE 0.09
non-small cell lung cancer KRAS_12 APC Any mutation 230 50 Signature 4 -0.75 -1.50 -0.11 1489.91 1.00 434 222 42 8 TRUE 1.43
uterine cancer KRAS_12 APC Any mutation 34 18 Signature 1A -0.47 -2.15 0.82 1451.53 1.00 174 32 16 2 TRUE 0.27
uterine cancer KRAS_12 APC Any mutation 13 15 Signature 6 -0.11 -1.81 1.43 1514.91 1.00 76 11 13 2 TRUE 0.05
colorectal cancer KRAS_12 APC Any mutation 954 2462 Signature overall 0.13 -0.21 0.46 1334.12 1.00 386 165 1673 789 TRUE 0.34
non-small cell lung cancer KRAS_12 APC Any mutation 356 86 Signature overall -0.41 -1.29 0.52 1545.09 1.00 874 339 69 17 TRUE 0.42
uterine cancer KRAS_12 APC Any mutation 51 96 Signature overall 0.06 -2.11 2.36 1497.11 1.00 267 43 88 8 TRUE 0.02
colorectal cancer KRAS_12 ERBB2 Any mutation 270 47 Signature 1A -0.88 -1.61 -0.18 1580.04 1.00 541 262 39 8 TRUE 1.77
colorectal cancer KRAS_12 ERBB2 Any mutation 69 29 Signature 6 -0.76 -1.74 0.14 1343.29 1.00 221 65 25 4 TRUE 0.97
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 44 15 Signature 1A -1.75 -3.48 -0.33 1483.79 1.00 208 43 14 1 TRUE 1.56
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 79 12 Signature 2 -2.06 -4.03 -0.69 1327.56 1.00 233 79 12 0 TRUE 1.83
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 230 19 Signature 4 -1.81 -3.33 -0.65 1362.99 1.00 457 228 17 2 TRUE 2.09
colorectal cancer KRAS_12 ERBB2 Any mutation 339 76 Signature overall -0.82 -2.05 0.27 1314.86 1.00 762 327 64 12 TRUE 0.82
non-small cell lung cancer KRAS_12 ERBB2 Any mutation 353 46 Signature overall -1.86 -3.46 -0.59 1374.23 1.00 898 350 43 3 TRUE 1.96
uterine cancer KRAS_12 JAK1 Any mutation 20 14 Signature 15 0.55 -0.59 1.61 1569.03 1.00 83 16 10 4 TRUE 0.49
uterine cancer KRAS_12 JAK1 Any mutation 36 35 Signature 1A 0.48 -0.38 1.28 1482.29 1.00 161 28 27 8 TRUE 0.58
uterine cancer KRAS_12 JAK1 Any mutation 14 42 Signature 6 0.30 -0.73 1.28 1555.26 1.00 59 8 36 6 TRUE 0.25
uterine cancer KRAS_12 JAK1 Any mutation 72 117 Signature overall 0.45 -0.60 1.59 1493.84 1.00 327 52 97 20 TRUE 0.37
colorectal cancer KRAS_12 ARID2 Any mutation 8 16 Signature 10 -0.62 -2.00 0.66 1599.32 1.00 17 6 14 2 FALSE 0.44
colorectal cancer KRAS_12 ARID2 Any mutation 99 19 Signature 15 -0.69 -1.79 0.28 1608.84 1.00 273 96 16 3 FALSE 0.72
colorectal cancer KRAS_12 ARID2 Any mutation 271 42 Signature 1A -0.07 -0.71 0.55 1388.80 1.00 551 257 28 14 FALSE 0.09
colorectal cancer KRAS_12 ARID2 Any mutation 69 27 Signature 6 -0.79 -1.89 0.17 1492.79 1.00 220 66 24 3 FALSE 0.88
non-small cell lung cancer KRAS_12 ARID2 Any mutation 57 11 Signature 18 0.00 -0.78 0.87 1474.07 1.00 88 51 5 6 FALSE 0.00
non-small cell lung cancer KRAS_12 ARID2 Any mutation 79 18 Signature 2 -0.19 -0.93 0.52 1513.65 1.00 233 74 13 5 FALSE 0.21
non-small cell lung cancer KRAS_12 ARID2 Any mutation 50 16 Signature 3 -0.51 -1.51 0.25 1442.66 1.00 178 49 15 1 FALSE 0.60
non-small cell lung cancer KRAS_12 ARID2 Any mutation 231 67 Signature 4 -0.41 -0.97 0.10 1452.37 1.00 428 216 52 15 FALSE 0.87
colorectal cancer KRAS_12 ARID2 Any mutation 447 104 Signature overall -0.54 -1.64 0.56 1501.21 1.00 1061 425 82 22 FALSE 0.48
non-small cell lung cancer KRAS_12 ARID2 Any mutation 417 112 Signature overall -0.28 -0.94 0.36 1412.99 1.00 927 390 85 27 FALSE 0.40
colorectal cancer KRAS_12 MTOR Any mutation 8 12 Signature 10 -1.30 -3.29 0.09 1519.51 1.00 19 8 12 0 TRUE 0.90
colorectal cancer KRAS_12 MTOR Any mutation 99 17 Signature 15 -0.47 -1.51 0.50 1564.61 1.00 275 95 13 4 TRUE 0.44
colorectal cancer KRAS_12 MTOR Any mutation 273 48 Signature 1A -0.39 -1.05 0.24 1359.64 1.00 543 260 35 13 TRUE 0.66
colorectal cancer KRAS_12 MTOR Any mutation 69 45 Signature 6 -0.88 -1.84 -0.07 1455.85 1.00 211 64 40 5 TRUE 1.29
non-small cell lung cancer KRAS_12 MTOR Any mutation 230 41 Signature 4 0.18 -0.47 0.83 586.81 1.00 446 215 26 15 TRUE 0.24
colorectal cancer KRAS_12 MTOR Any mutation 449 122 Signature overall -0.74 -1.82 0.25 1596.42 1.00 1048 427 100 22 TRUE 0.79
non-small cell lung cancer KRAS_12 MTOR Any mutation 230 41 Signature overall 0.08 -4.31 4.00 1693.59 1.00 446 215 26 15 TRUE 0.02
colorectal cancer KRAS_12 NOTCH1 Any mutation 8 11 Signature 10 -1.47 -3.51 0.10 1480.18 1.00 20 8 11 0 TRUE 0.98
colorectal cancer KRAS_12 NOTCH1 Any mutation 101 17 Signature 15 -0.46 -1.61 0.48 1416.06 1.00 277 97 13 4 TRUE 0.42
colorectal cancer KRAS_12 NOTCH1 Any mutation 272 47 Signature 1A -0.36 -1.05 0.27 1245.11 1.00 546 259 34 13 TRUE 0.56
colorectal cancer KRAS_12 NOTCH1 Any mutation 71 82 Signature 6 -0.94 -1.71 -0.25 1436.45 1.00 190 62 73 9 TRUE 1.92
non-small cell lung cancer KRAS_12 NOTCH1 Any mutation 79 12 Signature 2 -0.98 -2.36 0.30 1374.70 1.00 235 77 10 2 TRUE 0.87
non-small cell lung cancer KRAS_12 NOTCH1 Any mutation 230 54 Signature 4 -1.22 -2.03 -0.51 1455.62 1.00 428 223 47 7 TRUE 2.61
colorectal cancer KRAS_12 NOTCH1 Any mutation 452 157 Signature overall -0.79 -2.00 0.22 1414.31 1.00 1033 426 131 26 TRUE 0.81
non-small cell lung cancer KRAS_12 NOTCH1 Any mutation 309 66 Signature overall -1.08 -2.52 0.53 1449.87 1.00 663 300 57 9 TRUE 0.86
colorectal cancer KRAS_12 SETD2 Any mutation 9 22 Signature 10 -1.44 -2.93 -0.10 1517.05 1.00 17 7 20 2 FALSE 1.33
colorectal cancer KRAS_12 SETD2 Any mutation 99 13 Signature 15 -1.61 -3.32 -0.18 1528.89 1.00 276 98 12 1 FALSE 1.36
colorectal cancer KRAS_12 SETD2 Any mutation 270 31 Signature 1A -1.35 -2.40 -0.44 1488.82 1.00 550 266 27 4 FALSE 2.20
colorectal cancer KRAS_12 SETD2 Any mutation 70 39 Signature 6 -1.45 -2.65 -0.48 1482.25 1.00 211 67 36 3 FALSE 2.07
non-small cell lung cancer KRAS_12 SETD2 Any mutation 14 16 Signature 13 0.10 -1.08 1.25 1576.23 1.00 74 11 13 3 FALSE 0.06
non-small cell lung cancer KRAS_12 SETD2 Any mutation 81 44 Signature 2 0.02 -0.72 0.70 1559.21 1.00 223 70 33 11 FALSE 0.02
non-small cell lung cancer KRAS_12 SETD2 Any mutation 51 15 Signature 3 -0.16 -1.25 0.86 1398.97 1.00 182 48 12 3 FALSE 0.12
non-small cell lung cancer KRAS_12 SETD2 Any mutation 232 55 Signature 4 -0.27 -0.88 0.27 1545.08 1.00 435 217 40 15 FALSE 0.44
non-small cell lung cancer KRAS_12 SETD2 Any mutation 146 14 Signature R2 -0.10 -1.01 0.81 1491.63 1.00 50 136 4 10 FALSE 0.09
colorectal cancer KRAS_12 SETD2 Any mutation 448 105 Signature overall -1.44 -2.73 -0.12 1712.81 1.00 1054 438 95 10 FALSE 1.58
non-small cell lung cancer KRAS_12 SETD2 Any mutation 524 144 Signature overall -0.09 -0.97 0.82 1428.10 1.00 964 482 102 42 FALSE 0.08
non-small cell lung cancer KRAS_12 PBRM1 Any mutation 79 20 Signature 2 -0.20 -1.11 0.72 1518.37 1.00 235 74 15 5 TRUE 0.18
non-small cell lung cancer KRAS_12 PBRM1 Any mutation 230 27 Signature 4 -0.48 -1.34 0.29 1383.10 1.00 452 224 21 6 TRUE 0.62
non-small cell lung cancer KRAS_12 PBRM1 Any mutation 309 47 Signature overall -0.35 -1.54 0.89 1462.58 1.00 687 298 36 11 TRUE 0.25
colorectal cancer KRAS_12 EPHA3 Any mutation 8 14 Signature 10 -0.94 -2.58 0.36 1483.88 1.00 21 7 13 1 FALSE 0.65
colorectal cancer KRAS_12 EPHA3 Any mutation 99 13 Signature 15 -0.80 -2.06 0.24 1587.44 1.00 275 97 11 2 FALSE 0.76
colorectal cancer KRAS_12 EPHA3 Any mutation 271 42 Signature 1A -0.20 -0.81 0.45 1464.12 1.00 547 258 29 13 FALSE 0.27
colorectal cancer KRAS_12 EPHA3 Any mutation 69 26 Signature 6 -0.84 -1.98 0.11 1364.93 1.00 221 66 23 3 FALSE 0.93
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 57 13 Signature 18 -0.25 -1.25 0.70 1444.15 1.00 85 53 9 4 FALSE 0.20
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 81 27 Signature 2 0.12 -0.63 0.87 1488.45 1.00 227 73 19 8 FALSE 0.12
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 51 18 Signature 3 0.52 -0.42 1.46 1579.31 1.00 183 44 11 7 FALSE 0.59
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 233 112 Signature 4 -0.34 -0.80 0.07 1480.34 1.00 397 204 83 29 FALSE 0.96
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 145 13 Signature R2 -0.33 -1.22 0.56 1271.74 1.00 49 137 5 8 FALSE 0.33
colorectal cancer KRAS_12 EPHA3 Any mutation 447 95 Signature overall -0.69 -1.83 0.34 1453.47 1.00 1064 428 76 19 FALSE 0.67
non-small cell lung cancer KRAS_12 EPHA3 Any mutation 567 183 Signature overall -0.05 -0.83 0.79 1393.72 1.00 941 511 127 56 FALSE 0.05
non-small cell lung cancer KRAS_12 KDR Any mutation 79 12 Signature 2 0.53 -0.55 1.61 1430.27 1.00 238 74 7 5 TRUE 0.46
non-small cell lung cancer KRAS_12 KDR Any mutation 51 11 Signature 3 1.05 -0.10 2.34 1098.47 1.00 188 45 5 6 TRUE 1.04
non-small cell lung cancer KRAS_12 KDR Any mutation 231 76 Signature 4 -0.79 -1.44 -0.21 1462.14 1.00 414 218 63 13 TRUE 1.86
non-small cell lung cancer KRAS_12 KDR Any mutation 361 99 Signature overall 0.25 -1.09 1.76 1500.37 1.00 840 337 75 24 TRUE 0.14
colorectal cancer KRAS_12 PTCH1 Any mutation 8 11 Signature 10 -1.10 -2.62 0.24 1437.41 1.00 20 7 10 1 TRUE 0.92
colorectal cancer KRAS_12 PTCH1 Any mutation 99 14 Signature 15 -1.03 -2.19 0.02 1483.13 1.00 277 97 12 2 TRUE 1.17
colorectal cancer KRAS_12 PTCH1 Any mutation 270 55 Signature 1A -0.89 -1.60 -0.25 1320.31 1.00 539 260 45 10 TRUE 2.03
colorectal cancer KRAS_12 PTCH1 Any mutation 70 53 Signature 6 -1.25 -2.19 -0.45 1571.14 1.00 210 66 49 4 TRUE 2.25
colorectal cancer KRAS_12 PTCH1 Any mutation 447 133 Signature overall -1.05 -2.01 -0.14 1513.35 1.00 1046 430 116 17 TRUE 1.48
colorectal cancer KRAS_12 TET1 Any mutation 8 27 Signature 10 -2.11 -4.19 -0.46 1461.82 1.00 16 7 26 1 FALSE 1.60
colorectal cancer KRAS_12 TET1 Any mutation 95 18 Signature 15 -2.63 -5.62 -0.75 1316.56 1.00 268 95 18 0 FALSE 1.48
colorectal cancer KRAS_12 TET1 Any mutation 261 25 Signature 1A -0.62 -1.63 0.25 1565.54 1.00 543 255 19 6 FALSE 0.71
colorectal cancer KRAS_12 TET1 Any mutation 66 28 Signature 6 -0.80 -1.92 0.22 1261.59 1.00 216 62 24 4 FALSE 0.81
non-small cell lung cancer KRAS_12 TET1 Any mutation 79 12 Signature 2 1.09 -0.15 2.35 1431.53 1.00 238 72 5 7 FALSE 1.07
non-small cell lung cancer KRAS_12 TET1 Any mutation 232 60 Signature 4 -0.42 -1.05 0.16 1492.14 1.00 432 218 46 14 FALSE 0.75
colorectal cancer KRAS_12 TET1 Any mutation 430 98 Signature overall -1.50 -3.19 -0.04 1513.12 1.00 1043 419 87 11 FALSE 1.19
non-small cell lung cancer KRAS_12 TET1 Any mutation 311 72 Signature overall 0.29 -1.88 2.52 1465.82 1.00 670 290 51 21 FALSE 0.10
uterine cancer KRAS_12 FGFR2 Any mutation 34 26 Signature 1A -2.52 -5.33 -0.70 538.13 1.00 163 33 25 1 TRUE 1.38
uterine cancer KRAS_12 FGFR2 Any mutation 13 22 Signature 6 -2.92 -6.36 -0.72 647.60 1.00 66 13 22 0 TRUE 1.39
uterine cancer KRAS_12 FGFR2 Any mutation 47 48 Signature overall -2.67 -5.76 -0.46 574.81 1.00 229 46 47 1 TRUE 1.30
non-small cell lung cancer KRAS_12 TBX3 Any mutation 230 75 Signature 4 -1.01 -1.67 -0.43 1489.50 1.00 417 218 63 12 FALSE 2.85
non-small cell lung cancer KRAS_12 TBX3 Any mutation 144 15 Signature R2 -0.40 -1.36 0.62 1250.64 1.00 50 134 5 10 FALSE 0.36
non-small cell lung cancer KRAS_12 TBX3 Any mutation 374 90 Signature overall -0.69 -2.61 1.32 1372.46 1.00 467 352 68 22 FALSE 0.34
colorectal cancer KRAS_12 SMAD3 Any mutation 102 21 Signature 15 0.33 -0.29 0.94 1339.56 1.00 273 95 14 7 TRUE 0.56
colorectal cancer KRAS_12 SMAD3 Any mutation 274 38 Signature 1A 0.31 -0.21 0.83 1577.61 1.00 553 259 23 15 TRUE 0.61
colorectal cancer KRAS_12 SMAD3 Any mutation 70 20 Signature 6 0.35 -0.31 0.96 1450.65 1.00 228 64 14 6 TRUE 0.57
colorectal cancer KRAS_12 SMAD3 Any mutation 446 79 Signature overall 0.33 -0.19 0.91 1355.17 1.00 1054 418 51 28 TRUE 0.63
non-small cell lung cancer KRAS_12 NTRK3 Any mutation 80 15 Signature 2 0.82 -0.13 1.74 1440.57 1.00 238 73 8 7 FALSE 1.02
non-small cell lung cancer KRAS_12 NTRK3 Any mutation 50 14 Signature 3 0.66 -0.42 1.66 1482.90 1.00 185 45 9 5 FALSE 0.66
non-small cell lung cancer KRAS_12 NTRK3 Any mutation 234 105 Signature 4 -0.37 -0.81 0.04 1469.26 1.00 410 208 79 26 FALSE 1.01
non-small cell lung cancer KRAS_12 NTRK3 Any mutation 145 18 Signature R2 0.90 -0.10 1.98 1402.25 1.00 52 129 2 16 FALSE 1.00
non-small cell lung cancer KRAS_12 NTRK3 Any mutation 509 152 Signature overall 0.50 -0.63 1.69 1498.02 1.00 885 455 98 54 FALSE 0.40
colorectal cancer KRAS_12 GRIN2A Any mutation 8 18 Signature 10 -1.26 -2.88 0.09 1637.48 1.00 17 7 17 1 FALSE 1.01
colorectal cancer KRAS_12 GRIN2A Any mutation 99 12 Signature 15 -0.41 -1.65 0.76 1476.35 1.00 280 96 9 3 FALSE 0.31
colorectal cancer KRAS_12 GRIN2A Any mutation 271 43 Signature 1A -0.54 -1.27 0.15 1310.09 1.00 542 261 33 10 FALSE 0.88
colorectal cancer KRAS_12 GRIN2A Any mutation 69 43 Signature 6 -0.68 -1.56 0.15 1498.35 1.00 208 63 37 6 FALSE 0.94
non-small cell lung cancer KRAS_12 GRIN2A Any mutation 79 15 Signature 2 -0.51 -1.70 0.58 1325.38 1.00 233 76 12 3 FALSE 0.42
non-small cell lung cancer KRAS_12 GRIN2A Any mutation 232 76 Signature 4 -0.66 -1.23 -0.10 1422.13 1.00 418 216 60 16 FALSE 1.69
non-small cell lung cancer KRAS_12 GRIN2A Any mutation 144 13 Signature R2 -0.75 -1.69 0.20 1487.85 1.00 48 137 6 7 FALSE 0.93
colorectal cancer KRAS_12 GRIN2A Any mutation 447 116 Signature overall -0.69 -1.86 0.49 1450.17 1.00 1047 427 96 20 FALSE 0.61
non-small cell lung cancer KRAS_12 GRIN2A Any mutation 455 104 Signature overall -0.66 -2.05 0.56 1619.09 1.00 699 429 78 26 FALSE 0.52
uterine cancer KRAS_12 CTCF Any mutation 19 18 Signature 15 0.34 -0.68 1.38 1493.02 1.00 78 14 13 5 FALSE 0.30
uterine cancer KRAS_12 CTCF Any mutation 35 49 Signature 1A 0.40 -0.39 1.14 1529.17 1.00 150 24 38 11 FALSE 0.52
uterine cancer KRAS_12 CTCF Any mutation 13 40 Signature 6 -0.40 -1.64 0.56 1589.62 1.00 51 10 37 3 FALSE 0.33
uterine cancer KRAS_12 CTCF Any mutation 68 123 Signature overall -0.03 -1.05 0.91 1464.27 1.00 303 49 104 19 FALSE 0.02
non-small cell lung cancer KRAS_12 STK11 Any mutation 21 11 Signature 11 1.62 0.75 2.65 1482.68 1.00 22 11 1 10 TRUE 3.08
non-small cell lung cancer KRAS_12 STK11 Any mutation 20 19 Signature 15 0.81 -0.07 1.64 1804.38 1.00 102 15 14 5 TRUE 1.20
non-small cell lung cancer KRAS_12 STK11 Any mutation 8 11 Signature 16 0.62 -0.40 1.59 1575.96 1.00 43 6 9 2 TRUE 0.62
non-small cell lung cancer KRAS_12 STK11 Any mutation 58 38 Signature 18 0.48 -0.19 1.11 1481.84 1.00 72 42 22 16 TRUE 0.81
non-small cell lung cancer KRAS_12 STK11 Any mutation 15 17 Signature 19 0.90 0.00 1.72 1478.68 1.00 37 9 11 6 TRUE 1.39
non-small cell lung cancer KRAS_12 STK11 Any mutation 44 21 Signature 1A 1.56 0.78 2.36 1361.93 1.00 213 32 9 12 TRUE 4.20
non-small cell lung cancer KRAS_12 STK11 Any mutation 80 55 Signature 2 0.26 -0.34 0.84 1499.60 1.00 212 66 41 14 TRUE 0.42
non-small cell lung cancer KRAS_12 STK11 Any mutation 13 13 Signature 20 1.28 0.34 2.22 1439.95 1.00 57 7 7 6 TRUE 2.13
non-small cell lung cancer KRAS_12 STK11 Any mutation 50 37 Signature 3 0.76 0.09 1.38 1584.09 1.00 168 38 25 12 TRUE 1.62
non-small cell lung cancer KRAS_12 STK11 Any mutation 231 163 Signature 4 0.37 0.01 0.71 1365.80 1.00 372 169 101 62 TRUE 1.42
non-small cell lung cancer KRAS_12 STK11 Any mutation 27 13 Signature 8 1.00 0.12 1.88 1349.36 1.00 32 19 5 8 TRUE 1.57
non-small cell lung cancer KRAS_12 STK11 Any mutation 145 61 Signature R2 0.76 0.13 1.42 1484.92 1.00 41 97 13 48 TRUE 1.85
non-small cell lung cancer KRAS_12 STK11 Any mutation 17 13 Signature U1 1.25 0.37 2.18 1512.43 1.00 87 11 7 6 TRUE 2.25
non-small cell lung cancer KRAS_12 STK11 Any mutation 729 472 Signature overall 0.89 0.43 1.36 1411.99 1.00 1458 522 265 207 TRUE 3.73
colorectal cancer KRAS_12 ASXL1 Any mutation 8 11 Signature 10 -2.06 -4.71 -0.31 1607.06 1.00 17 8 11 0 TRUE 1.16
colorectal cancer KRAS_12 ASXL1 Any mutation 99 14 Signature 15 -2.15 -4.64 -0.51 1615.55 1.00 274 99 14 0 TRUE 1.40
colorectal cancer KRAS_12 ASXL1 Any mutation 270 31 Signature 1A -0.93 -1.84 -0.11 1478.06 1.00 552 264 25 6 TRUE 1.45
colorectal cancer KRAS_12 ASXL1 Any mutation 69 34 Signature 6 -0.84 -1.83 0.10 1514.32 1.00 218 64 29 5 TRUE 1.04
colorectal cancer KRAS_12 ASXL1 Any mutation 446 90 Signature overall -1.49 -2.96 -0.24 1558.63 1.00 1061 435 79 11 TRUE 1.37
colorectal cancer KRAS_12 EP300 Any mutation 99 18 Signature 15 -1.00 -2.18 0.06 1399.39 1.00 274 97 16 2 TRUE 1.15
colorectal cancer KRAS_12 EP300 Any mutation 270 36 Signature 1A -0.56 -1.30 0.12 1601.11 1.00 550 261 27 9 TRUE 0.89
colorectal cancer KRAS_12 EP300 Any mutation 70 51 Signature 6 -0.96 -1.84 -0.19 1481.32 1.00 210 65 46 5 TRUE 1.63
non-small cell lung cancer KRAS_12 EP300 Any mutation 13 11 Signature 13 -0.11 -1.44 1.27 1379.23 1.00 78 11 9 2 TRUE 0.06
non-small cell lung cancer KRAS_12 EP300 Any mutation 79 20 Signature 2 -1.02 -2.57 0.05 1606.27 1.00 232 78 19 1 TRUE 0.89
non-small cell lung cancer KRAS_12 EP300 Any mutation 231 30 Signature 4 -0.04 -0.78 0.67 1524.64 1.00 453 220 19 11 TRUE 0.04
uterine cancer KRAS_12 EP300 Any mutation 35 21 Signature 1A -0.20 -1.44 0.91 1525.58 1.00 167 32 18 3 TRUE 0.13
uterine cancer KRAS_12 EP300 Any mutation 13 20 Signature 6 0.12 -1.25 1.37 1380.32 1.00 70 10 17 3 TRUE 0.07
colorectal cancer KRAS_12 EP300 Any mutation 439 105 Signature overall -0.84 -1.90 0.12 1353.27 1.00 1034 423 89 16 TRUE 0.98
non-small cell lung cancer KRAS_12 EP300 Any mutation 323 61 Signature overall -0.40 -1.69 0.80 1589.13 1.00 763 309 47 14 TRUE 0.28
uterine cancer KRAS_12 EP300 Any mutation 50 74 Signature overall 0.10 -1.63 2.18 1464.39 1.00 258 42 66 8 TRUE 0.04
colorectal cancer KRAS_12 ERBB4 Any mutation 8 18 Signature 10 -0.94 -2.63 0.36 1614.19 1.00 18 7 17 1 TRUE 0.65
colorectal cancer KRAS_12 ERBB4 Any mutation 100 23 Signature 15 -0.34 -1.31 0.51 1241.54 1.00 270 95 18 5 TRUE 0.33
colorectal cancer KRAS_12 ERBB4 Any mutation 271 43 Signature 1A -0.08 -0.70 0.54 1560.97 1.00 548 257 29 14 TRUE 0.10
colorectal cancer KRAS_12 ERBB4 Any mutation 69 31 Signature 6 -0.10 -0.96 0.69 1595.04 1.00 222 62 24 7 TRUE 0.09
non-small cell lung cancer KRAS_12 ERBB4 Any mutation 44 11 Signature 1A -0.04 -1.35 1.26 1529.59 1.00 214 41 8 3 TRUE 0.02
non-small cell lung cancer KRAS_12 ERBB4 Any mutation 79 17 Signature 2 -0.74 -1.99 0.31 1550.90 1.00 233 77 15 2 TRUE 0.69
non-small cell lung cancer KRAS_12 ERBB4 Any mutation 233 97 Signature 4 -0.51 -1.01 -0.06 1311.60 1.00 413 211 75 22 TRUE 1.46
colorectal cancer KRAS_12 ERBB4 Any mutation 448 115 Signature overall -0.37 -1.50 0.70 1545.00 1.00 1058 421 88 27 TRUE 0.30
non-small cell lung cancer KRAS_12 ERBB4 Any mutation 356 125 Signature overall -0.43 -1.60 0.71 1507.03 1.00 860 329 98 27 TRUE 0.35
colorectal cancer KRAS_12 MED12 Any mutation 99 11 Signature 15 -0.64 -1.96 0.53 1468.05 1.00 278 97 9 2 TRUE 0.52
colorectal cancer KRAS_12 MED12 Any mutation 271 34 Signature 1A -0.05 -0.79 0.67 1573.89 1.00 555 259 22 12 TRUE 0.05
colorectal cancer KRAS_12 MED12 Any mutation 70 42 Signature 6 -1.11 -2.26 -0.18 1445.15 1.00 213 67 39 3 TRUE 1.48
non-small cell lung cancer KRAS_12 MED12 Any mutation 79 25 Signature 2 -0.41 -1.24 0.52 1350.78 1.00 227 73 19 6 TRUE 0.45
non-small cell lung cancer KRAS_12 MED12 Any mutation 231 72 Signature 4 -0.84 -1.47 -0.26 948.69 1.00 421 219 60 12 TRUE 2.18
uterine cancer KRAS_12 MED12 Any mutation 19 13 Signature 15 -0.70 -2.54 0.82 1648.64 1.00 78 17 11 2 TRUE 0.39
uterine cancer KRAS_12 MED12 Any mutation 34 18 Signature 1A -1.47 -3.45 0.15 1498.53 1.00 169 33 17 1 TRUE 0.98
uterine cancer KRAS_12 MED12 Any mutation 13 14 Signature 6 -1.17 -3.27 0.50 1558.01 1.00 75 12 13 1 TRUE 0.65
colorectal cancer KRAS_12 MED12 Any mutation 440 87 Signature overall -0.60 -1.84 0.53 1539.40 1.00 1046 423 70 17 TRUE 0.52
non-small cell lung cancer KRAS_12 MED12 Any mutation 310 97 Signature overall -0.63 -1.73 0.64 1420.33 1.00 648 292 79 18 TRUE 0.53
uterine cancer KRAS_12 MED12 Any mutation 67 87 Signature overall -1.33 -3.31 0.39 1404.24 1.00 339 63 83 4 TRUE 0.83
non-small cell lung cancer KRAS_12 RBM10 Any mutation 13 11 Signature 13 0.62 -0.39 1.63 1404.32 1.00 78 10 8 3 FALSE 0.67
non-small cell lung cancer KRAS_12 RBM10 Any mutation 21 11 Signature 15 0.55 -0.50 1.52 1508.72 1.00 109 18 8 3 FALSE 0.56
non-small cell lung cancer KRAS_12 RBM10 Any mutation 58 17 Signature 18 0.63 -0.18 1.46 1429.06 1.00 85 49 8 9 FALSE 0.94
non-small cell lung cancer KRAS_12 RBM10 Any mutation 44 21 Signature 1A 0.30 -0.60 1.09 1380.06 1.00 205 40 17 4 FALSE 0.31
non-small cell lung cancer KRAS_12 RBM10 Any mutation 79 32 Signature 2 0.83 0.20 1.48 1587.11 1.00 227 65 18 14 FALSE 1.96
non-small cell lung cancer KRAS_12 RBM10 Any mutation 52 30 Signature 3 0.52 -0.21 1.24 1550.18 1.00 173 43 21 9 FALSE 0.82
non-small cell lung cancer KRAS_12 RBM10 Any mutation 234 128 Signature 4 0.53 0.15 0.87 1645.37 1.00 405 180 74 54 FALSE 2.18
non-small cell lung cancer KRAS_12 RBM10 Any mutation 144 20 Signature R2 0.33 -0.49 1.10 1389.88 1.00 49 129 5 15 FALSE 0.40
non-small cell lung cancer KRAS_12 RBM10 Any mutation 17 15 Signature U1 0.44 -0.53 1.36 1457.86 1.00 83 14 12 3 FALSE 0.45
non-small cell lung cancer KRAS_12 RBM10 Any mutation 662 285 Signature overall 0.53 -0.03 1.06 1595.89 1.00 1414 548 171 114 FALSE 1.22
colorectal cancer KRAS_12 NF1 Any mutation 8 24 Signature 10 -1.82 -3.69 -0.35 1570.10 1.00 17 7 23 1 TRUE 1.52
colorectal cancer KRAS_12 NF1 Any mutation 99 21 Signature 15 -1.35 -2.90 -0.22 1462.22 1.00 271 97 19 2 TRUE 1.37
colorectal cancer KRAS_12 NF1 Any mutation 272 40 Signature 1A -0.31 -1.03 0.37 1495.46 1.00 550 260 28 12 TRUE 0.41
colorectal cancer KRAS_12 NF1 Any mutation 69 44 Signature 6 -1.80 -3.21 -0.70 1434.23 1.00 211 67 42 2 TRUE 2.33
non-small cell lung cancer KRAS_12 NF1 Any mutation 57 13 Signature 18 -0.14 -1.11 0.75 1545.03 1.00 87 51 7 6 TRUE 0.11
non-small cell lung cancer KRAS_12 NF1 Any mutation 44 13 Signature 1A -0.61 -1.79 0.51 1533.20 1.00 211 42 11 2 TRUE 0.52
non-small cell lung cancer KRAS_12 NF1 Any mutation 81 39 Signature 2 -0.57 -1.40 0.19 1429.74 1.00 216 74 32 7 TRUE 0.81
non-small cell lung cancer KRAS_12 NF1 Any mutation 13 13 Signature 20 -0.89 -2.20 0.33 1239.14 1.00 53 12 12 1 TRUE 0.77
non-small cell lung cancer KRAS_12 NF1 Any mutation 50 15 Signature 3 -1.07 -2.28 0.00 1501.25 1.00 180 49 14 1 TRUE 1.13
non-small cell lung cancer KRAS_12 NF1 Any mutation 231 113 Signature 4 -0.87 -1.39 -0.39 1317.88 1.00 403 211 93 20 TRUE 3.25
non-small cell lung cancer KRAS_12 NF1 Any mutation 20 11 Signature 7 -1.21 -2.54 -0.02 1467.47 1.00 77 20 11 0 TRUE 1.22
non-small cell lung cancer KRAS_12 NF1 Any mutation 145 12 Signature R2 -0.92 -1.81 -0.04 1388.14 1.00 48 139 6 6 TRUE 1.35
uterine cancer KRAS_12 NF1 Any mutation 34 21 Signature 1A -0.28 -1.65 0.92 1626.03 1.00 172 31 18 3 TRUE 0.17
uterine cancer KRAS_12 NF1 Any mutation 13 24 Signature 6 -0.68 -2.30 0.76 1520.34 1.00 67 11 22 2 TRUE 0.43
colorectal cancer KRAS_12 NF1 Any mutation 448 129 Signature overall -1.31 -2.78 -0.11 1438.67 1.00 1049 431 112 17 TRUE 1.28
non-small cell lung cancer KRAS_12 NF1 Any mutation 641 229 Signature overall -0.78 -1.51 -0.09 1599.84 1.00 1275 598 186 43 TRUE 1.52
uterine cancer KRAS_12 NF1 Any mutation 48 92 Signature overall -0.46 -2.74 1.75 1459.59 1.00 257 42 86 6 TRUE 0.17
non-small cell lung cancer KRAS_12 FLT1 Any mutation 58 13 Signature 18 0.42 -0.41 1.31 1587.11 1.00 87 51 6 7 FALSE 0.47
non-small cell lung cancer KRAS_12 FLT1 Any mutation 79 12 Signature 2 0.33 -0.54 1.27 1359.36 1.00 238 74 7 5 FALSE 0.34
non-small cell lung cancer KRAS_12 FLT1 Any mutation 233 64 Signature 4 -0.07 -0.66 0.47 1465.61 1.00 433 215 46 18 FALSE 0.10
non-small cell lung cancer KRAS_12 FLT1 Any mutation 370 89 Signature overall 0.23 -0.58 1.14 1545.80 1.00 758 340 59 30 FALSE 0.23
uterine cancer KRAS_12 RASA1 Any mutation 34 20 Signature 1A -2.26 -5.21 -0.14 1548.09 1.00 171 33 19 1 FALSE 1.08
uterine cancer KRAS_12 RASA1 Any mutation 13 12 Signature 6 -3.67 -8.36 -0.57 1489.25 1.00 74 13 12 0 FALSE 1.08
uterine cancer KRAS_12 RASA1 Any mutation 48 78 Signature overall -3.07 -6.95 -0.18 1593.53 1.00 262 47 77 1 FALSE 1.19
colorectal cancer KRAS_12 EPHA5 Any mutation 8 26 Signature 10 -2.72 -5.37 -0.87 1356.71 1.00 15 8 26 0 FALSE 1.76
colorectal cancer KRAS_12 EPHA5 Any mutation 99 18 Signature 15 -0.86 -2.10 0.19 1300.39 1.00 275 96 15 3 FALSE 0.80
colorectal cancer KRAS_12 EPHA5 Any mutation 271 49 Signature 1A -0.10 -0.74 0.50 1501.44 1.00 543 255 33 16 FALSE 0.13
colorectal cancer KRAS_12 EPHA5 Any mutation 69 36 Signature 6 -1.68 -3.25 -0.50 1423.59 1.00 213 67 34 2 FALSE 1.81
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 58 24 Signature 18 0.05 -0.70 0.83 1343.60 1.00 79 49 15 9 FALSE 0.05
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 79 30 Signature 2 0.23 -0.53 0.95 1574.85 1.00 227 70 21 9 FALSE 0.27
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 50 19 Signature 3 0.53 -0.34 1.47 1470.32 1.00 184 43 12 7 FALSE 0.61
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 233 109 Signature 4 -0.01 -0.43 0.40 1431.24 1.00 410 198 74 35 FALSE 0.01
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 144 12 Signature R2 -0.38 -1.32 0.56 1427.18 1.00 50 137 5 7 FALSE 0.38
colorectal cancer KRAS_12 EPHA5 Any mutation 447 129 Signature overall -1.30 -2.85 0.18 1231.61 1.00 1046 426 108 21 FALSE 1.04
non-small cell lung cancer KRAS_12 EPHA5 Any mutation 564 194 Signature overall 0.07 -0.66 0.81 1440.14 1.00 950 497 127 67 FALSE 0.07
colorectal cancer KRAS_12 AR Any mutation 99 21 Signature 15 -0.94 -2.04 -0.01 1379.23 1.00 271 97 19 2 TRUE 1.21
colorectal cancer KRAS_12 AR Any mutation 270 33 Signature 1A -0.70 -1.46 -0.01 1457.65 1.00 549 263 26 7 TRUE 1.27
colorectal cancer KRAS_12 AR Any mutation 69 37 Signature 6 -0.58 -1.33 0.20 1538.74 1.00 216 63 31 6 TRUE 0.86
non-small cell lung cancer KRAS_12 AR Any mutation 232 56 Signature 4 -0.23 -0.82 0.33 1060.09 1.01 437 216 40 16 TRUE 0.37
colorectal cancer KRAS_12 AR Any mutation 438 91 Signature overall -0.74 -1.59 0.06 1489.80 1.00 1036 423 76 15 TRUE 1.10
non-small cell lung cancer KRAS_12 AR Any mutation 232 56 Signature overall -0.20 -4.63 4.33 1264.76 1.00 437 216 40 16 TRUE 0.04
colorectal cancer KRAS_12 ROS1 Any mutation 8 30 Signature 10 -2.31 -4.39 -0.69 1450.30 1.00 16 7 29 1 TRUE 1.78
colorectal cancer KRAS_12 ROS1 Any mutation 270 28 Signature 1A -1.55 -2.82 -0.51 1511.35 1.00 552 267 25 3 TRUE 2.07
colorectal cancer KRAS_12 ROS1 Any mutation 69 26 Signature 6 -1.13 -2.55 0.06 1418.49 1.00 219 66 23 3 TRUE 1.05
non-small cell lung cancer KRAS_12 ROS1 Any mutation 79 14 Signature 2 -1.86 -3.36 -0.54 1624.81 1.00 233 78 13 1 TRUE 1.91
non-small cell lung cancer KRAS_12 ROS1 Any mutation 230 42 Signature 4 -1.93 -3.13 -0.88 1526.17 1.00 435 227 39 3 TRUE 3.07
colorectal cancer KRAS_12 ROS1 Any mutation 347 84 Signature overall -1.60 -3.48 0.30 1495.08 1.00 787 340 77 7 TRUE 1.00
non-small cell lung cancer KRAS_12 ROS1 Any mutation 309 56 Signature overall -1.89 -3.39 -0.43 1417.88 1.00 668 305 52 4 TRUE 1.81
colorectal cancer KRAS_12 PIK3CG Any mutation 10 22 Signature 10 -0.32 -1.62 0.81 1646.03 1.00 16 6 18 4 FALSE 0.21
colorectal cancer KRAS_12 PIK3CG Any mutation 99 17 Signature 15 0.22 -0.86 1.21 1491.24 1.00 277 93 11 6 FALSE 0.17
colorectal cancer KRAS_12 PIK3CG Any mutation 270 29 Signature 1A -0.79 -1.70 0.00 1337.94 1.00 551 265 24 5 FALSE 1.15
colorectal cancer KRAS_12 PIK3CG Any mutation 69 29 Signature 6 -0.18 -1.08 0.69 1549.42 1.00 222 63 23 6 FALSE 0.15
non-small cell lung cancer KRAS_12 PIK3CG Any mutation 13 13 Signature 13 -0.61 -2.34 0.76 1506.93 1.00 74 12 12 1 FALSE 0.36
non-small cell lung cancer KRAS_12 PIK3CG Any mutation 81 18 Signature 2 1.05 0.13 1.98 1259.15 1.00 237 71 8 10 FALSE 1.57
non-small cell lung cancer KRAS_12 PIK3CG Any mutation 231 75 Signature 4 -0.32 -0.85 0.18 1347.29 1.00 423 211 55 20 FALSE 0.65
non-small cell lung cancer KRAS_12 PIK3CG Any mutation 144 12 Signature R2 -1.06 -2.17 0.01 1463.48 1.00 48 139 7 5 FALSE 1.18
colorectal cancer KRAS_12 PIK3CG Any mutation 448 97 Signature overall -0.26 -1.44 0.96 1523.34 1.00 1066 427 76 21 FALSE 0.17
non-small cell lung cancer KRAS_12 PIK3CG Any mutation 469 118 Signature overall -0.24 -1.55 1.05 1532.41 1.00 782 433 82 36 FALSE 0.14
non-small cell lung cancer KRAS_12 EGFR Any mutation 13 23 Signature 13 -3.25 -4.31 -2.22 1531.00 1.00 65 12 22 1 TRUE 8.74
non-small cell lung cancer KRAS_12 EGFR Any mutation 17 12 Signature 14 -3.24 -4.36 -2.19 1534.17 1.00 30 16 11 1 TRUE 8.68
non-small cell lung cancer KRAS_12 EGFR Any mutation 20 54 Signature 15 -3.51 -4.58 -2.53 1367.78 1.00 71 20 54 0 TRUE 10.22
non-small cell lung cancer KRAS_12 EGFR Any mutation 8 19 Signature 16 -3.45 -4.60 -2.44 1532.51 1.00 34 8 19 0 TRUE 9.78
non-small cell lung cancer KRAS_12 EGFR Any mutation 57 29 Signature 18 -3.58 -4.68 -2.60 1481.34 1.00 68 57 29 0 TRUE 11.26
non-small cell lung cancer KRAS_12 EGFR Any mutation 14 16 Signature 19 -3.47 -4.63 -2.49 1185.71 1.00 33 14 16 0 TRUE 9.45
non-small cell lung cancer KRAS_12 EGFR Any mutation 44 197 Signature 1A -3.81 -4.83 -2.92 1532.92 1.00 97 44 197 0 TRUE 14.13
non-small cell lung cancer KRAS_12 EGFR Any mutation 79 79 Signature 2 -3.46 -4.52 -2.56 1453.15 1.00 183 78 78 1 TRUE 11.83
non-small cell lung cancer KRAS_12 EGFR Any mutation 13 35 Signature 20 -3.51 -4.57 -2.51 1525.14 1.00 36 13 35 0 TRUE 10.42
non-small cell lung cancer KRAS_12 EGFR Any mutation 9 29 Signature 21 -3.49 -4.62 -2.41 1481.22 1.00 31 9 29 0 TRUE 9.22
non-small cell lung cancer KRAS_12 EGFR Any mutation 50 89 Signature 3 -3.12 -4.13 -2.19 1392.14 1.00 115 47 86 3 TRUE 9.96
non-small cell lung cancer KRAS_12 EGFR Any mutation 230 114 Signature 4 -2.83 -3.65 -2.12 1552.83 1.00 386 223 107 7 TRUE 12.73
non-small cell lung cancer KRAS_12 EGFR Any mutation 11 18 Signature 6 -3.48 -4.55 -2.47 1468.05 1.00 29 11 18 0 TRUE 9.80
non-small cell lung cancer KRAS_12 EGFR Any mutation 20 34 Signature 7 -3.50 -4.64 -2.44 1429.76 1.00 58 20 34 0 TRUE 10.12
non-small cell lung cancer KRAS_12 EGFR Any mutation 26 14 Signature 8 -3.29 -4.34 -2.23 1489.66 1.00 25 25 13 1 TRUE 9.28
non-small cell lung cancer KRAS_12 EGFR Any mutation 6 11 Signature R3 -3.43 -4.60 -2.33 1429.75 1.00 15 6 11 0 TRUE 8.67
non-small cell lung cancer KRAS_12 EGFR Any mutation 17 46 Signature U1 -3.51 -4.65 -2.41 1374.40 1.00 53 17 46 0 TRUE 9.73
non-small cell lung cancer KRAS_12 EGFR Any mutation 640 853 Signature overall -3.41 -4.07 -2.82 1427.29 1.00 1372 626 839 14 TRUE 24.98
colorectal cancer KRAS_12 ARID1B Any mutation 99 22 Signature 15 -1.34 -2.48 -0.24 1379.12 1.00 271 96 19 3 TRUE 1.70
colorectal cancer KRAS_12 ARID1B Any mutation 271 53 Signature 1A -1.41 -2.27 -0.65 1380.04 1.00 537 264 46 7 TRUE 3.22
colorectal cancer KRAS_12 ARID1B Any mutation 69 46 Signature 6 -2.34 -4.24 -1.16 1384.17 1.00 204 69 46 0 TRUE 2.38
non-small cell lung cancer KRAS_12 ARID1B Any mutation 79 13 Signature 2 0.14 -0.80 1.33 1470.64 1.00 237 74 8 5 TRUE 0.10
non-small cell lung cancer KRAS_12 ARID1B Any mutation 230 42 Signature 4 -0.46 -1.24 0.24 1433.96 1.00 441 221 33 9 TRUE 0.66
uterine cancer KRAS_12 ARID1B Any mutation 34 17 Signature 1A -0.02 -1.34 1.10 1391.14 1.00 172 31 14 3 TRUE 0.01
uterine cancer KRAS_12 ARID1B Any mutation 13 39 Signature 6 -0.26 -1.45 0.83 1560.68 1.00 58 9 35 4 TRUE 0.18
colorectal cancer KRAS_12 ARID1B Any mutation 439 121 Signature overall -1.69 -2.94 -0.59 1379.97 1.00 1012 429 111 10 TRUE 2.22
non-small cell lung cancer KRAS_12 ARID1B Any mutation 309 55 Signature overall -0.15 -1.42 1.31 1696.88 1.00 678 295 41 14 TRUE 0.08
uterine cancer KRAS_12 ARID1B Any mutation 48 78 Signature overall -0.07 -1.88 1.96 1424.27 1.00 257 40 70 8 TRUE 0.03
non-small cell lung cancer KRAS_12 MET Any mutation 79 23 Signature 2 -0.99 -2.27 -0.07 1447.62 1.00 226 78 22 1 TRUE 1.13
non-small cell lung cancer KRAS_12 MET Any mutation 50 11 Signature 3 -0.64 -1.66 0.30 1533.67 1.00 185 48 9 2 TRUE 0.70
non-small cell lung cancer KRAS_12 MET Any mutation 230 34 Signature 4 -0.55 -1.26 0.18 1560.60 1.00 451 221 25 9 TRUE 0.85
non-small cell lung cancer KRAS_12 MET Any mutation 359 68 Signature overall -0.73 -1.71 0.14 1500.09 1.00 862 347 56 12 TRUE 0.95
colorectal cancer KRAS_12 BRAF Any mutation 99 48 Signature 15 -2.19 -3.16 -1.31 1414.90 1.00 243 96 45 3 TRUE 5.81
colorectal cancer KRAS_12 BRAF Any mutation 271 99 Signature 1A -2.19 -2.92 -1.50 1456.98 1.00 485 264 92 7 TRUE 8.89
colorectal cancer KRAS_12 BRAF Any mutation 69 60 Signature 6 -2.56 -3.86 -1.66 1397.94 1.00 188 69 60 0 TRUE 4.52
non-small cell lung cancer KRAS_12 BRAF Any mutation 57 11 Signature 18 -1.20 -2.12 -0.38 1266.98 1.00 83 56 10 1 TRUE 2.07
non-small cell lung cancer KRAS_12 BRAF Any mutation 79 20 Signature 2 -1.15 -2.05 -0.39 1429.89 1.00 227 77 18 2 TRUE 2.20
non-small cell lung cancer KRAS_12 BRAF Any mutation 50 20 Signature 3 -1.22 -2.19 -0.40 1489.60 1.00 174 49 19 1 TRUE 2.16
non-small cell lung cancer KRAS_12 BRAF Any mutation 230 50 Signature 4 -0.96 -1.64 -0.33 1417.05 1.00 434 220 40 10 TRUE 2.42
colorectal cancer KRAS_12 BRAF Any mutation 439 207 Signature overall -2.31 -3.24 -1.52 1505.11 1.00 916 429 197 10 TRUE 6.77
non-small cell lung cancer KRAS_12 BRAF Any mutation 416 101 Signature overall -1.13 -1.89 -0.47 1372.42 1.00 918 402 87 14 TRUE 2.67
colorectal cancer KRAS_12 B2M Any mutation 8 14 Signature 10 -1.47 -3.33 -0.07 1510.84 1.00 19 8 14 0 FALSE 1.13
colorectal cancer KRAS_12 B2M Any mutation 97 20 Signature 15 -0.64 -1.65 0.34 1481.10 1.00 271 93 16 4 FALSE 0.68
colorectal cancer KRAS_12 B2M Any mutation 263 46 Signature 1A -0.76 -1.51 -0.14 1411.59 1.00 539 254 37 9 FALSE 1.49
colorectal cancer KRAS_12 B2M Any mutation 69 51 Signature 6 -0.72 -1.49 0.07 1431.72 1.00 208 62 44 7 FALSE 1.18
colorectal cancer KRAS_12 B2M Any mutation 437 131 Signature overall -0.90 -1.99 0.10 1453.39 1.00 1037 417 111 20 FALSE 1.05
colorectal cancer KRAS_12 CARD11 Any mutation 99 14 Signature 15 -0.45 -1.38 0.44 1658.42 1.00 275 96 11 3 FALSE 0.46
colorectal cancer KRAS_12 CARD11 Any mutation 272 58 Signature 1A -0.17 -0.74 0.39 1449.00 1.00 538 254 40 18 FALSE 0.26
colorectal cancer KRAS_12 CARD11 Any mutation 69 38 Signature 6 -0.67 -1.55 0.12 1565.08 1.00 216 65 34 4 FALSE 0.93
non-small cell lung cancer KRAS_12 CARD11 Any mutation 81 16 Signature 2 0.46 -0.52 1.53 1215.01 1.00 236 74 9 7 FALSE 0.42
non-small cell lung cancer KRAS_12 CARD11 Any mutation 230 63 Signature 4 -0.28 -0.88 0.27 1422.53 1.00 429 214 47 16 FALSE 0.47
colorectal cancer KRAS_12 CARD11 Any mutation 440 110 Signature overall -0.42 -1.36 0.47 1539.22 1.00 1029 415 85 25 FALSE 0.44
non-small cell lung cancer KRAS_12 CARD11 Any mutation 311 79 Signature overall 0.07 -1.46 1.50 1485.11 1.00 665 288 56 23 FALSE 0.04
non-small cell lung cancer KRAS_12 INPP4B Any mutation 80 15 Signature 2 0.91 -0.05 2.08 1225.70 1.00 239 72 7 8 FALSE 1.05
non-small cell lung cancer KRAS_12 INPP4B Any mutation 231 60 Signature 4 0.07 -0.51 0.61 1076.57 1.00 438 212 41 19 FALSE 0.10
non-small cell lung cancer KRAS_12 INPP4B Any mutation 311 75 Signature overall 0.49 -1.04 2.15 1534.42 1.00 677 284 48 27 FALSE 0.26
non-small cell lung cancer KRAS_12 NFE2L2 Any mutation 13 15 Signature 13 -0.72 -2.30 0.66 1525.72 1.00 74 12 14 1 FALSE 0.48
non-small cell lung cancer KRAS_12 NFE2L2 Any mutation 79 32 Signature 2 -0.61 -1.57 0.28 1409.03 1.00 225 74 27 5 FALSE 0.72
non-small cell lung cancer KRAS_12 NFE2L2 Any mutation 231 20 Signature 4 -0.38 -1.28 0.49 1491.52 1.00 458 225 14 6 FALSE 0.40
non-small cell lung cancer KRAS_12 NFE2L2 Any mutation 323 67 Signature overall -0.56 -1.77 0.73 1540.24 1.00 757 311 55 12 FALSE 0.43
colorectal cancer KRAS_12 SOX9 Any mutation 101 40 Signature 15 -0.04 -0.67 0.55 1242.58 1.00 256 91 30 10 FALSE 0.04
colorectal cancer KRAS_12 SOX9 Any mutation 274 105 Signature 1A 0.43 0.04 0.84 1519.31 1.00 521 228 59 46 FALSE 1.46
colorectal cancer KRAS_12 SOX9 Any mutation 69 59 Signature 6 -0.22 -0.94 0.40 1452.66 1.00 199 60 50 9 FALSE 0.29
colorectal cancer KRAS_12 SOX9 Any mutation 444 204 Signature overall 0.04 -0.66 0.70 1370.10 1.00 976 379 139 65 FALSE 0.05
colorectal cancer KRAS_12 SMAD2 Any mutation 99 16 Signature 15 0.43 -0.29 1.07 1485.23 1.00 275 94 11 5 TRUE 0.64
colorectal cancer KRAS_12 SMAD2 Any mutation 272 33 Signature 1A 0.59 0.02 1.16 1461.45 1.00 562 255 16 17 TRUE 1.38
colorectal cancer KRAS_12 SMAD2 Any mutation 69 17 Signature 6 0.41 -0.35 1.04 1528.46 1.00 231 65 13 4 TRUE 0.57
colorectal cancer KRAS_12 SMAD2 Any mutation 440 66 Signature overall 0.47 -0.22 1.08 1397.66 1.00 1068 414 40 26 TRUE 0.82
non-small cell lung cancer KRAS_12 GLI1 Any mutation 219 44 Signature 4 0.29 -0.38 0.90 1374.42 1.00 392 201 26 18 FALSE 0.42
non-small cell lung cancer KRAS_12 GLI1 Any mutation 219 44 Signature overall 0.32 -4.09 4.77 1405.90 1.00 392 201 26 18 FALSE 0.06
colorectal cancer KRAS_12 ZFHX3 Any mutation 9 17 Signature 10 -0.88 -2.15 0.21 1439.58 1.00 14 7 15 2 FALSE 0.85
colorectal cancer KRAS_12 ZFHX3 Any mutation 90 31 Signature 15 -0.59 -1.43 0.16 1524.94 1.00 244 84 25 6 FALSE 0.83
colorectal cancer KRAS_12 ZFHX3 Any mutation 257 80 Signature 1A -0.80 -1.35 -0.25 1449.02 1.00 487 242 65 15 FALSE 2.38
colorectal cancer KRAS_12 ZFHX3 Any mutation 68 81 Signature 6 -0.84 -1.48 -0.21 1530.20 1.00 177 58 71 10 FALSE 2.02
non-small cell lung cancer KRAS_12 ZFHX3 Any mutation 75 18 Signature 2 -0.73 -1.88 0.30 1465.79 1.00 200 72 15 3 FALSE 0.72
non-small cell lung cancer KRAS_12 ZFHX3 Any mutation 219 61 Signature 4 -0.40 -0.96 0.20 1567.73 1.00 375 202 44 17 FALSE 0.74
non-small cell lung cancer KRAS_12 ZFHX3 Any mutation 129 14 Signature R2 -1.14 -2.19 -0.14 1410.44 1.00 40 123 8 6 FALSE 1.56
uterine cancer KRAS_12 ZFHX3 Any mutation 19 13 Signature 15 0.75 -0.44 1.90 1359.75 1.00 76 14 8 5 FALSE 0.71
uterine cancer KRAS_12 ZFHX3 Any mutation 31 56 Signature 1A -0.59 -1.56 0.29 1588.43 1.00 132 26 51 5 FALSE 0.66
uterine cancer KRAS_12 ZFHX3 Any mutation 13 45 Signature 6 0.59 -0.47 1.67 1278.34 1.00 52 5 37 8 FALSE 0.55
colorectal cancer KRAS_12 ZFHX3 Any mutation 424 209 Signature overall -0.76 -1.64 0.09 1446.77 1.00 922 391 176 33 FALSE 1.14
non-small cell lung cancer KRAS_12 ZFHX3 Any mutation 423 93 Signature overall -0.73 -2.02 0.55 1508.52 1.00 615 397 67 26 FALSE 0.59
uterine cancer KRAS_12 ZFHX3 Any mutation 69 184 Signature overall 0.08 -1.20 1.34 1534.35 1.00 286 47 162 22 FALSE 0.05
colorectal cancer KRAS_12 MGA Any mutation 8 15 Signature 10 -1.77 -4.18 -0.22 1591.32 1.00 15 8 15 0 FALSE 1.05
colorectal cancer KRAS_12 MGA Any mutation 89 16 Signature 15 -0.71 -1.94 0.39 1530.40 1.00 246 86 13 3 FALSE 0.63
colorectal cancer KRAS_12 MGA Any mutation 256 42 Signature 1A -0.23 -0.90 0.40 1425.86 1.00 508 243 29 13 FALSE 0.31
colorectal cancer KRAS_12 MGA Any mutation 66 36 Signature 6 -0.96 -2.06 -0.05 1468.52 1.00 195 62 32 4 FALSE 1.28
non-small cell lung cancer KRAS_12 MGA Any mutation 75 28 Signature 2 -0.66 -1.68 0.24 1155.66 1.00 202 71 24 4 FALSE 0.74
non-small cell lung cancer KRAS_12 MGA Any mutation 220 79 Signature 4 -0.20 -0.72 0.27 1361.30 1.00 366 196 55 24 FALSE 0.38
non-small cell lung cancer KRAS_12 MGA Any mutation 129 13 Signature R2 -0.01 -0.98 1.05 1441.71 1.00 45 119 3 10 FALSE 0.01
uterine cancer KRAS_12 MGA Any mutation 31 19 Signature 1A -3.39 -10.07 -0.54 1232.35 1.00 154 31 19 0 FALSE 0.84
uterine cancer KRAS_12 MGA Any mutation 12 14 Signature 6 -3.16 -8.78 -0.12 1251.17 1.00 66 12 14 0 FALSE 0.81
colorectal cancer KRAS_12 MGA Any mutation 419 109 Signature overall -0.92 -2.20 0.25 1478.81 1.00 964 399 89 20 FALSE 0.87
non-small cell lung cancer KRAS_12 MGA Any mutation 424 120 Signature overall -0.27 -1.39 0.86 1401.64 1.00 613 386 82 38 FALSE 0.19
uterine cancer KRAS_12 MGA Any mutation 48 82 Signature overall -1.67 -5.41 1.58 1383.43 1.00 240 43 77 5 FALSE 0.47
colorectal cancer KRAS_12 KMT2B Any mutation 50 18 Signature 15 -1.52 -3.16 -0.30 1538.62 1.00 132 49 17 1 FALSE 1.45
colorectal cancer KRAS_12 KMT2B Any mutation 152 64 Signature 1A -0.62 -1.22 0.00 1452.55 1.00 271 137 49 15 FALSE 1.34
colorectal cancer KRAS_12 KMT2B Any mutation 48 86 Signature 6 -1.07 -1.82 -0.42 1675.65 1.00 84 37 75 11 FALSE 2.55
colorectal cancer KRAS_12 KMT2B Any mutation 250 168 Signature overall -1.06 -2.35 0.09 1343.48 1.00 487 223 141 27 FALSE 1.09
colorectal cancer KRAS_12 TCF7L2 Any mutation 91 48 Signature 15 0.21 -0.34 0.77 1420.01 1.00 228 76 33 15 FALSE 0.33
colorectal cancer KRAS_12 TCF7L2 Any mutation 260 115 Signature 1A 0.05 -0.33 0.45 1392.98 1.00 465 222 77 38 FALSE 0.10
colorectal cancer KRAS_12 TCF7L2 Any mutation 34 12 Signature 2 0.69 -0.09 1.70 1571.68 1.00 36 24 2 10 FALSE 0.87
colorectal cancer KRAS_12 TCF7L2 Any mutation 67 69 Signature 6 -0.16 -0.76 0.39 1487.63 1.00 173 55 57 12 FALSE 0.23
colorectal cancer KRAS_12 TCF7L2 Any mutation 452 244 Signature overall 0.20 -0.38 0.86 1338.18 1.00 902 377 169 75 FALSE 0.28
colorectal cancer KRAS_12 ANKRD11 Any mutation 10 12 Signature 10 -0.65 -1.88 0.56 1394.35 1.00 16 7 9 3 FALSE 0.52
colorectal cancer KRAS_12 ANKRD11 Any mutation 85 17 Signature 15 -1.47 -2.89 -0.34 1505.42 1.00 242 84 16 1 FALSE 1.59
colorectal cancer KRAS_12 ANKRD11 Any mutation 247 47 Signature 1A -0.87 -1.62 -0.16 1479.84 1.00 489 238 38 9 FALSE 1.76
colorectal cancer KRAS_12 ANKRD11 Any mutation 63 57 Signature 6 -1.59 -2.64 -0.68 1512.18 1.00 180 60 54 3 FALSE 2.82
colorectal cancer KRAS_12 ANKRD11 Any mutation 405 133 Signature overall -1.12 -2.20 -0.14 1412.70 1.00 927 389 117 16 FALSE 1.48
colorectal cancer KRAS_12 POLD1 Any mutation 89 15 Signature 15 -2.05 -4.61 -0.54 1538.64 1.00 249 89 15 0 TRUE 1.34
colorectal cancer KRAS_12 POLD1 Any mutation 258 43 Signature 1A -0.36 -1.07 0.31 1345.24 1.00 509 245 30 13 TRUE 0.49
colorectal cancer KRAS_12 POLD1 Any mutation 66 44 Signature 6 -1.70 -3.04 -0.64 1350.32 1.00 192 64 42 2 TRUE 2.18
colorectal cancer KRAS_12 POLD1 Any mutation 413 102 Signature overall -1.33 -2.84 -0.11 1597.18 1.00 950 398 87 15 TRUE 1.20
non-small cell lung cancer KRAS_12 PREX2 Any mutation 126 52 Signature 4 -0.19 -0.82 0.44 1349.27 1.00 208 110 36 16 FALSE 0.26
non-small cell lung cancer KRAS_12 PREX2 Any mutation 126 52 Signature overall -0.10 -4.06 4.10 1441.97 1.00 208 110 36 16 FALSE 0.02
colorectal cancer KRAS_12 AMER1 Any mutation 99 34 Signature 15 0.22 -0.38 0.82 1537.93 1.00 263 89 24 10 FALSE 0.34
colorectal cancer KRAS_12 AMER1 Any mutation 270 61 Signature 1A 0.30 -0.14 0.76 1264.17 1.00 545 245 36 25 FALSE 0.72
colorectal cancer KRAS_12 AMER1 Any mutation 69 36 Signature 6 0.18 -0.45 0.74 1435.31 1.00 219 61 28 8 FALSE 0.26
non-small cell lung cancer KRAS_12 AMER1 Any mutation 79 11 Signature 2 0.59 -0.60 1.85 1256.81 1.00 239 74 6 5 FALSE 0.47
non-small cell lung cancer KRAS_12 AMER1 Any mutation 232 83 Signature 4 -0.21 -0.72 0.30 1604.24 1.00 427 209 60 23 FALSE 0.38
colorectal cancer KRAS_12 AMER1 Any mutation 438 131 Signature overall 0.23 -0.34 0.78 1539.38 1.00 1027 395 88 43 FALSE 0.38
non-small cell lung cancer KRAS_12 AMER1 Any mutation 311 94 Signature overall 0.16 -1.76 2.19 1486.36 1.00 666 283 66 28 FALSE 0.06
non-small cell lung cancer KRAS_12 EPHA7 Any mutation 44 13 Signature 3 -0.36 -1.55 0.82 1529.02 1.00 163 41 10 3 FALSE 0.26
non-small cell lung cancer KRAS_12 EPHA7 Any mutation 217 51 Signature 4 -0.86 -1.61 -0.21 1575.01 1.00 377 208 42 9 FALSE 1.78
non-small cell lung cancer KRAS_12 EPHA7 Any mutation 261 64 Signature overall -0.59 -2.01 0.89 1375.65 1.00 540 249 52 12 FALSE 0.38
non-small cell lung cancer RAS_12C SPEN Any mutation 21 39 Signature 2 -2.57 -7.02 -0.23 1506.65 1.00 291 21 39 0 FALSE 0.89
non-small cell lung cancer RAS_12C SPEN Any mutation 36 24 Signature 4 -1.41 -4.33 0.76 1376.07 1.00 646 35 23 1 FALSE 0.57
non-small cell lung cancer RAS_12C SPEN Any mutation 57 63 Signature overall -1.86 -5.27 0.72 1442.84 1.00 937 56 62 1 FALSE 0.67
non-small cell lung cancer RAS_12C KMT2C Any mutation 21 40 Signature 2 0.15 -0.90 1.13 1511.16 1.00 268 18 37 3 FALSE 0.11
non-small cell lung cancer RAS_12C KMT2C Any mutation 36 76 Signature 4 0.21 -0.68 1.05 1507.10 1.00 601 31 71 5 FALSE 0.20
non-small cell lung cancer RAS_12C KMT2C Any mutation 64 151 Signature overall 0.17 -0.90 1.24 1466.66 1.00 1171 55 142 9 FALSE 0.12
non-small cell lung cancer RAS_12C TP53 Any mutation 15 92 Signature 18 -0.37 -1.16 0.42 1467.47 1.00 57 7 84 8 TRUE 0.44
non-small cell lung cancer RAS_12C TP53 Any mutation 21 223 Signature 2 -0.32 -1.00 0.38 1464.91 1.00 116 8 210 13 TRUE 0.45
non-small cell lung cancer RAS_12C TP53 Any mutation 36 522 Signature 4 -1.29 -1.92 -0.71 1314.06 1.00 202 24 510 12 TRUE 4.68
non-small cell lung cancer RAS_12C TP53 Any mutation 50 85 Signature R2 -0.90 -1.53 -0.30 1629.14 1.00 82 39 74 11 TRUE 2.36
non-small cell lung cancer RAS_12C TP53 Any mutation 168 1927 Signature overall -0.76 -1.23 -0.31 1527.10 1.00 1130 100 1859 68 TRUE 2.89
non-small cell lung cancer RAS_12C ATRX Any mutation 15 12 Signature 18 -0.69 -3.12 0.61 1364.70 1.00 124 15 12 0 TRUE 0.33
non-small cell lung cancer RAS_12C ATRX Any mutation 21 28 Signature 2 -0.76 -3.18 0.45 1174.58 1.00 278 21 28 0 TRUE 0.38
non-small cell lung cancer RAS_12C ATRX Any mutation 37 88 Signature 4 0.04 -0.94 0.91 1384.45 1.00 600 30 81 7 TRUE 0.03
non-small cell lung cancer RAS_12C ATRX Any mutation 73 128 Signature overall -0.47 -2.21 0.66 1540.68 1.00 1002 66 121 7 TRUE 0.29
non-small cell lung cancer RAS_12C ATR Any mutation 21 16 Signature 2 0.41 -0.77 1.56 1357.80 1.00 289 19 14 2 FALSE 0.30
non-small cell lung cancer RAS_12C ATR Any mutation 36 60 Signature 4 0.16 -0.98 1.10 1001.98 1.00 611 33 57 3 FALSE 0.12
non-small cell lung cancer RAS_12C ATR Any mutation 59 87 Signature overall 0.34 -0.83 1.47 1366.75 1.00 986 53 81 6 FALSE 0.23
non-small cell lung cancer RAS_12C PDGFRA Any mutation 21 20 Signature 2 0.92 -0.27 1.82 1172.48 1.00 285 19 18 2 TRUE 1.18
non-small cell lung cancer RAS_12C PDGFRA Any mutation 38 70 Signature 4 1.23 0.59 1.92 180.68 1.03 611 27 59 11 TRUE 3.57
non-small cell lung cancer RAS_12C PDGFRA Any mutation 59 90 Signature overall 1.06 -0.18 2.12 1572.33 1.00 896 46 77 13 TRUE 1.27
non-small cell lung cancer RAS_12C FLT4 Any mutation 21 11 Signature 2 -0.30 -2.36 1.16 94.39 1.06 293 20 10 1 TRUE 0.13
non-small cell lung cancer RAS_12C FLT4 Any mutation 36 36 Signature 4 -0.43 -2.40 0.80 35.36 1.11 633 35 35 1 TRUE 0.20
non-small cell lung cancer RAS_12C FLT4 Any mutation 57 47 Signature overall -0.38 -2.53 1.14 70.99 1.06 926 55 45 2 TRUE 0.15
non-small cell lung cancer RAS_12C PTPRD Any mutation 15 22 Signature 18 0.06 -1.25 1.17 1316.99 1.00 118 13 20 2 FALSE 0.03
non-small cell lung cancer RAS_12C PTPRD Any mutation 21 33 Signature 2 0.79 -0.25 1.80 1441.80 1.00 276 16 28 5 FALSE 0.89
non-small cell lung cancer RAS_12C PTPRD Any mutation 40 195 Signature 4 -0.13 -0.93 0.55 1495.97 1.00 521 31 186 9 FALSE 0.15
non-small cell lung cancer RAS_12C PTPRD Any mutation 50 18 Signature R2 0.76 -0.12 1.64 1585.58 1.00 140 42 10 8 FALSE 1.02
non-small cell lung cancer RAS_12C PTPRD Any mutation 138 321 Signature overall 0.20 -0.75 1.04 1358.61 1.00 1625 113 296 25 FALSE 0.18
non-small cell lung cancer RAS_12C PIK3C2G Any mutation 21 17 Signature 2 -2.33 -5.21 -0.18 88.06 1.03 285 21 17 0 FALSE 0.97
non-small cell lung cancer RAS_12C PIK3C2G Any mutation 36 57 Signature 4 -2.11 -4.66 -0.12 52.49 1.05 614 35 56 1 FALSE 0.96
non-small cell lung cancer RAS_12C PIK3C2G Any mutation 57 74 Signature overall -2.20 -4.83 -0.07 66.02 1.04 899 56 73 1 FALSE 0.95
non-small cell lung cancer RAS_12C CREBBP Any mutation 21 15 Signature 2 -0.75 -2.69 0.74 1279.44 1.00 288 21 15 0 TRUE 0.39
non-small cell lung cancer RAS_12C CREBBP Any mutation 36 44 Signature 4 -0.27 -1.77 0.88 1052.36 1.00 630 33 41 3 TRUE 0.16
non-small cell lung cancer RAS_12C CREBBP Any mutation 66 82 Signature overall -0.56 -2.23 0.78 1139.39 1.00 1395 63 79 3 TRUE 0.33
non-small cell lung cancer RAS_12C DOT1L Any mutation 21 16 Signature 2 -0.17 -1.77 1.07 1208.18 1.00 288 20 15 1 FALSE 0.09
non-small cell lung cancer RAS_12C DOT1L Any mutation 36 38 Signature 4 -0.15 -1.56 0.97 1138.64 1.00 631 34 36 2 FALSE 0.09
non-small cell lung cancer RAS_12C DOT1L Any mutation 57 54 Signature overall -0.17 -1.69 1.06 1064.81 1.00 919 54 51 3 FALSE 0.09
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 15 14 Signature 18 0.44 -0.89 1.61 1493.35 1.00 125 12 11 3 FALSE 0.32
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 22 33 Signature 2 0.37 -0.66 1.39 1479.52 1.00 280 18 29 4 FALSE 0.32
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 36 104 Signature 4 -0.11 -1.04 0.70 1502.97 1.00 574 31 99 5 FALSE 0.09
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 49 15 Signature R2 -0.79 -2.11 0.30 1470.67 1.00 135 48 14 1 FALSE 0.67
non-small cell lung cancer RAS_12C SMARCA4 Any mutation 137 225 Signature overall -0.11 -1.08 0.73 1415.62 1.00 1759 123 211 14 FALSE 0.09
non-small cell lung cancer RAS_12C PTPRT Any mutation 15 17 Signature 18 -0.82 -2.55 0.55 1377.63 1.00 120 14 16 1 FALSE 0.51
non-small cell lung cancer RAS_12C PTPRT Any mutation 22 30 Signature 2 -0.09 -1.41 1.05 1479.37 1.00 277 19 27 3 FALSE 0.05
non-small cell lung cancer RAS_12C PTPRT Any mutation 36 179 Signature 4 -0.43 -1.27 0.36 1581.06 1.00 537 29 172 7 FALSE 0.54
non-small cell lung cancer RAS_12C PTPRT Any mutation 49 23 Signature R2 -1.52 -2.96 -0.22 1535.01 1.00 132 48 22 1 FALSE 1.54
non-small cell lung cancer RAS_12C PTPRT Any mutation 133 290 Signature overall -0.82 -1.99 0.25 1420.83 1.00 1628 121 278 12 FALSE 0.82
non-small cell lung cancer RAS_12C HGF Any mutation 21 20 Signature 2 0.42 -1.05 1.79 1523.85 1.00 286 18 17 3 FALSE 0.24
non-small cell lung cancer RAS_12C HGF Any mutation 36 89 Signature 4 -0.31 -1.38 0.66 1664.93 1.00 590 32 85 4 FALSE 0.25
non-small cell lung cancer RAS_12C HGF Any mutation 49 12 Signature R2 -1.71 -4.68 0.01 1355.80 1.00 139 49 12 0 FALSE 0.81
non-small cell lung cancer RAS_12C HGF Any mutation 106 121 Signature overall -0.56 -2.41 1.04 1446.85 1.00 1015 99 114 7 FALSE 0.28
non-small cell lung cancer RAS_12C PIK3CA Any mutation 22 82 Signature 2 0.36 -0.47 1.19 1448.55 1.00 233 15 75 7 TRUE 0.40
non-small cell lung cancer RAS_12C PIK3CA Any mutation 36 38 Signature 4 0.27 -0.84 1.23 1449.80 1.00 632 33 35 3 TRUE 0.21
non-small cell lung cancer RAS_12C PIK3CA Any mutation 71 177 Signature overall 0.10 -1.06 1.15 1529.22 1.00 1482 60 166 11 TRUE 0.06
non-small cell lung cancer RAS_12C ALK Any mutation 21 24 Signature 2 0.41 -0.65 1.46 1344.04 1.00 284 18 21 3 TRUE 0.35
non-small cell lung cancer RAS_12C ALK Any mutation 36 72 Signature 4 0.21 -0.76 1.07 1465.94 1.00 603 32 68 4 TRUE 0.19
non-small cell lung cancer RAS_12C ALK Any mutation 57 96 Signature overall 0.30 -0.92 1.43 1606.54 1.00 887 50 89 7 TRUE 0.19
non-small cell lung cancer RAS_12C PTEN Any mutation 21 27 Signature 2 -5.25 -12.04 -0.89 1266.86 1.00 279 21 27 0 TRUE 1.14
non-small cell lung cancer RAS_12C PTEN Any mutation 36 27 Signature 4 -5.19 -11.79 -0.70 1152.01 1.00 640 36 27 0 TRUE 1.13
non-small cell lung cancer RAS_12C PTEN Any mutation 57 54 Signature overall -5.09 -11.52 -0.75 1307.46 1.00 919 57 54 0 TRUE 1.13
non-small cell lung cancer RAS_12C BCOR Any mutation 22 13 Signature 2 0.71 -0.48 1.86 1611.18 1.00 292 20 11 2 FALSE 0.64
non-small cell lung cancer RAS_12C BCOR Any mutation 37 52 Signature 4 0.69 -0.29 1.52 1363.58 1.00 625 32 47 5 FALSE 0.84
non-small cell lung cancer RAS_12C BCOR Any mutation 59 65 Signature overall 0.68 -0.72 1.87 1368.12 1.00 917 52 58 7 FALSE 0.54
non-small cell lung cancer RAS_12C CTNNB1 Any mutation 21 14 Signature 2 -1.63 -4.71 0.45 1632.29 1.00 289 21 14 0 TRUE 0.69
non-small cell lung cancer RAS_12C CTNNB1 Any mutation 36 16 Signature 4 -1.64 -4.80 0.56 1560.93 1.00 650 36 16 0 TRUE 0.67
non-small cell lung cancer RAS_12C CTNNB1 Any mutation 66 58 Signature overall -1.47 -4.28 0.53 1520.61 1.00 1412 65 57 1 TRUE 0.64
non-small cell lung cancer RAS_12C ARID1A Any mutation 15 12 Signature 18 -0.74 -2.57 0.70 1480.36 1.00 126 15 12 0 TRUE 0.42
non-small cell lung cancer RAS_12C ARID1A Any mutation 23 52 Signature 2 0.21 -0.79 1.08 1407.64 1.00 263 18 47 5 TRUE 0.18
non-small cell lung cancer RAS_12C ARID1A Any mutation 36 86 Signature 4 -0.18 -1.24 0.70 1273.60 1.00 587 32 82 4 TRUE 0.14
non-small cell lung cancer RAS_12C ARID1A Any mutation 49 13 Signature R2 -0.16 -1.30 0.89 1347.49 1.00 139 46 10 3 TRUE 0.11
non-small cell lung cancer RAS_12C ARID1A Any mutation 130 191 Signature overall -0.20 -1.26 0.79 1392.62 1.00 1424 117 178 13 TRUE 0.15
non-small cell lung cancer RAS_12C FAT1 Any mutation 15 16 Signature 18 0.30 -0.84 1.46 1485.21 1.00 122 12 13 3 FALSE 0.22
non-small cell lung cancer RAS_12C FAT1 Any mutation 21 38 Signature 2 -0.19 -1.41 0.85 1552.46 1.00 273 19 36 2 FALSE 0.13
non-small cell lung cancer RAS_12C FAT1 Any mutation 36 121 Signature 4 -0.36 -1.36 0.44 1378.37 1.00 563 32 117 4 FALSE 0.37
non-small cell lung cancer RAS_12C FAT1 Any mutation 85 228 Signature overall -0.14 -1.08 0.78 1595.89 1.00 1583 75 218 10 FALSE 0.11
non-small cell lung cancer RAS_12C NCOR1 Any mutation 21 11 Signature 2 0.28 -1.52 1.88 1350.93 1.00 297 19 9 2 FALSE 0.13
non-small cell lung cancer RAS_12C NCOR1 Any mutation 36 36 Signature 4 -0.46 -2.21 0.83 1451.13 1.00 633 35 35 1 FALSE 0.25
non-small cell lung cancer RAS_12C NCOR1 Any mutation 59 61 Signature overall -0.21 -2.18 1.44 1478.95 1.00 1016 56 58 3 FALSE 0.09
non-small cell lung cancer RAS_12C POLE Any mutation 21 19 Signature 2 0.58 -0.72 1.76 1526.88 1.00 289 18 16 3 TRUE 0.44
non-small cell lung cancer RAS_12C POLE Any mutation 36 49 Signature 4 0.10 -1.10 1.09 1576.51 1.00 623 33 46 3 TRUE 0.07
non-small cell lung cancer RAS_12C POLE Any mutation 49 11 Signature R2 -0.16 -1.51 0.99 1264.41 1.00 140 47 9 2 TRUE 0.10
non-small cell lung cancer RAS_12C POLE Any mutation 106 79 Signature overall 0.19 -1.11 1.43 1487.29 1.00 1052 98 71 8 TRUE 0.12
non-small cell lung cancer RAS_12C NOTCH2 Any mutation 21 15 Signature 2 -0.08 -1.74 1.46 1144.12 1.00 288 19 13 2 TRUE 0.04
non-small cell lung cancer RAS_12C NOTCH2 Any mutation 36 54 Signature 4 -0.65 -2.56 0.57 928.78 1.00 623 35 53 1 TRUE 0.39
non-small cell lung cancer RAS_12C NOTCH2 Any mutation 57 69 Signature overall -0.35 -2.20 1.34 1374.89 1.00 911 54 66 3 TRUE 0.17
non-small cell lung cancer RAS_12C KMT2A Any mutation 21 23 Signature 2 -0.78 -2.79 0.69 577.48 1.00 283 20 22 1 FALSE 0.44
non-small cell lung cancer RAS_12C KMT2A Any mutation 36 37 Signature 4 -0.83 -2.70 0.62 559.86 1.00 631 35 36 1 FALSE 0.47
non-small cell lung cancer RAS_12C KMT2A Any mutation 57 60 Signature overall -0.79 -2.80 0.74 560.02 1.00 914 55 58 2 FALSE 0.41
non-small cell lung cancer RAS_12C PAK7 Any mutation 36 69 Signature 4 -1.83 -4.54 0.06 1376.99 1.00 605 35 68 1 FALSE 0.91
non-small cell lung cancer RAS_12C PAK7 Any mutation 36 69 Signature overall -1.50 -6.19 3.77 1283.55 1.00 605 35 68 1 FALSE 0.27
non-small cell lung cancer RAS_12C STAG2 Any mutation 21 16 Signature 2 -1.03 -3.73 0.54 582.90 1.00 288 21 16 0 TRUE 0.42
non-small cell lung cancer RAS_12C STAG2 Any mutation 36 43 Signature 4 -0.70 -2.53 0.63 723.33 1.01 629 34 41 2 TRUE 0.40
non-small cell lung cancer RAS_12C STAG2 Any mutation 57 59 Signature overall -0.84 -2.99 0.66 573.36 1.00 917 55 57 2 TRUE 0.41
non-small cell lung cancer RAS_12C TERT Any mutation 21 23 Signature 2 0.24 -1.30 1.30 1269.36 1.00 282 20 22 1 TRUE 0.15
non-small cell lung cancer RAS_12C TERT Any mutation 37 54 Signature 4 0.56 -0.38 1.46 444.26 1.01 622 31 48 6 TRUE 0.62
non-small cell lung cancer RAS_12C TERT Any mutation 58 77 Signature overall 0.40 -1.04 1.51 980.64 1.00 904 51 70 7 TRUE 0.26
non-small cell lung cancer RAS_12C BRCA2 Any mutation 21 15 Signature 2 -1.40 -3.88 0.34 1349.82 1.00 289 21 15 0 TRUE 0.70
non-small cell lung cancer RAS_12C BRCA2 Any mutation 36 55 Signature 4 -0.98 -2.74 0.35 986.77 1.00 620 34 53 2 TRUE 0.64
non-small cell lung cancer RAS_12C BRCA2 Any mutation 59 83 Signature overall -1.22 -3.52 0.39 1120.54 1.00 994 57 81 2 TRUE 0.66
non-small cell lung cancer RAS_12C NOTCH3 Any mutation 15 11 Signature 18 0.66 -0.42 1.76 1347.09 1.00 128 12 8 3 TRUE 0.62
non-small cell lung cancer RAS_12C NOTCH3 Any mutation 21 15 Signature 2 0.53 -0.58 1.50 1244.46 1.00 291 19 13 2 TRUE 0.50
non-small cell lung cancer RAS_12C NOTCH3 Any mutation 36 48 Signature 4 0.30 -0.78 1.15 1078.74 1.00 625 34 46 2 TRUE 0.26
non-small cell lung cancer RAS_12C NOTCH3 Any mutation 72 74 Signature overall 0.50 -0.57 1.40 1289.77 1.00 1044 65 67 7 TRUE 0.50
non-small cell lung cancer RAS_12C NOTCH4 Any mutation 36 74 Signature 4 -0.39 -1.76 0.72 1098.97 1.00 601 33 71 3 TRUE 0.27
non-small cell lung cancer RAS_12C NOTCH4 Any mutation 36 74 Signature overall -0.38 -5.10 3.98 1434.05 1.00 601 33 71 3 TRUE 0.07
non-small cell lung cancer RAS_12C KEAP1 Any mutation 15 34 Signature 18 0.26 -0.69 1.14 1474.11 1.00 107 11 30 4 FALSE 0.23
non-small cell lung cancer RAS_12C KEAP1 Any mutation 21 55 Signature 2 0.31 -0.52 1.16 1481.95 1.00 256 16 50 5 FALSE 0.32
non-small cell lung cancer RAS_12C KEAP1 Any mutation 37 175 Signature 4 0.31 -0.36 0.96 1407.68 1.00 509 25 163 12 FALSE 0.45
non-small cell lung cancer RAS_12C KEAP1 Any mutation 50 45 Signature R2 0.14 -0.58 0.79 1444.79 1.00 116 39 34 11 FALSE 0.17
non-small cell lung cancer RAS_12C KEAP1 Any mutation 152 476 Signature overall 0.06 -0.54 0.65 1381.39 1.00 2018 116 440 36 FALSE 0.07
non-small cell lung cancer RAS_12C KDM5C Any mutation 21 15 Signature 2 -0.26 -3.76 1.28 742.96 1.00 289 21 15 0 FALSE 0.07
non-small cell lung cancer RAS_12C KDM5C Any mutation 37 41 Signature 4 0.56 -0.67 1.59 330.75 1.02 631 32 36 5 FALSE 0.47
non-small cell lung cancer RAS_12C KDM5C Any mutation 58 56 Signature overall 0.16 -2.34 1.67 816.58 1.01 920 53 51 5 FALSE 0.06
non-small cell lung cancer RAS_12C CDKN2A Any mutation 21 22 Signature 2 -1.43 -3.50 0.23 1413.60 1.00 282 21 22 0 TRUE 0.88
non-small cell lung cancer RAS_12C CDKN2A Any mutation 37 90 Signature 4 -0.55 -1.76 0.49 1370.71 1.00 587 33 86 4 TRUE 0.47
non-small cell lung cancer RAS_12C CDKN2A Any mutation 49 11 Signature R2 -0.80 -2.29 0.51 1533.10 1.00 140 47 9 2 TRUE 0.57
non-small cell lung cancer RAS_12C CDKN2A Any mutation 120 184 Signature overall -1.08 -2.51 0.20 1409.85 1.00 1679 114 178 6 TRUE 0.94
non-small cell lung cancer RAS_12C EPHB1 Any mutation 21 17 Signature 2 -0.18 -1.98 1.36 1280.27 1.00 289 19 15 2 FALSE 0.08
non-small cell lung cancer RAS_12C EPHB1 Any mutation 36 79 Signature 4 -1.11 -3.08 0.31 994.81 1.00 600 35 78 1 FALSE 0.69
non-small cell lung cancer RAS_12C EPHB1 Any mutation 57 96 Signature overall -0.63 -2.63 1.13 1190.57 1.00 889 54 93 3 FALSE 0.28
non-small cell lung cancer RAS_12C SMAD4 Any mutation 21 21 Signature 2 1.32 0.10 2.41 1413.37 1.00 287 16 16 5 TRUE 1.58
non-small cell lung cancer RAS_12C SMAD4 Any mutation 36 16 Signature 4 -0.65 -4.56 1.31 1569.12 1.00 650 36 16 0 TRUE 0.18
non-small cell lung cancer RAS_12C SMAD4 Any mutation 61 54 Signature overall 0.15 -2.47 1.88 1348.20 1.00 1184 56 49 5 TRUE 0.05
non-small cell lung cancer RAS_12C ATM Any mutation 15 11 Signature 18 0.09 -1.27 1.35 1362.91 1.00 126 14 10 1 TRUE 0.05
non-small cell lung cancer RAS_12C ATM Any mutation 21 27 Signature 2 -0.16 -1.55 0.99 1481.64 1.00 280 20 26 1 TRUE 0.10
non-small cell lung cancer RAS_12C ATM Any mutation 40 95 Signature 4 0.81 0.11 1.49 1534.41 1.00 595 29 84 11 TRUE 1.63
non-small cell lung cancer RAS_12C ATM Any mutation 50 25 Signature R2 0.26 -0.62 1.06 1399.01 1.00 131 43 18 7 TRUE 0.27
non-small cell lung cancer RAS_12C ATM Any mutation 134 195 Signature overall 0.27 -0.65 1.12 1591.57 1.00 1477 112 173 22 TRUE 0.26
non-small cell lung cancer RAS_12C RB1 Any mutation 15 11 Signature 18 -1.05 -2.67 0.28 997.76 1.00 125 14 10 1 TRUE 0.82
non-small cell lung cancer RAS_12C RB1 Any mutation 21 28 Signature 2 -1.08 -2.64 0.18 922.17 1.00 276 20 27 1 TRUE 0.88
non-small cell lung cancer RAS_12C RB1 Any mutation 36 67 Signature 4 -1.22 -2.71 -0.02 919.11 1.00 604 35 66 1 TRUE 1.11
non-small cell lung cancer RAS_12C RB1 Any mutation 83 151 Signature overall -1.15 -2.59 0.01 759.01 1.00 1558 80 148 3 TRUE 1.11
non-small cell lung cancer RAS_12C KMT2D Any mutation 15 16 Signature 18 -0.48 -2.15 0.78 1534.91 1.00 122 14 15 1 FALSE 0.29
non-small cell lung cancer RAS_12C KMT2D Any mutation 22 46 Signature 2 0.03 -1.07 1.01 1397.72 1.00 267 18 42 4 FALSE 0.02
non-small cell lung cancer RAS_12C KMT2D Any mutation 36 129 Signature 4 -0.38 -1.24 0.46 1477.30 1.00 565 31 124 5 FALSE 0.40
non-small cell lung cancer RAS_12C KMT2D Any mutation 49 13 Signature R2 -0.27 -1.44 0.86 1504.78 1.00 139 46 10 3 FALSE 0.19
non-small cell lung cancer RAS_12C KMT2D Any mutation 133 255 Signature overall -0.42 -1.49 0.53 1532.78 1.00 1642 120 242 13 FALSE 0.39
non-small cell lung cancer RAS_12C APC Any mutation 24 23 Signature 2 0.89 -0.34 2.02 1441.01 1.00 285 19 18 5 TRUE 0.86
non-small cell lung cancer RAS_12C APC Any mutation 36 50 Signature 4 -0.41 -2.22 0.81 1303.16 1.00 621 35 49 1 TRUE 0.23
non-small cell lung cancer RAS_12C APC Any mutation 64 86 Signature overall 0.12 -1.44 1.52 1443.64 1.00 1155 58 80 6 TRUE 0.06
non-small cell lung cancer RAS_12C ERBB2 Any mutation 21 12 Signature 2 -4.77 -11.51 -0.41 1437.75 1.00 291 21 12 0 TRUE 0.97
non-small cell lung cancer RAS_12C ERBB2 Any mutation 36 19 Signature 4 -4.82 -11.66 -0.53 1518.67 1.00 649 36 19 0 TRUE 0.99
non-small cell lung cancer RAS_12C ERBB2 Any mutation 61 46 Signature overall -4.72 -11.46 -0.31 1439.57 1.00 1187 61 46 0 TRUE 0.98
non-small cell lung cancer RAS_12C ARID2 Any mutation 15 11 Signature 18 -0.05 -1.30 1.04 1397.97 1.00 125 14 10 1 FALSE 0.03
non-small cell lung cancer RAS_12C ARID2 Any mutation 21 18 Signature 2 0.06 -1.25 1.24 1384.74 1.00 288 19 16 2 FALSE 0.04
non-small cell lung cancer RAS_12C ARID2 Any mutation 37 67 Signature 4 -0.25 -1.36 0.66 1373.87 1.00 609 35 65 2 FALSE 0.20
non-small cell lung cancer RAS_12C ARID2 Any mutation 78 112 Signature overall -0.04 -1.12 0.92 1393.63 1.00 1245 72 106 6 FALSE 0.03
non-small cell lung cancer RAS_12C MTOR Any mutation 36 41 Signature 4 0.26 -1.16 1.38 1177.19 1.00 628 33 38 3 TRUE 0.16
non-small cell lung cancer RAS_12C MTOR Any mutation 36 41 Signature overall 0.16 -4.32 4.42 1284.34 1.00 628 33 38 3 TRUE 0.03
non-small cell lung cancer RAS_12C NOTCH1 Any mutation 21 12 Signature 2 -1.42 -4.37 0.95 1076.99 1.01 292 20 11 1 TRUE 0.56
non-small cell lung cancer RAS_12C NOTCH1 Any mutation 36 54 Signature 4 -2.26 -5.79 -0.10 1336.30 1.00 615 36 54 0 TRUE 0.90
non-small cell lung cancer RAS_12C NOTCH1 Any mutation 57 66 Signature overall -1.80 -4.81 0.51 1483.00 1.00 907 56 65 1 TRUE 0.74
non-small cell lung cancer RAS_12C SETD2 Any mutation 22 44 Signature 2 0.26 -0.85 1.23 1376.40 1.00 275 18 40 4 FALSE 0.20
non-small cell lung cancer RAS_12C SETD2 Any mutation 6 15 Signature 3 0.78 -0.83 2.33 1431.60 1.00 226 4 13 2 FALSE 0.48
non-small cell lung cancer RAS_12C SETD2 Any mutation 36 55 Signature 4 -0.31 -1.59 0.76 1466.85 1.00 618 34 53 2 FALSE 0.22
non-small cell lung cancer RAS_12C SETD2 Any mutation 50 14 Signature R2 -0.17 -1.33 0.87 1485.36 1.00 139 47 11 3 FALSE 0.11
non-small cell lung cancer RAS_12C SETD2 Any mutation 116 144 Signature overall 0.05 -1.11 1.14 1536.32 1.00 1341 105 133 11 FALSE 0.03
non-small cell lung cancer RAS_12C PBRM1 Any mutation 21 20 Signature 2 -0.16 -1.77 1.11 888.74 1.00 289 20 19 1 TRUE 0.08
non-small cell lung cancer RAS_12C PBRM1 Any mutation 36 27 Signature 4 -0.03 -1.44 1.20 748.84 1.00 642 34 25 2 TRUE 0.02
non-small cell lung cancer RAS_12C PBRM1 Any mutation 57 47 Signature overall -0.11 -1.77 1.26 1203.37 1.00 931 54 44 3 TRUE 0.05
non-small cell lung cancer RAS_12C EPHA3 Any mutation 15 13 Signature 18 -1.18 -3.01 0.34 1548.70 1.00 123 15 13 0 FALSE 0.79
non-small cell lung cancer RAS_12C EPHA3 Any mutation 21 27 Signature 2 -0.85 -2.42 0.46 1477.97 1.00 280 20 26 1 FALSE 0.61
non-small cell lung cancer RAS_12C EPHA3 Any mutation 37 112 Signature 4 -0.85 -1.96 0.11 1285.83 1.00 567 34 109 3 FALSE 0.96
non-small cell lung cancer RAS_12C EPHA3 Any mutation 49 13 Signature R2 -0.76 -2.08 0.40 1438.86 1.00 139 47 11 2 FALSE 0.65
non-small cell lung cancer RAS_12C EPHA3 Any mutation 127 183 Signature overall -0.83 -2.00 0.25 1580.32 1.00 1332 120 176 7 FALSE 0.82
non-small cell lung cancer RAS_12C KDR Any mutation 21 12 Signature 2 0.42 -1.18 1.84 1616.67 1.00 293 19 10 2 TRUE 0.24
non-small cell lung cancer RAS_12C KDR Any mutation 37 76 Signature 4 0.04 -0.99 0.93 1322.77 1.00 599 33 72 4 TRUE 0.03
non-small cell lung cancer RAS_12C KDR Any mutation 63 99 Signature overall 0.10 -1.51 1.45 1535.63 1.00 1120 57 93 6 TRUE 0.05
non-small cell lung cancer RAS_12C TET1 Any mutation 21 12 Signature 2 0.63 -0.67 1.91 1463.28 1.00 291 19 10 2 FALSE 0.46
non-small cell lung cancer RAS_12C TET1 Any mutation 36 60 Signature 4 0.35 -0.73 1.31 1512.66 1.00 618 32 56 4 FALSE 0.30
non-small cell lung cancer RAS_12C TET1 Any mutation 57 72 Signature overall 0.47 -1.08 1.94 1464.79 1.00 909 51 66 6 FALSE 0.27
non-small cell lung cancer RAS_12C TBX3 Any mutation 36 75 Signature 4 -1.42 -3.39 -0.02 1323.24 1.00 600 35 74 1 FALSE 1.00
non-small cell lung cancer RAS_12C TBX3 Any mutation 49 15 Signature R2 -0.57 -2.04 0.61 1516.63 1.00 138 46 12 3 FALSE 0.40
non-small cell lung cancer RAS_12C TBX3 Any mutation 85 90 Signature overall -0.95 -3.27 1.49 1427.19 1.00 738 81 86 4 FALSE 0.38
non-small cell lung cancer RAS_12C NTRK3 Any mutation 21 15 Signature 2 0.52 -0.96 1.76 1417.31 1.00 292 19 13 2 FALSE 0.34
non-small cell lung cancer RAS_12C NTRK3 Any mutation 36 105 Signature 4 0.15 -0.69 0.92 1293.99 1.00 588 30 99 6 FALSE 0.15
non-small cell lung cancer RAS_12C NTRK3 Any mutation 49 18 Signature R2 0.27 -0.75 1.19 1420.00 1.00 137 44 13 5 FALSE 0.23
non-small cell lung cancer RAS_12C NTRK3 Any mutation 111 152 Signature overall 0.37 -0.79 1.59 1542.60 1.00 1243 97 138 14 FALSE 0.26
non-small cell lung cancer RAS_12C GRIN2A Any mutation 21 15 Signature 2 -0.99 -3.42 0.72 1613.41 1.00 288 21 15 0 FALSE 0.45
non-small cell lung cancer RAS_12C GRIN2A Any mutation 36 76 Signature 4 -0.43 -1.71 0.60 1364.65 1.00 601 33 73 3 FALSE 0.34
non-small cell lung cancer RAS_12C GRIN2A Any mutation 49 13 Signature R2 0.03 -1.12 1.15 1567.62 1.00 140 45 9 4 FALSE 0.02
non-small cell lung cancer RAS_12C GRIN2A Any mutation 106 104 Signature overall -0.46 -2.09 1.07 1498.76 1.00 1029 99 97 7 FALSE 0.25
non-small cell lung cancer RAS_12C STK11 Any mutation 15 38 Signature 18 0.23 -0.74 1.17 1506.84 1.00 103 11 34 4 TRUE 0.20
non-small cell lung cancer RAS_12C STK11 Any mutation 21 55 Signature 2 -0.24 -1.41 0.78 1411.66 1.00 259 19 53 2 TRUE 0.18
non-small cell lung cancer RAS_12C STK11 Any mutation 36 163 Signature 4 0.57 -0.09 1.22 1477.00 1.00 518 23 150 13 TRUE 1.03
non-small cell lung cancer RAS_12C STK11 Any mutation 50 61 Signature R2 0.05 -0.66 0.68 1640.69 1.00 102 36 47 14 TRUE 0.05
non-small cell lung cancer RAS_12C STK11 Any mutation 147 472 Signature overall 0.22 -0.45 0.88 1399.20 1.00 1874 106 431 41 TRUE 0.29
non-small cell lung cancer RAS_12C EP300 Any mutation 21 20 Signature 2 -1.81 -4.58 0.16 911.90 1.00 289 21 20 0 TRUE 0.86
non-small cell lung cancer RAS_12C EP300 Any mutation 36 30 Signature 4 -1.51 -3.89 0.40 984.21 1.00 638 35 29 1 TRUE 0.78
non-small cell lung cancer RAS_12C EP300 Any mutation 59 61 Signature overall -1.66 -4.24 0.14 1147.44 1.00 1014 58 60 1 TRUE 0.84
non-small cell lung cancer RAS_12C ERBB4 Any mutation 21 17 Signature 2 -1.14 -4.06 0.69 1513.87 1.00 289 21 17 0 TRUE 0.43
non-small cell lung cancer RAS_12C ERBB4 Any mutation 37 97 Signature 4 0.02 -1.01 0.90 1512.11 1.00 593 31 91 6 TRUE 0.01
non-small cell lung cancer RAS_12C ERBB4 Any mutation 62 125 Signature overall -0.65 -2.80 0.95 1475.17 1.00 1133 56 119 6 TRUE 0.28
non-small cell lung cancer RAS_12C MED12 Any mutation 21 25 Signature 2 -0.80 -2.41 0.47 1253.50 1.00 280 20 24 1 TRUE 0.57
non-small cell lung cancer RAS_12C MED12 Any mutation 36 72 Signature 4 -0.82 -2.26 0.32 1180.74 1.00 606 34 70 2 TRUE 0.68
non-small cell lung cancer RAS_12C MED12 Any mutation 57 97 Signature overall -0.81 -2.50 0.49 1261.79 1.00 886 54 94 3 TRUE 0.54
non-small cell lung cancer RAS_12C RBM10 Any mutation 16 17 Signature 18 0.94 -0.20 2.02 1457.44 1.00 123 11 12 5 FALSE 1.03
non-small cell lung cancer RAS_12C RBM10 Any mutation 21 32 Signature 2 -0.36 -1.74 0.81 1413.93 1.00 272 20 31 1 FALSE 0.24
non-small cell lung cancer RAS_12C RBM10 Any mutation 38 128 Signature 4 0.04 -0.78 0.74 1582.55 1.00 554 31 121 7 FALSE 0.03
non-small cell lung cancer RAS_12C RBM10 Any mutation 49 20 Signature R2 -0.15 -1.17 0.72 1088.85 1.00 133 45 16 4 FALSE 0.12
non-small cell lung cancer RAS_12C RBM10 Any mutation 139 285 Signature overall 0.03 -0.81 0.79 1518.40 1.00 1842 120 266 19 FALSE 0.02
non-small cell lung cancer RAS_12C NF1 Any mutation 15 13 Signature 18 -0.23 -1.79 1.11 1603.48 1.00 125 13 11 2 TRUE 0.12
non-small cell lung cancer RAS_12C NF1 Any mutation 23 39 Signature 2 0.26 -0.86 1.32 1465.38 1.00 272 18 34 5 TRUE 0.20
non-small cell lung cancer RAS_12C NF1 Any mutation 36 113 Signature 4 -1.38 -2.78 -0.25 1373.10 1.00 579 35 112 1 TRUE 1.48
non-small cell lung cancer RAS_12C NF1 Any mutation 49 12 Signature R2 -1.06 -2.59 0.16 1438.30 1.00 139 48 11 1 TRUE 0.88
non-small cell lung cancer RAS_12C NF1 Any mutation 138 229 Signature overall -0.75 -1.93 0.30 1329.71 1.00 1744 129 220 9 TRUE 0.76
non-small cell lung cancer RAS_12C FLT1 Any mutation 15 13 Signature 18 -1.04 -3.02 0.44 1379.01 1.00 123 15 13 0 FALSE 0.64
non-small cell lung cancer RAS_12C FLT1 Any mutation 21 12 Signature 2 -0.72 -2.33 0.87 1557.37 1.00 292 20 11 1 FALSE 0.42
non-small cell lung cancer RAS_12C FLT1 Any mutation 36 64 Signature 4 -0.81 -2.22 0.30 1416.17 1.00 614 34 62 2 FALSE 0.66
non-small cell lung cancer RAS_12C FLT1 Any mutation 72 89 Signature overall -0.86 -2.41 0.50 1499.20 1.00 1029 69 86 3 FALSE 0.61
non-small cell lung cancer RAS_12C EPHA5 Any mutation 15 24 Signature 18 -0.05 -1.35 1.06 1501.45 1.00 115 13 22 2 FALSE 0.03
non-small cell lung cancer RAS_12C EPHA5 Any mutation 21 30 Signature 2 0.52 -0.52 1.49 1281.62 1.00 280 17 26 4 FALSE 0.48
non-small cell lung cancer RAS_12C EPHA5 Any mutation 36 109 Signature 4 0.20 -0.67 0.97 1571.33 1.00 579 29 102 7 FALSE 0.21
non-small cell lung cancer RAS_12C EPHA5 Any mutation 49 12 Signature R2 -0.01 -1.12 1.04 1437.98 1.00 141 46 9 3 FALSE 0.01
non-small cell lung cancer RAS_12C EPHA5 Any mutation 126 194 Signature overall 0.08 -0.88 1.02 1541.57 1.00 1337 110 178 16 FALSE 0.06
non-small cell lung cancer RAS_12C AR Any mutation 36 56 Signature 4 -1.67 -4.33 0.17 813.37 1.01 618 35 55 1 TRUE 0.85
non-small cell lung cancer RAS_12C AR Any mutation 36 56 Signature overall -1.52 -5.73 3.12 929.88 1.01 618 35 55 1 TRUE 0.33
non-small cell lung cancer RAS_12C ROS1 Any mutation 21 14 Signature 2 -1.89 -4.88 0.20 745.72 1.00 290 21 14 0 TRUE 0.80
non-small cell lung cancer RAS_12C ROS1 Any mutation 36 42 Signature 4 -1.69 -4.53 0.23 706.89 1.00 627 35 41 1 TRUE 0.80
non-small cell lung cancer RAS_12C ROS1 Any mutation 57 56 Signature overall -1.78 -4.71 0.30 760.41 1.00 917 56 55 1 TRUE 0.78
non-small cell lung cancer RAS_12C PIK3CG Any mutation 22 18 Signature 2 0.31 -1.18 1.65 1237.18 1.00 289 19 15 3 FALSE 0.17
non-small cell lung cancer RAS_12C PIK3CG Any mutation 36 75 Signature 4 -0.79 -2.21 0.34 1459.91 1.00 600 34 73 2 FALSE 0.63
non-small cell lung cancer RAS_12C PIK3CG Any mutation 49 12 Signature R2 -1.03 -2.79 0.29 1481.77 1.00 139 48 11 1 FALSE 0.73
non-small cell lung cancer RAS_12C PIK3CG Any mutation 109 118 Signature overall -0.58 -2.05 0.81 1292.51 1.00 1112 103 112 6 FALSE 0.37
non-small cell lung cancer RAS_12C EGFR Any mutation 15 29 Signature 18 -2.95 -4.58 -1.57 1352.37 1.00 110 15 29 0 TRUE 3.97
non-small cell lung cancer RAS_12C EGFR Any mutation 21 79 Signature 2 -2.98 -4.52 -1.63 1360.29 1.00 240 21 79 0 TRUE 4.16
non-small cell lung cancer RAS_12C EGFR Any mutation 36 114 Signature 4 -2.56 -4.05 -1.28 1089.84 1.00 575 34 112 2 TRUE 3.48
non-small cell lung cancer RAS_12C EGFR Any mutation 112 853 Signature overall -2.90 -4.19 -1.84 1339.34 1.00 1889 109 850 3 TRUE 5.60
non-small cell lung cancer RAS_12C ARID1B Any mutation 21 13 Signature 2 -0.60 -2.55 0.97 1374.93 1.00 291 20 12 1 TRUE 0.30
non-small cell lung cancer RAS_12C ARID1B Any mutation 36 42 Signature 4 -0.76 -2.67 0.62 1153.47 1.00 627 35 41 1 TRUE 0.43
non-small cell lung cancer RAS_12C ARID1B Any mutation 57 55 Signature overall -0.67 -2.62 0.89 1211.83 1.00 918 55 53 2 TRUE 0.34
non-small cell lung cancer RAS_12C MET Any mutation 21 23 Signature 2 -1.05 -3.21 0.52 980.84 1.00 283 21 23 0 TRUE 0.57
non-small cell lung cancer RAS_12C MET Any mutation 36 34 Signature 4 -0.88 -2.80 0.58 543.02 1.00 637 35 33 1 TRUE 0.52
non-small cell lung cancer RAS_12C MET Any mutation 62 68 Signature overall -0.84 -2.67 0.60 548.64 1.00 1149 60 66 2 TRUE 0.49
non-small cell lung cancer RAS_12C BRAF Any mutation 15 11 Signature 18 -0.45 -1.97 0.74 1348.82 1.00 124 15 11 0 TRUE 0.29
non-small cell lung cancer RAS_12C BRAF Any mutation 21 20 Signature 2 -0.33 -1.56 0.76 1211.15 1.00 284 20 19 1 TRUE 0.23
non-small cell lung cancer RAS_12C BRAF Any mutation 36 50 Signature 4 -0.10 -1.09 0.90 785.01 1.01 622 32 46 4 TRUE 0.07
non-small cell lung cancer RAS_12C BRAF Any mutation 77 101 Signature overall -0.33 -1.59 0.68 1206.52 1.00 1248 72 96 5 TRUE 0.25
non-small cell lung cancer RAS_12C CARD11 Any mutation 22 16 Signature 2 0.62 -0.60 1.84 1187.33 1.00 291 19 13 3 FALSE 0.47
non-small cell lung cancer RAS_12C CARD11 Any mutation 36 63 Signature 4 0.10 -1.10 1.04 1348.14 1.00 610 33 60 3 FALSE 0.07
non-small cell lung cancer RAS_12C CARD11 Any mutation 58 79 Signature overall 0.38 -1.08 1.82 1278.33 1.00 901 52 73 6 FALSE 0.21
non-small cell lung cancer RAS_12C INPP4B Any mutation 22 15 Signature 2 1.26 0.12 2.45 1429.99 1.00 293 18 11 4 FALSE 1.50
non-small cell lung cancer RAS_12C INPP4B Any mutation 36 60 Signature 4 0.74 -0.31 1.58 1233.28 1.00 619 31 55 5 FALSE 0.93
non-small cell lung cancer RAS_12C INPP4B Any mutation 58 75 Signature overall 1.00 -0.44 2.34 1312.01 1.00 912 49 66 9 FALSE 0.83
non-small cell lung cancer RAS_12C NFE2L2 Any mutation 21 32 Signature 2 -0.64 -2.50 0.79 1435.40 1.00 280 19 30 2 FALSE 0.34
non-small cell lung cancer RAS_12C NFE2L2 Any mutation 36 20 Signature 4 -1.57 -4.57 0.38 1509.18 1.00 647 36 20 0 FALSE 0.65
non-small cell lung cancer RAS_12C NFE2L2 Any mutation 59 67 Signature overall -1.16 -3.62 0.77 1476.61 1.00 1011 57 65 2 FALSE 0.53
non-small cell lung cancer RAS_12C GLI1 Any mutation 35 44 Signature 4 0.07 -1.40 1.20 1461.95 1.00 561 32 41 3 FALSE 0.04
non-small cell lung cancer RAS_12C GLI1 Any mutation 35 44 Signature overall 0.04 -4.10 4.60 1344.63 1.00 561 32 41 3 FALSE 0.01
non-small cell lung cancer RAS_12C ZFHX3 Any mutation 19 18 Signature 2 -0.81 -2.63 0.81 1474.00 1.00 254 18 17 1 FALSE 0.46
non-small cell lung cancer RAS_12C ZFHX3 Any mutation 34 61 Signature 4 -1.20 -2.91 0.11 1481.82 1.00 544 33 60 1 FALSE 0.90
non-small cell lung cancer RAS_12C ZFHX3 Any mutation 44 14 Signature R2 -0.88 -2.37 0.44 1418.07 1.00 121 42 12 2 FALSE 0.66
non-small cell lung cancer RAS_12C ZFHX3 Any mutation 97 93 Signature overall -0.95 -2.61 0.47 1358.70 1.00 919 93 89 4 FALSE 0.68
non-small cell lung cancer RAS_12C MGA Any mutation 19 28 Signature 2 -0.46 -1.93 0.84 1450.32 1.00 255 18 27 1 FALSE 0.28
non-small cell lung cancer RAS_12C MGA Any mutation 34 79 Signature 4 0.20 -0.72 1.05 1562.43 1.00 534 28 73 6 FALSE 0.19
non-small cell lung cancer RAS_12C MGA Any mutation 44 13 Signature R2 -0.18 -1.45 0.88 1249.98 1.00 123 41 10 3 FALSE 0.12
non-small cell lung cancer RAS_12C MGA Any mutation 97 120 Signature overall -0.15 -1.51 1.10 1596.41 1.00 912 87 110 10 FALSE 0.08
non-small cell lung cancer RAS_12C AMER1 Any mutation 21 11 Signature 2 0.34 -1.38 1.76 1496.01 1.00 293 20 10 1 FALSE 0.17
non-small cell lung cancer RAS_12C AMER1 Any mutation 37 83 Signature 4 0.73 -0.08 1.50 1469.66 1.00 607 29 75 8 FALSE 1.11
non-small cell lung cancer RAS_12C AMER1 Any mutation 58 94 Signature overall 0.49 -1.55 2.23 1411.07 1.00 900 49 85 9 FALSE 0.21
non-small cell lung cancer RAS_12C EPHA7 Any mutation 34 51 Signature 4 0.28 -1.05 1.38 1223.23 1.00 554 31 48 3 FALSE 0.20
non-small cell lung cancer RAS_12C EPHA7 Any mutation 38 64 Signature overall 0.90 -1.30 3.37 1460.78 1.00 756 33 59 5 FALSE 0.38
non-small cell lung cancer KRAS_12C SPEN Any mutation 48 39 Signature 2 -3.19 -8.98 -0.58 1312.85 1.00 264 48 39 0 FALSE 0.84
non-small cell lung cancer KRAS_12C SPEN Any mutation 101 24 Signature 4 0.14 -1.08 1.17 1372.66 1.00 585 96 19 5 FALSE 0.09
non-small cell lung cancer KRAS_12C SPEN Any mutation 149 63 Signature overall -1.34 -5.26 1.81 1597.56 1.00 849 144 58 5 FALSE 0.37
non-small cell lung cancer KRAS_12C KMT2C Any mutation 6 22 Signature 13 0.10 -1.18 1.31 1497.92 1.00 74 4 20 2 FALSE 0.06
non-small cell lung cancer KRAS_12C KMT2C Any mutation 48 40 Signature 2 0.15 -0.63 0.87 1303.40 1.00 245 41 33 7 FALSE 0.15
non-small cell lung cancer KRAS_12C KMT2C Any mutation 11 13 Signature 3 -0.36 -2.07 1.01 1532.95 1.00 219 11 13 0 FALSE 0.19
non-small cell lung cancer KRAS_12C KMT2C Any mutation 100 76 Signature 4 -0.09 -0.79 0.56 1571.75 1.00 542 90 66 10 FALSE 0.10
non-small cell lung cancer KRAS_12C KMT2C Any mutation 165 151 Signature overall -0.04 -1.04 0.86 1355.85 1.00 1080 146 132 19 FALSE 0.03
non-small cell lung cancer KRAS_12C TP53 Any mutation 8 79 Signature 13 -0.80 -1.73 0.17 1311.38 1.00 28 3 74 5 TRUE 0.98
non-small cell lung cancer KRAS_12C TP53 Any mutation 7 87 Signature 15 -1.06 -2.06 -0.08 1291.14 1.00 49 4 84 3 TRUE 1.44
non-small cell lung cancer KRAS_12C TP53 Any mutation 6 39 Signature 16 -0.08 -1.09 0.96 1312.48 1.00 24 0 33 6 TRUE 0.05
non-small cell lung cancer KRAS_12C TP53 Any mutation 38 92 Signature 18 -0.48 -1.12 0.17 1527.75 1.00 45 19 73 19 TRUE 0.81
non-small cell lung cancer KRAS_12C TP53 Any mutation 8 31 Signature 19 -0.53 -1.58 0.46 1362.95 1.00 31 4 27 4 TRUE 0.52
non-small cell lung cancer KRAS_12C TP53 Any mutation 8 149 Signature 1A -0.65 -1.61 0.23 1513.68 1.00 121 3 144 5 TRUE 0.78
non-small cell lung cancer KRAS_12C TP53 Any mutation 50 223 Signature 2 -0.63 -1.16 -0.06 1424.88 1.00 100 24 197 26 TRUE 1.60
non-small cell lung cancer KRAS_12C TP53 Any mutation 6 46 Signature 20 -1.40 -2.46 -0.34 1420.66 1.00 26 5 45 1 TRUE 1.96
non-small cell lung cancer KRAS_12C TP53 Any mutation 11 161 Signature 3 -0.81 -1.66 0.06 1326.43 1.00 90 5 155 6 TRUE 1.17
non-small cell lung cancer KRAS_12C TP53 Any mutation 102 522 Signature 4 -1.17 -1.55 -0.76 1604.16 1.00 170 56 476 46 TRUE 8.04
non-small cell lung cancer KRAS_12C TP53 Any mutation 6 36 Signature 6 -1.14 -2.21 -0.12 1489.21 1.00 13 4 34 2 TRUE 1.47
non-small cell lung cancer KRAS_12C TP53 Any mutation 10 71 Signature 7 -1.02 -2.00 -0.13 1498.47 1.00 35 6 67 4 TRUE 1.44
non-small cell lung cancer KRAS_12C TP53 Any mutation 7 35 Signature 8 -1.40 -2.54 -0.32 1206.48 1.00 22 6 34 1 TRUE 1.91
non-small cell lung cancer KRAS_12C TP53 Any mutation 135 85 Signature R2 -1.05 -1.59 -0.54 1512.39 1.00 27 94 44 41 TRUE 4.12
non-small cell lung cancer KRAS_12C TP53 Any mutation 7 57 Signature U1 -1.39 -2.53 -0.35 1315.92 1.00 50 6 56 1 TRUE 1.89
non-small cell lung cancer KRAS_12C TP53 Any mutation 427 1927 Signature overall -1.00 -1.41 -0.58 1418.79 1.00 978 252 1752 175 TRUE 5.84
non-small cell lung cancer KRAS_12C ATRX Any mutation 39 12 Signature 18 0.54 -0.27 1.35 1411.71 1.00 105 34 7 5 TRUE 0.73
non-small cell lung cancer KRAS_12C ATRX Any mutation 48 28 Signature 2 0.54 -0.15 1.27 1482.73 1.00 258 41 21 7 TRUE 0.90
non-small cell lung cancer KRAS_12C ATRX Any mutation 103 88 Signature 4 0.39 -0.13 0.89 1313.19 1.00 543 87 72 16 TRUE 0.87
non-small cell lung cancer KRAS_12C ATRX Any mutation 190 128 Signature overall 0.50 -0.20 1.20 1338.06 1.00 906 162 100 28 TRUE 0.79
non-small cell lung cancer KRAS_12C ATR Any mutation 6 11 Signature 13 0.32 -0.83 1.74 1504.90 1.00 83 4 9 2 FALSE 0.21
non-small cell lung cancer KRAS_12C ATR Any mutation 48 16 Signature 2 0.08 -0.84 1.05 1301.79 1.00 263 45 13 3 FALSE 0.07
non-small cell lung cancer KRAS_12C ATR Any mutation 100 60 Signature 4 -0.10 -0.87 0.54 1511.63 1.00 551 93 53 7 FALSE 0.11
non-small cell lung cancer KRAS_12C ATR Any mutation 154 87 Signature overall 0.10 -0.84 1.15 1494.57 1.00 897 142 75 12 FALSE 0.07
non-small cell lung cancer KRAS_12C PDGFRA Any mutation 48 20 Signature 2 0.47 -0.42 1.23 770.85 1.00 260 44 16 4 TRUE 0.59
non-small cell lung cancer KRAS_12C PDGFRA Any mutation 102 70 Signature 4 0.59 0.00 1.14 844.02 1.00 552 86 54 16 TRUE 1.30
non-small cell lung cancer KRAS_12C PDGFRA Any mutation 150 90 Signature overall 0.53 -0.42 1.33 1302.13 1.00 812 130 70 20 TRUE 0.62
non-small cell lung cancer KRAS_12C FLT4 Any mutation 48 11 Signature 2 -0.76 -2.24 0.42 1323.59 1.00 266 47 10 1 TRUE 0.60
non-small cell lung cancer KRAS_12C FLT4 Any mutation 100 36 Signature 4 -0.74 -1.88 0.26 1272.36 1.00 571 97 33 3 TRUE 0.75
non-small cell lung cancer KRAS_12C FLT4 Any mutation 148 47 Signature overall -0.74 -2.12 0.46 1385.09 1.00 837 144 43 4 TRUE 0.56
non-small cell lung cancer KRAS_12C PTPRD Any mutation 40 22 Signature 18 0.66 -0.24 1.56 1531.08 1.00 100 31 13 9 FALSE 0.84
non-small cell lung cancer KRAS_12C PTPRD Any mutation 7 12 Signature 1A 0.34 -1.47 2.01 1534.67 1.00 248 6 11 1 FALSE 0.15
non-small cell lung cancer KRAS_12C PTPRD Any mutation 48 33 Signature 2 0.18 -0.74 1.02 1418.08 1.00 250 42 27 6 FALSE 0.15
non-small cell lung cancer KRAS_12C PTPRD Any mutation 6 12 Signature 20 -0.74 -2.78 0.83 1516.28 1.00 61 6 12 0 FALSE 0.37
non-small cell lung cancer KRAS_12C PTPRD Any mutation 11 18 Signature 3 0.48 -1.06 1.88 1507.44 1.00 216 9 16 2 FALSE 0.29
non-small cell lung cancer KRAS_12C PTPRD Any mutation 107 195 Signature 4 -0.34 -0.87 0.12 1371.54 1.00 467 85 173 22 FALSE 0.78
non-small cell lung cancer KRAS_12C PTPRD Any mutation 135 18 Signature R2 -0.21 -1.07 0.74 1447.90 1.00 58 124 7 11 FALSE 0.18
non-small cell lung cancer KRAS_12C PTPRD Any mutation 357 321 Signature overall -0.04 -0.97 0.92 1597.05 1.00 1432 306 270 51 FALSE 0.03
non-small cell lung cancer KRAS_12C PIK3C2G Any mutation 48 17 Signature 2 -0.72 -2.01 0.26 1402.12 1.00 259 47 16 1 FALSE 0.68
non-small cell lung cancer KRAS_12C PIK3C2G Any mutation 100 57 Signature 4 -0.54 -1.44 0.22 1113.25 1.00 555 94 51 6 FALSE 0.68
non-small cell lung cancer KRAS_12C PIK3C2G Any mutation 148 74 Signature overall -0.63 -1.80 0.38 1375.77 1.00 814 141 67 7 FALSE 0.58
non-small cell lung cancer KRAS_12C CREBBP Any mutation 7 12 Signature 1A 0.16 -1.31 1.56 1502.58 1.00 248 6 11 1 TRUE 0.08
non-small cell lung cancer KRAS_12C CREBBP Any mutation 48 15 Signature 2 -0.10 -1.42 1.01 1270.82 1.00 263 46 13 2 TRUE 0.06
non-small cell lung cancer KRAS_12C CREBBP Any mutation 11 11 Signature 3 -0.32 -2.06 1.05 1444.37 1.00 221 11 11 0 TRUE 0.16
non-small cell lung cancer KRAS_12C CREBBP Any mutation 100 44 Signature 4 0.09 -0.80 0.88 1631.23 1.00 570 93 37 7 TRUE 0.08
non-small cell lung cancer KRAS_12C CREBBP Any mutation 166 82 Signature overall -0.04 -1.26 1.00 1481.14 1.00 1302 156 72 10 TRUE 0.02
non-small cell lung cancer KRAS_12C DOT1L Any mutation 48 16 Signature 2 -0.07 -1.00 0.83 494.60 1.01 262 46 14 2 FALSE 0.06
non-small cell lung cancer KRAS_12C DOT1L Any mutation 100 38 Signature 4 -0.01 -0.80 0.76 321.20 1.01 571 94 32 6 FALSE 0.01
non-small cell lung cancer KRAS_12C DOT1L Any mutation 148 54 Signature overall -0.04 -1.02 0.80 386.98 1.01 833 140 46 8 FALSE 0.03
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 6 11 Signature 13 0.02 -1.72 1.42 1508.96 1.00 82 5 10 1 FALSE 0.01
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 38 14 Signature 18 0.35 -0.68 1.32 1483.31 1.00 104 33 9 5 FALSE 0.29
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 7 17 Signature 1A 0.14 -1.50 1.63 1453.61 1.00 245 6 16 1 FALSE 0.07
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 50 33 Signature 2 0.32 -0.52 1.14 1600.37 1.00 255 43 26 7 FALSE 0.35
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 11 16 Signature 3 -0.60 -2.35 0.92 1445.88 1.00 217 11 16 0 FALSE 0.33
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 100 104 Signature 4 -0.36 -1.02 0.25 1546.82 1.00 516 89 93 11 FALSE 0.58
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 9 15 Signature 7 -0.24 -1.88 1.17 1330.95 1.00 85 8 14 1 FALSE 0.12
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 134 15 Signature R2 -0.24 -1.15 0.63 1552.61 1.00 58 125 6 9 FALSE 0.22
non-small cell lung cancer KRAS_12C SMARCA4 Any mutation 355 225 Signature overall -0.09 -0.97 0.74 1486.96 1.00 1562 320 190 35 FALSE 0.08
non-small cell lung cancer KRAS_12C PTPRT Any mutation 6 11 Signature 13 -0.14 -1.98 1.52 1517.67 1.00 84 5 10 1 FALSE 0.06
non-small cell lung cancer KRAS_12C PTPRT Any mutation 38 17 Signature 18 -0.52 -1.72 0.60 1430.59 1.00 99 35 14 3 FALSE 0.42
non-small cell lung cancer KRAS_12C PTPRT Any mutation 7 11 Signature 1A -0.73 -2.92 1.09 1435.61 1.00 251 7 11 0 FALSE 0.32
non-small cell lung cancer KRAS_12C PTPRT Any mutation 49 30 Signature 2 0.19 -0.75 1.07 1464.57 1.00 253 43 24 6 FALSE 0.16
non-small cell lung cancer KRAS_12C PTPRT Any mutation 11 19 Signature 3 -0.33 -2.10 1.25 1516.98 1.00 216 10 18 1 FALSE 0.15
non-small cell lung cancer KRAS_12C PTPRT Any mutation 101 179 Signature 4 -0.38 -0.95 0.13 1567.92 1.00 484 82 160 19 FALSE 0.77
non-small cell lung cancer KRAS_12C PTPRT Any mutation 134 23 Signature R2 -0.88 -1.73 -0.10 1526.76 1.00 56 124 13 10 FALSE 1.47
non-small cell lung cancer KRAS_12C PTPRT Any mutation 346 290 Signature overall -0.41 -1.44 0.60 1494.12 1.00 1443 306 250 40 FALSE 0.37
non-small cell lung cancer KRAS_12C HGF Any mutation 48 20 Signature 2 0.70 -0.40 1.68 1423.45 1.00 262 42 14 6 FALSE 0.72
non-small cell lung cancer KRAS_12C HGF Any mutation 100 89 Signature 4 -0.58 -1.32 0.12 1560.65 1.00 530 92 81 8 FALSE 0.90
non-small cell lung cancer KRAS_12C HGF Any mutation 135 12 Signature R2 -0.95 -2.09 0.12 1492.30 1.00 58 130 7 5 FALSE 1.04
non-small cell lung cancer KRAS_12C HGF Any mutation 283 121 Signature overall -0.27 -1.80 1.35 1482.95 1.00 850 264 102 19 FALSE 0.13
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 6 13 Signature 13 0.48 -0.97 1.81 1581.89 1.00 82 4 11 2 TRUE 0.31
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 7 13 Signature 1A 0.20 -1.42 1.56 1439.65 1.00 248 6 12 1 TRUE 0.10
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 49 82 Signature 2 0.14 -0.56 0.75 1219.80 1.00 212 36 69 13 TRUE 0.17
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 6 16 Signature 20 -0.09 -1.52 1.19 1520.66 1.00 56 5 15 1 TRUE 0.05
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 11 15 Signature 3 -0.42 -2.10 0.92 1499.80 1.00 217 11 15 0 TRUE 0.23
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 100 38 Signature 4 -0.31 -1.27 0.51 1519.20 1.00 569 96 34 4 TRUE 0.30
non-small cell lung cancer KRAS_12C PIK3CA Any mutation 179 177 Signature overall 0.00 -1.00 0.86 1423.84 1.00 1384 158 156 21 TRUE 0.00
non-small cell lung cancer KRAS_12C ALK Any mutation 48 24 Signature 2 0.44 -0.22 1.09 993.25 1.00 259 43 19 5 TRUE 0.70
non-small cell lung cancer KRAS_12C ALK Any mutation 100 72 Signature 4 0.47 -0.04 1.04 689.28 1.00 550 85 57 15 TRUE 1.03
non-small cell lung cancer KRAS_12C ALK Any mutation 148 96 Signature overall 0.45 -0.26 1.15 1168.90 1.00 809 128 76 20 TRUE 0.68
non-small cell lung cancer KRAS_12C PTEN Any mutation 48 27 Signature 2 -0.31 -1.42 0.67 646.02 1.01 255 45 24 3 TRUE 0.24
non-small cell lung cancer KRAS_12C PTEN Any mutation 100 27 Signature 4 -0.19 -1.22 0.78 297.14 1.01 580 96 23 4 TRUE 0.14
non-small cell lung cancer KRAS_12C PTEN Any mutation 148 54 Signature overall -0.26 -1.65 1.14 620.03 1.01 835 141 47 7 TRUE 0.15
non-small cell lung cancer KRAS_12C BCOR Any mutation 49 13 Signature 2 0.26 -0.85 1.20 1437.33 1.00 265 47 11 2 FALSE 0.21
non-small cell lung cancer KRAS_12C BCOR Any mutation 103 52 Signature 4 0.52 -0.11 1.13 877.52 1.00 566 91 40 12 FALSE 0.97
non-small cell lung cancer KRAS_12C BCOR Any mutation 152 65 Signature overall 0.40 -0.82 1.47 1542.68 1.00 831 138 51 14 FALSE 0.31
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 7 11 Signature 1A -1.58 -4.11 0.57 1512.68 1.00 248 7 11 0 TRUE 0.73
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 48 14 Signature 2 -1.33 -3.46 0.38 1200.96 1.00 263 47 13 1 TRUE 0.80
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 11 17 Signature 3 -1.09 -3.30 0.78 1253.04 1.01 216 10 16 1 TRUE 0.51
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 100 16 Signature 4 -1.89 -4.30 -0.18 1535.32 1.00 586 100 16 0 TRUE 1.17
non-small cell lung cancer KRAS_12C CTNNB1 Any mutation 166 58 Signature overall -1.47 -3.59 0.13 1360.63 1.00 1313 164 56 2 TRUE 0.95
non-small cell lung cancer KRAS_12C ARID1A Any mutation 6 17 Signature 13 -0.89 -3.33 0.91 1551.42 1.00 77 6 17 0 TRUE 0.42
non-small cell lung cancer KRAS_12C ARID1A Any mutation 41 12 Signature 18 1.09 0.04 2.22 1520.87 1.00 107 34 5 7 TRUE 1.34
non-small cell lung cancer KRAS_12C ARID1A Any mutation 51 52 Signature 2 0.54 -0.11 1.25 1364.40 1.00 242 39 40 12 TRUE 0.91
non-small cell lung cancer KRAS_12C ARID1A Any mutation 11 11 Signature 3 0.21 -1.66 1.88 1586.84 1.00 222 10 10 1 TRUE 0.09
non-small cell lung cancer KRAS_12C ARID1A Any mutation 100 86 Signature 4 -0.97 -1.90 -0.16 1394.93 1.00 524 95 81 5 TRUE 1.51
non-small cell lung cancer KRAS_12C ARID1A Any mutation 134 13 Signature R2 0.04 -0.96 1.06 1401.28 1.00 60 125 4 9 TRUE 0.03
non-small cell lung cancer KRAS_12C ARID1A Any mutation 343 191 Signature overall 0.00 -1.10 1.11 1458.71 1.00 1232 309 157 34 TRUE 0.00
non-small cell lung cancer KRAS_12C FAT1 Any mutation 6 16 Signature 13 -0.30 -1.79 0.97 1142.29 1.00 78 6 16 0 FALSE 0.17
non-small cell lung cancer KRAS_12C FAT1 Any mutation 38 16 Signature 18 0.68 -0.27 1.57 1662.90 1.00 103 31 9 7 FALSE 0.85
non-small cell lung cancer KRAS_12C FAT1 Any mutation 7 13 Signature 1A 0.31 -1.09 1.72 1338.33 1.00 250 6 12 1 FALSE 0.18
non-small cell lung cancer KRAS_12C FAT1 Any mutation 50 38 Signature 2 0.53 -0.25 1.26 1414.01 1.00 251 41 29 9 FALSE 0.77
non-small cell lung cancer KRAS_12C FAT1 Any mutation 6 11 Signature 20 -0.23 -1.78 1.01 1343.62 1.00 61 6 11 0 FALSE 0.12
non-small cell lung cancer KRAS_12C FAT1 Any mutation 11 13 Signature 3 0.18 -1.19 1.46 1495.97 1.00 220 10 12 1 FALSE 0.10
non-small cell lung cancer KRAS_12C FAT1 Any mutation 102 121 Signature 4 0.02 -0.53 0.56 1488.04 1.00 510 85 104 17 FALSE 0.02
non-small cell lung cancer KRAS_12C FAT1 Any mutation 220 228 Signature overall 0.18 -0.68 0.96 1304.50 1.00 1473 185 193 35 FALSE 0.19
non-small cell lung cancer KRAS_12C NCOR1 Any mutation 6 14 Signature 13 0.04 -1.48 1.42 1478.59 1.00 83 5 13 1 FALSE 0.02
non-small cell lung cancer KRAS_12C NCOR1 Any mutation 48 11 Signature 2 0.31 -0.89 1.49 1544.86 1.00 271 45 8 3 FALSE 0.21
non-small cell lung cancer KRAS_12C NCOR1 Any mutation 101 36 Signature 4 -0.24 -1.23 0.65 1552.12 1.00 571 97 32 4 FALSE 0.21
non-small cell lung cancer KRAS_12C NCOR1 Any mutation 155 61 Signature overall 0.04 -1.15 1.18 1441.82 1.00 925 147 53 8 FALSE 0.02
non-small cell lung cancer KRAS_12C POLE Any mutation 49 19 Signature 2 0.60 -0.50 1.60 1321.04 1.00 263 44 14 5 TRUE 0.57
non-small cell lung cancer KRAS_12C POLE Any mutation 100 49 Signature 4 0.17 -0.62 0.86 1342.44 1.00 564 92 41 8 TRUE 0.19
non-small cell lung cancer KRAS_12C POLE Any mutation 134 11 Signature R2 0.27 -0.82 1.47 1413.38 1.00 61 126 3 8 TRUE 0.19
non-small cell lung cancer KRAS_12C POLE Any mutation 283 79 Signature overall 0.33 -1.14 1.67 1325.68 1.00 888 262 58 21 TRUE 0.19
non-small cell lung cancer KRAS_12C NOTCH2 Any mutation 48 15 Signature 2 -0.45 -1.57 0.59 1169.53 1.00 261 46 13 2 TRUE 0.39
non-small cell lung cancer KRAS_12C NOTCH2 Any mutation 100 54 Signature 4 -0.51 -1.47 0.32 992.88 1.00 563 95 49 5 TRUE 0.59
non-small cell lung cancer KRAS_12C NOTCH2 Any mutation 148 69 Signature overall -0.48 -1.62 0.62 1148.59 1.00 824 141 62 7 TRUE 0.39
non-small cell lung cancer KRAS_12C KMT2A Any mutation 48 23 Signature 2 0.12 -0.78 0.96 1314.99 1.00 260 43 18 5 FALSE 0.10
non-small cell lung cancer KRAS_12C KMT2A Any mutation 100 37 Signature 4 -0.10 -1.00 0.65 1171.29 1.00 570 96 33 4 FALSE 0.09
non-small cell lung cancer KRAS_12C KMT2A Any mutation 148 60 Signature overall 0.00 -0.97 0.88 1243.80 1.00 830 139 51 9 FALSE 0.00
non-small cell lung cancer KRAS_12C PAK7 Any mutation 100 69 Signature 4 -0.87 -1.92 -0.04 1533.80 1.00 545 95 64 5 FALSE 1.09
non-small cell lung cancer KRAS_12C PAK7 Any mutation 100 69 Signature overall -0.72 -5.22 3.73 1532.67 1.00 545 95 64 5 FALSE 0.14
non-small cell lung cancer KRAS_12C STAG2 Any mutation 48 16 Signature 2 0.12 -0.72 0.88 290.69 1.02 263 46 14 2 TRUE 0.12
non-small cell lung cancer KRAS_12C STAG2 Any mutation 100 43 Signature 4 0.23 -0.36 0.93 7.05 1.15 572 91 34 9 TRUE 0.29
non-small cell lung cancer KRAS_12C STAG2 Any mutation 148 59 Signature overall 0.17 -0.53 0.95 48.64 1.04 835 137 48 11 TRUE 0.17
non-small cell lung cancer KRAS_12C TERT Any mutation 49 23 Signature 2 0.81 0.11 1.61 672.65 1.00 261 41 15 8 TRUE 1.49
non-small cell lung cancer KRAS_12C TERT Any mutation 101 54 Signature 4 0.63 -0.01 1.23 478.68 1.00 563 90 43 11 TRUE 1.30
non-small cell lung cancer KRAS_12C TERT Any mutation 150 77 Signature overall 0.71 -0.08 1.51 668.28 1.00 824 131 58 19 TRUE 1.01
non-small cell lung cancer KRAS_12C BRCA2 Any mutation 6 13 Signature 13 -0.72 -2.62 0.56 1242.27 1.00 81 6 13 0 TRUE 0.42
non-small cell lung cancer KRAS_12C BRCA2 Any mutation 48 15 Signature 2 -0.68 -2.17 0.43 1345.18 1.00 263 47 14 1 TRUE 0.51
non-small cell lung cancer KRAS_12C BRCA2 Any mutation 100 55 Signature 4 -0.19 -1.02 0.53 1246.84 1.00 562 92 47 8 TRUE 0.20
non-small cell lung cancer KRAS_12C BRCA2 Any mutation 154 83 Signature overall -0.53 -1.85 0.58 1365.97 1.00 906 145 74 9 TRUE 0.41
non-small cell lung cancer KRAS_12C NOTCH3 Any mutation 38 11 Signature 18 0.09 -0.84 1.07 1536.15 1.00 106 34 7 4 TRUE 0.07
non-small cell lung cancer KRAS_12C NOTCH3 Any mutation 48 15 Signature 2 -0.13 -1.13 0.78 1684.17 1.00 264 46 13 2 TRUE 0.11
non-small cell lung cancer KRAS_12C NOTCH3 Any mutation 100 48 Signature 4 -0.20 -1.02 0.52 1449.59 1.00 564 95 43 5 TRUE 0.22
non-small cell lung cancer KRAS_12C NOTCH3 Any mutation 186 74 Signature overall -0.09 -0.97 0.71 1627.62 1.00 934 175 63 11 TRUE 0.08
non-small cell lung cancer KRAS_12C NOTCH4 Any mutation 100 74 Signature 4 -0.55 -1.43 0.24 1206.82 1.00 541 93 67 7 TRUE 0.69
non-small cell lung cancer KRAS_12C NOTCH4 Any mutation 100 74 Signature overall -0.39 -4.80 3.94 1546.37 1.00 541 93 67 7 TRUE 0.07
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 6 20 Signature 13 0.21 -0.98 1.35 1668.71 1.00 74 4 18 2 FALSE 0.14
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 7 16 Signature 15 -0.42 -1.94 0.85 1441.96 1.00 114 7 16 0 FALSE 0.26
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 39 34 Signature 18 0.27 -0.48 1.00 1385.61 1.00 89 29 24 10 FALSE 0.32
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 9 11 Signature 19 0.51 -0.67 1.60 1722.99 1.00 46 6 8 3 FALSE 0.43
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 7 27 Signature 1A 0.36 -0.90 1.58 1520.90 1.00 236 5 25 2 FALSE 0.25
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 48 55 Signature 2 -0.15 -0.91 0.60 1491.53 1.00 231 41 48 7 FALSE 0.15
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 6 13 Signature 20 -0.04 -1.37 1.17 1484.12 1.00 59 5 12 1 FALSE 0.02
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 11 31 Signature 3 0.12 -1.07 1.24 1446.27 1.00 203 9 29 2 FALSE 0.07
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 101 175 Signature 4 0.17 -0.31 0.60 1553.97 1.00 461 73 147 28 FALSE 0.34
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 9 14 Signature 7 -0.09 -1.43 1.12 1484.80 1.00 87 8 13 1 FALSE 0.05
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 135 45 Signature R2 0.04 -0.56 0.63 1514.28 1.00 49 106 16 29 FALSE 0.05
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 7 11 Signature U1 0.43 -0.86 1.70 1475.64 1.00 95 5 9 2 FALSE 0.30
non-small cell lung cancer KRAS_12C KEAP1 Any mutation 393 476 Signature overall 0.04 -0.52 0.62 1469.60 1.00 1828 306 389 87 FALSE 0.05
non-small cell lung cancer KRAS_12C KDM5C Any mutation 48 15 Signature 2 -1.12 -5.55 0.64 351.03 1.01 262 48 15 0 FALSE 0.31
non-small cell lung cancer KRAS_12C KDM5C Any mutation 101 41 Signature 4 0.58 -0.18 1.34 147.47 1.02 573 90 30 11 FALSE 0.78
non-small cell lung cancer KRAS_12C KDM5C Any mutation 149 56 Signature overall -0.24 -3.17 1.39 1211.45 1.00 835 138 45 11 FALSE 0.08
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 6 12 Signature 13 -1.42 -3.86 0.50 1370.96 1.00 80 6 12 0 TRUE 0.69
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 7 11 Signature 15 -1.40 -3.73 0.53 1445.02 1.00 118 7 11 0 TRUE 0.70
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 7 18 Signature 1A -1.38 -3.88 0.61 1568.55 1.00 241 7 18 0 TRUE 0.64
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 48 22 Signature 2 -1.33 -3.08 0.06 1575.70 1.00 256 47 21 1 TRUE 1.00
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 11 20 Signature 3 -1.47 -3.81 0.45 1489.12 1.00 213 11 20 0 TRUE 0.75
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 102 90 Signature 4 -0.43 -1.13 0.22 1449.84 1.00 528 92 80 10 TRUE 0.67
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 134 11 Signature R2 -0.13 -1.21 0.97 1566.76 1.00 61 126 3 8 TRUE 0.09
non-small cell lung cancer KRAS_12C CDKN2A Any mutation 315 184 Signature overall -1.08 -2.49 0.08 1473.98 1.00 1497 296 165 19 TRUE 1.02
non-small cell lung cancer KRAS_12C EPHB1 Any mutation 48 17 Signature 2 -0.22 -1.36 0.87 1330.14 1.00 263 45 14 3 FALSE 0.16
non-small cell lung cancer KRAS_12C EPHB1 Any mutation 101 79 Signature 4 -0.51 -1.38 0.17 545.94 1.00 541 94 72 7 FALSE 0.69
non-small cell lung cancer KRAS_12C EPHB1 Any mutation 149 96 Signature overall -0.36 -1.71 1.02 1254.33 1.00 804 139 86 10 FALSE 0.22
non-small cell lung cancer KRAS_12C SMAD4 Any mutation 7 17 Signature 1A -0.52 -3.06 1.34 1336.26 1.00 244 7 17 0 TRUE 0.18
non-small cell lung cancer KRAS_12C SMAD4 Any mutation 48 21 Signature 2 0.71 -0.31 1.71 1462.71 1.00 261 42 15 6 TRUE 0.79
non-small cell lung cancer KRAS_12C SMAD4 Any mutation 100 16 Signature 4 -0.20 -1.69 0.98 1547.66 1.00 588 98 14 2 TRUE 0.11
non-small cell lung cancer KRAS_12C SMAD4 Any mutation 155 54 Signature overall 0.02 -1.72 1.54 1288.18 1.00 1093 147 46 8 TRUE 0.01
non-small cell lung cancer KRAS_12C ATM Any mutation 6 12 Signature 13 0.33 -1.29 1.74 1351.38 1.00 81 5 11 1 TRUE 0.18
non-small cell lung cancer KRAS_12C ATM Any mutation 38 11 Signature 18 0.51 -0.64 1.60 1309.56 1.00 106 34 7 4 TRUE 0.44
non-small cell lung cancer KRAS_12C ATM Any mutation 49 27 Signature 2 0.66 -0.22 1.48 1454.28 1.00 258 42 20 7 TRUE 0.89
non-small cell lung cancer KRAS_12C ATM Any mutation 11 13 Signature 3 0.87 -0.52 2.12 1598.30 1.00 221 9 11 2 TRUE 0.69
non-small cell lung cancer KRAS_12C ATM Any mutation 107 95 Signature 4 0.70 0.22 1.20 1598.08 1.00 540 84 72 23 TRUE 2.25
non-small cell lung cancer KRAS_12C ATM Any mutation 135 25 Signature R2 0.37 -0.44 1.16 1554.38 1.00 57 117 7 18 TRUE 0.43
non-small cell lung cancer KRAS_12C ATM Any mutation 349 195 Signature overall 0.54 -0.32 1.39 1338.75 1.00 1296 293 139 56 TRUE 0.63
non-small cell lung cancer KRAS_12C RB1 Any mutation 6 11 Signature 13 -1.24 -3.00 0.28 1397.88 1.00 83 6 11 0 TRUE 0.86
non-small cell lung cancer KRAS_12C RB1 Any mutation 38 11 Signature 18 -0.57 -1.78 0.57 1448.85 1.00 104 35 8 3 TRUE 0.47
non-small cell lung cancer KRAS_12C RB1 Any mutation 7 16 Signature 1A -1.21 -3.00 0.31 1643.36 1.00 243 7 16 0 TRUE 0.81
non-small cell lung cancer KRAS_12C RB1 Any mutation 48 28 Signature 2 -1.33 -2.77 -0.15 1605.16 1.00 249 47 27 1 TRUE 1.37
non-small cell lung cancer KRAS_12C RB1 Any mutation 11 18 Signature 3 -1.26 -3.00 0.26 1519.13 1.00 214 11 18 0 TRUE 0.94
non-small cell lung cancer KRAS_12C RB1 Any mutation 100 67 Signature 4 -0.92 -1.82 -0.06 1529.30 1.00 544 95 62 5 TRUE 1.39
non-small cell lung cancer KRAS_12C RB1 Any mutation 210 151 Signature overall -1.08 -2.18 -0.10 1534.71 1.00 1437 201 142 9 TRUE 1.39
non-small cell lung cancer KRAS_12C KMT2D Any mutation 6 16 Signature 13 -1.24 -3.47 0.59 1649.98 1.00 77 6 16 0 FALSE 0.62
non-small cell lung cancer KRAS_12C KMT2D Any mutation 38 16 Signature 18 -0.87 -2.23 0.28 1599.12 1.00 100 36 14 2 FALSE 0.73
non-small cell lung cancer KRAS_12C KMT2D Any mutation 7 22 Signature 1A -1.05 -3.26 0.76 1406.98 1.00 240 7 22 0 FALSE 0.51
non-small cell lung cancer KRAS_12C KMT2D Any mutation 49 46 Signature 2 0.10 -0.75 0.89 1445.34 1.00 244 41 38 8 FALSE 0.09
non-small cell lung cancer KRAS_12C KMT2D Any mutation 11 13 Signature 3 -1.05 -3.24 0.74 1460.10 1.00 219 11 13 0 FALSE 0.51
non-small cell lung cancer KRAS_12C KMT2D Any mutation 101 129 Signature 4 -0.13 -0.70 0.39 1502.22 1.00 512 84 112 17 FALSE 0.19
non-small cell lung cancer KRAS_12C KMT2D Any mutation 134 13 Signature R2 -0.12 -1.14 0.92 1325.17 1.00 60 125 4 9 FALSE 0.09
non-small cell lung cancer KRAS_12C KMT2D Any mutation 346 255 Signature overall -0.60 -1.80 0.47 1554.90 1.00 1452 310 219 36 FALSE 0.54
non-small cell lung cancer KRAS_12C APC Any mutation 7 13 Signature 1A -0.65 -3.35 1.23 1513.29 1.00 246 7 13 0 TRUE 0.23
non-small cell lung cancer KRAS_12C APC Any mutation 51 23 Signature 2 0.44 -0.62 1.38 1480.71 1.00 259 45 17 6 TRUE 0.41
non-small cell lung cancer KRAS_12C APC Any mutation 100 50 Signature 4 -0.59 -1.64 0.32 1597.21 1.00 560 96 46 4 TRUE 0.62
non-small cell lung cancer KRAS_12C APC Any mutation 158 86 Signature overall -0.25 -2.06 1.18 1482.81 1.00 1065 148 76 10 TRUE 0.12
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 7 15 Signature 1A -2.58 -6.45 0.25 1185.78 1.00 244 7 15 0 TRUE 0.92
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 48 12 Signature 2 -2.73 -6.32 -0.44 1319.07 1.00 264 48 12 0 TRUE 1.08
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 100 19 Signature 4 -2.14 -4.99 -0.17 1416.75 1.00 586 99 18 1 TRUE 1.07
non-small cell lung cancer KRAS_12C ERBB2 Any mutation 155 46 Signature overall -2.46 -5.61 -0.15 1315.29 1.00 1094 154 45 1 TRUE 1.12
non-small cell lung cancer KRAS_12C ARID2 Any mutation 38 11 Signature 18 0.03 -1.12 1.04 1513.40 1.00 104 35 8 3 FALSE 0.02
non-small cell lung cancer KRAS_12C ARID2 Any mutation 48 18 Signature 2 0.18 -0.83 1.11 1448.55 1.00 263 44 14 4 FALSE 0.15
non-small cell lung cancer KRAS_12C ARID2 Any mutation 11 16 Signature 3 -0.02 -1.29 1.25 1553.73 1.00 217 10 15 1 FALSE 0.01
non-small cell lung cancer KRAS_12C ARID2 Any mutation 101 67 Signature 4 -0.28 -1.02 0.40 1521.49 1.00 550 94 60 7 FALSE 0.36
non-small cell lung cancer KRAS_12C ARID2 Any mutation 198 112 Signature overall -0.03 -0.98 0.86 1441.44 1.00 1134 183 97 15 FALSE 0.02
non-small cell lung cancer KRAS_12C MTOR Any mutation 100 41 Signature 4 0.53 -0.32 1.24 1027.22 1.00 570 91 32 9 TRUE 0.75
non-small cell lung cancer KRAS_12C MTOR Any mutation 100 41 Signature overall 0.51 -3.83 4.86 1401.13 1.00 570 91 32 9 TRUE 0.10
non-small cell lung cancer KRAS_12C NOTCH1 Any mutation 48 12 Signature 2 -1.09 -2.74 0.24 1253.12 1.00 265 47 11 1 TRUE 0.84
non-small cell lung cancer KRAS_12C NOTCH1 Any mutation 100 54 Signature 4 -1.14 -2.33 -0.11 1057.69 1.00 554 97 51 3 TRUE 1.34
non-small cell lung cancer KRAS_12C NOTCH1 Any mutation 148 66 Signature overall -1.09 -2.63 0.29 1241.26 1.00 819 144 62 4 TRUE 0.84
non-small cell lung cancer KRAS_12C SETD2 Any mutation 7 16 Signature 13 0.42 -1.10 1.82 1381.67 1.00 80 5 14 2 FALSE 0.25
non-small cell lung cancer KRAS_12C SETD2 Any mutation 50 44 Signature 2 0.41 -0.37 1.17 1601.01 1.00 252 41 35 9 FALSE 0.53
non-small cell lung cancer KRAS_12C SETD2 Any mutation 12 15 Signature 3 0.61 -0.88 1.94 1498.67 1.00 220 10 13 2 FALSE 0.39
non-small cell lung cancer KRAS_12C SETD2 Any mutation 100 55 Signature 4 0.01 -0.79 0.72 1379.71 1.00 560 92 47 8 FALSE 0.01
non-small cell lung cancer KRAS_12C SETD2 Any mutation 135 14 Signature R2 -0.51 -1.51 0.50 1460.71 1.00 58 128 7 7 FALSE 0.49
non-small cell lung cancer KRAS_12C SETD2 Any mutation 304 144 Signature overall 0.18 -0.96 1.36 1217.84 1.00 1170 276 116 28 FALSE 0.13
non-small cell lung cancer KRAS_12C PBRM1 Any mutation 48 20 Signature 2 0.02 -1.05 0.85 461.85 1.01 264 45 17 3 TRUE 0.02
non-small cell lung cancer KRAS_12C PBRM1 Any mutation 100 27 Signature 4 0.00 -1.01 0.76 419.15 1.01 580 96 23 4 TRUE 0.00
non-small cell lung cancer KRAS_12C PBRM1 Any mutation 148 47 Signature overall 0.03 -1.19 0.98 456.50 1.01 844 141 40 7 TRUE 0.02
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 38 13 Signature 18 -0.44 -1.72 0.69 1685.58 1.00 102 36 11 2 FALSE 0.31
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 50 27 Signature 2 0.56 -0.36 1.43 1525.83 1.00 257 43 20 7 FALSE 0.68
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 11 18 Signature 3 0.47 -0.92 1.78 1527.17 1.00 218 9 16 2 FALSE 0.30
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 103 112 Signature 4 -0.11 -0.67 0.45 1496.86 1.00 513 88 97 15 FALSE 0.15
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 135 13 Signature R2 -0.20 -1.16 0.80 1652.70 1.00 59 127 5 8 FALSE 0.16
non-small cell lung cancer KRAS_12C EPHA3 Any mutation 337 183 Signature overall 0.06 -0.95 1.15 1115.91 1.00 1149 303 149 34 FALSE 0.04
non-small cell lung cancer KRAS_12C KDR Any mutation 48 12 Signature 2 0.62 -0.60 1.79 1503.30 1.00 268 44 8 4 TRUE 0.51
non-small cell lung cancer KRAS_12C KDR Any mutation 11 11 Signature 3 0.23 -1.50 1.74 1433.04 1.00 223 10 10 1 TRUE 0.10
non-small cell lung cancer KRAS_12C KDR Any mutation 101 76 Signature 4 -0.42 -1.23 0.26 1608.54 1.00 538 94 69 7 TRUE 0.55
non-small cell lung cancer KRAS_12C KDR Any mutation 160 99 Signature overall 0.16 -1.26 1.65 1490.69 1.00 1029 148 87 12 TRUE 0.09
non-small cell lung cancer KRAS_12C TET1 Any mutation 48 12 Signature 2 0.91 -0.44 2.14 652.23 1.00 267 43 7 5 FALSE 0.79
non-small cell lung cancer KRAS_12C TET1 Any mutation 101 60 Signature 4 -0.13 -0.93 0.61 565.52 1.01 556 94 53 7 FALSE 0.12
non-small cell lung cancer KRAS_12C TET1 Any mutation 149 72 Signature overall 0.38 -1.29 2.11 1409.76 1.00 823 137 60 12 FALSE 0.19
non-small cell lung cancer KRAS_12C TBX3 Any mutation 100 75 Signature 4 -0.75 -1.68 0.08 1566.81 1.00 541 94 69 6 FALSE 1.04
non-small cell lung cancer KRAS_12C TBX3 Any mutation 134 15 Signature R2 -0.08 -1.06 1.08 1391.08 1.00 60 124 5 10 FALSE 0.05
non-small cell lung cancer KRAS_12C TBX3 Any mutation 234 90 Signature overall -0.42 -2.59 2.00 1362.15 1.00 601 218 74 16 FALSE 0.15
non-small cell lung cancer KRAS_12C NTRK3 Any mutation 49 15 Signature 2 1.54 0.50 2.58 1554.48 1.00 269 42 8 7 FALSE 2.44
non-small cell lung cancer KRAS_12C NTRK3 Any mutation 11 14 Signature 3 1.57 0.08 2.95 1352.01 1.00 222 8 11 3 FALSE 1.54
non-small cell lung cancer KRAS_12C NTRK3 Any mutation 102 105 Signature 4 0.15 -0.43 0.68 1423.58 1.00 532 86 89 16 FALSE 0.21
non-small cell lung cancer KRAS_12C NTRK3 Any mutation 135 18 Signature R2 1.00 -0.06 2.09 1441.03 1.00 61 120 3 15 FALSE 1.16
non-small cell lung cancer KRAS_12C NTRK3 Any mutation 297 152 Signature overall 1.05 -0.33 2.45 1592.81 1.00 1084 256 111 41 FALSE 0.87
non-small cell lung cancer KRAS_12C GRIN2A Any mutation 48 15 Signature 2 -0.96 -2.79 0.49 1622.89 1.00 262 47 14 1 FALSE 0.62
non-small cell lung cancer KRAS_12C GRIN2A Any mutation 102 76 Signature 4 -0.49 -1.25 0.20 1385.63 1.00 540 94 68 8 FALSE 0.73
non-small cell lung cancer KRAS_12C GRIN2A Any mutation 134 13 Signature R2 -0.60 -1.61 0.41 1368.59 1.00 58 127 6 7 FALSE 0.60
non-small cell lung cancer KRAS_12C GRIN2A Any mutation 284 104 Signature overall -0.64 -2.18 0.92 1460.57 1.00 860 268 88 16 FALSE 0.38
non-small cell lung cancer KRAS_12C STK11 Any mutation 7 19 Signature 15 0.75 -0.56 1.98 1526.94 1.00 112 5 17 2 TRUE 0.62
non-small cell lung cancer KRAS_12C STK11 Any mutation 39 38 Signature 18 0.41 -0.32 1.13 1665.87 1.00 86 28 27 11 TRUE 0.57
non-small cell lung cancer KRAS_12C STK11 Any mutation 8 17 Signature 19 0.70 -0.44 1.86 1300.29 1.00 41 5 14 3 TRUE 0.62
non-small cell lung cancer KRAS_12C STK11 Any mutation 7 21 Signature 1A 1.68 0.49 2.82 1463.79 1.00 242 3 17 4 TRUE 2.20
non-small cell lung cancer KRAS_12C STK11 Any mutation 48 55 Signature 2 -0.30 -1.16 0.48 1385.59 1.00 235 43 50 5 TRUE 0.32
non-small cell lung cancer KRAS_12C STK11 Any mutation 6 13 Signature 20 1.22 0.03 2.42 1451.83 1.00 61 3 10 3 TRUE 1.29
non-small cell lung cancer KRAS_12C STK11 Any mutation 11 37 Signature 3 0.95 -0.12 2.02 1209.03 1.00 199 7 33 4 TRUE 1.12
non-small cell lung cancer KRAS_12C STK11 Any mutation 100 163 Signature 4 0.30 -0.14 0.76 1540.27 1.00 468 73 136 27 TRUE 0.73
non-small cell lung cancer KRAS_12C STK11 Any mutation 7 13 Signature 8 1.40 0.21 2.59 1409.55 1.00 48 3 9 4 TRUE 1.67
non-small cell lung cancer KRAS_12C STK11 Any mutation 135 61 Signature R2 0.72 0.09 1.36 1303.50 1.00 49 89 15 46 TRUE 1.58
non-small cell lung cancer KRAS_12C STK11 Any mutation 7 13 Signature U1 1.22 -0.06 2.42 1670.53 1.00 94 4 10 3 TRUE 1.33
non-small cell lung cancer KRAS_12C STK11 Any mutation 382 472 Signature overall 0.81 0.22 1.42 1466.20 1.00 1713 267 357 115 TRUE 2.04
non-small cell lung cancer KRAS_12C EP300 Any mutation 6 11 Signature 13 -0.37 -2.06 1.22 1238.87 1.00 84 5 10 1 TRUE 0.19
non-small cell lung cancer KRAS_12C EP300 Any mutation 48 20 Signature 2 -1.17 -3.25 0.18 1426.48 1.00 262 48 20 0 TRUE 0.61
non-small cell lung cancer KRAS_12C EP300 Any mutation 100 30 Signature 4 -0.21 -1.38 0.78 1259.02 1.00 578 95 25 5 TRUE 0.16
non-small cell lung cancer KRAS_12C EP300 Any mutation 154 61 Signature overall -0.57 -2.17 0.68 1430.55 1.00 924 148 55 6 TRUE 0.40
non-small cell lung cancer KRAS_12C ERBB4 Any mutation 7 11 Signature 1A -1.82 -5.48 0.68 1376.76 1.00 248 7 11 0 TRUE 0.60
non-small cell lung cancer KRAS_12C ERBB4 Any mutation 48 17 Signature 2 -2.35 -6.08 -0.30 1488.85 1.00 262 48 17 0 TRUE 0.96
non-small cell lung cancer KRAS_12C ERBB4 Any mutation 101 97 Signature 4 -0.81 -1.64 -0.09 1425.85 1.00 531 93 89 8 TRUE 1.33
non-small cell lung cancer KRAS_12C ERBB4 Any mutation 156 125 Signature overall -1.62 -4.20 0.25 1213.19 1.00 1041 148 117 8 TRUE 0.83
non-small cell lung cancer KRAS_12C MED12 Any mutation 48 25 Signature 2 -0.64 -1.62 0.23 1083.23 1.00 254 46 23 2 TRUE 0.75
non-small cell lung cancer KRAS_12C MED12 Any mutation 101 72 Signature 4 -0.57 -1.34 0.14 1007.66 1.00 546 94 65 7 TRUE 0.87
non-small cell lung cancer KRAS_12C MED12 Any mutation 149 97 Signature overall -0.60 -1.60 0.35 1070.35 1.00 800 140 88 9 TRUE 0.64
non-small cell lung cancer KRAS_12C RBM10 Any mutation 6 11 Signature 13 0.23 -1.31 1.72 1469.54 1.00 83 5 10 1 FALSE 0.12
non-small cell lung cancer KRAS_12C RBM10 Any mutation 7 11 Signature 15 0.28 -1.35 1.78 1477.83 1.00 121 6 10 1 FALSE 0.14
non-small cell lung cancer KRAS_12C RBM10 Any mutation 39 17 Signature 18 0.45 -0.49 1.37 1544.50 1.00 101 33 11 6 FALSE 0.46
non-small cell lung cancer KRAS_12C RBM10 Any mutation 7 21 Signature 1A 0.22 -1.45 1.63 1554.80 1.00 239 6 20 1 FALSE 0.11
non-small cell lung cancer KRAS_12C RBM10 Any mutation 48 32 Signature 2 0.78 0.00 1.54 1527.25 1.00 253 39 23 9 FALSE 1.31
non-small cell lung cancer KRAS_12C RBM10 Any mutation 11 30 Signature 3 -0.63 -2.23 0.77 1590.56 1.00 205 11 30 0 FALSE 0.38
non-small cell lung cancer KRAS_12C RBM10 Any mutation 103 128 Signature 4 0.32 -0.18 0.83 1601.84 1.00 505 80 105 23 FALSE 0.68
non-small cell lung cancer KRAS_12C RBM10 Any mutation 134 20 Signature R2 0.19 -0.64 1.10 1487.20 1.00 58 120 6 14 FALSE 0.17
non-small cell lung cancer KRAS_12C RBM10 Any mutation 7 15 Signature U1 0.04 -1.57 1.40 1486.80 1.00 91 6 14 1 FALSE 0.02
non-small cell lung cancer KRAS_12C RBM10 Any mutation 362 285 Signature overall 0.21 -0.66 1.01 1340.38 1.00 1656 306 229 56 FALSE 0.21
non-small cell lung cancer KRAS_12C NF1 Any mutation 38 13 Signature 18 0.03 -1.16 1.12 1331.59 1.00 104 34 9 4 TRUE 0.02
non-small cell lung cancer KRAS_12C NF1 Any mutation 7 13 Signature 1A -0.77 -2.88 0.98 1572.23 1.00 246 7 13 0 TRUE 0.36
non-small cell lung cancer KRAS_12C NF1 Any mutation 50 39 Signature 2 -0.12 -1.03 0.73 1511.45 1.00 246 44 33 6 TRUE 0.11
non-small cell lung cancer KRAS_12C NF1 Any mutation 6 13 Signature 20 -0.36 -1.99 1.10 1499.76 1.00 60 5 12 1 TRUE 0.19
non-small cell lung cancer KRAS_12C NF1 Any mutation 11 15 Signature 3 -0.27 -2.00 1.34 1676.03 1.00 219 10 14 1 TRUE 0.12
non-small cell lung cancer KRAS_12C NF1 Any mutation 100 113 Signature 4 -0.70 -1.44 -0.07 1253.08 1.00 523 91 104 9 TRUE 1.37
non-small cell lung cancer KRAS_12C NF1 Any mutation 9 11 Signature 7 -0.92 -2.96 0.72 1419.75 1.00 88 9 11 0 TRUE 0.50
non-small cell lung cancer KRAS_12C NF1 Any mutation 135 12 Signature R2 -0.69 -1.65 0.28 1296.42 1.00 58 129 6 6 TRUE 0.74
non-small cell lung cancer KRAS_12C NF1 Any mutation 356 229 Signature overall -0.48 -1.36 0.42 1535.14 1.01 1544 329 202 27 TRUE 0.51
non-small cell lung cancer KRAS_12C FLT1 Any mutation 39 13 Signature 18 0.28 -0.66 1.18 1563.54 1.00 103 35 9 4 FALSE 0.26
non-small cell lung cancer KRAS_12C FLT1 Any mutation 48 12 Signature 2 0.27 -0.70 1.24 1128.47 1.00 267 45 9 3 FALSE 0.23
non-small cell lung cancer KRAS_12C FLT1 Any mutation 102 64 Signature 4 0.16 -0.48 0.79 1559.76 1.00 556 92 54 10 FALSE 0.21
non-small cell lung cancer KRAS_12C FLT1 Any mutation 189 89 Signature overall 0.25 -0.62 1.14 1589.30 1.00 926 172 72 17 FALSE 0.24
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 39 24 Signature 18 0.68 -0.23 1.50 1643.00 1.00 98 30 15 9 FALSE 0.94
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 48 30 Signature 2 0.61 -0.28 1.40 1350.56 1.00 256 41 23 7 FALSE 0.81
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 11 19 Signature 3 1.44 0.20 2.68 1487.20 1.00 220 7 15 4 FALSE 1.60
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 101 109 Signature 4 0.39 -0.13 0.91 1354.72 1.00 527 81 89 20 FALSE 0.81
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 134 12 Signature R2 -0.16 -1.18 0.91 1560.36 1.00 60 127 5 7 FALSE 0.11
non-small cell lung cancer KRAS_12C EPHA5 Any mutation 333 194 Signature overall 0.60 -0.48 1.75 1545.95 1.00 1161 286 147 47 FALSE 0.55
non-small cell lung cancer KRAS_12C AR Any mutation 102 56 Signature 4 0.08 -0.74 0.79 1289.54 1.00 560 93 47 9 TRUE 0.08
non-small cell lung cancer KRAS_12C AR Any mutation 102 56 Signature overall 0.09 -4.51 4.71 1406.41 1.00 560 93 47 9 TRUE 0.02
non-small cell lung cancer KRAS_12C ROS1 Any mutation 48 14 Signature 2 -1.22 -2.79 -0.01 124.68 1.02 264 47 13 1 TRUE 0.99
non-small cell lung cancer KRAS_12C ROS1 Any mutation 100 42 Signature 4 -1.23 -2.69 -0.17 93.29 1.03 564 98 40 2 TRUE 1.14
non-small cell lung cancer KRAS_12C ROS1 Any mutation 148 56 Signature overall -1.21 -2.81 -0.03 106.78 1.03 828 145 53 3 TRUE 0.99
non-small cell lung cancer KRAS_12C PIK3CG Any mutation 6 13 Signature 13 -1.19 -4.25 0.97 1617.28 1.00 80 6 13 0 FALSE 0.44
non-small cell lung cancer KRAS_12C PIK3CG Any mutation 50 18 Signature 2 1.26 0.26 2.23 1517.56 1.00 266 42 10 8 FALSE 2.00
non-small cell lung cancer KRAS_12C PIK3CG Any mutation 100 75 Signature 4 -0.26 -1.06 0.43 1180.82 1.00 543 91 66 9 FALSE 0.32
non-small cell lung cancer KRAS_12C PIK3CG Any mutation 134 12 Signature R2 -0.96 -2.09 0.15 1443.76 1.00 58 129 7 5 FALSE 1.04
non-small cell lung cancer KRAS_12C PIK3CG Any mutation 290 118 Signature overall -0.30 -2.04 1.14 1445.07 1.00 947 268 96 22 FALSE 0.15
non-small cell lung cancer KRAS_12C EGFR Any mutation 6 23 Signature 13 -2.79 -4.15 -1.55 1432.69 1.00 72 5 22 1 TRUE 4.61
non-small cell lung cancer KRAS_12C EGFR Any mutation 7 54 Signature 15 -3.10 -4.42 -1.83 1431.52 1.00 84 7 54 0 TRUE 5.47
non-small cell lung cancer KRAS_12C EGFR Any mutation 38 29 Signature 18 -3.19 -4.49 -2.08 1394.76 1.00 87 38 29 0 TRUE 6.47
non-small cell lung cancer KRAS_12C EGFR Any mutation 8 16 Signature 19 -3.07 -4.36 -1.84 1368.91 1.00 39 8 16 0 TRUE 5.17
non-small cell lung cancer KRAS_12C EGFR Any mutation 7 197 Signature 1A -3.17 -4.48 -2.04 1268.32 1.00 134 7 197 0 TRUE 6.20
non-small cell lung cancer KRAS_12C EGFR Any mutation 48 79 Signature 2 -3.24 -4.52 -2.14 1391.96 1.00 213 48 79 0 TRUE 6.64
non-small cell lung cancer KRAS_12C EGFR Any mutation 6 35 Signature 20 -3.07 -4.44 -1.82 1407.88 1.00 43 6 35 0 TRUE 5.20
non-small cell lung cancer KRAS_12C EGFR Any mutation 11 89 Signature 3 -2.88 -4.18 -1.69 1456.31 1.00 152 10 88 1 TRUE 5.16
non-small cell lung cancer KRAS_12C EGFR Any mutation 100 114 Signature 4 -2.31 -3.30 -1.42 1539.44 1.00 514 95 109 5 TRUE 5.57
non-small cell lung cancer KRAS_12C EGFR Any mutation 6 18 Signature 6 -3.08 -4.49 -1.80 1537.38 1.00 34 6 18 0 TRUE 5.10
non-small cell lung cancer KRAS_12C EGFR Any mutation 9 34 Signature 7 -3.09 -4.48 -1.86 1444.38 1.00 69 9 34 0 TRUE 5.29
non-small cell lung cancer KRAS_12C EGFR Any mutation 7 14 Signature 8 -3.09 -4.57 -1.71 1413.72 1.00 43 7 14 0 TRUE 4.94
non-small cell lung cancer KRAS_12C EGFR Any mutation 7 46 Signature U1 -3.11 -4.41 -1.82 1427.06 1.00 63 7 46 0 TRUE 5.51
non-small cell lung cancer KRAS_12C EGFR Any mutation 274 853 Signature overall -3.02 -3.97 -2.22 1327.35 1.00 1731 267 846 7 TRUE 10.54
non-small cell lung cancer KRAS_12C ARID1B Any mutation 48 13 Signature 2 -0.26 -1.47 1.14 1230.66 1.00 266 45 10 3 TRUE 0.16
non-small cell lung cancer KRAS_12C ARID1B Any mutation 100 42 Signature 4 -0.81 -2.13 0.18 371.01 1.01 564 98 40 2 TRUE 0.76
non-small cell lung cancer KRAS_12C ARID1B Any mutation 148 55 Signature overall -0.54 -1.99 0.80 1056.03 1.01 830 143 50 5 TRUE 0.34
non-small cell lung cancer KRAS_12C MET Any mutation 48 23 Signature 2 -1.65 -4.13 -0.15 1508.67 1.00 256 48 23 0 TRUE 1.01
non-small cell lung cancer KRAS_12C MET Any mutation 11 11 Signature 3 -0.72 -2.56 1.23 1499.60 1.00 223 10 10 1 TRUE 0.35
non-small cell lung cancer KRAS_12C MET Any mutation 100 34 Signature 4 -0.85 -2.20 0.22 1490.58 1.00 575 97 31 3 TRUE 0.78
non-small cell lung cancer KRAS_12C MET Any mutation 159 68 Signature overall -1.05 -2.78 0.44 1552.52 1.00 1054 155 64 4 TRUE 0.70
non-small cell lung cancer KRAS_12C BRAF Any mutation 38 11 Signature 18 -1.46 -3.26 -0.17 1477.73 1.00 101 38 11 0 TRUE 1.13
non-small cell lung cancer KRAS_12C BRAF Any mutation 48 20 Signature 2 -1.18 -2.58 0.05 1470.72 1.00 257 47 19 1 TRUE 1.10
non-small cell lung cancer KRAS_12C BRAF Any mutation 11 20 Signature 3 -0.89 -2.40 0.47 1535.55 1.00 213 10 19 1 TRUE 0.65
non-small cell lung cancer KRAS_12C BRAF Any mutation 100 50 Signature 4 -0.71 -1.71 0.13 1555.09 1.00 559 95 45 5 TRUE 0.87
non-small cell lung cancer KRAS_12C BRAF Any mutation 197 101 Signature overall -1.07 -2.32 0.02 1396.28 1.00 1130 190 94 7 TRUE 1.13
non-small cell lung cancer KRAS_12C CARD11 Any mutation 49 16 Signature 2 0.34 -0.59 1.31 1368.37 1.00 265 45 12 4 FALSE 0.33
non-small cell lung cancer KRAS_12C CARD11 Any mutation 100 63 Signature 4 0.19 -0.48 0.81 1291.44 1.00 553 90 53 10 FALSE 0.25
non-small cell lung cancer KRAS_12C CARD11 Any mutation 149 79 Signature overall 0.26 -0.84 1.37 1505.84 1.00 818 135 65 14 FALSE 0.19
non-small cell lung cancer KRAS_12C INPP4B Any mutation 49 15 Signature 2 0.47 -0.47 1.50 1477.65 1.00 266 45 11 4 FALSE 0.51
non-small cell lung cancer KRAS_12C INPP4B Any mutation 100 60 Signature 4 0.38 -0.24 1.00 1096.76 1.00 561 89 49 11 FALSE 0.63
non-small cell lung cancer KRAS_12C INPP4B Any mutation 149 75 Signature overall 0.41 -0.68 1.52 1398.83 1.00 827 134 60 15 FALSE 0.36
non-small cell lung cancer KRAS_12C NFE2L2 Any mutation 6 15 Signature 13 -1.10 -3.66 0.60 1602.94 1.00 80 6 15 0 FALSE 0.52
non-small cell lung cancer KRAS_12C NFE2L2 Any mutation 48 32 Signature 2 -0.42 -1.54 0.58 1501.61 1.00 255 44 28 4 FALSE 0.36
non-small cell lung cancer KRAS_12C NFE2L2 Any mutation 101 20 Signature 4 -0.67 -1.96 0.51 1564.60 1.00 584 99 18 2 FALSE 0.53
non-small cell lung cancer KRAS_12C NFE2L2 Any mutation 155 67 Signature overall -0.73 -2.35 0.60 1450.46 1.00 919 149 61 6 FALSE 0.48
non-small cell lung cancer KRAS_12C GLI1 Any mutation 98 44 Signature 4 0.34 -0.50 1.10 1250.32 1.00 504 89 35 9 FALSE 0.40
non-small cell lung cancer KRAS_12C GLI1 Any mutation 98 44 Signature overall 0.26 -4.22 4.69 1641.06 1.00 504 89 35 9 FALSE 0.05
non-small cell lung cancer KRAS_12C ZFHX3 Any mutation 45 18 Signature 2 -1.29 -3.29 0.17 1529.56 1.00 228 44 17 1 FALSE 0.82
non-small cell lung cancer KRAS_12C ZFHX3 Any mutation 97 61 Signature 4 -0.49 -1.30 0.30 1387.09 1.00 487 90 54 7 FALSE 0.62
non-small cell lung cancer KRAS_12C ZFHX3 Any mutation 121 14 Signature R2 -1.33 -2.48 -0.31 1197.65 1.00 47 116 9 5 FALSE 1.85
non-small cell lung cancer KRAS_12C ZFHX3 Any mutation 263 93 Signature overall -1.01 -2.67 0.53 1444.16 1.00 762 250 80 13 FALSE 0.67
non-small cell lung cancer KRAS_12C MGA Any mutation 45 28 Signature 2 -0.78 -2.15 0.38 1479.80 1.00 230 43 26 2 FALSE 0.65
non-small cell lung cancer KRAS_12C MGA Any mutation 99 79 Signature 4 0.41 -0.19 0.99 1497.16 1.00 480 82 62 17 FALSE 0.77
non-small cell lung cancer KRAS_12C MGA Any mutation 121 13 Signature R2 -0.27 -1.25 0.80 1483.14 1.00 51 113 5 8 FALSE 0.21
non-small cell lung cancer KRAS_12C MGA Any mutation 265 120 Signature overall -0.20 -1.70 1.37 1454.04 1.00 761 238 93 27 FALSE 0.10
non-small cell lung cancer KRAS_12C PREX2 Any mutation 64 52 Signature 4 0.42 -0.29 1.12 1336.73 1.00 266 52 40 12 FALSE 0.60
non-small cell lung cancer KRAS_12C PREX2 Any mutation 64 52 Signature overall 0.40 -4.26 4.72 1245.25 1.00 266 52 40 12 FALSE 0.08
non-small cell lung cancer KRAS_12C AMER1 Any mutation 48 11 Signature 2 0.43 -0.85 1.71 1513.21 1.00 268 45 8 3 FALSE 0.30
non-small cell lung cancer KRAS_12C AMER1 Any mutation 101 83 Signature 4 0.07 -0.61 0.65 1145.64 1.00 547 89 71 12 FALSE 0.08
non-small cell lung cancer KRAS_12C AMER1 Any mutation 149 94 Signature overall 0.24 -1.51 2.07 1550.65 1.00 815 134 79 15 FALSE 0.11
non-small cell lung cancer KRAS_12C EPHA7 Any mutation 9 13 Signature 3 0.83 -0.94 2.59 1418.94 1.00 197 7 11 2 FALSE 0.45
non-small cell lung cancer KRAS_12C EPHA7 Any mutation 96 51 Signature 4 -0.25 -1.16 0.62 1635.79 1.00 495 90 45 6 FALSE 0.23
non-small cell lung cancer KRAS_12C EPHA7 Any mutation 105 64 Signature overall 0.32 -1.78 2.58 1636.58 1.00 692 97 56 8 FALSE 0.11
colorectal cancer RAS_13 SPEN Any mutation 58 18 Signature 15 -1.82 -4.20 -0.19 1473.72 1.00 314 58 18 0 FALSE 1.11
colorectal cancer RAS_13 SPEN Any mutation 57 38 Signature 1A 0.12 -1.15 1.20 1413.79 1.00 760 53 34 4 FALSE 0.07
colorectal cancer RAS_13 SPEN Any mutation 42 61 Signature 6 -1.16 -2.36 -0.09 1535.75 1.00 227 39 58 3 FALSE 1.32
colorectal cancer RAS_13 SPEN Any mutation 162 138 Signature overall -0.83 -2.41 0.61 1472.24 1.00 1323 153 129 9 FALSE 0.56
colorectal cancer RAS_13 KMT2C Any mutation 7 32 Signature 10 0.02 -1.36 1.32 1311.21 1.00 19 3 28 4 FALSE 0.01
colorectal cancer RAS_13 KMT2C Any mutation 58 22 Signature 15 0.31 -0.76 1.24 1473.70 1.00 309 53 17 5 FALSE 0.26
colorectal cancer RAS_13 KMT2C Any mutation 56 60 Signature 1A 0.31 -0.66 1.14 1280.44 1.00 726 50 54 6 FALSE 0.31
colorectal cancer RAS_13 KMT2C Any mutation 40 65 Signature 6 -0.82 -1.91 0.11 1478.46 1.00 214 36 61 4 FALSE 0.96
colorectal cancer RAS_13 KMT2C Any mutation 161 179 Signature overall -0.04 -1.39 1.36 1531.62 1.00 1268 142 160 19 FALSE 0.02
colorectal cancer RAS_13 TP53 Any mutation 62 311 Signature 15 -0.42 -0.88 0.01 1451.88 1.00 75 22 271 40 TRUE 1.17
colorectal cancer RAS_13 TP53 Any mutation 58 655 Signature 1A -0.80 -1.23 -0.33 1400.76 1.00 206 27 624 31 TRUE 3.45
colorectal cancer RAS_13 TP53 Any mutation 8 56 Signature 2 -0.51 -1.14 0.17 1281.39 1.00 26 3 51 5 TRUE 0.88
colorectal cancer RAS_13 TP53 Any mutation 45 236 Signature 6 -0.25 -0.74 0.28 1483.65 1.00 97 15 206 30 TRUE 0.49
colorectal cancer RAS_13 TP53 Any mutation 195 1607 Signature overall -0.58 -0.98 -0.18 1401.72 1.00 527 73 1485 122 TRUE 2.38
colorectal cancer RAS_13 ATRX Any mutation 6 19 Signature 10 0.33 -1.18 1.72 1415.53 1.00 23 3 16 3 TRUE 0.18
colorectal cancer RAS_13 ATRX Any mutation 60 46 Signature 1A 0.54 -0.39 1.40 1559.84 1.00 751 54 40 6 TRUE 0.63
colorectal cancer RAS_13 ATRX Any mutation 41 29 Signature 6 -0.54 -2.01 0.57 1468.59 1.00 246 39 27 2 TRUE 0.39
colorectal cancer RAS_13 ATRX Any mutation 107 94 Signature overall 0.09 -1.41 1.57 1496.28 1.00 1020 96 83 11 TRUE 0.04
colorectal cancer RAS_13 ATR Any mutation 6 28 Signature 10 -0.03 -1.56 1.35 1516.99 1.00 21 3 25 3 FALSE 0.01
colorectal cancer RAS_13 ATR Any mutation 59 12 Signature 15 1.04 -0.17 2.18 1518.99 1.00 322 54 7 5 FALSE 1.08
colorectal cancer RAS_13 ATR Any mutation 57 32 Signature 1A -0.18 -1.68 1.07 1501.61 1.00 759 55 30 2 FALSE 0.10
colorectal cancer RAS_13 ATR Any mutation 41 28 Signature 6 -0.60 -1.95 0.55 1522.57 1.00 253 39 26 2 FALSE 0.46
colorectal cancer RAS_13 ATR Any mutation 163 100 Signature overall 0.06 -1.38 1.43 1427.45 1.00 1355 151 88 12 FALSE 0.03
colorectal cancer RAS_13 FBXW7 Any mutation 58 48 Signature 15 0.34 -0.39 0.98 1482.68 1.00 295 49 39 9 TRUE 0.48
colorectal cancer RAS_13 FBXW7 Any mutation 61 144 Signature 1A 0.83 0.27 1.37 1465.70 1.00 681 41 124 20 TRUE 2.56
colorectal cancer RAS_13 FBXW7 Any mutation 42 78 Signature 6 0.50 -0.14 1.12 1510.59 1.00 213 28 64 14 TRUE 0.92
colorectal cancer RAS_13 FBXW7 Any mutation 165 287 Signature overall 0.47 -0.40 1.20 1411.38 1.00 1206 121 243 44 TRUE 0.62
colorectal cancer RAS_13 FLT4 Any mutation 58 14 Signature 15 -1.63 -4.16 0.05 1547.29 1.00 314 58 14 0 TRUE 0.91
colorectal cancer RAS_13 FLT4 Any mutation 57 54 Signature 1A -0.25 -1.42 0.74 1346.84 1.00 742 53 50 4 TRUE 0.19
colorectal cancer RAS_13 FLT4 Any mutation 41 51 Signature 6 -0.31 -1.24 0.53 1490.55 1.00 231 35 45 6 TRUE 0.31
colorectal cancer RAS_13 FLT4 Any mutation 160 133 Signature overall -0.90 -2.41 0.33 1290.30 1.00 1310 150 123 10 TRUE 0.72
colorectal cancer RAS_13 PTPRD Any mutation 58 14 Signature 15 -1.36 -3.86 0.23 1522.38 1.00 315 58 14 0 FALSE 0.71
colorectal cancer RAS_13 PTPRD Any mutation 57 31 Signature 1A 0.03 -1.20 1.17 1152.20 1.00 763 54 28 3 FALSE 0.02
colorectal cancer RAS_13 PTPRD Any mutation 41 31 Signature 6 -0.18 -1.32 0.85 1543.88 1.00 248 37 27 4 FALSE 0.13
colorectal cancer RAS_13 PTPRD Any mutation 161 95 Signature overall -0.43 -1.96 0.92 1528.61 1.00 1349 152 86 9 FALSE 0.26
colorectal cancer RAS_13 CREBBP Any mutation 58 27 Signature 15 -0.40 -1.49 0.58 1552.35 1.00 308 55 24 3 TRUE 0.35
colorectal cancer RAS_13 CREBBP Any mutation 57 45 Signature 1A 0.48 -0.48 1.35 1256.11 1.00 754 51 39 6 TRUE 0.52
colorectal cancer RAS_13 CREBBP Any mutation 43 80 Signature 6 -0.64 -1.48 0.13 1504.76 1.00 218 37 74 6 TRUE 0.94
colorectal cancer RAS_13 CREBBP Any mutation 162 167 Signature overall -0.23 -1.32 0.91 1427.39 1.00 1303 146 151 16 TRUE 0.16
colorectal cancer RAS_13 AXIN2 Any mutation 58 17 Signature 15 -1.10 -3.62 0.25 1581.69 1.00 312 58 17 0 TRUE 0.58
colorectal cancer RAS_13 AXIN2 Any mutation 57 36 Signature 1A 0.17 -0.94 1.17 1459.96 1.00 760 53 32 4 TRUE 0.12
colorectal cancer RAS_13 AXIN2 Any mutation 42 40 Signature 6 0.03 -0.92 0.88 1575.89 1.00 245 36 34 6 TRUE 0.03
colorectal cancer RAS_13 AXIN2 Any mutation 157 93 Signature overall -0.28 -1.82 0.98 1325.95 1.00 1317 147 83 10 TRUE 0.16
colorectal cancer RAS_13 PTPRS Any mutation 59 38 Signature 15 -0.36 -1.33 0.46 1446.82 1.00 289 55 34 4 FALSE 0.36
colorectal cancer RAS_13 PTPRS Any mutation 55 95 Signature 1A 0.61 -0.09 1.29 1376.74 1.00 696 43 83 12 FALSE 1.08
colorectal cancer RAS_13 PTPRS Any mutation 41 83 Signature 6 -0.42 -1.23 0.33 1422.42 1.00 211 34 76 7 FALSE 0.53
colorectal cancer RAS_13 PTPRS Any mutation 160 232 Signature overall -0.05 -1.00 0.87 1431.01 1.00 1217 135 207 25 FALSE 0.04
colorectal cancer RAS_13 SMARCA4 Any mutation 58 22 Signature 15 -0.54 -1.73 0.53 1461.43 1.00 313 56 20 2 FALSE 0.47
colorectal cancer RAS_13 SMARCA4 Any mutation 59 74 Signature 1A 0.04 -0.79 0.87 1439.98 1.00 733 52 67 7 FALSE 0.04
colorectal cancer RAS_13 SMARCA4 Any mutation 41 52 Signature 6 -0.71 -1.83 0.19 1396.26 1.00 236 38 49 3 FALSE 0.77
colorectal cancer RAS_13 SMARCA4 Any mutation 158 148 Signature overall -0.39 -1.56 0.65 1209.42 1.00 1282 146 136 12 FALSE 0.33
colorectal cancer RAS_13 PTPRT Any mutation 8 23 Signature 10 0.57 -0.65 1.69 1576.40 1.00 21 3 18 5 FALSE 0.47
colorectal cancer RAS_13 PTPRT Any mutation 58 25 Signature 15 -0.50 -1.74 0.58 1519.82 1.00 305 56 23 2 FALSE 0.40
colorectal cancer RAS_13 PTPRT Any mutation 57 66 Signature 1A 0.69 -0.10 1.38 1472.13 1.00 733 48 57 9 FALSE 1.13
colorectal cancer RAS_13 PTPRT Any mutation 41 43 Signature 6 -0.11 -1.01 0.72 1397.44 1.00 235 36 38 5 FALSE 0.09
colorectal cancer RAS_13 PTPRT Any mutation 164 157 Signature overall 0.16 -0.98 1.22 1326.97 1.00 1294 143 136 21 FALSE 0.11
colorectal cancer RAS_13 PIK3CA Any mutation 58 63 Signature 15 0.31 -0.35 0.93 1467.17 1.00 280 47 52 11 TRUE 0.46
colorectal cancer RAS_13 PIK3CA Any mutation 61 191 Signature 1A 0.68 0.17 1.19 1496.98 1.00 634 39 169 22 TRUE 2.05
colorectal cancer RAS_13 PIK3CA Any mutation 9 43 Signature 2 0.84 -0.07 1.79 1479.25 1.00 40 2 36 7 TRUE 1.08
colorectal cancer RAS_13 PIK3CA Any mutation 47 95 Signature 6 0.86 0.31 1.42 1575.90 1.00 206 25 73 22 TRUE 2.64
colorectal cancer RAS_13 PIK3CA Any mutation 181 434 Signature overall 0.59 -0.10 1.23 1448.35 1.00 1206 116 369 65 TRUE 1.11
colorectal cancer RAS_13 ALK Any mutation 58 16 Signature 15 0.33 -0.85 1.29 1548.60 1.00 314 55 13 3 TRUE 0.26
colorectal cancer RAS_13 ALK Any mutation 59 35 Signature 1A 1.06 0.20 1.89 1591.59 1.00 761 52 28 7 TRUE 1.91
colorectal cancer RAS_13 ALK Any mutation 41 37 Signature 6 0.39 -0.48 1.21 1452.97 1.00 246 35 31 6 TRUE 0.43
colorectal cancer RAS_13 ALK Any mutation 163 101 Signature overall 0.69 -0.35 1.72 1369.34 1.00 1345 144 82 19 TRUE 0.72
colorectal cancer RAS_13 RNF43 Any mutation 58 31 Signature 15 -2.09 -5.08 -0.41 1489.32 1.00 306 58 31 0 TRUE 1.04
colorectal cancer RAS_13 RNF43 Any mutation 60 93 Signature 1A 0.76 0.06 1.43 1557.57 1.00 734 47 80 13 TRUE 1.50
colorectal cancer RAS_13 RNF43 Any mutation 44 102 Signature 6 -0.58 -1.36 0.15 1524.88 1.00 203 35 93 9 TRUE 0.87
colorectal cancer RAS_13 RNF43 Any mutation 162 226 Signature overall -0.63 -2.62 1.00 1518.57 1.00 1243 140 204 22 TRUE 0.31
colorectal cancer RAS_13 PTEN Any mutation 58 22 Signature 15 0.48 -0.40 1.38 1260.43 1.00 311 53 17 5 TRUE 0.54
colorectal cancer RAS_13 PTEN Any mutation 61 64 Signature 1A 1.05 0.33 1.71 1265.51 1.00 748 49 52 12 TRUE 2.69
colorectal cancer RAS_13 PTEN Any mutation 42 57 Signature 6 0.12 -0.70 0.89 1569.73 1.00 239 35 50 7 TRUE 0.12
colorectal cancer RAS_13 PTEN Any mutation 166 156 Signature overall 0.52 -0.44 1.44 1437.29 1.00 1320 140 130 26 TRUE 0.56
colorectal cancer RAS_13 BCOR Any mutation 58 13 Signature 15 -0.59 -2.25 0.75 1520.93 1.00 316 57 12 1 FALSE 0.37
colorectal cancer RAS_13 BCOR Any mutation 57 27 Signature 1A 0.49 -0.63 1.47 1725.10 1.00 765 53 23 4 FALSE 0.43
colorectal cancer RAS_13 BCOR Any mutation 43 49 Signature 6 -0.33 -1.32 0.57 1498.50 1.00 238 38 44 5 FALSE 0.31
colorectal cancer RAS_13 BCOR Any mutation 162 100 Signature overall -0.16 -1.42 1.05 1564.74 1.00 1342 151 89 11 FALSE 0.10
colorectal cancer RAS_13 CTNNB1 Any mutation 58 22 Signature 15 0.28 -0.74 1.11 1582.14 1.00 309 55 19 3 TRUE 0.26
colorectal cancer RAS_13 CTNNB1 Any mutation 57 61 Signature 1A 0.86 0.16 1.55 1486.47 1.00 740 47 51 10 TRUE 1.87
colorectal cancer RAS_13 CTNNB1 Any mutation 41 33 Signature 6 0.68 -0.13 1.40 1472.16 1.00 247 34 26 7 TRUE 1.09
colorectal cancer RAS_13 CTNNB1 Any mutation 156 116 Signature overall 0.59 -0.22 1.42 1540.99 1.00 1296 136 96 20 TRUE 0.79
colorectal cancer RAS_13 ARID1A Any mutation 59 39 Signature 15 -0.36 -1.28 0.43 1250.40 1.00 307 55 35 4 TRUE 0.38
colorectal cancer RAS_13 ARID1A Any mutation 62 130 Signature 1A 0.36 -0.30 0.99 1352.66 1.00 705 48 116 14 TRUE 0.58
colorectal cancer RAS_13 ARID1A Any mutation 42 99 Signature 6 -0.43 -1.20 0.27 1668.92 1.00 209 34 91 8 TRUE 0.60
colorectal cancer RAS_13 ARID1A Any mutation 168 281 Signature overall -0.09 -0.99 0.75 1410.51 1.00 1244 140 253 28 TRUE 0.08
colorectal cancer RAS_13 PIK3R1 Any mutation 58 17 Signature 15 -0.43 -1.76 0.70 1250.77 1.00 315 56 15 2 TRUE 0.30
colorectal cancer RAS_13 PIK3R1 Any mutation 57 31 Signature 1A -0.27 -1.77 0.85 1717.40 1.00 762 55 29 2 TRUE 0.17
colorectal cancer RAS_13 PIK3R1 Any mutation 41 31 Signature 6 -0.15 -1.21 0.84 1515.34 1.00 247 37 27 4 TRUE 0.11
colorectal cancer RAS_13 PIK3R1 Any mutation 160 96 Signature overall -0.32 -1.60 0.98 1528.07 1.00 1345 151 87 9 TRUE 0.21
colorectal cancer RAS_13 FAT1 Any mutation 11 44 Signature 10 0.45 -0.73 1.67 1345.13 1.00 20 3 36 8 FALSE 0.34
colorectal cancer RAS_13 FAT1 Any mutation 58 29 Signature 15 -1.13 -2.74 0.10 1524.15 1.00 308 57 28 1 FALSE 0.89
colorectal cancer RAS_13 FAT1 Any mutation 59 66 Signature 1A 0.98 0.23 1.69 1378.14 1.00 744 48 55 11 FALSE 2.03
colorectal cancer RAS_13 FAT1 Any mutation 44 67 Signature 6 0.00 -0.78 0.72 1400.35 1.00 226 35 58 9 FALSE 0.00
colorectal cancer RAS_13 FAT1 Any mutation 172 206 Signature overall 0.04 -1.37 1.40 1334.71 1.00 1298 143 177 29 FALSE 0.02
colorectal cancer RAS_13 CIC Any mutation 58 19 Signature 15 -0.81 -2.44 0.40 1481.26 1.00 316 57 18 1 TRUE 0.60
colorectal cancer RAS_13 CIC Any mutation 59 58 Signature 1A 0.25 -0.71 1.12 1428.74 1.00 745 52 51 7 TRUE 0.24
colorectal cancer RAS_13 CIC Any mutation 41 43 Signature 6 -0.87 -2.21 0.13 1218.22 1.00 240 39 41 2 TRUE 0.83
colorectal cancer RAS_13 CIC Any mutation 158 120 Signature overall -0.47 -1.77 0.63 1439.09 1.00 1301 148 110 10 TRUE 0.34
colorectal cancer RAS_13 NCOR1 Any mutation 58 22 Signature 15 0.02 -1.06 1.00 1431.53 1.00 312 54 18 4 FALSE 0.01
colorectal cancer RAS_13 NCOR1 Any mutation 58 44 Signature 1A -0.16 -1.33 0.80 1466.52 1.00 753 55 41 3 FALSE 0.12
colorectal cancer RAS_13 NCOR1 Any mutation 42 43 Signature 6 -0.19 -1.07 0.69 1402.13 1.00 241 37 38 5 FALSE 0.17
colorectal cancer RAS_13 NCOR1 Any mutation 162 125 Signature overall -0.18 -1.31 0.85 1529.06 1.00 1327 149 112 13 FALSE 0.13
colorectal cancer RAS_13 POLE Any mutation 58 19 Signature 15 -0.76 -2.44 0.48 1520.39 1.00 313 57 18 1 TRUE 0.51
colorectal cancer RAS_13 POLE Any mutation 59 36 Signature 1A 0.77 -0.23 1.63 1529.70 1.00 761 53 30 6 TRUE 0.98
colorectal cancer RAS_13 POLE Any mutation 42 54 Signature 6 0.00 -0.88 0.78 1271.51 1.00 232 35 47 7 TRUE 0.00
colorectal cancer RAS_13 POLE Any mutation 164 129 Signature overall 0.09 -1.28 1.43 1478.78 1.00 1326 147 112 17 TRUE 0.05
colorectal cancer RAS_13 TGFBR2 Any mutation 58 11 Signature 15 0.08 -1.15 1.16 1516.22 1.00 319 56 9 2 TRUE 0.05
colorectal cancer RAS_13 TGFBR2 Any mutation 57 48 Signature 1A 0.51 -0.43 1.39 1396.02 1.00 750 51 42 6 TRUE 0.57
colorectal cancer RAS_13 TGFBR2 Any mutation 41 43 Signature 6 -0.04 -0.99 0.74 1604.84 1.00 234 36 38 5 TRUE 0.03
colorectal cancer RAS_13 TGFBR2 Any mutation 156 102 Signature overall 0.19 -1.03 1.30 1532.49 1.00 1303 143 89 13 TRUE 0.12
colorectal cancer RAS_13 KMT2A Any mutation 7 22 Signature 10 0.38 -0.93 1.67 1586.14 1.00 24 3 18 4 FALSE 0.25
colorectal cancer RAS_13 KMT2A Any mutation 59 19 Signature 15 -0.42 -1.72 0.72 1437.86 1.00 312 57 17 2 FALSE 0.29
colorectal cancer RAS_13 KMT2A Any mutation 59 53 Signature 1A 0.70 -0.16 1.47 1350.71 1.00 746 51 45 8 FALSE 1.00
colorectal cancer RAS_13 KMT2A Any mutation 41 42 Signature 6 -0.88 -2.21 0.22 1461.44 1.00 240 39 40 2 FALSE 0.81
colorectal cancer RAS_13 KMT2A Any mutation 166 136 Signature overall -0.02 -1.28 1.26 1271.82 1.00 1322 150 120 16 FALSE 0.01
colorectal cancer RAS_13 BRCA2 Any mutation 7 37 Signature 10 -0.03 -1.45 1.40 1432.59 1.00 22 3 33 4 TRUE 0.02
colorectal cancer RAS_13 BRCA2 Any mutation 58 17 Signature 15 -0.79 -2.52 0.54 1656.34 1.00 316 57 16 1 TRUE 0.50
colorectal cancer RAS_13 BRCA2 Any mutation 61 50 Signature 1A 1.11 0.31 1.86 1196.65 1.00 753 51 40 10 TRUE 2.39
colorectal cancer RAS_13 BRCA2 Any mutation 43 62 Signature 6 -0.40 -1.32 0.44 1575.57 1.00 231 37 56 6 TRUE 0.41
colorectal cancer RAS_13 BRCA2 Any mutation 169 166 Signature overall 0.00 -1.41 1.47 1657.49 1.00 1322 148 145 21 TRUE 0.00
colorectal cancer RAS_13 NOTCH3 Any mutation 58 27 Signature 15 0.14 -0.76 0.97 1484.43 1.00 310 53 22 5 TRUE 0.13
colorectal cancer RAS_13 NOTCH3 Any mutation 57 70 Signature 1A 0.15 -0.69 0.91 1430.43 1.00 736 51 64 6 TRUE 0.15
colorectal cancer RAS_13 NOTCH3 Any mutation 42 72 Signature 6 -0.10 -0.84 0.59 1397.38 1.00 225 34 64 8 TRUE 0.11
colorectal cancer RAS_13 NOTCH3 Any mutation 157 169 Signature overall 0.05 -0.88 1.02 1358.29 1.00 1271 138 150 19 TRUE 0.04
colorectal cancer RAS_13 NOTCH4 Any mutation 58 18 Signature 15 -0.78 -2.19 0.36 1344.11 1.00 304 57 17 1 TRUE 0.62
colorectal cancer RAS_13 NOTCH4 Any mutation 55 43 Signature 1A -0.32 -1.46 0.69 1477.25 1.00 731 52 40 3 TRUE 0.25
colorectal cancer RAS_13 NOTCH4 Any mutation 41 41 Signature 6 -0.44 -1.46 0.49 1494.90 1.00 231 37 37 4 TRUE 0.43
colorectal cancer RAS_13 NOTCH4 Any mutation 154 102 Signature overall -0.50 -1.65 0.67 1458.52 1.00 1266 146 94 8 TRUE 0.41
colorectal cancer RAS_13 ERBB3 Any mutation 58 18 Signature 15 0.33 -0.72 1.16 1454.08 1.00 312 55 15 3 TRUE 0.30
colorectal cancer RAS_13 ERBB3 Any mutation 58 46 Signature 1A 0.86 0.13 1.61 1555.42 1.00 757 50 38 8 TRUE 1.55
colorectal cancer RAS_13 ERBB3 Any mutation 42 34 Signature 6 0.49 -0.35 1.29 1256.43 1.00 246 36 28 6 TRUE 0.63
colorectal cancer RAS_13 ERBB3 Any mutation 158 98 Signature overall 0.55 -0.34 1.43 1448.38 1.00 1315 141 81 17 TRUE 0.66
colorectal cancer RAS_13 SMAD4 Any mutation 58 60 Signature 15 -0.65 -1.46 0.08 1458.51 1.00 277 53 55 5 TRUE 1.01
colorectal cancer RAS_13 SMAD4 Any mutation 57 122 Signature 1A -1.00 -1.99 -0.20 1532.99 1.00 678 55 120 2 TRUE 1.56
colorectal cancer RAS_13 SMAD4 Any mutation 8 11 Signature 2 -0.06 -1.16 1.26 1337.88 1.00 66 5 8 3 TRUE 0.04
colorectal cancer RAS_13 SMAD4 Any mutation 41 57 Signature 6 -0.54 -1.33 0.25 1488.10 1.00 226 36 52 5 TRUE 0.73
colorectal cancer RAS_13 SMAD4 Any mutation 173 301 Signature overall -0.54 -1.23 0.19 1512.78 1.00 1361 155 283 18 TRUE 0.84
colorectal cancer RAS_13 ATM Any mutation 9 39 Signature 10 0.30 -0.88 1.57 1445.80 1.00 19 3 33 6 TRUE 0.20
colorectal cancer RAS_13 ATM Any mutation 59 32 Signature 15 0.37 -0.50 1.16 1468.11 1.00 306 52 25 7 TRUE 0.41
colorectal cancer RAS_13 ATM Any mutation 58 77 Signature 1A 0.69 0.02 1.37 1578.03 1.00 730 48 67 10 TRUE 1.24
colorectal cancer RAS_13 ATM Any mutation 41 48 Signature 6 -0.69 -1.80 0.29 1483.48 1.00 234 38 45 3 TRUE 0.71
colorectal cancer RAS_13 ATM Any mutation 167 196 Signature overall 0.19 -0.97 1.45 1384.26 1.00 1289 141 170 26 TRUE 0.12
colorectal cancer RAS_13 KMT2D Any mutation 58 55 Signature 15 -0.90 -1.91 -0.03 1456.66 1.00 298 55 52 3 FALSE 1.19
colorectal cancer RAS_13 KMT2D Any mutation 60 128 Signature 1A 0.35 -0.29 0.97 1577.59 1.00 717 47 115 13 FALSE 0.55
colorectal cancer RAS_13 KMT2D Any mutation 47 142 Signature 6 -0.48 -1.13 0.13 1532.15 1.00 197 34 129 13 FALSE 0.87
colorectal cancer RAS_13 KMT2D Any mutation 170 344 Signature overall -0.32 -1.34 0.62 1498.19 1.00 1232 139 313 31 FALSE 0.30
colorectal cancer RAS_13 TSC2 Any mutation 58 11 Signature 15 -0.48 -2.01 0.72 1450.24 1.00 317 57 10 1 TRUE 0.30
colorectal cancer RAS_13 TSC2 Any mutation 58 36 Signature 1A 0.19 -0.93 1.18 1617.85 1.00 762 54 32 4 TRUE 0.14
colorectal cancer RAS_13 TSC2 Any mutation 41 44 Signature 6 -0.36 -1.46 0.52 1450.07 1.00 239 37 40 4 TRUE 0.32
colorectal cancer RAS_13 TSC2 Any mutation 157 91 Signature overall -0.20 -1.54 0.98 1506.95 1.00 1318 148 82 9 TRUE 0.12
colorectal cancer RAS_13 APC Any mutation 14 94 Signature 10 0.73 -0.09 1.60 1250.89 1.00 3 0 80 14 TRUE 1.07
colorectal cancer RAS_13 APC Any mutation 6 25 Signature 14 0.81 -0.10 1.75 1458.91 1.00 3 0 19 6 TRUE 1.08
colorectal cancer RAS_13 APC Any mutation 91 469 Signature 15 0.85 0.28 1.50 1592.73 1.00 76 7 385 84 TRUE 2.22
colorectal cancer RAS_13 APC Any mutation 82 962 Signature 1A 0.17 -0.30 0.70 1489.98 1.00 206 15 895 67 TRUE 0.30
colorectal cancer RAS_13 APC Any mutation 13 95 Signature 2 0.49 -0.29 1.30 1596.29 1.00 15 2 84 11 TRUE 0.63
colorectal cancer RAS_13 APC Any mutation 62 355 Signature 6 0.41 -0.14 0.98 1544.34 1.00 83 12 305 50 TRUE 0.83
colorectal cancer RAS_13 APC Any mutation 292 2462 Signature overall 0.34 -0.17 0.86 1258.32 1.00 513 38 2208 254 TRUE 0.71
colorectal cancer RAS_13 ERBB2 Any mutation 58 47 Signature 1A 0.91 0.09 1.68 1399.58 1.00 753 50 39 8 TRUE 1.57
colorectal cancer RAS_13 ERBB2 Any mutation 41 29 Signature 6 0.32 -0.79 1.25 1517.44 1.00 249 37 25 4 TRUE 0.27
colorectal cancer RAS_13 ERBB2 Any mutation 99 76 Signature overall 0.61 -0.84 2.08 1517.63 1.00 1002 87 64 12 TRUE 0.36
colorectal cancer RAS_13 ARID2 Any mutation 58 19 Signature 15 -0.48 -1.80 0.65 1582.90 1.00 313 56 17 2 FALSE 0.35
colorectal cancer RAS_13 ARID2 Any mutation 58 42 Signature 1A 0.10 -1.00 1.04 1398.75 1.00 754 54 38 4 FALSE 0.07
colorectal cancer RAS_13 ARID2 Any mutation 41 27 Signature 6 -0.31 -1.51 0.75 1590.04 1.00 248 38 24 3 FALSE 0.23
colorectal cancer RAS_13 ARID2 Any mutation 161 104 Signature overall -0.28 -1.54 0.87 1428.35 1.00 1335 151 94 10 FALSE 0.19
colorectal cancer RAS_13 MTOR Any mutation 58 17 Signature 15 0.15 -0.95 1.10 1418.22 1.00 315 55 14 3 TRUE 0.11
colorectal cancer RAS_13 MTOR Any mutation 58 48 Signature 1A 0.83 0.05 1.59 1476.08 1.00 753 50 40 8 TRUE 1.41
colorectal cancer RAS_13 MTOR Any mutation 44 45 Signature 6 0.08 -0.77 0.86 1323.99 1.00 237 38 39 6 TRUE 0.07
colorectal cancer RAS_13 MTOR Any mutation 164 122 Signature overall 0.27 -0.83 1.28 1567.37 1.00 1329 146 104 18 TRUE 0.22
colorectal cancer RAS_13 NOTCH1 Any mutation 58 17 Signature 15 -1.73 -4.72 0.08 1403.40 1.00 316 58 17 0 TRUE 0.84
colorectal cancer RAS_13 NOTCH1 Any mutation 62 47 Signature 1A 1.25 0.51 1.95 1409.78 1.00 754 51 36 11 TRUE 3.00
colorectal cancer RAS_13 NOTCH1 Any mutation 43 82 Signature 6 -0.42 -1.24 0.34 1470.56 1.00 217 35 74 8 TRUE 0.52
colorectal cancer RAS_13 NOTCH1 Any mutation 167 157 Signature overall -0.54 -2.29 1.03 1395.82 1.00 1311 148 138 19 TRUE 0.28
colorectal cancer RAS_13 SETD2 Any mutation 7 22 Signature 10 0.48 -0.88 1.82 1545.15 1.00 21 3 18 4 FALSE 0.30
colorectal cancer RAS_13 SETD2 Any mutation 59 13 Signature 15 -0.05 -1.53 1.13 1273.06 1.00 317 57 11 2 FALSE 0.03
colorectal cancer RAS_13 SETD2 Any mutation 57 31 Signature 1A 1.02 0.05 1.93 1535.08 1.00 765 51 25 6 FALSE 1.44
colorectal cancer RAS_13 SETD2 Any mutation 42 39 Signature 6 -0.55 -1.76 0.46 1518.02 1.00 239 39 36 3 FALSE 0.49
colorectal cancer RAS_13 SETD2 Any mutation 165 105 Signature overall 0.24 -1.21 1.60 1415.16 1.00 1342 150 90 15 FALSE 0.14
colorectal cancer RAS_13 EPHA3 Any mutation 6 14 Signature 10 0.60 -0.70 1.92 1536.32 1.00 25 3 11 3 FALSE 0.42
colorectal cancer RAS_13 EPHA3 Any mutation 58 13 Signature 15 -0.32 -1.81 0.81 1287.91 1.00 315 57 12 1 FALSE 0.20
colorectal cancer RAS_13 EPHA3 Any mutation 57 42 Signature 1A 0.63 -0.29 1.49 1370.94 1.00 754 51 36 6 FALSE 0.77
colorectal cancer RAS_13 EPHA3 Any mutation 41 26 Signature 6 -0.05 -1.16 0.92 1488.93 1.00 249 38 23 3 FALSE 0.04
colorectal cancer RAS_13 EPHA3 Any mutation 162 95 Signature overall 0.23 -0.98 1.36 1355.32 1.00 1343 149 82 13 FALSE 0.15
colorectal cancer RAS_13 PTCH1 Any mutation 58 14 Signature 15 -0.16 -1.57 0.95 1392.25 1.00 318 56 12 2 TRUE 0.09
colorectal cancer RAS_13 PTCH1 Any mutation 60 55 Signature 1A 0.78 -0.04 1.50 1566.50 1.00 748 51 46 9 TRUE 1.34
colorectal cancer RAS_13 PTCH1 Any mutation 46 53 Signature 6 -0.06 -0.96 0.71 1444.97 1.00 237 39 46 7 TRUE 0.06
colorectal cancer RAS_13 PTCH1 Any mutation 168 133 Signature overall 0.00 -1.26 1.15 1490.61 1.00 1326 150 115 18 TRUE 0.00
colorectal cancer RAS_13 TET1 Any mutation 10 27 Signature 10 0.76 -0.50 2.04 1302.81 1.00 20 3 20 7 FALSE 0.61
colorectal cancer RAS_13 TET1 Any mutation 58 18 Signature 15 -0.93 -2.80 0.55 1271.34 1.00 306 57 17 1 FALSE 0.58
colorectal cancer RAS_13 TET1 Any mutation 55 25 Signature 1A 0.97 -0.17 1.96 1656.26 1.00 748 50 20 5 FALSE 1.12
colorectal cancer RAS_13 TET1 Any mutation 40 28 Signature 6 -1.16 -2.94 0.19 1358.53 1.00 239 39 27 1 FALSE 0.84
colorectal cancer RAS_13 TET1 Any mutation 163 98 Signature overall -0.09 -1.67 1.42 1350.55 1.00 1313 149 84 14 FALSE 0.04
colorectal cancer RAS_13 SMAD3 Any mutation 58 21 Signature 15 -0.13 -1.23 0.77 1506.74 1.00 313 55 18 3 TRUE 0.10
colorectal cancer RAS_13 SMAD3 Any mutation 57 38 Signature 1A 0.03 -0.98 0.95 1504.02 1.00 759 53 34 4 TRUE 0.02
colorectal cancer RAS_13 SMAD3 Any mutation 41 20 Signature 6 -0.36 -1.54 0.68 1560.50 1.00 252 40 19 1 TRUE 0.28
colorectal cancer RAS_13 SMAD3 Any mutation 156 79 Signature overall -0.15 -1.22 0.80 1502.07 1.00 1324 148 71 8 TRUE 0.11
colorectal cancer RAS_13 GRIN2A Any mutation 58 12 Signature 15 -1.38 -3.80 0.26 1468.73 1.00 318 58 12 0 FALSE 0.72
colorectal cancer RAS_13 GRIN2A Any mutation 57 43 Signature 1A -0.53 -1.95 0.59 1411.45 1.00 748 55 41 2 FALSE 0.37
colorectal cancer RAS_13 GRIN2A Any mutation 41 43 Signature 6 -0.24 -1.26 0.65 1391.56 1.00 235 36 38 5 FALSE 0.21
colorectal cancer RAS_13 GRIN2A Any mutation 161 116 Signature overall -0.45 -1.92 0.88 1479.15 1.00 1323 151 106 10 FALSE 0.27
colorectal cancer RAS_13 ASXL1 Any mutation 58 14 Signature 15 0.22 -0.94 1.32 1603.95 1.00 318 55 11 3 TRUE 0.15
colorectal cancer RAS_13 ASXL1 Any mutation 57 31 Signature 1A 0.22 -0.93 1.21 1617.97 1.00 762 54 28 3 TRUE 0.17
colorectal cancer RAS_13 ASXL1 Any mutation 42 34 Signature 6 0.13 -0.88 0.97 1463.30 1.00 245 37 29 5 TRUE 0.10
colorectal cancer RAS_13 ASXL1 Any mutation 161 90 Signature overall 0.16 -1.00 1.18 1575.62 1.00 1347 149 78 12 TRUE 0.11
colorectal cancer RAS_13 EP300 Any mutation 59 18 Signature 15 -0.37 -1.67 0.75 1242.73 1.00 314 57 16 2 TRUE 0.26
colorectal cancer RAS_13 EP300 Any mutation 57 36 Signature 1A -0.07 -1.24 1.00 1483.40 1.00 757 54 33 3 TRUE 0.05
colorectal cancer RAS_13 EP300 Any mutation 43 51 Signature 6 -0.35 -1.28 0.52 1554.45 1.00 237 38 46 5 TRUE 0.35
colorectal cancer RAS_13 EP300 Any mutation 159 105 Signature overall -0.27 -1.47 0.98 1573.36 1.00 1308 149 95 10 TRUE 0.18
colorectal cancer RAS_13 ERBB4 Any mutation 8 18 Signature 10 0.95 -0.22 2.13 1463.35 1.00 22 3 13 5 TRUE 0.98
colorectal cancer RAS_13 ERBB4 Any mutation 58 23 Signature 15 0.01 -1.12 0.93 1468.65 1.00 310 55 20 3 TRUE 0.01
colorectal cancer RAS_13 ERBB4 Any mutation 57 43 Signature 1A 0.51 -0.39 1.31 1550.15 1.00 753 52 38 5 TRUE 0.59
colorectal cancer RAS_13 ERBB4 Any mutation 43 31 Signature 6 0.62 -0.26 1.44 1551.44 1.00 248 36 24 7 TRUE 0.85
colorectal cancer RAS_13 ERBB4 Any mutation 166 115 Signature overall 0.53 -0.56 1.53 1450.34 1.00 1333 146 95 20 TRUE 0.50
colorectal cancer RAS_13 MED12 Any mutation 58 11 Signature 15 -0.90 -3.34 0.61 1439.37 1.00 317 58 11 0 TRUE 0.40
colorectal cancer RAS_13 MED12 Any mutation 57 34 Signature 1A 0.59 -0.43 1.55 1265.83 1.00 762 52 29 5 TRUE 0.61
colorectal cancer RAS_13 MED12 Any mutation 44 42 Signature 6 0.21 -0.74 0.98 1400.64 1.00 243 37 35 7 TRUE 0.20
colorectal cancer RAS_13 MED12 Any mutation 159 87 Signature overall -0.06 -1.78 1.21 1482.76 1.00 1322 147 75 12 TRUE 0.03
colorectal cancer RAS_13 NF1 Any mutation 7 24 Signature 10 0.17 -1.15 1.42 1297.99 1.00 21 3 20 4 TRUE 0.10
colorectal cancer RAS_13 NF1 Any mutation 58 21 Signature 15 -1.00 -2.67 0.27 1503.33 1.00 311 57 20 1 TRUE 0.75
colorectal cancer RAS_13 NF1 Any mutation 57 40 Signature 1A 0.18 -0.91 1.20 1556.97 1.00 757 53 36 4 TRUE 0.14
colorectal cancer RAS_13 NF1 Any mutation 41 44 Signature 6 -0.71 -1.88 0.31 1470.32 1.00 240 38 41 3 TRUE 0.71
colorectal cancer RAS_13 NF1 Any mutation 163 129 Signature overall -0.33 -1.65 0.88 1282.73 1.00 1329 151 117 12 TRUE 0.22
colorectal cancer RAS_13 EPHA5 Any mutation 7 26 Signature 10 -0.14 -1.61 1.21 1365.66 1.00 20 3 22 4 FALSE 0.08
colorectal cancer RAS_13 EPHA5 Any mutation 58 18 Signature 15 -1.97 -4.64 -0.23 1575.51 1.00 313 58 18 0 FALSE 1.10
colorectal cancer RAS_13 EPHA5 Any mutation 57 49 Signature 1A -1.31 -3.12 0.06 1483.76 1.00 742 56 48 1 FALSE 0.94
colorectal cancer RAS_13 EPHA5 Any mutation 41 36 Signature 6 -0.77 -2.16 0.35 1165.87 1.00 242 38 33 3 FALSE 0.66
colorectal cancer RAS_13 EPHA5 Any mutation 163 129 Signature overall -1.01 -2.71 0.47 1450.14 1.00 1317 155 121 8 FALSE 0.71
colorectal cancer RAS_13 AR Any mutation 59 21 Signature 15 0.01 -1.02 0.91 1321.03 1.00 312 56 18 3 TRUE 0.01
colorectal cancer RAS_13 AR Any mutation 57 33 Signature 1A 0.15 -0.87 1.10 1547.34 1.00 758 54 30 3 TRUE 0.11
colorectal cancer RAS_13 AR Any mutation 43 37 Signature 6 0.21 -0.70 1.03 1482.38 1.00 242 37 31 6 TRUE 0.20
colorectal cancer RAS_13 AR Any mutation 159 91 Signature overall 0.12 -0.88 1.06 1403.67 1.00 1312 147 79 12 TRUE 0.09
colorectal cancer RAS_13 ROS1 Any mutation 10 30 Signature 10 0.74 -0.52 2.08 1390.71 1.00 20 3 23 7 TRUE 0.60
colorectal cancer RAS_13 ROS1 Any mutation 57 28 Signature 1A 0.35 -0.91 1.41 1464.86 1.00 765 54 25 3 TRUE 0.25
colorectal cancer RAS_13 ROS1 Any mutation 41 26 Signature 6 -0.16 -1.32 0.98 1582.19 1.00 247 38 23 3 TRUE 0.10
colorectal cancer RAS_13 ROS1 Any mutation 108 84 Signature overall 0.32 -1.44 1.98 1453.21 1.00 1032 95 71 13 TRUE 0.14
colorectal cancer RAS_13 PIK3CG Any mutation 58 17 Signature 15 -1.79 -4.16 -0.05 1478.60 1.00 312 58 17 0 FALSE 1.00
colorectal cancer RAS_13 PIK3CG Any mutation 57 29 Signature 1A -0.43 -1.99 0.81 1500.08 1.00 761 55 27 2 FALSE 0.26
colorectal cancer RAS_13 PIK3CG Any mutation 42 29 Signature 6 -0.51 -1.80 0.60 1616.19 1.00 246 39 26 3 FALSE 0.39
colorectal cancer RAS_13 PIK3CG Any mutation 162 97 Signature overall -0.82 -2.50 0.71 1355.44 1.00 1338 155 90 7 FALSE 0.51
colorectal cancer RAS_13 ARID1B Any mutation 58 22 Signature 15 -0.47 -1.59 0.48 1408.13 1.00 311 56 20 2 TRUE 0.42
colorectal cancer RAS_13 ARID1B Any mutation 57 53 Signature 1A 0.04 -0.90 0.90 1487.54 1.00 749 52 48 5 TRUE 0.03
colorectal cancer RAS_13 ARID1B Any mutation 41 46 Signature 6 -0.38 -1.34 0.45 1472.37 1.00 236 37 42 4 TRUE 0.39
colorectal cancer RAS_13 ARID1B Any mutation 156 121 Signature overall -0.26 -1.35 0.77 1470.84 1.00 1296 145 110 11 TRUE 0.20
colorectal cancer RAS_13 BRAF Any mutation 58 48 Signature 15 -1.13 -2.16 -0.25 1583.06 1.00 284 55 45 3 TRUE 1.72
colorectal cancer RAS_13 BRAF Any mutation 57 99 Signature 1A -0.97 -1.89 -0.08 1427.16 1.00 696 53 95 4 TRUE 1.46
colorectal cancer RAS_13 BRAF Any mutation 42 60 Signature 6 -1.34 -2.53 -0.44 1514.26 1.00 217 40 58 2 TRUE 2.01
colorectal cancer RAS_13 BRAF Any mutation 157 207 Signature overall -1.14 -2.10 -0.26 1591.10 1.00 1197 148 198 9 TRUE 1.80
colorectal cancer RAS_13 B2M Any mutation 58 20 Signature 15 -0.65 -2.28 0.45 1540.10 1.00 307 57 19 1 FALSE 0.46
colorectal cancer RAS_13 B2M Any mutation 57 46 Signature 1A 0.52 -0.40 1.39 1300.76 1.00 742 51 40 6 FALSE 0.61
colorectal cancer RAS_13 B2M Any mutation 43 51 Signature 6 0.20 -0.60 0.92 1415.84 1.00 235 35 43 8 FALSE 0.22
colorectal cancer RAS_13 B2M Any mutation 163 131 Signature overall 0.07 -1.11 1.14 1558.63 1.00 1308 146 114 17 FALSE 0.04
colorectal cancer RAS_13 CARD11 Any mutation 58 14 Signature 15 -0.06 -1.29 1.06 1284.99 1.00 315 56 12 2 FALSE 0.04
colorectal cancer RAS_13 CARD11 Any mutation 58 58 Signature 1A 0.15 -0.74 0.97 1486.49 1.00 739 53 53 5 FALSE 0.14
colorectal cancer RAS_13 CARD11 Any mutation 43 38 Signature 6 0.17 -0.65 0.95 1432.48 1.00 244 37 32 6 FALSE 0.17
colorectal cancer RAS_13 CARD11 Any mutation 159 110 Signature overall 0.10 -0.94 1.11 1605.27 1.00 1298 146 97 13 FALSE 0.07
colorectal cancer RAS_13 SOX9 Any mutation 58 40 Signature 15 1.00 0.31 1.68 1464.11 1.00 303 44 26 14 FALSE 2.39
colorectal cancer RAS_13 SOX9 Any mutation 58 105 Signature 1A 0.04 -0.75 0.69 1562.19 1.00 697 52 99 6 FALSE 0.04
colorectal cancer RAS_13 SOX9 Any mutation 43 59 Signature 6 0.54 -0.14 1.16 1442.39 1.00 227 32 48 11 FALSE 0.96
colorectal cancer RAS_13 SOX9 Any mutation 159 204 Signature overall 0.52 -0.32 1.32 1454.88 1.00 1227 128 173 31 FALSE 0.68
colorectal cancer RAS_13 SMAD2 Any mutation 58 16 Signature 15 -0.01 -1.16 0.95 1521.82 1.00 313 56 14 2 TRUE 0.01
colorectal cancer RAS_13 SMAD2 Any mutation 58 33 Signature 1A 0.25 -0.74 1.19 1560.51 1.00 763 54 29 4 TRUE 0.21
colorectal cancer RAS_13 SMAD2 Any mutation 41 17 Signature 6 0.04 -1.04 1.00 1459.54 1.00 257 39 15 2 TRUE 0.03
colorectal cancer RAS_13 SMAD2 Any mutation 157 66 Signature overall 0.09 -0.92 1.05 1480.51 1.00 1333 149 58 8 TRUE 0.07
colorectal cancer RAS_13 ZFHX3 Any mutation 7 17 Signature 10 0.32 -0.92 1.54 1573.17 1.00 18 3 13 4 FALSE 0.21
colorectal cancer RAS_13 ZFHX3 Any mutation 52 31 Signature 15 -0.68 -1.85 0.33 1632.66 1.00 278 50 29 2 FALSE 0.64
colorectal cancer RAS_13 ZFHX3 Any mutation 56 80 Signature 1A 0.25 -0.55 0.98 1288.08 1.00 681 48 72 8 FALSE 0.28
colorectal cancer RAS_13 ZFHX3 Any mutation 37 81 Signature 6 -0.54 -1.40 0.22 1394.45 1.00 204 31 75 6 FALSE 0.70
colorectal cancer RAS_13 ZFHX3 Any mutation 152 209 Signature overall -0.17 -1.21 0.89 1519.65 1.00 1181 132 189 20 FALSE 0.12
colorectal cancer RAS_13 MGA Any mutation 8 15 Signature 10 0.92 -0.32 2.19 1575.14 1.00 20 3 10 5 FALSE 0.86
colorectal cancer RAS_13 MGA Any mutation 51 16 Signature 15 -0.09 -1.34 0.93 1010.31 1.00 283 49 14 2 FALSE 0.05
colorectal cancer RAS_13 MGA Any mutation 54 42 Signature 1A 0.24 -0.84 1.17 1466.72 1.00 701 50 38 4 FALSE 0.20
colorectal cancer RAS_13 MGA Any mutation 36 36 Signature 6 -0.03 -1.02 0.90 1515.06 1.00 225 32 32 4 FALSE 0.02
colorectal cancer RAS_13 MGA Any mutation 149 109 Signature overall 0.25 -0.88 1.35 1511.11 1.00 1229 134 94 15 FALSE 0.18
colorectal cancer RAS_13 KMT2B Any mutation 31 18 Signature 15 0.26 -0.82 1.30 1685.82 1.00 154 27 14 4 FALSE 0.20
colorectal cancer RAS_13 KMT2B Any mutation 34 64 Signature 1A 0.24 -0.66 1.07 1704.21 1.00 380 28 58 6 FALSE 0.23
colorectal cancer RAS_13 KMT2B Any mutation 22 86 Signature 6 0.02 -0.82 0.84 1536.68 1.00 108 13 77 9 FALSE 0.02
colorectal cancer RAS_13 KMT2B Any mutation 87 168 Signature overall 0.14 -1.02 1.44 1592.46 1.00 642 68 149 19 FALSE 0.09
colorectal cancer RAS_13 TCF7L2 Any mutation 52 48 Signature 15 0.00 -0.67 0.65 1419.44 1.00 259 45 41 7 FALSE 0.00
colorectal cancer RAS_13 TCF7L2 Any mutation 56 115 Signature 1A 0.08 -0.52 0.63 1479.87 1.00 641 46 105 10 FALSE 0.10
colorectal cancer RAS_13 TCF7L2 Any mutation 6 12 Signature 2 -0.04 -0.98 0.84 1436.63 1.00 55 5 11 1 FALSE 0.03
colorectal cancer RAS_13 TCF7L2 Any mutation 37 69 Signature 6 -0.09 -0.79 0.53 1564.98 1.00 198 30 62 7 FALSE 0.11
colorectal cancer RAS_13 TCF7L2 Any mutation 151 244 Signature overall -0.01 -0.62 0.63 1590.57 1.00 1153 126 219 25 FALSE 0.01
colorectal cancer RAS_13 ANKRD11 Any mutation 51 17 Signature 15 -0.08 -1.21 0.98 1642.30 1.00 278 48 14 3 FALSE 0.05
colorectal cancer RAS_13 ANKRD11 Any mutation 52 47 Signature 1A -0.18 -1.27 0.76 1552.37 1.00 678 49 44 3 FALSE 0.14
colorectal cancer RAS_13 ANKRD11 Any mutation 36 57 Signature 6 -0.21 -1.08 0.59 1377.07 1.00 210 30 51 6 FALSE 0.20
colorectal cancer RAS_13 ANKRD11 Any mutation 143 133 Signature overall -0.17 -1.31 0.85 1511.19 1.00 1186 130 120 13 FALSE 0.12
colorectal cancer RAS_13 POLD1 Any mutation 51 15 Signature 15 -0.20 -1.46 0.90 1405.34 1.00 289 49 13 2 TRUE 0.13
colorectal cancer RAS_13 POLD1 Any mutation 54 43 Signature 1A 0.06 -0.94 1.02 1513.91 1.00 704 50 39 4 TRUE 0.04
colorectal cancer RAS_13 POLD1 Any mutation 36 44 Signature 6 -0.27 -1.25 0.65 1402.48 1.00 224 32 40 4 TRUE 0.24
colorectal cancer RAS_13 POLD1 Any mutation 141 102 Signature overall -0.13 -1.31 0.93 1381.26 1.00 1217 131 92 10 TRUE 0.09
colorectal cancer RAS_13 AMER1 Any mutation 58 34 Signature 15 0.54 -0.30 1.21 1462.36 1.00 300 52 28 6 FALSE 0.79
colorectal cancer RAS_13 AMER1 Any mutation 61 61 Signature 1A 0.94 0.32 1.59 1367.03 1.00 740 50 50 11 FALSE 2.46
colorectal cancer RAS_13 AMER1 Any mutation 42 36 Signature 6 0.86 0.22 1.49 1441.13 1.00 247 33 27 9 FALSE 1.97
colorectal cancer RAS_13 AMER1 Any mutation 161 131 Signature overall 0.79 0.07 1.48 1618.55 1.00 1287 135 105 26 FALSE 1.52
colorectal cancer KRAS_13 SPEN Any mutation 57 18 Signature 15 -1.83 -4.23 -0.18 1430.38 1.00 315 57 18 0 FALSE 1.06
colorectal cancer KRAS_13 SPEN Any mutation 52 38 Signature 1A 0.19 -1.01 1.23 1466.14 1.00 765 48 34 4 FALSE 0.13
colorectal cancer KRAS_13 SPEN Any mutation 39 61 Signature 6 -1.11 -2.36 -0.04 1460.09 1.00 230 36 58 3 FALSE 1.26
colorectal cancer KRAS_13 SPEN Any mutation 153 138 Signature overall -0.78 -2.31 0.66 1313.14 1.00 1332 144 129 9 FALSE 0.53
colorectal cancer KRAS_13 KMT2C Any mutation 7 32 Signature 10 0.02 -1.42 1.38 1429.23 1.00 19 3 28 4 FALSE 0.01
colorectal cancer KRAS_13 KMT2C Any mutation 57 22 Signature 15 0.33 -0.72 1.32 1576.41 1.00 310 52 17 5 FALSE 0.29
colorectal cancer KRAS_13 KMT2C Any mutation 51 60 Signature 1A 0.40 -0.49 1.24 1624.45 1.00 731 45 54 6 FALSE 0.43
colorectal cancer KRAS_13 KMT2C Any mutation 37 65 Signature 6 -0.96 -2.14 0.03 1382.84 1.00 216 34 62 3 FALSE 1.13
colorectal cancer KRAS_13 KMT2C Any mutation 152 179 Signature overall -0.07 -1.35 1.17 1471.06 1.00 1276 134 161 18 FALSE 0.04
colorectal cancer KRAS_13 TP53 Any mutation 61 311 Signature 15 -0.44 -0.88 0.01 1486.07 1.00 75 22 272 39 TRUE 1.28
colorectal cancer KRAS_13 TP53 Any mutation 53 655 Signature 1A -0.82 -1.29 -0.38 1331.54 1.00 208 25 627 28 TRUE 3.49
colorectal cancer KRAS_13 TP53 Any mutation 8 56 Signature 2 -0.52 -1.18 0.13 1363.82 1.00 26 3 51 5 TRUE 0.95
colorectal cancer KRAS_13 TP53 Any mutation 42 236 Signature 6 -0.32 -0.82 0.20 1237.12 1.00 97 15 209 27 TRUE 0.66
colorectal cancer KRAS_13 TP53 Any mutation 186 1607 Signature overall -0.61 -1.00 -0.19 1148.25 1.00 529 71 1492 115 TRUE 2.45
colorectal cancer KRAS_13 ATRX Any mutation 6 19 Signature 10 0.37 -1.10 1.81 1488.92 1.00 23 3 16 3 TRUE 0.21
colorectal cancer KRAS_13 ATRX Any mutation 55 46 Signature 1A 0.63 -0.33 1.46 1484.98 1.00 756 49 40 6 TRUE 0.75
colorectal cancer KRAS_13 ATRX Any mutation 38 29 Signature 6 -0.46 -1.94 0.71 1489.16 1.00 249 36 27 2 TRUE 0.31
colorectal cancer KRAS_13 ATRX Any mutation 99 94 Signature overall 0.16 -1.38 1.78 1388.78 1.00 1028 88 83 11 TRUE 0.08
colorectal cancer KRAS_13 ATR Any mutation 6 28 Signature 10 0.03 -1.47 1.43 1306.54 1.00 21 3 25 3 FALSE 0.02
colorectal cancer KRAS_13 ATR Any mutation 58 12 Signature 15 1.07 -0.09 2.22 1506.06 1.00 323 53 7 5 FALSE 1.17
colorectal cancer KRAS_13 ATR Any mutation 52 32 Signature 1A -0.10 -1.71 1.14 1405.06 1.00 764 50 30 2 FALSE 0.05
colorectal cancer KRAS_13 ATR Any mutation 38 28 Signature 6 -0.50 -2.01 0.68 1554.28 1.00 256 36 26 2 FALSE 0.34
colorectal cancer KRAS_13 ATR Any mutation 154 100 Signature overall 0.08 -1.35 1.50 1485.13 1.00 1364 142 88 12 FALSE 0.04
colorectal cancer KRAS_13 FBXW7 Any mutation 57 48 Signature 15 0.38 -0.35 1.04 1432.02 1.00 296 48 39 9 TRUE 0.54
colorectal cancer KRAS_13 FBXW7 Any mutation 56 144 Signature 1A 0.95 0.41 1.51 1524.86 1.00 686 36 124 20 TRUE 3.09
colorectal cancer KRAS_13 FBXW7 Any mutation 38 78 Signature 6 0.43 -0.26 1.07 1484.16 1.00 215 26 66 12 TRUE 0.67
colorectal cancer KRAS_13 FBXW7 Any mutation 155 287 Signature overall 0.46 -0.37 1.25 1609.39 1.00 1214 113 245 42 TRUE 0.55
colorectal cancer KRAS_13 FLT4 Any mutation 57 14 Signature 15 -1.67 -4.34 0.05 1297.06 1.00 315 57 14 0 TRUE 0.86
colorectal cancer KRAS_13 FLT4 Any mutation 52 54 Signature 1A -0.53 -1.84 0.64 1355.14 1.00 746 49 51 3 TRUE 0.40
colorectal cancer KRAS_13 FLT4 Any mutation 38 51 Signature 6 -0.48 -1.50 0.43 1536.97 1.00 233 33 46 5 TRUE 0.47
colorectal cancer KRAS_13 FLT4 Any mutation 151 133 Signature overall -1.02 -2.69 0.32 1251.78 1.00 1317 143 125 8 TRUE 0.76
colorectal cancer KRAS_13 PTPRD Any mutation 57 14 Signature 15 -1.45 -3.80 0.18 1472.31 1.00 316 57 14 0 FALSE 0.79
colorectal cancer KRAS_13 PTPRD Any mutation 52 31 Signature 1A 0.09 -1.28 1.27 1615.99 1.00 768 49 28 3 FALSE 0.05
colorectal cancer KRAS_13 PTPRD Any mutation 38 31 Signature 6 -0.42 -1.65 0.67 1457.84 1.00 250 35 28 3 FALSE 0.32
colorectal cancer KRAS_13 PTPRD Any mutation 152 95 Signature overall -0.48 -2.01 0.93 1374.40 1.00 1357 144 87 8 FALSE 0.29
colorectal cancer KRAS_13 CREBBP Any mutation 57 27 Signature 15 -0.34 -1.47 0.62 1593.47 1.00 309 54 24 3 TRUE 0.28
colorectal cancer KRAS_13 CREBBP Any mutation 52 45 Signature 1A 0.57 -0.46 1.44 1597.01 1.00 759 46 39 6 TRUE 0.63
colorectal cancer KRAS_13 CREBBP Any mutation 40 80 Signature 6 -0.53 -1.44 0.25 1656.17 1.00 221 34 74 6 TRUE 0.65
colorectal cancer KRAS_13 CREBBP Any mutation 153 167 Signature overall -0.16 -1.43 0.99 1325.80 1.00 1312 137 151 16 TRUE 0.10
colorectal cancer KRAS_13 AXIN2 Any mutation 57 17 Signature 15 -1.18 -3.84 0.26 1572.90 1.00 313 57 17 0 TRUE 0.59
colorectal cancer KRAS_13 AXIN2 Any mutation 52 36 Signature 1A 0.26 -0.84 1.24 1544.43 1.00 765 48 32 4 TRUE 0.20
colorectal cancer KRAS_13 AXIN2 Any mutation 39 40 Signature 6 -0.07 -1.03 0.84 1448.12 1.00 247 34 35 5 TRUE 0.05
colorectal cancer KRAS_13 AXIN2 Any mutation 148 93 Signature overall -0.32 -2.04 0.95 1479.39 1.00 1325 139 84 9 TRUE 0.18
colorectal cancer KRAS_13 PTPRS Any mutation 58 38 Signature 15 -0.36 -1.29 0.53 1370.61 1.00 290 54 34 4 FALSE 0.36
colorectal cancer KRAS_13 PTPRS Any mutation 50 95 Signature 1A 0.72 0.04 1.38 1545.68 1.00 701 38 83 12 FALSE 1.41
colorectal cancer KRAS_13 PTPRS Any mutation 38 83 Signature 6 -0.47 -1.36 0.28 1314.05 1.00 213 32 77 6 FALSE 0.59
colorectal cancer KRAS_13 PTPRS Any mutation 151 232 Signature overall -0.02 -1.01 1.01 1591.64 1.00 1225 127 208 24 FALSE 0.02
colorectal cancer KRAS_13 SMARCA4 Any mutation 57 22 Signature 15 -0.57 -1.75 0.54 1380.60 1.00 314 55 20 2 FALSE 0.48
colorectal cancer KRAS_13 SMARCA4 Any mutation 54 74 Signature 1A 0.13 -0.74 0.93 1345.76 1.00 738 47 67 7 FALSE 0.12
colorectal cancer KRAS_13 SMARCA4 Any mutation 38 52 Signature 6 -0.90 -2.13 0.06 1501.28 1.00 238 36 50 2 FALSE 0.95
colorectal cancer KRAS_13 SMARCA4 Any mutation 149 148 Signature overall -0.44 -1.64 0.66 1420.97 1.00 1290 138 137 11 FALSE 0.34
colorectal cancer KRAS_13 PTPRT Any mutation 8 23 Signature 10 0.65 -0.57 1.90 1516.03 1.00 21 3 18 5 FALSE 0.53
colorectal cancer KRAS_13 PTPRT Any mutation 57 25 Signature 15 -0.43 -1.73 0.63 1362.41 1.00 306 55 23 2 FALSE 0.33
colorectal cancer KRAS_13 PTPRT Any mutation 52 66 Signature 1A 0.79 -0.01 1.51 1485.57 1.00 738 43 57 9 FALSE 1.37
colorectal cancer KRAS_13 PTPRT Any mutation 38 43 Signature 6 -0.02 -0.92 0.80 1370.35 1.00 238 33 38 5 FALSE 0.01
colorectal cancer KRAS_13 PTPRT Any mutation 155 157 Signature overall 0.23 -0.95 1.33 1428.42 1.00 1303 134 136 21 FALSE 0.17
colorectal cancer KRAS_13 PIK3CA Any mutation 57 63 Signature 15 0.35 -0.31 0.96 1551.02 1.00 281 46 52 11 TRUE 0.56
colorectal cancer KRAS_13 PIK3CA Any mutation 56 191 Signature 1A 0.81 0.29 1.32 1439.71 1.00 639 34 169 22 TRUE 2.74
colorectal cancer KRAS_13 PIK3CA Any mutation 9 43 Signature 2 0.87 -0.04 1.82 1439.11 1.00 40 2 36 7 TRUE 1.19
colorectal cancer KRAS_13 PIK3CA Any mutation 43 95 Signature 6 0.84 0.23 1.40 1398.72 1.00 208 23 75 20 TRUE 2.31
colorectal cancer KRAS_13 PIK3CA Any mutation 171 434 Signature overall 0.62 -0.04 1.28 1563.38 1.00 1214 108 371 63 TRUE 1.18
colorectal cancer KRAS_13 ALK Any mutation 57 16 Signature 15 0.38 -0.77 1.42 1690.37 1.00 315 54 13 3 TRUE 0.32
colorectal cancer KRAS_13 ALK Any mutation 54 35 Signature 1A 1.15 0.35 1.95 1564.96 1.00 766 47 28 7 TRUE 2.21
colorectal cancer KRAS_13 ALK Any mutation 38 37 Signature 6 0.49 -0.38 1.31 1430.00 1.00 249 32 31 6 TRUE 0.59
colorectal cancer KRAS_13 ALK Any mutation 154 101 Signature overall 0.76 -0.37 1.78 1490.21 1.00 1354 135 82 19 TRUE 0.82
colorectal cancer KRAS_13 RNF43 Any mutation 57 31 Signature 15 -2.19 -5.41 -0.37 1501.28 1.00 307 57 31 0 TRUE 0.98
colorectal cancer KRAS_13 RNF43 Any mutation 55 93 Signature 1A 0.88 0.19 1.53 1512.95 1.00 739 42 80 13 TRUE 1.91
colorectal cancer KRAS_13 RNF43 Any mutation 41 102 Signature 6 -0.65 -1.48 0.13 1379.36 1.00 205 33 94 8 TRUE 0.96
colorectal cancer KRAS_13 RNF43 Any mutation 153 226 Signature overall -0.62 -2.71 0.95 1336.27 1.00 1251 132 205 21 TRUE 0.31
colorectal cancer KRAS_13 PTEN Any mutation 57 22 Signature 15 0.44 -0.47 1.31 1424.97 1.00 312 52 17 5 TRUE 0.46
colorectal cancer KRAS_13 PTEN Any mutation 56 64 Signature 1A 1.15 0.41 1.80 1681.44 1.00 753 44 52 12 TRUE 2.89
colorectal cancer KRAS_13 PTEN Any mutation 38 57 Signature 6 -0.35 -1.34 0.53 1541.56 1.00 240 34 53 4 TRUE 0.33
colorectal cancer KRAS_13 PTEN Any mutation 156 156 Signature overall 0.41 -0.69 1.42 1386.53 1.00 1327 133 133 23 TRUE 0.35
colorectal cancer KRAS_13 BCOR Any mutation 57 13 Signature 15 -0.55 -2.15 0.80 1587.51 1.00 317 56 12 1 FALSE 0.33
colorectal cancer KRAS_13 BCOR Any mutation 52 27 Signature 1A 0.59 -0.64 1.66 1538.53 1.00 770 48 23 4 FALSE 0.50
colorectal cancer KRAS_13 BCOR Any mutation 40 49 Signature 6 -0.24 -1.22 0.67 1550.43 1.00 241 35 44 5 FALSE 0.21
colorectal cancer KRAS_13 BCOR Any mutation 153 100 Signature overall -0.06 -1.35 1.16 1522.13 1.00 1351 142 89 11 FALSE 0.03
colorectal cancer KRAS_13 CTNNB1 Any mutation 57 22 Signature 15 0.30 -0.85 1.19 1478.25 1.00 310 54 19 3 TRUE 0.26
colorectal cancer KRAS_13 CTNNB1 Any mutation 52 61 Signature 1A 0.98 0.31 1.66 1419.43 1.00 745 42 51 10 TRUE 2.34
colorectal cancer KRAS_13 CTNNB1 Any mutation 38 33 Signature 6 0.75 -0.06 1.51 1344.53 1.00 250 31 26 7 TRUE 1.25
colorectal cancer KRAS_13 CTNNB1 Any mutation 147 116 Signature overall 0.68 -0.25 1.50 1595.41 1.00 1305 127 96 20 TRUE 0.89
colorectal cancer KRAS_13 ARID1A Any mutation 58 39 Signature 15 -0.31 -1.25 0.49 1406.35 1.00 308 54 35 4 TRUE 0.31
colorectal cancer KRAS_13 ARID1A Any mutation 57 130 Signature 1A 0.47 -0.16 1.09 1520.98 1.00 710 43 116 14 TRUE 0.87
colorectal cancer KRAS_13 ARID1A Any mutation 39 99 Signature 6 -0.34 -1.08 0.37 1502.27 1.00 212 31 91 8 TRUE 0.44
colorectal cancer KRAS_13 ARID1A Any mutation 159 281 Signature overall 0.00 -0.88 0.83 1272.69 1.00 1253 131 253 28 TRUE 0.00
colorectal cancer KRAS_13 PIK3R1 Any mutation 57 17 Signature 15 -0.38 -1.76 0.78 1483.03 1.00 316 55 15 2 TRUE 0.25
colorectal cancer KRAS_13 PIK3R1 Any mutation 52 31 Signature 1A -0.16 -1.61 1.06 1355.66 1.00 767 50 29 2 TRUE 0.09
colorectal cancer KRAS_13 PIK3R1 Any mutation 38 31 Signature 6 -0.08 -1.18 0.93 1526.27 1.00 250 34 27 4 TRUE 0.05
colorectal cancer KRAS_13 PIK3R1 Any mutation 151 96 Signature overall -0.26 -1.61 1.05 1298.74 1.00 1354 142 87 9 TRUE 0.16
colorectal cancer KRAS_13 FAT1 Any mutation 11 44 Signature 10 0.47 -0.72 1.72 1430.30 1.00 20 3 36 8 FALSE 0.34
colorectal cancer KRAS_13 FAT1 Any mutation 57 29 Signature 15 -1.14 -2.76 0.18 1399.37 1.00 309 56 28 1 FALSE 0.88
colorectal cancer KRAS_13 FAT1 Any mutation 54 66 Signature 1A 0.94 0.10 1.67 1508.35 1.00 748 44 56 10 FALSE 1.76
colorectal cancer KRAS_13 FAT1 Any mutation 41 67 Signature 6 0.08 -0.72 0.80 1409.05 1.00 229 32 58 9 FALSE 0.08
colorectal cancer KRAS_13 FAT1 Any mutation 163 206 Signature overall 0.10 -1.32 1.46 1446.77 1.00 1306 135 178 28 FALSE 0.05
colorectal cancer KRAS_13 CIC Any mutation 57 19 Signature 15 -0.76 -2.33 0.39 1452.77 1.00 317 56 18 1 TRUE 0.56
colorectal cancer KRAS_13 CIC Any mutation 54 58 Signature 1A 0.38 -0.56 1.19 1323.49 1.00 750 47 51 7 TRUE 0.40
colorectal cancer KRAS_13 CIC Any mutation 38 43 Signature 6 -0.78 -2.07 0.24 1171.17 1.00 243 36 41 2 TRUE 0.72
colorectal cancer KRAS_13 CIC Any mutation 149 120 Signature overall -0.35 -1.64 0.84 1220.74 1.00 1310 139 110 10 TRUE 0.24
colorectal cancer KRAS_13 NCOR1 Any mutation 57 22 Signature 15 0.07 -1.02 1.04 1619.24 1.00 313 53 18 4 FALSE 0.05
colorectal cancer KRAS_13 NCOR1 Any mutation 53 44 Signature 1A -0.06 -1.22 0.88 1410.46 1.00 758 50 41 3 FALSE 0.04
colorectal cancer KRAS_13 NCOR1 Any mutation 39 43 Signature 6 -0.10 -1.06 0.74 1328.33 1.00 244 34 38 5 FALSE 0.08
colorectal cancer KRAS_13 NCOR1 Any mutation 153 125 Signature overall -0.09 -1.33 1.14 1407.32 1.00 1336 140 112 13 FALSE 0.06
colorectal cancer KRAS_13 POLE Any mutation 57 19 Signature 15 -0.74 -2.35 0.60 1462.85 1.00 314 56 18 1 TRUE 0.49
colorectal cancer KRAS_13 POLE Any mutation 54 36 Signature 1A 0.88 -0.14 1.74 1331.81 1.01 766 48 30 6 TRUE 1.18
colorectal cancer KRAS_13 POLE Any mutation 39 54 Signature 6 0.08 -0.81 0.87 1502.20 1.00 235 32 47 7 TRUE 0.07
colorectal cancer KRAS_13 POLE Any mutation 155 129 Signature overall 0.18 -1.12 1.43 1474.77 1.00 1335 138 112 17 TRUE 0.11
colorectal cancer KRAS_13 TGFBR2 Any mutation 57 11 Signature 15 0.13 -1.29 1.18 1553.54 1.00 320 55 9 2 TRUE 0.08
colorectal cancer KRAS_13 TGFBR2 Any mutation 52 48 Signature 1A 0.59 -0.30 1.39 1509.33 1.00 755 46 42 6 TRUE 0.76
colorectal cancer KRAS_13 TGFBR2 Any mutation 38 43 Signature 6 0.04 -0.87 0.92 1367.66 1.00 237 33 38 5 TRUE 0.04
colorectal cancer KRAS_13 TGFBR2 Any mutation 147 102 Signature overall 0.26 -1.01 1.49 1494.09 1.00 1312 134 89 13 TRUE 0.17
colorectal cancer KRAS_13 KMT2A Any mutation 7 22 Signature 10 0.44 -0.86 1.75 1450.91 1.00 24 3 18 4 FALSE 0.31
colorectal cancer KRAS_13 KMT2A Any mutation 58 19 Signature 15 -0.37 -1.69 0.72 1508.74 1.00 313 56 17 2 FALSE 0.25
colorectal cancer KRAS_13 KMT2A Any mutation 54 53 Signature 1A 0.84 0.01 1.61 1506.85 1.00 751 46 45 8 FALSE 1.40
colorectal cancer KRAS_13 KMT2A Any mutation 38 42 Signature 6 -0.78 -2.11 0.28 1406.21 1.00 243 36 40 2 FALSE 0.70
colorectal cancer KRAS_13 KMT2A Any mutation 157 136 Signature overall 0.04 -1.26 1.30 1312.56 1.00 1331 141 120 16 FALSE 0.02
colorectal cancer KRAS_13 BRCA2 Any mutation 7 37 Signature 10 -0.02 -1.44 1.35 1478.25 1.00 22 3 33 4 TRUE 0.01
colorectal cancer KRAS_13 BRCA2 Any mutation 57 17 Signature 15 -0.85 -2.56 0.50 1493.99 1.00 317 56 16 1 TRUE 0.53
colorectal cancer KRAS_13 BRCA2 Any mutation 56 50 Signature 1A 1.23 0.45 1.97 1452.46 1.00 758 46 40 10 TRUE 2.81
colorectal cancer KRAS_13 BRCA2 Any mutation 40 62 Signature 6 -0.48 -1.44 0.38 1451.52 1.00 233 35 57 5 TRUE 0.51
colorectal cancer KRAS_13 BRCA2 Any mutation 160 166 Signature overall -0.06 -1.53 1.36 1456.89 1.00 1330 140 146 20 TRUE 0.03
colorectal cancer KRAS_13 NOTCH3 Any mutation 57 27 Signature 15 -0.06 -0.99 0.85 1200.05 1.00 310 53 23 4 TRUE 0.04
colorectal cancer KRAS_13 NOTCH3 Any mutation 52 70 Signature 1A 0.19 -0.64 1.01 1602.13 1.00 741 46 64 6 TRUE 0.18
colorectal cancer KRAS_13 NOTCH3 Any mutation 39 72 Signature 6 -0.19 -0.97 0.56 1343.23 1.00 227 32 65 7 TRUE 0.20
colorectal cancer KRAS_13 NOTCH3 Any mutation 148 169 Signature overall -0.01 -1.06 1.11 1549.96 1.00 1278 131 152 17 TRUE 0.00
colorectal cancer KRAS_13 NOTCH4 Any mutation 57 18 Signature 15 -0.72 -2.12 0.42 1487.19 1.00 305 56 17 1 TRUE 0.57
colorectal cancer KRAS_13 NOTCH4 Any mutation 50 43 Signature 1A -0.21 -1.35 0.80 1183.13 1.00 736 47 40 3 TRUE 0.15
colorectal cancer KRAS_13 NOTCH4 Any mutation 38 41 Signature 6 -0.38 -1.32 0.52 1538.40 1.00 234 34 37 4 TRUE 0.36
colorectal cancer KRAS_13 NOTCH4 Any mutation 145 102 Signature overall -0.44 -1.59 0.65 1598.77 1.00 1275 137 94 8 TRUE 0.37
colorectal cancer KRAS_13 ERBB3 Any mutation 57 18 Signature 15 0.25 -0.90 1.16 1410.36 1.00 313 54 15 3 TRUE 0.21
colorectal cancer KRAS_13 ERBB3 Any mutation 53 46 Signature 1A 0.91 0.12 1.72 1570.06 1.00 762 45 38 8 TRUE 1.61
colorectal cancer KRAS_13 ERBB3 Any mutation 39 34 Signature 6 0.19 -0.77 1.03 1530.26 1.00 247 35 30 4 TRUE 0.17
colorectal cancer KRAS_13 ERBB3 Any mutation 149 98 Signature overall 0.46 -0.59 1.44 1581.90 1.00 1322 134 83 15 TRUE 0.41
colorectal cancer KRAS_13 SMAD4 Any mutation 57 60 Signature 15 -0.65 -1.47 0.08 1595.07 1.00 278 52 55 5 TRUE 1.01
colorectal cancer KRAS_13 SMAD4 Any mutation 52 122 Signature 1A -0.97 -1.88 -0.14 1523.10 1.00 683 50 120 2 TRUE 1.50
colorectal cancer KRAS_13 SMAD4 Any mutation 8 11 Signature 2 -0.06 -1.17 1.18 1526.08 1.00 66 5 8 3 TRUE 0.04
colorectal cancer KRAS_13 SMAD4 Any mutation 38 57 Signature 6 -0.63 -1.48 0.17 1600.32 1.00 228 34 53 4 TRUE 0.90
colorectal cancer KRAS_13 SMAD4 Any mutation 164 301 Signature overall -0.56 -1.28 0.18 1557.90 1.00 1369 147 284 17 TRUE 0.90
colorectal cancer KRAS_13 ATM Any mutation 9 39 Signature 10 0.26 -0.87 1.49 1487.16 1.00 19 3 33 6 TRUE 0.18
colorectal cancer KRAS_13 ATM Any mutation 58 32 Signature 15 0.40 -0.49 1.20 1511.92 1.00 307 51 25 7 TRUE 0.45
colorectal cancer KRAS_13 ATM Any mutation 53 77 Signature 1A 0.66 -0.09 1.36 1263.03 1.00 734 44 68 9 TRUE 1.12
colorectal cancer KRAS_13 ATM Any mutation 38 48 Signature 6 -0.94 -2.32 0.18 1471.26 1.00 236 36 46 2 TRUE 0.88
colorectal cancer KRAS_13 ATM Any mutation 158 196 Signature overall 0.10 -1.15 1.31 1449.80 1.00 1296 134 172 24 TRUE 0.06
colorectal cancer KRAS_13 KMT2D Any mutation 57 55 Signature 15 -0.92 -2.01 -0.04 1352.12 1.00 299 54 52 3 FALSE 1.17
colorectal cancer KRAS_13 KMT2D Any mutation 55 128 Signature 1A 0.45 -0.23 1.07 1344.19 1.00 722 42 115 13 FALSE 0.73
colorectal cancer KRAS_13 KMT2D Any mutation 43 142 Signature 6 -0.57 -1.29 0.08 1422.27 1.00 199 32 131 11 FALSE 1.00
colorectal cancer KRAS_13 KMT2D Any mutation 160 344 Signature overall -0.31 -1.33 0.70 1488.64 1.00 1240 131 315 29 FALSE 0.27
colorectal cancer KRAS_13 TSC2 Any mutation 57 11 Signature 15 -0.49 -2.12 0.82 1485.97 1.00 318 56 10 1 TRUE 0.29
colorectal cancer KRAS_13 TSC2 Any mutation 53 36 Signature 1A 0.27 -0.94 1.29 1441.13 1.00 767 49 32 4 TRUE 0.20
colorectal cancer KRAS_13 TSC2 Any mutation 38 44 Signature 6 -0.54 -1.75 0.41 1460.04 1.00 241 35 41 3 TRUE 0.48
colorectal cancer KRAS_13 TSC2 Any mutation 148 91 Signature overall -0.24 -1.64 1.07 1331.72 1.00 1326 140 83 8 TRUE 0.14
colorectal cancer KRAS_13 APC Any mutation 14 94 Signature 10 0.69 -0.12 1.55 1351.21 1.00 3 0 80 14 TRUE 1.00
colorectal cancer KRAS_13 APC Any mutation 89 469 Signature 15 0.79 0.24 1.38 1679.43 1.00 76 7 387 82 TRUE 2.11
colorectal cancer KRAS_13 APC Any mutation 74 962 Signature 1A 0.04 -0.47 0.56 1443.48 1.00 206 15 903 59 TRUE 0.06
colorectal cancer KRAS_13 APC Any mutation 13 95 Signature 2 0.42 -0.37 1.21 1617.12 1.00 15 2 84 11 TRUE 0.53
colorectal cancer KRAS_13 APC Any mutation 57 355 Signature 6 0.30 -0.28 0.89 1598.67 1.00 83 12 310 45 TRUE 0.51
colorectal cancer KRAS_13 APC Any mutation 275 2462 Signature overall 0.25 -0.25 0.76 1522.78 1.00 513 38 2225 237 TRUE 0.50
colorectal cancer KRAS_13 ERBB2 Any mutation 53 47 Signature 1A 1.02 0.17 1.78 1490.57 1.00 758 45 39 8 TRUE 1.89
colorectal cancer KRAS_13 ERBB2 Any mutation 38 29 Signature 6 0.42 -0.72 1.34 1422.12 1.00 252 34 25 4 TRUE 0.39
colorectal cancer KRAS_13 ERBB2 Any mutation 91 76 Signature overall 0.71 -0.77 2.04 1535.12 1.00 1010 79 64 12 TRUE 0.49
colorectal cancer KRAS_13 ARID2 Any mutation 57 19 Signature 15 -0.39 -1.71 0.74 1331.42 1.00 314 55 17 2 FALSE 0.28
colorectal cancer KRAS_13 ARID2 Any mutation 53 42 Signature 1A 0.16 -0.97 1.15 1363.79 1.00 759 49 38 4 FALSE 0.12
colorectal cancer KRAS_13 ARID2 Any mutation 38 27 Signature 6 -0.21 -1.42 0.79 1762.60 1.00 251 35 24 3 FALSE 0.15
colorectal cancer KRAS_13 ARID2 Any mutation 152 104 Signature overall -0.19 -1.49 1.04 1288.79 1.00 1344 142 94 10 FALSE 0.12
colorectal cancer KRAS_13 MTOR Any mutation 57 17 Signature 15 0.16 -1.00 1.17 1467.56 1.00 316 54 14 3 TRUE 0.11
colorectal cancer KRAS_13 MTOR Any mutation 53 48 Signature 1A 0.94 0.08 1.74 1378.17 1.00 758 45 40 8 TRUE 1.59
colorectal cancer KRAS_13 MTOR Any mutation 41 45 Signature 6 -0.06 -0.97 0.76 1535.99 1.00 239 36 40 5 TRUE 0.05
colorectal cancer KRAS_13 MTOR Any mutation 155 122 Signature overall 0.28 -0.83 1.25 1408.67 1.00 1337 138 105 17 TRUE 0.22
colorectal cancer KRAS_13 NOTCH1 Any mutation 57 17 Signature 15 -1.81 -4.92 0.04 1542.52 1.00 317 57 17 0 TRUE 0.78
colorectal cancer KRAS_13 NOTCH1 Any mutation 57 47 Signature 1A 1.38 0.60 2.13 1299.02 1.00 759 46 36 11 TRUE 3.43
colorectal cancer KRAS_13 NOTCH1 Any mutation 40 82 Signature 6 -0.49 -1.36 0.30 1508.03 1.00 219 33 75 7 TRUE 0.61
colorectal cancer KRAS_13 NOTCH1 Any mutation 158 157 Signature overall -0.56 -2.57 0.91 1643.23 1.00 1319 140 139 18 TRUE 0.28
colorectal cancer KRAS_13 SETD2 Any mutation 7 22 Signature 10 0.48 -0.85 1.85 1577.89 1.00 21 3 18 4 FALSE 0.31
colorectal cancer KRAS_13 SETD2 Any mutation 58 13 Signature 15 -0.04 -1.47 1.17 1436.58 1.00 318 56 11 2 FALSE 0.02
colorectal cancer KRAS_13 SETD2 Any mutation 52 31 Signature 1A 1.12 0.15 2.00 1493.54 1.00 770 46 25 6 FALSE 1.77
colorectal cancer KRAS_13 SETD2 Any mutation 39 39 Signature 6 -0.46 -1.66 0.51 1504.08 1.00 242 36 36 3 FALSE 0.39
colorectal cancer KRAS_13 SETD2 Any mutation 156 105 Signature overall 0.30 -1.04 1.70 1392.46 1.00 1351 141 90 15 FALSE 0.18
colorectal cancer KRAS_13 EPHA3 Any mutation 6 14 Signature 10 0.55 -0.85 1.90 1509.95 1.00 25 3 11 3 FALSE 0.38
colorectal cancer KRAS_13 EPHA3 Any mutation 57 13 Signature 15 -0.41 -2.05 0.81 1555.98 1.00 316 56 12 1 FALSE 0.24
colorectal cancer KRAS_13 EPHA3 Any mutation 52 42 Signature 1A 0.73 -0.22 1.59 1187.31 1.00 759 46 36 6 FALSE 0.93
colorectal cancer KRAS_13 EPHA3 Any mutation 38 26 Signature 6 -0.36 -1.67 0.81 1458.36 1.00 251 36 24 2 FALSE 0.23
colorectal cancer KRAS_13 EPHA3 Any mutation 153 95 Signature overall 0.13 -1.08 1.25 1463.64 1.00 1351 141 83 12 FALSE 0.08
colorectal cancer KRAS_13 PTCH1 Any mutation 57 14 Signature 15 -0.10 -1.41 1.03 1350.45 1.00 319 55 12 2 TRUE 0.06
colorectal cancer KRAS_13 PTCH1 Any mutation 55 55 Signature 1A 0.88 0.07 1.70 1408.58 1.00 753 46 46 9 TRUE 1.49
colorectal cancer KRAS_13 PTCH1 Any mutation 43 53 Signature 6 0.04 -0.86 0.81 1521.96 1.00 240 36 46 7 TRUE 0.03
colorectal cancer KRAS_13 PTCH1 Any mutation 159 133 Signature overall 0.06 -1.22 1.15 1443.55 1.00 1335 141 115 18 TRUE 0.04
colorectal cancer KRAS_13 TET1 Any mutation 10 27 Signature 10 0.73 -0.54 2.11 1387.73 1.00 20 3 20 7 FALSE 0.55
colorectal cancer KRAS_13 TET1 Any mutation 57 18 Signature 15 -1.08 -3.11 0.42 1496.55 1.00 307 56 17 1 FALSE 0.65
colorectal cancer KRAS_13 TET1 Any mutation 50 25 Signature 1A 1.10 -0.12 2.12 1500.43 1.00 753 45 20 5 FALSE 1.31
colorectal cancer KRAS_13 TET1 Any mutation 37 28 Signature 6 -2.03 -5.11 -0.09 1426.93 1.00 241 37 28 0 FALSE 0.96
colorectal cancer KRAS_13 TET1 Any mutation 154 98 Signature overall -0.32 -2.21 1.40 1406.33 1.00 1321 141 85 13 FALSE 0.14
colorectal cancer KRAS_13 SMAD3 Any mutation 57 21 Signature 15 -0.07 -1.12 0.84 1239.57 1.00 314 54 18 3 TRUE 0.05
colorectal cancer KRAS_13 SMAD3 Any mutation 52 38 Signature 1A 0.14 -0.85 1.09 1402.58 1.00 764 48 34 4 TRUE 0.11
colorectal cancer KRAS_13 SMAD3 Any mutation 38 20 Signature 6 -0.32 -1.68 0.66 1466.32 1.00 255 37 19 1 TRUE 0.23
colorectal cancer KRAS_13 SMAD3 Any mutation 147 79 Signature overall -0.10 -1.16 0.83 1510.57 1.00 1333 139 71 8 TRUE 0.08
colorectal cancer KRAS_13 GRIN2A Any mutation 57 12 Signature 15 -1.40 -3.84 0.22 1402.85 1.00 319 57 12 0 FALSE 0.75
colorectal cancer KRAS_13 GRIN2A Any mutation 52 43 Signature 1A -0.50 -1.92 0.67 1386.08 1.00 753 50 41 2 FALSE 0.34
colorectal cancer KRAS_13 GRIN2A Any mutation 38 43 Signature 6 -0.41 -1.52 0.59 1437.61 1.00 237 34 39 4 FALSE 0.36
colorectal cancer KRAS_13 GRIN2A Any mutation 152 116 Signature overall -0.54 -2.10 0.77 1416.00 1.00 1331 143 107 9 FALSE 0.35
colorectal cancer KRAS_13 ASXL1 Any mutation 57 14 Signature 15 0.16 -1.01 1.23 1421.21 1.00 319 54 11 3 TRUE 0.11
colorectal cancer KRAS_13 ASXL1 Any mutation 52 31 Signature 1A 0.21 -0.92 1.24 1569.60 1.00 767 49 28 3 TRUE 0.15
colorectal cancer KRAS_13 ASXL1 Any mutation 38 34 Signature 6 -0.26 -1.39 0.70 1487.89 1.00 247 35 31 3 TRUE 0.20
colorectal cancer KRAS_13 ASXL1 Any mutation 151 90 Signature overall 0.02 -1.17 1.17 1589.36 1.00 1355 141 80 10 TRUE 0.01
colorectal cancer KRAS_13 EP300 Any mutation 58 18 Signature 15 -0.36 -1.72 0.70 1681.51 1.00 315 56 16 2 TRUE 0.26
colorectal cancer KRAS_13 EP300 Any mutation 52 36 Signature 1A 0.00 -1.22 1.03 1457.82 1.00 762 49 33 3 TRUE 0.00
colorectal cancer KRAS_13 EP300 Any mutation 40 51 Signature 6 -0.27 -1.22 0.56 1436.78 1.00 240 35 46 5 TRUE 0.25
colorectal cancer KRAS_13 EP300 Any mutation 150 105 Signature overall -0.20 -1.42 1.08 1632.93 1.00 1317 140 95 10 TRUE 0.14
colorectal cancer KRAS_13 ERBB4 Any mutation 8 18 Signature 10 0.92 -0.18 2.12 1523.53 1.00 22 3 13 5 TRUE 0.92
colorectal cancer KRAS_13 ERBB4 Any mutation 57 23 Signature 15 0.03 -1.03 0.99 1468.70 1.00 311 54 20 3 TRUE 0.02
colorectal cancer KRAS_13 ERBB4 Any mutation 52 43 Signature 1A 0.60 -0.37 1.46 1411.11 1.00 758 47 38 5 TRUE 0.69
colorectal cancer KRAS_13 ERBB4 Any mutation 40 31 Signature 6 0.51 -0.40 1.34 1612.32 1.00 250 34 25 6 TRUE 0.60
colorectal cancer KRAS_13 ERBB4 Any mutation 157 115 Signature overall 0.50 -0.59 1.50 1473.01 1.00 1341 138 96 19 TRUE 0.45
colorectal cancer KRAS_13 MED12 Any mutation 57 11 Signature 15 -0.81 -3.32 0.77 1573.53 1.00 318 57 11 0 TRUE 0.36
colorectal cancer KRAS_13 MED12 Any mutation 52 34 Signature 1A 0.67 -0.38 1.61 1387.92 1.00 767 47 29 5 TRUE 0.73
colorectal cancer KRAS_13 MED12 Any mutation 41 42 Signature 6 0.31 -0.60 1.10 1489.36 1.00 246 34 35 7 TRUE 0.33
colorectal cancer KRAS_13 MED12 Any mutation 150 87 Signature overall 0.05 -1.63 1.38 1425.82 1.00 1331 138 75 12 TRUE 0.02
colorectal cancer KRAS_13 NF1 Any mutation 7 24 Signature 10 0.19 -1.11 1.54 1440.92 1.00 21 3 20 4 TRUE 0.11
colorectal cancer KRAS_13 NF1 Any mutation 57 21 Signature 15 -1.03 -2.76 0.29 1459.35 1.00 312 56 20 1 TRUE 0.74
colorectal cancer KRAS_13 NF1 Any mutation 52 40 Signature 1A 0.23 -0.94 1.19 1531.87 1.00 762 48 36 4 TRUE 0.17
colorectal cancer KRAS_13 NF1 Any mutation 38 44 Signature 6 -1.00 -2.56 0.16 1608.79 1.00 242 36 42 2 TRUE 0.86
colorectal cancer KRAS_13 NF1 Any mutation 154 129 Signature overall -0.41 -1.72 0.90 1475.35 1.00 1337 143 118 11 TRUE 0.27
colorectal cancer KRAS_13 EPHA5 Any mutation 7 26 Signature 10 -0.16 -1.56 1.15 1462.37 1.00 20 3 22 4 FALSE 0.09
colorectal cancer KRAS_13 EPHA5 Any mutation 57 18 Signature 15 -1.98 -4.45 -0.22 1484.92 1.00 314 57 18 0 FALSE 1.15
colorectal cancer KRAS_13 EPHA5 Any mutation 52 49 Signature 1A -1.30 -3.22 0.16 1381.50 1.00 747 51 48 1 FALSE 0.90
colorectal cancer KRAS_13 EPHA5 Any mutation 38 36 Signature 6 -1.07 -2.58 0.12 1169.40 1.00 244 36 34 2 FALSE 0.91
colorectal cancer KRAS_13 EPHA5 Any mutation 154 129 Signature overall -1.12 -2.72 0.38 1369.12 1.00 1325 147 122 7 FALSE 0.82
colorectal cancer KRAS_13 AR Any mutation 58 21 Signature 15 -0.14 -1.27 0.86 1490.83 1.00 313 55 18 3 TRUE 0.10
colorectal cancer KRAS_13 AR Any mutation 52 33 Signature 1A 0.06 -1.05 1.09 1423.63 1.00 763 49 30 3 TRUE 0.04
colorectal cancer KRAS_13 AR Any mutation 38 37 Signature 6 -0.32 -1.37 0.68 1480.57 1.00 244 35 34 3 TRUE 0.26
colorectal cancer KRAS_13 AR Any mutation 148 91 Signature overall -0.14 -1.22 0.95 1433.10 1.00 1320 139 82 9 TRUE 0.09
colorectal cancer KRAS_13 ROS1 Any mutation 10 30 Signature 10 0.79 -0.53 2.12 1398.62 1.00 20 3 23 7 TRUE 0.61
colorectal cancer KRAS_13 ROS1 Any mutation 52 28 Signature 1A 0.42 -0.95 1.55 1437.96 1.00 770 49 25 3 TRUE 0.30
colorectal cancer KRAS_13 ROS1 Any mutation 38 26 Signature 6 -0.07 -1.38 1.03 1444.83 1.00 250 35 23 3 TRUE 0.04
colorectal cancer KRAS_13 ROS1 Any mutation 100 84 Signature overall 0.37 -1.43 2.06 1647.82 1.00 1040 87 71 13 TRUE 0.17
colorectal cancer KRAS_13 PIK3CG Any mutation 57 17 Signature 15 -1.80 -4.22 0.01 1367.90 1.00 313 57 17 0 FALSE 0.97
colorectal cancer KRAS_13 PIK3CG Any mutation 52 29 Signature 1A -0.36 -1.94 0.97 1099.26 1.00 766 50 27 2 FALSE 0.20
colorectal cancer KRAS_13 PIK3CG Any mutation 39 29 Signature 6 -0.45 -1.74 0.69 1397.68 1.00 249 36 26 3 FALSE 0.33
colorectal cancer KRAS_13 PIK3CG Any mutation 153 97 Signature overall -0.76 -2.34 0.71 1351.35 1.00 1347 146 90 7 FALSE 0.47
colorectal cancer KRAS_13 ARID1B Any mutation 57 22 Signature 15 -0.42 -1.60 0.55 1588.83 1.00 312 55 20 2 TRUE 0.35
colorectal cancer KRAS_13 ARID1B Any mutation 52 53 Signature 1A 0.13 -0.81 1.07 1421.40 1.00 754 47 48 5 TRUE 0.11
colorectal cancer KRAS_13 ARID1B Any mutation 38 46 Signature 6 -0.30 -1.28 0.54 1730.25 1.00 239 34 42 4 TRUE 0.28
colorectal cancer KRAS_13 ARID1B Any mutation 147 121 Signature overall -0.19 -1.32 0.82 1535.42 1.00 1305 136 110 11 TRUE 0.14
colorectal cancer KRAS_13 BRAF Any mutation 57 48 Signature 15 -1.62 -2.89 -0.54 1325.66 1.00 284 55 46 2 TRUE 2.02
colorectal cancer KRAS_13 BRAF Any mutation 52 99 Signature 1A -1.10 -2.28 0.04 1610.90 1.00 701 48 95 4 TRUE 1.19
colorectal cancer KRAS_13 BRAF Any mutation 38 60 Signature 6 -2.24 -4.50 -0.91 1497.15 1.00 219 38 60 0 TRUE 1.87
colorectal cancer KRAS_13 BRAF Any mutation 147 207 Signature overall -1.65 -3.04 -0.50 1444.41 1.00 1204 141 201 6 TRUE 1.89
colorectal cancer KRAS_13 B2M Any mutation 57 20 Signature 15 -0.62 -2.18 0.53 1581.26 1.00 308 56 19 1 FALSE 0.44
colorectal cancer KRAS_13 B2M Any mutation 52 46 Signature 1A 0.59 -0.36 1.43 1684.12 1.00 747 46 40 6 FALSE 0.70
colorectal cancer KRAS_13 B2M Any mutation 40 51 Signature 6 0.10 -0.75 0.88 1436.24 1.00 237 33 44 7 FALSE 0.10
colorectal cancer KRAS_13 B2M Any mutation 154 131 Signature overall 0.05 -1.11 1.17 1456.52 1.00 1316 138 115 16 FALSE 0.03
colorectal cancer KRAS_13 CARD11 Any mutation 57 14 Signature 15 -0.06 -1.28 0.98 1549.26 1.00 316 55 12 2 FALSE 0.04
colorectal cancer KRAS_13 CARD11 Any mutation 53 58 Signature 1A 0.19 -0.70 1.00 1401.58 1.00 744 48 53 5 FALSE 0.18
colorectal cancer KRAS_13 CARD11 Any mutation 40 38 Signature 6 0.08 -0.88 0.90 1359.96 1.00 246 35 33 5 FALSE 0.06
colorectal cancer KRAS_13 CARD11 Any mutation 150 110 Signature overall 0.06 -1.02 1.09 1442.93 1.00 1306 138 98 12 FALSE 0.04
colorectal cancer KRAS_13 SOX9 Any mutation 57 40 Signature 15 1.04 0.37 1.71 1385.68 1.00 304 43 26 14 FALSE 2.52
colorectal cancer KRAS_13 SOX9 Any mutation 53 105 Signature 1A 0.12 -0.65 0.80 1394.42 1.00 702 47 99 6 FALSE 0.12
colorectal cancer KRAS_13 SOX9 Any mutation 40 59 Signature 6 0.51 -0.16 1.17 1470.58 1.00 229 30 49 10 FALSE 0.88
colorectal cancer KRAS_13 SOX9 Any mutation 150 204 Signature overall 0.54 -0.31 1.41 1508.05 1.00 1235 120 174 30 FALSE 0.66
colorectal cancer KRAS_13 SMAD2 Any mutation 57 16 Signature 15 0.02 -1.14 1.01 1663.14 1.00 314 55 14 2 TRUE 0.02
colorectal cancer KRAS_13 SMAD2 Any mutation 53 33 Signature 1A 0.34 -0.58 1.27 1573.53 1.00 768 49 29 4 TRUE 0.32
colorectal cancer KRAS_13 SMAD2 Any mutation 38 17 Signature 6 0.07 -1.00 1.06 1435.47 1.00 260 36 15 2 TRUE 0.05
colorectal cancer KRAS_13 SMAD2 Any mutation 148 66 Signature overall 0.15 -0.91 1.09 1582.09 1.00 1342 140 58 8 TRUE 0.12
colorectal cancer KRAS_13 ZFHX3 Any mutation 7 17 Signature 10 0.35 -0.96 1.64 1582.45 1.00 18 3 13 4 FALSE 0.22
colorectal cancer KRAS_13 ZFHX3 Any mutation 51 31 Signature 15 -0.73 -1.98 0.28 1560.74 1.00 279 49 29 2 FALSE 0.69
colorectal cancer KRAS_13 ZFHX3 Any mutation 51 80 Signature 1A 0.35 -0.44 1.12 1492.82 1.00 686 43 72 8 FALSE 0.42
colorectal cancer KRAS_13 ZFHX3 Any mutation 33 81 Signature 6 -0.79 -1.71 0.12 1431.74 1.00 206 29 77 4 FALSE 1.03
colorectal cancer KRAS_13 ZFHX3 Any mutation 142 209 Signature overall -0.21 -1.34 0.89 1517.31 1.00 1189 124 191 18 FALSE 0.16
colorectal cancer KRAS_13 MGA Any mutation 8 15 Signature 10 0.96 -0.33 2.28 1603.08 1.00 20 3 10 5 FALSE 0.87
colorectal cancer KRAS_13 MGA Any mutation 50 16 Signature 15 -0.10 -1.48 0.97 1285.99 1.00 284 48 14 2 FALSE 0.06
colorectal cancer KRAS_13 MGA Any mutation 49 42 Signature 1A 0.34 -0.74 1.29 1426.39 1.00 706 45 38 4 FALSE 0.29
colorectal cancer KRAS_13 MGA Any mutation 33 36 Signature 6 -0.22 -1.42 0.69 1496.12 1.00 227 30 33 3 FALSE 0.16
colorectal cancer KRAS_13 MGA Any mutation 140 109 Signature overall 0.25 -0.94 1.34 1485.56 1.00 1237 126 95 14 FALSE 0.18
colorectal cancer KRAS_13 KMT2B Any mutation 31 18 Signature 15 0.32 -0.78 1.33 1552.65 1.00 154 27 14 4 FALSE 0.26
colorectal cancer KRAS_13 KMT2B Any mutation 33 64 Signature 1A 0.26 -0.55 1.06 1486.93 1.00 381 27 58 6 FALSE 0.27
colorectal cancer KRAS_13 KMT2B Any mutation 21 86 Signature 6 0.12 -0.73 0.94 1531.22 1.00 109 12 77 9 FALSE 0.11
colorectal cancer KRAS_13 KMT2B Any mutation 85 168 Signature overall 0.21 -1.00 1.35 1539.73 1.00 644 66 149 19 FALSE 0.14
colorectal cancer KRAS_13 TCF7L2 Any mutation 51 48 Signature 15 0.00 -0.68 0.64 1497.58 1.00 260 44 41 7 FALSE 0.00
colorectal cancer KRAS_13 TCF7L2 Any mutation 51 115 Signature 1A 0.07 -0.58 0.68 1253.56 1.00 645 42 106 9 FALSE 0.09
colorectal cancer KRAS_13 TCF7L2 Any mutation 6 12 Signature 2 -0.02 -0.91 0.83 1545.13 1.00 55 5 11 1 FALSE 0.02
colorectal cancer KRAS_13 TCF7L2 Any mutation 34 69 Signature 6 -0.03 -0.72 0.64 1551.00 1.00 201 27 62 7 FALSE 0.03
colorectal cancer KRAS_13 TCF7L2 Any mutation 142 244 Signature overall 0.00 -0.62 0.65 1225.38 1.00 1161 118 220 24 FALSE 0.00
colorectal cancer KRAS_13 ANKRD11 Any mutation 50 17 Signature 15 -0.07 -1.27 0.96 1533.43 1.00 279 47 14 3 FALSE 0.04
colorectal cancer KRAS_13 ANKRD11 Any mutation 47 47 Signature 1A -0.40 -1.69 0.62 1409.23 1.00 682 45 45 2 FALSE 0.30
colorectal cancer KRAS_13 ANKRD11 Any mutation 33 57 Signature 6 -0.12 -1.05 0.69 1447.71 1.00 213 27 51 6 FALSE 0.11
colorectal cancer KRAS_13 ANKRD11 Any mutation 134 133 Signature overall -0.22 -1.31 0.87 1268.48 1.00 1194 122 121 12 FALSE 0.16
colorectal cancer KRAS_13 POLD1 Any mutation 50 15 Signature 15 -0.22 -1.46 0.92 1528.16 1.00 290 48 13 2 TRUE 0.15
colorectal cancer KRAS_13 POLD1 Any mutation 49 43 Signature 1A 0.10 -0.95 1.05 1442.32 1.00 709 45 39 4 TRUE 0.08
colorectal cancer KRAS_13 POLD1 Any mutation 33 44 Signature 6 -0.42 -1.55 0.54 1583.14 1.00 226 30 41 3 TRUE 0.37
colorectal cancer KRAS_13 POLD1 Any mutation 132 102 Signature overall -0.20 -1.38 0.95 1531.69 1.00 1225 123 93 9 TRUE 0.14
colorectal cancer KRAS_13 AMER1 Any mutation 57 34 Signature 15 0.46 -0.29 1.17 1372.48 1.00 301 51 28 6 FALSE 0.67
colorectal cancer KRAS_13 AMER1 Any mutation 56 61 Signature 1A 0.76 0.08 1.43 1231.62 1.00 743 47 52 9 FALSE 1.62
colorectal cancer KRAS_13 AMER1 Any mutation 39 36 Signature 6 0.64 -0.18 1.37 1274.12 1.00 248 32 29 7 FALSE 1.05
colorectal cancer KRAS_13 AMER1 Any mutation 152 131 Signature overall 0.62 -0.13 1.33 1323.02 1.00 1292 130 109 22 FALSE 1.01
melanoma RAS_61 SPEN Any mutation 123 105 Signature 7 -0.79 -1.36 -0.21 139.79 1.03 267 106 88 17 FALSE 2.08
melanoma RAS_61 SPEN Any mutation 123 105 Signature overall -0.70 -4.58 3.55 1485.81 1.00 267 106 88 17 FALSE 0.15
melanoma RAS_61 KMT2C Any mutation 13 11 Signature 11 0.34 -1.02 2.18 10.56 1.14 36 8 6 5 FALSE 0.15
melanoma RAS_61 KMT2C Any mutation 118 126 Signature 7 -0.94 -1.57 -0.44 44.31 1.04 221 101 109 17 FALSE 2.92
melanoma RAS_61 KMT2C Any mutation 131 137 Signature overall -0.31 -2.00 1.93 1002.96 1.01 257 109 115 22 FALSE 0.13
melanoma RAS_61 TP53 Any mutation 13 14 Signature 11 -0.36 -1.25 0.60 1525.18 1.00 33 10 11 3 TRUE 0.37
melanoma RAS_61 TP53 Any mutation 9 14 Signature 1A -0.40 -1.36 0.59 1333.96 1.00 46 7 12 2 TRUE 0.39
melanoma RAS_61 TP53 Any mutation 123 150 Signature 7 -0.45 -0.89 0.01 1358.18 1.00 222 93 120 30 TRUE 1.31
melanoma RAS_61 TP53 Any mutation 145 178 Signature overall -0.40 -1.17 0.42 1394.00 1.00 301 110 143 35 TRUE 0.51
melanoma RAS_61 ATRX Any mutation 125 76 Signature 7 -0.39 -1.00 0.19 1478.73 1.00 284 109 60 16 TRUE 0.68
melanoma RAS_61 ATRX Any mutation 125 76 Signature overall -0.23 -3.98 4.29 1335.56 1.00 284 109 60 16 TRUE 0.04
melanoma RAS_61 PTPRD Any mutation 133 247 Signature 7 -0.67 -1.07 -0.26 1296.96 1.00 202 88 202 45 FALSE 2.77
melanoma RAS_61 PTPRD Any mutation 133 247 Signature overall -0.55 -4.50 3.90 1458.38 1.00 202 88 202 45 FALSE 0.11
melanoma RAS_61 PIK3C2G Any mutation 124 174 Signature 7 -0.47 -0.95 -0.02 635.16 1.00 215 88 138 36 FALSE 1.41
melanoma RAS_61 PIK3C2G Any mutation 124 174 Signature overall -0.35 -4.06 3.72 1380.31 1.00 215 88 138 36 FALSE 0.07
melanoma RAS_61 PTPRT Any mutation 14 12 Signature 11 -0.17 -1.46 1.17 1402.90 1.00 37 11 9 3 FALSE 0.09
melanoma RAS_61 PTPRT Any mutation 138 346 Signature 7 -0.37 -0.74 0.01 1448.34 1.00 177 67 275 71 FALSE 1.24
melanoma RAS_61 PTPRT Any mutation 152 358 Signature overall -0.30 -2.20 1.63 1347.62 1.00 214 78 284 74 FALSE 0.13
melanoma RAS_61 ALK Any mutation 125 117 Signature 7 -0.52 -1.04 -0.02 1048.86 1.00 253 102 94 23 TRUE 1.25
melanoma RAS_61 ALK Any mutation 125 117 Signature overall -0.41 -4.12 3.52 1520.98 1.00 253 102 94 23 TRUE 0.09
melanoma RAS_61 IKZF1 Any mutation 124 93 Signature 7 -0.60 -1.23 -0.05 1117.14 1.00 267 107 76 17 TRUE 1.36
melanoma RAS_61 IKZF1 Any mutation 124 93 Signature overall -0.50 -4.28 3.71 1542.51 1.00 267 107 76 17 TRUE 0.10
melanoma RAS_61 FAT1 Any mutation 123 128 Signature 7 -0.56 -1.07 -0.03 1424.04 1.00 250 99 104 24 FALSE 1.44
melanoma RAS_61 FAT1 Any mutation 123 128 Signature overall -0.46 -4.54 3.74 1492.57 1.00 250 99 104 24 FALSE 0.09
melanoma RAS_61 KMT2A Any mutation 125 124 Signature 7 -0.78 -1.34 -0.26 1288.92 1.00 255 105 104 20 FALSE 2.33
melanoma RAS_61 KMT2A Any mutation 125 124 Signature overall -0.70 -4.99 3.66 1365.54 1.00 255 105 104 20 FALSE 0.14
melanoma RAS_61 PAK7 Any mutation 124 205 Signature 7 -0.73 -1.16 -0.30 1435.03 1.00 184 86 167 38 FALSE 3.12
melanoma RAS_61 PAK7 Any mutation 124 205 Signature overall -0.63 -4.41 3.60 1485.59 1.00 184 86 167 38 FALSE 0.13
melanoma RAS_61 TERT Any mutation 15 48 Signature 11 1.51 0.24 3.01 1501.45 1.00 12 1 34 14 TRUE 1.44
melanoma RAS_61 TERT Any mutation 10 20 Signature 19 2.14 0.61 4.25 1527.76 1.00 7 0 10 10 TRUE 1.67
melanoma RAS_61 TERT Any mutation 9 17 Signature 1A 1.31 0.09 2.55 1290.59 1.00 43 4 12 5 TRUE 1.44
melanoma RAS_61 TERT Any mutation 136 473 Signature 7 0.76 0.12 1.41 1387.87 1.00 61 12 349 124 TRUE 1.66
melanoma RAS_61 TERT Any mutation 170 558 Signature overall 1.41 0.13 2.83 1435.39 1.00 123 17 405 153 TRUE 1.36
melanoma RAS_61 NOTCH3 Any mutation 123 116 Signature 7 -1.09 -1.67 -0.52 1236.14 1.00 250 108 101 15 TRUE 3.67
melanoma RAS_61 NOTCH3 Any mutation 123 116 Signature overall -0.93 -4.60 3.22 1485.95 1.00 250 108 101 15 TRUE 0.21
melanoma RAS_61 NOTCH4 Any mutation 120 141 Signature 7 -0.41 -0.87 0.04 906.14 1.00 223 90 111 30 TRUE 1.20
melanoma RAS_61 NOTCH4 Any mutation 120 141 Signature overall -0.38 -3.95 3.61 1551.11 1.00 223 90 111 30 TRUE 0.08
melanoma RAS_61 CDKN2A Any mutation 127 108 Signature 7 -0.20 -0.68 0.26 1568.37 1.00 250 100 81 27 TRUE 0.36
melanoma RAS_61 CDKN2A Any mutation 127 108 Signature overall -0.24 -4.59 3.95 1379.82 1.00 250 100 81 27 TRUE 0.04
melanoma RAS_61 KMT2D Any mutation 13 13 Signature 11 -0.41 -1.31 0.59 1333.27 1.00 32 10 10 3 FALSE 0.42
melanoma RAS_61 KMT2D Any mutation 134 184 Signature 7 -0.44 -0.84 -0.03 645.99 1.00 241 97 147 37 FALSE 1.51
melanoma RAS_61 KMT2D Any mutation 147 197 Signature overall -0.42 -1.38 0.64 1445.03 1.00 273 107 157 40 FALSE 0.37
colorectal cancer RAS_61 APC Any mutation 20 469 Signature 15 -0.11 -0.93 0.63 1315.88 1.00 77 6 455 14 TRUE 0.11
colorectal cancer RAS_61 APC Any mutation 8 46 Signature 17 0.78 -0.13 1.75 1272.79 1.00 15 0 38 8 TRUE 0.99
colorectal cancer RAS_61 APC Any mutation 50 962 Signature 1A 0.46 -0.16 1.12 1294.15 1.00 216 5 917 45 TRUE 0.82
colorectal cancer RAS_61 APC Any mutation 6 42 Signature 3 0.67 -0.21 1.63 1363.77 1.00 11 0 36 6 TRUE 0.78
colorectal cancer RAS_61 APC Any mutation 16 355 Signature 6 -0.10 -0.91 0.66 1397.09 1.00 89 6 345 10 TRUE 0.10
melanoma RAS_61 APC Any mutation 123 102 Signature 7 -0.74 -1.35 -0.26 32.58 1.07 260 107 86 16 TRUE 1.95
colorectal cancer RAS_61 APC Any mutation 123 2462 Signature overall 0.25 -0.33 0.83 1302.61 1.00 532 19 2358 104 TRUE 0.39
melanoma RAS_61 APC Any mutation 123 102 Signature overall -0.74 -4.47 3.14 1423.93 1.00 260 107 86 16 TRUE 0.18
melanoma RAS_61 ARID2 Any mutation 130 109 Signature 7 0.01 -0.48 0.49 1534.78 1.00 270 100 79 30 FALSE 0.01
melanoma RAS_61 ARID2 Any mutation 130 128 Signature overall -0.68 -5.27 3.52 1467.72 1.00 288 100 98 30 FALSE 0.13
melanoma RAS_61 EPHA3 Any mutation 125 97 Signature 7 0.01 -0.54 0.49 1255.22 1.00 272 99 71 26 FALSE 0.01
melanoma RAS_61 EPHA3 Any mutation 125 97 Signature overall 0.01 -4.61 4.36 1510.08 1.00 272 99 71 26 FALSE 0.00
melanoma RAS_61 KDR Any mutation 123 121 Signature 7 -0.75 -1.31 -0.24 1350.09 1.00 250 103 101 20 TRUE 2.21
melanoma RAS_61 KDR Any mutation 123 121 Signature overall -0.66 -4.57 3.42 1510.15 1.00 250 103 101 20 TRUE 0.14
melanoma RAS_61 NTRK3 Any mutation 126 93 Signature 7 -0.80 -1.39 -0.24 1197.35 1.00 262 111 78 15 FALSE 2.12
melanoma RAS_61 NTRK3 Any mutation 126 93 Signature overall -0.61 -4.84 4.11 1392.21 1.00 262 111 78 15 FALSE 0.12
melanoma RAS_61 GRIN2A Any mutation 13 13 Signature 11 -0.84 -2.12 0.46 1469.01 1.00 32 11 11 2 FALSE 0.73
melanoma RAS_61 GRIN2A Any mutation 134 278 Signature 7 -0.82 -1.21 -0.43 1265.49 1.00 195 88 232 46 FALSE 4.42
melanoma RAS_61 GRIN2A Any mutation 147 291 Signature overall -0.85 -2.27 0.58 1366.56 1.00 227 99 243 48 FALSE 0.61
melanoma RAS_61 ERBB4 Any mutation 125 171 Signature 7 -1.15 -1.66 -0.69 1506.91 1.00 223 103 149 22 TRUE 5.44
melanoma RAS_61 ERBB4 Any mutation 125 171 Signature overall -0.91 -4.93 4.03 1433.43 1.00 223 103 149 22 TRUE 0.18
melanoma RAS_61 NF1 Any mutation 13 17 Signature 11 -1.45 -2.73 -0.11 1551.02 1.00 33 11 15 2 TRUE 1.54
melanoma RAS_61 NF1 Any mutation 126 242 Signature 7 -1.75 -2.26 -1.27 1524.19 1.00 186 105 221 21 TRUE 11.49
melanoma RAS_61 NF1 Any mutation 139 259 Signature overall -1.56 -2.94 0.05 1394.70 1.00 219 116 236 23 TRUE 1.56
melanoma RAS_61 FLT1 Any mutation 125 110 Signature 7 -0.54 -1.08 -0.03 1288.31 1.00 258 104 89 21 FALSE 1.40
melanoma RAS_61 FLT1 Any mutation 125 110 Signature overall -0.47 -4.48 3.66 1400.88 1.00 258 104 89 21 FALSE 0.09
melanoma RAS_61 ROS1 Any mutation 13 11 Signature 11 0.21 -1.10 1.63 1326.47 1.00 35 9 7 4 TRUE 0.12
melanoma RAS_61 ROS1 Any mutation 128 231 Signature 7 -0.77 -1.21 -0.33 1360.41 1.00 211 91 194 37 TRUE 3.49
melanoma RAS_61 ROS1 Any mutation 141 242 Signature overall -0.28 -1.96 1.73 1562.87 1.00 246 100 201 41 TRUE 0.12
melanoma RAS_61 PIK3CG Any mutation 123 92 Signature 7 -1.28 -2.02 -0.60 897.80 1.00 268 113 82 10 FALSE 3.48
melanoma RAS_61 PIK3CG Any mutation 123 92 Signature overall -1.10 -5.51 3.35 1565.59 1.00 268 113 82 10 FALSE 0.25
melanoma RAS_61 BRAF Any mutation 13 25 Signature 11 -2.05 -3.52 -0.77 1492.04 1.00 20 11 23 2 TRUE 2.65
melanoma RAS_61 BRAF Any mutation 9 11 Signature 1A -2.50 -4.85 -0.80 1386.87 1.00 43 9 11 0 TRUE 1.89
melanoma RAS_61 BRAF Any mutation 125 191 Signature 7 -2.15 -2.78 -1.60 1688.86 1.00 163 111 177 14 TRUE 11.99
melanoma RAS_61 BRAF Any mutation 147 227 Signature overall -2.22 -3.78 -0.94 1222.72 1.00 226 131 211 16 TRUE 2.82
melanoma RAS_61 CARD11 Any mutation 123 107 Signature 7 -0.98 -1.59 -0.45 941.72 1.00 252 108 92 15 FALSE 3.19
melanoma RAS_61 CARD11 Any mutation 123 107 Signature overall -0.81 -4.68 3.49 1427.85 1.00 252 108 92 15 FALSE 0.18
melanoma RAS_61 TP63 Any mutation 119 152 Signature 7 -0.54 -1.00 -0.06 1405.63 1.00 212 89 122 30 FALSE 1.58
melanoma RAS_61 TP63 Any mutation 119 152 Signature overall -0.44 -4.42 3.77 1429.88 1.00 212 89 122 30 FALSE 0.08
melanoma RAS_61 ZFHX3 Any mutation 119 90 Signature 7 -0.66 -1.27 -0.08 1492.75 1.00 255 103 74 16 FALSE 1.45
melanoma RAS_61 ZFHX3 Any mutation 119 129 Signature overall -1.38 -6.08 3.16 1488.10 1.00 272 103 113 16 FALSE 0.27
melanoma RAS_61 PREX2 Any mutation 84 158 Signature 7 -0.51 -1.03 -0.01 1113.52 1.00 116 51 125 33 FALSE 1.34
melanoma RAS_61 PREX2 Any mutation 84 158 Signature overall -0.50 -4.83 3.73 1568.19 1.00 116 51 125 33 FALSE 0.10
melanoma RAS_61 EPHA7 Any mutation 120 141 Signature 7 -0.61 -1.10 -0.13 1169.46 1.00 231 94 115 26 FALSE 1.88
melanoma RAS_61 EPHA7 Any mutation 120 141 Signature overall -0.59 -4.69 3.68 1370.94 1.00 231 94 115 26 FALSE 0.12
melanoma NRAS_61 SPEN Any mutation 119 105 Signature 7 -0.88 -1.51 -0.29 772.13 1.01 269 104 90 15 FALSE 2.30
melanoma NRAS_61 SPEN Any mutation 119 105 Signature overall -0.81 -5.06 3.66 1534.92 1.00 269 104 90 15 FALSE 0.17
melanoma NRAS_61 KMT2C Any mutation 13 11 Signature 11 0.54 -0.90 2.14 1208.96 1.00 36 8 6 5 FALSE 0.29
melanoma NRAS_61 KMT2C Any mutation 114 126 Signature 7 -0.93 -1.51 -0.37 1332.90 1.00 225 97 109 17 FALSE 2.88
melanoma NRAS_61 KMT2C Any mutation 127 137 Signature overall -0.17 -1.89 1.91 1475.11 1.00 261 105 115 22 FALSE 0.07
melanoma NRAS_61 TP53 Any mutation 13 14 Signature 11 -0.42 -1.39 0.50 1527.09 1.00 33 10 11 3 TRUE 0.43
melanoma NRAS_61 TP53 Any mutation 8 14 Signature 1A -0.60 -1.68 0.33 1490.38 1.00 46 7 13 1 TRUE 0.59
melanoma NRAS_61 TP53 Any mutation 119 150 Signature 7 -0.49 -0.97 -0.01 1312.91 1.00 225 90 121 29 TRUE 1.37
melanoma NRAS_61 TP53 Any mutation 140 178 Signature overall -0.51 -1.29 0.27 1480.99 1.00 304 107 145 33 TRUE 0.67
melanoma NRAS_61 ATRX Any mutation 120 76 Signature 7 -0.50 -1.19 0.12 1427.14 1.00 287 106 62 14 TRUE 0.88
melanoma NRAS_61 ATRX Any mutation 120 76 Signature overall -0.37 -4.23 4.16 1371.66 1.00 287 106 62 14 TRUE 0.07
melanoma NRAS_61 PTPRD Any mutation 129 247 Signature 7 -0.61 -0.98 -0.19 1275.25 1.00 206 84 202 45 FALSE 2.54
melanoma NRAS_61 PTPRD Any mutation 129 247 Signature overall -0.49 -4.78 3.81 1525.72 1.00 206 84 202 45 FALSE 0.10
melanoma NRAS_61 PIK3C2G Any mutation 119 174 Signature 7 -0.53 -0.99 -0.07 985.59 1.00 217 86 141 33 FALSE 1.65
melanoma NRAS_61 PIK3C2G Any mutation 119 174 Signature overall -0.38 -4.22 4.23 1411.61 1.00 217 86 141 33 FALSE 0.07
melanoma NRAS_61 PTPRT Any mutation 14 12 Signature 11 -0.15 -1.42 1.07 1374.01 1.00 37 11 9 3 FALSE 0.09
melanoma NRAS_61 PTPRT Any mutation 134 346 Signature 7 -0.37 -0.74 0.00 1357.96 1.00 179 65 277 69 FALSE 1.25
melanoma NRAS_61 PTPRT Any mutation 148 358 Signature overall -0.22 -2.05 1.68 1471.51 1.00 216 76 286 72 FALSE 0.09
melanoma NRAS_61 ALK Any mutation 121 117 Signature 7 -0.61 -1.15 -0.10 1546.43 1.00 255 100 96 21 TRUE 1.55
melanoma NRAS_61 ALK Any mutation 121 117 Signature overall -0.50 -4.49 3.96 1406.30 1.00 255 100 96 21 TRUE 0.10
melanoma NRAS_61 IKZF1 Any mutation 120 93 Signature 7 -0.63 -1.26 -0.08 1406.57 1.00 270 104 77 16 TRUE 1.42
melanoma NRAS_61 IKZF1 Any mutation 120 93 Signature overall -0.52 -4.53 3.80 1546.16 1.00 270 104 77 16 TRUE 0.10
melanoma NRAS_61 FAT1 Any mutation 119 128 Signature 7 -0.55 -1.04 -0.08 1227.08 1.01 253 96 105 23 FALSE 1.62
melanoma NRAS_61 FAT1 Any mutation 119 128 Signature overall -0.54 -4.38 3.54 1460.48 1.00 253 96 105 23 FALSE 0.12
melanoma NRAS_61 KMT2A Any mutation 121 124 Signature 7 -0.72 -1.30 -0.22 1213.58 1.00 259 101 104 20 FALSE 2.08
melanoma NRAS_61 KMT2A Any mutation 121 124 Signature overall -0.63 -4.53 4.17 1336.02 1.00 259 101 104 20 FALSE 0.12
melanoma NRAS_61 PAK7 Any mutation 120 205 Signature 7 -0.76 -1.22 -0.36 1372.51 1.00 186 84 169 36 FALSE 3.29
melanoma NRAS_61 PAK7 Any mutation 120 205 Signature overall -0.70 -4.77 3.46 1643.26 1.00 186 84 169 36 FALSE 0.14
melanoma NRAS_61 TERT Any mutation 15 48 Signature 11 1.57 0.18 3.08 1374.80 1.00 12 1 34 14 TRUE 1.50
melanoma NRAS_61 TERT Any mutation 10 20 Signature 19 2.25 0.66 4.26 1495.29 1.00 7 0 10 10 TRUE 1.85
melanoma NRAS_61 TERT Any mutation 8 17 Signature 1A 1.54 0.27 2.92 1557.65 1.00 44 3 12 5 TRUE 1.61
melanoma NRAS_61 TERT Any mutation 132 473 Signature 7 0.73 0.09 1.43 1582.39 1.00 61 12 353 120 TRUE 1.46
melanoma NRAS_61 TERT Any mutation 165 558 Signature overall 1.50 0.18 2.93 1639.97 1.00 124 16 409 149 TRUE 1.50
melanoma NRAS_61 NOTCH3 Any mutation 119 116 Signature 7 -1.05 -1.69 -0.46 1132.46 1.00 254 104 101 15 TRUE 3.17
melanoma NRAS_61 NOTCH3 Any mutation 119 116 Signature overall -0.88 -4.76 3.53 1437.51 1.00 254 104 101 15 TRUE 0.19
melanoma NRAS_61 NOTCH4 Any mutation 116 141 Signature 7 -0.41 -0.90 0.07 1247.35 1.00 226 87 112 29 TRUE 0.96
melanoma NRAS_61 NOTCH4 Any mutation 116 141 Signature overall -0.38 -5.01 3.69 1462.66 1.00 226 87 112 29 TRUE 0.07
melanoma NRAS_61 CDKN2A Any mutation 123 108 Signature 7 -0.20 -0.69 0.30 1310.41 1.00 253 97 82 26 TRUE 0.36
melanoma NRAS_61 CDKN2A Any mutation 123 108 Signature overall -0.11 -4.33 4.32 1262.49 1.00 253 97 82 26 TRUE 0.02
melanoma NRAS_61 KMT2D Any mutation 13 13 Signature 11 -0.38 -1.35 0.58 1468.07 1.00 32 10 10 3 FALSE 0.37
melanoma NRAS_61 KMT2D Any mutation 130 184 Signature 7 -0.40 -0.80 0.01 1475.39 1.00 245 93 147 37 FALSE 1.23
melanoma NRAS_61 KMT2D Any mutation 143 197 Signature overall -0.40 -1.43 0.60 1651.13 1.00 277 103 157 40 FALSE 0.36
melanoma NRAS_61 APC Any mutation 119 102 Signature 7 -0.87 -1.43 -0.28 378.71 1.01 263 104 87 15 TRUE 2.47
melanoma NRAS_61 APC Any mutation 119 102 Signature overall -0.69 -4.13 3.37 1490.19 1.00 263 104 87 15 TRUE 0.16
melanoma NRAS_61 ARID2 Any mutation 126 109 Signature 7 0.06 -0.43 0.54 1550.69 1.00 274 96 79 30 FALSE 0.10
melanoma NRAS_61 ARID2 Any mutation 126 128 Signature overall -0.65 -5.24 3.52 1495.59 1.00 292 96 98 30 FALSE 0.12
melanoma NRAS_61 EPHA3 Any mutation 120 97 Signature 7 -0.14 -0.68 0.39 1442.65 1.00 274 97 74 23 FALSE 0.21
melanoma NRAS_61 EPHA3 Any mutation 120 97 Signature overall -0.14 -4.01 4.15 1272.34 1.00 274 97 74 23 FALSE 0.03
melanoma NRAS_61 KDR Any mutation 119 121 Signature 7 -0.71 -1.26 -0.16 988.97 1.00 254 99 101 20 TRUE 1.99
melanoma NRAS_61 KDR Any mutation 119 121 Signature overall -0.64 -4.65 3.63 1317.01 1.00 254 99 101 20 TRUE 0.13
melanoma NRAS_61 NTRK3 Any mutation 122 93 Signature 7 -0.75 -1.37 -0.20 849.13 1.00 266 107 78 15 FALSE 1.87
melanoma NRAS_61 NTRK3 Any mutation 122 93 Signature overall -0.49 -4.15 4.07 1300.52 1.00 266 107 78 15 FALSE 0.10
melanoma NRAS_61 GRIN2A Any mutation 13 13 Signature 11 -0.87 -2.25 0.42 1177.90 1.00 32 11 11 2 FALSE 0.72
melanoma NRAS_61 GRIN2A Any mutation 130 278 Signature 7 -0.83 -1.26 -0.42 1440.29 1.00 197 86 234 44 FALSE 4.09
melanoma NRAS_61 GRIN2A Any mutation 143 291 Signature overall -0.85 -2.45 0.62 1314.35 1.00 229 97 245 46 FALSE 0.55
melanoma NRAS_61 ERBB4 Any mutation 121 171 Signature 7 -1.24 -1.80 -0.71 1274.40 1.00 225 101 151 20 TRUE 5.18
melanoma NRAS_61 ERBB4 Any mutation 121 171 Signature overall -1.01 -4.84 3.28 1422.40 1.00 225 101 151 20 TRUE 0.22
melanoma NRAS_61 NF1 Any mutation 13 17 Signature 11 -1.49 -2.76 -0.18 1445.93 1.00 33 11 15 2 TRUE 1.63
melanoma NRAS_61 NF1 Any mutation 122 242 Signature 7 -1.76 -2.25 -1.30 727.27 1.01 189 102 222 20 TRUE 11.39
melanoma NRAS_61 NF1 Any mutation 135 259 Signature overall -1.61 -3.03 -0.09 1353.33 1.00 222 113 237 22 TRUE 1.59
melanoma NRAS_61 FLT1 Any mutation 121 110 Signature 7 -0.57 -1.10 -0.04 994.11 1.00 261 101 90 20 FALSE 1.38
melanoma NRAS_61 FLT1 Any mutation 121 110 Signature overall -0.38 -4.37 3.94 1421.67 1.00 261 101 90 20 FALSE 0.07
melanoma NRAS_61 ROS1 Any mutation 13 11 Signature 11 0.17 -1.11 1.71 1285.89 1.00 35 9 7 4 TRUE 0.09
melanoma NRAS_61 ROS1 Any mutation 124 231 Signature 7 -0.81 -1.25 -0.42 1394.15 1.00 213 89 196 35 TRUE 4.00
melanoma NRAS_61 ROS1 Any mutation 137 242 Signature overall -0.28 -1.88 1.81 1455.52 1.00 248 98 203 39 TRUE 0.12
melanoma NRAS_61 PIK3CG Any mutation 119 92 Signature 7 -1.24 -1.99 -0.59 1411.44 1.00 272 109 82 10 FALSE 3.19
melanoma NRAS_61 PIK3CG Any mutation 119 92 Signature overall -1.13 -5.35 3.28 1398.88 1.00 272 109 82 10 FALSE 0.24
melanoma NRAS_61 BRAF Any mutation 13 25 Signature 11 -2.08 -3.53 -0.79 1330.13 1.00 20 11 23 2 TRUE 2.43
melanoma NRAS_61 BRAF Any mutation 8 11 Signature 1A -2.46 -4.78 -0.66 1546.28 1.00 44 8 11 0 TRUE 1.83
melanoma NRAS_61 BRAF Any mutation 121 191 Signature 7 -2.18 -2.79 -1.61 1386.56 1.00 166 108 178 13 TRUE 12.35
melanoma NRAS_61 BRAF Any mutation 142 227 Signature overall -2.21 -3.76 -0.81 1465.93 1.00 230 127 212 15 TRUE 2.59
melanoma NRAS_61 CARD11 Any mutation 119 107 Signature 7 -0.95 -1.52 -0.34 407.65 1.01 256 104 92 15 FALSE 2.75
melanoma NRAS_61 CARD11 Any mutation 119 107 Signature overall -0.87 -4.72 3.14 1415.62 1.00 256 104 92 15 FALSE 0.20
melanoma NRAS_61 TP63 Any mutation 115 152 Signature 7 -0.53 -1.03 -0.06 1096.77 1.00 215 86 123 29 FALSE 1.53
melanoma NRAS_61 TP63 Any mutation 115 152 Signature overall -0.43 -4.81 4.40 1429.46 1.00 215 86 123 29 FALSE 0.08
melanoma NRAS_61 ZFHX3 Any mutation 114 90 Signature 7 -0.78 -1.42 -0.17 1431.37 1.00 258 100 76 14 FALSE 1.85
melanoma NRAS_61 ZFHX3 Any mutation 114 129 Signature overall -1.31 -6.00 3.24 1563.38 1.00 275 100 115 14 FALSE 0.25
melanoma NRAS_61 PREX2 Any mutation 82 158 Signature 7 -0.46 -0.99 0.02 1524.08 1.00 118 49 125 33 FALSE 1.13
melanoma NRAS_61 PREX2 Any mutation 82 158 Signature overall -0.42 -4.31 3.86 1393.32 1.00 118 49 125 33 FALSE 0.08
melanoma NRAS_61 EPHA7 Any mutation 116 141 Signature 7 -0.66 -1.21 -0.16 960.52 1.00 233 92 117 24 FALSE 1.95
melanoma NRAS_61 EPHA7 Any mutation 116 141 Signature overall -0.52 -4.36 3.98 1516.08 1.00 233 92 117 24 FALSE 0.11
cancer of unknown primary RAS_12-61 TP53 Inactivating mutation 30 15 TMB quintile 2 -0.32 -1.20 0.53 1127.14 1.00 75 26 11 4 TRUE 0.33
cancer of unknown primary RAS_12-61 TP53 Inactivating mutation 40 29 TMB quintile 3 -0.21 -0.96 0.54 1439.24 1.00 84 32 21 8 TRUE 0.24
cancer of unknown primary RAS_12-61 TP53 Inactivating mutation 39 29 TMB quintile 4 -0.68 -1.56 0.09 1390.52 1.00 77 35 25 4 TRUE 1.00
cancer of unknown primary RAS_12-61 TP53 Inactivating mutation 47 57 TMB quintile 5 -0.23 -0.81 0.38 1505.64 1.00 99 34 44 13 TRUE 0.32
colorectal cancer RAS_12-61 TP53 Inactivating mutation 28 39 TMB quintile 2 -0.67 -1.38 -0.01 1608.93 1.00 75 23 34 5 TRUE 1.22
colorectal cancer RAS_12-61 TP53 Inactivating mutation 192 146 TMB quintile 3 -0.72 -1.12 -0.35 1248.60 1.00 188 153 107 39 TRUE 3.41
colorectal cancer RAS_12-61 TP53 Inactivating mutation 376 208 TMB quintile 4 -0.35 -0.65 -0.05 1495.91 1.00 296 291 123 85 TRUE 1.64
colorectal cancer RAS_12-61 TP53 Inactivating mutation 340 108 TMB quintile 5 -0.44 -0.83 -0.08 1507.58 1.00 230 291 59 49 TRUE 1.59
colorectal cancer RAS_12-61 TP53 Inactivating mutation 39 31 TMB quintile 6 -0.15 -0.82 0.58 1663.30 1.00 87 29 21 10 TRUE 0.17
non-small cell lung cancer RAS_12-61 TP53 Inactivating mutation 83 49 TMB quintile 2 -0.83 -1.60 -0.13 1408.61 1.00 315 77 43 6 TRUE 1.60
non-small cell lung cancer RAS_12-61 TP53 Inactivating mutation 159 116 TMB quintile 3 -0.98 -1.53 -0.48 1438.76 1.00 370 144 101 15 TRUE 3.69
non-small cell lung cancer RAS_12-61 TP53 Inactivating mutation 268 145 TMB quintile 4 -1.05 -1.48 -0.64 1573.27 1.00 379 242 119 26 TRUE 5.98
non-small cell lung cancer RAS_12-61 TP53 Inactivating mutation 474 346 TMB quintile 5 -0.97 -1.24 -0.69 1589.15 1.00 493 395 267 79 TRUE 11.69
pancreatic cancer RAS_12-61 TP53 Inactivating mutation 277 72 TMB quintile 2 1.49 0.86 2.12 1426.36 1.00 65 209 4 68 TRUE 5.11
pancreatic cancer RAS_12-61 TP53 Inactivating mutation 458 131 TMB quintile 3 1.59 1.01 2.27 1402.70 1.00 62 331 4 127 TRUE 6.04
pancreatic cancer RAS_12-61 TP53 Inactivating mutation 241 74 TMB quintile 4 1.48 0.86 2.15 1176.63 1.00 35 172 5 69 TRUE 5.02
pancreatic cancer RAS_12-61 TP53 Inactivating mutation 38 14 TMB quintile 5 1.50 0.80 2.27 1404.33 1.00 16 26 2 12 TRUE 4.19
uterine cancer RAS_12-61 TP53 Inactivating mutation 14 21 TMB quintile 2 -0.61 -1.78 0.55 1483.64 1.00 112 12 19 2 TRUE 0.52
uterine cancer RAS_12-61 TP53 Inactivating mutation 26 38 TMB quintile 3 -0.86 -1.92 0.11 1418.73 1.00 180 24 36 2 TRUE 1.02
uterine cancer RAS_12-61 TP53 Inactivating mutation 48 33 TMB quintile 4 -1.06 -2.13 -0.18 1647.21 1.00 151 46 31 2 TRUE 1.44
uterine cancer RAS_12-61 TP53 Inactivating mutation 71 19 TMB quintile 5 -0.49 -1.47 0.44 1423.39 1.00 179 66 14 5 TRUE 0.51
cancer of unknown primary RAS_12-61 TP53 Inactivating mutation 160 144 TMB overall -0.35 -1.03 0.34 1390.90 1.00 340 129 113 31 TRUE 0.50
colorectal cancer RAS_12-61 TP53 Inactivating mutation 975 532 TMB overall -0.47 -0.98 0.03 1360.69 1.00 876 787 344 188 TRUE 1.17
non-small cell lung cancer RAS_12-61 TP53 Inactivating mutation 984 656 TMB overall -0.95 -1.56 -0.35 1344.15 1.00 1557 858 530 126 TRUE 2.62
pancreatic cancer RAS_12-61 TP53 Inactivating mutation 1014 291 TMB overall 1.51 0.91 2.14 1354.66 1.00 178 738 15 276 TRUE 5.42
uterine cancer RAS_12-61 TP53 Inactivating mutation 159 111 TMB overall -0.74 -1.66 0.12 1537.57 1.00 622 148 100 11 TRUE 1.03
colorectal cancer RAS_12-61 FBXW7 Inactivating mutation 192 11 TMB quintile 3 -0.42 -1.44 0.54 1298.30 1.00 287 189 8 3 TRUE 0.40
colorectal cancer RAS_12-61 FBXW7 Inactivating mutation 375 27 TMB quintile 4 -0.37 -1.13 0.34 1276.20 1.00 400 365 17 10 TRUE 0.49
colorectal cancer RAS_12-61 FBXW7 Inactivating mutation 341 49 TMB quintile 5 0.43 -0.09 1.00 1491.92 1.00 271 309 17 32 TRUE 0.90
colorectal cancer RAS_12-61 FBXW7 Inactivating mutation 37 24 TMB quintile 6 0.32 -0.54 1.13 1488.52 1.00 89 29 16 8 TRUE 0.35
colorectal cancer RAS_12-61 FBXW7 Inactivating mutation 945 111 TMB overall -0.02 -0.88 0.89 1387.72 1.00 1047 892 58 53 TRUE 0.02
non-small cell lung cancer RAS_12-61 SMARCA4 Inactivating mutation 159 12 TMB quintile 3 1.18 0.14 2.31 1504.31 1.00 463 151 4 8 FALSE 1.44
non-small cell lung cancer RAS_12-61 SMARCA4 Inactivating mutation 267 28 TMB quintile 4 0.46 -0.26 1.12 1465.42 1.00 480 254 15 13 FALSE 0.68
non-small cell lung cancer RAS_12-61 SMARCA4 Inactivating mutation 476 94 TMB quintile 5 -0.25 -0.71 0.21 1394.63 1.00 686 446 64 30 FALSE 0.54
non-small cell lung cancer RAS_12-61 SMARCA4 Inactivating mutation 902 134 TMB overall 0.45 -0.73 1.75 1429.22 1.00 1629 851 83 51 FALSE 0.33
colorectal cancer RAS_12-61 PTEN Inactivating mutation 375 17 TMB quintile 4 0.24 -0.70 1.19 1488.68 1.00 410 365 7 10 TRUE 0.22
colorectal cancer RAS_12-61 PTEN Inactivating mutation 340 44 TMB quintile 5 -0.93 -1.57 -0.30 1383.49 1.00 266 326 30 14 TRUE 2.34
colorectal cancer RAS_12-61 PTEN Inactivating mutation 43 57 TMB quintile 6 0.20 -0.51 0.92 1461.88 1.00 76 26 40 17 TRUE 0.23
uterine cancer RAS_12-61 PTEN Inactivating mutation 27 35 TMB quintile 3 -0.05 -1.04 0.80 1482.87 1.00 188 23 31 4 TRUE 0.04
uterine cancer RAS_12-61 PTEN Inactivating mutation 51 72 TMB quintile 4 0.10 -0.54 0.71 1432.89 1.00 138 35 56 16 TRUE 0.12
uterine cancer RAS_12-61 PTEN Inactivating mutation 87 190 TMB quintile 5 0.38 -0.11 0.89 1435.67 1.00 93 29 132 58 TRUE 0.89
uterine cancer RAS_12-61 PTEN Inactivating mutation 10 41 TMB quintile 6 -0.20 -1.24 0.87 1668.34 1.00 25 5 36 5 TRUE 0.14
colorectal cancer RAS_12-61 PTEN Inactivating mutation 758 118 TMB overall -0.14 -1.80 1.64 1448.03 1.00 752 717 77 41 TRUE 0.06
uterine cancer RAS_12-61 PTEN Inactivating mutation 175 338 TMB overall 0.05 -0.88 0.93 1458.54 1.00 444 92 255 83 TRUE 0.04
colorectal cancer RAS_12-61 ARID1A Inactivating mutation 376 24 TMB quintile 4 -0.37 -1.19 0.41 1342.39 1.00 402 366 14 10 TRUE 0.43
colorectal cancer RAS_12-61 ARID1A Inactivating mutation 340 87 TMB quintile 5 -0.88 -1.36 -0.42 1521.36 1.00 243 310 57 30 TRUE 3.57
colorectal cancer RAS_12-61 ARID1A Inactivating mutation 45 96 TMB quintile 6 -0.18 -0.86 0.48 1542.58 1.00 54 21 72 24 TRUE 0.23
non-small cell lung cancer RAS_12-61 ARID1A Inactivating mutation 267 34 TMB quintile 4 -0.30 -0.96 0.32 1472.60 1.00 472 257 24 10 TRUE 0.45
non-small cell lung cancer RAS_12-61 ARID1A Inactivating mutation 478 103 TMB quintile 5 -0.17 -0.57 0.22 1107.40 1.00 684 442 67 36 TRUE 0.41
pancreatic cancer RAS_12-61 ARID1A Inactivating mutation 277 13 TMB quintile 2 -0.81 -1.64 0.05 1666.36 1.00 64 269 5 8 TRUE 1.22
pancreatic cancer RAS_12-61 ARID1A Inactivating mutation 458 42 TMB quintile 3 -0.15 -0.84 0.62 1436.63 1.00 61 421 5 37 TRUE 0.16
pancreatic cancer RAS_12-61 ARID1A Inactivating mutation 243 39 TMB quintile 4 -0.21 -0.96 0.55 1523.11 1.00 33 211 7 32 TRUE 0.23
pancreatic cancer RAS_12-61 ARID1A Inactivating mutation 39 14 TMB quintile 5 -0.08 -1.05 0.89 1389.33 1.00 14 30 5 9 TRUE 0.06
uterine cancer RAS_12-61 ARID1A Inactivating mutation 26 26 TMB quintile 3 0.45 -0.70 1.47 1575.85 1.00 194 22 22 4 TRUE 0.37
uterine cancer RAS_12-61 ARID1A Inactivating mutation 51 69 TMB quintile 4 1.00 0.35 1.63 1256.88 1.00 141 27 45 24 TRUE 2.70
uterine cancer RAS_12-61 ARID1A Inactivating mutation 95 284 TMB quintile 5 0.42 -0.16 1.06 1562.78 1.00 57 16 205 79 TRUE 0.75
uterine cancer RAS_12-61 ARID1A Inactivating mutation 17 75 TMB quintile 6 1.62 0.13 3.66 1431.71 1.00 12 0 58 17 TRUE 1.11
colorectal cancer RAS_12-61 ARID1A Inactivating mutation 761 207 TMB overall -0.48 -2.06 1.13 1404.58 1.00 699 697 143 64 TRUE 0.26
non-small cell lung cancer RAS_12-61 ARID1A Inactivating mutation 745 137 TMB overall -0.23 -1.21 0.74 1357.30 1.00 1156 699 91 46 TRUE 0.19
pancreatic cancer RAS_12-61 ARID1A Inactivating mutation 1017 108 TMB overall -0.30 -1.12 0.57 1574.88 1.00 172 931 22 86 TRUE 0.32
uterine cancer RAS_12-61 ARID1A Inactivating mutation 189 454 TMB overall 0.85 -0.70 2.30 1269.51 1.00 404 65 330 124 TRUE 0.58
uterine cancer RAS_12-61 PIK3R1 Inactivating mutation 26 13 TMB quintile 3 -1.20 -3.73 0.33 1571.80 1.00 202 26 13 0 TRUE 0.63
uterine cancer RAS_12-61 PIK3R1 Inactivating mutation 49 32 TMB quintile 4 -0.71 -1.77 0.20 1397.74 1.00 156 45 28 4 TRUE 0.78
uterine cancer RAS_12-61 PIK3R1 Inactivating mutation 77 57 TMB quintile 5 0.49 -0.10 1.05 1565.01 1.00 164 55 35 22 TRUE 0.97
uterine cancer RAS_12-61 PIK3R1 Inactivating mutation 10 14 TMB quintile 6 -1.38 -3.80 0.16 1341.01 1.00 39 10 14 0 TRUE 0.73
uterine cancer RAS_12-61 PIK3R1 Inactivating mutation 162 116 TMB overall -0.68 -2.24 0.43 1564.29 1.00 561 136 90 26 TRUE 0.50
pancreatic cancer RAS_12-61 SMAD4 Inactivating mutation 277 18 TMB quintile 2 1.16 0.08 2.62 1355.77 1.00 69 259 0 18 TRUE 1.18
pancreatic cancer RAS_12-61 SMAD4 Inactivating mutation 459 78 TMB quintile 3 0.88 0.11 1.72 1483.99 1.00 59 388 7 71 TRUE 1.51
pancreatic cancer RAS_12-61 SMAD4 Inactivating mutation 241 44 TMB quintile 4 1.36 0.40 2.41 1528.64 1.00 38 199 2 42 TRUE 2.07
pancreatic cancer RAS_12-61 SMAD4 Inactivating mutation 39 13 TMB quintile 5 1.64 0.56 2.92 1433.18 1.00 17 27 1 12 TRUE 2.13
pancreatic cancer RAS_12-61 SMAD4 Inactivating mutation 1016 153 TMB overall 1.24 0.30 2.36 1245.02 1.00 183 873 10 143 TRUE 1.72
non-small cell lung cancer RAS_12-61 RB1 Inactivating mutation 159 28 TMB quintile 3 -1.46 -2.50 -0.66 1472.91 1.00 440 158 27 1 TRUE 2.82
non-small cell lung cancer RAS_12-61 RB1 Inactivating mutation 267 40 TMB quintile 4 -1.22 -1.92 -0.56 1410.95 1.00 461 261 34 6 TRUE 3.26
non-small cell lung cancer RAS_12-61 RB1 Inactivating mutation 474 86 TMB quintile 5 -1.08 -1.59 -0.61 1446.03 1.00 682 457 69 17 TRUE 4.54
non-small cell lung cancer RAS_12-61 RB1 Inactivating mutation 900 154 TMB overall -1.24 -2.01 -0.61 1473.03 1.00 1583 876 130 24 TRUE 3.32
uterine cancer RAS_12-61 JAK1 Inactivating mutation 74 76 TMB quintile 5 0.17 -0.39 0.70 1492.44 1.00 153 53 55 21 TRUE 0.26
uterine cancer RAS_12-61 JAK1 Inactivating mutation 12 25 TMB quintile 6 0.56 -0.38 1.72 1354.50 1.00 37 5 18 7 TRUE 0.52
uterine cancer RAS_12-61 JAK1 Inactivating mutation 86 101 TMB overall 0.37 -0.80 1.76 1410.97 1.00 190 58 73 28 TRUE 0.25
uterine cancer RAS_12-61 CTCF Inactivating mutation 72 83 TMB quintile 5 -0.01 -0.58 0.53 1204.66 1.00 132 50 61 22 FALSE 0.01
uterine cancer RAS_12-61 CTCF Inactivating mutation 11 26 TMB quintile 6 0.23 -0.64 1.35 1433.48 1.00 33 5 20 6 FALSE 0.18
uterine cancer RAS_12-61 CTCF Inactivating mutation 83 109 TMB overall 0.10 -1.05 1.35 1366.72 1.00 165 55 81 28 FALSE 0.07
melanoma RAS_12-61 NF1 Inactivating mutation 17 11 TMB quintile 3 -0.81 -2.68 0.84 1591.51 1.00 84 16 10 1 TRUE 0.43
melanoma RAS_12-61 NF1 Inactivating mutation 163 117 TMB quintile 5 -1.13 -1.66 -0.62 1588.33 1.00 170 139 93 24 TRUE 4.77
melanoma RAS_12-61 NF1 Inactivating mutation 14 68 TMB quintile 6 0.45 -0.74 1.78 1224.52 1.00 21 2 56 12 TRUE 0.31
non-small cell lung cancer RAS_12-61 NF1 Inactivating mutation 159 18 TMB quintile 3 -1.45 -2.76 -0.39 1509.88 1.00 450 158 17 1 TRUE 1.73
non-small cell lung cancer RAS_12-61 NF1 Inactivating mutation 267 48 TMB quintile 4 -1.44 -2.26 -0.67 1432.72 1.00 460 262 43 5 TRUE 3.45
non-small cell lung cancer RAS_12-61 NF1 Inactivating mutation 476 108 TMB quintile 5 -0.70 -1.18 -0.27 1343.94 1.00 679 448 80 28 TRUE 2.66
melanoma RAS_12-61 NF1 Inactivating mutation 194 196 TMB overall -0.44 -2.23 1.50 1545.92 1.00 275 157 159 37 TRUE 0.19
non-small cell lung cancer RAS_12-61 NF1 Inactivating mutation 902 174 TMB overall -1.17 -2.18 -0.17 1542.43 1.00 1589 868 140 34 TRUE 1.74
colorectal cancer RAS_12-61 APC Inactivating mutation 29 77 TMB quintile 2 -0.73 -1.41 -0.08 1243.85 1.00 49 19 67 10 TRUE 1.41
colorectal cancer RAS_12-61 APC Inactivating mutation 226 422 TMB quintile 3 -0.39 -0.76 -0.05 1279.21 1.00 86 76 272 150 TRUE 1.46
colorectal cancer RAS_12-61 APC Inactivating mutation 523 936 TMB quintile 4 0.14 -0.19 0.46 1256.67 1.00 85 72 485 451 TRUE 0.40
colorectal cancer RAS_12-61 APC Inactivating mutation 545 781 TMB quintile 5 0.95 0.61 1.29 1477.73 1.00 103 61 297 484 TRUE 7.66
colorectal cancer RAS_12-61 APC Inactivating mutation 62 151 TMB quintile 6 0.36 -0.18 0.97 1502.13 1.00 54 14 103 48 TRUE 0.67
colorectal cancer RAS_12-61 APC Inactivating mutation 1385 2367 TMB overall 0.07 -0.56 0.66 1482.21 1.00 377 242 1224 1143 TRUE 0.09
colorectal cancer RAS_12-61 KMT2D Inactivating mutation 340 46 TMB quintile 5 -1.27 -1.96 -0.65 1334.30 1.00 263 328 34 12 FALSE 3.85
colorectal cancer RAS_12-61 KMT2D Inactivating mutation 46 111 TMB quintile 6 -0.38 -1.01 0.26 1420.33 1.00 46 20 85 26 FALSE 0.60
uterine cancer RAS_12-61 KMT2D Inactivating mutation 71 88 TMB quintile 5 -0.68 -1.32 -0.11 481.65 1.00 128 55 72 16 FALSE 1.57
uterine cancer RAS_12-61 KMT2D Inactivating mutation 11 29 TMB quintile 6 -0.80 -1.89 0.10 945.73 1.00 31 8 26 3 FALSE 0.95
colorectal cancer RAS_12-61 KMT2D Inactivating mutation 386 157 TMB overall -0.74 -3.28 1.92 1323.48 1.00 309 348 119 38 FALSE 0.26
uterine cancer RAS_12-61 KMT2D Inactivating mutation 82 117 TMB overall -0.72 -1.84 0.35 1050.30 1.00 159 63 98 19 FALSE 0.71
non-small cell lung cancer RAS_12-61 SETD2 Inactivating mutation 160 16 TMB quintile 3 -0.23 -1.26 0.54 1566.60 1.00 456 158 14 2 FALSE 0.20
non-small cell lung cancer RAS_12-61 SETD2 Inactivating mutation 267 34 TMB quintile 4 0.02 -0.62 0.64 1419.44 1.00 476 256 23 11 FALSE 0.03
non-small cell lung cancer RAS_12-61 SETD2 Inactivating mutation 479 50 TMB quintile 5 0.51 0.00 1.05 1499.48 1.00 730 451 22 28 FALSE 1.24
non-small cell lung cancer RAS_12-61 SETD2 Inactivating mutation 906 100 TMB overall 0.09 -0.70 0.76 1475.17 1.00 1662 865 59 41 FALSE 0.09
non-small cell lung cancer RAS_12-61 RBM10 Inactivating mutation 83 26 TMB quintile 2 0.53 -0.14 1.14 1436.43 1.00 338 77 20 6 FALSE 1.04
non-small cell lung cancer RAS_12-61 RBM10 Inactivating mutation 159 40 TMB quintile 3 0.60 0.07 1.09 1279.11 1.00 441 145 26 14 FALSE 1.63
non-small cell lung cancer RAS_12-61 RBM10 Inactivating mutation 268 76 TMB quintile 4 0.91 0.47 1.30 1398.48 1.00 461 226 34 42 FALSE 4.81
non-small cell lung cancer RAS_12-61 RBM10 Inactivating mutation 477 133 TMB quintile 5 1.06 0.73 1.41 1486.90 1.00 702 393 49 84 FALSE 9.11
non-small cell lung cancer RAS_12-61 RBM10 Inactivating mutation 987 275 TMB overall 0.78 0.32 1.25 1500.91 1.00 1942 841 129 146 FALSE 2.81
non-small cell lung cancer RAS_12-61 CDKN2A Inactivating mutation 159 17 TMB quintile 3 0.07 -0.90 1.03 1401.67 1.00 456 153 11 6 TRUE 0.05
non-small cell lung cancer RAS_12-61 CDKN2A Inactivating mutation 267 27 TMB quintile 4 -0.22 -0.98 0.54 1347.91 1.00 477 258 18 9 TRUE 0.26
non-small cell lung cancer RAS_12-61 CDKN2A Inactivating mutation 475 96 TMB quintile 5 -0.90 -1.41 -0.44 1288.95 1.00 674 456 77 19 TRUE 3.40
pancreatic cancer RAS_12-61 CDKN2A Inactivating mutation 277 25 TMB quintile 2 1.43 0.47 2.67 1386.27 1.00 68 253 1 24 TRUE 1.91
pancreatic cancer RAS_12-61 CDKN2A Inactivating mutation 460 102 TMB quintile 3 2.07 1.12 3.31 1571.14 1.00 65 359 1 101 TRUE 3.55
pancreatic cancer RAS_12-61 CDKN2A Inactivating mutation 245 63 TMB quintile 4 1.49 0.44 2.54 1279.69 1.00 35 187 5 58 TRUE 2.31
non-small cell lung cancer RAS_12-61 CDKN2A Inactivating mutation 901 140 TMB overall -0.37 -1.30 0.60 1449.19 1.00 1607 867 106 34 TRUE 0.34
pancreatic cancer RAS_12-61 CDKN2A Inactivating mutation 982 190 TMB overall 1.64 0.50 2.88 1348.18 1.00 168 799 7 183 TRUE 2.16
colorectal cancer RAS_12-61 SOX9 Inactivating mutation 192 14 TMB quintile 3 -0.47 -1.42 0.40 1503.17 1.00 285 188 10 4 FALSE 0.49
colorectal cancer RAS_12-61 SOX9 Inactivating mutation 376 73 TMB quintile 4 0.28 -0.19 0.73 1433.60 1.00 383 336 33 40 FALSE 0.63
colorectal cancer RAS_12-61 SOX9 Inactivating mutation 342 88 TMB quintile 5 0.09 -0.35 0.51 1460.04 1.00 252 293 39 49 FALSE 0.15
colorectal cancer RAS_12-61 SOX9 Inactivating mutation 38 43 TMB quintile 6 0.27 -0.50 0.99 1495.29 1.00 79 25 30 13 FALSE 0.34
colorectal cancer RAS_12-61 SOX9 Inactivating mutation 948 218 TMB overall 0.04 -0.91 0.92 1453.53 1.00 999 842 112 106 FALSE 0.03
non-small cell lung cancer RAS_12-61 STK11 Inactivating mutation 161 59 TMB quintile 3 1.27 0.79 1.75 1365.48 1.00 441 128 26 33 TRUE 6.19
non-small cell lung cancer RAS_12-61 STK11 Inactivating mutation 267 106 TMB quintile 4 1.21 0.81 1.63 1575.42 1.00 454 202 41 65 TRUE 8.45
non-small cell lung cancer RAS_12-61 STK11 Inactivating mutation 475 183 TMB quintile 5 0.44 0.11 0.76 1136.01 1.00 651 391 99 84 TRUE 2.14
non-small cell lung cancer RAS_12-61 STK11 Inactivating mutation 903 348 TMB overall 0.97 0.25 1.65 1551.74 1.00 1546 721 166 182 TRUE 2.19
non-small cell lung cancer RAS_12-61 KEAP1 Inactivating mutation 267 35 TMB quintile 4 0.75 0.08 1.52 1075.22 1.00 481 246 14 21 FALSE 1.38
non-small cell lung cancer RAS_12-61 KEAP1 Inactivating mutation 474 69 TMB quintile 5 0.10 -0.42 0.61 1206.02 1.00 706 448 43 26 FALSE 0.16
non-small cell lung cancer RAS_12-61 KEAP1 Inactivating mutation 741 104 TMB overall 0.42 -0.61 1.69 1483.16 1.00 1187 694 57 47 FALSE 0.34
colorectal cancer RAS_12-61 RNF43 Inactivating mutation 375 21 TMB quintile 4 -0.94 -1.89 -0.06 1613.22 1.00 402 369 15 6 TRUE 1.33
colorectal cancer RAS_12-61 RNF43 Inactivating mutation 342 58 TMB quintile 5 -1.44 -2.07 -0.86 1542.02 1.00 249 328 44 14 TRUE 5.32
colorectal cancer RAS_12-61 RNF43 Inactivating mutation 43 113 TMB quintile 6 -0.56 -1.21 0.16 1537.21 1.00 41 19 89 24 TRUE 0.96
colorectal cancer RAS_12-61 RNF43 Inactivating mutation 760 192 TMB overall -0.95 -2.86 0.85 1543.91 1.00 692 716 148 44 TRUE 0.52
colorectal cancer RAS_12-61 B2M Inactivating mutation 324 45 TMB quintile 5 -0.90 -1.53 -0.28 1616.86 1.00 250 309 30 15 FALSE 2.39
colorectal cancer RAS_12-61 B2M Inactivating mutation 45 66 TMB quintile 6 0.33 -0.35 1.01 1412.93 1.00 69 23 44 22 FALSE 0.47
colorectal cancer RAS_12-61 B2M Inactivating mutation 369 111 TMB overall -0.28 -2.50 1.96 1638.86 1.00 319 332 74 37 FALSE 0.10
colorectal cancer RAS_12-61 TCF7L2 Inactivating mutation 177 13 TMB quintile 3 -0.22 -1.16 0.69 1366.08 1.00 254 172 8 5 FALSE 0.19
colorectal cancer RAS_12-61 TCF7L2 Inactivating mutation 342 39 TMB quintile 4 0.09 -0.52 0.70 1407.60 1.00 359 322 19 20 FALSE 0.11
colorectal cancer RAS_12-61 TCF7L2 Inactivating mutation 314 57 TMB quintile 5 -0.34 -0.90 0.18 1449.32 1.00 235 288 31 26 FALSE 0.68
colorectal cancer RAS_12-61 TCF7L2 Inactivating mutation 36 48 TMB quintile 6 0.19 -0.52 0.91 1401.26 1.00 66 22 34 14 FALSE 0.22
colorectal cancer RAS_12-61 TCF7L2 Inactivating mutation 869 157 TMB overall -0.07 -1.02 0.94 1358.49 1.00 914 804 92 65 FALSE 0.05
non-small cell lung cancer RAS_12-61 MGA Inactivating mutation 249 16 TMB quintile 4 0.55 -0.28 1.50 1432.88 1.00 422 240 7 9 FALSE 0.65
non-small cell lung cancer RAS_12-61 MGA Inactivating mutation 435 73 TMB quintile 5 0.32 -0.15 0.82 1527.40 1.00 631 402 40 33 FALSE 0.71
non-small cell lung cancer RAS_12-61 MGA Inactivating mutation 684 89 TMB overall 0.45 -0.92 2.02 1376.64 1.00 1053 642 47 42 FALSE 0.29
uterine cancer RAS_12-61 ZFHX3 Inactivating mutation 44 12 TMB quintile 4 -0.37 -1.65 0.74 1236.48 1.00 151 42 10 2 FALSE 0.25
uterine cancer RAS_12-61 ZFHX3 Inactivating mutation 68 66 TMB quintile 5 0.05 -0.59 0.63 1277.62 1.00 142 50 48 18 FALSE 0.06
uterine cancer RAS_12-61 ZFHX3 Inactivating mutation 12 26 TMB quintile 6 0.07 -1.07 1.11 1507.58 1.00 33 7 21 5 FALSE 0.05
uterine cancer RAS_12-61 ZFHX3 Inactivating mutation 124 104 TMB overall -0.09 -1.42 1.16 1342.08 1.00 326 99 79 25 FALSE 0.05
colorectal cancer RAS_12-61 AMER1 Inactivating mutation 375 31 TMB quintile 4 1.31 0.52 2.20 1473.20 1.00 410 350 6 25 FALSE 2.74
colorectal cancer RAS_12-61 AMER1 Inactivating mutation 338 47 TMB quintile 5 0.78 0.21 1.43 1495.59 1.00 274 305 14 33 FALSE 1.92
colorectal cancer RAS_12-61 AMER1 Inactivating mutation 37 27 TMB quintile 6 0.75 -0.11 1.60 1486.72 1.00 87 27 17 10 FALSE 1.08
colorectal cancer RAS_12-61 AMER1 Inactivating mutation 750 105 TMB overall 0.92 -0.40 2.22 1587.41 1.00 771 682 37 68 FALSE 0.80
cancer of unknown primary KRAS_12-61 TP53 Inactivating mutation 29 15 TMB quintile 2 -0.25 -1.14 0.61 1379.29 1.00 76 25 11 4 TRUE 0.24
cancer of unknown primary KRAS_12-61 TP53 Inactivating mutation 36 29 TMB quintile 3 -0.09 -0.79 0.65 1444.17 1.00 88 28 21 8 TRUE 0.09
cancer of unknown primary KRAS_12-61 TP53 Inactivating mutation 36 29 TMB quintile 4 -0.59 -1.47 0.16 1364.13 1.00 80 32 25 4 TRUE 0.78
cancer of unknown primary KRAS_12-61 TP53 Inactivating mutation 42 57 TMB quintile 5 -0.24 -0.95 0.37 1385.74 1.00 102 31 46 11 TRUE 0.33
colorectal cancer KRAS_12-61 TP53 Inactivating mutation 27 39 TMB quintile 2 -0.68 -1.42 0.01 1558.82 1.00 76 22 34 5 TRUE 1.24
colorectal cancer KRAS_12-61 TP53 Inactivating mutation 175 146 TMB quintile 3 -0.71 -1.12 -0.32 1453.04 1.00 201 140 111 35 TRUE 3.35
colorectal cancer KRAS_12-61 TP53 Inactivating mutation 342 208 TMB quintile 4 -0.43 -0.74 -0.13 1497.60 1.00 319 268 134 74 TRUE 2.27
colorectal cancer KRAS_12-61 TP53 Inactivating mutation 315 108 TMB quintile 5 -0.57 -0.94 -0.20 1525.89 1.00 248 273 66 42 TRUE 2.46
colorectal cancer KRAS_12-61 TP53 Inactivating mutation 35 31 TMB quintile 6 -0.45 -1.12 0.24 1300.92 1.00 88 28 24 7 TRUE 0.73
non-small cell lung cancer KRAS_12-61 TP53 Inactivating mutation 83 49 TMB quintile 2 -0.80 -1.56 -0.09 1528.06 1.00 315 77 43 6 TRUE 1.55
non-small cell lung cancer KRAS_12-61 TP53 Inactivating mutation 155 116 TMB quintile 3 -0.94 -1.47 -0.46 1446.26 1.00 374 140 101 15 TRUE 3.50
non-small cell lung cancer KRAS_12-61 TP53 Inactivating mutation 263 145 TMB quintile 4 -1.06 -1.49 -0.67 1527.05 1.00 383 238 120 25 TRUE 6.16
non-small cell lung cancer KRAS_12-61 TP53 Inactivating mutation 454 346 TMB quintile 5 -0.91 -1.19 -0.64 1473.05 1.00 512 376 268 78 TRUE 9.75
pancreatic cancer KRAS_12-61 TP53 Inactivating mutation 277 72 TMB quintile 2 1.43 0.83 2.06 1222.42 1.00 65 209 4 68 TRUE 5.39
pancreatic cancer KRAS_12-61 TP53 Inactivating mutation 454 131 TMB quintile 3 1.50 0.95 2.08 1119.97 1.00 65 328 5 126 TRUE 6.47
pancreatic cancer KRAS_12-61 TP53 Inactivating mutation 239 74 TMB quintile 4 1.46 0.83 2.09 1257.02 1.00 37 170 5 69 TRUE 5.16
pancreatic cancer KRAS_12-61 TP53 Inactivating mutation 38 14 TMB quintile 5 1.44 0.72 2.15 1515.08 1.00 16 26 2 12 TRUE 4.24
uterine cancer KRAS_12-61 TP53 Inactivating mutation 13 21 TMB quintile 2 -0.74 -1.89 0.31 1460.27 1.00 113 11 19 2 TRUE 0.73
uterine cancer KRAS_12-61 TP53 Inactivating mutation 26 38 TMB quintile 3 -0.95 -2.02 0.04 1563.87 1.00 180 24 36 2 TRUE 1.14
uterine cancer KRAS_12-61 TP53 Inactivating mutation 44 33 TMB quintile 4 -1.09 -2.11 -0.19 1407.05 1.00 155 42 31 2 TRUE 1.52
uterine cancer KRAS_12-61 TP53 Inactivating mutation 63 19 TMB quintile 5 -0.87 -1.89 0.07 1421.50 1.00 185 60 16 3 TRUE 1.07
cancer of unknown primary KRAS_12-61 TP53 Inactivating mutation 146 144 TMB overall -0.27 -0.98 0.43 1509.43 1.00 352 117 115 29 TRUE 0.35
colorectal cancer KRAS_12-61 TP53 Inactivating mutation 894 532 TMB overall -0.56 -1.02 -0.03 1599.98 1.00 932 731 369 163 TRUE 1.66
non-small cell lung cancer KRAS_12-61 TP53 Inactivating mutation 955 656 TMB overall -0.93 -1.55 -0.35 1459.07 1.00 1584 831 532 124 TRUE 2.66
pancreatic cancer KRAS_12-61 TP53 Inactivating mutation 1008 291 TMB overall 1.45 0.87 2.06 1306.03 1.00 183 733 16 275 TRUE 5.78
uterine cancer KRAS_12-61 TP53 Inactivating mutation 146 111 TMB overall -0.91 -1.88 -0.05 1476.08 1.00 633 137 102 9 TRUE 1.31
colorectal cancer KRAS_12-61 FBXW7 Inactivating mutation 175 11 TMB quintile 3 -0.30 -1.31 0.63 1473.32 1.00 304 172 8 3 TRUE 0.26
colorectal cancer KRAS_12-61 FBXW7 Inactivating mutation 341 27 TMB quintile 4 -0.22 -0.90 0.48 1494.77 1.00 434 331 17 10 TRUE 0.28
colorectal cancer KRAS_12-61 FBXW7 Inactivating mutation 316 49 TMB quintile 5 0.36 -0.17 0.89 1671.67 1.00 293 287 20 29 TRUE 0.72
colorectal cancer KRAS_12-61 FBXW7 Inactivating mutation 34 24 TMB quintile 6 0.45 -0.45 1.29 1398.13 1.00 92 26 16 8 TRUE 0.51
colorectal cancer KRAS_12-61 FBXW7 Inactivating mutation 866 111 TMB overall 0.07 -0.83 1.01 1419.71 1.00 1123 816 61 50 TRUE 0.06
non-small cell lung cancer KRAS_12-61 SMARCA4 Inactivating mutation 155 12 TMB quintile 3 1.16 0.09 2.27 1508.31 1.00 467 147 4 8 FALSE 1.39
non-small cell lung cancer KRAS_12-61 SMARCA4 Inactivating mutation 262 28 TMB quintile 4 0.37 -0.36 1.04 1593.60 1.00 484 250 16 12 FALSE 0.53
non-small cell lung cancer KRAS_12-61 SMARCA4 Inactivating mutation 456 94 TMB quintile 5 -0.22 -0.67 0.22 1395.82 1.00 705 427 65 29 FALSE 0.45
non-small cell lung cancer KRAS_12-61 SMARCA4 Inactivating mutation 873 134 TMB overall 0.43 -0.76 1.73 1498.13 1.00 1656 824 85 49 FALSE 0.32
colorectal cancer KRAS_12-61 PTEN Inactivating mutation 341 17 TMB quintile 4 0.18 -0.78 1.09 1508.78 1.00 443 332 8 9 TRUE 0.15
colorectal cancer KRAS_12-61 PTEN Inactivating mutation 314 44 TMB quintile 5 -0.99 -1.67 -0.35 1472.54 1.00 290 302 32 12 TRUE 2.39
colorectal cancer KRAS_12-61 PTEN Inactivating mutation 38 57 TMB quintile 6 -0.14 -0.89 0.57 1233.55 1.00 77 25 44 13 TRUE 0.15
uterine cancer KRAS_12-61 PTEN Inactivating mutation 27 35 TMB quintile 3 -0.06 -1.07 0.86 1556.17 1.00 188 23 31 4 TRUE 0.04
uterine cancer KRAS_12-61 PTEN Inactivating mutation 47 72 TMB quintile 4 0.12 -0.59 0.76 1574.37 1.00 141 32 57 15 TRUE 0.15
uterine cancer KRAS_12-61 PTEN Inactivating mutation 78 190 TMB quintile 5 0.50 -0.01 1.01 1655.57 1.00 98 24 136 54 TRUE 1.23
uterine cancer KRAS_12-61 PTEN Inactivating mutation 7 41 TMB quintile 6 -0.36 -1.57 0.78 1508.83 1.00 26 4 38 3 TRUE 0.26
colorectal cancer KRAS_12-61 PTEN Inactivating mutation 693 118 TMB overall -0.31 -1.93 1.36 1490.12 1.00 810 659 84 34 TRUE 0.15
uterine cancer KRAS_12-61 PTEN Inactivating mutation 159 338 TMB overall 0.06 -0.97 1.03 1418.01 1.00 453 83 262 76 TRUE 0.04
colorectal cancer KRAS_12-61 ARID1A Inactivating mutation 342 24 TMB quintile 4 -0.36 -1.19 0.43 1588.48 1.00 435 333 15 9 TRUE 0.41
colorectal cancer KRAS_12-61 ARID1A Inactivating mutation 314 87 TMB quintile 5 -0.80 -1.25 -0.35 1225.42 1.00 267 286 59 28 TRUE 3.32
colorectal cancer KRAS_12-61 ARID1A Inactivating mutation 40 96 TMB quintile 6 -0.20 -0.91 0.46 1621.69 1.00 56 19 75 21 TRUE 0.24
non-small cell lung cancer KRAS_12-61 ARID1A Inactivating mutation 262 34 TMB quintile 4 -0.26 -0.92 0.32 1581.95 1.00 477 252 24 10 TRUE 0.40
non-small cell lung cancer KRAS_12-61 ARID1A Inactivating mutation 458 103 TMB quintile 5 -0.10 -0.50 0.30 1431.69 1.00 704 422 67 36 TRUE 0.21
pancreatic cancer KRAS_12-61 ARID1A Inactivating mutation 277 13 TMB quintile 2 -0.84 -1.67 0.02 1591.72 1.00 64 269 5 8 TRUE 1.29
pancreatic cancer KRAS_12-61 ARID1A Inactivating mutation 454 42 TMB quintile 3 -0.14 -0.82 0.65 1535.17 1.00 65 417 5 37 TRUE 0.14
pancreatic cancer KRAS_12-61 ARID1A Inactivating mutation 241 39 TMB quintile 4 -0.31 -1.03 0.43 1446.96 1.00 34 210 8 31 TRUE 0.40
pancreatic cancer KRAS_12-61 ARID1A Inactivating mutation 39 14 TMB quintile 5 -0.12 -1.05 0.80 1530.53 1.00 14 30 5 9 TRUE 0.09
uterine cancer KRAS_12-61 ARID1A Inactivating mutation 26 26 TMB quintile 3 0.44 -0.67 1.47 1523.90 1.00 194 22 22 4 TRUE 0.37
uterine cancer KRAS_12-61 ARID1A Inactivating mutation 47 69 TMB quintile 4 1.18 0.53 1.81 1494.13 1.00 145 23 45 24 TRUE 3.50
uterine cancer KRAS_12-61 ARID1A Inactivating mutation 86 284 TMB quintile 5 0.67 0.02 1.31 1544.23 1.00 61 12 210 74 TRUE 1.32
uterine cancer KRAS_12-61 ARID1A Inactivating mutation 12 75 TMB quintile 6 1.31 -0.28 3.41 1506.23 1.00 12 0 63 12 TRUE 0.78
colorectal cancer KRAS_12-61 ARID1A Inactivating mutation 696 207 TMB overall -0.42 -2.08 1.19 1555.51 1.00 758 638 149 58 TRUE 0.21
non-small cell lung cancer KRAS_12-61 ARID1A Inactivating mutation 720 137 TMB overall -0.18 -1.12 0.67 1215.52 1.00 1181 674 91 46 TRUE 0.15
pancreatic cancer KRAS_12-61 ARID1A Inactivating mutation 1011 108 TMB overall -0.36 -1.13 0.46 1493.96 1.00 177 926 23 85 TRUE 0.40
uterine cancer KRAS_12-61 ARID1A Inactivating mutation 171 454 TMB overall 0.91 -0.60 2.54 1532.50 1.00 412 57 340 114 TRUE 0.64
uterine cancer KRAS_12-61 PIK3R1 Inactivating mutation 26 13 TMB quintile 3 -1.02 -3.27 0.47 1487.57 1.00 202 26 13 0 TRUE 0.55
uterine cancer KRAS_12-61 PIK3R1 Inactivating mutation 45 32 TMB quintile 4 -0.54 -1.65 0.39 1449.22 1.00 160 41 28 4 TRUE 0.56
uterine cancer KRAS_12-61 PIK3R1 Inactivating mutation 69 57 TMB quintile 5 0.47 -0.17 1.12 1571.31 1.00 170 49 37 20 TRUE 0.84
uterine cancer KRAS_12-61 PIK3R1 Inactivating mutation 7 14 TMB quintile 6 -1.08 -3.31 0.47 1608.19 1.00 42 7 14 0 TRUE 0.55
uterine cancer KRAS_12-61 PIK3R1 Inactivating mutation 147 116 TMB overall -0.54 -1.99 0.50 1393.98 1.00 574 123 92 24 TRUE 0.40
pancreatic cancer KRAS_12-61 SMAD4 Inactivating mutation 277 18 TMB quintile 2 1.17 0.17 2.62 1342.57 1.00 69 259 0 18 TRUE 1.26
pancreatic cancer KRAS_12-61 SMAD4 Inactivating mutation 455 78 TMB quintile 3 0.94 0.20 1.72 1478.13 1.00 63 384 7 71 TRUE 1.75
pancreatic cancer KRAS_12-61 SMAD4 Inactivating mutation 239 44 TMB quintile 4 1.41 0.47 2.43 1482.22 1.00 40 197 2 42 TRUE 2.28
pancreatic cancer KRAS_12-61 SMAD4 Inactivating mutation 39 13 TMB quintile 5 1.66 0.56 3.02 1424.33 1.00 17 27 1 12 TRUE 2.14
pancreatic cancer KRAS_12-61 SMAD4 Inactivating mutation 1010 153 TMB overall 1.29 0.36 2.35 1526.86 1.00 189 867 10 143 TRUE 2.01
non-small cell lung cancer KRAS_12-61 RB1 Inactivating mutation 155 28 TMB quintile 3 -1.54 -2.55 -0.72 1467.56 1.00 444 154 27 1 TRUE 3.10
non-small cell lung cancer KRAS_12-61 RB1 Inactivating mutation 262 40 TMB quintile 4 -1.35 -2.11 -0.68 1478.06 1.00 465 257 35 5 TRUE 3.72
non-small cell lung cancer KRAS_12-61 RB1 Inactivating mutation 454 86 TMB quintile 5 -1.19 -1.73 -0.67 1547.98 1.00 700 439 71 15 TRUE 4.95
non-small cell lung cancer KRAS_12-61 RB1 Inactivating mutation 871 154 TMB overall -1.36 -2.10 -0.67 1534.15 1.00 1609 850 133 21 TRUE 3.63
uterine cancer KRAS_12-61 JAK1 Inactivating mutation 66 76 TMB quintile 5 0.28 -0.33 0.86 1155.12 1.00 160 46 56 20 TRUE 0.47
uterine cancer KRAS_12-61 JAK1 Inactivating mutation 9 25 TMB quintile 6 0.79 -0.28 2.11 1166.13 1.00 39 3 19 6 TRUE 0.71
uterine cancer KRAS_12-61 JAK1 Inactivating mutation 75 101 TMB overall 0.54 -0.88 2.08 1391.52 1.00 199 49 75 26 TRUE 0.35
uterine cancer KRAS_12-61 CTCF Inactivating mutation 64 83 TMB quintile 5 0.13 -0.46 0.69 1280.79 1.00 139 43 62 21 FALSE 0.18
uterine cancer KRAS_12-61 CTCF Inactivating mutation 7 26 TMB quintile 6 0.30 -0.82 1.57 1415.21 1.00 35 3 22 4 FALSE 0.22
uterine cancer KRAS_12-61 CTCF Inactivating mutation 71 109 TMB overall 0.23 -1.22 1.78 1525.95 1.00 174 46 84 25 FALSE 0.12
non-small cell lung cancer KRAS_12-61 NF1 Inactivating mutation 155 18 TMB quintile 3 -1.45 -2.80 -0.44 1437.08 1.00 454 154 17 1 TRUE 1.86
non-small cell lung cancer KRAS_12-61 NF1 Inactivating mutation 262 48 TMB quintile 4 -1.44 -2.25 -0.74 1433.44 1.00 465 257 43 5 TRUE 3.72
non-small cell lung cancer KRAS_12-61 NF1 Inactivating mutation 456 108 TMB quintile 5 -0.90 -1.40 -0.45 1311.51 1.00 694 433 85 23 TRUE 3.80
non-small cell lung cancer KRAS_12-61 NF1 Inactivating mutation 873 174 TMB overall -1.24 -2.16 -0.39 1324.30 1.00 1613 844 145 29 TRUE 2.14
colorectal cancer KRAS_12-61 APC Inactivating mutation 28 77 TMB quintile 2 -0.70 -1.43 -0.04 1354.91 1.00 50 18 67 10 TRUE 1.32
colorectal cancer KRAS_12-61 APC Inactivating mutation 207 422 TMB quintile 3 -0.42 -0.78 -0.07 1382.91 1.00 91 71 286 136 TRUE 1.76
colorectal cancer KRAS_12-61 APC Inactivating mutation 473 936 TMB quintile 4 -0.02 -0.34 0.28 1446.11 1.00 86 71 534 402 TRUE 0.05
colorectal cancer KRAS_12-61 APC Inactivating mutation 504 781 TMB quintile 5 0.83 0.49 1.15 1540.49 1.00 106 58 335 446 TRUE 5.95
colorectal cancer KRAS_12-61 APC Inactivating mutation 55 151 TMB quintile 6 0.16 -0.41 0.73 1364.67 1.00 54 14 110 41 TRUE 0.22
colorectal cancer KRAS_12-61 APC Inactivating mutation 1267 2367 TMB overall -0.04 -0.64 0.59 1412.51 1.00 387 232 1332 1035 TRUE 0.05
colorectal cancer KRAS_12-61 KMT2D Inactivating mutation 315 46 TMB quintile 5 -1.13 -1.79 -0.48 1540.06 1.00 288 303 34 12 FALSE 3.10
colorectal cancer KRAS_12-61 KMT2D Inactivating mutation 40 111 TMB quintile 6 -0.55 -1.26 0.14 1505.79 1.00 47 19 90 21 FALSE 0.92
uterine cancer KRAS_12-61 KMT2D Inactivating mutation 63 88 TMB quintile 5 -0.64 -1.29 -0.05 1357.60 1.00 134 49 74 14 FALSE 1.35
uterine cancer KRAS_12-61 KMT2D Inactivating mutation 8 29 TMB quintile 6 -0.58 -1.65 0.64 1363.94 1.00 34 5 26 3 FALSE 0.51
colorectal cancer KRAS_12-61 KMT2D Inactivating mutation 355 157 TMB overall -0.78 -3.15 1.85 1598.98 1.00 335 322 124 33 FALSE 0.27
uterine cancer KRAS_12-61 KMT2D Inactivating mutation 71 117 TMB overall -0.61 -1.89 0.74 1427.20 1.00 168 54 100 17 FALSE 0.41
non-small cell lung cancer KRAS_12-61 SETD2 Inactivating mutation 156 16 TMB quintile 3 -0.20 -1.30 0.56 1398.09 1.00 460 154 14 2 FALSE 0.18
non-small cell lung cancer KRAS_12-61 SETD2 Inactivating mutation 262 34 TMB quintile 4 0.05 -0.63 0.65 1370.92 1.00 481 251 23 11 FALSE 0.06
non-small cell lung cancer KRAS_12-61 SETD2 Inactivating mutation 459 50 TMB quintile 5 0.49 0.01 1.00 1505.23 1.00 749 432 23 27 FALSE 1.20
non-small cell lung cancer KRAS_12-61 SETD2 Inactivating mutation 877 100 TMB overall 0.10 -0.71 0.77 1309.87 1.00 1690 837 60 40 FALSE 0.11
non-small cell lung cancer KRAS_12-61 RBM10 Inactivating mutation 83 26 TMB quintile 2 0.55 -0.14 1.10 1424.55 1.00 338 77 20 6 FALSE 1.06
non-small cell lung cancer KRAS_12-61 RBM10 Inactivating mutation 155 40 TMB quintile 3 0.63 0.06 1.16 1229.93 1.00 445 141 26 14 FALSE 1.67
non-small cell lung cancer KRAS_12-61 RBM10 Inactivating mutation 263 76 TMB quintile 4 0.89 0.46 1.29 1454.21 1.00 465 222 35 41 FALSE 4.49
non-small cell lung cancer KRAS_12-61 RBM10 Inactivating mutation 457 133 TMB quintile 5 1.10 0.78 1.43 1270.06 1.00 721 374 50 83 FALSE 10.54
non-small cell lung cancer KRAS_12-61 RBM10 Inactivating mutation 958 275 TMB overall 0.80 0.28 1.23 1420.27 1.00 1969 814 131 144 FALSE 2.95
non-small cell lung cancer KRAS_12-61 CDKN2A Inactivating mutation 155 17 TMB quintile 3 0.08 -0.79 1.05 1538.72 1.00 460 149 11 6 TRUE 0.06
non-small cell lung cancer KRAS_12-61 CDKN2A Inactivating mutation 262 27 TMB quintile 4 -0.18 -0.90 0.55 1542.12 1.00 482 253 18 9 TRUE 0.20
non-small cell lung cancer KRAS_12-61 CDKN2A Inactivating mutation 455 96 TMB quintile 5 -0.82 -1.34 -0.34 1488.52 1.00 694 436 77 19 TRUE 2.83
pancreatic cancer KRAS_12-61 CDKN2A Inactivating mutation 277 25 TMB quintile 2 1.46 0.39 2.69 1520.98 1.00 68 253 1 24 TRUE 1.97
pancreatic cancer KRAS_12-61 CDKN2A Inactivating mutation 456 102 TMB quintile 3 2.10 1.16 3.30 1537.60 1.00 69 355 1 101 TRUE 4.02
pancreatic cancer KRAS_12-61 CDKN2A Inactivating mutation 243 63 TMB quintile 4 1.55 0.54 2.56 1517.21 1.00 37 185 5 58 TRUE 2.58
non-small cell lung cancer KRAS_12-61 CDKN2A Inactivating mutation 872 140 TMB overall -0.29 -1.28 0.79 1462.50 1.00 1636 838 106 34 TRUE 0.25
pancreatic cancer KRAS_12-61 CDKN2A Inactivating mutation 976 190 TMB overall 1.69 0.68 2.80 1338.69 1.00 174 793 7 183 TRUE 2.65
colorectal cancer KRAS_12-61 SOX9 Inactivating mutation 175 14 TMB quintile 3 -0.36 -1.29 0.54 1402.71 1.00 302 171 10 4 FALSE 0.36
colorectal cancer KRAS_12-61 SOX9 Inactivating mutation 342 73 TMB quintile 4 0.24 -0.22 0.71 1389.33 1.00 413 306 37 36 FALSE 0.51
colorectal cancer KRAS_12-61 SOX9 Inactivating mutation 317 88 TMB quintile 5 0.22 -0.20 0.63 1481.19 1.00 276 269 40 48 FALSE 0.49
colorectal cancer KRAS_12-61 SOX9 Inactivating mutation 35 43 TMB quintile 6 0.11 -0.60 0.84 1487.84 1.00 80 24 32 11 FALSE 0.11
colorectal cancer KRAS_12-61 SOX9 Inactivating mutation 869 218 TMB overall 0.06 -0.80 0.90 1308.39 1.00 1071 770 119 99 FALSE 0.05
non-small cell lung cancer KRAS_12-61 STK11 Inactivating mutation 157 59 TMB quintile 3 1.18 0.69 1.71 1454.88 1.00 443 126 28 31 TRUE 5.31
non-small cell lung cancer KRAS_12-61 STK11 Inactivating mutation 262 106 TMB quintile 4 1.23 0.84 1.62 1232.29 1.00 459 197 41 65 TRUE 8.81
non-small cell lung cancer KRAS_12-61 STK11 Inactivating mutation 455 183 TMB quintile 5 0.50 0.21 0.83 1376.62 1.00 670 372 100 83 TRUE 2.64
non-small cell lung cancer KRAS_12-61 STK11 Inactivating mutation 874 348 TMB overall 0.97 0.36 1.62 1343.63 1.00 1572 695 169 179 TRUE 2.52
non-small cell lung cancer KRAS_12-61 KEAP1 Inactivating mutation 262 35 TMB quintile 4 0.76 0.12 1.54 981.70 1.00 486 241 14 21 FALSE 1.47
non-small cell lung cancer KRAS_12-61 KEAP1 Inactivating mutation 454 69 TMB quintile 5 0.23 -0.32 0.80 74.80 1.04 726 428 43 26 FALSE 0.37
non-small cell lung cancer KRAS_12-61 KEAP1 Inactivating mutation 716 104 TMB overall 0.50 -0.44 1.60 1299.71 1.00 1212 669 57 47 FALSE 0.48
colorectal cancer KRAS_12-61 RNF43 Inactivating mutation 341 21 TMB quintile 4 -0.81 -1.76 0.07 1473.46 1.00 436 335 15 6 TRUE 1.05
colorectal cancer KRAS_12-61 RNF43 Inactivating mutation 317 58 TMB quintile 5 -1.24 -1.87 -0.66 1465.54 1.00 274 303 44 14 TRUE 4.32
colorectal cancer KRAS_12-61 RNF43 Inactivating mutation 39 113 TMB quintile 6 -0.63 -1.36 0.05 1408.00 1.00 42 18 92 21 TRUE 1.11
colorectal cancer KRAS_12-61 RNF43 Inactivating mutation 697 192 TMB overall -0.85 -2.71 0.97 1490.00 1.00 752 656 151 41 TRUE 0.44
colorectal cancer KRAS_12-61 B2M Inactivating mutation 300 45 TMB quintile 5 -0.73 -1.40 -0.14 1538.81 1.00 274 285 30 15 FALSE 1.60
colorectal cancer KRAS_12-61 B2M Inactivating mutation 42 66 TMB quintile 6 0.38 -0.35 1.09 1487.17 1.00 71 21 45 21 FALSE 0.52
colorectal cancer KRAS_12-61 B2M Inactivating mutation 342 111 TMB overall -0.16 -2.33 1.97 1569.20 1.00 345 306 75 36 FALSE 0.05
colorectal cancer KRAS_12-61 TCF7L2 Inactivating mutation 161 13 TMB quintile 3 -0.10 -1.12 0.84 1447.12 1.00 270 156 8 5 FALSE 0.08
colorectal cancer KRAS_12-61 TCF7L2 Inactivating mutation 310 39 TMB quintile 4 0.17 -0.44 0.79 1479.19 1.00 390 291 20 19 FALSE 0.23
colorectal cancer KRAS_12-61 TCF7L2 Inactivating mutation 290 57 TMB quintile 5 -0.38 -0.93 0.16 1349.64 1.00 256 267 34 23 FALSE 0.77
colorectal cancer KRAS_12-61 TCF7L2 Inactivating mutation 33 48 TMB quintile 6 0.35 -0.41 1.13 1441.96 1.00 69 19 34 14 FALSE 0.42
colorectal cancer KRAS_12-61 TCF7L2 Inactivating mutation 794 157 TMB overall 0.01 -0.98 1.07 1537.43 1.00 985 733 96 61 FALSE 0.01
non-small cell lung cancer KRAS_12-61 MGA Inactivating mutation 244 16 TMB quintile 4 0.19 -0.66 1.03 1662.80 1.00 425 237 9 7 FALSE 0.19
non-small cell lung cancer KRAS_12-61 MGA Inactivating mutation 417 73 TMB quintile 5 0.24 -0.24 0.68 1339.05 1.00 647 386 42 31 FALSE 0.51
non-small cell lung cancer KRAS_12-61 MGA Inactivating mutation 661 89 TMB overall 0.18 -1.19 1.60 1409.46 1.00 1072 623 51 38 FALSE 0.10
uterine cancer KRAS_12-61 ZFHX3 Inactivating mutation 40 12 TMB quintile 4 -0.24 -1.58 0.84 1487.25 1.00 155 38 10 2 FALSE 0.16
uterine cancer KRAS_12-61 ZFHX3 Inactivating mutation 60 66 TMB quintile 5 0.16 -0.44 0.75 1468.41 1.00 149 43 49 17 FALSE 0.21
uterine cancer KRAS_12-61 ZFHX3 Inactivating mutation 9 26 TMB quintile 6 0.12 -1.08 1.32 1577.74 1.00 35 5 22 4 FALSE 0.08
uterine cancer KRAS_12-61 ZFHX3 Inactivating mutation 109 104 TMB overall 0.01 -1.39 1.29 1563.24 1.00 339 86 81 23 FALSE 0.01
colorectal cancer KRAS_12-61 AMER1 Inactivating mutation 341 31 TMB quintile 4 0.88 0.26 1.64 1530.05 1.00 440 320 10 21 FALSE 1.90
colorectal cancer KRAS_12-61 AMER1 Inactivating mutation 313 47 TMB quintile 5 0.54 -0.04 1.15 1599.94 1.00 295 284 18 29 FALSE 1.19
colorectal cancer KRAS_12-61 AMER1 Inactivating mutation 34 27 TMB quintile 6 0.63 -0.29 1.45 1335.56 1.00 89 25 18 9 FALSE 0.82
colorectal cancer KRAS_12-61 AMER1 Inactivating mutation 688 105 TMB overall 0.69 -0.50 1.83 1568.31 1.00 824 629 46 59 FALSE 0.64
cancer of unknown primary RAS_12 TP53 Inactivating mutation 23 15 TMB quintile 2 -0.26 -1.15 0.58 1368.91 1.00 81 20 12 3 TRUE 0.25
cancer of unknown primary RAS_12 TP53 Inactivating mutation 34 29 TMB quintile 3 -0.15 -0.90 0.58 1182.94 1.00 89 27 22 7 TRUE 0.15
cancer of unknown primary RAS_12 TP53 Inactivating mutation 35 29 TMB quintile 4 -0.56 -1.44 0.26 1452.50 1.00 81 31 25 4 TRUE 0.70
cancer of unknown primary RAS_12 TP53 Inactivating mutation 36 57 TMB quintile 5 -0.09 -0.75 0.53 1552.02 1.00 108 25 46 11 TRUE 0.11
colorectal cancer RAS_12 TP53 Inactivating mutation 17 39 TMB quintile 2 -0.40 -1.21 0.37 1238.79 1.00 86 12 34 5 TRUE 0.49
colorectal cancer RAS_12 TP53 Inactivating mutation 147 146 TMB quintile 3 -0.69 -1.12 -0.28 1224.57 1.00 223 118 117 29 TRUE 2.82
colorectal cancer RAS_12 TP53 Inactivating mutation 283 208 TMB quintile 4 -0.44 -0.77 -0.10 1328.85 1.00 363 224 149 59 TRUE 2.06
colorectal cancer RAS_12 TP53 Inactivating mutation 235 108 TMB quintile 5 -0.53 -0.94 -0.12 1539.04 1.00 316 205 78 30 TRUE 1.91
colorectal cancer RAS_12 TP53 Inactivating mutation 22 31 TMB quintile 6 -0.49 -1.29 0.31 1617.11 1.00 98 18 27 4 TRUE 0.65
non-small cell lung cancer RAS_12 TP53 Inactivating mutation 75 49 TMB quintile 2 -0.90 -1.63 -0.16 1454.80 1.00 322 70 44 5 TRUE 1.75
non-small cell lung cancer RAS_12 TP53 Inactivating mutation 130 116 TMB quintile 3 -0.85 -1.41 -0.32 1518.25 1.00 398 116 102 14 TRUE 2.72
non-small cell lung cancer RAS_12 TP53 Inactivating mutation 231 145 TMB quintile 4 -1.22 -1.70 -0.75 1733.37 1.00 408 213 127 18 TRUE 6.49
non-small cell lung cancer RAS_12 TP53 Inactivating mutation 396 346 TMB quintile 5 -0.94 -1.22 -0.65 1471.33 1.00 557 331 281 65 TRUE 9.61
pancreatic cancer RAS_12 TP53 Inactivating mutation 252 72 TMB quintile 2 0.68 0.24 1.19 1492.03 1.00 84 190 10 62 TRUE 2.34
pancreatic cancer RAS_12 TP53 Inactivating mutation 420 131 TMB quintile 3 0.74 0.35 1.19 1436.55 1.00 90 303 14 117 TRUE 3.17
pancreatic cancer RAS_12 TP53 Inactivating mutation 216 74 TMB quintile 4 0.51 -0.03 0.98 1536.86 1.00 48 159 17 57 TRUE 1.32
pancreatic cancer RAS_12 TP53 Inactivating mutation 34 14 TMB quintile 5 0.60 -0.04 1.20 1656.46 1.00 18 24 4 10 TRUE 1.35
uterine cancer RAS_12 TP53 Inactivating mutation 13 21 TMB quintile 2 -1.06 -2.24 0.02 1359.55 1.00 112 12 20 1 TRUE 1.20
uterine cancer RAS_12 TP53 Inactivating mutation 24 38 TMB quintile 3 -1.05 -2.14 -0.09 1500.51 1.00 182 22 36 2 TRUE 1.37
uterine cancer RAS_12 TP53 Inactivating mutation 40 33 TMB quintile 4 -1.12 -2.16 -0.21 1540.94 1.00 159 38 31 2 TRUE 1.64
uterine cancer RAS_12 TP53 Inactivating mutation 52 19 TMB quintile 5 -1.03 -2.17 -0.06 1413.33 1.00 195 50 17 2 TRUE 1.32
cancer of unknown primary RAS_12 TP53 Inactivating mutation 132 144 TMB overall -0.27 -0.99 0.41 1275.45 1.00 364 105 117 27 TRUE 0.35
colorectal cancer RAS_12 TP53 Inactivating mutation 704 532 TMB overall -0.51 -1.02 0.01 1486.67 1.00 1086 577 405 127 TRUE 1.21
non-small cell lung cancer RAS_12 TP53 Inactivating mutation 832 656 TMB overall -0.97 -1.55 -0.35 1407.72 1.00 1685 730 554 102 TRUE 2.76
pancreatic cancer RAS_12 TP53 Inactivating mutation 922 291 TMB overall 0.64 0.20 1.10 1429.33 1.00 240 676 45 246 TRUE 2.20
uterine cancer RAS_12 TP53 Inactivating mutation 129 111 TMB overall -1.06 -2.06 -0.21 1483.14 1.00 648 122 104 7 TRUE 1.61
colorectal cancer RAS_12 FBXW7 Inactivating mutation 147 11 TMB quintile 3 -0.30 -1.44 0.71 1429.58 1.00 332 144 8 3 TRUE 0.24
colorectal cancer RAS_12 FBXW7 Inactivating mutation 282 27 TMB quintile 4 -0.58 -1.41 0.20 1414.95 1.00 489 276 21 6 TRUE 0.80
colorectal cancer RAS_12 FBXW7 Inactivating mutation 236 49 TMB quintile 5 0.34 -0.22 0.89 1623.86 1.00 367 213 26 23 TRUE 0.65
colorectal cancer RAS_12 FBXW7 Inactivating mutation 20 24 TMB quintile 6 -0.21 -1.40 0.85 1654.23 1.00 101 17 21 3 TRUE 0.15
colorectal cancer RAS_12 FBXW7 Inactivating mutation 685 111 TMB overall -0.19 -1.10 0.77 1425.59 1.00 1289 650 76 35 TRUE 0.16
non-small cell lung cancer RAS_12 SMARCA4 Inactivating mutation 130 12 TMB quintile 3 1.42 0.36 2.54 1449.35 1.00 492 122 4 8 FALSE 1.89
non-small cell lung cancer RAS_12 SMARCA4 Inactivating mutation 231 28 TMB quintile 4 0.54 -0.20 1.28 1485.46 1.00 515 219 16 12 FALSE 0.83
non-small cell lung cancer RAS_12 SMARCA4 Inactivating mutation 398 94 TMB quintile 5 -0.16 -0.65 0.30 1391.51 1.00 760 372 68 26 FALSE 0.30
non-small cell lung cancer RAS_12 SMARCA4 Inactivating mutation 759 134 TMB overall 0.59 -0.64 1.88 1498.14 1.00 1767 713 88 46 FALSE 0.46
colorectal cancer RAS_12 PTEN Inactivating mutation 282 17 TMB quintile 4 0.25 -0.66 1.16 1557.57 1.00 501 274 9 8 TRUE 0.24
colorectal cancer RAS_12 PTEN Inactivating mutation 233 44 TMB quintile 5 -1.15 -1.95 -0.39 1455.08 1.00 366 226 37 7 TRUE 2.28
colorectal cancer RAS_12 PTEN Inactivating mutation 24 57 TMB quintile 6 -0.20 -1.13 0.62 1591.88 1.00 86 16 49 8 TRUE 0.18
uterine cancer RAS_12 PTEN Inactivating mutation 25 35 TMB quintile 3 0.09 -0.90 0.98 1340.33 1.00 190 21 31 4 TRUE 0.07
uterine cancer RAS_12 PTEN Inactivating mutation 42 72 TMB quintile 4 0.23 -0.50 0.90 1473.10 1.00 145 28 58 14 TRUE 0.28
uterine cancer RAS_12 PTEN Inactivating mutation 65 190 TMB quintile 5 0.41 -0.13 0.96 1464.51 1.00 101 21 146 44 TRUE 0.83
colorectal cancer RAS_12 PTEN Inactivating mutation 539 118 TMB overall -0.41 -2.25 1.30 1391.06 1.01 953 516 95 23 TRUE 0.20
uterine cancer RAS_12 PTEN Inactivating mutation 134 338 TMB overall 0.25 -0.82 1.32 1286.22 1.00 466 70 274 64 TRUE 0.18
colorectal cancer RAS_12 ARID1A Inactivating mutation 283 24 TMB quintile 4 -0.06 -0.92 0.74 1646.33 1.00 494 274 15 9 TRUE 0.05
colorectal cancer RAS_12 ARID1A Inactivating mutation 234 87 TMB quintile 5 -0.74 -1.27 -0.24 1444.13 1.00 339 214 67 20 TRUE 2.40
colorectal cancer RAS_12 ARID1A Inactivating mutation 25 96 TMB quintile 6 -0.40 -1.23 0.40 1308.47 1.00 62 13 84 12 TRUE 0.46
non-small cell lung cancer RAS_12 ARID1A Inactivating mutation 231 34 TMB quintile 4 -0.45 -1.19 0.18 1529.85 1.00 505 224 27 7 TRUE 0.68
non-small cell lung cancer RAS_12 ARID1A Inactivating mutation 400 103 TMB quintile 5 -0.11 -0.53 0.26 1454.66 1.00 758 368 71 32 TRUE 0.22
pancreatic cancer RAS_12 ARID1A Inactivating mutation 252 13 TMB quintile 2 -0.88 -1.79 -0.08 1438.50 1.00 87 246 7 6 TRUE 1.31
pancreatic cancer RAS_12 ARID1A Inactivating mutation 420 42 TMB quintile 3 0.10 -0.56 0.88 1371.83 1.00 98 384 6 36 TRUE 0.11
pancreatic cancer RAS_12 ARID1A Inactivating mutation 217 39 TMB quintile 4 -0.20 -0.84 0.48 1399.20 1.00 55 189 11 28 TRUE 0.27
pancreatic cancer RAS_12 ARID1A Inactivating mutation 35 14 TMB quintile 5 -0.07 -0.99 0.83 1383.06 1.00 17 27 6 8 TRUE 0.06
uterine cancer RAS_12 ARID1A Inactivating mutation 24 26 TMB quintile 3 0.51 -0.67 1.54 1467.40 1.00 196 20 22 4 TRUE 0.44
uterine cancer RAS_12 ARID1A Inactivating mutation 43 69 TMB quintile 4 1.28 0.62 2.00 1501.17 1.00 148 20 46 23 TRUE 3.57
uterine cancer RAS_12 ARID1A Inactivating mutation 73 284 TMB quintile 5 0.67 -0.05 1.45 1530.48 1.00 63 10 221 63 TRUE 1.16
colorectal cancer RAS_12 ARID1A Inactivating mutation 542 207 TMB overall -0.42 -2.00 1.37 1357.88 1.00 895 501 166 41 TRUE 0.21
non-small cell lung cancer RAS_12 ARID1A Inactivating mutation 631 137 TMB overall -0.28 -1.41 0.72 1493.09 1.00 1263 592 98 39 TRUE 0.21
pancreatic cancer RAS_12 ARID1A Inactivating mutation 924 108 TMB overall -0.26 -1.08 0.52 1430.14 1.00 257 846 30 78 TRUE 0.28
uterine cancer RAS_12 ARID1A Inactivating mutation 143 454 TMB overall 0.74 -0.85 2.47 1497.39 1.00 419 50 361 93 TRUE 0.44
uterine cancer RAS_12 PIK3R1 Inactivating mutation 24 13 TMB quintile 3 -1.07 -3.13 0.38 1534.87 1.00 204 24 13 0 TRUE 0.62
uterine cancer RAS_12 PIK3R1 Inactivating mutation 41 32 TMB quintile 4 -0.52 -1.65 0.41 1277.70 1.00 164 37 28 4 TRUE 0.52
uterine cancer RAS_12 PIK3R1 Inactivating mutation 56 57 TMB quintile 5 0.07 -0.65 0.76 1610.69 1.00 176 43 44 13 TRUE 0.07
uterine cancer RAS_12 PIK3R1 Inactivating mutation 123 116 TMB overall -0.62 -2.05 0.56 1580.34 1.00 591 106 99 17 TRUE 0.47
pancreatic cancer RAS_12 SMAD4 Inactivating mutation 252 18 TMB quintile 2 0.66 -0.15 1.83 1559.53 1.00 93 235 1 17 TRUE 0.77
pancreatic cancer RAS_12 SMAD4 Inactivating mutation 421 78 TMB quintile 3 0.47 -0.12 1.07 1373.52 1.00 91 356 13 65 TRUE 0.93
pancreatic cancer RAS_12 SMAD4 Inactivating mutation 216 44 TMB quintile 4 0.58 -0.10 1.30 1405.37 1.00 57 180 8 36 TRUE 1.00
pancreatic cancer RAS_12 SMAD4 Inactivating mutation 35 13 TMB quintile 5 1.07 0.16 2.10 1574.71 1.00 20 24 2 11 TRUE 1.47
pancreatic cancer RAS_12 SMAD4 Inactivating mutation 924 153 TMB overall 0.69 -0.03 1.56 1521.86 1.00 261 795 24 129 TRUE 1.11
non-small cell lung cancer RAS_12 RB1 Inactivating mutation 130 28 TMB quintile 3 -1.48 -2.58 -0.59 1444.36 1.00 469 129 27 1 TRUE 2.54
non-small cell lung cancer RAS_12 RB1 Inactivating mutation 231 40 TMB quintile 4 -1.37 -2.23 -0.65 1455.46 1.00 495 227 36 4 TRUE 3.26
non-small cell lung cancer RAS_12 RB1 Inactivating mutation 396 86 TMB quintile 5 -1.15 -1.73 -0.61 1536.15 1.00 756 383 73 13 TRUE 4.15
non-small cell lung cancer RAS_12 RB1 Inactivating mutation 757 154 TMB overall -1.33 -2.12 -0.64 1452.70 1.00 1720 739 136 18 TRUE 3.31
uterine cancer RAS_12 JAK1 Inactivating mutation 55 76 TMB quintile 5 -0.09 -0.74 0.56 1494.21 1.00 165 41 62 14 TRUE 0.11
uterine cancer RAS_12 JAK1 Inactivating mutation 57 101 TMB overall -0.09 -2.23 2.13 1610.18 1.00 206 42 86 15 TRUE 0.03
uterine cancer RAS_12 CTCF Inactivating mutation 54 83 TMB quintile 5 -0.16 -0.80 0.44 1390.84 1.00 144 38 67 16 FALSE 0.21
uterine cancer RAS_12 CTCF Inactivating mutation 56 109 TMB overall -0.91 -3.94 1.43 1521.03 1.00 180 40 93 16 FALSE 0.29
non-small cell lung cancer RAS_12 NF1 Inactivating mutation 130 18 TMB quintile 3 -2.21 -4.28 -0.78 1580.63 1.00 478 130 18 0 TRUE 1.80
non-small cell lung cancer RAS_12 NF1 Inactivating mutation 231 48 TMB quintile 4 -2.11 -3.40 -1.18 1478.12 1.00 493 229 46 2 TRUE 3.52
non-small cell lung cancer RAS_12 NF1 Inactivating mutation 397 108 TMB quintile 5 -1.12 -1.68 -0.60 1464.46 1.01 747 380 91 17 TRUE 4.20
non-small cell lung cancer RAS_12 NF1 Inactivating mutation 758 174 TMB overall -1.79 -3.17 -0.73 1423.53 1.00 1718 739 155 19 TRUE 2.43
colorectal cancer RAS_12 APC Inactivating mutation 18 77 TMB quintile 2 -0.85 -1.72 -0.05 1491.46 1.00 55 13 72 5 TRUE 1.32
colorectal cancer RAS_12 APC Inactivating mutation 176 422 TMB quintile 3 -0.17 -0.52 0.19 1583.78 1.00 108 54 300 122 TRUE 0.45
colorectal cancer RAS_12 APC Inactivating mutation 387 936 TMB quintile 4 -0.07 -0.39 0.26 1529.47 1.00 97 60 609 327 TRUE 0.17
colorectal cancer RAS_12 APC Inactivating mutation 370 781 TMB quintile 5 0.48 0.15 0.80 1543.45 1.00 115 49 460 321 TRUE 2.30
colorectal cancer RAS_12 APC Inactivating mutation 36 151 TMB quintile 6 0.31 -0.36 1.04 1488.15 1.00 61 7 122 29 TRUE 0.41
colorectal cancer RAS_12 APC Inactivating mutation 987 2367 TMB overall -0.06 -0.71 0.60 1627.05 1.00 436 183 1563 804 TRUE 0.07
colorectal cancer RAS_12 KMT2D Inactivating mutation 235 46 TMB quintile 5 -0.98 -1.78 -0.25 1548.31 1.00 365 226 37 9 FALSE 1.96
colorectal cancer RAS_12 KMT2D Inactivating mutation 26 111 TMB quintile 6 -0.29 -1.11 0.56 1349.45 1.00 55 11 96 15 FALSE 0.30
uterine cancer RAS_12 KMT2D Inactivating mutation 52 88 TMB quintile 5 -1.24 -2.09 -0.46 1459.09 1.00 139 44 80 8 FALSE 2.58
colorectal cancer RAS_12 KMT2D Inactivating mutation 261 157 TMB overall -0.58 -3.08 2.06 1187.30 1.00 420 237 133 24 FALSE 0.19
uterine cancer RAS_12 KMT2D Inactivating mutation 54 117 TMB overall -1.70 -4.87 0.74 1485.31 1.00 176 46 109 8 FALSE 0.69
non-small cell lung cancer RAS_12 SETD2 Inactivating mutation 131 16 TMB quintile 3 -0.22 -1.24 0.54 1409.80 1.00 485 129 14 2 FALSE 0.20
non-small cell lung cancer RAS_12 SETD2 Inactivating mutation 231 34 TMB quintile 4 -0.16 -0.94 0.48 1297.99 1.00 509 223 26 8 FALSE 0.17
non-small cell lung cancer RAS_12 SETD2 Inactivating mutation 400 50 TMB quintile 5 0.33 -0.19 0.84 1283.67 1.00 803 378 28 22 FALSE 0.66
non-small cell lung cancer RAS_12 SETD2 Inactivating mutation 762 100 TMB overall -0.01 -0.79 0.64 1460.09 1.00 1797 730 68 32 FALSE 0.01
non-small cell lung cancer RAS_12 RBM10 Inactivating mutation 75 26 TMB quintile 2 0.47 -0.25 1.07 1500.93 1.00 345 70 21 5 FALSE 0.81
non-small cell lung cancer RAS_12 RBM10 Inactivating mutation 130 40 TMB quintile 3 0.58 0.04 1.08 1521.61 1.00 468 118 28 12 FALSE 1.52
non-small cell lung cancer RAS_12 RBM10 Inactivating mutation 232 76 TMB quintile 4 0.79 0.39 1.19 1561.86 1.00 491 196 40 36 FALSE 3.89
non-small cell lung cancer RAS_12 RBM10 Inactivating mutation 399 133 TMB quintile 5 0.91 0.58 1.23 1378.90 1.00 766 329 63 70 FALSE 7.64
non-small cell lung cancer RAS_12 RBM10 Inactivating mutation 836 275 TMB overall 0.70 0.21 1.15 1575.02 1.00 2070 713 152 123 FALSE 2.50
non-small cell lung cancer RAS_12 CDKN2A Inactivating mutation 130 17 TMB quintile 3 0.27 -0.64 1.27 1543.35 1.00 485 124 11 6 TRUE 0.23
non-small cell lung cancer RAS_12 CDKN2A Inactivating mutation 231 27 TMB quintile 4 -0.15 -0.91 0.61 1415.80 1.00 512 223 19 8 TRUE 0.16
non-small cell lung cancer RAS_12 CDKN2A Inactivating mutation 397 96 TMB quintile 5 -0.74 -1.26 -0.22 1446.02 1.00 750 380 79 17 TRUE 2.20
pancreatic cancer RAS_12 CDKN2A Inactivating mutation 252 25 TMB quintile 2 0.79 0.11 1.58 1484.45 1.00 91 230 3 22 TRUE 1.36
pancreatic cancer RAS_12 CDKN2A Inactivating mutation 422 102 TMB quintile 3 1.26 0.65 1.94 1479.13 1.00 97 327 7 95 TRUE 3.97
pancreatic cancer RAS_12 CDKN2A Inactivating mutation 220 63 TMB quintile 4 0.91 0.21 1.60 1396.86 1.00 55 167 10 53 TRUE 1.98
non-small cell lung cancer RAS_12 CDKN2A Inactivating mutation 758 140 TMB overall -0.20 -1.19 0.88 1498.27 1.00 1747 727 109 31 TRUE 0.16
pancreatic cancer RAS_12 CDKN2A Inactivating mutation 894 190 TMB overall 0.99 0.20 1.81 1318.83 1.00 243 724 20 170 TRUE 1.80
colorectal cancer RAS_12 SOX9 Inactivating mutation 147 14 TMB quintile 3 -0.42 -1.48 0.54 1471.00 1.00 329 144 11 3 FALSE 0.37
colorectal cancer RAS_12 SOX9 Inactivating mutation 283 73 TMB quintile 4 0.24 -0.25 0.69 1373.79 1.00 466 253 43 30 FALSE 0.47
colorectal cancer RAS_12 SOX9 Inactivating mutation 237 88 TMB quintile 5 0.22 -0.23 0.65 1213.85 1.00 345 200 51 37 FALSE 0.48
colorectal cancer RAS_12 SOX9 Inactivating mutation 20 43 TMB quintile 6 0.38 -0.54 1.22 1474.09 1.00 92 12 35 8 FALSE 0.40
colorectal cancer RAS_12 SOX9 Inactivating mutation 687 218 TMB overall 0.12 -0.86 1.10 1415.48 1.00 1232 609 140 78 FALSE 0.09
non-small cell lung cancer RAS_12 STK11 Inactivating mutation 132 59 TMB quintile 3 0.96 0.46 1.46 1574.91 1.00 461 108 35 24 TRUE 3.71
non-small cell lung cancer RAS_12 STK11 Inactivating mutation 231 106 TMB quintile 4 1.20 0.80 1.61 1262.54 1.00 485 171 46 60 TRUE 8.18
non-small cell lung cancer RAS_12 STK11 Inactivating mutation 397 183 TMB quintile 5 0.41 0.09 0.74 1476.92 1.00 715 327 113 70 TRUE 1.85
non-small cell lung cancer RAS_12 STK11 Inactivating mutation 760 348 TMB overall 0.85 0.19 1.52 1420.29 1.00 1661 606 194 154 TRUE 2.03
non-small cell lung cancer RAS_12 KEAP1 Inactivating mutation 231 35 TMB quintile 4 0.69 -0.04 1.50 669.17 1.01 515 212 16 19 FALSE 1.17
non-small cell lung cancer RAS_12 KEAP1 Inactivating mutation 396 69 TMB quintile 5 0.14 -0.40 0.62 573.17 1.01 780 374 47 22 FALSE 0.23
non-small cell lung cancer RAS_12 KEAP1 Inactivating mutation 627 104 TMB overall 0.42 -0.66 1.50 1548.60 1.00 1295 586 63 41 FALSE 0.34
colorectal cancer RAS_12 RNF43 Inactivating mutation 282 21 TMB quintile 4 -0.68 -1.68 0.22 1591.89 1.00 494 277 16 5 TRUE 0.78
colorectal cancer RAS_12 RNF43 Inactivating mutation 237 58 TMB quintile 5 -0.93 -1.63 -0.30 1355.23 1.00 352 225 46 12 TRUE 2.33
colorectal cancer RAS_12 RNF43 Inactivating mutation 24 113 TMB quintile 6 -0.40 -1.25 0.43 1042.34 1.00 50 10 99 14 TRUE 0.45
colorectal cancer RAS_12 RNF43 Inactivating mutation 543 192 TMB overall -0.69 -2.52 1.25 1547.03 1.00 896 512 161 31 TRUE 0.33
colorectal cancer RAS_12 B2M Inactivating mutation 221 45 TMB quintile 5 -0.52 -1.23 0.12 1444.08 1.00 350 209 33 12 FALSE 0.86
colorectal cancer RAS_12 B2M Inactivating mutation 25 66 TMB quintile 6 0.04 -0.78 0.82 1398.91 1.00 78 14 55 11 FALSE 0.03
colorectal cancer RAS_12 B2M Inactivating mutation 246 111 TMB overall -0.23 -2.38 1.94 1422.79 1.00 428 223 88 23 FALSE 0.08
colorectal cancer RAS_12 TCF7L2 Inactivating mutation 133 13 TMB quintile 3 0.14 -0.90 1.10 1485.17 1.00 298 128 8 5 FALSE 0.10
colorectal cancer RAS_12 TCF7L2 Inactivating mutation 259 39 TMB quintile 4 0.38 -0.25 1.01 1620.36 1.00 440 241 21 18 FALSE 0.62
colorectal cancer RAS_12 TCF7L2 Inactivating mutation 218 57 TMB quintile 5 -0.61 -1.22 -0.03 1670.38 1.00 319 204 43 14 FALSE 1.31
colorectal cancer RAS_12 TCF7L2 Inactivating mutation 19 48 TMB quintile 6 0.43 -0.48 1.31 1581.69 1.00 78 10 39 9 FALSE 0.45
colorectal cancer RAS_12 TCF7L2 Inactivating mutation 629 157 TMB overall 0.07 -1.06 1.19 1430.11 1.00 1135 583 111 46 FALSE 0.04
non-small cell lung cancer RAS_12 MGA Inactivating mutation 217 16 TMB quintile 4 0.50 -0.31 1.46 1473.40 1.00 453 209 8 8 FALSE 0.61
non-small cell lung cancer RAS_12 MGA Inactivating mutation 365 73 TMB quintile 5 0.30 -0.17 0.78 1517.81 1.00 696 337 45 28 FALSE 0.68
non-small cell lung cancer RAS_12 MGA Inactivating mutation 582 89 TMB overall 0.42 -1.07 1.87 1406.65 1.00 1149 546 53 36 FALSE 0.27
uterine cancer RAS_12 ZFHX3 Inactivating mutation 37 12 TMB quintile 4 -0.29 -1.82 0.97 1505.23 1.00 158 35 10 2 FALSE 0.16
uterine cancer RAS_12 ZFHX3 Inactivating mutation 49 66 TMB quintile 5 0.05 -0.64 0.71 1356.68 1.00 156 36 53 13 FALSE 0.05
uterine cancer RAS_12 ZFHX3 Inactivating mutation 88 104 TMB overall -0.16 -1.91 1.49 1456.37 1.00 353 72 88 16 FALSE 0.07
colorectal cancer RAS_12 AMER1 Inactivating mutation 282 31 TMB quintile 4 1.07 0.35 1.75 1696.64 1.00 498 262 11 20 FALSE 2.45
colorectal cancer RAS_12 AMER1 Inactivating mutation 233 47 TMB quintile 5 0.45 -0.15 1.02 1394.85 1.00 368 211 25 22 FALSE 0.87
colorectal cancer RAS_12 AMER1 Inactivating mutation 20 27 TMB quintile 6 0.18 -0.88 1.13 1390.03 1.00 98 16 23 4 FALSE 0.13
colorectal cancer RAS_12 AMER1 Inactivating mutation 535 105 TMB overall 0.57 -0.75 1.86 1451.45 1.00 964 489 59 46 FALSE 0.40
cancer of unknown primary KRAS_12 TP53 Inactivating mutation 23 15 TMB quintile 2 -0.20 -1.14 0.61 1436.32 1.00 81 20 12 3 TRUE 0.18
cancer of unknown primary KRAS_12 TP53 Inactivating mutation 32 29 TMB quintile 3 -0.04 -0.79 0.74 1686.51 1.00 91 25 22 7 TRUE 0.04
cancer of unknown primary KRAS_12 TP53 Inactivating mutation 33 29 TMB quintile 4 -0.48 -1.33 0.28 1595.19 1.00 83 29 25 4 TRUE 0.58
cancer of unknown primary KRAS_12 TP53 Inactivating mutation 35 57 TMB quintile 5 -0.06 -0.72 0.59 1448.81 1.00 109 24 46 11 TRUE 0.07
colorectal cancer KRAS_12 TP53 Inactivating mutation 17 39 TMB quintile 2 -0.45 -1.24 0.33 1358.78 1.00 86 12 34 5 TRUE 0.58
colorectal cancer KRAS_12 TP53 Inactivating mutation 144 146 TMB quintile 3 -0.66 -1.11 -0.26 1056.92 1.00 226 115 117 29 TRUE 2.66
colorectal cancer KRAS_12 TP53 Inactivating mutation 272 208 TMB quintile 4 -0.46 -0.83 -0.12 1415.75 1.00 371 216 152 56 TRUE 2.17
colorectal cancer KRAS_12 TP53 Inactivating mutation 229 108 TMB quintile 5 -0.60 -1.03 -0.19 1563.58 1.00 320 201 80 28 TRUE 2.23
colorectal cancer KRAS_12 TP53 Inactivating mutation 19 31 TMB quintile 6 -0.76 -1.62 0.04 1470.96 1.00 99 17 29 2 TRUE 1.11
non-small cell lung cancer KRAS_12 TP53 Inactivating mutation 75 49 TMB quintile 2 -0.89 -1.61 -0.13 1358.58 1.00 322 70 44 5 TRUE 1.70
non-small cell lung cancer KRAS_12 TP53 Inactivating mutation 130 116 TMB quintile 3 -0.86 -1.43 -0.34 1541.63 1.00 398 116 102 14 TRUE 2.73
non-small cell lung cancer KRAS_12 TP53 Inactivating mutation 230 145 TMB quintile 4 -1.27 -1.78 -0.81 1346.31 1.00 408 213 128 17 TRUE 6.76
non-small cell lung cancer KRAS_12 TP53 Inactivating mutation 395 346 TMB quintile 5 -0.92 -1.21 -0.64 1219.23 1.00 558 330 281 65 TRUE 8.89
pancreatic cancer KRAS_12 TP53 Inactivating mutation 252 72 TMB quintile 2 0.69 0.25 1.18 1344.20 1.00 84 190 10 62 TRUE 2.39
pancreatic cancer KRAS_12 TP53 Inactivating mutation 419 131 TMB quintile 3 0.76 0.35 1.19 1395.65 1.00 91 302 14 117 TRUE 3.28
pancreatic cancer KRAS_12 TP53 Inactivating mutation 216 74 TMB quintile 4 0.52 -0.02 0.99 1367.16 1.00 48 159 17 57 TRUE 1.33
pancreatic cancer KRAS_12 TP53 Inactivating mutation 34 14 TMB quintile 5 0.62 0.00 1.18 1513.08 1.00 18 24 4 10 TRUE 1.42
uterine cancer KRAS_12 TP53 Inactivating mutation 12 21 TMB quintile 2 -1.37 -2.69 -0.26 1182.48 1.00 113 11 20 1 TRUE 1.58
uterine cancer KRAS_12 TP53 Inactivating mutation 24 38 TMB quintile 3 -1.33 -2.52 -0.27 1400.23 1.00 182 22 36 2 TRUE 1.68
uterine cancer KRAS_12 TP53 Inactivating mutation 39 33 TMB quintile 4 -1.45 -2.61 -0.45 1319.38 1.00 160 37 31 2 TRUE 1.97
uterine cancer KRAS_12 TP53 Inactivating mutation 49 19 TMB quintile 5 -1.64 -3.00 -0.53 1144.08 1.00 196 49 19 0 TRUE 2.00
cancer of unknown primary KRAS_12 TP53 Inactivating mutation 126 144 TMB overall -0.18 -0.89 0.50 1615.30 1.00 370 99 117 27 TRUE 0.22
colorectal cancer KRAS_12 TP53 Inactivating mutation 681 532 TMB overall -0.60 -1.17 -0.07 1560.96 1.00 1102 561 412 120 TRUE 1.56
non-small cell lung cancer KRAS_12 TP53 Inactivating mutation 830 656 TMB overall -0.98 -1.56 -0.38 1390.65 1.00 1686 729 555 101 TRUE 2.94
pancreatic cancer KRAS_12 TP53 Inactivating mutation 921 291 TMB overall 0.65 0.19 1.14 1290.54 1.00 241 675 45 246 TRUE 2.11
uterine cancer KRAS_12 TP53 Inactivating mutation 124 111 TMB overall -1.45 -2.53 -0.44 1301.88 1.00 651 119 106 5 TRUE 2.24
colorectal cancer KRAS_12 FBXW7 Inactivating mutation 144 11 TMB quintile 3 -0.28 -1.39 0.73 1503.26 1.00 335 141 8 3 TRUE 0.22
colorectal cancer KRAS_12 FBXW7 Inactivating mutation 271 27 TMB quintile 4 -0.53 -1.38 0.26 1301.45 1.00 500 265 21 6 TRUE 0.73
colorectal cancer KRAS_12 FBXW7 Inactivating mutation 230 49 TMB quintile 5 0.31 -0.28 0.86 1414.78 1.00 372 208 27 22 TRUE 0.55
colorectal cancer KRAS_12 FBXW7 Inactivating mutation 18 24 TMB quintile 6 -0.12 -1.26 0.89 1468.79 1.00 103 15 21 3 TRUE 0.08
colorectal cancer KRAS_12 FBXW7 Inactivating mutation 663 111 TMB overall -0.16 -1.11 0.72 1538.11 1.00 1310 629 77 34 TRUE 0.14
non-small cell lung cancer KRAS_12 SMARCA4 Inactivating mutation 130 12 TMB quintile 3 1.43 0.35 2.64 1267.83 1.00 492 122 4 8 FALSE 1.90
non-small cell lung cancer KRAS_12 SMARCA4 Inactivating mutation 230 28 TMB quintile 4 0.55 -0.16 1.24 1242.84 1.00 516 218 16 12 FALSE 0.91
non-small cell lung cancer KRAS_12 SMARCA4 Inactivating mutation 397 94 TMB quintile 5 -0.22 -0.69 0.26 1395.46 1.00 760 372 69 25 FALSE 0.43
non-small cell lung cancer KRAS_12 SMARCA4 Inactivating mutation 757 134 TMB overall 0.57 -0.63 1.93 1528.34 1.00 1768 712 89 45 FALSE 0.43
colorectal cancer KRAS_12 PTEN Inactivating mutation 271 17 TMB quintile 4 0.28 -0.65 1.20 1473.42 1.00 512 263 9 8 TRUE 0.25
colorectal cancer KRAS_12 PTEN Inactivating mutation 227 44 TMB quintile 5 -1.13 -2.02 -0.40 1359.38 1.00 372 220 37 7 TRUE 2.29
colorectal cancer KRAS_12 PTEN Inactivating mutation 20 57 TMB quintile 6 -0.92 -2.08 0.10 1303.20 1.00 86 16 53 4 TRUE 1.03
uterine cancer KRAS_12 PTEN Inactivating mutation 25 35 TMB quintile 3 0.09 -0.99 1.08 1608.21 1.00 190 21 31 4 TRUE 0.06
uterine cancer KRAS_12 PTEN Inactivating mutation 41 72 TMB quintile 4 0.15 -0.52 0.81 1549.65 1.00 145 28 59 13 TRUE 0.19
uterine cancer KRAS_12 PTEN Inactivating mutation 62 190 TMB quintile 5 0.49 -0.06 1.05 1501.09 1.00 103 19 147 43 TRUE 1.03
colorectal cancer KRAS_12 PTEN Inactivating mutation 518 118 TMB overall -0.54 -2.17 1.33 1487.31 1.00 970 499 99 19 TRUE 0.27
uterine cancer KRAS_12 PTEN Inactivating mutation 130 338 TMB overall 0.23 -0.91 1.30 1491.58 1.00 468 68 276 62 TRUE 0.16
colorectal cancer KRAS_12 ARID1A Inactivating mutation 272 24 TMB quintile 4 0.00 -0.89 0.79 1387.19 1.00 505 263 15 9 TRUE 0.00
colorectal cancer KRAS_12 ARID1A Inactivating mutation 228 87 TMB quintile 5 -0.70 -1.23 -0.19 1226.49 1.00 345 208 67 20 TRUE 2.02
colorectal cancer KRAS_12 ARID1A Inactivating mutation 21 96 TMB quintile 6 -0.62 -1.60 0.23 1486.95 1.00 63 12 87 9 TRUE 0.75
non-small cell lung cancer KRAS_12 ARID1A Inactivating mutation 230 34 TMB quintile 4 -0.43 -1.18 0.21 1542.93 1.00 506 223 27 7 TRUE 0.67
non-small cell lung cancer KRAS_12 ARID1A Inactivating mutation 399 103 TMB quintile 5 -0.10 -0.52 0.32 1629.49 1.00 759 367 71 32 TRUE 0.19
pancreatic cancer KRAS_12 ARID1A Inactivating mutation 252 13 TMB quintile 2 -0.89 -1.80 -0.07 1509.25 1.00 87 246 7 6 TRUE 1.36
pancreatic cancer KRAS_12 ARID1A Inactivating mutation 419 42 TMB quintile 3 0.10 -0.60 0.81 1511.20 1.00 99 383 6 36 TRUE 0.10
pancreatic cancer KRAS_12 ARID1A Inactivating mutation 217 39 TMB quintile 4 -0.21 -0.86 0.44 1433.78 1.00 55 189 11 28 TRUE 0.27
pancreatic cancer KRAS_12 ARID1A Inactivating mutation 35 14 TMB quintile 5 -0.06 -0.93 0.89 1675.92 1.00 17 27 6 8 TRUE 0.05
uterine cancer KRAS_12 ARID1A Inactivating mutation 24 26 TMB quintile 3 0.52 -0.57 1.54 1509.79 1.00 196 20 22 4 TRUE 0.47
uterine cancer KRAS_12 ARID1A Inactivating mutation 42 69 TMB quintile 4 1.33 0.67 2.05 1537.47 1.00 149 19 46 23 TRUE 3.80
uterine cancer KRAS_12 ARID1A Inactivating mutation 70 284 TMB quintile 5 0.90 0.20 1.70 1419.97 1.00 65 8 222 62 TRUE 1.73
colorectal cancer KRAS_12 ARID1A Inactivating mutation 521 207 TMB overall -0.44 -2.20 1.22 1639.51 1.00 913 483 169 38 TRUE 0.21
non-small cell lung cancer KRAS_12 ARID1A Inactivating mutation 629 137 TMB overall -0.26 -1.31 0.68 1417.29 1.00 1265 590 98 39 TRUE 0.23
pancreatic cancer KRAS_12 ARID1A Inactivating mutation 923 108 TMB overall -0.27 -1.04 0.58 1472.95 1.00 258 845 30 78 TRUE 0.30
uterine cancer KRAS_12 ARID1A Inactivating mutation 139 454 TMB overall 0.77 -0.87 2.50 1469.76 1.00 422 47 362 92 TRUE 0.45
uterine cancer KRAS_12 PIK3R1 Inactivating mutation 24 13 TMB quintile 3 -1.10 -3.46 0.43 1656.60 1.00 204 24 13 0 TRUE 0.54
uterine cancer KRAS_12 PIK3R1 Inactivating mutation 40 32 TMB quintile 4 -0.50 -1.58 0.43 1656.77 1.00 165 36 28 4 TRUE 0.49
uterine cancer KRAS_12 PIK3R1 Inactivating mutation 53 57 TMB quintile 5 0.02 -0.74 0.74 1327.58 1.00 178 41 45 12 TRUE 0.02
uterine cancer KRAS_12 PIK3R1 Inactivating mutation 119 116 TMB overall -0.64 -2.10 0.49 1408.70 1.00 594 103 100 16 TRUE 0.47
pancreatic cancer KRAS_12 SMAD4 Inactivating mutation 252 18 TMB quintile 2 0.67 -0.16 1.79 1414.79 1.00 93 235 1 17 TRUE 0.76
pancreatic cancer KRAS_12 SMAD4 Inactivating mutation 420 78 TMB quintile 3 0.47 -0.12 1.05 1213.52 1.00 92 355 13 65 TRUE 0.92
pancreatic cancer KRAS_12 SMAD4 Inactivating mutation 216 44 TMB quintile 4 0.59 -0.15 1.29 1365.30 1.00 57 180 8 36 TRUE 1.01
pancreatic cancer KRAS_12 SMAD4 Inactivating mutation 35 13 TMB quintile 5 1.07 0.14 2.15 1469.60 1.00 20 24 2 11 TRUE 1.48
pancreatic cancer KRAS_12 SMAD4 Inactivating mutation 923 153 TMB overall 0.68 -0.07 1.50 1422.78 1.00 262 794 24 129 TRUE 1.03
non-small cell lung cancer KRAS_12 RB1 Inactivating mutation 130 28 TMB quintile 3 -1.47 -2.51 -0.61 1474.09 1.00 469 129 27 1 TRUE 2.78
non-small cell lung cancer KRAS_12 RB1 Inactivating mutation 230 40 TMB quintile 4 -1.38 -2.17 -0.66 1351.66 1.00 496 226 36 4 TRUE 3.52
non-small cell lung cancer KRAS_12 RB1 Inactivating mutation 395 86 TMB quintile 5 -1.16 -1.77 -0.60 1384.09 1.00 757 382 73 13 TRUE 4.05
non-small cell lung cancer KRAS_12 RB1 Inactivating mutation 755 154 TMB overall -1.33 -2.10 -0.60 1511.20 1.00 1722 737 136 18 TRUE 3.39
uterine cancer KRAS_12 JAK1 Inactivating mutation 52 76 TMB quintile 5 -0.02 -0.66 0.61 1488.69 1.00 168 38 62 14 TRUE 0.02
uterine cancer KRAS_12 JAK1 Inactivating mutation 54 101 TMB overall -0.08 -2.33 2.06 1328.43 1.00 209 39 86 15 TRUE 0.03
uterine cancer KRAS_12 CTCF Inactivating mutation 51 83 TMB quintile 5 -0.05 -0.69 0.56 1434.70 1.00 147 35 67 16 FALSE 0.05
uterine cancer KRAS_12 CTCF Inactivating mutation 53 109 TMB overall -0.82 -3.96 1.40 1338.46 1.00 183 37 93 16 FALSE 0.26
non-small cell lung cancer KRAS_12 NF1 Inactivating mutation 130 18 TMB quintile 3 -2.21 -4.45 -0.86 1485.60 1.00 478 130 18 0 TRUE 1.85
non-small cell lung cancer KRAS_12 NF1 Inactivating mutation 230 48 TMB quintile 4 -2.12 -3.35 -1.12 1504.54 1.00 494 228 46 2 TRUE 3.59
non-small cell lung cancer KRAS_12 NF1 Inactivating mutation 396 108 TMB quintile 5 -1.12 -1.69 -0.62 1468.01 1.00 748 379 91 17 TRUE 4.34
non-small cell lung cancer KRAS_12 NF1 Inactivating mutation 756 174 TMB overall -1.80 -3.20 -0.76 1586.82 1.00 1720 737 155 19 TRUE 2.31
colorectal cancer KRAS_12 APC Inactivating mutation 18 77 TMB quintile 2 -0.87 -1.74 -0.07 1541.18 1.00 55 13 72 5 TRUE 1.40
colorectal cancer KRAS_12 APC Inactivating mutation 173 422 TMB quintile 3 -0.20 -0.57 0.18 1416.45 1.00 108 54 303 119 TRUE 0.54
colorectal cancer KRAS_12 APC Inactivating mutation 374 936 TMB quintile 4 -0.13 -0.46 0.21 1484.69 1.00 97 60 622 314 TRUE 0.36
colorectal cancer KRAS_12 APC Inactivating mutation 360 781 TMB quintile 5 0.45 0.12 0.78 1271.10 1.00 116 48 469 312 TRUE 2.12
colorectal cancer KRAS_12 APC Inactivating mutation 31 151 TMB quintile 6 0.11 -0.53 0.87 1379.09 1.00 61 7 127 24 TRUE 0.12
colorectal cancer KRAS_12 APC Inactivating mutation 956 2367 TMB overall -0.14 -0.80 0.50 1320.12 1.00 437 182 1593 774 TRUE 0.16
colorectal cancer KRAS_12 KMT2D Inactivating mutation 229 46 TMB quintile 5 -0.93 -1.67 -0.20 1295.73 1.00 371 220 37 9 FALSE 1.93
colorectal cancer KRAS_12 KMT2D Inactivating mutation 21 111 TMB quintile 6 -0.56 -1.45 0.35 1488.80 1.00 56 10 100 11 FALSE 0.65
uterine cancer KRAS_12 KMT2D Inactivating mutation 49 88 TMB quintile 5 -1.16 -2.05 -0.34 1563.34 1.00 142 41 80 8 FALSE 2.14
colorectal cancer KRAS_12 KMT2D Inactivating mutation 250 157 TMB overall -0.68 -3.14 1.96 1380.69 1.00 427 230 137 20 FALSE 0.23
uterine cancer KRAS_12 KMT2D Inactivating mutation 51 117 TMB overall -1.56 -4.57 0.80 1456.07 1.00 179 43 109 8 FALSE 0.64
non-small cell lung cancer KRAS_12 SETD2 Inactivating mutation 131 16 TMB quintile 3 -0.22 -1.26 0.57 1436.56 1.00 485 129 14 2 FALSE 0.20
non-small cell lung cancer KRAS_12 SETD2 Inactivating mutation 230 34 TMB quintile 4 -0.15 -0.87 0.49 1564.90 1.00 510 222 26 8 FALSE 0.18
non-small cell lung cancer KRAS_12 SETD2 Inactivating mutation 399 50 TMB quintile 5 0.32 -0.22 0.86 1599.57 1.00 804 377 28 22 FALSE 0.62
non-small cell lung cancer KRAS_12 SETD2 Inactivating mutation 760 100 TMB overall -0.03 -0.82 0.65 1536.34 1.00 1799 728 68 32 FALSE 0.02
non-small cell lung cancer KRAS_12 RBM10 Inactivating mutation 75 26 TMB quintile 2 0.47 -0.20 1.05 1413.25 1.00 345 70 21 5 FALSE 0.89
non-small cell lung cancer KRAS_12 RBM10 Inactivating mutation 130 40 TMB quintile 3 0.59 0.02 1.10 1436.88 1.00 468 118 28 12 FALSE 1.55
non-small cell lung cancer KRAS_12 RBM10 Inactivating mutation 231 76 TMB quintile 4 0.81 0.41 1.23 1377.33 1.00 492 195 40 36 FALSE 4.17
non-small cell lung cancer KRAS_12 RBM10 Inactivating mutation 398 133 TMB quintile 5 0.92 0.58 1.23 1342.42 1.00 767 328 63 70 FALSE 7.47
non-small cell lung cancer KRAS_12 RBM10 Inactivating mutation 834 275 TMB overall 0.70 0.20 1.18 1522.87 1.00 2072 711 152 123 FALSE 2.41
non-small cell lung cancer KRAS_12 CDKN2A Inactivating mutation 130 17 TMB quintile 3 0.28 -0.63 1.27 1435.46 1.00 485 124 11 6 TRUE 0.24
non-small cell lung cancer KRAS_12 CDKN2A Inactivating mutation 230 27 TMB quintile 4 -0.13 -0.92 0.61 1406.93 1.00 513 222 19 8 TRUE 0.13
non-small cell lung cancer KRAS_12 CDKN2A Inactivating mutation 396 96 TMB quintile 5 -0.74 -1.29 -0.26 1187.65 1.01 751 379 79 17 TRUE 2.25
pancreatic cancer KRAS_12 CDKN2A Inactivating mutation 252 25 TMB quintile 2 0.77 0.01 1.63 1465.13 1.00 91 230 3 22 TRUE 1.24
pancreatic cancer KRAS_12 CDKN2A Inactivating mutation 421 102 TMB quintile 3 1.26 0.67 1.92 1440.96 1.00 98 326 7 95 TRUE 4.05
pancreatic cancer KRAS_12 CDKN2A Inactivating mutation 220 63 TMB quintile 4 0.91 0.21 1.61 1604.04 1.00 55 167 10 53 TRUE 2.02
non-small cell lung cancer KRAS_12 CDKN2A Inactivating mutation 756 140 TMB overall -0.21 -1.22 0.81 1412.08 1.00 1749 725 109 31 TRUE 0.16
pancreatic cancer KRAS_12 CDKN2A Inactivating mutation 893 190 TMB overall 0.98 0.15 1.83 1337.87 1.00 244 723 20 170 TRUE 1.65
colorectal cancer KRAS_12 SOX9 Inactivating mutation 144 14 TMB quintile 3 -0.38 -1.49 0.58 1477.02 1.00 332 141 11 3 FALSE 0.34
colorectal cancer KRAS_12 SOX9 Inactivating mutation 272 73 TMB quintile 4 0.23 -0.25 0.67 1571.61 1.00 476 243 44 29 FALSE 0.48
colorectal cancer KRAS_12 SOX9 Inactivating mutation 231 88 TMB quintile 5 0.27 -0.18 0.73 1517.44 1.00 351 194 51 37 FALSE 0.64
colorectal cancer KRAS_12 SOX9 Inactivating mutation 18 43 TMB quintile 6 0.33 -0.53 1.20 1242.42 1.00 93 11 36 7 FALSE 0.34
colorectal cancer KRAS_12 SOX9 Inactivating mutation 665 218 TMB overall 0.12 -0.81 1.07 1575.28 1.00 1252 589 142 76 FALSE 0.10
non-small cell lung cancer KRAS_12 STK11 Inactivating mutation 132 59 TMB quintile 3 0.95 0.45 1.45 1229.75 1.00 461 108 35 24 TRUE 3.85
non-small cell lung cancer KRAS_12 STK11 Inactivating mutation 230 106 TMB quintile 4 1.20 0.81 1.60 1558.31 1.00 486 170 46 60 TRUE 8.17
non-small cell lung cancer KRAS_12 STK11 Inactivating mutation 396 183 TMB quintile 5 0.41 0.07 0.74 1572.03 1.00 716 326 113 70 TRUE 1.83
non-small cell lung cancer KRAS_12 STK11 Inactivating mutation 758 348 TMB overall 0.85 0.25 1.46 1422.00 1.00 1663 604 194 154 TRUE 2.25
non-small cell lung cancer KRAS_12 KEAP1 Inactivating mutation 230 35 TMB quintile 4 0.72 0.06 1.47 1058.37 1.00 516 211 16 19 FALSE 1.34
non-small cell lung cancer KRAS_12 KEAP1 Inactivating mutation 395 69 TMB quintile 5 0.17 -0.34 0.68 564.08 1.00 781 373 47 22 FALSE 0.27
non-small cell lung cancer KRAS_12 KEAP1 Inactivating mutation 625 104 TMB overall 0.45 -0.46 1.51 1290.78 1.00 1297 584 63 41 FALSE 0.45
colorectal cancer KRAS_12 RNF43 Inactivating mutation 271 21 TMB quintile 4 -0.63 -1.66 0.31 1362.12 1.00 505 266 16 5 TRUE 0.66
colorectal cancer KRAS_12 RNF43 Inactivating mutation 231 58 TMB quintile 5 -0.87 -1.57 -0.28 1203.71 1.00 358 219 46 12 TRUE 2.12
colorectal cancer KRAS_12 RNF43 Inactivating mutation 21 113 TMB quintile 6 -0.44 -1.36 0.43 1538.86 1.00 51 9 101 12 TRUE 0.48
colorectal cancer KRAS_12 RNF43 Inactivating mutation 523 192 TMB overall -0.64 -2.58 1.34 1469.90 1.00 914 494 163 29 TRUE 0.30
colorectal cancer KRAS_12 B2M Inactivating mutation 215 45 TMB quintile 5 -0.48 -1.17 0.15 1590.04 1.00 356 203 33 12 FALSE 0.81
colorectal cancer KRAS_12 B2M Inactivating mutation 23 66 TMB quintile 6 -0.01 -0.90 0.87 1475.31 1.00 79 13 56 10 FALSE 0.01
colorectal cancer KRAS_12 B2M Inactivating mutation 238 111 TMB overall -0.25 -2.57 2.17 1394.08 1.00 435 216 89 22 FALSE 0.08
colorectal cancer KRAS_12 TCF7L2 Inactivating mutation 130 13 TMB quintile 3 0.17 -0.90 1.15 1392.98 1.00 301 125 8 5 FALSE 0.13
colorectal cancer KRAS_12 TCF7L2 Inactivating mutation 248 39 TMB quintile 4 0.34 -0.32 0.95 1529.11 1.00 450 231 22 17 FALSE 0.53
colorectal cancer KRAS_12 TCF7L2 Inactivating mutation 213 57 TMB quintile 5 -0.66 -1.27 -0.08 1656.43 1.00 323 200 44 13 FALSE 1.47
colorectal cancer KRAS_12 TCF7L2 Inactivating mutation 17 48 TMB quintile 6 0.61 -0.31 1.52 1630.06 1.00 80 8 39 9 FALSE 0.70
colorectal cancer KRAS_12 TCF7L2 Inactivating mutation 608 157 TMB overall 0.14 -1.01 1.31 1680.12 1.00 1154 564 113 44 FALSE 0.09
non-small cell lung cancer KRAS_12 MGA Inactivating mutation 216 16 TMB quintile 4 0.34 -0.53 1.17 1382.83 1.00 453 209 9 7 FALSE 0.35
non-small cell lung cancer KRAS_12 MGA Inactivating mutation 364 73 TMB quintile 5 0.29 -0.18 0.79 1468.48 1.00 697 336 45 28 FALSE 0.62
non-small cell lung cancer KRAS_12 MGA Inactivating mutation 580 89 TMB overall 0.28 -1.05 1.63 1383.22 1.00 1150 545 54 35 FALSE 0.18
uterine cancer KRAS_12 ZFHX3 Inactivating mutation 36 12 TMB quintile 4 -0.26 -1.70 0.98 1524.56 1.00 159 34 10 2 FALSE 0.15
uterine cancer KRAS_12 ZFHX3 Inactivating mutation 46 66 TMB quintile 5 0.16 -0.56 0.84 1490.06 1.00 159 33 53 13 FALSE 0.18
uterine cancer KRAS_12 ZFHX3 Inactivating mutation 84 104 TMB overall -0.11 -1.80 1.47 1418.03 1.00 357 68 88 16 FALSE 0.05
colorectal cancer KRAS_12 AMER1 Inactivating mutation 271 31 TMB quintile 4 0.98 0.30 1.67 1463.85 1.00 508 252 12 19 FALSE 2.30
colorectal cancer KRAS_12 AMER1 Inactivating mutation 227 47 TMB quintile 5 0.38 -0.20 0.95 1673.61 1.00 373 206 26 21 FALSE 0.72
colorectal cancer KRAS_12 AMER1 Inactivating mutation 18 27 TMB quintile 6 -0.03 -1.25 1.09 1517.07 1.00 99 15 24 3 FALSE 0.02
colorectal cancer KRAS_12 AMER1 Inactivating mutation 516 105 TMB overall 0.46 -1.06 1.80 1420.86 1.00 980 473 62 43 FALSE 0.30
non-small cell lung cancer RAS_12C TP53 Inactivating mutation 13 49 TMB quintile 2 -0.11 -1.22 1.11 1320.79 1.00 382 10 46 3 TRUE 0.07
non-small cell lung cancer RAS_12C TP53 Inactivating mutation 18 116 TMB quintile 3 -0.92 -2.30 0.10 1363.93 1.00 497 17 115 1 TRUE 0.95
non-small cell lung cancer RAS_12C TP53 Inactivating mutation 42 145 TMB quintile 4 -1.07 -2.17 -0.25 1411.80 1.00 581 40 143 2 TRUE 1.49
non-small cell lung cancer RAS_12C TP53 Inactivating mutation 93 346 TMB quintile 5 -0.35 -0.85 0.12 1287.59 1.00 816 72 325 21 TRUE 0.79
non-small cell lung cancer RAS_12C TP53 Inactivating mutation 166 656 TMB overall -0.62 -1.52 0.20 1195.04 1.00 2276 139 629 27 TRUE 0.82
non-small cell lung cancer RAS_12C SMARCA4 Inactivating mutation 18 12 TMB quintile 3 1.39 -0.06 2.78 1241.41 1.00 598 16 10 2 FALSE 1.26
non-small cell lung cancer RAS_12C SMARCA4 Inactivating mutation 42 28 TMB quintile 4 1.60 0.67 2.55 1417.67 1.00 699 35 21 7 FALSE 3.05
non-small cell lung cancer RAS_12C SMARCA4 Inactivating mutation 94 94 TMB quintile 5 0.00 -0.89 0.78 1424.92 1.00 1044 88 88 6 FALSE 0.00
non-small cell lung cancer RAS_12C SMARCA4 Inactivating mutation 154 134 TMB overall 0.98 -0.41 2.45 1251.31 1.00 2341 139 119 15 FALSE 0.76
non-small cell lung cancer RAS_12C ARID1A Inactivating mutation 42 34 TMB quintile 4 -0.38 -1.97 0.73 1303.52 1.00 688 41 33 1 TRUE 0.24
non-small cell lung cancer RAS_12C ARID1A Inactivating mutation 94 103 TMB quintile 5 0.05 -0.69 0.72 1363.23 1.00 1041 85 94 9 TRUE 0.05
non-small cell lung cancer RAS_12C ARID1A Inactivating mutation 136 137 TMB overall -0.16 -1.58 1.05 1486.99 1.00 1729 126 127 10 TRUE 0.09
non-small cell lung cancer RAS_12C RB1 Inactivating mutation 18 28 TMB quintile 3 -1.63 -3.66 0.27 1498.46 1.00 581 17 27 1 TRUE 1.03
non-small cell lung cancer RAS_12C RB1 Inactivating mutation 42 40 TMB quintile 4 -2.07 -4.23 -0.51 1431.27 1.00 680 42 40 0 TRUE 1.52
non-small cell lung cancer RAS_12C RB1 Inactivating mutation 93 86 TMB quintile 5 -1.96 -3.72 -0.63 1565.35 1.00 1047 92 85 1 TRUE 1.78
non-small cell lung cancer RAS_12C RB1 Inactivating mutation 153 154 TMB overall -1.87 -3.74 -0.36 1561.28 1.00 2308 151 152 2 TRUE 1.48
non-small cell lung cancer RAS_12C NF1 Inactivating mutation 18 18 TMB quintile 3 -3.22 -6.43 -0.77 1300.89 1.00 590 18 18 0 TRUE 1.53
non-small cell lung cancer RAS_12C NF1 Inactivating mutation 42 48 TMB quintile 4 -3.28 -6.58 -1.08 1431.93 1.00 680 42 48 0 TRUE 1.72
non-small cell lung cancer RAS_12C NF1 Inactivating mutation 93 108 TMB quintile 5 -2.98 -5.70 -1.18 1305.17 1.00 1035 92 107 1 TRUE 1.97
non-small cell lung cancer RAS_12C NF1 Inactivating mutation 153 174 TMB overall -3.13 -5.78 -1.02 1297.52 1.00 2305 152 173 1 TRUE 1.91
non-small cell lung cancer RAS_12C SETD2 Inactivating mutation 18 16 TMB quintile 3 -0.27 -2.02 1.02 1535.13 1.00 596 18 16 0 FALSE 0.13
non-small cell lung cancer RAS_12C SETD2 Inactivating mutation 42 34 TMB quintile 4 -0.26 -1.79 0.82 1424.62 1.00 691 41 33 1 FALSE 0.16
non-small cell lung cancer RAS_12C SETD2 Inactivating mutation 95 50 TMB quintile 5 0.21 -0.79 1.05 1472.30 1.00 1092 89 44 6 FALSE 0.19
non-small cell lung cancer RAS_12C SETD2 Inactivating mutation 155 100 TMB overall -0.12 -1.51 0.98 1625.43 1.00 2379 148 93 7 FALSE 0.07
non-small cell lung cancer RAS_12C RBM10 Inactivating mutation 13 26 TMB quintile 2 -0.13 -1.69 0.94 1600.08 1.00 402 13 26 0 FALSE 0.07
non-small cell lung cancer RAS_12C RBM10 Inactivating mutation 18 40 TMB quintile 3 -0.19 -1.66 0.85 1526.46 1.00 568 18 40 0 FALSE 0.12
non-small cell lung cancer RAS_12C RBM10 Inactivating mutation 43 76 TMB quintile 4 0.59 -0.10 1.34 1587.84 1.00 653 34 67 9 FALSE 0.97
non-small cell lung cancer RAS_12C RBM10 Inactivating mutation 94 133 TMB quintile 5 0.20 -0.41 0.77 1628.65 1.00 1013 82 121 12 FALSE 0.29
non-small cell lung cancer RAS_12C RBM10 Inactivating mutation 168 275 TMB overall 0.12 -0.78 0.87 1500.61 1.00 2636 147 254 21 FALSE 0.10
non-small cell lung cancer RAS_12C CDKN2A Inactivating mutation 18 17 TMB quintile 3 -1.52 -4.14 0.33 1537.03 1.00 591 18 17 0 TRUE 0.72
non-small cell lung cancer RAS_12C CDKN2A Inactivating mutation 42 27 TMB quintile 4 -1.66 -4.05 0.09 1385.31 1.00 693 42 27 0 TRUE 0.85
non-small cell lung cancer RAS_12C CDKN2A Inactivating mutation 94 96 TMB quintile 5 -0.97 -2.27 0.01 1496.01 1.00 1040 90 92 4 TRUE 1.05
non-small cell lung cancer RAS_12C CDKN2A Inactivating mutation 154 140 TMB overall -1.36 -3.22 0.15 1487.89 1.00 2324 150 136 4 TRUE 0.90
non-small cell lung cancer RAS_12C STK11 Inactivating mutation 19 59 TMB quintile 3 0.92 0.06 1.89 1404.60 1.00 556 13 53 6 TRUE 1.28
non-small cell lung cancer RAS_12C STK11 Inactivating mutation 42 106 TMB quintile 4 0.52 -0.16 1.17 1532.40 1.00 623 33 97 9 TRUE 0.89
non-small cell lung cancer RAS_12C STK11 Inactivating mutation 93 183 TMB quintile 5 0.25 -0.33 0.74 1447.59 1.00 964 78 168 15 TRUE 0.44
non-small cell lung cancer RAS_12C STK11 Inactivating mutation 154 348 TMB overall 0.56 -0.23 1.43 1430.51 1.00 2143 124 318 30 TRUE 0.72
non-small cell lung cancer RAS_12C KEAP1 Inactivating mutation 42 35 TMB quintile 4 -0.13 -1.27 0.83 1171.73 1.00 687 40 33 2 FALSE 0.09
non-small cell lung cancer RAS_12C KEAP1 Inactivating mutation 93 69 TMB quintile 5 -0.14 -1.04 0.69 1163.91 1.00 1066 88 64 5 FALSE 0.12
non-small cell lung cancer RAS_12C KEAP1 Inactivating mutation 135 104 TMB overall -0.14 -1.23 0.84 1159.56 1.00 1753 128 97 7 FALSE 0.10
non-small cell lung cancer RAS_12C MGA Inactivating mutation 40 16 TMB quintile 4 -0.86 -4.63 1.03 1368.44 1.00 622 40 16 0 FALSE 0.25
non-small cell lung cancer RAS_12C MGA Inactivating mutation 85 73 TMB quintile 5 0.56 -0.18 1.25 1534.67 1.00 958 75 63 10 FALSE 0.87
non-small cell lung cancer RAS_12C MGA Inactivating mutation 125 89 TMB overall -0.16 -3.15 1.95 1650.70 1.00 1580 115 79 10 FALSE 0.05
non-small cell lung cancer KRAS_12C TP53 Inactivating mutation 27 49 TMB quintile 2 -0.46 -1.47 0.50 1256.57 1.00 368 24 46 3 TRUE 0.43
non-small cell lung cancer KRAS_12C TP53 Inactivating mutation 46 116 TMB quintile 3 -0.67 -1.44 0.08 1607.80 1.00 473 41 111 5 TRUE 1.09
non-small cell lung cancer KRAS_12C TP53 Inactivating mutation 127 145 TMB quintile 4 -0.72 -1.28 -0.22 1353.48 1.00 508 113 131 14 TRUE 2.03
non-small cell lung cancer KRAS_12C TP53 Inactivating mutation 222 346 TMB quintile 5 -0.63 -0.96 -0.29 1508.21 1.00 707 181 305 41 TRUE 3.46
non-small cell lung cancer KRAS_12C TP53 Inactivating mutation 422 656 TMB overall -0.62 -1.35 0.12 1666.80 1.00 2056 359 593 63 TRUE 1.03
non-small cell lung cancer KRAS_12C SMARCA4 Inactivating mutation 46 12 TMB quintile 3 1.29 0.02 2.48 1441.52 1.00 572 42 8 4 FALSE 1.41
non-small cell lung cancer KRAS_12C SMARCA4 Inactivating mutation 127 28 TMB quintile 4 0.81 0.02 1.57 1426.62 1.00 616 118 19 9 FALSE 1.41
non-small cell lung cancer KRAS_12C SMARCA4 Inactivating mutation 223 94 TMB quintile 5 -0.15 -0.76 0.40 1398.43 1.00 923 209 80 14 FALSE 0.21
non-small cell lung cancer KRAS_12C SMARCA4 Inactivating mutation 396 134 TMB overall 0.66 -0.58 1.95 1281.87 1.00 2111 369 107 27 FALSE 0.51
non-small cell lung cancer KRAS_12C ARID1A Inactivating mutation 127 34 TMB quintile 4 -0.57 -1.66 0.22 1401.95 1.00 605 124 31 3 TRUE 0.65
non-small cell lung cancer KRAS_12C ARID1A Inactivating mutation 224 103 TMB quintile 5 -0.13 -0.68 0.38 1515.71 1.00 920 206 85 18 TRUE 0.20
non-small cell lung cancer KRAS_12C ARID1A Inactivating mutation 351 137 TMB overall -0.34 -1.59 0.76 1328.68 1.00 1525 330 116 21 TRUE 0.26
non-small cell lung cancer KRAS_12C RB1 Inactivating mutation 46 28 TMB quintile 3 -1.20 -2.49 0.00 1482.76 1.00 553 45 27 1 TRUE 1.22
non-small cell lung cancer KRAS_12C RB1 Inactivating mutation 127 40 TMB quintile 4 -1.35 -2.50 -0.38 1514.85 1.00 597 125 38 2 TRUE 1.85
non-small cell lung cancer KRAS_12C RB1 Inactivating mutation 222 86 TMB quintile 5 -1.21 -2.02 -0.49 1549.89 1.00 923 216 80 6 TRUE 2.65
non-small cell lung cancer KRAS_12C RB1 Inactivating mutation 395 154 TMB overall -1.24 -2.26 -0.15 1365.07 1.00 2073 386 145 9 TRUE 1.73
non-small cell lung cancer KRAS_12C NF1 Inactivating mutation 46 18 TMB quintile 3 -1.65 -3.99 -0.06 1602.29 1.00 562 46 18 0 TRUE 1.05
non-small cell lung cancer KRAS_12C NF1 Inactivating mutation 127 48 TMB quintile 4 -1.56 -2.92 -0.51 1499.16 1.00 597 125 46 2 TRUE 2.00
non-small cell lung cancer KRAS_12C NF1 Inactivating mutation 223 108 TMB quintile 5 -1.07 -1.75 -0.42 1449.19 1.00 913 214 99 9 TRUE 2.71
non-small cell lung cancer KRAS_12C NF1 Inactivating mutation 396 174 TMB overall -1.42 -2.80 -0.28 1439.21 1.00 2072 385 163 11 TRUE 1.54
non-small cell lung cancer KRAS_12C SETD2 Inactivating mutation 46 16 TMB quintile 3 -0.53 -2.37 0.69 1068.13 1.00 568 46 16 0 FALSE 0.29
non-small cell lung cancer KRAS_12C SETD2 Inactivating mutation 127 34 TMB quintile 4 -0.29 -1.30 0.55 1414.24 1.00 609 123 30 4 FALSE 0.27
non-small cell lung cancer KRAS_12C SETD2 Inactivating mutation 225 50 TMB quintile 5 0.39 -0.26 1.00 1560.23 1.00 970 211 36 14 FALSE 0.65
non-small cell lung cancer KRAS_12C SETD2 Inactivating mutation 398 100 TMB overall -0.14 -1.36 0.85 1336.33 1.00 2147 380 82 18 FALSE 0.10
non-small cell lung cancer KRAS_12C RBM10 Inactivating mutation 27 26 TMB quintile 2 0.05 -1.10 0.93 1357.92 1.00 389 26 25 1 FALSE 0.04
non-small cell lung cancer KRAS_12C RBM10 Inactivating mutation 46 40 TMB quintile 3 0.16 -0.82 0.93 1497.03 1.00 543 43 37 3 FALSE 0.14
non-small cell lung cancer KRAS_12C RBM10 Inactivating mutation 128 76 TMB quintile 4 0.70 0.21 1.20 1554.44 1.00 581 106 54 22 FALSE 2.26
non-small cell lung cancer KRAS_12C RBM10 Inactivating mutation 223 133 TMB quintile 5 0.42 0.01 0.81 1353.42 1.00 904 191 101 32 FALSE 1.40
non-small cell lung cancer KRAS_12C RBM10 Inactivating mutation 424 275 TMB overall 0.33 -0.41 1.00 1480.32 1.00 2417 366 217 58 FALSE 0.45
non-small cell lung cancer KRAS_12C CDKN2A Inactivating mutation 46 17 TMB quintile 3 0.21 -1.13 1.45 1423.92 1.00 566 43 14 3 TRUE 0.12
non-small cell lung cancer KRAS_12C CDKN2A Inactivating mutation 127 27 TMB quintile 4 -0.76 -2.02 0.22 1552.91 1.00 610 125 25 2 TRUE 0.73
non-small cell lung cancer KRAS_12C CDKN2A Inactivating mutation 223 96 TMB quintile 5 -0.64 -1.31 -0.05 1408.15 1.00 917 213 86 10 TRUE 1.30
non-small cell lung cancer KRAS_12C CDKN2A Inactivating mutation 396 140 TMB overall -0.39 -1.53 0.88 1455.49 1.00 2093 381 125 15 TRUE 0.29
non-small cell lung cancer KRAS_12C STK11 Inactivating mutation 47 59 TMB quintile 3 0.88 0.23 1.56 1283.96 1.00 532 37 49 10 TRUE 1.96
non-small cell lung cancer KRAS_12C STK11 Inactivating mutation 127 106 TMB quintile 4 1.13 0.70 1.58 1463.84 1.00 566 90 69 37 TRUE 6.11
non-small cell lung cancer KRAS_12C STK11 Inactivating mutation 223 183 TMB quintile 5 0.13 -0.28 0.54 1525.38 1.00 853 189 149 34 TRUE 0.27
non-small cell lung cancer KRAS_12C STK11 Inactivating mutation 397 348 TMB overall 0.70 -0.13 1.50 1533.29 1.00 1951 316 267 81 TRUE 1.09
non-small cell lung cancer KRAS_12C KEAP1 Inactivating mutation 127 35 TMB quintile 4 0.35 -0.24 1.03 737.73 1.00 610 117 25 10 FALSE 0.53
non-small cell lung cancer KRAS_12C KEAP1 Inactivating mutation 222 69 TMB quintile 5 0.13 -0.45 0.63 1101.97 1.00 944 210 57 12 FALSE 0.19
non-small cell lung cancer KRAS_12C KEAP1 Inactivating mutation 349 104 TMB overall 0.22 -0.51 0.96 957.36 1.00 1554 327 82 22 FALSE 0.25
non-small cell lung cancer KRAS_12C MGA Inactivating mutation 121 16 TMB quintile 4 0.55 -0.36 1.46 1580.56 1.00 546 116 11 5 FALSE 0.64
non-small cell lung cancer KRAS_12C MGA Inactivating mutation 204 73 TMB quintile 5 0.50 -0.06 1.03 1539.07 1.00 848 185 54 19 FALSE 1.15
non-small cell lung cancer KRAS_12C MGA Inactivating mutation 325 89 TMB overall 0.52 -0.75 1.81 1546.97 1.00 1394 301 65 24 FALSE 0.38
colorectal cancer RAS_13 TP53 Inactivating mutation 10 39 TMB quintile 2 -0.56 -1.62 0.22 1446.87 1.00 88 10 39 0 TRUE 0.61
colorectal cancer RAS_13 TP53 Inactivating mutation 25 146 TMB quintile 3 -0.48 -1.22 0.17 1580.94 1.00 320 21 142 4 TRUE 0.76
colorectal cancer RAS_13 TP53 Inactivating mutation 62 208 TMB quintile 4 -0.06 -0.58 0.47 1467.20 1.00 542 45 191 17 TRUE 0.09
colorectal cancer RAS_13 TP53 Inactivating mutation 80 108 TMB quintile 5 -0.15 -0.67 0.37 1466.38 1.00 454 67 95 13 TRUE 0.25
colorectal cancer RAS_13 TP53 Inactivating mutation 16 31 TMB quintile 6 0.12 -0.62 0.93 1273.35 1.00 106 10 25 6 TRUE 0.11
colorectal cancer RAS_13 TP53 Inactivating mutation 193 532 TMB overall -0.23 -0.84 0.30 1425.41 1.00 1510 153 492 40 TRUE 0.36
colorectal cancer RAS_13 FBXW7 Inactivating mutation 25 11 TMB quintile 3 -0.16 -1.91 1.27 1397.27 1.00 451 25 11 0 TRUE 0.07
colorectal cancer RAS_13 FBXW7 Inactivating mutation 62 27 TMB quintile 4 0.28 -0.87 1.25 1502.62 1.00 706 59 24 3 TRUE 0.21
colorectal cancer RAS_13 FBXW7 Inactivating mutation 80 49 TMB quintile 5 0.15 -0.62 0.90 1436.67 1.00 507 73 42 7 TRUE 0.15
colorectal cancer RAS_13 FBXW7 Inactivating mutation 16 24 TMB quintile 6 0.70 -0.37 1.71 1061.50 1.00 107 11 19 5 TRUE 0.75
colorectal cancer RAS_13 FBXW7 Inactivating mutation 183 111 TMB overall 0.26 -0.84 1.25 1361.44 1.00 1771 168 96 15 TRUE 0.21
colorectal cancer RAS_13 PTEN Inactivating mutation 62 17 TMB quintile 4 -0.44 -2.39 0.99 1519.51 1.00 714 61 16 1 TRUE 0.22
colorectal cancer RAS_13 PTEN Inactivating mutation 81 44 TMB quintile 5 -0.42 -1.45 0.47 1559.58 1.00 515 77 40 4 TRUE 0.40
colorectal cancer RAS_13 PTEN Inactivating mutation 18 57 TMB quintile 6 0.32 -0.65 1.24 1299.12 1.00 92 10 49 8 TRUE 0.29
colorectal cancer RAS_13 PTEN Inactivating mutation 161 118 TMB overall -0.16 -1.82 1.44 1400.04 1.00 1321 148 105 13 TRUE 0.07
colorectal cancer RAS_13 ARID1A Inactivating mutation 62 24 TMB quintile 4 -2.07 -5.68 0.04 1458.25 1.00 706 62 24 0 TRUE 0.80
colorectal cancer RAS_13 ARID1A Inactivating mutation 80 87 TMB quintile 5 -0.64 -1.46 0.12 1523.42 1.00 480 73 80 7 TRUE 0.95
colorectal cancer RAS_13 ARID1A Inactivating mutation 19 96 TMB quintile 6 0.00 -0.91 0.91 1581.82 1.00 67 8 85 11 TRUE 0.00
colorectal cancer RAS_13 ARID1A Inactivating mutation 161 207 TMB overall -0.88 -3.17 1.13 1481.02 1.00 1253 143 189 18 TRUE 0.40
colorectal cancer RAS_13 APC Inactivating mutation 10 77 TMB quintile 2 0.05 -0.85 0.95 1522.05 1.00 63 5 72 5 TRUE 0.04
colorectal cancer RAS_13 APC Inactivating mutation 26 422 TMB quintile 3 -0.48 -1.21 0.20 1374.21 1.00 150 12 408 14 TRUE 0.74
colorectal cancer RAS_13 APC Inactivating mutation 89 936 TMB quintile 4 0.30 -0.26 0.92 1417.36 1.00 147 10 857 79 TRUE 0.50
colorectal cancer RAS_13 APC Inactivating mutation 133 781 TMB quintile 5 0.90 0.38 1.45 1535.64 1.00 154 10 658 123 TRUE 2.93
colorectal cancer RAS_13 APC Inactivating mutation 25 151 TMB quintile 6 0.55 -0.19 1.33 1502.36 1.00 63 5 131 20 TRUE 0.83
colorectal cancer RAS_13 APC Inactivating mutation 283 2367 TMB overall 0.25 -0.37 0.93 1482.52 1.00 577 42 2126 241 TRUE 0.34
colorectal cancer RAS_13 KMT2D Inactivating mutation 80 46 TMB quintile 5 -0.82 -2.07 0.23 1387.30 1.00 514 77 43 3 FALSE 0.78
colorectal cancer RAS_13 KMT2D Inactivating mutation 19 111 TMB quintile 6 0.00 -0.92 0.96 1543.62 1.00 59 7 99 12 FALSE 0.00
colorectal cancer RAS_13 KMT2D Inactivating mutation 99 157 TMB overall -0.38 -2.90 2.13 1355.22 1.00 573 84 142 15 FALSE 0.12
colorectal cancer RAS_13 SOX9 Inactivating mutation 25 14 TMB quintile 3 0.07 -1.35 1.35 1416.12 1.00 449 24 13 1 FALSE 0.04
colorectal cancer RAS_13 SOX9 Inactivating mutation 62 73 TMB quintile 4 0.17 -0.60 0.90 1519.23 1.00 664 55 66 7 FALSE 0.19
colorectal cancer RAS_13 SOX9 Inactivating mutation 80 88 TMB quintile 5 -0.01 -0.65 0.60 1370.39 1.00 476 69 77 11 FALSE 0.01
colorectal cancer RAS_13 SOX9 Inactivating mutation 17 43 TMB quintile 6 0.30 -0.59 1.23 1605.28 1.00 93 11 37 6 FALSE 0.28
colorectal cancer RAS_13 SOX9 Inactivating mutation 184 218 TMB overall 0.14 -0.84 1.13 1504.41 1.00 1682 159 193 25 FALSE 0.11
colorectal cancer RAS_13 RNF43 Inactivating mutation 62 21 TMB quintile 4 -1.00 -3.28 0.72 1559.34 1.00 710 61 20 1 TRUE 0.49
colorectal cancer RAS_13 RNF43 Inactivating mutation 80 58 TMB quintile 5 -1.56 -3.17 -0.40 1342.40 1.00 499 78 56 2 TRUE 1.52
colorectal cancer RAS_13 RNF43 Inactivating mutation 18 113 TMB quintile 6 -0.67 -1.61 0.25 1380.41 1.00 51 9 104 9 TRUE 0.79
colorectal cancer RAS_13 RNF43 Inactivating mutation 160 192 TMB overall -1.02 -3.39 1.05 1460.21 1.00 1260 148 180 12 TRUE 0.45
colorectal cancer RAS_13 B2M Inactivating mutation 78 45 TMB quintile 5 -0.72 -1.93 0.32 1578.50 1.00 484 75 42 3 FALSE 0.67
colorectal cancer RAS_13 B2M Inactivating mutation 19 66 TMB quintile 6 0.64 -0.29 1.60 1462.14 1.00 84 8 55 11 FALSE 0.73
colorectal cancer RAS_13 B2M Inactivating mutation 97 111 TMB overall -0.05 -2.51 2.23 1530.87 1.00 568 83 97 14 FALSE 0.02
colorectal cancer RAS_13 TCF7L2 Inactivating mutation 25 13 TMB quintile 3 -0.80 -3.06 0.94 1366.89 1.00 401 25 13 0 FALSE 0.37
colorectal cancer RAS_13 TCF7L2 Inactivating mutation 56 39 TMB quintile 4 -0.48 -1.78 0.61 1497.71 1.00 627 54 37 2 FALSE 0.37
colorectal cancer RAS_13 TCF7L2 Inactivating mutation 70 57 TMB quintile 5 0.36 -0.35 1.03 1477.99 1.00 463 60 47 10 FALSE 0.51
colorectal cancer RAS_13 TCF7L2 Inactivating mutation 16 48 TMB quintile 6 -0.18 -1.29 0.82 1543.04 1.00 77 11 43 5 FALSE 0.13
colorectal cancer RAS_13 TCF7L2 Inactivating mutation 167 157 TMB overall -0.28 -1.63 0.96 1501.94 1.00 1568 150 140 17 FALSE 0.17
colorectal cancer RAS_13 AMER1 Inactivating mutation 62 31 TMB quintile 4 0.03 -1.17 1.01 1394.67 1.00 700 60 29 2 FALSE 0.02
colorectal cancer RAS_13 AMER1 Inactivating mutation 80 47 TMB quintile 5 0.48 -0.27 1.16 1460.38 1.00 508 71 38 9 FALSE 0.72
colorectal cancer RAS_13 AMER1 Inactivating mutation 16 27 TMB quintile 6 0.84 -0.10 1.76 1255.51 1.00 104 10 21 6 FALSE 1.07
colorectal cancer RAS_13 AMER1 Inactivating mutation 158 105 TMB overall 0.45 -0.66 1.47 1451.25 1.00 1312 141 88 17 FALSE 0.40
colorectal cancer KRAS_13 TP53 Inactivating mutation 10 39 TMB quintile 2 -0.56 -1.62 0.21 1600.20 1.00 88 10 39 0 TRUE 0.64
colorectal cancer KRAS_13 TP53 Inactivating mutation 23 146 TMB quintile 3 -0.48 -1.22 0.19 1486.64 1.00 322 19 142 4 TRUE 0.77
colorectal cancer KRAS_13 TP53 Inactivating mutation 59 208 TMB quintile 4 -0.10 -0.62 0.40 1504.18 1.00 544 43 192 16 TRUE 0.16
colorectal cancer KRAS_13 TP53 Inactivating mutation 76 108 TMB quintile 5 -0.18 -0.73 0.35 1406.38 1.00 457 64 96 12 TRUE 0.30
colorectal cancer KRAS_13 TP53 Inactivating mutation 15 31 TMB quintile 6 -0.01 -0.78 0.80 1186.07 1.00 106 10 26 5 TRUE 0.01
colorectal cancer KRAS_13 TP53 Inactivating mutation 183 532 TMB overall -0.26 -0.84 0.34 1180.72 1.00 1517 146 495 37 TRUE 0.43
colorectal cancer KRAS_13 FBXW7 Inactivating mutation 23 11 TMB quintile 3 -0.12 -1.97 1.25 1262.73 1.00 453 23 11 0 TRUE 0.05
colorectal cancer KRAS_13 FBXW7 Inactivating mutation 59 27 TMB quintile 4 0.29 -0.79 1.25 1433.51 1.00 709 56 24 3 TRUE 0.23
colorectal cancer KRAS_13 FBXW7 Inactivating mutation 76 49 TMB quintile 5 0.25 -0.56 0.97 1530.52 1.00 511 69 42 7 TRUE 0.28
colorectal cancer KRAS_13 FBXW7 Inactivating mutation 15 24 TMB quintile 6 0.80 -0.26 1.79 1484.83 1.00 108 10 19 5 TRUE 0.91
colorectal cancer KRAS_13 FBXW7 Inactivating mutation 173 111 TMB overall 0.30 -0.76 1.33 1492.58 1.00 1781 158 96 15 TRUE 0.24
colorectal cancer KRAS_13 PTEN Inactivating mutation 59 17 TMB quintile 4 -0.42 -2.56 1.08 1406.64 1.00 717 58 16 1 TRUE 0.19
colorectal cancer KRAS_13 PTEN Inactivating mutation 77 44 TMB quintile 5 -0.37 -1.41 0.57 1332.22 1.00 519 73 40 4 TRUE 0.32
colorectal cancer KRAS_13 PTEN Inactivating mutation 17 57 TMB quintile 6 0.41 -0.55 1.36 1423.60 1.00 93 9 49 8 TRUE 0.40
colorectal cancer KRAS_13 PTEN Inactivating mutation 153 118 TMB overall -0.12 -1.84 1.50 1398.28 1.00 1329 140 105 13 TRUE 0.05
colorectal cancer KRAS_13 ARID1A Inactivating mutation 59 24 TMB quintile 4 -1.94 -5.74 0.11 1548.53 1.00 709 59 24 0 TRUE 0.73
colorectal cancer KRAS_13 ARID1A Inactivating mutation 76 87 TMB quintile 5 -0.57 -1.46 0.21 1358.37 1.00 484 69 80 7 TRUE 0.73
colorectal cancer KRAS_13 ARID1A Inactivating mutation 18 96 TMB quintile 6 0.15 -0.85 1.08 1499.44 1.00 68 7 85 11 TRUE 0.12
colorectal cancer KRAS_13 ARID1A Inactivating mutation 153 207 TMB overall -0.73 -3.06 1.38 1476.52 1.00 1261 135 189 18 TRUE 0.31
colorectal cancer KRAS_13 APC Inactivating mutation 10 77 TMB quintile 2 0.01 -0.90 0.89 1454.30 1.00 63 5 72 5 TRUE 0.01
colorectal cancer KRAS_13 APC Inactivating mutation 24 422 TMB quintile 3 -0.62 -1.33 0.09 1594.63 1.00 150 12 410 12 TRUE 1.04
colorectal cancer KRAS_13 APC Inactivating mutation 83 936 TMB quintile 4 0.21 -0.33 0.78 1472.99 1.00 147 10 863 73 TRUE 0.35
colorectal cancer KRAS_13 APC Inactivating mutation 126 781 TMB quintile 5 0.83 0.25 1.39 1558.20 1.00 154 10 665 116 TRUE 2.39
colorectal cancer KRAS_13 APC Inactivating mutation 23 151 TMB quintile 6 0.41 -0.32 1.20 1395.31 1.00 63 5 133 18 TRUE 0.54
colorectal cancer KRAS_13 APC Inactivating mutation 266 2367 TMB overall 0.17 -0.50 0.86 1564.31 1.00 577 42 2143 224 TRUE 0.20
colorectal cancer KRAS_13 KMT2D Inactivating mutation 76 46 TMB quintile 5 -0.78 -2.03 0.22 1615.39 1.00 518 73 43 3 FALSE 0.73
colorectal cancer KRAS_13 KMT2D Inactivating mutation 18 111 TMB quintile 6 -0.10 -1.12 0.85 1458.44 1.00 59 7 100 11 FALSE 0.07
colorectal cancer KRAS_13 KMT2D Inactivating mutation 94 157 TMB overall -0.42 -3.05 2.23 1391.82 1.00 577 80 143 14 FALSE 0.13
colorectal cancer KRAS_13 SOX9 Inactivating mutation 23 14 TMB quintile 3 0.14 -1.39 1.41 1442.09 1.00 451 22 13 1 FALSE 0.08
colorectal cancer KRAS_13 SOX9 Inactivating mutation 59 73 TMB quintile 4 0.23 -0.53 0.93 1525.35 1.00 667 52 66 7 FALSE 0.26
colorectal cancer KRAS_13 SOX9 Inactivating mutation 76 88 TMB quintile 5 0.06 -0.62 0.67 1309.96 1.00 480 65 77 11 FALSE 0.07
colorectal cancer KRAS_13 SOX9 Inactivating mutation 16 43 TMB quintile 6 0.17 -0.88 1.15 1305.22 1.00 93 11 38 5 FALSE 0.13
colorectal cancer KRAS_13 SOX9 Inactivating mutation 174 218 TMB overall 0.14 -0.89 1.16 1540.42 1.00 1691 150 194 24 FALSE 0.10
colorectal cancer KRAS_13 RNF43 Inactivating mutation 59 21 TMB quintile 4 -0.97 -3.20 0.66 1499.73 1.00 713 58 20 1 TRUE 0.48
colorectal cancer KRAS_13 RNF43 Inactivating mutation 76 58 TMB quintile 5 -1.52 -2.97 -0.31 1273.01 1.00 503 74 56 2 TRUE 1.56
colorectal cancer KRAS_13 RNF43 Inactivating mutation 17 113 TMB quintile 6 -0.85 -1.85 0.11 1505.99 1.00 51 9 105 8 TRUE 1.08
colorectal cancer KRAS_13 RNF43 Inactivating mutation 152 192 TMB overall -1.09 -3.28 0.90 1434.16 1.00 1267 141 181 11 TRUE 0.54
colorectal cancer KRAS_13 B2M Inactivating mutation 74 45 TMB quintile 5 -0.68 -1.90 0.33 1524.01 1.00 488 71 42 3 FALSE 0.62
colorectal cancer KRAS_13 B2M Inactivating mutation 18 66 TMB quintile 6 0.78 -0.13 1.73 1439.79 1.00 85 7 55 11 FALSE 0.96
colorectal cancer KRAS_13 B2M Inactivating mutation 92 111 TMB overall 0.06 -2.53 2.50 1349.39 1.00 573 78 97 14 FALSE 0.02
colorectal cancer KRAS_13 TCF7L2 Inactivating mutation 23 13 TMB quintile 3 -0.71 -2.98 0.94 1462.56 1.00 403 23 13 0 FALSE 0.31
colorectal cancer KRAS_13 TCF7L2 Inactivating mutation 53 39 TMB quintile 4 -0.42 -1.77 0.67 1442.16 1.00 630 51 37 2 FALSE 0.30
colorectal cancer KRAS_13 TCF7L2 Inactivating mutation 66 57 TMB quintile 5 0.43 -0.34 1.14 1566.13 1.00 467 56 47 10 FALSE 0.60
colorectal cancer KRAS_13 TCF7L2 Inactivating mutation 15 48 TMB quintile 6 -0.07 -1.17 0.96 1441.52 1.00 78 10 43 5 FALSE 0.05
colorectal cancer KRAS_13 TCF7L2 Inactivating mutation 157 157 TMB overall -0.18 -1.46 1.00 1507.65 1.00 1578 140 140 17 FALSE 0.12
colorectal cancer KRAS_13 AMER1 Inactivating mutation 59 31 TMB quintile 4 -0.40 -1.93 0.75 1416.87 1.00 702 58 30 1 FALSE 0.24
colorectal cancer KRAS_13 AMER1 Inactivating mutation 76 47 TMB quintile 5 0.07 -0.74 0.83 1356.20 1.00 509 70 41 6 FALSE 0.07
colorectal cancer KRAS_13 AMER1 Inactivating mutation 15 27 TMB quintile 6 0.83 -0.27 1.87 1511.24 1.00 105 9 21 6 FALSE 0.90
colorectal cancer KRAS_13 AMER1 Inactivating mutation 150 105 TMB overall 0.16 -1.22 1.40 1482.77 1.00 1316 137 92 13 FALSE 0.09
melanoma NRAS_12-61 NF1 Inactivating mutation 14 11 TMB quintile 3 -0.67 -3.07 1.01 1484.49 1.00 87 13 10 1 TRUE 0.29
melanoma NRAS_12-61 NF1 Inactivating mutation 147 117 TMB quintile 5 -1.58 -2.20 -1.02 1345.08 1.00 177 132 102 15 TRUE 6.67
melanoma NRAS_12-61 NF1 Inactivating mutation 11 68 TMB quintile 6 0.72 -0.68 2.44 1379.17 1.00 22 1 58 10 TRUE 0.44
melanoma NRAS_12-61 NF1 Inactivating mutation 172 196 TMB overall -0.51 -2.62 1.69 1536.97 1.00 286 146 170 26 TRUE 0.20
colorectal cancer NRAS_12-61 APC Inactivating mutation 19 422 TMB quintile 3 0.38 -0.57 1.38 1529.20 1.00 157 5 408 14 TRUE 0.35
colorectal cancer NRAS_12-61 APC Inactivating mutation 50 936 TMB quintile 4 1.45 0.42 2.69 1556.99 1.00 156 1 887 49 TRUE 1.89
colorectal cancer NRAS_12-61 APC Inactivating mutation 46 781 TMB quintile 5 0.94 0.09 1.85 1475.24 1.00 160 4 739 42 TRUE 1.39
colorectal cancer NRAS_12-61 APC Inactivating mutation 116 2367 TMB overall 0.49 -0.76 1.54 1536.94 1.00 608 11 2262 105 TRUE 0.40
melanoma RAS_61 NF1 Inactivating mutation 11 11 TMB quintile 3 -2.39 -6.33 0.09 1549.11 1.00 89 11 11 0 TRUE 0.84
melanoma RAS_61 NF1 Inactivating mutation 135 117 TMB quintile 5 -1.88 -2.54 -1.25 1449.36 1.00 185 124 106 11 TRUE 7.77
melanoma RAS_61 NF1 Inactivating mutation 151 196 TMB overall -1.50 -3.95 0.80 1597.14 1.00 296 136 181 15 TRUE 0.70
colorectal cancer RAS_61 APC Inactivating mutation 24 422 TMB quintile 3 -0.40 -1.16 0.36 1258.06 1.00 152 10 408 14 TRUE 0.50
colorectal cancer RAS_61 APC Inactivating mutation 48 936 TMB quintile 4 0.66 -0.13 1.63 1504.09 1.00 154 3 891 45 TRUE 0.84
colorectal cancer RAS_61 APC Inactivating mutation 48 781 TMB quintile 5 0.85 0.02 1.80 1433.52 1.00 161 3 736 45 TRUE 1.23
colorectal cancer RAS_61 APC Inactivating mutation 123 2367 TMB overall -0.08 -1.22 0.99 1273.41 1.00 600 19 2263 104 TRUE 0.06
melanoma NRAS_61 NF1 Inactivating mutation 10 11 TMB quintile 3 -2.21 -5.96 0.48 1457.61 1.00 90 10 11 0 TRUE 0.77
melanoma NRAS_61 NF1 Inactivating mutation 131 117 TMB quintile 5 -1.94 -2.70 -1.29 1517.47 1.00 188 121 107 10 TRUE 7.26
melanoma NRAS_61 NF1 Inactivating mutation 146 196 TMB overall -1.45 -3.89 0.85 1646.83 1.00 300 132 182 14 TRUE 0.67
 

R version 4.2.1 (2022-06-23)
Platform: x86_64-apple-darwin21.5.0 (64-bit)
Running under: macOS Monterey 12.5.1

Matrix products: default
BLAS:   /usr/local/Cellar/openblas/0.3.20/lib/libopenblasp-r0.3.20.dylib
LAPACK: /usr/local/Cellar/r/4.2.1/lib/R/lib/libRlapack.dylib

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] here_1.0.1      gt_0.6.0        forcats_0.5.1   stringr_1.4.0  
 [5] dplyr_1.0.9     purrr_0.3.4     readr_2.1.2     tidyr_1.2.0    
 [9] tibble_3.1.8    ggplot2_3.3.6   tidyverse_1.3.2 magrittr_2.0.3 
[13] workflowr_1.7.0

loaded via a namespace (and not attached):
 [1] httr_1.4.3          sass_0.4.2          bit64_4.0.5        
 [4] vroom_1.5.7         jsonlite_1.8.0      modelr_0.1.8       
 [7] bslib_0.4.0         assertthat_0.2.1    getPass_0.2-2      
[10] highr_0.9           googlesheets4_1.0.1 cellranger_1.1.0   
[13] yaml_2.3.5          pillar_1.8.0        backports_1.4.1    
[16] glue_1.6.2          digest_0.6.29       checkmate_2.1.0    
[19] promises_1.2.0.1    rvest_1.0.2         colorspace_2.0-3   
[22] htmltools_0.5.3     httpuv_1.6.5        pkgconfig_2.0.3    
[25] broom_1.0.0         haven_2.5.0         scales_1.2.0       
[28] processx_3.7.0      whisker_0.4         later_1.3.0        
[31] tzdb_0.3.0          git2r_0.30.1        googledrive_2.0.0  
[34] generics_0.1.3      ellipsis_0.3.2      cachem_1.0.6       
[37] withr_2.5.0         cli_3.3.0           crayon_1.5.1       
[40] readxl_1.4.0        evaluate_0.16       ps_1.7.1           
[43] fs_1.5.2            fansi_1.0.3         xml2_1.3.3         
[46] tools_4.2.1         hms_1.1.1           gargle_1.2.0       
[49] lifecycle_1.0.1     munsell_0.5.0       reprex_2.0.1       
[52] callr_3.7.1         compiler_4.2.1      jquerylib_0.1.4    
[55] rlang_1.0.4         grid_4.2.1          rstudioapi_0.13    
[58] rmarkdown_2.14      gtable_0.3.0        DBI_1.1.3          
[61] R6_2.5.1            lubridate_1.8.0     knitr_1.39         
[64] bit_4.0.4           fastmap_1.1.0       utf8_1.2.2         
[67] rprojroot_2.0.3     stringi_1.7.8       parallel_4.2.1     
[70] Rcpp_1.0.9          vctrs_0.4.1         dbplyr_2.2.1       
[73] tidyselect_1.1.2    xfun_0.32